psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q46	R:R:V47	4.3	No	No	0	4	5
2	R:R:A55	R:R:L106	4.73	No	Yes	0	5	8
3	R:R:L57	R:R:L61	2.77	No	No	0	5	5
4	R:R:N66	R:R:T62	4.39	Yes	Yes	5	9	8
5	R:R:D94	R:R:T62	4.34	Yes	Yes	5	9	8
6	R:R:S435	R:R:T62	9.59	No	Yes	0	8	8
7	R:R:F64	R:R:L68	2.44	No	Yes	0	5	8
8	R:R:D94	R:R:N66	13.46	Yes	Yes	5	9	9
9	R:R:I95	R:R:N66	2.83	No	Yes	0	8	9
10	R:R:I95	R:R:V67	3.07	No	No	0	8	6
11	R:R:F452	R:R:L68	12.18	No	Yes	0	8	8
12	R:R:A91	R:R:I70	3.25	No	No	0	9	8
13	R:R:I455	R:R:I71	2.94	No	No	0	8	7
14	R:R:A72	R:R:F452	2.77	No	No	0	9	8
15	R:R:N84	R:R:V73	2.96	Yes	No	0	9	8
16	R:R:V73	R:R:V88	4.81	No	No	0	8	7
17	R:R:L79	R:R:S76	6.01	Yes	No	0	9	8
18	R:R:K80	R:R:R77	2.48	No	No	0	7	8
19	R:R:L79	R:R:N84	4.12	Yes	Yes	6	9	9
20	R:R:F448	R:R:L79	15.83	Yes	Yes	6	8	9
21	R:R:A81	R:R:N84	4.69	No	Yes	0	8	9
22	R:R:P82	R:R:R160	4.32	No	Yes	0	7	7
23	R:R:D145	R:R:Q83	2.61	No	No	4	9	9
24	R:R:Q83	R:R:R160	10.51	No	Yes	4	9	7
25	R:R:F448	R:R:N84	3.62	Yes	Yes	6	8	9
26	R:R:F86	R:R:I142	3.77	Yes	No	0	8	9
27	R:R:F86	R:R:I165	11.3	Yes	No	0	8	8
28	R:R:F86	R:R:I168	6.28	Yes	No	0	8	7
29	R:R:F86	R:R:I169	2.51	Yes	No	0	8	8
30	R:R:L87	R:R:Y441	2.34	No	Yes	0	8	9
31	R:R:F448	R:R:L87	2.44	Yes	No	0	8	8
32	R:R:S89	R:R:S92	3.26	Yes	No	0	9	7
33	R:R:H138	R:R:S89	11.16	Yes	Yes	0	8	9
34	R:R:I169	R:R:S89	4.64	No	Yes	7	8	9
35	R:R:S89	R:R:W173	3.71	Yes	Yes	7	9	9
36	R:R:L90	R:R:S135	3	No	No	0	9	9
37	R:R:H138	R:R:L90	3.86	Yes	No	0	8	9
38	R:R:L90	R:R:N437	6.87	No	Yes	0	9	9
39	R:R:A93	R:R:W173	2.59	No	Yes	0	8	9
40	R:R:D94	R:R:V97	2.92	Yes	No	0	9	8
41	R:R:D94	R:R:S434	10.31	Yes	No	0	9	9
42	R:R:I95	R:R:L96	2.85	No	No	0	8	8
43	R:R:L100	R:R:L96	5.54	No	No	8	7	8
44	R:R:F131	R:R:L96	13.4	No	No	8	7	8
45	R:R:V101	R:R:V97	3.21	Yes	No	0	8	8
46	R:R:F131	R:R:V97	11.8	No	No	0	7	8
47	R:R:A98	R:R:I102	3.25	No	Yes	0	9	8
48	R:R:L100	R:R:T99	2.95	No	No	0	7	6
49	R:R:F131	R:R:L100	2.44	No	No	8	7	7
50	R:R:D128	R:R:V101	8.76	No	Yes	1	8	8
51	R:R:V101	R:R:Y431	6.31	Yes	Yes	1	8	8
52	R:R:I102	R:R:P103	3.39	Yes	No	0	8	9
53	R:R:I102	R:R:S105	3.1	Yes	No	1	8	8
54	R:R:I102	R:R:W428	2.35	Yes	Yes	1	8	7
55	R:R:F104	R:R:W114	6.01	Yes	Yes	2	7	8
56	R:R:F104	R:R:F116	3.22	Yes	Yes	2	7	7
57	R:R:F104	R:R:W120	6.01	Yes	Yes	2	7	6
58	R:R:F104	R:R:Y124	6.19	Yes	No	2	7	7
59	R:R:S105	R:R:W428	6.18	No	Yes	1	8	7
60	R:R:N108	R:R:W114	3.39	No	Yes	0	8	8
61	R:R:E109	R:R:K424	20.25	No	No	0	7	7
62	R:R:M111	R:R:V110	3.04	No	No	0	7	7
63	R:R:M111	R:R:Y113	2.39	No	No	0	7	5
64	R:R:R202	R:R:Y113	3.09	No	No	0	5	5
65	R:R:F116	R:R:W114	13.03	Yes	Yes	2	7	8
66	R:R:C121	R:R:W114	5.22	No	Yes	2	9	8
67	R:R:C203	R:R:W114	9.14	Yes	Yes	2	9	8
68	R:R:F116	R:R:W120	12.03	Yes	Yes	2	7	6
69	R:R:C121	R:R:C203	7.28	No	Yes	2	9	9
70	R:R:L125	R:R:Y124	3.52	No	No	2	7	7
71	R:R:C203	R:R:Y124	2.69	Yes	No	2	9	7
72	R:R:C203	R:R:L125	3.17	Yes	No	2	9	7
73	R:R:D128	R:R:Y431	5.75	No	Yes	1	8	8
74	L:L:?1	R:R:D128	10.07	Yes	No	1	0	8
75	R:R:S180	R:R:V129	8.08	No	No	0	8	8
76	L:L:?1	R:R:V129	12.44	Yes	No	0	0	8
77	R:R:L130	R:R:S180	9.01	No	No	0	7	8
