psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D128	4.89	Yes	No	1	0	8
2	L:L:?1	R:R:V129	21.48	Yes	No	0	0	8
3	L:L:?1	R:R:C132	10.3	Yes	No	1	0	7
4	L:L:?1	R:R:W402	4.93	Yes	Yes	1	0	9
5	L:L:?1	R:R:F405	11.42	Yes	Yes	1	0	8
6	L:L:?1	R:R:F406	6.15	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y409	5.92	Yes	Yes	1	0	8
8	L:L:?1	R:R:F427	15.81	Yes	No	1	0	7
9	L:L:?1	R:R:Y431	10.14	Yes	Yes	1	0	8
10	R:R:T48	R:R:Y43	7.49	Yes	No	0	4	6
11	R:R:S44	R:R:V47	8.08	No	No	0	7	5
12	R:R:S44	R:R:T48	4.8	No	Yes	0	7	4
13	R:R:L51	R:R:V47	4.47	No	No	0	6	5
14	R:R:T48	R:R:V110	4.76	Yes	No	0	4	7
15	R:R:C53	R:R:L54	4.76	No	No	0	5	5
16	R:R:A55	R:R:L106	4.73	No	No	0	5	8
17	R:R:L61	R:R:S435	4.5	No	No	0	5	8
18	R:R:A98	R:R:T62	5.03	No	No	0	9	8
19	R:R:S435	R:R:T62	7.99	No	No	0	8	8
20	R:R:F64	R:R:G65	4.52	No	No	0	5	9
21	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
22	R:R:D94	R:R:N66	12.12	No	Yes	0	9	9
23	R:R:I95	R:R:N66	4.25	No	Yes	0	8	9
24	R:R:N66	R:R:P438	13.03	Yes	No	0	9	9
25	R:R:F452	R:R:L68	12.18	Yes	No	0	8	8
26	R:R:I455	R:R:L68	4.28	No	No	0	8	8
27	R:R:F452	R:R:V69	3.93	Yes	No	0	8	9
28	R:R:I71	R:R:T75	4.56	No	No	0	7	7
29	R:R:N84	R:R:V73	4.43	Yes	No	0	9	8
30	R:R:V73	R:R:V88	4.81	No	No	0	8	7
31	R:R:L79	R:R:S76	12.01	Yes	No	0	9	8
32	R:R:L79	R:R:N84	4.12	Yes	Yes	0	9	9
33	R:R:D447	R:R:L79	4.07	Yes	Yes	0	8	9
34	R:R:F448	R:R:L79	7.31	Yes	Yes	0	8	9
35	R:R:A81	R:R:Q83	6.06	No	Yes	0	8	9
36	R:R:P82	R:R:Q83	6.32	No	Yes	0	7	9
37	R:R:P162	R:R:P82	5.84	No	No	0	6	7
38	R:R:I165	R:R:P82	5.08	No	No	0	8	7
39	R:R:N84	R:R:Q83	5.28	Yes	Yes	0	9	9
40	R:R:Q83	R:R:R160	9.35	Yes	No	0	9	7
41	R:R:L87	R:R:N84	4.12	No	Yes	0	8	9
42	R:R:I165	R:R:L85	5.71	No	No	0	8	8
43	R:R:K166	R:R:L85	5.64	No	No	0	6	8
44	R:R:F86	R:R:I142	5.02	No	No	0	8	9
45	R:R:F86	R:R:I165	8.79	No	No	0	8	8
46	R:R:F86	R:R:I168	8.79	No	No	0	8	7
47	R:R:H138	R:R:S89	11.16	Yes	No	0	8	9
48	R:R:I169	R:R:S89	6.19	No	No	0	8	9
49	R:R:H138	R:R:L90	5.14	Yes	No	0	8	9
50	R:R:L139	R:R:L90	5.54	No	No	2	8	9
51	R:R:L90	R:R:N437	12.36	No	No	2	9	9
52	R:R:A93	R:R:W173	3.89	No	No	0	8	9
53	R:R:D94	R:R:V97	4.38	No	No	0	9	8
54	R:R:D94	R:R:S434	8.83	No	No	0	9	9
55	R:R:F131	R:R:L96	10.96	Yes	No	0	7	8
56	R:R:V101	R:R:V97	8.02	Yes	No	0	8	8
57	R:R:F131	R:R:V97	5.24	Yes	No	0	7	8
58	R:R:L100	R:R:T99	4.42	Yes	No	0	7	6
