psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D128	6.64	Yes	Yes	1	0	8
2	L:L:?1	R:R:V129	13.37	Yes	No	1	0	8
3	L:L:?1	R:R:C132	7.77	Yes	No	0	0	7
4	L:L:?1	R:R:S215	3.68	Yes	No	0	0	9
5	L:L:?1	R:R:S219	3.68	Yes	No	0	0	8
6	L:L:?1	R:R:W402	4.65	Yes	Yes	1	0	9
7	L:L:?1	R:R:F405	11.93	Yes	Yes	1	0	8
8	L:L:?1	R:R:F406	6.96	Yes	Yes	1	0	8
9	L:L:?1	R:R:Y409	5.74	Yes	Yes	1	0	8
10	L:L:?1	R:R:F427	10.93	Yes	Yes	1	0	7
11	L:L:?1	R:R:Y431	7.65	Yes	Yes	1	0	8
12	R:R:L51	R:R:V47	4.47	No	No	0	6	5
13	R:R:T48	R:R:V110	3.17	No	No	0	4	7
14	R:R:C53	R:R:L49	3.17	No	No	0	5	5
15	R:R:V110	R:R:V52	3.21	No	No	0	7	6
16	R:R:A55	R:R:L106	3.15	No	No	0	5	8
17	R:R:I102	R:R:M59	7.29	No	Yes	0	8	7
18	R:R:M59	R:R:P103	3.35	Yes	No	0	7	9
19	R:R:L61	R:R:S435	4.5	No	No	0	5	8
20	R:R:A98	R:R:T62	3.36	No	No	0	9	8
21	R:R:S435	R:R:T62	9.59	No	No	0	8	8
22	R:R:I95	R:R:V63	4.61	No	No	0	8	7
23	R:R:F64	R:R:G65	4.52	No	No	0	5	9
24	R:R:A91	R:R:N66	4.69	No	Yes	0	9	9
25	R:R:D94	R:R:N66	14.81	No	Yes	0	9	9
26	R:R:I95	R:R:N66	5.66	No	Yes	0	8	9
27	R:R:N66	R:R:P438	13.03	Yes	No	0	9	9
28	R:R:I70	R:R:V67	3.07	No	No	0	8	6
29	R:R:I71	R:R:V67	3.07	No	No	0	7	6
30	R:R:F452	R:R:L68	4.87	No	No	0	8	8
31	R:R:T442	R:R:V69	4.76	No	No	0	9	9
32	R:R:V73	R:R:V88	4.81	No	No	0	8	7
33	R:R:L79	R:R:S76	7.51	Yes	No	0	9	8
34	R:R:K80	R:R:R77	8.66	No	No	0	7	8
35	R:R:L79	R:R:N84	6.87	Yes	No	2	9	9
36	R:R:D447	R:R:L79	13.57	Yes	Yes	2	8	9
37	R:R:F448	R:R:L79	13.4	Yes	Yes	2	8	9
38	R:R:P82	R:R:Q83	7.9	No	Yes	4	7	9
39	R:R:P82	R:R:R160	12.97	No	Yes	4	7	7
40	R:R:D145	R:R:Q83	6.53	No	Yes	0	9	9
41	R:R:Q83	R:R:R160	19.86	Yes	Yes	4	9	7
42	R:R:F448	R:R:N84	4.83	Yes	No	2	8	9
43	R:R:I165	R:R:L85	5.71	No	No	0	8	8
44	R:R:A141	R:R:F86	4.16	No	Yes	0	8	8
45	R:R:F86	R:R:I142	3.77	Yes	Yes	0	8	9
46	R:R:D145	R:R:F86	7.17	No	Yes	0	9	8
47	R:R:F86	R:R:I165	6.28	Yes	No	0	8	8
48	R:R:F86	R:R:I168	5.02	Yes	No	0	8	7
49	R:R:F86	R:R:I169	3.77	Yes	No	0	8	8
50	R:R:H138	R:R:S89	8.37	Yes	No	3	8	9
51	R:R:I169	R:R:S89	3.1	No	No	0	8	9
52	R:R:S89	R:R:W173	3.71	No	Yes	3	9	9
53	R:R:D94	R:R:L90	6.79	No	No	0	9	9
54	R:R:L90	R:R:N437	10.98	No	Yes	0	9	9
55	R:R:A93	R:R:S134	3.42	No	Yes	0	8	8
56	R:R:D94	R:R:S434	4.42	No	No	0	9	9
57	R:R:L100	R:R:L96	4.15	No	No	0	7	8
58	R:R:F131	R:R:L96	14.61	No	No	0	7	8
59	R:R:V101	R:R:V97	6.41	Yes	No	0	8	8
60	R:R:S434	R:R:V97	3.23	No	No	0	9	8
61	R:R:V101	R:R:Y124	7.57	Yes	Yes	1	8	7
62	R:R:D128	R:R:V101	10.22	Yes	Yes	1	8	8
63	R:R:V101	R:R:Y431	3.79	Yes	Yes	1	8	8
64	R:R:I102	R:R:Y431	9.67	No	Yes	0	8	8
65	R:R:F104	R:R:P103	4.33	No	No	0	7	9
66	R:R:F104	R:R:Y115	10.32	No	Yes	1	7	5
67	R:R:F104	R:R:Y124	4.13	No	Yes	1	7	7
68	R:R:S105	R:R:Y124	3.82	No	Yes	0	8	7
69	R:R:S105	R:R:Y431	5.09	No	Yes	0	8	8
70	R:R:N108	R:R:R202	8.44	No	No	0	8	5
71	R:R:E109	R:R:W428	7.63	No	No	0	7	7
72	R:R:W114	R:R:Y113	3.86	No	No	0	8	5
73	R:R:C121	R:R:Y115	9.41	No	Yes	1	9	5
74	R:R:Y115	R:R:Y124	10.92	Yes	Yes	1	5	7
75	R:R:C203	R:R:Y115	6.72	No	Yes	1	9	5
76	R:R:C121	R:R:C203	5.46	No	No	1	9	9
77	R:R:D128	R:R:Y124	5.75	Yes	Yes	1	8	7
78	R:R:F131	R:R:L127	4.87	No	No	0	7	7
79	R:R:D128	R:R:V129	4.38	Yes	No	1	8	8
80	R:R:D128	R:R:Y431	5.75	Yes	Yes	1	8	8
81	R:R:A177	R:R:L130	3.15	No	No	0	7	7
82	R:R:L130	R:R:S180	9.01	No	No	0	7	8
83	R:R:F131	R:R:W173	4.01	No	Yes	0	7	9
84	R:R:S176	R:R:T133	4.8	No	No	0	8	8
85	R:R:S219	R:R:T133	9.59	No	No	0	8	8
86	R:R:H138	R:R:S134	5.58	Yes	Yes	3	8	8
87	R:R:S134	R:R:W173	13.59	Yes	Yes	3	8	9
88	R:R:S134	R:R:S176	3.26	Yes	No	0	8	8
