psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L45	R:R:Y43	3.52	No	No	0	3	6
2	R:R:S44	R:R:V47	3.23	No	No	0	7	5
3	R:R:S44	R:R:T48	4.8	No	No	0	7	4
4	R:R:T50	R:R:V47	4.76	No	No	0	3	5
5	R:R:L49	R:R:T50	4.42	No	No	0	5	3
6	R:R:A55	R:R:L106	4.73	No	No	0	5	8
7	R:R:G56	R:R:M59	3.49	No	Yes	0	6	7
8	R:R:I102	R:R:M59	10.2	No	Yes	0	8	7
9	R:R:M59	R:R:P103	5.03	Yes	No	0	7	9
10	R:R:A98	R:R:T62	3.36	No	Yes	0	9	8
11	R:R:S435	R:R:T62	4.8	No	Yes	0	8	8
12	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
13	R:R:D94	R:R:N66	12.12	No	Yes	0	9	9
14	R:R:I95	R:R:N66	5.66	No	Yes	0	8	9
15	R:R:N66	R:R:P438	6.52	Yes	No	0	9	9
16	R:R:F452	R:R:L68	8.53	No	Yes	0	8	8
17	R:R:A91	R:R:I70	3.25	No	No	0	9	8
18	R:R:A72	R:R:F452	4.16	No	No	0	9	8
19	R:R:N84	R:R:V73	4.43	Yes	No	0	9	8
20	R:R:V73	R:R:V88	4.81	No	No	0	8	7
21	R:R:L79	R:R:S76	9.01	Yes	No	0	9	8
22	R:R:A451	R:R:S76	3.42	No	No	0	8	8
23	R:R:K80	R:R:R77	11.14	No	No	0	7	8
24	R:R:A78	R:R:D447	4.63	No	No	0	7	8
25	R:R:L79	R:R:N84	5.49	Yes	Yes	0	9	9
26	R:R:D447	R:R:L79	9.5	No	Yes	0	8	9
27	R:R:F448	R:R:L79	9.74	No	Yes	0	8	9
28	R:R:A81	R:R:Q83	4.55	No	Yes	2	8	9
29	R:R:A81	R:R:N84	4.69	No	Yes	2	8	9
30	R:R:P82	R:R:Q83	3.16	No	Yes	0	7	9
31	R:R:P162	R:R:P82	3.9	No	No	0	6	7
32	R:R:N84	R:R:Q83	5.28	Yes	Yes	2	9	9
33	R:R:Q83	R:R:R160	11.68	Yes	Yes	2	9	7
34	R:R:L87	R:R:N84	4.12	No	Yes	0	8	9
35	R:R:I165	R:R:L85	5.71	No	No	0	8	8
36	R:R:F86	R:R:I142	3.77	No	No	0	8	9
37	R:R:F86	R:R:I165	5.02	No	No	0	8	8
38	R:R:F86	R:R:I168	6.28	No	No	0	8	7
39	R:R:H138	R:R:S89	11.16	Yes	No	0	8	9
40	R:R:I169	R:R:S89	7.74	No	No	0	8	9
41	R:R:H138	R:R:L90	6.43	Yes	Yes	0	8	9
42	R:R:L139	R:R:L90	5.54	No	Yes	4	8	9
43	R:R:L90	R:R:N437	8.24	Yes	Yes	4	9	9
44	R:R:D94	R:R:S434	4.42	No	No	0	9	9
45	R:R:D94	R:R:N437	5.39	No	Yes	0	9	9
46	R:R:F131	R:R:L96	10.96	Yes	No	0	7	8
47	R:R:V101	R:R:V97	6.41	No	No	1	8	8
48	R:R:F131	R:R:V97	6.55	Yes	No	1	7	8
49	R:R:L100	R:R:T99	4.42	No	No	0	7	6
50	R:R:D128	R:R:V101	5.84	No	No	1	8	8
51	R:R:F131	R:R:V101	3.93	Yes	No	1	7	8
52	R:R:I102	R:R:Y431	3.63	No	Yes	0	8	8
53	R:R:F104	R:R:Y124	6.19	No	No	0	7	7
54	R:R:S105	R:R:Y124	3.82	No	No	0	8	7
55	R:R:E109	R:R:N108	3.94	No	No	0	7	8