78	R:R:C132	R:R:W402	3.92	No	Yes	0	7	9
79	L:L:?1	R:R:C132	11.78	Yes	No	0	0	7
80	R:R:T133	R:R:V137	3.17	No	No	9	8	7
81	R:R:S176	R:R:T133	3.2	Yes	No	9	8	8
82	R:R:S219	R:R:T133	4.8	No	No	0	8	8
83	R:R:H138	R:R:S134	2.79	Yes	No	0	8	8
84	R:R:S134	R:R:W173	7.41	No	Yes	0	8	9
85	R:R:S134	R:R:S176	4.89	No	Yes	0	8	8
86	R:R:F220	R:R:I136	5.02	Yes	Yes	3	9	9
87	R:R:F398	R:R:I136	2.51	Yes	Yes	3	9	9
88	R:R:I136	R:R:W402	17.62	Yes	Yes	3	9	9
89	R:R:F406	R:R:I136	2.51	Yes	Yes	3	8	9
90	R:R:V137	R:R:V172	3.21	No	No	0	7	8
91	R:R:S176	R:R:V137	4.85	Yes	No	9	8	7
92	R:R:H138	R:R:V172	4.15	Yes	No	0	8	8
93	R:R:F398	R:R:L139	4.87	Yes	No	0	9	8
94	R:R:L139	R:R:N437	4.12	No	Yes	0	8	9
95	R:R:L139	R:R:Y441	9.38	No	Yes	0	8	9
96	R:R:C140	R:R:P223	7.53	No	No	0	7	9
97	R:R:C140	R:R:I226	3.27	No	No	0	7	8
98	R:R:I142	R:R:R146	3.76	No	No	0	9	9
99	R:R:M227	R:R:S143	9.2	No	No	0	9	9
100	R:R:S143	R:R:V230	3.23	No	Yes	10	9	8
101	R:R:S143	R:R:Y231	11.45	No	Yes	10	9	9
102	R:R:L144	R:R:W148	4.56	No	No	0	7	6
103	R:R:D145	R:R:Y156	6.9	No	Yes	4	9	9
104	R:R:D145	R:R:R160	2.38	No	Yes	4	9	7
105	R:R:R146	R:R:Y231	5.14	No	Yes	0	9	9
106	R:R:T151	R:R:Y147	14.98	No	Yes	0	7	8
107	R:R:V230	R:R:Y147	3.79	Yes	Yes	0	8	8
108	R:R:R233	R:R:Y147	8.23	Yes	Yes	0	7	8
109	R:R:I234	R:R:Y147	2.42	No	Yes	0	9	8
110	R:R:Q152	R:R:W148	3.29	No	No	0	7	6
111	R:R:W148	R:R:Y156	6.75	No	Yes	0	6	9
112	R:R:S149	R:R:Y156	2.54	No	Yes	4	9	9
113	R:R:R160	R:R:S149	2.64	Yes	No	4	7	9
114	R:R:I150	R:R:I234	5.89	No	No	0	8	9
115	R:R:Q152	R:R:T151	2.83	No	No	0	7	7
116	R:R:E155	R:R:K159	5.4	No	No	0	6	6
117	R:R:R160	R:R:Y156	9.26	Yes	Yes	4	7	9
118	R:R:R164	R:R:Y156	3.09	No	Yes	0	8	9
119	R:R:K159	R:R:R164	2.48	No	No	0	6	8
120	R:R:I168	R:R:T171	3.04	No	No	0	7	5
121	R:R:I169	R:R:W173	2.35	No	Yes	7	8	9
122	R:R:I175	R:R:V178	3.07	No	No	0	7	6
123	R:R:F181	R:R:P182	21.67	No	No	0	6	8
124	R:R:L184	R:R:P183	3.28	No	No	0	7	8
125	R:R:P183	R:R:Y211	4.17	No	No	0	8	8
126	R:R:E204	R:R:R202	5.82	No	No	0	4	5
127	R:R:I205	R:R:Y409	2.42	No	Yes	0	7	8
128	R:R:N206	R:R:Q208	3.96	No	No	0	7	6
129	R:R:Q208	R:R:W210	3.29	No	No	0	6	5
130	R:R:K209	R:R:V414	6.07	No	No	0	5	5
131	R:R:V212	R:R:Y211	2.52	No	No	0	7	8
132	R:R:V212	R:R:Y409	10.09	No	Yes	0	7	8
133	L:L:?1	R:R:S215	4.18	Yes	No	0	0	9
134	R:R:C216	R:R:F221	2.79	Yes	No	0	7	7
135	R:R:C216	R:R:F406	8.38	Yes	Yes	0	7	8
136	R:R:C216	R:R:Y409	2.69	Yes	Yes	0	7	8
137	R:R:C216	R:R:T410	3.38	Yes	No	0	7	7
138	R:R:G218	R:R:I217	3.53	No	No	0	6	6
139	R:R:F406	R:R:S219	5.28	Yes	No	0	8	8
140	L:L:?1	R:R:S219	5.57	Yes	No	0	0	8
141	R:R:F220	R:R:F221	11.79	Yes	No	0	9	7
142	R:R:C224	R:R:F220	8.38	No	Yes	3	7	9
143	R:R:F220	R:R:F398	3.22	Yes	Yes	3	9	9
144	R:R:F220	R:R:W402	5.01	Yes	Yes	3	9	9
145	R:R:F220	R:R:F403	3.22	Yes	No	0	9	7
146	R:R:F220	R:R:F406	24.65	Yes	Yes	3	9	8
147	R:R:A222	R:R:P223	3.74	No	No	0	6	9
148	R:R:C224	R:R:F398	4.19	No	Yes	3	7	9
149	R:R:L225	R:R:L229	2.77	No	No	0	5	5
150	R:R:F398	R:R:M227	3.73	Yes	No	0	9	9
151	R:R:I228	R:R:I395	2.94	No	No	0	6	7
152	R:R:V230	R:R:Y231	5.05	Yes	Yes	10	8	9
