Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1S:S:Q27 3.934225
2S:S:Y35 6.6675415
3S:S:F41 5.994558
4S:S:F65 6.165404
5S:S:N68 5.4454
6S:S:W72 7.58875855
7S:S:M76 4.8475458
8S:S:K77 7.1825405
9S:S:L89 4.184587
10S:S:Y97 10.815408
11S:S:L99 6.6975457
12S:S:F100 9.5125404
13S:S:M110 4.26405
14S:S:F116 5.89505
15S:S:L117 5.886514
16S:S:Y131 9.08413
17S:S:P144 7.7425405
18S:S:H145 8.52555
19S:S:F156 5.295614
20S:S:F157 6.34717
21S:S:F159 7.1775415
22S:S:F160 12.6415
23S:S:M162 3.68286716
24S:S:P163 4.4417
25S:S:Q164 6.526517
26S:S:Y167 8.2125457
27S:S:L174 7.142518
28S:S:F180 5.684516
29S:S:F183 7.16667618
30S:S:F184 9.754116
31S:S:D190 7.93254198
32S:S:F204 8.23638
33S:S:W206 12.7439
34S:S:W208 5.463336269
35S:S:E217 5.57254125
36S:S:Y218 8.28754198
37S:S:R220 4.574125
38S:S:R233 4.24404
39S:S:I237 5.65405
40S:S:E240 7.925405
41S:S:L242 4.9425403
42S:S:V268 3.78754267
43S:S:F274 8.623336197
44S:S:Y286 7.1325406
45S:S:W303 7.56429707
46S:S:L312 3.945402
47S:S:F324 6.8425436
48S:S:L331 6.84486
49S:S:F334 6.4487
50S:S:Q389 6.888554
51S:S:T390 5.9125485
52S:S:Y394 10.1475488
53S:S:Y398 8.7575488
54S:S:L404 7.0825417
55S:S:L408 4.35414
56S:S:C415 4.895418
57S:S:K422 7.805413
58S:S:P423 5.085416
59S:S:L433 4.1754116
60S:S:F435 7.784119
61S:S:F444 6.8785119
62S:S:V471 5.2925408
63S:S:R473 7.215443
64S:S:T480 4.9475436
65S:S:W487 6.21125838
66S:S:H488 6.5404
67S:S:P495 6.435437
68S:S:Q507 5.8785167
69S:S:Y529 7.13477
70S:S:Q531 8.07477
71S:S:C541 5.935479
72S:S:W546 11.7575407
73S:S:S547 4.33478
74S:S:C554 6.735479
75S:S:L562 3.74408
76S:S:L576 3.90754296
77S:S:L580 3.2954295
78S:S:F590 4.885139
79S:S:L598 4.0125407
80S:S:F609 4.35254326
81S:S:L611 6.35754139
82S:S:F624 6.06507
83S:S:Q637 5.3165348
84S:S:P643 5.55406
85S:S:Y699 6.022506
86S:S:F703 4.21405
87S:S:W711 4.2125403
88S:S:F730 5.272507
89S:S:C744 4.0125408
90S:S:F749 10.0625408
91S:S:R762 5.0125409
92S:S:L764 4.15254139
93S:S:Y771 8.0425408
94S:S:F778 5.5665339
95S:S:V779 2.825406
96S:S:L782 4.70254338
97S:S:M795 4.374507
98S:S:L803 2.0785306
99S:S:F809 8.2785138
100S:S:R813 6.8725409
101R:R:D26 7.51464
102R:R:Y33 4.53254215
103R:R:L38 4.468517
104R:R:F39 5.74568
105R:R:H42 5.7154357
106R:R:V64 4.935404
107R:R:Y69 7.4875407
108R:R:L71 4.4925465
109R:R:M72 4.66565
110R:R:M75 4.39568
111R:R:R76 10.465465
112R:R:F77 7.9475408
113R:R:E81 6.7075498
114R:R:Y96 7.13833668
115R:R:E97 5.832505
116R:R:I98 4.65467
117R:R:P110 5.316515
118R:R:F114 4.88516
119R:R:L115 5.784515
120R:R:H117 5.8075414
121R:R:L122 4.985414
122R:R:Y128 9.074514
123R:R:Y131 7.32167614
124R:R:P141 4.958516
125R:R:V147 7.1325418
126R:R:F153 5.02667614
127R:R:F157 8.085417
128R:R:Q161 5.25618
129R:R:I162 4.3785376
130R:R:Y164 5.992567
