psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:C6	7.28	No	Yes	0	0	0
2	L:L:Y2	R:R:Q92	19.16	Yes	Yes	2	0	7
3	L:L:Y2	R:R:Q96	14.65	Yes	Yes	2	0	7
4	L:L:Y2	R:R:Q119	5.64	Yes	Yes	2	0	7
5	L:L:Y2	R:R:F291	5.16	Yes	Yes	0	0	7
6	L:L:I3	R:R:Q171	8.23	Yes	Yes	5	0	6
7	L:L:I3	R:R:Y200	3.63	Yes	No	5	0	7
8	L:L:I3	R:R:I201	2.94	Yes	Yes	0	0	5
9	L:L:I3	R:R:I204	4.42	Yes	No	5	0	5
10	L:L:N5	L:L:Q4	6.6	No	No	0	0	0
11	L:L:Q4	R:R:Q295	15.36	No	No	0	0	6
12	L:L:Q4	R:R:S298	7.22	No	No	0	0	5
13	L:L:N5	R:R:W188	13.56	No	No	0	0	3
14	L:L:C6	L:L:G9	3.92	Yes	No	4	0	0
15	L:L:?10	L:L:C6	3.93	Yes	Yes	4	0	0
16	L:L:L8	R:R:I312	4.28	No	No	0	0	4
17	L:L:?10	L:L:G9	4.23	Yes	No	4	0	0
18	L:L:?10	R:R:E42	9.84	Yes	No	4	0	5
19	L:L:?10	R:R:I312	3.53	Yes	No	4	0	4
20	L:L:?10	R:R:L316	3.43	Yes	No	0	0	5
21	R:R:L38	R:R:N35	6.87	No	No	0	5	5
22	R:R:E36	R:R:R40	15.12	No	No	0	5	5
23	R:R:E42	R:R:L38	6.63	No	No	0	5	5
24	R:R:E42	R:R:I312	4.1	No	No	4	5	4
25	R:R:I101	R:R:V43	3.07	No	No	0	5	6
26	R:R:L46	R:R:L97	8.3	No	No	0	6	7
27	R:R:C323	R:R:I49	3.27	No	No	0	7	7
28	R:R:L50	R:R:L54	6.92	No	No	0	6	6
29	R:R:L50	R:R:V93	4.47	No	No	0	6	7
30	R:R:L50	R:R:L94	5.54	No	No	0	6	8
31	R:R:C323	R:R:L52	4.76	No	No	0	7	5
32	R:R:A53	R:R:C323	3.61	No	No	0	8	7
33	R:R:D85	R:R:N57	6.73	Yes	No	3	9	9
34	R:R:L86	R:R:N57	5.49	No	No	0	7	9
35	R:R:N57	R:R:P326	6.52	No	No	3	9	9
36	R:R:C59	R:R:M330	3.24	No	No	0	6	7
37	R:R:S82	R:R:V60	9.7	No	No	0	9	9
38	R:R:M330	R:R:V60	3.04	No	No	0	7	9
39	R:R:A63	R:R:L336	4.73	No	No	0	7	8
40	R:R:F75	R:R:S72	5.28	No	No	0	9	8
41	R:R:D136	R:R:R73	7.15	No	No	0	9	7
42	R:R:R73	R:R:Y153	9.26	No	No	0	7	7
43	R:R:F75	R:R:L336	7.31	No	No	0	9	8
44	R:R:F76	R:R:F77	5.36	No	Yes	0	5	8
45	R:R:F76	R:R:R150	7.48	No	No	0	5	4
46	R:R:F76	R:R:Y153	6.19	No	No	0	5	7
47	R:R:F77	R:R:L132	6.09	Yes	No	0	8	7
48	R:R:F77	R:R:M133	8.71	Yes	No	0	8	8
49	R:R:D136	R:R:F77	10.75	No	Yes	0	9	8
50	R:R:M78	R:R:Y329	4.79	No	Yes	0	7	9
51	R:R:H80	R:R:L129	9	Yes	No	0	9	8
52	R:R:H80	R:R:V157	12.45	Yes	No	0	9	7
53	R:R:H80	R:R:W161	3.17	Yes	No	0	9	9
54	R:R:D85	R:R:L81	6.79	Yes	No	0	9	9
55	R:R:L129	R:R:L81	5.54	No	No	0	8	9
56	R:R:D85	R:R:S322	11.78	Yes	No	3	9	9
57	R:R:D85	R:R:P326	4.83	Yes	No	3	9	9
58	R:R:V87	R:R:W161	3.68	No	No	0	6	9
