psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L45	R:R:Y43	7.03	No	No	0	3	6
2	R:R:L49	R:R:Q46	2.66	No	No	0	5	4
3	R:R:T50	R:R:V47	3.17	No	No	0	3	5
4	R:R:L49	R:R:T50	4.42	No	No	0	5	3
5	R:R:L51	R:R:L54	4.15	No	No	0	6	5
6	R:R:K424	R:R:L51	7.05	No	No	0	7	6
7	R:R:L106	R:R:V52	7.45	No	No	0	8	6
8	R:R:A55	R:R:W428	2.59	No	No	0	5	7
9	R:R:L57	R:R:L61	5.54	No	No	0	5	5
10	R:R:L58	R:R:S435	4.5	No	No	0	7	8
11	R:R:I102	R:R:M59	5.83	No	No	0	8	7
12	R:R:N66	R:R:T62	4.39	Yes	Yes	8	9	8
13	R:R:D94	R:R:T62	4.34	Yes	Yes	8	9	8
14	R:R:S435	R:R:T62	4.8	No	Yes	0	8	8
15	R:R:D94	R:R:N66	13.46	Yes	Yes	8	9	9
16	R:R:I95	R:R:N66	5.66	No	Yes	0	8	9
17	R:R:N66	R:R:P438	6.52	Yes	No	0	9	9
18	R:R:F452	R:R:L68	7.31	Yes	No	0	8	8
19	R:R:T442	R:R:V69	3.17	Yes	Yes	5	9	9
20	R:R:F448	R:R:V69	2.62	Yes	Yes	5	8	9
21	R:R:F452	R:R:V69	5.24	Yes	Yes	5	8	9
22	R:R:F74	R:R:I70	2.51	No	No	0	6	8
23	R:R:I70	R:R:V88	4.61	No	No	0	8	7
24	R:R:A91	R:R:I70	3.25	No	No	0	9	8
25	R:R:I455	R:R:I71	2.94	No	No	0	8	7
26	R:R:A72	R:R:F452	4.16	No	Yes	0	9	8
27	R:R:N84	R:R:V73	4.43	No	No	0	9	8
28	R:R:V73	R:R:V88	4.81	No	No	0	8	7
29	R:R:F74	R:R:T75	2.59	No	No	0	6	7
30	R:R:L79	R:R:S76	9.01	No	No	0	9	8
31	R:R:F448	R:R:L79	7.31	Yes	No	0	8	9
32	R:R:A451	R:R:L79	3.15	No	No	0	8	9
33	R:R:P82	R:R:R160	2.88	No	Yes	0	7	7
34	R:R:N84	R:R:Q83	2.64	No	No	0	9	9
35	R:R:D145	R:R:Q83	10.44	Yes	No	6	9	9
36	R:R:Q83	R:R:R160	12.85	No	Yes	6	9	7
37	R:R:I165	R:R:L85	4.28	No	No	0	8	8
38	R:R:K166	R:R:L85	2.82	No	No	0	6	8
39	R:R:A141	R:R:F86	2.77	No	Yes	0	8	8
40	R:R:D145	R:R:F86	4.78	Yes	Yes	0	9	8
41	R:R:F86	R:R:I165	11.3	Yes	No	0	8	8
42	R:R:F86	R:R:I168	5.02	Yes	No	0	8	7
43	R:R:F86	R:R:I169	2.51	Yes	No	0	8	8
44	R:R:S89	R:R:S92	3.26	Yes	No	0	9	7
45	R:R:H138	R:R:S89	9.76	Yes	Yes	2	8	9
46	R:R:I169	R:R:S89	4.64	No	Yes	0	8	9
47	R:R:S89	R:R:W173	4.94	Yes	Yes	2	9	9
48	R:R:H138	R:R:L90	6.43	Yes	No	0	8	9
49	R:R:L90	R:R:N437	4.12	No	No	0	9	9
50	R:R:A93	R:R:S134	3.42	No	No	2	8	8
51	R:R:A93	R:R:H138	2.93	No	Yes	2	8	8
52	R:R:A93	R:R:W173	2.59	No	Yes	2	8	9
53	R:R:D94	R:R:S434	8.83	Yes	No	0	9	9
54	R:R:I95	R:R:L96	2.85	No	No	0	8	8
55	R:R:F131	R:R:L96	6.09	Yes	No	0	7	8
56	R:R:V101	R:R:V97	3.21	Yes	No	0	8	8
57	R:R:F131	R:R:V97	6.55	Yes	No	0	7	8
58	R:R:L100	R:R:L127	6.92	No	No	0	7	7
59	R:R:S105	R:R:V101	3.23	No	Yes	1	8	8
60	R:R:V101	R:R:Y124	3.79	Yes	Yes	1	8	7
61	R:R:D128	R:R:V101	10.22	No	Yes	1	8	8
62	R:R:V101	R:R:Y431	6.31	Yes	Yes	1	8	8
