psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C1	L:L:Y2	4.03	No	Yes	1	0	0
2	L:L:C1	L:L:C6	7.28	No	No	1	0	0
3	L:L:C1	R:R:Q96	7.63	No	Yes	1	0	7
4	L:L:I3	L:L:Y2	2.42	Yes	Yes	1	0	0
5	L:L:Y2	R:R:Q92	6.76	Yes	Yes	1	0	7
6	L:L:Y2	R:R:Q96	9.02	Yes	Yes	1	0	7
7	L:L:Y2	R:R:Q119	4.51	Yes	Yes	1	0	7
8	L:L:Y2	R:R:F291	2.06	Yes	Yes	1	0	7
9	L:L:Y2	R:R:A318	5.34	Yes	No	1	0	7
10	L:L:I3	R:R:Y200	4.84	Yes	Yes	1	0	7
11	L:L:I3	R:R:I201	2.94	Yes	Yes	0	0	5
12	L:L:I3	R:R:I204	5.89	Yes	No	1	0	5
13	L:L:Q4	R:R:Q295	7.68	No	No	0	0	6
14	L:L:Q4	R:R:V299	5.73	No	No	0	0	4
15	L:L:N5	R:R:W188	15.82	No	No	0	0	3
16	L:L:C6	L:L:P7	3.77	No	No	1	0	0
17	L:L:C6	R:R:M315	3.24	No	No	1	0	6
18	L:L:P7	R:R:I312	3.39	No	No	0	0	4
19	L:L:P7	R:R:M315	6.71	No	No	1	0	6
20	L:L:L8	R:R:F103	2.44	No	No	0	0	4
21	L:L:?10	L:L:G9	4.23	Yes	No	0	0	0
22	L:L:?10	R:R:N35	3.4	Yes	No	2	0	5
23	L:L:?10	R:R:L38	10.28	Yes	Yes	2	0	5
24	L:L:?10	R:R:A39	3.9	Yes	No	0	0	5
25	R:R:D182	R:R:P31	14.49	No	No	0	3	4
26	R:R:A39	R:R:R34	6.91	No	No	0	5	5
27	R:R:F103	R:R:R34	11.76	No	No	0	4	5
28	R:R:L38	R:R:N35	9.61	Yes	No	2	5	5
29	R:R:E36	R:R:R40	2.33	No	No	0	5	5
30	R:R:I313	R:R:V41	3.07	No	No	0	5	5
31	R:R:D100	R:R:E42	5.2	No	Yes	0	5	5
32	R:R:E42	R:R:I312	2.73	Yes	No	0	5	4
33	R:R:E42	R:R:L316	3.98	Yes	No	0	5	5
34	R:R:I101	R:R:V43	4.61	No	No	0	5	6
35	R:R:I49	R:R:V45	3.07	No	No	0	7	4
36	R:R:L46	R:R:V93	2.98	No	No	0	6	7
37	R:R:L46	R:R:L97	8.3	No	No	0	6	7
38	R:R:C47	R:R:L51	3.17	No	No	0	4	4
39	R:R:L50	R:R:L54	4.15	No	No	0	6	6
40	R:R:L50	R:R:V93	4.47	No	No	0	6	7
41	R:R:G56	R:R:S55	3.71	No	No	0	8	4
42	R:R:D85	R:R:N57	14.81	No	Yes	0	9	9
43	R:R:L86	R:R:N57	4.12	No	Yes	0	7	9
44	R:R:N57	R:R:P326	6.52	Yes	No	0	9	9
45	R:R:C59	R:R:L340	3.17	No	No	0	6	8
46	R:R:M330	R:R:V60	3.04	No	No	0	7	9
47	R:R:L61	R:R:S82	6.01	No	No	0	7	9
48	R:R:L62	R:R:R65	12.15	Yes	No	0	4	2
49	R:R:L340	R:R:L62	4.15	No	Yes	0	8	4
50	R:R:F344	R:R:L62	4.87	No	Yes	0	6	4
51	R:R:A63	R:R:L340	6.3	No	No	0	7	8
52	R:R:F75	R:R:L64	8.53	No	No	0	9	7
53	R:R:R343	R:R:T66	6.47	No	No	0	4	6
54	R:R:E339	R:R:T67	16.93	No	No	0	6	6
55	R:R:F75	R:R:K70	3.72	No	No	0	9	8
56	R:R:H335	R:R:K70	5.24	No	No	0	6	8
57	R:R:D136	R:R:R73	2.38	No	No	0	9	7
58	R:R:L148	R:R:R73	9.72	No	No	0	5	7
59	R:R:D153	R:R:R73	13.1	No	No	0	7	7
60	R:R:F76	R:R:F77	8.57	No	Yes	3	5	8
61	R:R:F76	R:R:H80	7.92	No	No	0	5	9
62	R:R:D153	R:R:F76	11.94	No	No	3	7	5
63	R:R:F77	R:R:M133	3.73	Yes	No	0	8	8
64	R:R:D136	R:R:F77	8.36	No	Yes	0	9	8
65	R:R:D153	R:R:F77	10.75	No	Yes	3	7	8
66	R:R:H80	R:R:V157	8.3	No	No	0	9	7
67	R:R:L130	R:R:L81	4.15	No	No	0	8	9
68	R:R:A84	R:R:L129	3.15	No	No	0	8	8
69	R:R:D85	R:R:S322	10.31	No	No	0	9	9
70	R:R:Q92	R:R:V88	2.87	Yes	No	0	7	7
71	R:R:S126	R:R:V88	3.23	No	No	0	9	7
72	R:R:F91	R:R:V90	7.87	No	No	0	5	5
73	R:R:F91	R:R:L118	6.09	No	No	0	5	5
74	R:R:Q119	R:R:Q92	3.84	Yes	Yes	1	7	7
75	R:R:M123	R:R:Q92	2.72	No	Yes	0	6	7
76	R:R:Q96	R:R:W99	2.19	Yes	Yes	1	7	5
77	R:R:D100	R:R:Q96	3.92	No	Yes	0	5	7
78	R:R:Q119	R:R:Q96	2.56	Yes	Yes	1	7	7
79	R:R:F105	R:R:W99	2	No	Yes	0	7	5
80	R:R:K116	R:R:W99	5.8	Yes	Yes	1	4	5
81	R:R:D186	R:R:W99	11.17	No	Yes	1	4	5
82	R:R:C187	R:R:W99	5.22	No	Yes	1	9	5
83	R:R:T102	R:R:Y106	3.75	No	No	0	6	3
84	R:R:F103	R:R:R104	7.48	No	No	0	4	5
85	R:R:R104	R:R:V184	6.54	No	No	0	5	3
86	R:R:D186	R:R:R104	8.34	No	No	0	4	5
87	R:R:G107	R:R:P108	4.06	No	No	0	6	7
88	R:R:L111	R:R:P108	3.28	No	No	0	5	7
89	R:R:D109	R:R:R113	13.1	No	No	0	4	6
90	R:R:D109	R:R:L177	8.14	No	No	0	4	4
91	R:R:L110	R:R:L114	2.77	No	No	0	3	5
92	R:R:C112	R:R:K116	3.23	No	Yes	0	9	4
93	R:R:C112	R:R:C187	7.28	No	No	0	9	9
94	R:R:R113	R:R:S176	5.27	No	No	0	6	5
95	R:R:Q119	R:R:V115	5.73	Yes	No	0	7	6
96	R:R:K116	R:R:Q119	4.07	Yes	Yes	1	4	7
97	R:R:K116	R:R:Q171	8.14	Yes	Yes	1	4	6
98	R:R:F175	R:R:K116	13.65	No	Yes	1	6	4
99	R:R:V121	R:R:Y117	3.79	Yes	No	1	6	7
100	R:R:L165	R:R:Y117	4.69	No	No	1	3	7
101	R:R:F124	R:R:V120	2.62	Yes	No	1	6	5
102	R:R:S168	R:R:V120	6.46	No	No	1	7	5
103	R:R:Q171	R:R:V120	5.73	Yes	No	1	6	5
104	R:R:G122	R:R:V121	3.68	No	Yes	0	6	6