59	R:R:S126	R:R:V88	3.23	No	No	3	9	7
60	R:R:S322	R:R:V88	4.85	No	No	3	9	7
61	R:R:F91	R:R:V90	5.24	No	No	0	5	5
62	R:R:F91	R:R:L118	20.7	No	No	0	5	5
63	R:R:Q119	R:R:Q92	7.68	Yes	Yes	2	7	7
64	R:R:M123	R:R:Q92	16.31	No	Yes	0	6	7
65	R:R:Q92	R:R:S319	7.22	Yes	No	0	7	7
66	R:R:S319	R:R:V93	3.23	No	No	0	7	7
67	R:R:P95	R:R:Q96	6.32	No	Yes	2	4	7
68	R:R:P95	R:R:V115	3.53	No	No	2	4	6
69	R:R:P95	R:R:Q119	6.32	No	Yes	2	4	7
70	R:R:K116	R:R:Q96	4.07	No	Yes	2	4	7
71	R:R:Q119	R:R:Q96	11.52	Yes	Yes	2	7	7
72	R:R:I101	R:R:L97	4.28	No	No	0	5	7
73	R:R:L98	R:R:T102	4.42	No	No	0	4	6
74	R:R:R104	R:R:W99	6	No	No	0	5	5
75	R:R:D186	R:R:W99	8.93	No	No	0	4	5
76	R:R:D100	R:R:L316	4.07	No	No	0	5	5
77	R:R:R104	R:R:Y106	4.12	No	No	0	5	3
78	R:R:R104	R:R:V184	6.54	No	No	0	5	3
79	R:R:F105	R:R:G107	4.52	Yes	No	0	7	6
80	R:R:F105	R:R:L111	7.31	Yes	No	0	7	5
81	R:R:C112	R:R:F105	4.19	No	Yes	0	9	7
82	R:R:D186	R:R:F105	3.58	No	Yes	0	4	7
83	R:R:G107	R:R:P108	4.06	No	No	0	6	7
84	R:R:L111	R:R:P108	8.21	No	No	0	5	7
85	R:R:D109	R:R:R113	17.87	No	No	0	4	6
86	R:R:D109	R:R:L177	21.71	No	No	0	4	4
87	R:R:L111	R:R:V115	2.98	No	No	0	5	6
88	R:R:C112	R:R:C187	5.46	No	No	0	9	9
89	R:R:R113	R:R:V172	3.92	No	No	0	6	5
90	R:R:Q119	R:R:V115	4.3	Yes	No	2	7	6
91	R:R:K116	R:R:Q119	9.49	No	Yes	2	4	7
92	R:R:L165	R:R:Y117	7.03	No	Yes	0	3	7
93	R:R:S168	R:R:Y117	8.9	No	Yes	0	7	7
94	R:R:V172	R:R:Y117	6.31	No	Yes	0	5	7
95	R:R:S168	R:R:V120	6.46	No	No	0	7	5
96	R:R:Q171	R:R:V120	10.03	Yes	No	0	6	5
97	R:R:S168	R:R:V121	4.85	No	No	0	7	6
98	R:R:F124	R:R:Y128	11.35	Yes	No	0	6	6
99	R:R:A167	R:R:F124	8.32	No	Yes	0	5	6
100	R:R:F124	R:R:V208	5.24	Yes	No	0	6	5
101	R:R:A125	R:R:W161	5.19	No	No	0	7	9
102	R:R:S126	R:R:S322	3.26	No	No	3	9	9
103	R:R:P212	R:R:T127	3.5	No	No	0	9	8
104	R:R:F284	R:R:T127	3.89	No	No	1	9	8
105	R:R:T127	R:R:W288	4.85	No	Yes	1	8	8
106	R:R:C164	R:R:Y128	5.38	No	No	0	8	6
107	R:R:L130	R:R:N325	5.49	No	No	0	8	9
108	R:R:L131	R:R:V215	10.43	No	No	0	7	6
109	R:R:A156	R:R:L132	3.15	No	No	0	5	7
110	R:R:M133	R:R:Y329	7.18	No	Yes	0	8	9
111	R:R:L216	R:R:S134	3	Yes	No	1	8	8
112	R:R:C219	R:R:S134	3.44	Yes	No	0	6	8
113	R:R:S134	R:R:Y220	6.36	No	Yes	1	8	9
114	R:R:C219	R:R:L135	3.17	Yes	No	0	6	6
115	R:R:R137	R:R:Y220	5.14	No	Yes	0	9	9