63	R:R:I102	R:R:P103	3.39	No	No	0	8	9
64	R:R:I102	R:R:Y431	3.63	No	Yes	0	8	8
65	R:R:F104	R:R:P103	2.89	No	No	0	7	9
66	R:R:F104	R:R:Y124	10.32	No	Yes	0	7	7
67	R:R:S105	R:R:Y124	2.54	No	Yes	1	8	7
68	R:R:S105	R:R:Y431	2.54	No	Yes	1	8	8
69	R:R:E200	R:R:Y113	11.22	No	No	0	3	5
70	R:R:F116	R:R:W114	13.03	No	Yes	0	7	8
71	R:R:G117	R:R:W114	2.81	No	Yes	0	7	8
72	R:R:C121	R:R:W114	10.45	No	Yes	10	9	8
73	R:R:P201	R:R:W114	12.16	No	Yes	0	3	8
74	R:R:C203	R:R:W114	3.92	No	Yes	10	9	8
75	R:R:A119	R:R:W120	2.59	No	No	0	5	6
76	R:R:I123	R:R:W120	3.52	No	No	0	6	6
77	R:R:C121	R:R:C203	7.28	No	No	10	9	9
78	R:R:E122	R:R:L184	13.25	No	No	0	7	7
79	R:R:L125	R:R:Y124	3.52	No	Yes	0	7	7
80	R:R:I205	R:R:L125	2.85	No	No	0	7	7
81	R:R:F131	R:R:L127	9.74	Yes	No	0	7	7
82	R:R:D128	R:R:Y431	3.45	No	Yes	1	8	8
83	L:L:?1	R:R:D128	17.72	Yes	No	1	0	8
84	L:L:?1	R:R:V129	10.94	Yes	No	0	0	8
85	R:R:F131	R:R:L130	4.87	Yes	No	0	7	7
86	R:R:L130	R:R:S176	3	No	No	0	7	8
87	R:R:L130	R:R:S180	9.01	No	No	0	7	8
88	R:R:C132	R:R:W402	2.61	No	Yes	0	7	9
89	L:L:?1	R:R:C132	11.66	Yes	No	0	0	7
90	R:R:S176	R:R:T133	3.2	No	No	0	8	8
91	R:R:S219	R:R:T133	3.2	No	No	0	8	8
92	R:R:S134	R:R:W173	6.18	No	Yes	2	8	9
93	R:R:S134	R:R:S176	3.26	No	No	0	8	8
94	R:R:I136	R:R:P223	3.39	No	No	0	9	9
95	R:R:F398	R:R:I136	2.51	No	No	0	9	9
96	R:R:I136	R:R:W402	5.87	No	Yes	0	9	9
97	R:R:V137	R:R:V172	3.21	No	No	0	7	8
98	R:R:H138	R:R:V172	9.69	Yes	No	0	8	8
99	R:R:H138	R:R:W173	10.58	Yes	Yes	2	8	9
100	R:R:L139	R:R:M227	2.83	Yes	Yes	0	8	9
101	R:R:F398	R:R:L139	4.87	No	Yes	0	9	8
102	R:R:L139	R:R:N437	4.12	Yes	No	9	8	9
103	R:R:L139	R:R:Y441	7.03	Yes	Yes	9	8	9
104	R:R:C140	R:R:M227	4.86	No	Yes	0	7	9
105	R:R:I142	R:R:R146	2.51	No	No	0	9	9
106	R:R:I142	R:R:Y441	4.84	No	Yes	0	9	9
107	R:R:M227	R:R:S143	6.13	Yes	No	0	9	9
108	R:R:S143	R:R:V230	3.23	No	Yes	3	9	8
109	R:R:S143	R:R:Y231	6.36	No	Yes	3	9	9
110	R:R:L144	R:R:W148	6.83	No	No	0	7	6
111	R:R:D145	R:R:Y156	4.6	Yes	Yes	6	9	9
112	R:R:D145	R:R:R160	10.72	Yes	Yes	6	9	7
113	R:R:T151	R:R:Y147	18.73	No	Yes	0	7	8
114	R:R:V230	R:R:Y147	7.57	Yes	Yes	3	8	8
115	R:R:R233	R:R:Y147	7.2	No	Yes	0	7	8
116	R:R:I234	R:R:Y147	3.63	No	Yes	3	9	8
117	R:R:W148	R:R:Y156	11.58	No	Yes	0	6	9
118	R:R:R160	R:R:Y156	8.23	Yes	Yes	6	7	9
119	R:R:I175	R:R:T171	3.04	No	No	0	7	5
120	R:R:I175	R:R:I179	2.94	No	No	0	7	8
121	R:R:F181	R:R:P182	7.22	No	No	0	6	8
122	R:R:P182	R:R:Y211	5.56	No	Yes	0	8	8