105	R:R:L165	R:R:V121	4.47	No	Yes	1	3	6
106	R:R:S168	R:R:V121	4.85	No	Yes	1	7	6
107	R:R:C164	R:R:F124	2.79	No	Yes	0	8	6
108	R:R:F124	R:R:S168	3.96	Yes	No	1	6	7
109	R:R:F124	R:R:W203	2	Yes	No	1	6	4
110	R:R:F124	R:R:V208	5.24	Yes	No	0	6	5
111	R:R:A125	R:R:W161	5.19	No	No	0	7	9
112	R:R:A125	R:R:C164	3.61	No	No	0	7	8
113	R:R:T127	R:R:Y128	3.75	No	No	0	8	6
114	R:R:P212	R:R:T127	3.5	No	No	0	9	8
115	R:R:T127	R:R:W288	3.64	No	Yes	0	8	8
116	R:R:L131	R:R:Y128	2.34	No	No	0	7	6
117	R:R:L129	R:R:T160	2.95	No	No	0	8	7
118	R:R:L130	R:R:Y329	4.69	No	Yes	0	8	9
119	R:R:L131	R:R:V215	2.98	No	No	0	7	6
120	R:R:L132	R:R:T160	2.95	No	No	0	7	7
121	R:R:M133	R:R:Y329	8.38	No	Yes	0	8	9
122	R:R:L216	R:R:S134	3	No	No	0	8	8
123	R:R:C219	R:R:S134	5.16	No	No	0	6	8
124	R:R:S134	R:R:Y220	6.36	No	Yes	0	8	9
125	R:R:R137	R:R:Y220	2.06	No	Yes	0	9	9
126	R:R:R137	R:R:Y329	2.06	No	Yes	0	9	9
127	R:R:C138	R:R:C219	3.64	No	No	0	7	6
128	R:R:C138	R:R:L222	3.17	No	No	0	7	6
129	R:R:C138	R:R:I223	4.91	No	No	0	7	8
130	R:R:I141	R:R:I223	4.42	No	No	0	8	8
131	R:R:P144	R:R:Q143	6.32	No	No	0	9	5
132	R:R:Q143	R:R:R146	11.68	No	No	0	5	5
133	R:R:L145	R:R:P144	3.28	No	No	0	7	9
134	R:R:L148	R:R:T152	2.95	No	No	0	5	7
135	R:R:R149	R:R:R151	3.2	No	No	0	4	5
136	R:R:L155	R:R:R151	2.43	No	No	0	3	5
137	R:R:L158	R:R:R154	4.86	No	No	0	3	3
138	R:R:V157	R:R:W161	2.45	No	No	0	7	9
139	R:R:A169	R:R:P170	3.74	No	No	0	4	7
140	R:R:F175	R:R:Q171	8.2	No	Yes	1	6	6
141	R:R:Q171	R:R:Y200	4.51	Yes	Yes	1	6	7
142	R:R:H173	R:R:I174	2.65	No	No	0	5	5
143	R:R:F191	R:R:I174	5.02	Yes	No	1	6	5
144	R:R:I174	R:R:Y200	4.84	No	Yes	1	5	7
145	R:R:A189	R:R:F175	6.93	No	No	0	5	6
146	R:R:R178	R:R:S176	6.59	No	No	0	3	5
147	R:R:R178	R:R:W188	3	No	No	0	3	3
148	R:R:R178	R:R:V190	9.15	No	No	0	3	4
149	R:R:E179	R:R:F185	17.49	No	No	0	3	3
150	R:R:V180	R:R:W188	4.9	No	No	0	3	3
151	R:R:A181	R:R:D182	3.09	No	No	0	3	3
152	R:R:C187	R:R:D186	3.11	No	No	1	9	4
153	R:R:A189	R:R:F191	2.77	No	Yes	0	5	6
154	R:R:F191	R:R:G196	3.01	Yes	No	1	6	4
155	R:R:F191	R:R:P197	10.11	Yes	No	1	6	5
156	R:R:F191	R:R:Y200	4.13	Yes	Yes	1	6	7
157	R:R:I192	R:R:P194	3.39	No	No	0	4	4
158	R:R:P194	R:R:Q193	4.74	No	No	0	4	4
159	R:R:P194	R:R:W195	8.11	No	No	0	4	2
160	R:R:K198	R:R:W195	3.48	No	No	0	4	2
161	R:R:G196	R:R:P197	4.06	No	No	1	4	5
162	R:R:K198	R:R:W300	4.64	No	No	0	4	5
163	R:R:W203	R:R:Y200	2.89	No	Yes	1	4	7
164	R:R:I204	R:R:Y200	10.88	No	Yes	1	5	7
165	R:R:I201	R:R:Q295	2.74	Yes	No	0	5	6
166	R:R:I201	R:R:M296	5.83	Yes	No	0	5	6
167	R:R:I201	R:R:V299	4.61	Yes	No	0	5	4
168	R:R:L206	R:R:T202	2.95	No	No	0	5	5
169	R:R:T202	R:R:W300	3.64	No	No	0	5	5
170	R:R:I204	R:R:W203	2.35	No	No	1	5	4
171	R:R:F292	R:R:T205	7.78	No	No	0	7	5
172	R:R:M296	R:R:T205	4.52	No	No	0	6	5
173	R:R:I210	R:R:Y209	6.04	No	Yes	0	5	8
174	R:R:I285	R:R:Y209	2.42	No	Yes	0	6	8
175	R:R:W288	R:R:Y209	4.82	Yes	Yes	0	8	8
176	R:R:T289	R:R:Y209	6.24	No	Yes	0	6	8
177	R:R:P212	R:R:V211	3.53	No	No	0	9	5
178	R:R:F284	R:R:V213	3.93	No	No	0	9	6
179	R:R:I285	R:R:V213	3.07	No	No	0	6	6
180	R:R:T277	R:R:Y220	6.24	No	Yes	0	8	9
181	R:R:I280	R:R:Y220	8.46	No	Yes	0	8	9
182	R:R:S224	R:R:T273	9.59	No	No	0	5	8
183	R:R:F225	R:R:Q229	8.2	No	No	0	4	5
184	R:R:K226	R:R:Q229	8.14	No	No	0	6	5
185	R:R:K270	R:R:W228	15.08	No	No	0	8	6
186	R:R:T273	R:R:W228	2.43	No	No	0	8	6
187	R:R:L231	R:R:N230	4.12	No	No	0	5	7
188	R:R:I266	R:R:L231	4.28	No	No	0	6	5
189	R:R:I266	R:R:T235	3.04	No	No	0	6	3
190	R:R:A269	R:R:K268	6.42	No	No	0	6	6
191	R:R:M276	R:R:R272	2.48	No	No	0	8	8
192	R:R:F278	R:R:V274	3.93	No	No	0	6	7
193	R:R:I280	R:R:M276	2.92	No	No	0	8	8
194	R:R:F332	R:R:M276	13.68	No	No	0	7	8
195	R:R:I279	R:R:I328	2.94	No	No	5	7	8
196	R:R:F332	R:R:I279	6.28	No	No	5	7	7
197	R:R:I285	R:R:V281	3.07	No	No	0	6	8
198	R:R:F284	R:R:W288	9.02	No	Yes	4	9	8
199	R:R:F284	R:R:N321	4.83	No	No	4	9	9
200	R:R:C287	R:R:L320	3.17	No	No	0	8	5
201	R:R:C287	R:R:N321	6.3	No	No	0	8	9
202	R:R:F292	R:R:W288	6.01	No	Yes	0	7	8
203	R:R:N321	R:R:W288	12.43	No	Yes	4	9	8
204	R:R:P290	R:R:T289	5.25	No	No	0	9	6