116	R:R:C138	R:R:C219	7.28	No	Yes	0	7	6
117	R:R:C138	R:R:L222	3.17	No	No	0	7	6
118	R:R:C138	R:R:I223	4.91	No	No	0	7	8
119	R:R:L139	R:R:Q143	3.99	No	No	0	3	5
120	R:R:I141	R:R:I223	2.94	No	No	0	8	8
121	R:R:C142	R:R:K226	4.85	No	No	0	7	6
122	R:R:T152	R:R:Y153	3.75	No	No	0	7	7
123	R:R:F175	R:R:Q171	10.54	No	Yes	0	6	6
124	R:R:Q171	R:R:Y200	10.15	Yes	No	5	6	7
125	R:R:H173	R:R:I174	3.98	No	No	0	5	5
126	R:R:A189	R:R:F175	8.32	No	No	0	5	6
127	R:R:S176	R:R:V190	3.23	No	No	0	5	4
128	R:R:F185	R:R:L177	6.09	No	No	0	3	4
129	R:R:R178	R:R:W188	6	No	No	0	3	3
130	R:R:E179	R:R:F185	3.5	No	No	0	3	3
131	R:R:F191	R:R:P197	26.01	No	No	0	6	5
132	R:R:I192	R:R:Q193	10.98	No	Yes	0	4	4
133	R:R:P194	R:R:Q193	3.16	No	Yes	6	4	4
134	R:R:Q193	R:R:W195	13.14	Yes	No	6	4	2
135	R:R:G196	R:R:Q193	3.29	No	Yes	0	4	4
136	R:R:P194	R:R:W195	4.05	No	No	6	4	2
137	R:R:G196	R:R:P197	4.06	No	No	0	4	5
138	R:R:K198	R:R:V299	7.59	No	No	0	4	4
139	R:R:K198	R:R:W300	8.12	No	No	0	4	5
140	R:R:I204	R:R:Y200	13.3	No	No	5	5	7
141	R:R:I201	R:R:Q295	6.86	Yes	No	0	5	6
142	R:R:I201	R:R:M296	2.92	Yes	No	0	5	6
143	R:R:I201	R:R:V299	9.22	Yes	No	0	5	4
144	R:R:M296	R:R:T202	3.01	No	No	0	6	5
145	R:R:I204	R:R:W203	3.52	No	No	0	5	4
146	R:R:F292	R:R:T205	9.08	Yes	No	0	7	5
147	R:R:M296	R:R:T205	4.52	No	No	0	6	5
148	R:R:V208	R:R:W288	4.9	No	Yes	1	5	8
149	R:R:F292	R:R:V208	5.24	Yes	No	1	7	5
150	R:R:V213	R:R:Y209	5.05	No	Yes	1	6	8
151	R:R:I285	R:R:Y209	6.04	No	Yes	1	6	8
152	R:R:P212	R:R:V211	3.53	No	No	0	9	5
153	R:R:I285	R:R:V213	4.61	No	No	1	6	6
154	R:R:L216	R:R:Y220	4.69	Yes	Yes	1	8	9
155	R:R:I280	R:R:L216	4.28	Yes	Yes	1	8	8
156	R:R:F284	R:R:L216	3.65	No	Yes	1	9	8
157	R:R:M276	R:R:Y220	3.59	No	Yes	0	8	9
158	R:R:T277	R:R:Y220	7.49	No	Yes	0	8	9
159	R:R:I280	R:R:Y220	13.3	Yes	Yes	1	8	9
160	R:R:S224	R:R:T273	9.59	No	No	0	5	8
161	R:R:S224	R:R:T277	6.4	No	No	0	5	8
162	R:R:F225	R:R:Q229	4.68	No	No	0	4	5
163	R:R:K226	R:R:Q229	4.07	No	No	0	6	5
164	R:R:I227	R:R:K270	4.36	No	No	0	8	8
165	R:R:I227	R:R:T273	4.56	No	No	0	8	8
166	R:R:V274	R:R:W228	4.9	No	No	0	7	6
167	R:R:K275	R:R:R272	3.71	No	No	7	8	8
168	R:R:F332	R:R:R272	5.34	No	No	7	7	8
169	R:R:F332	R:R:K275	7.44	No	No	7	7	8
170	R:R:F332	R:R:M276	4.98	No	No	0	7	8