123	R:R:N206	R:R:P183	3.26	No	No	4	7	8
124	R:R:P183	R:R:Q208	6.32	No	Yes	4	8	6
125	R:R:N206	R:R:Q208	17.17	No	Yes	4	7	6
126	R:R:Q208	R:R:W210	8.76	Yes	No	4	6	5
127	R:R:Q208	R:R:Y211	3.38	Yes	Yes	4	6	8
128	R:R:K209	R:R:V414	4.55	No	No	0	5	5
129	R:R:W210	R:R:Y211	9.65	No	Yes	4	5	8
130	R:R:S215	R:R:Y211	5.09	No	Yes	0	9	8
131	R:R:V212	R:R:Y409	8.83	No	No	0	7	8
132	R:R:A413	R:R:V212	5.09	No	No	0	7	7
133	L:L:?1	R:R:S215	3.68	Yes	No	0	0	9
134	R:R:C216	R:R:F406	6.98	No	Yes	0	7	8
135	R:R:C216	R:R:Y409	4.03	No	No	0	7	8
136	R:R:C216	R:R:T410	5.07	No	No	0	7	7
137	R:R:F221	R:R:I217	6.28	No	No	0	7	6
138	R:R:F406	R:R:S219	2.64	Yes	No	0	8	8
139	R:R:F220	R:R:F221	5.36	Yes	No	0	9	7
140	R:R:C224	R:R:F220	9.78	No	Yes	0	7	9
141	R:R:F220	R:R:F403	4.29	Yes	No	0	9	7
142	R:R:F220	R:R:F406	21.43	Yes	Yes	0	9	8
143	R:R:F221	R:R:T410	2.59	No	No	0	7	7
144	R:R:C224	R:R:F398	5.59	No	No	0	7	9
145	R:R:I226	R:R:L225	4.28	No	No	0	8	5
146	R:R:I226	R:R:M227	2.92	No	Yes	0	8	9
147	R:R:I228	R:R:I395	2.94	No	No	0	6	7
148	R:R:L229	R:R:R233	4.86	No	No	0	5	7
149	R:R:V230	R:R:Y231	3.79	Yes	Yes	3	8	9
150	R:R:I234	R:R:V230	3.07	No	Yes	3	9	8
151	R:R:L391	R:R:Y231	11.72	No	Yes	0	8	9
152	R:R:V394	R:R:Y231	5.05	Yes	Yes	0	8	9
153	R:R:F387	R:R:Y235	5.16	Yes	No	7	8	8
154	R:R:T388	R:R:Y235	11.24	No	No	7	8	8
155	R:R:K239	R:R:Q236	8.14	No	No	0	8	6
156	R:R:I237	R:R:R240	3.76	No	No	0	7	7
157	R:R:A238	R:R:F387	4.16	No	Yes	0	8	8
158	R:R:R380	R:R:T242	5.17	No	No	0	5	5
159	R:R:R380	R:R:W377	6	No	No	0	5	5
160	R:R:K385	R:R:Q381	5.42	No	No	0	7	6
161	R:R:E384	R:R:K385	2.7	No	No	0	9	7
162	R:R:E384	R:R:F387	5.83	No	Yes	7	9	8
163	R:R:E384	R:R:T388	5.64	No	No	7	9	8
164	R:R:F387	R:R:T388	5.19	Yes	No	7	8	8
165	R:R:F389	R:R:V390	2.62	No	No	0	7	8
166	R:R:F444	R:R:V390	13.11	No	No	0	8	8
167	R:R:F444	R:R:V393	2.62	No	No	0	8	7
168	R:R:I440	R:R:V394	3.07	No	Yes	0	8	8
169	R:R:V394	R:R:Y441	2.52	Yes	Yes	0	8	9
170	R:R:L436	R:R:V397	5.96	No	No	0	7	8
171	R:R:C401	R:R:N433	9.45	No	No	0	8	9
172	R:R:F406	R:R:W402	7.02	Yes	Yes	0	8	9
173	R:R:G430	R:R:W402	8.44	No	Yes	0	8	9
174	R:R:N433	R:R:W402	10.17	No	Yes	0	9	9
175	R:R:F403	R:R:F407	5.36	No	No	0	7	7
176	R:R:F426	R:R:P404	7.22	Yes	No	0	7	9
177	R:R:F405	R:R:F423	9.65	Yes	No	0	8	6
178	R:R:F405	R:R:F426	4.29	Yes	Yes	0	8	7
179	R:R:F405	R:R:F427	8.57	Yes	No	1	8	7
180	L:L:?1	R:R:F405	13.91	Yes	Yes	1	0	8
181	R:R:F407	R:R:L411	8.53	No	No	0	7	7
182	R:R:F426	R:R:T408	7.78	Yes	No	0	7	7