89	R:R:F220	R:R:I136	3.77	Yes	No	1	9	9
90	R:R:I136	R:R:P223	3.39	No	No	0	9	9
91	R:R:I136	R:R:W402	12.92	No	Yes	1	9	9
92	R:R:V137	R:R:V172	6.41	No	No	0	7	8
93	R:R:H138	R:R:V172	9.69	Yes	No	0	8	8
94	R:R:H138	R:R:W173	5.29	Yes	Yes	3	8	9
95	R:R:F398	R:R:L139	3.65	Yes	No	1	9	8
96	R:R:L139	R:R:N437	6.87	No	Yes	1	8	9
97	R:R:L139	R:R:Y441	8.21	No	Yes	1	8	9
98	R:R:C140	R:R:I226	4.91	No	No	0	7	8
99	R:R:I142	R:R:R146	3.76	Yes	No	1	9	9
100	R:R:I142	R:R:Y441	6.04	Yes	Yes	1	9	9
101	R:R:M227	R:R:S143	3.07	No	No	0	9	9
102	R:R:S143	R:R:V230	6.46	No	No	0	9	8
103	R:R:S143	R:R:Y231	7.63	No	Yes	0	9	9
104	R:R:L144	R:R:W148	7.97	No	No	0	7	6
105	R:R:D145	R:R:Y156	6.9	No	Yes	0	9	9
106	R:R:R146	R:R:Y231	6.17	No	Yes	0	9	9
107	R:R:R146	R:R:Y441	4.12	No	Yes	1	9	9
108	R:R:T151	R:R:Y147	12.48	No	No	0	7	8
109	R:R:V230	R:R:Y147	5.05	No	No	0	8	8
110	R:R:R233	R:R:Y147	12.35	No	No	0	7	8
111	R:R:W148	R:R:Y156	11.58	No	Yes	0	6	9
112	R:R:I150	R:R:I234	4.42	No	No	0	8	9
113	R:R:E155	R:R:Q152	6.37	No	No	0	6	7
114	R:R:E155	R:R:I154	5.47	No	No	0	6	7
115	R:R:R160	R:R:Y156	4.12	Yes	Yes	0	7	9
116	R:R:N157	R:R:R160	4.82	No	Yes	0	7	7
117	R:R:K159	R:R:L158	7.05	No	No	0	6	6
118	R:R:P162	R:R:T161	5.25	No	No	0	6	8
119	R:R:R163	R:R:T161	11.64	No	No	0	5	8
120	R:R:I168	R:R:R164	7.52	No	No	0	7	8
121	R:R:I179	R:R:S219	3.1	No	No	0	8	8
122	R:R:F181	R:R:S180	6.61	No	No	0	6	8
123	R:R:P182	R:R:Y211	4.17	No	Yes	0	8	8
124	R:R:E200	R:R:P201	4.72	No	No	0	3	3
125	R:R:E204	R:R:R202	8.14	No	No	0	4	5
126	R:R:D207	R:R:V212	5.84	No	No	1	5	7
127	R:R:D207	R:R:Y409	6.9	No	Yes	1	5	8
128	R:R:S215	R:R:Y211	7.63	No	Yes	0	9	8
129	R:R:V212	R:R:Y409	7.57	No	Yes	1	7	8
130	R:R:C216	R:R:F221	4.19	No	No	0	7	7
131	R:R:C216	R:R:F406	8.38	No	Yes	0	7	8
132	R:R:C216	R:R:T410	5.07	No	No	0	7	7
133	R:R:F221	R:R:I217	3.77	No	No	0	7	6
134	R:R:C224	R:R:F220	6.98	No	Yes	1	7	9
135	R:R:F220	R:R:F398	9.65	Yes	Yes	1	9	9
136	R:R:F220	R:R:W402	5.01	Yes	Yes	1	9	9
137	R:R:F220	R:R:F403	5.36	Yes	No	0	9	7
138	R:R:F220	R:R:F406	22.51	Yes	Yes	1	9	8
139	R:R:F221	R:R:F403	5.36	No	No	0	7	7
140	R:R:A222	R:R:P223	3.74	No	No	0	6	9
141	R:R:C224	R:R:F398	5.59	No	Yes	1	7	9
142	R:R:F398	R:R:M227	12.44	Yes	No	0	9	9
143	R:R:L391	R:R:Y231	5.86	No	Yes	0	8	9
144	R:R:V394	R:R:Y231	5.05	No	Yes	0	8	9
145	R:R:I395	R:R:Y231	9.67	No	Yes	0	7	9
146	R:R:F387	R:R:Y235	4.13	Yes	No	0	8	8
147	R:R:T388	R:R:Y235	11.24	No	No	0	8	8
148	R:R:L391	R:R:Y235	3.52	No	No	0	8	8
149	R:R:A238	R:R:F387	5.55	No	Yes	0	8	8
150	R:R:E384	R:R:K239	6.75	No	No	5	9	8
151	R:R:F387	R:R:K239	4.96	Yes	No	5	8	8
152	R:R:F387	R:R:T242	7.78	Yes	No	0	8	5
153	R:R:R383	R:R:R386	9.6	No	Yes	0	8	9
154	R:R:E384	R:R:F387	7	No	Yes	5	9	8
155	R:R:F389	R:R:R386	3.21	No	Yes	0	7	9
156	R:R:R386	R:R:V390	6.54	Yes	No	6	9	8
157	R:R:F444	R:R:R386	4.28	No	Yes	6	8	9
158	R:R:F389	R:R:V393	5.24	No	No	0	7	7
159	R:R:F444	R:R:V390	9.18	No	No	6	8	8
160	R:R:I440	R:R:V393	3.07	Yes	No	0	8	7
161	R:R:I440	R:R:V394	3.07	Yes	No	0	8	8
162	R:R:C401	R:R:N433	9.45	Yes	No	0	8	9
163	R:R:G430	R:R:W402	8.44	No	Yes	0	8	9
164	R:R:N433	R:R:W402	11.3	No	Yes	0	9	9
165	R:R:F403	R:R:F407	18.22	No	No	0	7	7
166	R:R:F426	R:R:P404	8.67	No	No	0	7	9
167	R:R:F405	R:R:F406	3.22	Yes	Yes	1	8	8
168	R:R:F405	R:R:Y409	8.25	Yes	Yes	1	8	8
169	R:R:F405	R:R:F423	6.43	Yes	No	0	8	6
170	R:R:F423	R:R:T408	6.49	No	No	0	6	7
171	R:R:C416	R:R:L411	7.94	No	No	0	8	7
172	R:R:C416	R:R:V414	3.42	No	No	0	8	5
173	R:R:K424	R:R:T421	13.51	No	No	0	7	5