56	R:R:F116	R:R:W114	16.04	No	No	0	7	8
57	R:R:C121	R:R:W114	3.92	Yes	No	3	9	8
58	R:R:C203	R:R:W114	9.14	No	No	3	9	8
59	R:R:F116	R:R:Y115	9.28	No	No	0	7	5
60	R:R:E122	R:R:K118	14.85	No	No	0	7	4
61	R:R:A119	R:R:W120	7.78	No	No	0	5	6
62	R:R:I123	R:R:W120	5.87	No	No	0	6	6
63	R:R:C121	R:R:L125	4.76	Yes	No	3	9	7
64	R:R:C121	R:R:C203	7.28	Yes	No	3	9	9
65	R:R:L125	R:R:Y124	3.52	No	No	0	7	7
66	R:R:C203	R:R:L125	4.76	No	No	3	9	7
67	R:R:F131	R:R:L127	6.09	Yes	No	0	7	7
68	R:R:D128	R:R:Y431	5.75	No	Yes	1	8	8
69	L:L:?1	R:R:D128	13.52	Yes	No	1	0	8
70	R:R:S180	R:R:V129	6.46	No	No	0	8	8
71	L:L:?1	R:R:V129	20.55	Yes	No	0	0	8
72	R:R:L130	R:R:S176	6.01	No	No	0	7	8
73	R:R:L130	R:R:S180	7.51	No	No	0	7	8
74	R:R:C132	R:R:W402	5.22	No	Yes	0	7	9
75	R:R:S176	R:R:T133	4.8	No	No	0	8	8
76	R:R:S219	R:R:T133	6.4	No	No	0	8	8
77	R:R:S134	R:R:W173	7.41	No	No	0	8	9
78	R:R:S134	R:R:S176	3.26	No	No	0	8	8
79	R:R:I136	R:R:P223	3.39	No	No	0	9	9
80	R:R:I136	R:R:W402	7.05	No	Yes	0	9	9
81	R:R:V137	R:R:V172	6.41	No	No	0	7	8
82	R:R:H138	R:R:V172	8.3	Yes	No	0	8	8
83	R:R:H138	R:R:W173	7.41	Yes	No	0	8	9
84	R:R:L139	R:R:N437	12.36	No	Yes	4	8	9
85	R:R:L139	R:R:Y441	10.55	No	No	0	8	9
86	R:R:C140	R:R:P223	3.77	No	No	0	7	9
87	R:R:C140	R:R:I226	3.27	No	No	0	7	8
88	R:R:I142	R:R:R146	3.76	No	No	0	9	9
89	R:R:S143	R:R:V230	3.23	No	No	0	9	8
90	R:R:S143	R:R:Y231	3.82	No	Yes	0	9	9
91	R:R:L144	R:R:W148	9.11	No	No	0	7	6
92	R:R:D145	R:R:Y156	5.75	No	No	2	9	9
93	R:R:D145	R:R:R160	7.15	No	Yes	2	9	7
94	R:R:R146	R:R:Y231	6.17	No	Yes	0	9	9
95	R:R:R146	R:R:Y441	6.17	No	No	0	9	9
96	R:R:W148	R:R:Y147	4.82	No	Yes	0	6	8
97	R:R:T151	R:R:Y147	8.74	No	Yes	0	7	8
98	R:R:V230	R:R:Y147	7.57	No	Yes	0	8	8
99	R:R:W148	R:R:Y156	7.72	No	No	0	6	9
100	R:R:R160	R:R:S149	3.95	Yes	No	0	7	9
101	R:R:R160	R:R:Y156	15.43	Yes	No	2	7	9
102	R:R:K159	R:R:R164	8.66	No	No	0	6	8
103	R:R:P162	R:R:T161	5.25	No	No	0	6	8
104	R:R:I168	R:R:R164	5.01	No	No	0	7	8
105	R:R:F181	R:R:P182	8.67	No	No	0	6	8
106	R:R:E204	R:R:I205	6.83	No	No	0	4	7
107	R:R:D207	R:R:E204	11.69	No	No	0	5	4
108	R:R:I205	R:R:Y409	8.46	No	Yes	0	7	8
109	R:R:N206	R:R:Q208	15.85	No	No	0	7	6
110	R:R:N206	R:R:Y211	9.3	No	No	0	7	8