171	R:R:F278	R:R:L282	3.65	No	No	0	6	5
172	R:R:I279	R:R:I280	2.94	No	Yes	0	7	8
173	R:R:I280	R:R:Y329	4.84	Yes	Yes	0	8	9
174	R:R:F284	R:R:W288	15.03	No	Yes	1	9	8
175	R:R:C287	R:R:L320	3.17	No	No	0	8	5
176	R:R:C287	R:R:N321	9.45	No	No	0	8	9
177	R:R:F292	R:R:W288	6.01	Yes	Yes	1	7	8
178	R:R:N321	R:R:W288	14.69	No	Yes	0	9	8
179	R:R:P290	R:R:T289	5.25	No	No	0	9	6
180	R:R:F291	R:R:F292	9.65	Yes	Yes	0	7	7
181	R:R:F291	R:R:M315	3.73	Yes	No	0	7	6
182	R:R:A318	R:R:F291	8.32	No	Yes	0	7	7
183	R:R:F293	R:R:V294	3.93	No	No	0	5	5
184	R:R:F293	R:R:W297	6.01	No	No	0	5	4
185	R:R:F311	R:R:V294	10.49	No	No	0	4	5
186	R:R:V294	R:R:V314	4.81	No	No	0	5	5
187	R:R:K306	R:R:S298	4.59	No	No	0	4	5
188	R:R:N325	R:R:P326	3.26	No	No	0	9	9
189	R:R:N325	R:R:Y329	6.98	No	Yes	0	9	9
190	R:R:H335	R:R:T333	6.85	No	No	0	6	8
191	R:R:L336	R:R:T333	5.9	No	No	0	8	8
192	R:R:F337	R:R:H338	7.92	No	No	0	8	5
193	R:R:W288	R:R:Y209	2.89	Yes	Yes	1	8	8
194	R:R:L316	R:R:M315	2.83	No	No	0	5	6
195	R:R:A140	R:R:R73	2.77	No	No	0	8	7
196	R:R:L114	R:R:L118	2.77	No	No	0	5	5
197	R:R:A207	R:R:F124	2.77	No	Yes	0	4	6
198	R:R:A189	R:R:F191	2.77	No	No	0	5	6
199	R:R:D301	R:R:K306	2.77	No	No	0	4	4
200	R:R:L317	R:R:L320	2.77	No	No	0	7	5
201	R:R:D100	R:R:L46	2.71	No	No	0	5	6
202	R:R:P305	R:R:W297	2.7	No	No	0	4	4
203	R:R:A169	R:R:Y117	2.67	No	Yes	0	4	7
204	R:R:H80	R:R:I83	2.65	Yes	No	0	9	6
205	R:R:F311	R:R:S298	2.64	No	No	0	4	5
206	R:R:F91	R:R:V87	2.62	No	No	0	5	6
207	R:R:R178	R:R:V190	2.62	No	No	0	3	4
208	R:R:A199	R:R:W195	2.59	No	No	0	4	2
209	R:R:A304	R:R:W297	2.59	No	No	0	3	4
210	R:R:F191	R:R:I174	2.51	No	No	0	6	5
211	R:R:F337	R:R:L62	2.44	No	No	0	8	4
212	R:R:L62	R:R:R65	2.43	No	No	0	4	2
213	R:R:L74	R:R:R137	2.43	No	No	0	8	9
214	R:R:M330	R:R:W327	2.33	No	No	0	7	6
215	R:R:R150	R:R:R154	2.13	No	No	0	4	3
216	R:R:A125	R:R:G122	1.95	No	No	0	7	6
217	L:L:C6	L:L:P7	1.88	Yes	No	0	0	0
218	R:R:A169	R:R:P170	1.87	No	No	0	4	7
219	R:R:A308	R:R:P305	1.87	No	No	0	2	4
220	R:R:G56	R:R:S55	1.86	No	No	0	8	4
221	R:R:G221	R:R:S224	1.86	No	No	0	3	5
222	R:R:G163	R:R:V166	1.84	No	No	0	4	3
223	R:R:C219	R:R:V215	1.71	Yes	No	0	6	6
224	R:R:C287	R:R:V286	1.71	No	No	0	8	6
225	R:R:A217	R:R:V281	1.7	No	No	0	4	8
226	R:R:C219	R:R:T218	1.69	Yes	No	0	6	4