174	R:R:F426	R:R:L422	8.53	No	No	0	7	7
175	R:R:F425	R:R:F429	8.57	No	No	0	6	8
176	R:R:F427	R:R:W428	4.01	Yes	No	1	7	7
177	R:R:F427	R:R:Y431	5.16	Yes	Yes	1	7	8
178	R:R:W428	R:R:Y431	10.61	No	Yes	1	7	8
179	R:R:N437	R:R:P438	4.89	Yes	No	0	9	9
180	R:R:N437	R:R:Y441	5.81	Yes	Yes	1	9	9
181	R:R:I443	R:R:V439	4.61	No	No	0	7	7
182	R:R:I440	R:R:Y441	3.63	Yes	Yes	0	8	9
183	R:R:F448	R:R:T442	10.38	Yes	No	0	8	9
184	R:R:F452	R:R:T442	10.38	No	No	0	8	9
185	R:R:D447	R:R:N445	14.81	Yes	No	2	8	9
186	R:R:F448	R:R:N445	12.08	Yes	No	2	8	9
187	R:R:H446	R:R:R449	3.39	No	No	0	6	9
188	R:R:D447	R:R:F448	8.36	Yes	Yes	2	8	8
189	R:R:K453	R:R:R449	6.19	No	No	0	6	9
190	R:R:A81	R:R:Q83	3.03	No	Yes	0	8	9
191	R:R:L90	R:R:S135	3	No	No	0	9	9
192	R:R:L411	R:R:V418	2.98	No	No	0	7	6
193	R:R:N84	R:R:V73	2.96	No	No	0	9	8
194	R:R:I150	R:R:I237	2.94	No	No	0	8	7
195	R:R:I228	R:R:I395	2.94	No	No	0	6	7
196	R:R:N66	R:R:T62	2.92	Yes	No	0	9	8
197	R:R:I226	R:R:L144	2.85	No	No	0	8	7
198	R:R:I234	R:R:L391	2.85	No	No	0	9	8
199	R:R:L106	R:R:M59	2.83	No	Yes	0	8	7
200	R:R:C432	R:R:F429	2.79	No	No	0	7	8
201	R:R:A72	R:R:F452	2.77	No	No	0	9	8
202	R:R:A126	R:R:F181	2.77	No	No	0	8	6
203	R:R:L127	R:R:L130	2.77	No	No	0	7	7
204	R:R:F398	R:R:V399	2.62	Yes	No	0	9	7
205	R:R:F426	R:R:T408	2.59	No	No	0	7	7
206	R:R:S149	R:R:Y156	2.54	No	Yes	0	9	9
207	R:R:F74	R:R:I70	2.51	No	No	0	6	8
208	R:R:F427	R:R:I205	2.51	Yes	No	0	7	7
209	R:R:F116	R:R:M111	2.49	No	No	0	7	7
210	R:R:F389	R:R:K385	2.48	No	No	0	7	7
211	R:R:F64	R:R:L68	2.44	No	No	0	5	8
212	R:R:F64	R:R:L456	2.44	No	No	0	5	8
213	R:R:D447	R:R:R450	2.38	Yes	No	0	8	6
214	R:R:L58	R:R:Y431	2.34	No	Yes	0	7	8
215	R:R:N206	R:R:Y211	2.33	No	Yes	0	7	8
216	R:R:K209	R:R:W210	2.32	No	No	0	5	5
217	R:R:C401	R:R:C432	1.82	Yes	No	0	8	7
218	R:R:A451	R:R:A72	1.79	No	No	0	8	9
219	R:R:P438	R:R:V69	1.77	No	No	0	9	9
220	R:R:P419	R:R:V418	1.77	No	No	0	7	6
221	R:R:G56	R:R:M59	1.75	No	Yes	0	6	7
222	R:R:G112	R:R:M111	1.75	No	No	0	6	7
223	R:R:A78	R:R:S76	1.71	No	No	0	7	8
224	R:R:C401	R:R:V397	1.71	Yes	No	0	8	8
225	R:R:C401	R:R:V400	1.71	Yes	No	0	8	5
226	R:R:L85	R:R:P162	1.64	No	No	0	8	6
227	R:R:L422	R:R:P419	1.64	No	No	0	7	7
228	R:R:A72	R:R:I455	1.62	No	No	0	9	8
229	R:R:S92	R:R:V88	1.62	No	No	0	7	7
230	R:R:A107	R:R:M111	1.61	No	No	0	7	7
231	R:R:V63	R:R:V67	1.6	No	No	0	7	6
232	R:R:V174	R:R:V178	1.6	No	No	0	5	6
233	R:R:T99	R:R:V63	1.59	No	No	0	6	7
234	R:R:C203	R:R:L125	1.59	No	No	0	9	7
235	R:R:T412	R:R:V418	1.59	No	No	0	5	6
236	R:R:C457	R:R:L456	1.59	No	No	0	6	8
237	R:R:A107	R:R:L106	1.58	No	No	0	7	8
238	R:R:A153	R:R:N157	1.56	No	No	0	9	7
239	R:R:I213	R:R:V212	1.54	No	No	0	7	7
240	R:R:I228	R:R:V232	1.54	No	No	0	6	4
241	R:R:I440	R:R:V439	1.54	Yes	No	0	8	7
242	R:R:I71	R:R:T75	1.52	No	No	0	7	7
243	R:R:I455	R:R:T75	1.52	No	No	0	8	7
244	R:R:I175	R:R:T171	1.52	No	No	0	7	5
245	R:R:L436	R:R:V397	1.49	No	No	0	7	8
246	R:R:I175	R:R:I179	1.47	No	No	0	7	8
247	R:R:G117	R:R:Y115	1.45	No	Yes	0	7	5
248	R:R:I170	R:R:K166	1.45	No	No	0	5	6
249	R:R:I142	R:R:L87	1.43	Yes	No	0	9	8
250	R:R:I228	R:R:L229	1.43	No	No	0	6	5
251	R:R:Q152	R:R:T151	1.42	No	No	0	7	7
252	R:R:E109	R:R:K424	1.35	No	No	0	7	7
253	R:R:E109	R:R:N108	1.31	No	No	0	7	8
254	R:R:E384	R:R:N382	1.31	No	No	0	9	5
255	R:R:H446	R:R:N445	1.28	No	No	0	6	9
256	R:R:I237	R:R:R240	1.25	No	No	0	7	7
257	R:R:I237	R:R:R241	1.25	No	No	0	7	8
258	R:R:Q236	R:R:R233	1.17	No	No	0	6	7
259	R:R:Q208	R:R:Y211	1.13	No	Yes	0	6	8