59	R:R:L100	R:R:V101	4.47	Yes	Yes	1	7	8
60	R:R:L100	R:R:L127	6.92	Yes	No	1	7	7
61	R:R:F131	R:R:L100	4.87	Yes	Yes	1	7	7
62	R:R:D128	R:R:V101	8.76	No	Yes	1	8	8
63	R:R:V101	R:R:Y431	6.31	Yes	Yes	1	8	8
64	R:R:I102	R:R:P103	5.08	No	No	0	8	9
65	R:R:F104	R:R:W114	8.02	No	Yes	3	7	8
66	R:R:F104	R:R:F116	11.79	No	Yes	3	7	7
67	R:R:F104	R:R:Y124	9.28	No	No	3	7	7
68	R:R:S105	R:R:Y124	3.82	No	No	0	8	7
69	R:R:S105	R:R:Y431	6.36	No	Yes	0	8	8
70	R:R:A107	R:R:M111	4.83	No	Yes	0	7	7
71	R:R:E109	R:R:W428	9.81	No	No	0	7	7
72	R:R:F116	R:R:M111	3.73	Yes	Yes	0	7	7
73	R:R:Y113	R:R:Y115	16.88	No	No	0	5	5
74	R:R:R202	R:R:Y113	4.12	No	No	0	5	5
75	R:R:F116	R:R:W114	5.01	Yes	Yes	3	7	8
76	R:R:W114	R:R:Y124	7.72	Yes	No	3	8	7
77	R:R:C203	R:R:W114	6.53	No	Yes	3	9	8
78	R:R:G117	R:R:W120	4.22	No	No	0	7	6
79	R:R:C121	R:R:K118	6.47	No	No	0	9	4
80	R:R:I123	R:R:W120	5.87	No	No	0	6	6
81	R:R:C121	R:R:L125	4.76	No	No	3	9	7
82	R:R:C121	R:R:C203	7.28	No	No	3	9	9
83	R:R:C203	R:R:L125	4.76	No	No	3	9	7
84	R:R:F131	R:R:L127	8.53	Yes	No	1	7	7
85	R:R:D128	R:R:Y431	9.2	No	Yes	1	8	8
86	R:R:S180	R:R:V129	4.85	No	No	0	8	8
87	R:R:L130	R:R:S176	4.5	No	No	0	7	8
88	R:R:L130	R:R:S180	7.51	No	No	0	7	8
89	R:R:C132	R:R:W402	3.92	No	Yes	1	7	9
90	R:R:I179	R:R:T133	4.56	No	No	0	8	8
91	R:R:S219	R:R:T133	6.4	No	No	0	8	8
92	R:R:S134	R:R:W173	7.41	No	No	0	8	9
93	R:R:F398	R:R:I136	3.77	Yes	Yes	1	9	9
94	R:R:I136	R:R:W402	8.22	Yes	Yes	1	9	9
95	R:R:V137	R:R:V172	6.41	No	No	0	7	8
96	R:R:H138	R:R:V172	11.07	Yes	No	0	8	8
97	R:R:H138	R:R:W173	7.41	Yes	No	0	8	9
98	R:R:L139	R:R:N437	6.87	No	No	2	8	9
99	R:R:L139	R:R:Y441	10.55	No	Yes	2	8	9
100	R:R:C140	R:R:P223	3.77	No	No	0	7	9
101	R:R:C140	R:R:I226	4.91	No	No	0	7	8
102	R:R:I142	R:R:R146	6.26	No	No	2	9	9
103	R:R:I142	R:R:Y441	4.84	No	Yes	2	9	9
104	R:R:M227	R:R:S143	7.67	No	No	0	9	9
105	R:R:S143	R:R:V230	6.46	No	No	2	9	8
106	R:R:S143	R:R:Y231	3.82	No	Yes	2	9	9
107	R:R:L144	R:R:W148	5.69	No	Yes	0	7	6
108	R:R:D145	R:R:Y156	11.49	No	Yes	0	9	9
109	R:R:R146	R:R:Y231	8.23	No	Yes	2	9	9
110	R:R:R146	R:R:Y441	11.32	No	Yes	2	9	9
111	R:R:W148	R:R:Y147	4.82	Yes	Yes	0	6	8
112	R:R:T151	R:R:Y147	8.74	No	Yes	0	7	8
113	R:R:V230	R:R:Y147	6.31	No	Yes	0	8	8
114	R:R:Q152	R:R:W148	5.48	No	Yes	0	7	6
115	R:R:W148	R:R:Y156	11.58	Yes	Yes	0	6	9
116	R:R:R160	R:R:S149	7.91	No	No	0	7	9