153	R:R:L391	R:R:Y231	8.21	No	Yes	0	8	9
154	R:R:Q236	R:R:R233	9.35	No	Yes	0	6	7
155	R:R:I237	R:R:R233	6.26	No	Yes	0	7	7
156	R:R:K239	R:R:Y235	9.55	No	Yes	0	8	8
157	R:R:T388	R:R:Y235	7.49	No	Yes	0	8	8
158	R:R:L391	R:R:Y235	3.52	No	Yes	0	8	8
159	R:R:A238	R:R:F387	4.16	No	No	0	8	8
160	R:R:R380	R:R:T242	2.59	No	No	0	5	5
161	R:R:R380	R:R:R383	3.2	No	No	0	5	8
162	R:R:E384	R:R:F387	10.49	No	No	0	9	8
163	R:R:F389	R:R:V393	6.55	No	No	0	7	7
164	R:R:F444	R:R:V390	14.42	No	No	0	8	8
165	R:R:V394	R:R:Y441	3.79	No	Yes	0	8	9
166	R:R:I440	R:R:V397	6.14	No	No	0	8	8
167	R:R:F398	R:R:V399	2.62	Yes	No	0	9	7
168	R:R:F403	R:R:V399	3.93	No	No	0	7	7
169	R:R:C401	R:R:N433	6.3	No	No	0	8	9
170	R:R:F406	R:R:W402	8.02	Yes	Yes	3	8	9
171	R:R:G430	R:R:W402	8.44	No	Yes	0	8	9
172	R:R:N433	R:R:W402	5.65	No	Yes	0	9	9
173	R:R:F403	R:R:P404	2.89	No	No	0	7	9
174	R:R:F426	R:R:P404	11.56	Yes	No	0	7	9
175	R:R:F405	R:R:Y409	6.19	Yes	Yes	1	8	8
176	R:R:F405	R:R:F426	3.22	Yes	Yes	0	8	7
177	R:R:F405	R:R:F427	7.5	Yes	No	1	8	7
178	L:L:?1	R:R:F405	3.39	Yes	Yes	1	0	8
179	R:R:P419	R:R:T408	3.5	No	No	11	7	7
180	R:R:F423	R:R:T408	5.19	No	No	11	6	7
181	R:R:F426	R:R:T408	6.49	Yes	No	0	7	7
182	L:L:?1	R:R:Y409	4.35	Yes	Yes	1	0	8
183	R:R:L411	R:R:S417	3	No	No	0	7	1
184	R:R:R420	R:R:V418	2.62	No	No	0	4	6
185	R:R:F423	R:R:P419	2.89	No	No	11	6	7
186	R:R:L422	R:R:R420	2.43	No	No	0	7	4
187	R:R:F425	R:R:L422	6.09	No	No	0	6	7
188	R:R:F426	R:R:L422	4.87	Yes	No	0	7	7
189	R:R:K424	R:R:W428	4.64	No	Yes	0	7	7
190	L:L:?1	R:R:F427	3.39	Yes	No	1	0	7
191	L:L:?1	R:R:Y431	4.35	Yes	Yes	1	0	8
192	R:R:N433	R:R:N437	2.72	No	Yes	0	9	9
193	R:R:L436	R:R:V439	2.98	No	No	0	7	7
194	R:R:I440	R:R:N437	2.83	No	Yes	0	8	9
195	R:R:I443	R:R:V439	4.61	No	No	0	7	7
196	R:R:I440	R:R:Y441	12.09	No	Yes	0	8	9
197	R:R:F448	R:R:T442	10.38	Yes	No	0	8	9
198	R:R:F452	R:R:T442	7.78	No	No	0	8	9
199	R:R:F444	R:R:I443	6.28	No	No	0	8	7
200	R:R:F448	R:R:N445	6.04	Yes	No	0	8	9
201	R:R:D447	R:R:H446	3.78	No	No	0	8	6
202	R:R:H446	R:R:R449	5.64	No	No	0	6	9
203	R:R:L106	R:R:W428	2.28	Yes	Yes	0	8	7
204	R:R:H446	R:R:R450	2.26	No	No	0	6	6
205	R:R:F389	R:R:R386	2.14	No	No	0	7	9
206	R:R:F387	R:R:Y235	2.06	No	Yes	0	8	8
207	R:R:G65	R:R:P438	2.03	No	No	0	9	9
208	R:R:A55	R:R:G56	1.95	No	No	0	5	6
209	R:R:A222	R:R:G218	1.95	No	No	0	6	6
210	R:R:W428	R:R:Y431	1.93	Yes	Yes	1	7	8
211	R:R:G396	R:R:V400	1.84	No	No	0	7	5
212	R:R:A451	R:R:A72	1.79	No	No	0	8	9
213	R:R:P438	R:R:V69	1.77	No	No	0	9	9
214	R:R:G396	R:R:I395	1.76	No	No	0	7	7
215	R:R:G56	R:R:M59	1.75	No	No	0	6	7
216	R:R:G112	R:R:M111	1.75	No	No	0	6	7
217	R:R:P162	R:R:T161	1.75	No	No	0	6	8
218	R:R:P419	R:R:T412	1.75	No	No	0	7	5
219	R:R:G65	R:R:L68	1.71	No	Yes	0	9	8
220	R:R:A126	R:R:V129	1.7	No	No	0	8	8
221	R:R:A413	R:R:K209	1.61	No	No	0	7	5
222	R:R:V63	R:R:V67	1.6	No	No	0	7	6
223	R:R:V390	R:R:V394	1.6	No	No	0	8	8
224	R:R:V393	R:R:V397	1.6	No	No	0	7	8
225	R:R:T50	R:R:V47	1.59	No	No	0	3	5
226	R:R:A177	R:R:L130	1.58	No	No	0	7	7
227	R:R:A91	R:R:N66	1.56	No	Yes	0	9	9
228	R:R:I175	R:R:S176	1.55	No	Yes	0	7	8