183	L:L:?1	R:R:Y409	5.74	Yes	No	0	0	8
184	R:R:S417	R:R:T412	6.4	No	No	11	1	5
185	R:R:P419	R:R:T412	5.25	No	No	11	7	5
186	R:R:P419	R:R:S417	3.56	No	No	11	7	1
187	R:R:F426	R:R:L422	6.09	Yes	No	0	7	7
188	R:R:F425	R:R:K424	8.69	No	No	0	6	7
189	R:R:K424	R:R:W428	9.28	No	No	0	7	7
190	R:R:F427	R:R:Y431	9.28	No	Yes	1	7	8
191	L:L:?1	R:R:F427	24.85	Yes	No	1	0	7
192	L:L:?1	R:R:Y431	15.31	Yes	Yes	1	0	8
193	R:R:I440	R:R:L436	4.28	No	No	0	8	7
194	R:R:N437	R:R:Y441	6.98	No	Yes	9	9	9
195	R:R:T442	R:R:V439	3.17	Yes	No	0	9	7
196	R:R:F448	R:R:T442	6.49	Yes	Yes	5	8	9
197	R:R:F452	R:R:T442	6.49	Yes	Yes	5	8	9
198	R:R:F444	R:R:I443	12.56	No	No	0	8	7
199	R:R:D447	R:R:N445	12.12	No	No	0	8	9
200	R:R:F448	R:R:N445	7.25	Yes	No	0	8	9
201	R:R:D447	R:R:H446	5.04	No	No	0	8	6
202	R:R:F448	R:R:F452	6.43	Yes	Yes	5	8	8
203	R:R:C457	R:R:L456	3.17	No	No	0	6	8
204	R:R:F448	R:R:L87	2.44	Yes	No	0	8	8
205	R:R:L422	R:R:R420	2.43	No	No	0	7	4
206	R:R:N157	R:R:R160	2.41	No	Yes	0	7	7
207	R:R:K239	R:R:Y235	2.39	No	No	0	8	8
208	R:R:Q152	R:R:W148	2.19	No	No	0	7	6
209	R:R:F426	R:R:F429	2.14	Yes	No	0	7	8
210	R:R:R376	R:R:R378	2.13	No	No	0	7	6
211	R:R:R380	R:R:R383	2.13	No	No	0	5	8
212	R:R:F116	R:R:Y115	2.06	No	No	0	7	5
213	R:R:R164	R:R:Y156	2.06	No	Yes	0	8	9
214	R:R:A81	R:R:P82	1.87	No	No	0	8	7
215	R:R:A222	R:R:P223	1.87	No	No	0	6	9
216	R:R:G396	R:R:V399	1.84	No	No	0	7	7
217	R:R:G415	R:R:V414	1.84	No	No	0	3	5
218	R:R:P419	R:R:V418	1.77	No	No	0	7	6
219	R:R:G218	R:R:I217	1.76	No	No	0	6	6
220	R:R:G396	R:R:I395	1.76	No	No	0	7	7
221	R:R:G56	R:R:M59	1.75	No	No	0	6	7
222	R:R:P162	R:R:T161	1.75	No	No	0	6	8
223	R:R:G65	R:R:L68	1.71	No	No	0	9	8
224	R:R:A177	R:R:S180	1.71	No	No	0	7	8
225	R:R:C401	R:R:V400	1.71	No	No	0	8	5
226	R:R:C416	R:R:V418	1.71	No	No	0	8	6
227	R:R:A98	R:R:V63	1.7	No	No	0	9	7
228	R:R:A91	R:R:V69	1.7	No	Yes	0	9	9
229	R:R:G379	R:R:N382	1.7	No	No	0	4	5
230	R:R:A98	R:R:T62	1.68	No	Yes	0	9	8
231	R:R:S44	R:R:V47	1.62	No	No	0	7	5
232	R:R:A153	R:R:I154	1.62	No	No	0	9	7
233	R:R:V63	R:R:V67	1.6	No	No	0	7	6
234	R:R:V174	R:R:V178	1.6	No	No	0	5	6
235	R:R:V393	R:R:V394	1.6	No	Yes	0	7	8
236	R:R:V393	R:R:V397	1.6	No	No	0	7	8
237	R:R:T48	R:R:V110	1.59	No	No	0	4	7
238	R:R:C432	R:R:L58	1.59	No	No	0	7	7
239	R:R:C121	R:R:L125	1.59	No	No	0	9	7
240	R:R:A55	R:R:L106	1.58	No	No	0	5	8
241	R:R:E122	R:R:P183	1.57	No	No	0	7	8
242	R:R:E200	R:R:P201	1.57	No	No	0	3	3
243	R:R:I213	R:R:S214	1.55	No	No	0	7	7