117	R:R:E155	R:R:Q152	3.82	No	No	0	6	7
118	R:R:E155	R:R:I154	5.47	No	No	0	6	7
119	R:R:R160	R:R:Y156	8.23	No	Yes	0	7	9
120	R:R:R164	R:R:Y156	5.14	No	Yes	0	8	9
121	R:R:K159	R:R:R164	9.9	No	No	0	6	8
122	R:R:I168	R:R:R164	5.01	No	No	0	7	8
123	R:R:I179	R:R:S215	4.64	No	No	0	8	9
124	R:R:F181	R:R:P182	7.22	No	No	0	6	8
125	R:R:N206	R:R:Q208	15.85	No	No	6	7	6
126	R:R:N206	R:R:Y211	10.47	No	Yes	6	7	8
127	R:R:Q208	R:R:Y211	4.51	No	Yes	6	6	8
128	R:R:W210	R:R:Y211	5.79	No	Yes	0	5	8
129	R:R:S215	R:R:Y211	5.09	No	Yes	0	9	8
130	R:R:V212	R:R:Y409	11.36	No	Yes	0	7	8
131	R:R:C216	R:R:F221	4.19	No	No	0	7	7
132	R:R:C216	R:R:F406	5.59	No	Yes	0	7	8
133	R:R:C216	R:R:T410	5.07	No	No	0	7	7
134	R:R:F221	R:R:I217	8.79	No	No	0	7	6
135	R:R:F220	R:R:F221	6.43	Yes	No	0	9	7
136	R:R:C224	R:R:F220	8.38	No	Yes	1	7	9
137	R:R:F220	R:R:F398	6.43	Yes	Yes	1	9	9
138	R:R:F220	R:R:W402	4.01	Yes	Yes	1	9	9
139	R:R:F220	R:R:F403	7.5	Yes	No	0	9	7
140	R:R:F220	R:R:F406	21.43	Yes	Yes	1	9	8
141	R:R:A222	R:R:P223	3.74	No	No	0	6	9
142	R:R:C224	R:R:F398	6.98	No	Yes	1	7	9
143	R:R:L225	R:R:L229	5.54	No	No	0	5	5
144	R:R:V230	R:R:Y231	5.05	No	Yes	2	8	9
145	R:R:L391	R:R:Y231	5.86	No	Yes	0	8	9
146	R:R:V394	R:R:Y231	5.05	No	Yes	0	8	9
147	R:R:I395	R:R:Y231	8.46	No	Yes	0	7	9
148	R:R:Y231	R:R:Y441	3.97	Yes	Yes	2	9	9
149	R:R:Q236	R:R:V232	4.3	No	No	0	6	4
150	R:R:Q236	R:R:R233	7.01	No	No	0	6	7
151	R:R:K239	R:R:Y235	16.72	No	Yes	4	8	8
152	R:R:E384	R:R:Y235	4.49	Yes	Yes	4	9	8
153	R:R:F387	R:R:Y235	6.19	No	Yes	4	8	8
154	R:R:T388	R:R:Y235	11.24	No	Yes	4	8	8
155	R:R:A238	R:R:F387	8.32	No	No	0	8	8
156	R:R:E384	R:R:K239	5.4	Yes	No	4	9	8
157	R:R:E384	R:R:T242	7.06	Yes	No	0	9	5
158	R:R:R376	R:R:W377	14.99	No	No	0	7	5
159	R:R:K385	R:R:Q381	5.42	No	No	0	7	6
160	R:R:N382	R:R:R386	14.46	No	No	0	5	9
161	R:R:R383	R:R:R386	4.26	No	No	0	8	9
162	R:R:E384	R:R:F387	15.16	Yes	No	4	9	8
163	R:R:E384	R:R:T388	5.64	Yes	No	4	9	8
164	R:R:F444	R:R:V390	22.28	Yes	No	0	8	8
165	R:R:F444	R:R:V393	3.93	Yes	No	0	8	7
166	R:R:I440	R:R:V394	4.61	No	No	0	8	8
167	R:R:I440	R:R:V397	9.22	No	No	0	8	8
168	R:R:F398	R:R:W402	7.02	Yes	Yes	1	9	9
169	R:R:C401	R:R:N433	9.45	No	No	0	8	9
170	R:R:F406	R:R:W402	9.02	Yes	Yes	1	8	9
171	R:R:G430	R:R:W402	5.63	No	Yes	0	8	9
172	R:R:N433	R:R:W402	12.43	No	Yes	0	9	9