111	R:R:K209	R:R:W210	10.44	No	No	0	5	5
112	R:R:K209	R:R:V414	6.07	No	No	0	5	5
113	R:R:S215	R:R:Y211	5.09	No	No	0	9	8
114	R:R:V212	R:R:Y409	3.79	No	Yes	0	7	8
115	R:R:I213	R:R:V414	4.61	No	No	0	7	5
116	L:L:?1	R:R:S215	8.06	Yes	No	0	0	9
117	R:R:C216	R:R:T410	3.38	No	No	0	7	7
118	R:R:G218	R:R:I217	3.53	No	No	0	6	6
119	R:R:F221	R:R:I217	3.77	No	No	0	7	6
120	L:L:?1	R:R:S219	3.45	Yes	No	0	0	8
121	R:R:F220	R:R:F221	10.72	Yes	No	0	9	7
122	R:R:C224	R:R:F220	4.19	No	Yes	1	7	9
123	R:R:F220	R:R:F398	3.22	Yes	Yes	1	9	9
124	R:R:F220	R:R:F403	4.29	Yes	Yes	0	9	7
125	R:R:F220	R:R:F406	22.51	Yes	Yes	1	9	8
126	R:R:C224	R:R:F398	6.98	No	Yes	1	7	9
127	R:R:F398	R:R:M227	8.71	Yes	No	0	9	9
128	R:R:L391	R:R:Y231	4.69	No	Yes	0	8	9
129	R:R:V394	R:R:Y231	5.05	No	Yes	0	8	9
130	R:R:Q236	R:R:R233	8.18	No	No	0	6	7
131	R:R:I237	R:R:R233	3.76	No	No	0	7	7
132	R:R:K239	R:R:Y235	5.97	No	Yes	0	8	8
133	R:R:F387	R:R:Y235	4.13	No	Yes	5	8	8
134	R:R:T388	R:R:Y235	7.49	No	Yes	5	8	8
135	R:R:A238	R:R:F387	4.16	No	No	0	8	8
136	R:R:E384	R:R:K239	6.75	No	No	0	9	8
137	R:R:E384	R:R:T242	4.23	No	No	0	9	5
138	R:R:N382	R:R:R386	10.85	No	No	0	5	9
139	R:R:R383	R:R:R386	7.46	No	No	0	8	9
140	R:R:F387	R:R:T388	6.49	No	No	5	8	8
141	R:R:F389	R:R:V390	6.55	No	No	0	7	8
142	R:R:F389	R:R:V393	5.24	No	No	0	7	7
143	R:R:F444	R:R:V390	15.73	No	No	0	8	8
144	R:R:I440	R:R:V397	4.61	No	No	0	8	8
145	R:R:C401	R:R:N433	9.45	No	No	0	8	9
146	R:R:F406	R:R:W402	8.02	Yes	Yes	1	8	9
147	R:R:G430	R:R:W402	8.44	No	Yes	0	8	9
148	R:R:N433	R:R:W402	14.69	No	Yes	0	9	9
149	L:L:?1	R:R:W402	7.86	Yes	Yes	1	0	9
150	R:R:F403	R:R:P404	4.33	Yes	No	0	7	9
151	R:R:F403	R:R:F407	6.43	Yes	No	0	7	7
152	R:R:F426	R:R:P404	8.67	No	No	0	7	9
153	R:R:F405	R:R:F406	3.22	Yes	Yes	1	8	8
154	R:R:F405	R:R:Y409	10.32	Yes	Yes	1	8	8
155	R:R:F405	R:R:F423	6.43	Yes	No	1	8	6
156	R:R:F405	R:R:F427	5.36	Yes	No	1	8	7
157	L:L:?1	R:R:F405	13.07	Yes	Yes	1	0	8
158	L:L:?1	R:R:F406	3.73	Yes	Yes	1	0	8
159	R:R:F407	R:R:L411	9.74	No	No	0	7	7
160	R:R:F423	R:R:T408	6.49	No	No	0	6	7
161	R:R:F426	R:R:T408	7.78	No	No	0	7	7
162	R:R:F423	R:R:Y409	4.13	No	Yes	1	6	8
163	L:L:?1	R:R:Y409	6.29	Yes	Yes	1	0	8
164	R:R:S417	R:R:T412	4.8	No	No	0	1	5