260	R:R:Q208	R:R:W210	1.1	No	No	0	6	5
261	R:R:R202	R:R:R420	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.54545	11	1	0
2	R:R:M59	3.805	4	0	7
3	R:R:N66	8.222	5	0	9
4	R:R:L79	10.3375	4	2	9
5	R:R:Q83	9.33	4	4	9
6	R:R:F86	5.02833	6	0	8
7	R:R:V101	6.9975	4	1	8
8	R:R:Y115	7.764	5	1	5
9	R:R:Y124	6.438	5	1	7
10	R:R:D128	6.548	5	1	8
11	R:R:S134	6.4625	4	3	8
12	R:R:H138	7.2325	4	3	8
13	R:R:I142	3.75	4	1	9
14	R:R:Y156	6.285	4	0	9
15	R:R:R160	10.4425	4	4	7
16	R:R:W173	6.65	4	3	9
17	R:R:Y211	3.815	4	0	8
18	R:R:F220	8.88	6	1	9
19	R:R:Y231	6.876	5	0	9
20	R:R:R386	5.9075	4	6	9
21	R:R:F387	5.884	5	5	8
22	R:R:F398	6.79	5	1	9
23	R:R:C401	3.6725	4	0	8
24	R:R:W402	8.464	5	1	9
25	R:R:F405	7.4575	4	1	8
26	R:R:F406	10.2675	4	1	8
27	R:R:Y409	7.115	4	1	8
28	R:R:F427	5.6525	4	1	7
29	R:R:Y431	6.2575	8	1	8
30	R:R:N437	7.1375	4	1	9
31	R:R:I440	2.8275	4	0	8
32	R:R:Y441	5.562	5	1	9
33	R:R:D447	9.78	4	2	8
34	R:R:F448	9.81	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y431	39.1753	7.65	Yes	Yes	1	0	8
2	R:R:I102	R:R:Y431	20.384	9.67	No	Yes	0	8	8
3	R:R:I102	R:R:M59	18.2678	7.29	No	Yes	0	8	7
4	R:R:L106	R:R:M59	12.7263	2.83	No	Yes	0	8	7
5	L:L:?1	R:R:D128	19.6495	6.64	Yes	Yes	1	0	8
6	R:R:D128	R:R:Y124	12.9154	5.75	Yes	Yes	1	8	7
7	R:R:V101	R:R:V97	23.8455	6.41	Yes	No	0	8	8
8	R:R:S434	R:R:V97	23.111	3.23	No	No	0	9	8
9	R:R:D94	R:R:S434	22.8929	4.42	No	No	0	9	9
10	R:R:D94	R:R:N66	17.2206	14.81	No	Yes	0	9	9
11	R:R:V101	R:R:Y431	14.0208	3.79	Yes	Yes	1	8	8
12	R:R:I95	R:R:N66	15.2134	5.66	No	Yes	0	8	9
13	R:R:I95	R:R:V63	13.3445	4.61	No	No	0	8	7
14	L:L:?1	R:R:W402	45.9385	4.65	Yes	Yes	1	0	9
15	R:R:F220	R:R:W402	45.8876	5.01	Yes	Yes	1	9	9
16	R:R:F220	R:R:F398	100	9.65	Yes	Yes	1	9	9
17	R:R:F398	R:R:L139	69.9949	3.65	Yes	No	1	9	8
18	R:R:L139	R:R:N437	25.6854	6.87	No	Yes	1	8	9
19	R:R:N437	R:R:P438	49.64	4.89	Yes	No	0	9	9
20	R:R:P438	R:R:V69	43.1532	1.77	No	No	0	9	9
21	R:R:T442	R:R:V69	41.5824	4.76	No	No	0	9	9
22	R:R:F452	R:R:T442	17.5333	10.38	No	No	0	8	9
23	L:L:?1	R:R:F406	40.0916	6.96	Yes	Yes	1	0	8
24	R:R:F220	R:R:F406	53.5088	22.51	Yes	Yes	1	9	8
25	R:R:F448	R:R:T442	25.4963	10.38	Yes	No	0	8	9
26	R:R:L139	R:R:Y441	43.8877	8.21	No	Yes	1	8	9
27	R:R:I142	R:R:Y441	50.8618	6.04	Yes	Yes	1	9	9
28	R:R:F86	R:R:I142	58.323	3.77	Yes	Yes	0	8	9
29	R:R:D145	R:R:F86	32.7831	7.17	No	Yes	0	9	8
30	R:R:D145	R:R:Q83	12.4355	6.53	No	Yes	0	9	9
31	R:R:D145	R:R:Y156	18.7914	6.9	No	Yes	0	9	9
32	R:R:F86	R:R:I165	10.581	6.28	Yes	No	0	8	8
33	L:L:?1	R:R:S219	25.0091	3.68	Yes	No	0	0	8
34	R:R:S219	R:R:T133	18.755	9.59	No	No	0	8	8
35	R:R:S176	R:R:T133	17.2278	4.8	No	No	0	8	8
36	R:R:S134	R:R:S176	17.0533	3.26	Yes	No	0	8	8
37	R:R:I169	R:R:S89	20.0858	3.1	No	No	0	8	9
38	R:R:S134	R:R:W173	12.2027	13.59	Yes	Yes	3	8	9
39	R:R:S89	R:R:W173	13.439	3.71	No	Yes	3	9	9
40	R:R:F131	R:R:W173	15.2425	4.01	No	Yes	0	7	9
41	L:L:?1	R:R:F427	16.1734	10.93	Yes	Yes	1	0	7
42	R:R:F427	R:R:W428	12.7336	4.01	Yes	No	1	7	7
43	R:R:E109	R:R:W428	25.9181	7.63	No	No	0	7	7
44	R:R:E109	R:R:N108	15.1625	1.31	No	No	0	7	8
45	R:R:W428	R:R:Y431	17.0388	10.61	No	Yes	1	7	8
46	R:R:N108	R:R:R202	11.2574	8.44	No	No	0	8	5
47	R:R:Y115	R:R:Y124	12.4427	10.92	Yes	Yes	1	5	7
48	R:R:F131	R:R:L127	10.2902	4.87	No	No	0	7	7
49	R:R:R146	R:R:Y441	11.2574	4.12	No	Yes	1	9	9
50	R:R:F398	R:R:M227	38.099	12.44	Yes	No	0	9	9
51	R:R:M227	R:R:S143	36.9573	3.07	No	No	0	9	9
52	R:R:S143	R:R:V230	19.6131	6.46	No	No	0	9	8