173	R:R:F403	R:R:F407	5.36	No	No	0	7	7
174	R:R:F426	R:R:P404	10.11	Yes	No	0	7	9
175	R:R:F405	R:R:F406	10.72	Yes	Yes	1	8	8
176	R:R:F405	R:R:Y409	7.22	Yes	Yes	1	8	8
177	R:R:F405	R:R:F423	9.65	Yes	Yes	1	8	6
178	R:R:F407	R:R:L411	15.83	No	No	0	7	7
179	R:R:P419	R:R:T408	8.74	Yes	No	1	7	7
180	R:R:F423	R:R:T408	6.49	Yes	No	1	6	7
181	R:R:F426	R:R:T408	12.97	Yes	No	0	7	7
182	R:R:F423	R:R:Y409	5.16	Yes	Yes	1	6	8
183	R:R:C416	R:R:L411	6.35	No	No	0	8	7
184	R:R:S417	R:R:T412	9.59	No	No	0	1	5
185	R:R:F423	R:R:P419	5.78	Yes	Yes	1	6	7
186	R:R:K424	R:R:T421	9.01	No	No	0	7	5
187	R:R:F425	R:R:T421	3.89	No	No	0	6	5
188	R:R:F426	R:R:L422	13.4	Yes	No	0	7	7
189	R:R:F427	R:R:Y431	11.35	No	Yes	1	7	8
190	R:R:W428	R:R:Y431	6.75	No	Yes	0	7	8
191	R:R:N437	R:R:P438	4.89	No	No	0	9	9
192	R:R:I443	R:R:V439	7.68	No	No	0	7	7
193	R:R:F448	R:R:T442	12.97	Yes	No	5	8	9
194	R:R:F452	R:R:T442	11.67	Yes	No	5	8	9
195	R:R:D447	R:R:N445	5.39	Yes	No	0	8	9
196	R:R:F448	R:R:N445	7.25	Yes	No	0	8	9
197	R:R:H446	R:R:R450	9.03	No	No	0	6	6
198	R:R:F448	R:R:F452	4.29	Yes	Yes	5	8	8
199	R:R:K80	R:R:R77	3.71	No	No	0	7	8
200	R:R:F64	R:R:L68	3.65	No	No	0	5	8
201	R:R:F425	R:R:L422	3.65	No	No	0	6	7
202	R:R:I102	R:R:Y431	3.63	No	Yes	0	8	8
203	R:R:G218	R:R:I217	3.53	No	No	0	6	6
204	R:R:P419	R:R:V418	3.53	Yes	No	0	7	6
205	R:R:P162	R:R:T161	3.5	No	No	0	6	8
206	R:R:P419	R:R:T412	3.5	Yes	No	0	7	5
207	R:R:I136	R:R:P223	3.39	Yes	No	0	9	9
208	R:R:A413	R:R:V212	3.39	No	No	0	7	7
209	R:R:M59	R:R:P103	3.35	No	No	0	7	9
210	R:R:N206	R:R:P183	3.26	No	No	0	7	8
211	L:L:?1	R:R:S215	3.25	Yes	No	0	0	9
212	L:L:?1	R:R:S219	3.25	Yes	No	0	0	8
213	R:R:A91	R:R:I70	3.25	No	No	0	9	8
214	R:R:A98	R:R:I102	3.25	No	No	0	9	8
215	R:R:F389	R:R:F444	3.22	No	Yes	0	7	8
216	R:R:C457	R:R:L456	3.17	No	No	0	6	8
217	R:R:I136	R:R:S135	3.1	Yes	No	0	9	9
218	R:R:A78	R:R:D447	3.09	No	Yes	0	7	8
219	R:R:R233	R:R:Y147	3.09	No	Yes	0	7	8
220	R:R:I168	R:R:T171	3.04	No	No	0	7	5
221	R:R:K209	R:R:V414	3.04	No	No	0	5	5
222	R:R:I213	R:R:T410	3.04	No	No	0	7	7
223	R:R:I443	R:R:T442	3.04	No	No	0	7	9
224	R:R:L58	R:R:S435	3	No	No	0	7	8
225	R:R:L106	R:R:V52	2.98	No	No	0	8	6
226	R:R:L436	R:R:V439	2.98	No	No	0	7	7
227	R:R:L49	R:R:T48	2.95	No	Yes	0	5	4
228	R:R:I150	R:R:I234	2.94	No	No	0	8	9
229	R:R:I150	R:R:I237	2.94	No	No	0	8	7
230	R:R:I228	R:R:I395	2.94	No	No	0	6	7