244	R:R:I170	R:R:V174	1.54	No	No	0	5	5
245	R:R:I228	R:R:V232	1.54	No	No	0	6	4
246	R:R:K80	R:R:S76	1.53	No	No	0	7	8
247	R:R:M111	R:R:V110	1.52	No	No	0	7	7
248	R:R:I179	R:R:T133	1.52	No	No	0	8	8
249	R:R:I150	R:R:T151	1.52	No	No	0	8	7
250	R:R:I237	R:R:T151	1.52	No	No	0	7	7
251	R:R:F64	R:R:G65	1.51	No	No	0	5	9
252	R:R:G379	R:R:R378	1.5	No	No	0	4	6
253	R:R:L54	R:R:T50	1.47	No	No	0	5	3
254	R:R:D94	R:R:S135	1.47	Yes	No	0	9	9
255	R:R:L96	R:R:T99	1.47	No	No	0	8	6
256	R:R:L100	R:R:T99	1.47	No	No	0	7	6
257	R:R:L411	R:R:T412	1.47	No	No	0	7	5
258	R:R:I395	R:R:M227	1.46	No	Yes	0	7	9
259	R:R:G112	R:R:Y113	1.45	No	No	0	6	5
260	R:R:I455	R:R:K454	1.45	No	No	0	8	7
261	R:R:I455	R:R:L68	1.43	No	No	0	8	8
262	R:R:Q236	R:R:V232	1.43	No	No	0	6	4
263	R:R:L60	R:R:M59	1.41	No	No	0	6	7
264	R:R:E122	R:R:I123	1.37	No	No	0	7	6
265	R:R:D207	R:R:N206	1.35	No	No	0	5	7
266	R:R:E155	R:R:L158	1.33	No	No	0	6	6
267	R:R:R160	R:R:S149	1.32	Yes	No	0	7	9
268	R:R:E109	R:R:N108	1.31	No	No	0	7	8
269	R:R:R163	R:R:T161	1.29	No	No	0	5	8
270	R:R:R164	R:R:T161	1.29	No	No	0	8	8
271	R:R:R241	R:R:T242	1.29	No	No	0	8	5
272	R:R:K159	R:R:R164	1.24	No	No	0	6	8
273	R:R:F425	R:R:L422	1.22	No	No	0	6	7
274	R:R:N382	R:R:R383	1.21	No	No	0	5	8
275	R:R:M111	R:R:Y115	1.2	No	No	0	7	5
276	R:R:D447	R:R:R450	1.19	No	No	0	8	6
277	R:R:N108	R:R:W114	1.13	No	Yes	0	8	8
278	R:R:H446	R:R:R449	1.13	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T62	3.8025	4	8	8
2	R:R:N66	7.5075	4	8	9
3	R:R:V69	3.1825	4	5	9
4	R:R:F86	5.276	5	0	8
5	R:R:S89	5.65	4	2	9
6	R:R:D94	7.025	4	8	9
7	R:R:V101	5.352	5	1	8
8	R:R:W114	7.25	6	10	8
9	R:R:Y124	5.0425	4	1	7
10	R:R:F131	6.8125	4	0	7
11	R:R:H138	7.878	5	2	8
12	R:R:L139	4.7125	4	9	8
13	R:R:D145	7.635	4	6	9
14	R:R:Y147	9.2825	4	3	8
15	R:R:Y156	6.6175	4	6	9
16	R:R:R160	6.40167	6	6	7
17	R:R:W173	6.0725	4	2	9
18	R:R:Q208	8.9075	4	4	6
19	R:R:Y211	5.92	4	4	8
20	R:R:F220	10.215	4	0	9
21	R:R:M227	3.64	5	0	9
22	R:R:V230	4.415	4	3	8
23	R:R:Y231	6.73	4	3	9
24	R:R:F387	5.085	4	7	8
25	R:R:V394	3.06	4	0	8
26	R:R:W402	6.822	5	0	9
27	R:R:F405	9.105	4	1	8
28	R:R:F406	9.5175	4	0	8
29	R:R:F426	5.504	5	0	7
30	R:R:Y431	6.75333	6	1	8
31	R:R:Y441	5.3425	4	9	9
32	R:R:T442	4.83	4	5	9
33	R:R:F448	5.42333	6	5	8
34	R:R:F452	5.926	5	5	8
35	L:L:?1	12.9762	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L54	R:R:T50	17.0155	1.47	No	No	0	5	3
2	R:R:L51	R:R:L54	20.3888	4.15	No	No	0	6	5