229	R:R:I179	R:R:S215	1.55	No	No	0	8	9
230	R:R:I213	R:R:V212	1.54	No	No	0	7	7
231	R:R:I226	R:R:V230	1.54	No	Yes	0	8	8
232	R:R:F116	R:R:G117	1.51	Yes	No	0	7	7
233	R:R:F429	R:R:G430	1.51	No	No	0	8	8
234	R:R:L61	R:R:S435	1.5	No	No	0	5	8
235	R:R:L106	R:R:V52	1.49	Yes	No	0	8	6
236	R:R:L127	R:R:V101	1.49	No	Yes	0	7	8
237	R:R:L49	R:R:T48	1.47	No	No	0	5	4
238	R:R:L58	R:R:T62	1.47	No	Yes	0	7	8
239	R:R:I395	R:R:M227	1.46	No	No	0	7	9
240	R:R:I455	R:R:L68	1.43	No	Yes	0	8	8
241	R:R:I165	R:R:L85	1.43	No	No	0	8	8
242	R:R:I228	R:R:L229	1.43	No	No	0	6	5
243	R:R:I455	R:R:L456	1.43	No	No	0	8	8
244	R:R:K166	R:R:L85	1.41	No	No	0	6	8
245	R:R:E384	R:R:T242	1.41	No	No	0	9	5
246	R:R:L106	R:R:L51	1.38	Yes	No	0	8	6
247	R:R:D447	R:R:L79	1.36	No	Yes	0	8	9
248	R:R:D207	R:R:N206	1.35	No	No	0	5	7
249	R:R:E122	R:R:L125	1.33	No	No	0	7	7
250	R:R:E109	R:R:N108	1.31	No	No	0	7	8
251	R:R:F181	R:R:V178	1.31	No	No	0	6	6
252	R:R:R233	R:R:V232	1.31	Yes	No	0	7	4
253	R:R:F74	R:R:T75	1.3	No	No	0	6	7
254	R:R:A107	R:R:W114	1.3	No	Yes	0	7	8
255	R:R:A119	R:R:W120	1.3	No	Yes	0	5	6
256	R:R:F407	R:R:T410	1.3	No	No	0	7	7
257	R:R:R163	R:R:T161	1.29	No	No	0	5	8
258	R:R:R164	R:R:T161	1.29	No	No	0	8	8
259	R:R:N157	R:R:R160	1.21	No	Yes	0	7	7
260	R:R:I123	R:R:W120	1.17	No	Yes	0	6	6
261	R:R:Q381	R:R:R380	1.17	No	No	0	6	5
262	R:R:N206	R:R:Y211	1.16	No	No	0	7	8
263	R:R:F116	R:R:Y115	1.03	Yes	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T62	4.9475	4	5	8
2	R:R:N66	5.56	4	5	9
3	R:R:L68	4.44	4	0	8
4	R:R:L79	6.83	4	6	9
5	R:R:N84	3.8475	4	6	9
6	R:R:F86	5.965	4	0	8
7	R:R:S89	5.6925	4	7	9
8	R:R:D94	7.7575	4	5	9
9	R:R:V101	4.9425	4	1	8
10	R:R:I102	3.0225	4	1	8
11	R:R:F104	5.3575	4	2	7
12	R:R:L106	2.47	4	0	8
13	R:R:W114	6.34833	6	2	8
14	R:R:F116	6.164	5	2	7
15	R:R:W120	5.1275	4	2	6
16	R:R:I136	6.915	4	3	9
17	R:R:H138	5.49	4	0	8
18	R:R:Y147	7.355	4	0	8
19	R:R:Y156	5.708	5	4	9
20	R:R:R160	5.05333	6	4	7
21	R:R:W173	4.015	4	7	9
22	R:R:S176	3.6225	4	9	8
23	R:R:C203	5.57	4	2	9
24	R:R:C216	4.31	4	0	7
25	R:R:F220	8.75571	7	3	9
26	R:R:V230	3.4025	4	10	8
27	R:R:Y231	7.4625	4	10	9
28	R:R:R233	6.2875	4	0	7
29	R:R:Y235	5.655	4	0	8
30	R:R:F398	3.52333	6	3	9
31	R:R:W402	8.11	6	3	9
32	R:R:F405	5.075	4	1	8
33	R:R:F406	9.768	5	3	8
34	R:R:Y409	5.148	5	1	8
35	R:R:F426	6.535	4	0	7
36	R:R:W428	3.476	5	1	7
37	R:R:Y431	4.585	4	1	8
38	R:R:N437	4.135	4	0	9
39	R:R:Y441	6.9	4	0	9
40	R:R:F448	7.662	5	6	8
41	L:L:?1	6.61333	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:W428	11.0053	2.28	Yes	Yes	0	8	7
2	R:R:W428	R:R:Y431	59.0002	1.93	Yes	Yes	1	7	8
3	R:R:V101	R:R:Y431	44.6853	6.31	Yes	Yes	1	8	8
4	R:R:V101	R:R:V97	80.4561	3.21	Yes	No	0	8	8
5	R:R:D94	R:R:V97	49.9471	2.92	Yes	No	0	9	8
6	R:R:D94	R:R:T62	19.2629	4.34	Yes	Yes	5	9	8
7	R:R:S435	R:R:T62	11.6767	9.59	No	Yes	0	8	8
8	R:R:D94	R:R:N66	23.0688	13.46	Yes	Yes	5	9	9
9	L:L:?1	R:R:Y431	100	4.35	Yes	Yes	1	0	8
10	L:L:?1	R:R:C132	84.2766	11.78	Yes	No	0	0	7
11	R:R:C132	R:R:W402	84.802	3.92	No	Yes	0	7	9
12	R:R:I136	R:R:W402	30.1149	17.62	Yes	Yes	3	9	9