231	R:R:P201	R:R:Y113	2.78	No	No	0	3	5
232	R:R:P182	R:R:Y211	2.78	No	Yes	0	8	8
233	R:R:A72	R:R:F452	2.77	No	Yes	0	9	8
234	R:R:E122	R:R:K118	2.7	No	No	0	7	4
235	R:R:L49	R:R:Q46	2.66	No	No	0	5	4
236	R:R:R163	R:R:T161	2.59	No	No	0	5	8
237	R:R:F74	R:R:I70	2.51	No	No	0	6	8
238	R:R:I237	R:R:R233	2.51	No	No	0	7	7
239	R:R:F444	R:R:I443	2.51	Yes	No	0	8	7
240	R:R:I205	R:R:Y409	2.42	No	Yes	0	7	8
241	R:R:M111	R:R:Y115	2.39	Yes	No	0	7	5
242	R:R:Q381	R:R:R378	2.34	No	No	0	6	6
243	R:R:N108	R:R:W114	2.26	No	Yes	0	8	8
244	R:R:H446	R:R:R449	2.26	No	No	0	6	9
245	R:R:G396	R:R:V399	1.84	No	No	0	7	7
246	R:R:G415	R:R:V414	1.84	No	No	0	3	5
247	R:R:A451	R:R:A72	1.79	No	No	0	8	9
248	R:R:G396	R:R:I395	1.76	No	No	0	7	7
249	R:R:G56	R:R:M59	1.75	No	No	0	6	7
250	R:R:G112	R:R:M111	1.75	No	Yes	0	6	7
251	R:R:C401	R:R:V400	1.71	No	No	0	8	5
252	R:R:C416	R:R:V414	1.71	No	No	0	8	5
253	R:R:A141	R:R:V172	1.7	No	No	0	8	8
254	R:R:G379	R:R:N382	1.7	No	No	0	4	5
255	R:R:S89	R:R:S92	1.63	No	No	0	9	7
256	R:R:C432	R:R:L58	1.59	No	No	0	7	7
257	R:R:T171	R:R:V174	1.59	No	No	0	5	5
258	R:R:A177	R:R:L130	1.58	No	No	0	7	7
259	R:R:I213	R:R:S214	1.55	No	No	0	7	7
260	R:R:I95	R:R:V63	1.54	No	No	0	8	7
261	R:R:I71	R:R:V67	1.54	No	No	0	7	6
262	R:R:I95	R:R:V67	1.54	No	No	0	8	6
263	R:R:I175	R:R:V137	1.54	No	No	0	7	7
264	R:R:I170	R:R:V174	1.54	No	No	0	5	5
265	R:R:F116	R:R:G117	1.51	Yes	No	0	7	7
266	R:R:A119	R:R:E122	1.51	No	No	0	5	7
267	R:R:G379	R:R:R378	1.5	No	No	0	4	6
268	R:R:L60	R:R:V63	1.49	No	No	0	6	7
269	R:R:L106	R:R:V110	1.49	No	No	0	8	7
270	R:R:I228	R:R:L229	1.43	No	No	0	6	5
271	R:R:D207	R:R:I205	1.4	No	No	0	5	7
272	R:R:L54	R:R:L57	1.38	No	No	0	5	5
273	R:R:L45	R:R:Q46	1.33	No	No	0	3	4
274	R:R:E109	R:R:L51	1.33	No	No	0	7	6
275	R:R:D447	R:R:H446	1.26	Yes	No	0	8	6
276	R:R:I237	R:R:R241	1.25	No	No	0	7	8
277	R:R:F74	R:R:K80	1.24	No	No	0	6	7
278	R:R:L391	R:R:Y235	1.17	No	Yes	0	8	8
279	R:R:F426	R:R:F429	1.07	Yes	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.86727	11	1	0
2	R:R:T48	5	4	0	4
3	R:R:N66	8.5225	4	0	9
4	R:R:L79	6.8775	4	0	9
5	R:R:Q83	6.7525	4	0	9
6	R:R:N84	4.4875	4	0	9
7	R:R:L100	5.17	4	1	7
8	R:R:V101	6.89	4	1	8
9	R:R:M111	3.175	4	0	7
10	R:R:W114	5.908	5	3	8
11	R:R:F116	5.51	4	3	7
12	R:R:F131	7.4	4	1	7
13	R:R:I136	4.62	4	1	9
14	R:R:H138	8.695	4	0	8