165	R:R:P419	R:R:T412	10.49	No	No	0	7	5
166	R:R:G415	R:R:V414	3.68	No	No	0	3	5
167	R:R:R420	R:R:V418	6.54	No	No	0	4	6
168	R:R:F425	R:R:L422	3.65	No	No	0	6	7
169	R:R:F427	R:R:Y431	10.32	No	Yes	1	7	8
170	L:L:?1	R:R:F427	19.6	Yes	No	1	0	7
171	R:R:W428	R:R:Y431	4.82	No	Yes	0	7	8
172	L:L:?1	R:R:Y431	8.09	Yes	Yes	1	0	8
173	R:R:L436	R:R:S435	4.5	No	No	0	7	8
174	R:R:N437	R:R:P438	3.26	Yes	No	0	9	9
175	R:R:I440	R:R:Y441	3.63	No	No	0	8	9
176	R:R:F448	R:R:T442	14.27	No	No	0	8	9
177	R:R:F452	R:R:T442	9.08	No	No	0	8	9
178	R:R:F444	R:R:I443	8.79	No	No	0	8	7
179	R:R:F448	R:R:N445	7.25	No	No	0	8	9
180	R:R:H446	R:R:R450	4.51	No	No	0	6	6
181	R:R:I455	R:R:K454	4.36	No	No	0	8	7
182	R:R:C457	R:R:L456	3.17	No	No	0	6	8
183	R:R:I102	R:R:S105	3.1	No	No	0	8	8
184	R:R:I179	R:R:S180	3.1	No	No	0	8	8
185	R:R:I175	R:R:V178	3.07	No	No	0	7	6
186	R:R:I443	R:R:V439	3.07	No	No	0	7	7
187	R:R:I71	R:R:T75	3.04	No	No	0	7	7
188	R:R:M111	R:R:V110	3.04	Yes	No	0	7	7
189	R:R:I150	R:R:T151	3.04	No	No	0	8	7
190	R:R:L90	R:R:S135	3	Yes	No	0	9	9
191	R:R:G379	R:R:R378	3	No	No	0	4	6
192	R:R:L51	R:R:V47	2.98	No	No	0	6	5
193	R:R:L106	R:R:V52	2.98	No	No	0	8	6
194	R:R:L58	R:R:T62	2.95	No	Yes	0	7	8
195	R:R:I150	R:R:I234	2.94	No	No	0	8	9
196	R:R:I175	R:R:I179	2.94	No	No	0	7	8
197	R:R:I228	R:R:I395	2.94	No	No	0	6	7
198	R:R:N66	R:R:T62	2.92	Yes	Yes	0	9	8
199	R:R:I395	R:R:M227	2.92	No	No	0	7	9
200	R:R:I455	R:R:L68	2.85	No	Yes	0	8	8
201	R:R:Q152	R:R:T151	2.83	No	No	0	7	7
202	R:R:K166	R:R:L85	2.82	No	No	0	6	8
203	R:R:C216	R:R:F406	2.79	No	Yes	0	7	8
204	R:R:C432	R:R:F429	2.79	No	No	0	7	8
205	R:R:L100	R:R:L127	2.77	No	No	0	7	7
206	R:R:L225	R:R:L229	2.77	No	No	0	5	5
207	R:R:N382	R:R:Q381	2.64	No	No	0	5	6
208	R:R:F74	R:R:V73	2.62	No	No	0	6	8
209	R:R:F398	R:R:V399	2.62	Yes	No	0	9	7
210	R:R:F403	R:R:V399	2.62	Yes	No	0	7	7
211	R:R:A93	R:R:W173	2.59	No	No	0	8	9
212	R:R:R163	R:R:T161	2.59	No	No	0	5	8
213	R:R:H446	R:R:N445	2.55	No	No	0	6	9
214	R:R:F64	R:R:L68	2.44	No	Yes	0	5	8
215	R:R:M111	R:R:Y43	2.39	Yes	No	0	7	6
216	R:R:L391	R:R:Y235	2.34	No	Yes	0	8	8
217	R:R:E109	R:R:W428	2.18	No	No	0	7	7
218	R:R:R202	R:R:Y113	2.06	No	No	0	5	5
219	R:R:R233	R:R:Y147	2.06	No	Yes	0	7	8