227	R:R:C324	R:R:I328	1.64	No	No	0	6	8
228	R:R:A283	R:R:I328	1.62	No	No	0	6	8
229	R:R:V41	R:R:V45	1.6	No	No	0	5	4
230	R:R:C47	R:R:L51	1.59	No	No	0	4	4
231	R:R:T160	R:R:V157	1.59	No	No	0	7	7
232	R:R:T273	R:R:V274	1.59	No	No	0	8	7
233	R:R:A89	R:R:L54	1.58	No	No	0	7	6
234	R:R:A84	R:R:L129	1.58	No	No	0	8	8
235	R:R:P144	R:R:Q143	1.58	No	No	0	9	5
236	R:R:A39	R:R:N35	1.56	No	No	0	5	5
237	R:R:I49	R:R:S319	1.55	No	No	0	7	7
238	R:R:I285	R:R:V281	1.54	No	No	0	6	8
239	R:R:C142	R:R:Q143	1.53	No	No	0	7	5
240	R:R:I214	R:R:T218	1.52	No	No	0	3	4
241	R:R:L38	R:R:S309	1.5	No	No	0	5	2
242	R:R:L162	R:R:V166	1.49	No	No	0	4	3
243	R:R:L206	R:R:V211	1.49	No	No	0	5	5
244	R:R:I279	R:R:I328	1.47	No	No	0	7	8
245	R:R:I83	R:R:K79	1.45	No	No	0	6	6
246	R:R:I210	R:R:L206	1.43	No	No	0	5	5
247	R:R:I313	R:R:L317	1.43	No	No	0	5	7
248	R:R:A39	R:R:F103	1.39	No	No	0	5	4
249	R:R:L48	R:R:L51	1.38	No	No	0	4	4
250	R:R:L51	R:R:L52	1.38	No	No	0	4	5
251	L:L:L8	R:R:E307	1.33	No	No	0	0	4
252	R:R:T289	R:R:Y209	1.25	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	11.1525	4	2	0
2	L:L:I3	4.805	4	5	0
3	L:L:C6	4.2525	4	4	0
4	L:L:?10	4.992	5	4	0
5	R:R:F77	7.7275	4	0	8
6	R:R:H80	6.8175	4	0	9
7	R:R:D85	7.5325	4	3	9
8	R:R:Q92	12.5925	4	2	7
9	R:R:Q96	9.14	4	2	7
10	R:R:F105	4.9	4	0	7
11	R:R:Y117	6.2275	4	0	7
12	R:R:Q119	7.49167	6	2	7
13	R:R:F124	6.92	4	0	6
14	R:R:Q171	9.7375	4	5	6
15	R:R:Q193	7.6425	4	6	4
16	R:R:I201	5.485	4	0	5
17	R:R:Y209	3.8075	4	1	8
18	R:R:L216	3.905	4	1	8
19	R:R:C219	3.458	5	0	6
20	R:R:Y220	6.76167	6	1	9
21	R:R:I280	6.34	4	1	8
22	R:R:W288	8.06167	6	1	8
23	R:R:F291	6.715	4	0	7
24	R:R:F292	7.495	4	1	7
25	R:R:Y329	5.9475	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?10	R:R:L316	26.9866	3.43	Yes	No	0	0	5
2	R:R:L316	R:R:M315	37.2291	2.83	No	No	0	5	6
3	R:R:F291	R:R:M315	38.6145	3.73	Yes	No	0	7	6
4	L:L:Y2	R:R:F291	59.1687	5.16	Yes	Yes	0	0	7
5	L:L:Y2	R:R:Q92	26.4127	19.16	Yes	Yes	2	0	7
6	L:L:Y2	R:R:Q119	26.9866	5.64	Yes	Yes	2	0	7
7	R:R:F291	R:R:F292	85.6408	9.65	Yes	Yes	0	7	7
8	R:R:F292	R:R:T205	83.6022	9.08	Yes	No	0	7	5
9	R:R:M296	R:R:T205	82.5928	4.52	No	No	0	6	5
10	R:R:I201	R:R:M296	80.5146	2.92	Yes	No	0	5	6
11	L:L:I3	R:R:I201	53.1222	2.94	Yes	Yes	0	0	5