15	R:R:Y147	5.74	4	0	8
16	R:R:W148	6.8925	4	0	6
17	R:R:Y156	9.11	4	0	9
18	R:R:Y211	5.728	5	6	8
19	R:R:F220	9.03	6	1	9
20	R:R:Y231	5.77714	7	2	9
21	R:R:Y235	7.962	5	4	8
22	R:R:E384	7.55	5	4	9
23	R:R:F398	6.05	4	1	9
24	R:R:W402	6.8975	8	1	9
25	R:R:F405	9.7525	4	1	8
26	R:R:F406	10.582	5	1	8
27	R:R:Y409	6.416	5	1	8
28	R:R:P419	5.3875	4	1	7
29	R:R:F423	6.77	4	1	6
30	R:R:F426	9.3875	4	0	7
31	R:R:Y431	7.67714	7	1	8
32	R:R:Y441	7.67	4	2	9
33	R:R:F444	7.985	4	0	8
34	R:R:D447	3.4525	4	0	8
35	R:R:F448	7.955	4	5	8
36	R:R:F452	6.968	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y431	56.6428	10.14	Yes	Yes	1	0	8
2	R:R:W428	R:R:Y431	11.9188	6.75	No	Yes	0	7	8
3	R:R:E109	R:R:W428	11.095	9.81	No	No	0	7	7
4	R:R:E109	R:R:L51	10.3343	1.33	No	No	0	7	6
5	L:L:?1	R:R:D128	39.6768	4.89	Yes	No	1	0	8
6	R:R:D128	R:R:V101	39.8062	8.76	No	Yes	1	8	8
7	R:R:V101	R:R:V97	100	8.02	Yes	No	0	8	8
8	R:R:D94	R:R:V97	99.9463	4.38	No	No	0	9	8
9	R:R:D94	R:R:N66	99.0752	12.12	No	Yes	0	9	9
10	R:R:N66	R:R:P438	93.3178	13.03	Yes	No	0	9	9
11	R:R:N437	R:R:P438	92.7969	4.89	No	No	0	9	9
12	R:R:L139	R:R:N437	81.8535	6.87	No	No	2	8	9
13	R:R:L139	R:R:Y441	84.8142	10.55	No	Yes	2	8	9
14	R:R:I142	R:R:Y441	50.9106	4.84	No	Yes	2	9	9
15	R:R:F86	R:R:I142	53.0034	5.02	No	No	0	8	9
16	R:R:F86	R:R:I165	42.9058	8.79	No	No	0	8	8
17	R:R:I165	R:R:P82	39.8756	5.08	No	No	0	8	7
18	R:R:P82	R:R:Q83	36.2141	6.32	No	Yes	0	7	9
19	R:R:N84	R:R:Q83	36.1415	5.28	Yes	Yes	0	9	9
20	R:R:L79	R:R:N84	31.5962	4.12	Yes	Yes	0	9	9
21	R:R:F448	R:R:L79	22.13	7.31	Yes	Yes	0	8	9
22	R:R:F448	R:R:F452	10.047	4.29	Yes	Yes	5	8	8
23	R:R:V101	R:R:Y431	63.6691	6.31	Yes	Yes	1	8	8
24	R:R:F86	R:R:I168	10.5678	8.79	No	No	0	8	7
25	R:R:Y231	R:R:Y441	38.0607	3.97	Yes	Yes	2	9	9
26	R:R:V230	R:R:Y231	20.6812	5.05	No	Yes	2	8	9
27	R:R:V230	R:R:Y147	20.1446	6.31	No	Yes	0	8	8
28	R:R:W148	R:R:Y147	12.6511	4.82	Yes	Yes	0	6	8
29	R:R:L90	R:R:N437	10.4132	12.36	No	No	2	9	9
30	R:R:H138	R:R:L90	12.8784	5.14	Yes	No	0	8	9
31	R:R:S105	R:R:Y431	26.2397	6.36	No	Yes	0	8	8
32	R:R:S105	R:R:Y124	25.6053	3.82	No	No	0	8	7
33	R:R:W114	R:R:Y124	15.2741	7.72	Yes	No	3	8	7
34	R:R:F116	R:R:M111	11.5969	3.73	Yes	Yes	0	7	7
35	L:L:?1	R:R:S215	11.6126	3.25	Yes	No	0	0	9
36	L:L:?1	R:R:W402	28.323	4.93	Yes	Yes	1	0	9
37	L:L:?1	R:R:Y409	20.2929	5.92	Yes	Yes	1	0	8