13	R:R:F398	R:R:I136	64.7437	2.51	Yes	Yes	3	9	9
14	R:R:F398	R:R:L139	64.1854	4.87	Yes	No	0	9	8
15	R:R:L139	R:R:Y441	72.91	9.38	No	Yes	0	8	9
16	R:R:L87	R:R:Y441	68.2175	2.34	No	Yes	0	8	9
17	R:R:F448	R:R:L87	65.5428	2.44	Yes	No	0	8	8
18	R:R:F448	R:R:T442	33.2932	10.38	Yes	No	0	8	9
19	R:R:F452	R:R:T442	30.5163	7.78	No	No	0	8	9
20	R:R:F452	R:R:L68	22.1529	12.18	No	Yes	0	8	8
21	L:L:?1	R:R:S219	69.356	5.57	Yes	No	0	0	8
22	R:R:F406	R:R:S219	62.2295	5.28	Yes	No	0	8	8
23	R:R:F406	R:R:I136	35.0301	2.51	Yes	Yes	3	8	9
24	R:R:F220	R:R:W402	31.8044	5.01	Yes	Yes	3	9	9
25	R:R:F220	R:R:F398	74.304	3.22	Yes	Yes	3	9	9
26	R:R:F220	R:R:F406	36.497	24.65	Yes	Yes	3	9	8
27	R:R:N433	R:R:W402	28.2686	5.65	No	Yes	0	9	9
28	R:R:N433	R:R:N437	27.4512	2.72	No	Yes	0	9	9
29	R:R:L139	R:R:N437	17.7814	4.12	No	Yes	0	8	9
30	R:R:I440	R:R:N437	18.566	2.83	No	Yes	0	8	9
31	R:R:I440	R:R:Y441	15.9569	12.09	No	Yes	0	8	9
32	R:R:I95	R:R:N66	11.7168	2.83	No	Yes	0	8	9
33	R:R:F131	R:R:V97	26.9367	11.8	No	No	0	7	8
34	R:R:F131	R:R:L96	15.3695	13.4	No	No	8	7	8
35	R:R:I95	R:R:L96	11.6512	2.85	No	No	0	8	8
36	R:R:I95	R:R:V67	15.4461	3.07	No	No	0	8	6
37	R:R:F448	R:R:N84	11.2717	3.62	Yes	Yes	6	8	9
38	R:R:F448	R:R:L79	16.9203	15.83	Yes	Yes	6	8	9
39	R:R:F398	R:R:M227	96.7415	3.73	Yes	No	0	9	9
40	R:R:M227	R:R:S143	84.8385	9.2	No	No	0	9	9
41	R:R:S143	R:R:V230	58.909	3.23	No	Yes	10	9	8
42	R:R:V230	R:R:Y147	49.0823	3.79	Yes	Yes	0	8	8
43	R:R:T151	R:R:Y147	35.7672	14.98	No	Yes	0	7	8
44	R:R:Q152	R:R:T151	33.7493	2.83	No	No	0	7	7
45	R:R:Q152	R:R:W148	31.7241	3.29	No	No	0	7	6
46	R:R:W148	R:R:Y156	27.6373	6.75	No	Yes	0	6	9
47	R:R:S219	R:R:T133	14.4864	4.8	No	No	0	8	8
48	R:R:S176	R:R:T133	10.8666	3.2	Yes	No	9	8	8
49	R:R:K424	R:R:W428	40.1058	4.64	No	Yes	0	7	7
50	R:R:E109	R:R:K424	38.4857	20.25	No	No	0	7	7
51	R:R:E109	R:R:N108	36.8692	1.31	No	No	0	7	8
52	R:R:N108	R:R:W114	34.9462	3.39	No	Yes	0	8	8
53	R:R:F116	R:R:W114	12.0598	13.03	Yes	Yes	2	7	8
54	L:L:?1	R:R:V129	10.2974	12.44	Yes	No	0	0	8
55	R:R:I226	R:R:V230	12.7386	1.54	No	Yes	0	8	8
56	R:R:C140	R:R:I226	10.6331	3.27	No	No	0	7	8
57	R:R:S143	R:R:Y231	24.2292	11.45	No	Yes	10	9	9
58	R:R:R164	R:R:Y156	12.381	3.09	No	Yes	0	8	9
59	R:R:V212	R:R:Y409	13.9974	10.09	No	Yes	0	7	8
60	R:R:V212	R:R:Y211	10.8301	2.52	No	No	0	7	8
61	R:R:C216	R:R:Y409	13.815	2.69	Yes	Yes	0	7	8
62	R:R:I395	R:R:M227	12.6729	1.46	No	No	0	7	9
63	R:R:L391	R:R:Y231	21.7333	8.21	No	Yes	0	8	9
64	R:R:L391	R:R:Y235	20.0328	3.52	No	Yes	0	8	8
65	R:R:F387	R:R:Y235	14.2273	2.06	No	Yes	0	8	8
66	R:R:E384	R:R:F387	10.4433	10.49	No	No	0	9	8
67	R:R:V394	R:R:Y441	16.4021	3.79	No	Yes	0	8	9
68	R:R:V390	R:R:V394	13.7201	1.6	No	No	0	8	8
69	R:R:F444	R:R:V390	11.3592	14.42	No	No	0	8	8
70	R:R:D447	R:R:L79	11.3665	1.36	No	Yes	0	8	9
71	L:L:?1	R:R:D128	44.2583	10.07	Yes	No	1	0	8
72	R:R:D128	R:R:V101	42.6309	8.76	No	Yes	1	8	8
73	R:R:C216	R:R:F406	10.8265	8.38	Yes	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D128	R:R:V101	8.76	1	No	Yes	8	8	1	2
R:R:V101	R:R:Y431	6.31	1	Yes	Yes	8	8	2	1
R:R:D128	R:R:Y431	5.75	1	No	Yes	8	8	1	1