12	L:L:I3	R:R:Q171	46.957	8.23	Yes	Yes	5	0	6
13	R:R:I201	R:R:Q295	33.5082	6.86	Yes	No	0	5	6
14	L:L:Q4	R:R:Q295	31.7467	15.36	No	No	0	0	6
15	L:L:Q4	R:R:S298	21.425	7.22	No	No	0	0	5
16	L:L:?10	R:R:E42	11.9842	9.84	Yes	No	4	0	5
17	R:R:E42	R:R:L38	10.1831	6.63	No	No	0	5	5
18	R:R:Q92	R:R:S319	25.334	7.22	Yes	No	0	7	7
19	R:R:I49	R:R:S319	14.0524	1.55	No	No	0	7	7
20	R:R:C323	R:R:I49	12.1029	3.27	No	No	0	7	7
21	R:R:S319	R:R:V93	10.1336	3.23	No	No	0	7	7
22	R:R:F292	R:R:W288	100	6.01	Yes	Yes	1	7	8
23	R:R:F284	R:R:W288	92.7758	15.03	No	Yes	1	9	8
24	R:R:F284	R:R:L216	95.5962	3.65	No	Yes	1	9	8
25	R:R:I280	R:R:L216	64.3741	4.28	Yes	Yes	1	8	8
26	R:R:I280	R:R:Y329	68.5304	4.84	Yes	Yes	0	8	9
27	R:R:N325	R:R:Y329	47.9664	6.98	No	Yes	0	9	9
28	R:R:N325	R:R:P326	44.7501	3.26	No	No	0	9	9
29	R:R:D85	R:R:P326	39.0401	4.83	Yes	No	3	9	9
30	R:R:M133	R:R:Y329	23.7011	7.18	No	Yes	0	8	9
31	R:R:F77	R:R:M133	21.9693	8.71	Yes	No	0	8	8
32	R:R:F76	R:R:F77	10.0643	5.36	No	Yes	0	5	8
33	R:R:D85	R:R:L81	32.0732	6.79	Yes	No	0	9	9
34	R:R:L129	R:R:L81	30.1831	5.54	No	No	0	8	9
35	R:R:H80	R:R:L129	26.3137	9	Yes	No	0	9	8
36	R:R:H80	R:R:W161	16.6254	3.17	Yes	No	0	9	9
37	R:R:V87	R:R:W161	10.7076	3.68	No	No	0	6	9
38	R:R:Q119	R:R:V115	24.5225	4.3	Yes	No	2	7	6
39	R:R:L111	R:R:V115	23.2162	2.98	No	No	0	5	6
40	R:R:F105	R:R:L111	17.5062	7.31	Yes	No	0	7	5
41	R:R:D186	R:R:F105	10.1336	3.58	No	Yes	0	4	7
42	R:R:Q171	R:R:V120	25.6507	10.03	Yes	No	0	6	5
43	R:R:S168	R:R:V120	23.8595	6.46	No	No	0	7	5
44	R:R:S168	R:R:Y117	20.0792	8.9	No	Yes	0	7	7
45	R:R:V172	R:R:Y117	12.281	6.31	No	Yes	0	5	7
46	R:R:R113	R:R:V172	10.282	3.92	No	No	0	6	5
47	R:R:F124	R:R:V208	10.1831	5.24	Yes	No	0	6	5
48	R:R:L216	R:R:S134	19.8615	3	Yes	No	1	8	8
49	R:R:C219	R:R:S134	24.2058	3.44	Yes	No	0	6	8
50	R:R:L216	R:R:Y220	20.0396	4.69	Yes	Yes	1	8	9
51	R:R:F175	R:R:Q171	23.8595	10.54	No	Yes	0	6	6
52	R:R:A189	R:R:F175	21.9792	8.32	No	No	0	5	6
53	R:R:A189	R:R:F191	20.0792	2.77	No	No	0	5	6
54	R:R:F191	R:R:P197	14.2603	26.01	No	No	0	6	5
55	R:R:G196	R:R:P197	12.281	4.06	No	No	0	4	5
56	R:R:G196	R:R:Q193	10.282	3.29	No	Yes	0	4	4
57	R:R:W288	R:R:Y209	14.1217	2.89	Yes	Yes	1	8	8
58	R:R:T277	R:R:Y220	16.0614	7.49	No	Yes	0	8	9
