psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D128	16.56	Yes	No	1	0	8
2	L:L:?1	R:R:V129	13.98	Yes	No	1	0	8
3	L:L:?1	R:R:C132	7.45	Yes	No	1	0	7
4	L:L:?1	R:R:T133	4.15	Yes	Yes	1	0	8
5	L:L:?1	R:R:I205	2.68	Yes	No	1	0	7
6	L:L:?1	R:R:S215	7.05	Yes	No	0	0	9
7	L:L:?1	R:R:S219	4.23	Yes	No	1	0	8
8	L:L:?1	R:R:W402	3.21	Yes	Yes	1	0	9
9	L:L:?1	R:R:F405	11.43	Yes	No	1	0	8
10	L:L:?1	R:R:F406	9.15	Yes	Yes	1	0	8
11	L:L:?1	R:R:Y409	4.4	Yes	Yes	1	0	8
12	L:L:?1	R:R:F427	6.86	Yes	Yes	1	0	7
13	L:L:?1	R:R:Y431	8.8	Yes	Yes	1	0	8
14	R:R:L45	R:R:Q46	5.32	No	No	0	3	4
15	R:R:L45	R:R:V47	2.98	No	No	0	3	5
16	R:R:T48	R:R:V110	3.17	No	No	0	4	7
17	R:R:L51	R:R:T50	4.42	No	No	0	6	3
18	R:R:L106	R:R:V52	4.47	No	No	0	8	6
19	R:R:A55	R:R:L106	6.3	No	No	0	5	8
20	R:R:L57	R:R:L61	5.54	No	No	0	5	5
21	R:R:C432	R:R:L58	6.35	No	No	0	7	7
22	R:R:M59	R:R:P103	3.35	No	No	0	7	9
23	R:R:N66	R:R:T62	4.39	Yes	No	0	9	8
24	R:R:A98	R:R:T62	5.03	No	No	0	9	8
25	R:R:S435	R:R:T62	4.8	No	No	0	8	8
26	R:R:F64	R:R:L68	3.65	No	Yes	0	5	8
27	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
28	R:R:D94	R:R:N66	12.12	Yes	Yes	2	9	9
29	R:R:I95	R:R:N66	4.25	No	Yes	0	8	9
30	R:R:N66	R:R:P438	8.15	Yes	No	2	9	9
31	R:R:I95	R:R:V67	3.07	No	No	0	8	6
32	R:R:F452	R:R:L68	10.96	No	Yes	0	8	8
33	R:R:I455	R:R:L68	2.85	No	Yes	0	8	8
34	R:R:T442	R:R:V69	3.17	No	No	0	9	9
35	R:R:A91	R:R:I70	3.25	No	No	0	9	8
36	R:R:I455	R:R:I71	4.42	No	No	0	8	7
37	R:R:A72	R:R:F452	2.77	No	No	0	9	8
38	R:R:V73	R:R:V88	4.81	No	No	0	8	7
39	R:R:F448	R:R:V73	2.62	Yes	No	0	8	8
40	R:R:F74	R:R:V88	2.62	No	No	0	6	7
41	R:R:L79	R:R:S76	9.01	Yes	No	0	9	8
42	R:R:K80	R:R:R77	7.43	No	No	0	7	8
43	R:R:A78	R:R:D447	4.63	No	Yes	0	7	8
44	R:R:L79	R:R:N84	2.75	Yes	No	0	9	9
45	R:R:D447	R:R:L79	2.71	Yes	Yes	0	8	9
46	R:R:F448	R:R:L79	13.4	Yes	Yes	0	8	9
47	R:R:A451	R:R:L79	3.15	No	Yes	0	8	9
48	R:R:A81	R:R:N84	3.13	No	No	0	8	9
49	R:R:N84	R:R:Q83	5.28	No	No	0	9	9
50	R:R:D145	R:R:Q83	9.14	No	No	3	9	9
51	R:R:Q83	R:R:R160	7.01	No	Yes	3	9	7
52	R:R:I165	R:R:L85	5.71	No	No	0	8	8
53	R:R:A141	R:R:F86	2.77	No	Yes	0	8	8
54	R:R:F86	R:R:I142	3.77	Yes	No	0	8	9
55	R:R:F86	R:R:I165	7.54	Yes	No	0	8	8
56	R:R:F86	R:R:I168	6.28	Yes	No	0	8	7
57	R:R:F448	R:R:L87	3.65	Yes	No	0	8	8
58	R:R:H138	R:R:S89	11.16	Yes	No	2	8	9
59	R:R:I169	R:R:S89	4.64	No	No	0	8	9
60	R:R:S89	R:R:W173	6.18	No	Yes	2	9	9
61	R:R:D94	R:R:L90	6.79	Yes	No	2	9	9
62	R:R:L90	R:R:S135	3	No	No	2	9	9
63	R:R:H138	R:R:L90	2.57	Yes	No	2	8	9
64	R:R:A93	R:R:W173	2.59	No	Yes	0	8	9
65	R:R:D94	R:R:S135	4.42	Yes	No	2	9	9
66	R:R:D94	R:R:S434	4.42	Yes	No	0	9	9
67	R:R:D94	R:R:P438	3.22	Yes	No	2	9	9
68	R:R:F131	R:R:L96	13.4	Yes	No	0	7	8
69	R:R:F131	R:R:V97	5.24	Yes	No	0	7	8
70	R:R:A98	R:R:I102	3.25	No	No	0	9	8
71	R:R:L100	R:R:T99	2.95	No	No	0	7	6
72	R:R:S105	R:R:V101	3.23	Yes	Yes	1	8	8
73	R:R:V101	R:R:Y124	3.79	Yes	Yes	1	8	7
74	R:R:D128	R:R:V101	4.38	No	Yes	1	8	8
75	R:R:V101	R:R:Y431	6.31	Yes	Yes	1	8	8
76	R:R:I102	R:R:P103	3.39	No	No	0	8	9