205	R:R:F291	R:R:F292	5.36	Yes	No	0	7	7
206	R:R:F291	R:R:Q295	9.37	Yes	No	0	7	6
207	R:R:A318	R:R:F291	2.77	No	Yes	1	7	7
208	R:R:V294	R:R:V314	4.81	No	No	0	5	5
209	R:R:M296	R:R:W300	6.98	No	No	0	6	5
210	R:R:D301	R:R:W297	8.93	No	No	0	4	4
211	R:R:P305	R:R:W297	5.4	Yes	No	6	4	4
212	R:R:F311	R:R:W297	8.02	No	No	6	4	4
213	R:R:K306	R:R:S298	7.65	No	No	0	4	5
214	R:R:F311	R:R:S298	5.28	No	No	0	4	5
215	R:R:F311	R:R:P305	4.33	No	Yes	6	4	4
216	R:R:L317	R:R:L320	4.15	No	No	0	7	5
217	R:R:S319	R:R:S322	3.26	No	No	0	7	9
218	R:R:C324	R:R:I328	3.27	No	No	0	6	8
219	R:R:N325	R:R:Y329	2.33	No	Yes	0	9	9
220	R:R:F337	R:R:W327	3.01	No	No	0	8	6
221	R:R:F332	R:R:I328	2.51	No	No	5	7	8
222	R:R:F337	R:R:M330	7.46	No	No	0	8	7
223	R:R:F337	R:R:L331	9.74	No	No	0	8	5
224	R:R:L336	R:R:T333	5.9	No	No	0	8	8
225	R:R:H338	R:R:Q342	16.07	No	No	0	5	5
226	R:R:E339	R:R:Q342	2.55	No	No	0	6	5
227	R:R:P31	R:R:P32	1.95	No	No	0	4	3
228	R:R:A304	R:R:P305	1.87	No	Yes	0	3	4
229	R:R:A308	R:R:P305	1.87	No	Yes	0	2	4
230	R:R:A53	R:R:C323	1.81	No	Yes	0	8	7
231	R:R:A283	R:R:C324	1.81	No	No	0	6	6
232	R:R:A53	R:R:A89	1.79	No	No	0	8	7
233	R:R:P326	R:R:V60	1.77	No	No	0	9	9
234	R:R:P95	R:R:V115	1.77	No	No	0	4	6
235	R:R:C323	R:R:S322	1.72	Yes	No	0	7	9
236	R:R:G163	R:R:L162	1.71	No	No	0	4	4
237	R:R:A181	R:R:V180	1.7	No	No	0	3	3
238	R:R:C164	R:R:T160	1.69	No	No	0	8	7
239	L:L:L8	R:R:P32	1.64	No	No	0	0	3
240	R:R:C323	R:R:I49	1.64	Yes	No	0	7	7
241	R:R:L94	R:R:P95	1.64	No	No	0	8	4
242	R:R:E179	R:R:G183	1.64	No	No	0	3	4
243	R:R:N325	R:R:P326	1.63	No	No	0	9	9
244	R:R:S319	R:R:V93	1.62	No	No	0	7	7
245	R:R:S224	R:R:V274	1.62	No	No	0	5	7
246	R:R:A63	R:R:M330	1.61	No	No	0	7	7
247	R:R:A199	R:R:K198	1.61	No	No	0	4	4
248	R:R:S224	R:R:T277	1.6	No	No	0	5	8
249	R:R:C323	R:R:L52	1.59	Yes	No	0	7	5
250	R:R:C219	R:R:L135	1.59	No	No	0	6	6
251	R:R:G334	R:R:H335	1.59	No	No	0	5	6
252	R:R:A37	R:R:L38	1.58	No	Yes	0	3	5
253	R:R:A156	R:R:L132	1.58	No	No	0	5	7
254	R:R:T66	R:R:T67	1.57	No	No	0	6	6
255	R:R:I83	R:R:S82	1.55	No	No	0	6	9
256	R:R:I266	R:R:S267	1.55	No	No	0	6	4
257	R:R:A140	R:R:D136	1.54	No	No	0	8	9
258	R:R:M78	R:R:V60	1.52	No	No	0	7	9
259	R:R:L38	R:R:S309	1.5	Yes	No	0	5	2
260	R:R:L74	R:R:S72	1.5	No	No	0	8	8
261	R:R:L97	R:R:V43	1.49	No	No	0	7	6
262	R:R:L54	R:R:V90	1.49	No	No	0	6	5
263	R:R:N57	R:R:S82	1.49	Yes	No	0	9	9
264	R:R:L162	R:R:V166	1.49	No	No	0	4	3
265	R:R:L317	R:R:V314	1.49	No	No	0	7	5
266	R:R:L62	R:R:T66	1.47	Yes	No	0	4	6
267	R:R:L336	R:R:T67	1.47	No	No	0	8	6
268	R:R:I210	R:R:I214	1.47	No	No	0	5	3
269	R:R:I223	R:R:I227	1.47	No	No	0	8	8
270	R:R:I271	R:R:K275	1.45	No	No	0	6	8
271	L:L:Q4	R:R:S298	1.44	No	No	0	0	5
272	R:R:E42	R:R:V41	1.43	Yes	No	0	5	5
273	R:R:I227	R:R:L231	1.43	No	No	0	8	5
274	R:R:G56	R:R:W327	1.41	No	No	0	8	6
275	R:R:K79	R:R:L61	1.41	No	No	0	6	7
276	R:R:K79	R:R:L64	1.41	No	No	0	6	7
277	R:R:K70	R:R:L336	1.41	No	No	0	8	8
278	R:R:L74	R:R:M78	1.41	No	No	0	8	7
279	R:R:A167	R:R:F124	1.39	No	Yes	0	5	6
280	R:R:F91	R:R:V87	1.31	No	No	0	5	6
281	R:R:R151	R:R:T152	1.29	No	No	0	5	7
282	R:R:V172	R:R:Y117	1.26	No	No	0	5	7
283	R:R:F278	R:R:K275	1.24	No	No	0	6	8
284	R:R:T102	R:R:W99	1.21	No	Yes	0	6	5
285	R:R:L148	R:R:R146	1.21	No	No	0	5	5
286	R:R:F75	R:R:H71	1.13	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	4.87714	7	1	0
2	L:L:I3	4.0225	4	1	0
3	L:L:?10	5.4525	4	2	0
4	R:R:L38	5.7425	4	2	5
5	R:R:E42	3.335	4	0	5
6	R:R:N57	6.735	4	0	9
7	R:R:L62	5.66	4	0	4
8	R:R:F77	7.8525	4	3	8
9	R:R:Q92	4.0475	4	1	7
10	R:R:Q96	5.064	5	1	7
11	R:R:W99	4.59833	6	1	5
12	R:R:K116	6.978	5	1	4
13	R:R:Q119	4.142	5	1	7
14	R:R:V121	4.1975	4	1	6
15	R:R:F124	3	6	1	6
16	R:R:Q171	6.645	4	1	6
17	R:R:F191	5.008	5	1	6
18	R:R:Y200	5.34833	6	1	7
19	R:R:I201	4.03	4	0	5
20	R:R:Y209	4.88	4	0	8
21	R:R:Y220	5.78	4	0	9
22	R:R:W288	7.184	5	4	8
23	R:R:F291	4.89	4	1	7
24	R:R:P305	3.3675	4	6	4
25	R:R:C323	1.69	4	0	7
26	R:R:Y329	4.365	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I3	L:L:Y2	44.2624	2.42	Yes	Yes	1	0	0
2	L:L:Y2	R:R:F291	31.9821	2.06	Yes	Yes	1	0	7