59	R:R:S224	R:R:T277	14.1217	6.4	No	No	0	5	8
60	R:R:S224	R:R:T273	10.1831	9.59	No	No	0	5	8
61	R:R:N321	R:R:W288	11.8654	14.69	No	Yes	0	9	8
62	R:R:F311	R:R:S298	15.7348	2.64	No	No	0	4	5
63	R:R:F311	R:R:V294	14.0722	10.49	No	No	0	4	5
64	R:R:F293	R:R:V294	10.1633	3.93	No	No	0	5	5
65	R:R:I280	R:R:Y220	10.8461	13.3	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y2	R:R:Q92	19.16	2	Yes	Yes	0	7	0	1
L:L:Y2	R:R:Q96	14.65	2	Yes	Yes	0	7	0	1
L:L:Y2	R:R:Q119	5.64	2	Yes	Yes	0	7	0	1
L:L:Y2	R:R:F291	5.16	2	Yes	Yes	0	7	0	1
L:L:I3	R:R:Q171	8.23	5	Yes	Yes	0	6	0	1
L:L:I3	R:R:Y200	3.63	5	Yes	No	0	7	0	1
L:L:I3	R:R:I201	2.94	5	Yes	Yes	0	5	0	1
L:L:I3	R:R:I204	4.42	5	Yes	No	0	5	0	1
L:L:Q4	R:R:Q295	15.36	0	No	No	0	6	0	1
L:L:Q4	R:R:S298	7.22	0	No	No	0	5	0	1
L:L:N5	R:R:W188	13.56	0	No	No	0	3	0	1
L:L:L8	R:R:I312	4.28	0	No	No	0	4	0	1
L:L:?10	R:R:E42	9.84	4	Yes	No	0	5	0	1
L:L:?10	R:R:I312	3.53	4	Yes	No	0	4	0	1
L:L:?10	R:R:L316	3.43	4	Yes	No	0	5	0	1
R:R:E42	R:R:L38	6.63	4	No	No	5	5	1	2
R:R:E42	R:R:I312	4.1	4	No	No	5	4	1	1
R:R:Q119	R:R:Q92	7.68	2	Yes	Yes	7	7	1	1
R:R:M123	R:R:Q92	16.31	0	No	Yes	6	7	2	1
R:R:Q92	R:R:S319	7.22	2	Yes	No	7	7	1	2
R:R:P95	R:R:Q96	6.32	2	No	Yes	4	7	2	1
R:R:P95	R:R:V115	3.53	2	No	No	4	6	2	2
R:R:P95	R:R:Q119	6.32	2	No	Yes	4	7	2	1
R:R:K116	R:R:Q96	4.07	2	No	Yes	4	7	2	1
R:R:Q119	R:R:Q96	11.52	2	Yes	Yes	7	7	1	1
R:R:D100	R:R:L316	4.07	0	No	No	5	5	2	1
R:R:Q119	R:R:V115	4.3	2	Yes	No	7	6	1	2
R:R:K116	R:R:Q119	9.49	2	No	Yes	4	7	2	1
R:R:Q171	R:R:V120	10.03	5	Yes	No	6	5	1	2
R:R:F175	R:R:Q171	10.54	0	No	Yes	6	6	2	1
R:R:Q171	R:R:Y200	10.15	5	Yes	No	6	7	1	1
R:R:R178	R:R:W188	6	0	No	No	3	3	2	1
R:R:I204	R:R:Y200	13.3	5	No	No	5	7	1	1
R:R:I201	R:R:Q295	6.86	0	Yes	No	5	6	1	1
R:R:I201	R:R:M296	2.92	0	Yes	No	5	6	1	2
R:R:I201	R:R:V299	9.22	0	Yes	No	5	4	1	2
R:R:I204	R:R:W203	3.52	5	No	No	5	4	1	2
R:R:F291	R:R:F292	9.65	0	Yes	Yes	7	7	1	2
R:R:F291	R:R:M315	3.73	0	Yes	No	7	6	1	2
R:R:A318	R:R:F291	8.32	0	No	Yes	7	7	2	1
R:R:K306	R:R:S298	4.59	0	No	No	4	5	2	1
R:R:L316	R:R:M315	2.83	0	No	No	5	6	1	2
R:R:F311	R:R:S298	2.64	0	No	No	4	5	2	1
L:L:L8	R:R:E307	1.33	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7QVM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	243
Number of Links	252