77	R:R:F104	R:R:Y124	4.13	No	Yes	0	7	7
78	R:R:S105	R:R:Y124	5.09	Yes	Yes	1	8	7
79	R:R:F427	R:R:S105	5.28	Yes	Yes	1	7	8
80	R:R:S105	R:R:Y431	6.36	Yes	Yes	1	8	8
81	R:R:C203	R:R:N108	4.72	No	No	0	9	8
82	R:R:E109	R:R:K424	6.75	No	No	0	7	7
83	R:R:M111	R:R:Y113	3.59	Yes	No	4	7	5
84	R:R:M111	R:R:Y115	5.99	Yes	No	4	7	5
85	R:R:W114	R:R:Y113	29.9	No	No	0	8	5
86	R:R:Y113	R:R:Y115	11.91	No	No	4	5	5
87	R:R:R202	R:R:W114	18.99	No	No	0	5	8
88	R:R:F116	R:R:W120	9.02	No	No	0	7	6
89	R:R:E122	R:R:K118	6.75	No	No	0	7	4
90	R:R:C121	R:R:E122	4.56	No	No	0	9	7
91	R:R:C121	R:R:C203	5.46	No	No	0	9	9
92	R:R:F131	R:R:L127	6.09	Yes	No	0	7	7
93	R:R:D128	R:R:Y431	8.05	No	Yes	1	8	8
94	R:R:T133	R:R:V129	3.17	Yes	No	1	8	8
95	R:R:S180	R:R:V129	6.46	No	No	0	8	8
96	R:R:L130	R:R:S176	3	No	No	0	7	8
97	R:R:L130	R:R:S180	4.5	No	No	0	7	8
98	R:R:F131	R:R:W173	3.01	Yes	Yes	0	7	9
99	R:R:C132	R:R:W402	3.92	No	Yes	1	7	9
100	R:R:I179	R:R:T133	3.04	No	Yes	0	8	8
101	R:R:S219	R:R:T133	7.99	No	Yes	1	8	8
102	R:R:H138	R:R:S134	2.79	Yes	No	2	8	8
103	R:R:S134	R:R:W173	11.12	No	Yes	2	8	9
104	R:R:S134	R:R:S176	6.52	No	No	2	8	8
105	R:R:I136	R:R:P223	3.39	No	No	0	9	9
106	R:R:I136	R:R:W402	14.09	No	Yes	0	9	9
107	R:R:V137	R:R:V172	3.21	No	No	0	7	8
108	R:R:H138	R:R:V172	4.15	Yes	No	0	8	8
109	R:R:H138	R:R:W173	4.23	Yes	Yes	2	8	9
110	R:R:L139	R:R:M227	2.83	No	Yes	0	8	9
111	R:R:L139	R:R:N437	5.49	No	No	0	8	9
112	R:R:L139	R:R:Y441	7.03	No	Yes	0	8	9
113	R:R:C140	R:R:L144	3.17	No	No	5	7	7
114	R:R:C140	R:R:I226	3.27	No	No	5	7	8
115	R:R:I142	R:R:R146	3.76	No	Yes	1	9	9
116	R:R:I142	R:R:Y441	4.84	No	Yes	1	9	9
117	R:R:S143	R:R:V230	8.08	No	No	0	9	8
118	R:R:S143	R:R:Y231	3.82	No	Yes	0	9	9
119	R:R:I226	R:R:L144	2.85	No	No	5	8	7
120	R:R:D145	R:R:Y156	10.34	No	Yes	3	9	9
121	R:R:D145	R:R:R160	7.15	No	Yes	3	9	7
122	R:R:R146	R:R:Y231	6.17	Yes	Yes	1	9	9
123	R:R:R146	R:R:Y441	6.17	Yes	Yes	1	9	9
124	R:R:W148	R:R:Y147	4.82	No	Yes	0	6	8
125	R:R:T151	R:R:Y147	13.73	No	Yes	0	7	8
126	R:R:V230	R:R:Y147	2.52	No	Yes	0	8	8
127	R:R:R233	R:R:Y147	5.14	No	Yes	0	7	8
128	R:R:Q152	R:R:W148	3.29	No	No	0	7	6
129	R:R:W148	R:R:Y156	11.58	No	Yes	0	6	9
130	R:R:R160	R:R:S149	6.59	Yes	No	0	7	9
131	R:R:K159	R:R:Y156	4.78	No	Yes	0	6	9
132	R:R:R160	R:R:Y156	8.23	Yes	Yes	3	7	9
133	R:R:P162	R:R:T161	5.25	No	No	0	6	8
134	R:R:R163	R:R:T161	3.88	No	No	0	5	8
135	R:R:R164	R:R:T161	2.59	No	No	0	8	8
136	R:R:I175	R:R:T171	3.04	No	No	0	7	5
137	R:R:S176	R:R:W173	4.94	No	Yes	2	8	9
138	R:R:A177	R:R:F181	2.77	No	No	0	7	6
139	R:R:I179	R:R:S215	3.1	No	No	0	8	9
140	R:R:D207	R:R:I205	4.2	No	No	1	5	7
141	R:R:I205	R:R:Y409	7.25	No	Yes	1	7	8
142	R:R:N206	R:R:Q208	2.64	No	No	6	7	6
143	R:R:N206	R:R:Y211	4.65	No	Yes	6	7	8
144	R:R:D207	R:R:Y409	5.75	No	Yes	1	5	8
145	R:R:Q208	R:R:Y211	9.02	No	Yes	6	6	8
146	R:R:Q208	R:R:V212	4.3	No	No	0	6	7
147	R:R:S214	R:R:W210	4.94	No	No	0	7	5
148	R:R:S214	R:R:Y211	3.82	No	Yes	0	7	8
149	R:R:S215	R:R:Y211	8.9	No	Yes	0	9	8