220	R:R:A55	R:R:G56	1.95	No	No	0	5	6
221	R:R:A222	R:R:P223	1.87	No	No	0	6	9
222	R:R:P438	R:R:V69	1.77	No	No	0	9	9
223	R:R:P419	R:R:V418	1.77	No	No	0	7	6
224	R:R:G396	R:R:I395	1.76	No	No	0	7	7
225	R:R:G112	R:R:M111	1.75	No	Yes	0	6	7
226	R:R:C53	R:R:V52	1.71	No	No	0	5	6
227	R:R:G65	R:R:L68	1.71	No	Yes	0	9	8
228	R:R:C401	R:R:V400	1.71	No	No	0	8	5
229	R:R:A98	R:R:V63	1.7	No	No	0	9	7
230	R:R:A141	R:R:V172	1.7	No	No	0	8	8
231	R:R:A413	R:R:V212	1.7	No	No	0	7	7
232	R:R:G379	R:R:N382	1.7	No	No	0	4	5
233	R:R:S89	R:R:S92	1.63	No	No	0	9	7
234	R:R:V393	R:R:V397	1.6	No	No	0	7	8
235	R:R:T48	R:R:V52	1.59	No	No	0	4	6
236	R:R:T48	R:R:V110	1.59	No	No	0	4	7
237	R:R:C432	R:R:L58	1.59	No	No	0	7	7
238	R:R:A177	R:R:L130	1.58	No	No	0	7	7
239	R:R:P183	R:R:Q208	1.58	No	No	0	8	6
240	R:R:I71	R:R:V67	1.54	No	No	0	7	6
241	R:R:I228	R:R:V232	1.54	No	No	0	6	4
242	R:R:I455	R:R:T75	1.52	No	No	0	8	7
243	R:R:C121	R:R:E122	1.52	Yes	No	0	9	7
244	R:R:I170	R:R:T171	1.52	No	No	0	5	5
245	R:R:I213	R:R:T410	1.52	No	No	0	7	7
246	R:R:F116	R:R:G117	1.51	No	No	0	7	7
247	R:R:L61	R:R:S435	1.5	No	No	0	5	8
248	R:R:L411	R:R:T412	1.47	No	No	0	7	5
249	R:R:L60	R:R:M59	1.41	No	Yes	0	6	7
250	R:R:K159	R:R:L158	1.41	No	No	0	6	6
251	R:R:E122	R:R:I123	1.37	No	No	0	7	6
252	R:R:L158	R:R:N157	1.37	No	No	0	6	7
253	R:R:E155	R:R:Q152	1.27	No	No	0	6	7
254	R:R:I237	R:R:R241	1.25	No	No	0	7	8
255	R:R:I443	R:R:R449	1.25	No	No	0	7	9
256	R:R:M111	R:R:Y113	1.2	Yes	No	0	7	5
257	R:R:K424	R:R:W428	1.16	No	No	0	7	7
258	R:R:R240	R:R:R241	1.07	No	No	0	7	8
259	R:R:R378	R:R:R380	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M59	5.0325	4	0	7
2	R:R:T62	3.5075	4	0	8
3	R:R:N66	6.382	5	0	9
4	R:R:L68	3.8825	4	0	8
5	R:R:L79	8.435	4	0	9
6	R:R:Q83	6.1675	4	2	9
7	R:R:N84	4.802	5	2	9
8	R:R:L90	5.8025	4	4	9
9	R:R:M111	2.095	4	0	7
10	R:R:C121	4.37	4	3	9
11	R:R:F131	6.8825	4	1	7
12	R:R:H138	8.325	4	0	8
13	R:R:Y147	5.7975	4	0	8
14	R:R:R160	9.5525	4	2	7
15	R:R:F220	8.986	5	1	9
16	R:R:Y231	4.9325	4	0	9
17	R:R:Y235	4.9825	4	5	8
18	R:R:F398	5.3825	4	1	9
19	R:R:W402	8.54667	6	1	9
20	R:R:F403	4.4175	4	0	7
21	R:R:F405	7.68	5	1	8
22	R:R:F406	8.054	5	1	8
23	R:R:Y409	6.598	5	1	8