53	R:R:S143	R:R:Y231	31.1541	7.63	No	Yes	0	9	9
54	R:R:V230	R:R:Y147	17.1624	5.05	No	No	0	8	8
55	R:R:T151	R:R:Y147	10.0865	12.48	No	No	0	7	8
56	R:R:L391	R:R:Y231	27.8671	5.86	No	Yes	0	8	9
57	R:R:I234	R:R:L391	10.4356	2.85	No	No	0	9	8
58	L:L:?1	R:R:S215	17.6569	3.68	Yes	No	0	0	9
59	R:R:S215	R:R:Y211	15.1262	7.63	No	Yes	0	9	8
60	R:R:I440	R:R:Y441	21.0748	3.63	Yes	Yes	0	8	9
61	R:R:L391	R:R:Y235	16.297	3.52	No	No	0	8	8
62	R:R:F387	R:R:Y235	12.4791	4.13	Yes	No	0	8	8
63	R:R:I440	R:R:V393	15.1044	3.07	Yes	No	0	8	7
64	R:R:F389	R:R:V393	13.0754	5.24	No	No	0	7	7
65	R:R:N433	R:R:W402	13.3299	11.3	No	Yes	0	9	9
66	R:R:C401	R:R:N433	11.6864	9.45	Yes	No	0	8	9
67	L:L:?1	R:R:F405	10.6174	11.93	Yes	Yes	1	0	8
68	R:R:F405	R:R:F423	20.4858	6.43	Yes	No	0	8	6
69	R:R:F423	R:R:T408	18.8859	6.49	No	No	0	6	7
70	R:R:F426	R:R:T408	17.0679	2.59	No	No	0	7	7
71	R:R:F426	R:R:L422	13.3808	8.53	No	No	0	7	7
72	R:R:L422	R:R:P419	11.5119	1.64	No	No	0	7	7
73	R:R:N66	R:R:P438	22.5365	13.03	Yes	No	0	9	9
74	R:R:F86	R:R:I169	20.0131	3.77	Yes	No	0	8	8
75	R:R:F405	R:R:F406	14.3335	3.22	Yes	Yes	1	8	8
76	R:R:N437	R:R:Y441	32.434	5.81	Yes	Yes	1	9	9
77	R:R:R146	R:R:Y231	20.1585	6.17	No	Yes	0	9	9
78	R:R:I142	R:R:R146	10.4138	3.76	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D128	6.64	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V129	13.37	1	Yes	No	0	8	0	1
L:L:?1	R:R:C132	7.77	1	Yes	No	0	7	0	1
L:L:?1	R:R:S215	3.68	1	Yes	No	0	9	0	1
L:L:?1	R:R:S219	3.68	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	4.65	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F405	11.93	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F406	6.96	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	5.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F427	10.93	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y431	7.65	1	Yes	Yes	0	8	0	1
R:R:V101	R:R:Y124	7.57	1	Yes	Yes	8	7	2	2
R:R:D128	R:R:V101	10.22	1	Yes	Yes	8	8	1	2
R:R:V101	R:R:Y431	3.79	1	Yes	Yes	8	8	2	1
R:R:I102	R:R:Y431	9.67	0	No	Yes	8	8	2	1
R:R:S105	R:R:Y124	3.82	0	No	Yes	8	7	2	2
R:R:S105	R:R:Y431	5.09	0	No	Yes	8	8	2	1
R:R:D128	R:R:Y124	5.75	1	Yes	Yes	8	7	1	2
R:R:D128	R:R:V129	4.38	1	Yes	No	8	8	1	1
R:R:D128	R:R:Y431	5.75	1	Yes	Yes	8	8	1	1
R:R:S219	R:R:T133	9.59	0	No	No	8	8	1	2
R:R:F220	R:R:I136	3.77	1	Yes	No	9	9	2	2
R:R:I136	R:R:W402	12.92	1	No	Yes	9	9	2	1
R:R:I179	R:R:S219	3.1	0	No	No	8	8	2	1
R:R:D207	R:R:V212	5.84	1	No	No	5	7	2	2
R:R:D207	R:R:Y409	6.9	1	No	Yes	5	8	2	1
R:R:S215	R:R:Y211	7.63	0	No	Yes	9	8	1	2
R:R:V212	R:R:Y409	7.57	1	No	Yes	7	8	2	1
R:R:C216	R:R:F406	8.38	0	No	Yes	7	8	2	1
R:R:F220	R:R:W402	5.01	1	Yes	Yes	9	9	2	1
R:R:F220	R:R:F406	22.51	1	Yes	Yes	9	8	2	1
R:R:G430	R:R:W402	8.44	0	No	Yes	8	9	2	1
R:R:N433	R:R:W402	11.3	0	No	Yes	9	9	2	1
R:R:F405	R:R:F406	3.22	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:Y409	8.25	1	Yes	Yes	8	8	1	1
R:R:F405	R:R:F423	6.43	1	Yes	No	8	6	1	2
R:R:F427	R:R:W428	4.01	1	Yes	No	7	7	1	2
R:R:F427	R:R:Y431	5.16	1	Yes	Yes	7	8	1	1
R:R:W428	R:R:Y431	10.61	1	No	Yes	7	8	2	1
R:R:F427	R:R:I205	2.51	1	Yes	No	7	7	1	2
R:R:L58	R:R:Y431	2.34	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9CBM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	237
Number of Links	261
Number of Hubs	34
Number of Links mediated by Hubs	130
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	33505
Length Of Smallest Path	3
Average Path Length	11.1902
Length of Longest Path	23