150	R:R:I213	R:R:I217	2.94	No	No	0	7	6
151	R:R:A413	R:R:I213	3.25	No	No	0	7	7
152	R:R:C216	R:R:F406	2.79	No	Yes	0	7	8
153	R:R:C216	R:R:T410	5.07	No	No	0	7	7
154	R:R:F221	R:R:I217	3.77	No	No	0	7	6
155	R:R:F406	R:R:S219	2.64	Yes	No	1	8	8
156	R:R:F220	R:R:F221	4.29	Yes	No	0	9	7
157	R:R:C224	R:R:F220	8.38	No	Yes	1	7	9
158	R:R:F220	R:R:F398	6.43	Yes	Yes	1	9	9
159	R:R:F220	R:R:W402	5.01	Yes	Yes	1	9	9
160	R:R:F220	R:R:F403	7.5	Yes	No	0	9	7
161	R:R:F220	R:R:F406	15	Yes	Yes	1	9	8
162	R:R:F221	R:R:T410	2.59	No	No	0	7	7
163	R:R:A222	R:R:P223	3.74	No	No	0	6	9
164	R:R:C224	R:R:F398	6.98	No	Yes	1	7	9
165	R:R:L225	R:R:L229	4.15	No	No	0	5	5
166	R:R:M227	R:R:Y231	4.79	Yes	Yes	1	9	9
167	R:R:I395	R:R:M227	2.92	No	Yes	1	7	9
168	R:R:F398	R:R:M227	8.71	Yes	Yes	1	9	9
169	R:R:L391	R:R:Y231	3.52	No	Yes	0	8	9
170	R:R:V394	R:R:Y231	3.79	No	Yes	0	8	9
171	R:R:I395	R:R:Y231	7.25	No	Yes	1	7	9
172	R:R:Y231	R:R:Y441	2.98	Yes	Yes	1	9	9
173	R:R:K239	R:R:Y235	9.55	No	Yes	7	8	8
174	R:R:E384	R:R:Y235	3.37	Yes	Yes	7	9	8
175	R:R:A238	R:R:F387	4.16	No	No	0	8	8
176	R:R:E384	R:R:K239	10.8	Yes	No	7	9	8
177	R:R:K385	R:R:Q381	10.85	No	No	0	7	6
178	R:R:N382	R:R:R383	13.26	No	No	0	5	8
179	R:R:N382	R:R:R386	6.03	No	No	0	5	9
180	R:R:F387	R:R:R383	6.41	No	No	0	8	8
181	R:R:E384	R:R:T388	4.23	Yes	No	0	9	8
182	R:R:K385	R:R:R386	4.95	No	No	0	7	9
183	R:R:F389	R:R:V393	7.87	No	No	0	7	7
184	R:R:L391	R:R:V390	2.98	No	No	0	8	8
185	R:R:F444	R:R:V390	15.73	No	No	0	8	8
186	R:R:I440	R:R:V393	3.07	Yes	No	0	8	7
187	R:R:I440	R:R:V394	3.07	Yes	No	0	8	8
188	R:R:I440	R:R:V397	6.14	Yes	No	0	8	8
189	R:R:F398	R:R:V399	3.93	Yes	No	0	9	7
190	R:R:C401	R:R:N433	12.6	No	No	0	8	9
191	R:R:G430	R:R:W402	7.04	No	Yes	0	8	9
192	R:R:N433	R:R:W402	9.04	No	Yes	0	9	9
193	R:R:F403	R:R:F407	4.29	No	No	0	7	7
194	R:R:F426	R:R:P404	10.11	Yes	No	0	7	9
195	R:R:F405	R:R:Y409	7.22	No	Yes	1	8	8
196	R:R:F407	R:R:L411	13.4	No	No	0	7	7
197	R:R:F423	R:R:T408	10.38	No	No	0	6	7
198	R:R:F426	R:R:T408	7.78	Yes	No	0	7	7
199	R:R:L411	R:R:S417	12.01	No	No	0	7	1
200	R:R:F423	R:R:T412	5.19	No	No	0	6	5
201	R:R:F423	R:R:V418	5.24	No	No	0	6	6
202	R:R:R420	R:R:T421	9.06	No	No	0	4	5
203	R:R:F426	R:R:L422	7.31	Yes	No	0	7	7
204	R:R:F426	R:R:F429	3.22	Yes	No	1	7	8
205	R:R:F427	R:R:W428	11.02	Yes	No	0	7	7
206	R:R:F427	R:R:Y431	16.5	Yes	Yes	1	7	8
207	R:R:N433	R:R:N437	10.9	No	No	0	9	9
208	R:R:I440	R:R:V439	3.07	Yes	No	0	8	7
209	R:R:F448	R:R:T442	7.78	Yes	No	0	8	9
210	R:R:F452	R:R:T442	6.49	No	No	0	8	9
211	R:R:F444	R:R:I443	6.28	No	No	0	8	7
212	R:R:D447	R:R:N445	4.04	Yes	No	0	8	9
213	R:R:F448	R:R:N445	8.46	Yes	No	0	8	9
214	R:R:D447	R:R:H446	2.52	Yes	No	0	8	6
215	R:R:L125	R:R:Y124	2.34	No	Yes	0	7	7
216	R:R:L391	R:R:Y235	2.34	No	Yes	0	8	8
217	R:R:K209	R:R:W210	2.32	No	No	0	5	5
218	R:R:E109	R:R:W428	2.18	No	No	0	7	7
219	R:R:F405	R:R:F426	2.14	No	Yes	1	8	7
220	R:R:F425	R:R:F426	2.14	No	Yes	1	6	7
221	R:R:F425	R:R:F429	2.14	No	No	1	6	8
222	R:R:R240	R:R:R241	2.13	No	No	0	7	8