24	R:R:Y431	6.522	5	1	8
25	R:R:N437	7.3125	4	4	9
26	L:L:?1	10.422	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T48	R:R:V110	11.1254	1.59	No	No	0	4	7
2	R:R:A55	R:R:L106	24.5327	4.73	No	No	0	5	8
3	R:R:L106	R:R:V52	23.0888	2.98	No	No	0	8	6
4	R:R:T48	R:R:V52	20.1818	1.59	No	No	0	4	6
5	R:R:A55	R:R:G56	25.9636	1.95	No	No	0	5	6
6	R:R:G56	R:R:M59	27.3753	3.49	No	Yes	0	6	7
7	R:R:I102	R:R:M59	31.5328	10.2	No	Yes	0	8	7
8	R:R:N66	R:R:T62	25.983	2.92	Yes	Yes	0	9	8
9	R:R:D94	R:R:N66	18.6219	12.12	No	Yes	0	9	9
10	R:R:D94	R:R:N437	21.2904	5.39	No	Yes	0	9	9
11	R:R:L90	R:R:N437	27.3688	8.24	Yes	Yes	4	9	9
12	R:R:H138	R:R:L90	99.3554	6.43	Yes	Yes	0	8	9
13	R:R:H138	R:R:W173	99.942	7.41	Yes	No	0	8	9
14	R:R:S134	R:R:W173	99.9936	7.41	No	No	0	8	9
15	R:R:S134	R:R:S176	100	3.26	No	No	0	8	8
16	R:R:S176	R:R:T133	94.3599	4.8	No	No	0	8	8
17	R:R:S219	R:R:T133	94.2632	6.4	No	No	0	8	8
18	L:L:?1	R:R:S219	94.2052	3.45	Yes	No	0	0	8
19	L:L:?1	R:R:Y431	57.374	8.09	Yes	Yes	1	0	8
20	R:R:I102	R:R:Y431	55.9237	3.63	No	Yes	0	8	8
21	R:R:N66	R:R:P438	18.6219	6.52	Yes	No	0	9	9
22	R:R:N437	R:R:P438	21.2904	3.26	Yes	No	0	9	9
23	R:R:F452	R:R:T442	15.3216	9.08	No	No	0	8	9
24	R:R:F448	R:R:T442	16.8106	14.27	No	No	0	8	9
25	R:R:F448	R:R:L79	22.5861	9.74	No	Yes	0	8	9
26	R:R:L79	R:R:N84	29.5153	5.49	Yes	Yes	0	9	9
27	R:R:N84	R:R:Q83	35.9611	5.28	Yes	Yes	2	9	9
28	R:R:Q83	R:R:R160	43.6251	11.68	Yes	Yes	2	9	7
29	R:R:R160	R:R:Y156	45.6878	15.43	Yes	No	2	7	9
30	R:R:W148	R:R:Y156	48.2596	7.72	No	No	0	6	9
31	R:R:W148	R:R:Y147	50.5543	4.82	No	Yes	0	6	8
32	R:R:V230	R:R:Y147	62.2792	7.57	No	Yes	0	8	8
33	R:R:S143	R:R:V230	63.2654	3.23	No	No	0	9	8
34	R:R:S143	R:R:Y231	64.2388	3.82	No	Yes	0	9	9
35	R:R:R146	R:R:Y231	72.7859	6.17	No	Yes	0	9	9
36	R:R:R146	R:R:Y441	81.1654	6.17	No	No	0	9	9
37	R:R:L139	R:R:Y441	87.4694	10.55	No	No	0	8	9
38	R:R:L139	R:R:L90	71.6965	5.54	No	Yes	4	8	9
39	R:R:F452	R:R:L68	12.3308	8.53	No	Yes	0	8	8
40	R:R:F86	R:R:I142	13.852	3.77	No	No	0	8	9
41	R:R:I142	R:R:R146	15.2894	3.76	No	No	0	9	9
42	R:R:D128	R:R:V101	11.003	5.84	No	No	1	8	8
43	R:R:S105	R:R:Y124	27.1239	3.82	No	No	0	8	7
44	R:R:I102	R:R:S105	28.5355	3.1	No	No	0	8	8