3	R:R:K424	R:R:L51	23.4535	7.05	No	No	0	7	6
4	R:R:K424	R:R:W428	13.3337	9.28	No	No	0	7	7
5	R:R:F425	R:R:K424	39.8416	8.69	No	No	0	6	7
6	R:R:F425	R:R:L422	43.1429	1.22	No	No	0	6	7
7	R:R:F426	R:R:L422	49.7146	6.09	Yes	No	0	7	7
8	R:R:F405	R:R:F426	62.7346	4.29	Yes	Yes	0	8	7
9	R:R:F405	R:R:F427	13.6885	8.57	Yes	No	1	8	7
10	R:R:F427	R:R:Y431	14.2027	9.28	No	Yes	1	7	8
11	R:R:V101	R:R:Y431	44.5879	6.31	Yes	Yes	1	8	8
12	R:R:V101	R:R:V97	56.7131	3.21	Yes	No	0	8	8
13	R:R:F131	R:R:V97	55.8389	6.55	Yes	No	0	7	8
14	R:R:F131	R:R:L96	28.5288	6.09	Yes	No	0	7	8
15	R:R:I95	R:R:L96	24.9293	2.85	No	No	0	8	8
16	R:R:I95	R:R:N66	23.073	5.66	No	Yes	0	8	9
17	R:R:N66	R:R:T62	13.5291	4.39	Yes	Yes	8	9	8
18	L:L:?1	R:R:F405	55.2682	13.91	Yes	Yes	1	0	8
19	L:L:?1	R:R:Y431	48.0588	15.31	Yes	Yes	1	0	8
20	L:L:?1	R:R:D128	30.8479	17.72	Yes	No	1	0	8
21	R:R:D128	R:R:V101	30.7297	10.22	No	Yes	1	8	8
22	R:R:F452	R:R:V69	17.1492	5.24	Yes	Yes	5	8	9
23	R:R:A91	R:R:V69	46.871	1.7	No	Yes	0	9	9
24	R:R:A91	R:R:I70	48.8919	3.25	No	No	0	9	8
25	R:R:I70	R:R:V88	54.8928	4.61	No	No	0	8	7
26	R:R:V73	R:R:V88	56.8725	4.81	No	No	0	8	7
27	R:R:N84	R:R:V73	58.842	4.43	No	No	0	9	8
28	R:R:N84	R:R:Q83	60.8012	2.64	No	No	0	9	9
29	R:R:D145	R:R:Q83	60.5903	10.44	Yes	No	6	9	9
30	R:R:D145	R:R:F86	88.0239	4.78	Yes	Yes	0	9	8
31	R:R:F86	R:R:I169	98.3236	2.51	Yes	No	0	8	8
32	R:R:I169	R:R:S89	100	4.64	No	Yes	0	8	9
33	R:R:H138	R:R:S89	33.3573	9.76	Yes	Yes	2	8	9
34	R:R:H138	R:R:L90	49.2621	6.43	Yes	No	0	8	9
35	R:R:L90	R:R:N437	49.1593	4.12	No	No	0	9	9
36	R:R:L139	R:R:N437	36.2627	4.12	Yes	No	9	8	9
37	R:R:F398	R:R:L139	56.4612	4.87	No	Yes	0	9	8
38	R:R:F398	R:R:I136	47.7194	2.51	No	No	0	9	9
39	R:R:I136	R:R:W402	48.8919	5.87	No	Yes	0	9	9
40	R:R:C132	R:R:W402	65.352	2.61	No	Yes	0	7	9
41	L:L:?1	R:R:C132	65.1257	11.66	Yes	No	0	0	7
42	R:R:S89	R:R:W173	69.9594	4.94	Yes	Yes	2	9	9
43	R:R:S134	R:R:W173	78.9736	6.18	No	Yes	2	8	9
44	R:R:S134	R:R:S176	88.9392	3.26	No	No	0	8	8
45	R:R:S176	R:R:T133	35.7587	3.2	No	No	0	8	8
46	R:R:S219	R:R:T133	37.1985	3.2	No	No	0	8	8
47	R:R:F406	R:R:S219	38.371	2.64	Yes	No	0	8	8
48	R:R:F406	R:R:W402	24.9756	7.02	Yes	Yes	0	8	9
49	R:R:L130	R:R:S176	61.9633	3	No	No	0	7	8
50	R:R:F131	R:R:L130	61.0223	4.87	Yes	No	0	7	7
51	R:R:C216	R:R:F406	23.0884	6.98	No	Yes	0	7	8
52	R:R:C216	R:R:Y409	24.7185	4.03	No	No	0	7	8
53	L:L:?1	R:R:Y409	24.811	5.74	Yes	No	0	0	8
54	R:R:F452	R:R:L68	13.3182	7.31	Yes	No	0	8	8