L:L:?1	R:R:D128	10.07	1	Yes	No	0	8	0	1
R:R:S180	R:R:V129	8.08	0	No	No	8	8	2	1
L:L:?1	R:R:V129	12.44	1	Yes	No	0	8	0	1
R:R:C132	R:R:W402	3.92	0	No	Yes	7	9	1	2
L:L:?1	R:R:C132	11.78	1	Yes	No	0	7	0	1
R:R:S219	R:R:T133	4.8	0	No	No	8	8	1	2
R:R:I205	R:R:Y409	2.42	0	No	Yes	7	8	2	1
R:R:V212	R:R:Y409	10.09	0	No	Yes	7	8	2	1
L:L:?1	R:R:S215	4.18	1	Yes	No	0	9	0	1
R:R:C216	R:R:F406	8.38	0	Yes	Yes	7	8	2	2
R:R:C216	R:R:Y409	2.69	0	Yes	Yes	7	8	2	1
R:R:F406	R:R:S219	5.28	3	Yes	No	8	8	2	1
L:L:?1	R:R:S219	5.57	1	Yes	No	0	8	0	1
R:R:F406	R:R:W402	8.02	3	Yes	Yes	8	9	2	2
R:R:F405	R:R:Y409	6.19	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:F426	3.22	1	Yes	Yes	8	7	1	2
R:R:F405	R:R:F427	7.5	1	Yes	No	8	7	1	1
L:L:?1	R:R:F405	3.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	4.35	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F427	3.39	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y431	4.35	1	Yes	Yes	0	8	0	1
R:R:W428	R:R:Y431	1.93	1	Yes	Yes	7	8	2	1
R:R:A126	R:R:V129	1.7	0	No	No	8	8	2	1
R:R:I179	R:R:S215	1.55	0	No	No	8	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EJ0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.34
Number of Linked Nodes	234
Number of Links	263
Number of Hubs	41
Number of Links mediated by Hubs	149
Number of Communities	11
Number of Nodes involved in Communities	50
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	64923
Length Of Smallest Path	3
Average Path Length	14.1577
Length of Longest Path	25
Minimum Path Strength	1.235
Average Path Strength	5.82251
Maximum Path Strength	18.22
Minimum Path Correlation	0.7
Average Path Correlation	0.924066
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	43.3953
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.179
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• thioesterase binding • protein binding • binding • enzyme binding • adrenergic receptor binding • signaling receptor binding • alpha-1B adrenergic receptor binding • G protein-coupled receptor binding • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • protein heterodimerization activity • protein dimerization activity • protein-containing complex binding • heterotrimeric G-protein binding • identical protein binding • protein homodimerization activity • kinase binding • protein kinase binding • alpha-2C adrenergic receptor binding • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • epinephrine binding • hormone binding • trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling
Gene Ontology	Biological Process	• trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular process • positive regulation of response to wounding • wound healing • response to stimulus • positive regulation of biological process • regulation of response to wounding • positive regulation of response to stimulus • positive regulation of wound healing • regulation of response to stimulus • response to stress • regulation of response to stress • regulation of wound healing • response to wounding • cellular response to stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • thermoception • sensory perception • nervous system process • sensory perception of temperature stimulus • digestion • intestinal absorption • digestive system process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of cellular process • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • positive regulation of signaling • fear response • multicellular organismal response to stress • regulation of localization • regulation of calcium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of biological process • negative regulation of transport • establishment of localization • calcium ion transport • metal ion transport • negative regulation of calcium ion transport • localization • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of cellular process • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of body fluid levels • cell activation • hemostasis • blood coagulation • coagulation • platelet activation • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to morphine • response to isoquinoline alkaloid • response to chemical • response to nitrogen compound • response to alkaloid • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of protein metabolic process • positive regulation of membrane protein ectodomain proteolysis • macromolecule catabolic process • positive regulation of metabolic process • regulation of proteolysis • proteolysis • membrane protein proteolysis • positive regulation of macromolecule metabolic process • protein metabolic process • membrane protein ectodomain proteolysis • regulation of membrane protein ectodomain proteolysis • regulation of protein metabolic process • regulation of macromolecule metabolic process • protein catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • positive regulation of proteolysis • macromolecule metabolic process • regulation of protein catabolic process • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of uterine smooth muscle contraction • negative regulation of uterine smooth muscle contraction • negative regulation of smooth muscle contraction • negative regulation of multicellular organismal process • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • nucleobase-containing compound metabolic process • DNA replication • DNA metabolic process • nucleic acid metabolic process • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • cellular response to hormone stimulus • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of hormone secretion • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • signal release • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • Ras protein signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • establishment of localization in cell • intracellular glucose homeostasis • cellular response to oxygen-containing compound • cellular response to carbohydrate stimulus • response to glucose • insulin secretion