45	R:R:C121	R:R:L125	15.399	4.76	Yes	No	3	9	7
46	R:R:L125	R:R:Y124	24.4102	3.52	No	No	0	7	7
47	L:L:?1	R:R:W402	14.8124	7.86	Yes	Yes	1	0	9
48	L:L:?1	R:R:Y409	12.6595	6.29	Yes	Yes	1	0	8
49	R:R:C216	R:R:F406	11.1834	2.79	No	Yes	0	7	8
50	L:L:?1	R:R:F406	39.0164	3.73	Yes	Yes	1	0	8
51	R:R:F220	R:R:F406	32.7188	22.51	Yes	Yes	1	9	8
52	R:R:F220	R:R:F398	11.0159	3.22	Yes	Yes	1	9	9
53	R:R:F220	R:R:F403	15.6633	4.29	Yes	Yes	0	9	7
54	R:R:L391	R:R:Y231	11.9956	4.69	No	Yes	0	8	9
55	R:R:L391	R:R:Y235	10.584	2.34	No	Yes	0	8	8
56	R:R:V393	R:R:V397	10.9578	1.6	No	No	0	7	8
57	R:R:I440	R:R:V397	12.4726	4.61	No	No	0	8	8
58	R:R:I440	R:R:Y441	13.9745	3.63	No	No	0	8	9
59	R:R:F403	R:R:F407	11.409	6.43	Yes	No	0	7	7
60	R:R:L139	R:R:N437	16.3788	12.36	No	Yes	4	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D128	R:R:V101	5.84	1	No	No	8	8	1	2
R:R:I102	R:R:Y431	3.63	0	No	Yes	8	8	2	1
R:R:D128	R:R:Y431	5.75	1	No	Yes	8	8	1	1
L:L:?1	R:R:D128	13.52	1	Yes	No	0	8	0	1
R:R:S180	R:R:V129	6.46	0	No	No	8	8	2	1
L:L:?1	R:R:V129	20.55	1	Yes	No	0	8	0	1
R:R:C132	R:R:W402	5.22	0	No	Yes	7	9	2	1
R:R:S219	R:R:T133	6.4	0	No	No	8	8	1	2
R:R:I136	R:R:W402	7.05	0	No	Yes	9	9	2	1
R:R:I205	R:R:Y409	8.46	0	No	Yes	7	8	2	1
R:R:S215	R:R:Y211	5.09	0	No	No	9	8	1	2
R:R:V212	R:R:Y409	3.79	0	No	Yes	7	8	2	1
L:L:?1	R:R:S215	8.06	1	Yes	No	0	9	0	1
L:L:?1	R:R:S219	3.45	1	Yes	No	0	8	0	1
R:R:F220	R:R:F406	22.51	1	Yes	Yes	9	8	2	1
R:R:F406	R:R:W402	8.02	1	Yes	Yes	8	9	1	1
R:R:G430	R:R:W402	8.44	0	No	Yes	8	9	2	1
R:R:N433	R:R:W402	14.69	0	No	Yes	9	9	2	1
L:L:?1	R:R:W402	7.86	1	Yes	Yes	0	9	0	1
R:R:F405	R:R:F406	3.22	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:Y409	10.32	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:F423	6.43	1	Yes	No	8	6	1	2
R:R:F405	R:R:F427	5.36	1	Yes	No	8	7	1	1
L:L:?1	R:R:F405	13.07	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F406	3.73	1	Yes	Yes	0	8	0	1
R:R:F423	R:R:Y409	4.13	1	No	Yes	6	8	2	1
L:L:?1	R:R:Y409	6.29	1	Yes	Yes	0	8	0	1
R:R:F427	R:R:Y431	10.32	1	No	Yes	7	8	1	1
L:L:?1	R:R:F427	19.6	1	Yes	No	0	7	0	1
R:R:W428	R:R:Y431	4.82	0	No	Yes	7	8	2	1
L:L:?1	R:R:Y431	8.09	1	Yes	Yes	0	8	0	1