Minimum Path Strength	1.115
Average Path Strength	6.32443
Maximum Path Strength	16.08
Minimum Path Correlation	0.7
Average Path Correlation	0.909419
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	49.3623
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.3732
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • protein localization • protein localization to postsynaptic specialization membrane • cellular localization • protein localization to postsynaptic membrane • protein localization to cell periphery • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • cellular macromolecule localization
Gene Ontology	Biological Process	• protein localization • protein localization to postsynaptic specialization membrane • cellular localization • protein localization to postsynaptic membrane • protein localization to cell periphery • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • protein localization to organelle • cellular macromolecule localization • macromolecule localization • cellular process • protein localization to postsynapse • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • synapse • cell junction • glutamatergic synapse • postsynapse • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • G-protein beta-subunit binding • thioesterase binding • adrenergic receptor binding • signaling receptor binding • alpha-1B adrenergic receptor binding • G protein-coupled receptor binding • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • identical protein binding • protein homodimerization activity • kinase binding • protein kinase binding • alpha-2C adrenergic receptor binding • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • epinephrine binding • hormone binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • receptor transactivation • positive regulation of signaling receptor activity • regulation of signaling receptor activity • regulation of signal transduction • positive regulation of molecular function • regulation of molecular function • regulation of response to stimulus • positive regulation of response to wounding • wound healing • positive regulation of biological process • regulation of response to wounding • positive regulation of response to stimulus • positive regulation of wound healing • response to stress • regulation of response to stress • regulation of wound healing • response to wounding • regulation of protein modification process • positive regulation of phosphorylation • regulation of catalytic activity • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • activation of protein kinase B activity • positive regulation of protein kinase activity • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • positive regulation of cellular process • protein phosphorylation • positive regulation of transferase activity • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • positive regulation of catalytic activity • primary metabolic process • regulation of protein kinase activity • regulation of macromolecule metabolic process • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorylation • regulation of phosphorus metabolic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • thermoception • sensory perception of temperature stimulus • digestion • intestinal absorption • digestive system process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cell