223	R:R:F116	R:R:Y115	2.06	No	No	0	7	5
224	R:R:A55	R:R:G56	1.95	No	No	0	5	6
225	R:R:P162	R:R:P82	1.95	No	No	0	6	7
226	R:R:P182	R:R:P183	1.95	No	No	0	8	8
227	R:R:C140	R:R:P223	1.88	No	No	0	7	9
228	R:R:A81	R:R:P82	1.87	No	No	0	8	7
229	R:R:G415	R:R:V414	1.84	No	No	0	3	5
230	R:R:P419	R:R:V418	1.77	No	No	0	7	6
231	R:R:G396	R:R:I395	1.76	No	No	0	7	7
232	R:R:G56	R:R:M59	1.75	No	No	0	6	7
233	R:R:G112	R:R:M111	1.75	No	Yes	0	6	7
234	R:R:G65	R:R:L68	1.71	No	Yes	0	9	8
235	R:R:A126	R:R:S180	1.71	No	No	0	8	8
236	R:R:C401	R:R:V400	1.71	No	No	0	8	5
237	R:R:A413	R:R:V414	1.7	No	No	0	7	5
238	R:R:T48	R:R:V47	1.59	No	No	0	4	5
239	R:R:T171	R:R:V172	1.59	No	No	0	5	8
240	R:R:C401	R:R:L436	1.59	No	No	0	8	7
241	R:R:C432	R:R:L436	1.59	No	No	0	7	7
242	R:R:C457	R:R:L456	1.59	No	No	0	6	8
243	R:R:A177	R:R:L130	1.58	No	No	0	7	7
244	R:R:I170	R:R:V174	1.54	No	No	0	5	5
245	R:R:I228	R:R:V232	1.54	No	No	0	6	4
246	R:R:M59	R:R:V63	1.52	No	No	0	7	7
247	R:R:M111	R:R:V110	1.52	Yes	No	0	7	7
248	R:R:G379	R:R:R383	1.5	No	No	0	4	8
249	R:R:L60	R:R:V63	1.49	No	No	0	6	7
250	R:R:L100	R:R:V101	1.49	No	Yes	0	7	8
251	R:R:L49	R:R:T48	1.47	No	No	0	5	4
252	R:R:I150	R:R:I234	1.47	No	No	0	8	9
253	R:R:I150	R:R:I237	1.47	No	No	0	8	7
254	R:R:F181	R:R:P182	1.44	No	No	0	6	8
255	R:R:I228	R:R:L229	1.43	No	No	0	6	5
256	R:R:K166	R:R:L85	1.41	No	No	0	6	8
257	R:R:E155	R:R:I154	1.37	No	No	0	6	7
258	R:R:C121	R:R:Y124	1.34	No	Yes	0	9	7
259	R:R:C203	R:R:W114	1.31	No	No	0	9	8
260	R:R:I234	R:R:R146	1.25	No	Yes	0	9	9
261	R:R:I443	R:R:R449	1.25	No	No	0	7	9
262	R:R:L229	R:R:R233	1.21	No	No	0	5	7
263	R:R:E384	R:R:F387	1.17	Yes	No	0	9	8
264	R:R:Q236	R:R:Y235	1.13	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.68846	13	1	0
2	R:R:N66	6.72	5	2	9
3	R:R:L68	4.7925	4	0	8
4	R:R:L79	6.204	5	0	9
5	R:R:F86	5.09	4	0	8
6	R:R:D94	6.194	5	2	9
7	R:R:V101	3.84	5	1	8
8	R:R:S105	4.99	4	1	8
9	R:R:M111	3.2125	4	4	7
10	R:R:Y124	3.338	5	1	7
11	R:R:F131	6.935	4	0	7
12	R:R:T133	4.5875	4	1	8
13	R:R:H138	4.98	5	2	8
14	R:R:R146	4.3375	4	1	9
15	R:R:Y147	6.5525	4	0	8
16	R:R:Y156	8.7325	4	3	9
17	R:R:R160	7.245	4	3	7
18	R:R:W173	5.345	6	2	9
19	R:R:Y211	6.5975	4	6	8
20	R:R:F220	7.76833	6	1	9
21	R:R:M227	4.8125	4	1	9
22	R:R:Y231	4.61714	7	1	9
23	R:R:Y235	4.0975	4	7	8
24	R:R:E384	4.8925	4	7	9
25	R:R:F398	6.5125	4	1	9
26	R:R:W402	7.05167	6	1	9
27	R:R:F406	7.395	4	1	8
28	R:R:Y409	6.155	4	1	8
29	R:R:F426	5.45	6	1	7
30	R:R:F427	9.915	4	1	7
31	R:R:Y431	9.204	5	1	8
32	R:R:I440	3.8375	4	0	8
33	R:R:Y441	5.255	4	1	9
34	R:R:D447	3.475	4	0	8
35	R:R:F448	7.182	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D128	20.601	16.56	Yes	No	1	0	8
2	R:R:D128	R:R:V101	19.9275	4.38	No	Yes	1	8	8
3	R:R:V101	R:R:Y124	35.1646	3.79	Yes	Yes	1	8	7
4	R:R:C121	R:R:Y124	61.1359	1.34	No	Yes	0	9	7
5	R:R:C121	R:R:C203	51.5333	5.46	No	No	0	9	9
6	R:R:C203	R:R:W114	45.1103	1.31	No	No	0	9	8
7	R:R:W114	R:R:Y113	38.6702	29.9	No	No	0	8	5
8	R:R:M111	R:R:Y113	25.6878	3.59	Yes	No	4	7	5