involved in cellular response to glucose stimulus • cellular localization • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • negative regulation of response to stimulus • negative regulation of insulin secretion involved in cellular response to glucose stimulus • response to oxygen-containing compound • cellular response to glucose stimulus • response to hexose • cellular homeostasis • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • organic hydroxy compound transport • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • positive regulation of macromolecule biosynthetic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • positive regulation of cytokine production • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • response to alcohol • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction
Gene Ontology	Cellular Component	• postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • basal part of cell • basal plasma membrane • basolateral plasma membrane • dopaminergic synapse • intracellular anatomical structure • cytoplasm • glutamatergic synapse • protein-containing complex • receptor complex • somatodendritic compartment • cell body • neuronal cell body • GABA-ergic synapse • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • cell projection • distal axon • neuron projection terminus • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • parallel fiber to Purkinje cell synapse • excitatory synapse • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	E5E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	E5E
Name	Noradrenaline
Synonyms
Identifier
Formula	C8 H12 N O3
Molecular Weight	170.186
SMILES
PubChem	6921840
Formal Charge	1
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>7EJ0_nogp_Chain_R Y S L Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P P L R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS79948	-	-	2.7	2019-12-04	doi.org/10.1038/nature06325
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	doi.org/10.1038/nature06325
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Norepinephrine	-		3.2	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	doi.org/10.1126/sciadv.abj5347
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	doi.org/10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	doi.org/10.1126/science.abn7065
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9IQR	A	Amine	Adrenergic	α_2a	Homo sapiens	-	Muscarinic toxin 3	-	3.4	2025-07-23	To be published
	9PLN	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-	-	2.8	2025-08-20	To be published
	9PLO	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-	Go/β1/γ2	2.74	2025-08-20	To be published
	9PLO (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 168259594	-		2.74	2025-08-20	To be published
	9PQD	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 176491927	-	-	3.29	2025-08-20	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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