communication • positive regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • positive regulation of signaling • fear response • multicellular organismal response to stress • regulation of localization • regulation of calcium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of biological process • negative regulation of transport • establishment of localization • calcium ion transport • metal ion transport • negative regulation of calcium ion transport • localization • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of cellular process • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of body fluid levels • cell activation • hemostasis • blood coagulation • coagulation • platelet activation • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • response to morphine • response to isoquinoline alkaloid • response to alkaloid • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of membrane protein ectodomain proteolysis • macromolecule catabolic process • regulation of proteolysis • proteolysis • membrane protein proteolysis • membrane protein ectodomain proteolysis • regulation of membrane protein ectodomain proteolysis • protein catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • positive regulation of proteolysis • regulation of protein catabolic process • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of uterine smooth muscle contraction • negative regulation of uterine smooth muscle contraction • negative regulation of smooth muscle contraction • negative regulation of multicellular organismal process • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • nucleobase-containing compound metabolic process • DNA replication • DNA metabolic process • nucleic acid metabolic process • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • regulation of calcium ion transmembrane transporter activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • negative regulation of transmembrane transport • regulation of transporter activity • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cation transmembrane transport • regulation of monoatomic ion transmembrane transporter activity • negative regulation of transporter activity • negative regulation of molecular function • inorganic ion transmembrane transport • inorganic cation transmembrane transport • transmembrane transport • regulation of transmembrane transport • regulation of monoatomic cation transmembrane transport • negative regulation of calcium ion transmembrane transport • calcium ion transmembrane transport • protein localization • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • signal release • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • Ras protein signal transduction • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • regulation of MAP kinase activity • positive regulation of protein serine/threonine kinase activity • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of protein serine/threonine kinase activity • regulation of intracellular signal transduction • MAPK cascade • establishment of localization in cell • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • response to glucose • insulin secretion involved in cellular response to glucose stimulus • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • negative regulation of response to stimulus • negative regulation of