55	R:R:F448	R:R:V69	23.3918	2.62	Yes	Yes	5	8	9
56	R:R:S105	R:R:Y431	15.7762	2.54	No	Yes	1	8	8
57	R:R:V101	R:R:Y124	37.2191	3.79	Yes	Yes	1	8	7
58	R:R:S105	R:R:Y124	15.1386	2.54	No	Yes	1	8	7
59	R:R:P201	R:R:W114	11.4516	12.16	No	Yes	0	3	8
60	R:R:C121	R:R:W114	36.5609	10.45	No	Yes	10	9	8
61	R:R:C121	R:R:L125	42.1093	1.59	No	No	0	9	7
62	R:R:L125	R:R:Y124	47.2875	3.52	No	Yes	0	7	7
63	R:R:F116	R:R:W114	14.2901	13.03	No	Yes	0	7	8
64	R:R:E122	R:R:P183	13.5239	1.57	No	No	0	7	8
65	R:R:P183	R:R:Q208	16.1876	6.32	No	Yes	4	8	6
66	R:R:Q208	R:R:Y211	24.3019	3.38	Yes	Yes	4	6	8
67	R:R:S215	R:R:Y211	35.0028	5.09	No	Yes	0	9	8
68	L:L:?1	R:R:S215	37.6408	3.68	Yes	No	0	0	9
69	R:R:L139	R:R:M227	44.3462	2.83	Yes	Yes	0	8	9
70	R:R:L139	R:R:Y441	12.3515	7.03	Yes	Yes	9	8	9
71	R:R:M227	R:R:S143	17.2263	6.13	Yes	No	0	9	9
72	R:R:S143	R:R:V230	13.0971	3.23	No	Yes	3	9	8
73	R:R:V394	R:R:Y441	21.52	2.52	Yes	Yes	0	8	9
74	R:R:D145	R:R:Y156	19.0055	4.6	Yes	Yes	6	9	9
75	R:R:V230	R:R:Y147	14.5267	7.57	Yes	Yes	3	8	8
76	R:R:F220	R:R:F406	20.0288	21.43	Yes	Yes	0	9	8
77	R:R:C224	R:R:F220	11.1585	9.78	No	Yes	0	7	9
78	R:R:C224	R:R:F398	10.9426	5.59	No	No	0	7	9
79	R:R:F220	R:R:F403	17.7662	4.29	Yes	No	0	9	7
80	R:R:I228	R:R:I395	21.4686	2.94	No	No	0	6	7
81	R:R:I395	R:R:M227	25.8806	1.46	No	Yes	0	7	9
82	R:R:K239	R:R:Y235	15.442	2.39	No	No	0	8	8
83	R:R:K239	R:R:Q236	16.9641	8.14	No	No	0	8	6
84	R:R:Q236	R:R:V232	18.4759	1.43	No	No	0	6	4
85	R:R:I228	R:R:V232	19.9774	1.54	No	No	0	6	4
86	R:R:V393	R:R:V394	10.2021	1.6	No	Yes	0	7	8
87	R:R:F403	R:R:F407	15.5808	5.36	No	No	0	7	7
88	R:R:F407	R:R:L411	13.3851	8.53	No	No	0	7	7
89	R:R:L411	R:R:T412	11.1791	1.47	No	No	0	7	5
90	R:R:F448	R:R:N445	11.1277	7.25	Yes	No	0	8	9
91	R:R:F116	R:R:Y115	11.4516	2.06	No	No	0	7	5
92	R:R:R164	R:R:Y156	11.6368	2.06	No	Yes	0	8	9
93	R:R:N437	R:R:Y441	13.3234	6.98	No	Yes	9	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S105	R:R:V101	3.23	1	No	Yes	8	8	2	2
R:R:D128	R:R:V101	10.22	1	No	Yes	8	8	1	2
R:R:V101	R:R:Y431	6.31	1	Yes	Yes	8	8	2	1
R:R:I102	R:R:Y431	3.63	0	No	Yes	8	8	2	1
R:R:S105	R:R:Y431	2.54	1	No	Yes	8	8	2	1
R:R:D128	R:R:Y431	3.45	1	No	Yes	8	8	1	1
L:L:?1	R:R:D128	17.72	1	Yes	No	0	8	0	1
L:L:?1	R:R:V129	10.94	1	Yes	No	0	8	0	1
R:R:C132	R:R:W402	2.61	0	No	Yes	7	9	1	2
L:L:?1	R:R:C132	11.66	1	Yes	No	0	7	0	1
R:R:S215	R:R:Y211	5.09	0	No	Yes	9	8	1	2
R:R:V212	R:R:Y409	8.83	0	No	No	7	8	2	1