3	L:L:I3	R:R:Y200	39.3315	4.84	Yes	Yes	1	0	7
4	L:L:I3	R:R:I201	35.0395	2.94	Yes	Yes	0	0	5
5	L:L:I3	R:R:I204	35.8264	5.89	Yes	No	1	0	5
6	L:L:Q4	R:R:Q295	12.2694	7.68	No	No	0	0	6
7	R:R:I201	R:R:V299	10.9916	4.61	Yes	No	0	5	4
8	R:R:Q96	R:R:W99	11.8435	2.19	Yes	Yes	1	7	5
9	R:R:D186	R:R:W99	21.68	11.17	No	Yes	1	4	5
10	R:R:D186	R:R:R104	21.1746	8.34	No	No	0	4	5
11	R:R:F103	R:R:R104	19.6369	7.48	No	No	0	4	5
12	L:L:L8	R:R:F103	12.3525	2.44	No	No	0	0	4
13	L:L:L8	R:R:P32	11.5655	1.64	No	No	0	0	3
14	R:R:P31	R:R:P32	10.775	1.95	No	No	0	4	3
15	R:R:D100	R:R:Q96	13.6231	3.92	No	Yes	0	5	7
16	R:R:D100	R:R:E42	11.3706	5.2	No	Yes	0	5	5
17	R:R:W203	R:R:Y200	38.8081	2.89	No	Yes	1	4	7
18	R:R:F124	R:R:W203	74.4252	2	Yes	No	1	6	4
19	R:R:C164	R:R:F124	100	2.79	No	Yes	0	8	6
20	R:R:A125	R:R:C164	97.6212	3.61	No	No	0	7	8
21	R:R:A125	R:R:W161	97.1916	5.19	No	No	0	7	9
22	R:R:V157	R:R:W161	96.7549	2.45	No	No	0	7	9
23	R:R:H80	R:R:V157	96.2856	8.3	No	No	0	9	7
24	R:R:F76	R:R:H80	95.8344	7.92	No	No	0	5	9
25	R:R:F76	R:R:F77	85.9438	8.57	No	Yes	3	5	8
26	R:R:F77	R:R:M133	91.741	3.73	Yes	No	0	8	8
27	R:R:M133	R:R:Y329	91.1309	8.38	No	Yes	0	8	9
28	R:R:N325	R:R:Y329	64.9713	2.33	No	Yes	0	9	9
29	R:R:N325	R:R:P326	64.1014	1.63	No	No	0	9	9
30	R:R:N57	R:R:P326	39.1979	6.52	Yes	No	0	9	9
31	R:R:D85	R:R:N57	24.6869	14.81	No	Yes	0	9	9
32	R:R:D85	R:R:S322	23.5209	10.31	No	No	0	9	9
33	R:R:S319	R:R:S322	15.1572	3.26	No	No	0	7	9
34	R:R:S319	R:R:V93	13.9335	1.62	No	No	0	7	7
35	R:R:I204	R:R:W203	35.9095	2.35	No	No	1	5	4
36	R:R:P326	R:R:V60	28.2966	1.77	No	No	0	9	9
37	R:R:M330	R:R:V60	23.8061	3.04	No	No	0	7	9
38	R:R:A63	R:R:M330	16.9621	1.61	No	No	0	7	7
39	R:R:A63	R:R:L340	15.807	6.3	No	No	0	7	8
40	R:R:N57	R:R:S82	14.7385	1.49	Yes	No	0	9	9
41	R:R:L61	R:R:S82	12.3849	6.01	No	No	0	7	9
42	R:R:L340	R:R:L62	13.4823	4.15	No	Yes	0	8	4
43	R:R:K79	R:R:L61	11.2154	1.41	No	No	0	6	7
44	R:R:K79	R:R:L64	10.0531	1.41	No	No	0	6	7
45	R:R:D153	R:R:R73	12.1178	13.1	No	No	0	7	7
46	R:R:L148	R:R:R73	14.1357	9.72	No	No	0	5	7
47	R:R:K116	R:R:Q119	10.1397	4.07	Yes	Yes	1	4	7
48	R:R:K116	R:R:W99	20.7811	5.8	Yes	Yes	1	4	5
49	R:R:K116	R:R:Q171	28.9391	8.14	Yes	Yes	1	4	6
50	R:R:Q171	R:R:V120	30.5851	5.73	Yes	No	1	6	5
51	R:R:F291	R:R:F292	30.1989	5.36	Yes	No	0	7	7
52	R:R:F292	R:R:W288	29.6971	6.01	No	Yes	0	7	8
53	R:R:R137	R:R:Y329	38.642	2.06	No	Yes	0	9	9
54	R:R:R137	R:R:Y220	37.5735	2.06	No	Yes	0	9	9
55	R:R:S134	R:R:Y220	17.4024	6.36	No	Yes	0	8	9
56	R:R:C219	R:R:S134	14.9912	5.16	No	No	0	6	8
57	R:R:C138	R:R:C219	12.551	3.64	No	No	0	7	6
58	R:R:C138	R:R:I223	10.0819	4.91	No	No	0	7	8
59	R:R:I201	R:R:M296	14.3234	5.83	Yes	No	0	5	6
60	R:R:M296	R:R:W300	12.634	6.98	No	No	0	6	5
61	R:R:T277	R:R:Y220	11.3165	6.24	No	Yes	0	8	9
62	R:R:I280	R:R:Y220	10.0639	8.46	No	Yes	0	8	9
63	R:R:S224	R:R:T277	10.0711	1.6	No	No	0	5	8
64	L:L:Q4	R:R:S298	19.395	1.44	No	No	0	0	5
65	R:R:F311	R:R:S298	14.5941	5.28	No	No	0	4	5
66	L:L:Y2	R:R:Q96	13.9407	9.02	Yes	Yes	1	0	7
67	R:R:F124	R:R:V120	26.8743	2.62	Yes	No	1	6	5
68	R:R:I201	R:R:Q295	10.8652	2.74	Yes	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C1	R:R:Q96	7.63	1	No	Yes	0	7	0	1
L:L:Y2	R:R:Q92	6.76	1	Yes	Yes	0	7	0	1
L:L:Y2	R:R:Q96	9.02	1	Yes	Yes	0	7	0	1
L:L:Y2	R:R:Q119	4.51	1	Yes	Yes	0	7	0	1
L:L:Y2	R:R:F291	2.06	1	Yes	Yes	0	7	0	1
L:L:Y2	R:R:A318	5.34	1	Yes	No	0	7	0	1
L:L:I3	R:R:Y200	4.84	1	Yes	Yes	0	7	0	1
L:L:I3	R:R:I201	2.94	1	Yes	Yes	0	5	0	1
L:L:I3	R:R:I204	5.89	1	Yes	No	0	5	0	1
L:L:Q4	R:R:Q295	7.68	0	No	No	0	6	0	1
L:L:Q4	R:R:V299	5.73	0	No	No	0	4	0	1
L:L:N5	R:R:W188	15.82	0	No	No	0	3	0	1
L:L:C6	R:R:M315	3.24	1	No	No	0	6	0	1
L:L:P7	R:R:I312	3.39	1	No	No	0	4	0	1
L:L:P7	R:R:M315	6.71	1	No	No	0	6	0	1
L:L:L8	R:R:F103	2.44	0	No	No	0	4	0	1
L:L:?10	R:R:N35	3.4	2	Yes	No	0	5	0	1
L:L:?10	R:R:L38	10.28	2	Yes	Yes	0	5	0	1
L:L:?10	R:R:A39	3.9	2	Yes	No	0	5	0	1
R:R:A39	R:R:R34	6.91	0	No	No	5	5	1	2
R:R:F103	R:R:R34	11.76	0	No	No	4	5	1	2
R:R:L38	R:R:N35	9.61	2	Yes	No	5	5	1	1
R:R:D100	R:R:E42	5.2	0	No	Yes	5	5	2	2
R:R:E42	R:R:I312	2.73	0	Yes	No	5	4	2	1