insulin secretion involved in cellular response to glucose stimulus • cellular response to glucose stimulus • response to hexose • cellular homeostasis • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • organic hydroxy compound transport • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • positive regulation of macromolecule biosynthetic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • positive regulation of cytokine production • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • basal part of cell • basal plasma membrane • basolateral plasma membrane • dopaminergic synapse • receptor complex • somatodendritic compartment • cell body • neuronal cell body • GABA-ergic synapse • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • axon • axon terminus • distal axon • neuron projection terminus • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08913
Sequence	>9CBM_nogp_Chain_R V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S R A L K A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G Y W Y F G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q A I E Y N L K R T P R R I K A I I I T V W V I S A V I S F P E P R C E I N D Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G C S V P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F R R A F K K I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9CBM	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBM (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.2	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-	Gi1/β1/γ2	2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	9CBL (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Epinephrine	-		2.8	2024-09-11	doi.org/10.1038/s12276-024-01296-x
	7W7E	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-	Go/β1/γ2	3.4	2022-09-28	10.1126/science.abn7065
	7W7E (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 164946676	-		3.4	2022-09-28	10.1126/science.abn7065
	7W6P	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-	Go/β1/γ2	3.47	2022-09-28	10.1126/science.abn7065
	7W6P (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	N-pyridin-4-ylisoquinolin-4-amine	-		3.47	2022-09-28	10.1126/science.abn7065
	7EJK	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-	Go/β1/γ2	3.4	2022-04-13	10.1126/sciadv.abj5347
	7EJK (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Oxymetazoline	-		3.4	2022-04-13	10.1126/sciadv.abj5347
	7EJA	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	3.6	2022-04-13	10.1126/sciadv.abj5347
	7EJA (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Dexmedetomidine	-		3.6	2022-04-13	10.1126/sciadv.abj5347
	7EJ8	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-	Go/β1/γ2	3	2022-04-13	10.1126/sciadv.abj5347
	7EJ8 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	Brimonidine	-		3	2022-04-13	10.1126/sciadv.abj5347
	7EJ0	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-	Go/β1/γ2	3.2	2022-04-13	10.1126/sciadv.abj5347
	7EJ0 (No Gprot)	A	Amine	Adrenergic	α_2a	Homo sapiens	L-Norepinephrine	-		3.2	2022-04-13	10.1126/sciadv.abj5347
	6KUY	A	Amine	Adrenergic	α_2a	Homo sapiens	PubChem 145704643	-	-	3.2	2019-12-04	10.1038/nature06325
	6KUX	A	Amine	Adrenergic	α_2a	Homo sapiens	RS-79948	-	-	2.7	2019-12-04	10.1038/nature06325

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9CBM_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.