L:L:?1	R:R:S215	3.68	1	Yes	No	0	9	0	1
R:R:C216	R:R:Y409	4.03	0	No	No	7	8	2	1
R:R:F405	R:R:F423	9.65	1	Yes	No	8	6	1	2
R:R:F405	R:R:F426	4.29	1	Yes	Yes	8	7	1	2
R:R:F405	R:R:F427	8.57	1	Yes	No	8	7	1	1
L:L:?1	R:R:F405	13.91	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	5.74	1	Yes	No	0	8	0	1
R:R:F427	R:R:Y431	9.28	1	No	Yes	7	8	1	1
L:L:?1	R:R:F427	24.85	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y431	15.31	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EJA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	255
Number of Links	278
Number of Hubs	35
Number of Links mediated by Hubs	129
Number of Communities	11
Number of Nodes involved in Communities	47
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	49829
Length Of Smallest Path	3
Average Path Length	15.845
Length of Longest Path	35
Minimum Path Strength	1.22
Average Path Strength	5.47556
Maximum Path Strength	21.285
Minimum Path Correlation	0.7
Average Path Correlation	0.930158
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	45.7044
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.4213
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	dexemedetomidine
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>7EJA_nogp_Chain_R Y S L Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P P L E P R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R S R W R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS79948	-	-	2.7	2019-12-04	doi.org/10.1038/nature06325
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	doi.org/10.1038/nature06325
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Norepinephrine	-		3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	doi.org/10.1126/science.abn7065
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9IQR	A	Amine	Adrenergic	α_2a	Homo sapiens	-	Muscarinic toxin 3	-	3.4	2025-07-23	To be published
	9PLN	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-	-	2.8	2025-08-20	To be published
	9PLO	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-	Go/β1/γ2	2.74	2025-08-20	To be published
	9PLO (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-		2.74	2025-08-20	To be published
	9PQD	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 176491927	-	-	3.29	2025-08-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EJA_nogp.zip

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