R:R:Q92	R:R:V88	2.87	1	Yes	No	7	7	1	2
R:R:Q119	R:R:Q92	3.84	1	Yes	Yes	7	7	1	1
R:R:M123	R:R:Q92	2.72	0	No	Yes	6	7	2	1
R:R:Q96	R:R:W99	2.19	1	Yes	Yes	7	5	1	2
R:R:D100	R:R:Q96	3.92	0	No	Yes	5	7	2	1
R:R:Q119	R:R:Q96	2.56	1	Yes	Yes	7	7	1	1
R:R:K116	R:R:W99	5.8	1	Yes	Yes	4	5	2	2
R:R:F103	R:R:R104	7.48	0	No	No	4	5	1	2
R:R:Q119	R:R:V115	5.73	1	Yes	No	7	6	1	2
R:R:K116	R:R:Q119	4.07	1	Yes	Yes	4	7	2	1
R:R:K116	R:R:Q171	8.14	1	Yes	Yes	4	6	2	2
R:R:Q171	R:R:Y200	4.51	1	Yes	Yes	6	7	2	1
R:R:F191	R:R:I174	5.02	1	Yes	No	6	5	2	2
R:R:I174	R:R:Y200	4.84	1	No	Yes	5	7	2	1
R:R:R178	R:R:W188	3	0	No	No	3	3	2	1
R:R:V180	R:R:W188	4.9	0	No	No	3	3	2	1
R:R:F191	R:R:Y200	4.13	1	Yes	Yes	6	7	2	1
R:R:W203	R:R:Y200	2.89	1	No	Yes	4	7	2	1
R:R:I204	R:R:Y200	10.88	1	No	Yes	5	7	1	1
R:R:I201	R:R:Q295	2.74	0	Yes	No	5	6	1	1
R:R:I201	R:R:M296	5.83	0	Yes	No	5	6	1	2
R:R:I201	R:R:V299	4.61	0	Yes	No	5	4	1	1
R:R:I204	R:R:W203	2.35	1	No	No	5	4	1	2
R:R:F291	R:R:F292	5.36	1	Yes	No	7	7	1	2
R:R:F291	R:R:Q295	9.37	1	Yes	No	7	6	1	1
R:R:A318	R:R:F291	2.77	1	No	Yes	7	7	1	1
R:R:K306	R:R:S298	7.65	0	No	No	4	5	2	1
R:R:F311	R:R:S298	5.28	6	No	No	4	5	2	1
R:R:P31	R:R:P32	1.95	0	No	No	4	3	2	1
L:L:L8	R:R:P32	1.64	0	No	No	0	3	0	1
R:R:A37	R:R:L38	1.58	0	No	Yes	3	5	2	1
R:R:L38	R:R:S309	1.5	2	Yes	No	5	2	1	2
L:L:Q4	R:R:S298	1.44	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RYC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2
Number of Linked Nodes	267
Number of Links	286
Number of Hubs	26
Number of Links mediated by Hubs	101
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	45934
Length Of Smallest Path	3
Average Path Length	17.9366
Length of Longest Path	41
Minimum Path Strength	1.345
Average Path Strength	4.87303
Maximum Path Strength	12.56
Minimum Path Correlation	0.7
Average Path Correlation	0.926211
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	41.7244
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.0625
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • neurohypophyseal hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • vasopressin receptor binding • V1A vasopressin receptor binding • G protein-coupled receptor binding • oxytocin receptor binding • heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate
Gene Ontology	Biological Process	• heart process • multicellular organismal process • system process • regulation of biological process • regulation of heart contraction • regulation of system process • biological regulation • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • penile erection • copulation • positive regulation of reproductive process • developmental process • heart development • multicellular organism development • anatomical structure development • animal organ development • circulatory system development • system development • response to ketone • response to lipid • response to stimulus • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • learning or memory • nervous system process • cognition • memory • male mating behavior • drinking behavior • feeding behavior • multi-multicellular organism process • sperm ejaculation • insemination • multi-organism reproductive process • response to electrical stimulus • response to abiotic stimulus • maternal aggressive behavior • aggressive behavior • response to organophosphorus • response to nitrogen compound • response to purine-containing compound • response to cAMP • positive regulation of cell communication • trans-synaptic signaling • regulation of signaling • regulation of cellular process • signaling • modulation of chemical synaptic transmission • positive regulation of synaptic transmission • cell-cell signaling • cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular process • positive regulation of cellular process • positive regulation of signaling • response to ether • positive regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • positive regulation of cellular component organization • regulation