Number of Hubs	25
Number of Links mediated by Hubs	92
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	21913
Length Of Smallest Path	3
Average Path Length	12.8901
Length of Longest Path	31
Minimum Path Strength	1.38
Average Path Strength	6.34831
Maximum Path Strength	19.79
Minimum Path Correlation	0.7
Average Path Correlation	0.91096
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	42.866
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.4922
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?10
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30559
Sequence	>7QVM_nogp_Chain_R N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T R Q K H S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F R F Y G P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q P R R T Y R L A V L A T W L G C L V A S A P Q V H I F S L R E V F D C W A V F I Q P W G P K A Y I T W I T L A V Y I V P V I V L A T C Y G L I S F K I W Q N K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W D A N A P K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L F H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	doi.org/10.1038/s41586-019-1286-0
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	6TOT	A	Peptide	Orexin	OX₁	Homo sapiens	Lemborexant	-	-	2.22	2020-01-15	doi.org/10.1021/acs.jmedchem.9b01787
	9NOT	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.8	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	7QVM	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-	chim(NtGi1-Go-CtGq)/β1/γ2	3.25	2022-08-10	doi.org/10.1038/s41467-022-31325-0
	7QVM (No Gprot)	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-		3.25	2022-08-10	doi.org/10.1038/s41467-022-31325-0
	7RYC	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2022-03-09	doi.org/10.1038/s41594-022-00728-4
	7RYC (No Gprot)	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-		2.9	2022-03-09	doi.org/10.1038/s41594-022-00728-4
	6TPK	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Retosiban	-	-	3.2	2020-08-05	doi.org/10.1126/sciadv.abb5419

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7QVM_nogp.zip

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