9	R:R:M111	R:R:V110	19.2456	1.52	Yes	No	0	7	7
10	R:R:T48	R:R:V110	15.9936	3.17	No	No	0	4	7
11	L:L:?1	R:R:Y431	38.7725	8.8	Yes	Yes	1	0	8
12	R:R:V101	R:R:Y431	19.8636	6.31	Yes	Yes	1	8	8
13	L:L:?1	R:R:F427	21.2445	6.86	Yes	Yes	1	0	7
14	R:R:F427	R:R:S105	18.406	5.28	Yes	Yes	1	7	8
15	R:R:S105	R:R:Y124	35.2094	5.09	Yes	Yes	1	8	7
16	R:R:S105	R:R:Y431	18.2355	6.36	Yes	Yes	1	8	8
17	L:L:?1	R:R:V129	61.8327	13.98	Yes	No	1	0	8
18	R:R:S180	R:R:V129	61.5791	6.46	No	No	0	8	8
19	R:R:L130	R:R:S180	60.1385	4.5	No	No	0	7	8
20	R:R:L130	R:R:S176	56.4624	3	No	No	0	7	8
21	R:R:S134	R:R:S176	24.7608	6.52	No	No	2	8	8
22	R:R:H138	R:R:S134	23.9382	2.79	Yes	No	2	8	8
23	R:R:H138	R:R:L90	39.5674	2.57	Yes	No	2	8	9
24	R:R:D94	R:R:L90	36.0128	6.79	Yes	No	2	9	9
25	R:R:D94	R:R:N66	30.7192	12.12	Yes	Yes	2	9	9
26	R:R:N66	R:R:T62	21.837	4.39	Yes	No	0	9	8
27	R:R:A98	R:R:T62	18.2397	5.03	No	No	0	9	8
28	R:R:A98	R:R:I102	16.4347	3.25	No	No	0	9	8
29	R:R:I102	R:R:P103	14.6255	3.39	No	No	0	8	9
30	R:R:M59	R:R:P103	12.8119	3.35	No	No	0	7	9
31	R:R:S176	R:R:W173	30.9515	4.94	No	Yes	2	8	9
32	R:R:H138	R:R:W173	24.2216	4.23	Yes	Yes	2	8	9
33	L:L:?1	R:R:W402	63.6761	3.21	Yes	Yes	1	0	9
34	R:R:F220	R:R:W402	54.3335	5.01	Yes	Yes	1	9	9
35	R:R:F220	R:R:F398	100	6.43	Yes	Yes	1	9	9
36	R:R:F398	R:R:M227	99.0005	8.71	Yes	Yes	1	9	9
37	R:R:M227	R:R:Y231	97.8732	4.79	Yes	Yes	1	9	9
38	R:R:S143	R:R:Y231	79.1305	3.82	No	Yes	0	9	9
39	R:R:S143	R:R:V230	78.2376	8.08	No	No	0	9	8
40	R:R:V230	R:R:Y147	77.3213	2.52	No	Yes	0	8	8
41	R:R:W148	R:R:Y147	71.0069	4.82	No	Yes	0	6	8
42	R:R:W148	R:R:Y156	69.1401	11.58	No	Yes	0	6	9
43	R:R:D145	R:R:Y156	33.0783	10.34	No	Yes	3	9	9
44	R:R:D145	R:R:Q83	32.0554	9.14	No	No	3	9	9
45	R:R:N84	R:R:Q83	62.2845	5.28	No	No	0	9	9
46	R:R:L79	R:R:N84	47.4267	2.75	Yes	No	0	9	9
47	R:R:F448	R:R:L79	32.5392	13.4	Yes	Yes	0	8	9
48	R:R:F448	R:R:T442	19.5269	7.78	Yes	No	0	8	9
49	R:R:F452	R:R:T442	15.3266	6.49	No	No	0	8	9
50	R:R:F452	R:R:L68	10.9068	10.96	No	Yes	0	8	8
51	L:L:?1	R:R:F406	53.0847	9.15	Yes	Yes	1	0	8
52	R:R:F220	R:R:F406	53.2339	15	Yes	Yes	1	9	8
53	R:R:R160	R:R:Y156	34.1588	8.23	Yes	Yes	3	7	9
54	R:R:Q83	R:R:R160	32.2259	7.01	No	Yes	3	9	7
55	R:R:A81	R:R:N84	13.3085	3.13	No	No	0	8	9
56	R:R:A81	R:R:P82	11.1007	1.87	No	No	0	8	7
57	R:R:L391	R:R:Y231	20.8205	3.52	No	Yes	0	8	9
58	R:R:L391	R:R:Y235	15.301	2.34	No	Yes	0	8	8
59	R:R:E384	R:R:Y235	11.7848	3.37	Yes	Yes	7	9	8
60	L:L:?1	R:R:F405	10.8748	11.43	Yes	No	1	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D128	16.56	1	Yes	No	0	8	0	1
L:L:?1	R:R:V129	13.98	1	Yes	No	0	8	0	1
L:L:?1	R:R:C132	7.45	1	Yes	No	0	7	0	1
L:L:?1	R:R:T133	4.15	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I205	2.68	1	Yes	No	0	7	0	1
L:L:?1	R:R:S215	7.05	1	Yes	No	0	9	0	1
L:L:?1	R:R:S219	4.23	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	3.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F405	11.43	1	Yes	No	0	8	0	1