of cellular component organization • regulation of developmental process • regulation of nervous system development • positive regulation of developmental process • cellular component organization • cellular component biogenesis • cellular component assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • regulation of multicellular organismal development • positive regulation of cellular component biogenesis • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • positive regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • positive regulation of synapse assembly • response to peptide hormone • female pregnancy • maternal behavior • parental behavior • response to activity • regulation of blood pressure • positive regulation of blood pressure • regulation of hindgut contraction • positive regulation of smooth muscle contraction • digestive system process • smooth muscle contraction • regulation of smooth muscle contraction • positive regulation of digestive system process • positive regulation of hindgut contraction • regulation of digestive system process • muscle contraction • muscle system process • regulation of muscle system process • hindgut contraction • digestion • regulation of muscle contraction • positive regulation of muscle contraction • positive regulation of uterine smooth muscle contraction • uterine smooth muscle contraction • regulation of uterine smooth muscle contraction • eating behavior • response to retinoic acid • regulation of body fluid levels • renal system process • regulation of urine volume • negative regulation of urine volume • response to carbohydrate • response to sucrose • response to disaccharide • cellular response to stimulus • signal transduction • response to corticosteroid • response to glucocorticoid • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • response to prostaglandin • response to alcohol • response to prostaglandin E • biological process involved in intraspecies interaction between organisms • social behavior • positive regulation of female receptivity • female mating behavior • regulation of female receptivity • ossification • positive regulation of ossification • regulation of ossification • response to amine • response to amphetamine • regulation of localization • localization • regulation of prostaglandin secretion • monocarboxylic acid transport • fatty acid transport • prostaglandin secretion • positive regulation of icosanoid secretion • carboxylic acid transport • lipid transport • establishment of localization • regulation of fatty acid transport • regulation of secretion • organic acid transport • positive regulation of lipid transport • lipid export from cell • prostaglandin transport • transport • regulation of lipid transport • positive regulation of secretion by cell • regulation of secretion by cell • secretion by cell • positive regulation of secretion • icosanoid transport • signal release • regulation of icosanoid secretion • positive regulation of prostaglandin secretion • icosanoid secretion • organic anion transport • regulation of transport • secretion • export from cell • lipid localization • positive regulation of lipid localization • positive regulation of organic acid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • grooming behavior • response to cocaine • response to alkaloid • response to nutrient levels • response to food • response to estradiol • negative regulation of blood pressure • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of amine transport • catecholamine transport • norepinephrine transport • positive regulation of catecholamine secretion • positive regulation of norepinephrine secretion • organic cation transport • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • extracellular space • axon • synapse • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse • cell projection • distal axon • terminal bouton • cell junction • neuron projection