38	L:L:?1	R:R:F406	21.8554	6.15	Yes	Yes	1	0	8
39	R:R:F220	R:R:W402	13.5381	4.01	Yes	Yes	1	9	9
40	R:R:F220	R:R:F406	14.0336	21.43	Yes	Yes	1	9	8
41	R:R:F220	R:R:F403	16.4357	7.5	Yes	No	0	9	7
42	R:R:L391	R:R:Y231	10.8235	5.86	No	Yes	0	8	9
43	R:R:F403	R:R:F407	14.1062	5.36	No	No	0	7	7
44	L:L:?1	R:R:F405	15.5298	11.42	Yes	Yes	1	0	8
45	R:R:F405	R:R:F423	15.9181	9.65	Yes	Yes	1	8	6
46	R:R:F423	R:R:T408	18.8851	6.49	Yes	No	1	6	7
47	R:R:F426	R:R:T408	16.6346	12.97	Yes	No	0	7	7
48	R:R:F423	R:R:Y409	14.7281	5.16	Yes	Yes	1	6	8
49	R:R:F407	R:R:L411	11.7705	15.83	No	No	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D128	4.89	1	Yes	No	0	8	0	1
L:L:?1	R:R:V129	21.48	1	Yes	No	0	8	0	1
L:L:?1	R:R:C132	10.3	1	Yes	No	0	7	0	1
L:L:?1	R:R:W402	4.93	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F405	11.42	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F406	6.15	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	5.92	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F427	15.81	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y431	10.14	1	Yes	Yes	0	8	0	1
R:R:D128	R:R:V101	8.76	1	No	Yes	8	8	1	2
R:R:V101	R:R:Y431	6.31	1	Yes	Yes	8	8	2	1
R:R:S105	R:R:Y431	6.36	0	No	Yes	8	8	2	1
R:R:D128	R:R:Y431	9.2	1	No	Yes	8	8	1	1
R:R:S180	R:R:V129	4.85	0	No	No	8	8	2	1
R:R:C132	R:R:W402	3.92	1	No	Yes	7	9	1	1
R:R:I179	R:R:T133	4.56	0	No	No	8	8	2	2
R:R:S219	R:R:T133	6.4	0	No	No	8	8	1	2
R:R:F398	R:R:I136	3.77	1	Yes	Yes	9	9	2	2
R:R:I136	R:R:W402	8.22	1	Yes	Yes	9	9	2	1
R:R:I179	R:R:S215	4.64	0	No	No	8	9	2	1
R:R:S215	R:R:Y211	5.09	0	No	Yes	9	8	1	2
R:R:V212	R:R:Y409	11.36	0	No	Yes	7	8	2	1
R:R:C216	R:R:F406	5.59	0	No	Yes	7	8	2	1
R:R:F220	R:R:F398	6.43	1	Yes	Yes	9	9	2	2
R:R:F220	R:R:W402	4.01	1	Yes	Yes	9	9	2	1
R:R:F220	R:R:F406	21.43	1	Yes	Yes	9	8	2	1
R:R:F398	R:R:W402	7.02	1	Yes	Yes	9	9	2	1
R:R:F406	R:R:W402	9.02	1	Yes	Yes	8	9	1	1
R:R:G430	R:R:W402	5.63	0	No	Yes	8	9	2	1
R:R:N433	R:R:W402	12.43	0	No	Yes	9	9	2	1
R:R:F405	R:R:F406	10.72	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:Y409	7.22	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:F423	9.65	1	Yes	Yes	8	6	1	2
R:R:F423	R:R:Y409	5.16	1	Yes	Yes	6	8	2	1
R:R:F427	R:R:Y431	11.35	1	No	Yes	7	8	1	1
R:R:W428	R:R:Y431	6.75	0	No	Yes	7	8	2	1
R:R:I102	R:R:Y431	3.63	0	No	Yes	8	8	2	1