L:L:?1	R:R:F406	9.15	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	4.4	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F427	6.86	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y431	8.8	1	Yes	Yes	0	8	0	1
R:R:S105	R:R:V101	3.23	1	Yes	Yes	8	8	2	2
R:R:D128	R:R:V101	4.38	1	No	Yes	8	8	1	2
R:R:V101	R:R:Y431	6.31	1	Yes	Yes	8	8	2	1
R:R:F427	R:R:S105	5.28	1	Yes	Yes	7	8	1	2
R:R:S105	R:R:Y431	6.36	1	Yes	Yes	8	8	2	1
R:R:D128	R:R:Y431	8.05	1	No	Yes	8	8	1	1
R:R:T133	R:R:V129	3.17	1	Yes	No	8	8	1	1
R:R:S180	R:R:V129	6.46	0	No	No	8	8	2	1
R:R:C132	R:R:W402	3.92	1	No	Yes	7	9	1	1
R:R:I179	R:R:T133	3.04	0	No	Yes	8	8	2	1
R:R:S219	R:R:T133	7.99	1	No	Yes	8	8	1	1
R:R:I136	R:R:W402	14.09	0	No	Yes	9	9	2	1
R:R:I179	R:R:S215	3.1	0	No	No	8	9	2	1
R:R:D207	R:R:I205	4.2	1	No	No	5	7	2	1
R:R:I205	R:R:Y409	7.25	1	No	Yes	7	8	1	1
R:R:D207	R:R:Y409	5.75	1	No	Yes	5	8	2	1
R:R:S215	R:R:Y211	8.9	0	No	Yes	9	8	1	2
R:R:C216	R:R:F406	2.79	0	No	Yes	7	8	2	1
R:R:F406	R:R:S219	2.64	1	Yes	No	8	8	1	1
R:R:F220	R:R:W402	5.01	1	Yes	Yes	9	9	2	1
R:R:F220	R:R:F406	15	1	Yes	Yes	9	8	2	1
R:R:G430	R:R:W402	7.04	0	No	Yes	8	9	2	1
R:R:N433	R:R:W402	9.04	0	No	Yes	9	9	2	1
R:R:F405	R:R:Y409	7.22	1	No	Yes	8	8	1	1
R:R:F427	R:R:W428	11.02	1	Yes	No	7	7	1	2
R:R:F427	R:R:Y431	16.5	1	Yes	Yes	7	8	1	1
R:R:F405	R:R:F426	2.14	1	No	Yes	8	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W7E_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	238
Number of Links	264
Number of Hubs	35
Number of Links mediated by Hubs	140
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	80754
Length Of Smallest Path	3
Average Path Length	17.5637
Length of Longest Path	39
Minimum Path Strength	1.32
Average Path Strength	6.24468
Maximum Path Strength	24.445
Minimum Path Correlation	0.7
Average Path Correlation	0.928106
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	36.3888
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4978
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • thioesterase binding • adrenergic receptor binding • signaling receptor binding • alpha-1B adrenergic receptor binding • G protein-coupled receptor binding • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • identical protein binding • protein homodimerization activity • kinase binding • protein kinase binding • alpha-2C adrenergic receptor binding • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • epinephrine binding • hormone binding • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • receptor transactivation • positive regulation of signaling receptor activity • regulation of signaling receptor activity • regulation of signal transduction • positive regulation of molecular function • regulation of molecular function • regulation of response to stimulus • positive regulation of response to wounding • wound healing • positive regulation of biological process • regulation of response to wounding • positive regulation of response