terminus • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • oxytocin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • binding • peptide hormone binding • hormone binding • vasopressin receptor activity • ionotropic glutamate receptor binding • protein binding • signaling receptor binding • glutamate receptor binding • response to stimulus • response to chemical • response to xenobiotic stimulus • multicellular organismal process • regulation of biological process • regulation of penile erection • regulation of reproductive process • reproductive process • multicellular organismal reproductive process • biological regulation • positive regulation of biological process • mating behavior • behavior • positive regulation of penile erection • positive regulation of multicellular organismal process • reproductive behavior • regulation of multicellular organismal process • penile erection • copulation • positive regulation of reproductive process • developmental process • heart development • multicellular organism development • anatomical structure development • animal organ development • circulatory system development • system development • ovulation cycle • rhythmic process • estrous cycle • regulation of tube diameter • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • response to ketone • response to lipid • response to hormone • response to steroid hormone • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • learning or memory • nervous system process • cognition • memory • multi-multicellular organism process • sperm ejaculation • insemination • multi-organism reproductive process • suckling behavior • feeding behavior • response to decreased oxygen levels • response to anoxia • response to stress • response to oxygen levels • response to abiotic stimulus • regulation of body fluid levels • secretion • transport • mammary gland development • gland development • establishment of localization • body fluid secretion • localization • lactation • muscle contraction • muscle system process • maternal process involved in parturition • parturition • positive regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of cellular process • positive regulation of cellular component organization • regulation of cellular component organization • regulation of developmental process • regulation of nervous system development • positive regulation of developmental process • cellular component organization • cellular component biogenesis • cellular component assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • positive regulation of cellular process • regulation of multicellular organismal development • positive regulation of cellular component biogenesis • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • positive regulation of cell junction assembly • regulation of synapse organization • cell junction organization • cellular process • synapse assembly • positive regulation of synapse assembly • response to peptide hormone • response to nitrogen compound • female pregnancy • positive regulation of cell communication • signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • cell communication • synaptic signaling • trans-synaptic signaling • regulation of signaling • positive regulation of synaptic transmission • cell-cell signaling • positive regulation of synaptic transmission, glutamatergic • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • cellular response to stimulus • intracellular signal transduction • intracellular signaling cassette • MAPK cascade • ERK1 and ERK2 cascade • signal transduction • positive regulation of synaptic transmission, GABAergic • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • maternal behavior • parental behavior • digestive system development • tube development • digestive tract development • regulation of blood pressure • positive regulation of blood pressure • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of