R:R:C216	R:R:F406	2.79	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EJ8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.16
Number of Linked Nodes	248
Number of Links	259
Number of Hubs	26
Number of Links mediated by Hubs	102
Number of Communities	5
Number of Nodes involved in Communities	31
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	30719
Length Of Smallest Path	3
Average Path Length	15.8182
Length of Longest Path	41
Minimum Path Strength	1.16
Average Path Strength	6.17836
Maximum Path Strength	20.075
Minimum Path Correlation	0.7
Average Path Correlation	0.923874
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	47.9186
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.3297
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J59
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J59
Name	Brimonidine
Synonyms	Brimonidine
Identifier
Formula	C11 H10 Br N5
Molecular Weight	292.135
SMILES
PubChem	2435
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	0
Total Bonds	29
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>7EJ8_nogp_Chain_R Y S L Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P P R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS-79948	-	-	2.7	2019-12-04	doi.org/10.1038/nature06325
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	doi.org/10.1038/nature06325
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-		3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	doi.org/10.1126/science.abn7065
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9IQR	A	Amine	Adrenegic	α_2a	Homo sapiens	-	Muscarinic toxin 3	-	3.4	2025-07-23	To be published
	9PLN	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-	-	2.8	2025-08-20	To be published
	9PQD	A	Amine	Adrenegic	α_2a	Homo sapiens	(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole	-	-	3.29	2025-08-20	To be published
	9PLO	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-	Go/β1/γ2	2.74	2025-08-20	To be published
	9PLO (No Gprot)	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-		2.74	2025-08-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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