to stimulus • positive regulation of wound healing • response to stress • regulation of response to stress • regulation of wound healing • response to wounding • regulation of protein modification process • positive regulation of phosphorylation • regulation of catalytic activity • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • activation of protein kinase B activity • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • positive regulation of cellular process • protein phosphorylation • positive regulation of transferase activity • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • positive regulation of catalytic activity • primary metabolic process • regulation of protein kinase activity • regulation of macromolecule metabolic process • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • thermoception • sensory perception of temperature stimulus • digestion • intestinal absorption • digestive system process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cell communication • positive regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • positive regulation of signaling • fear response • multicellular organismal response to stress • regulation of localization • regulation of calcium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of biological process • negative regulation of transport • establishment of localization • calcium ion transport • metal ion transport • negative regulation of calcium ion transport • localization • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of cellular process • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of body fluid levels • cell activation • hemostasis • blood coagulation • coagulation • platelet activation • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • response to morphine • response to isoquinoline alkaloid • response to alkaloid • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of membrane protein ectodomain proteolysis • macromolecule catabolic process • regulation of proteolysis • proteolysis • membrane protein proteolysis • membrane protein ectodomain proteolysis • regulation of membrane protein ectodomain proteolysis • protein catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • positive regulation of proteolysis • regulation of protein catabolic process • Rho protein signal transduction • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of uterine smooth muscle contraction • negative regulation of uterine smooth muscle contraction • negative regulation of smooth muscle contraction • negative regulation of multicellular organismal process • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • nucleobase-containing compound metabolic process • DNA replication • DNA metabolic process • nucleic acid metabolic process • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • regulation of calcium ion transmembrane transporter activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • negative regulation of transmembrane transport • regulation of transporter activity • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cation transmembrane transport • regulation of monoatomic ion transmembrane transporter activity • negative regulation of transporter activity • negative regulation of molecular function • inorganic ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • protein localization • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • signal release • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • regulation of MAP kinase activity • positive regulation of protein serine/threonine kinase activity • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of protein serine/threonine kinase activity • regulation of intracellular signal transduction • MAPK cascade • establishment of localization in cell • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • response to glucose • insulin secretion involved in cellular response to glucose stimulus • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • negative regulation of response to stimulus • negative regulation of insulin secretion involved in cellular response to glucose stimulus • cellular response to glucose stimulus • response to hexose • cellular homeostasis • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • organic hydroxy compound transport • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • positive regulation of macromolecule biosynthetic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • positive regulation of cytokine production • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • postsynaptic density • neuron to neuron synapse • asymmetric synapse • basal part of cell • basal plasma membrane • basolateral plasma membrane • dopaminergic synapse • receptor complex • neuronal cell body • presynaptic active zone membrane • presynaptic active zone • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	W58
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	W58
Name	5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine
Synonyms
Identifier
Formula	C13 H15 N
Molecular Weight	185.265
SMILES
PubChem	164946676
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>7W7E_nogp_Chain_R L Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P P R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	10.1126/science.abn7065
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	10.1126/science.abn7065
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	10.1126/sciadv.abj5347
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-		3.2	2022-04-13	10.1126/sciadv.abj5347
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	10.1038/nature06325
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS-79948	-	-	2.7	2019-12-04	10.1038/nature06325

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