L:L:?1	R:R:S215	3.25	1	Yes	No	0	9	0	1
L:L:?1	R:R:S219	3.25	1	Yes	No	0	8	0	1
R:R:I205	R:R:Y409	2.42	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9PLO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.73
Number of Linked Nodes	252
Number of Links	279
Number of Hubs	36
Number of Links mediated by Hubs	139
Number of Communities	6
Number of Nodes involved in Communities	47
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	52772
Length Of Smallest Path	3
Average Path Length	14.8202
Length of Longest Path	30
Minimum Path Strength	1.515
Average Path Strength	6.9218
Maximum Path Strength	18.645
Minimum Path Correlation	0.7
Average Path Correlation	0.924879
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	46.4338
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8148
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1C
Name	1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide
Synonyms
Identifier
Formula	C20 H23 Cl N2 O3 S
Molecular Weight	406.926
SMILES
PubChem	131800983
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>9PLO_nogp_Chain_R Y S L Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P P P R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R R W R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS-79948	-	-	2.7	2019-12-04	doi.org/10.1038/nature06325
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	doi.org/10.1038/nature06325
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-		3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	doi.org/10.1126/science.abn7065
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9IQR	A	Amine	Adrenegic	α_2a	Homo sapiens	-	Muscarinic toxin 3	-	3.4	2025-07-23	To be published
	9PLN	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-	-	2.8	2025-08-20	To be published
	9PQD	A	Amine	Adrenegic	α_2a	Homo sapiens	(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole	-	-	3.29	2025-08-20	To be published
	9PLO	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-	Go/β1/γ2	2.74	2025-08-20	To be published
	9PLO (No Gprot)	A	Amine	Adrenegic	α_2a	Homo sapiens	N-(5-methylnaphthalen-1-yl)pyridin-4-amine	-		2.74	2025-08-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9PLO_nogp.zip

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