muscle system process • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • eating behavior • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • cell surface receptor signaling pathway • head development • forebrain development • brain development • central nervous system development • telencephalon development • biological process involved in intraspecies interaction between organisms • social behavior • response to amine • response to amphetamine • G protein-coupled receptor signaling pathway • response to cocaine • response to alkaloid • response to estradiol • monoamine transport • regulation of localization • nitrogen compound transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • positive regulation of amine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • positive regulation of secretion • signal release • norepinephrine transport • regulation of transport • positive regulation of catecholamine secretion • export from cell • positive regulation of norepinephrine secretion • organic cation transport • regulation of secretion • catecholamine secretion • amine transport • positive regulation of transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • cell-cell junction • adherens junction • anchoring junction • actin-based cell projection • microvillus • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • G-protein beta-subunit binding • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of monoatomic ion transport • metal ion transport • calcium ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • regulation of ERK1 and ERK2 cascade • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • negative regulation of calcium ion-dependent exocytosis • regulation of vesicle-mediated transport • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • negative regulation of synaptic transmission • cellular response to nitrogen compound • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient levels • response to nutrient • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein localization • establishment of protein localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • fibroblast proliferation • midbody • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?10
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30559
Sequence	>7RYC_nogp_Chain_R P P R R N E A L A R V E V A V L C L I L L L A L S G N A C V L L A L R T T Q K H S R L F F F M K H L S I A D L V V A V F Q V L P Q L L W D I T F R F Y G P D L L C R L V K Y L Q V V G M F A S T Y L L L L M S L D R C L A I C Q P L R S L R R R T D R L A V L A T W L G C L V A S A P Q V H I F S L R E V A D G V F D C W A V F I Q P W G P K A Y I T W I T L A V Y I V P V I V L A A C Y G L I S F K I W Q N L R L K T A I S K A K I R T V K M T F I I V L A F I V C W T P F F F V Q M W S V W D A N A P K E A S A F I I V M L L A S L N S C C N P W I Y M L F T G H L F H E L V Q R F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	10.1101/2023.12.06.570395
	7QVM	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-	chim(NtGi1-Go-CtGq)/β1/γ2	3.25	2022-08-10	10.1038/s41467-022-31325-0
	7QVM (No Gprot)	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-		3.25	2022-08-10	10.1038/s41467-022-31325-0
	7RYC	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.9	2022-03-09	10.1038/s41594-022-00728-4
	7RYC (No Gprot)	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Oxytocin	-		2.9	2022-03-09	10.1038/s41594-022-00728-4
	6TPK	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Retosiban	-	-	3.2	2020-08-05	10.1126/sciadv.abb5419
	6TOT	A	Peptide	Orexin	OX₁	Homo sapiens	Lemborexant	-	-	2.22	2020-01-15	10.1021/acs.jmedchem.9b01787
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/β1/γ2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6OT0 (No Gprot)	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol		3.84	2019-06-12	10.1038/s41586-019-1286-0

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