131R:R:R172 7.12667618
132R:R:F177 6.83615
133R:R:L180 5.496518
134R:R:L181 8.19754376
135R:R:R182 8.865419
136R:R:T183 3.5525409
137R:R:H189 8.0325414
138R:R:E192 7.318513
139R:R:F201 7.466676148
140R:R:W203 6.696149
141R:R:W205 8.586676389
142R:R:I207 6.65208
143R:R:Y215 6.71714727
144R:R:R217 5.333336126
145R:R:R226 6.218514
146R:R:R230 5.4075404
147R:R:F236 9.4165206
148R:R:K263 5.23403
149R:R:V271 6.65754148
150R:R:F275 6.034508
151R:R:S276 5.1725424
152R:R:P277 3.6275425
153R:R:F284 5.278504
154R:R:F285 5.352524
155R:R:E287 4.7745175
156R:R:F293 6.1775403
157R:R:W298 7.29286728
158R:R:E302 6.46428
159R:R:W304 5.98714727
160R:R:D307 9.08405
161R:R:H311 10.13404
162R:R:L316 5.1625424
163R:R:F322 8.35571727
164R:R:V330 6.855494
165R:R:I332 3.605406
166R:R:F373 5.6475405
167R:R:R383 54395
168R:R:V385 6.1575406
169R:R:Y386 6.395697
170R:R:Y389 7.334598
171R:R:Y393 9.7475498
172R:R:V395 3.5406
173R:R:C410 4.414365
174R:R:W418 8.5625233
175R:R:F429 9.298509
176R:R:L431 6.775497
177R:R:L432 4.4025494
178R:R:Q435 5.73413
179R:R:F437 5.7875414
180R:R:F438 5.644378
181R:R:Q441 8.3125417
182R:R:I450 3.7675408
183R:R:W453 7.8725425
184R:R:W455 8.63423
185R:R:P461 4.0575402
186R:R:Y468 6.84333615
187R:R:R473 6.81514
188R:R:I481 5.7985147
189R:R:W483 9.091676148
190R:R:H484 5.96404
191R:R:P491 5.926509
192R:R:K505 10.48754188
193R:R:E532 5.0385186
194R:R:Y533 7.4665183
195R:R:C538 6.06449
196R:R:W543 10.4275407
197R:R:C551 6.655449
198R:R:F558 5.464437
199R:R:F577 5.4925406
200R:R:H590 9.6575405
201R:R:T593 4.5775409
202R:R:I595 5.9125407
203R:R:M603 6.1125408
204R:R:V618 3.09254457
205R:R:Y621 14.08408
206R:R:F641 8.82754158
207R:R:I643 4.484477
208R:R:R651 5.6025109
209R:R:F665 11.5554485
210R:R:W672 6.894446
211R:R:P678 4.8485448
212R:R:K689 6.99509
213R:R:I715 6.01754424
214R:R:N721 4.3554466
215R:R:D735 6.724158
216R:R:A746 2.9554109
217R:R:N755 6.10254108
218R:R:E758 6.574109
219R:R:I762 4.28754109
220R:R:Y769 7.6585158
221R:R:V797 2.37254459
222R:R:N799 6.61754159
223R:R:Y807 7.5285108
224R:R:F808 7.9075409
225H:H:?901 14.39740
226H:H:?903 20.32254270
227H:H:?904 11.74710
228H:H:?905 18.125400
229H:H:?906 14.912510
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:C415 S:S:L408 10.07894.76YesYes184
2S:S:L404 S:S:L408 19.65634.15YesYes174
3S:S:L139 S:S:L404 16.82085.54NoYes147
4S:S:F100 S:S:R369 10.482119.24YesNo041
5S:S:V165 S:S:V400 78.92674.81NoNo076
6S:S:F100 S:S:F116 12.17755.36YesYes045
7S:S:A140 S:S:V400 81.63363.39NoNo086
8S:S:A140 S:S:P163 82.30153.74NoYes087
9S:S:M162 S:S:P163 67.42965.03YesYes167
10S:S:L117 S:S:M162 37.85734.24YesYes146
11S:S:F156 S:S:L117 35.27573.65YesYes144
12R:R:F153 S:S:F156 85.4875.36YesYes144
13R:R:F153 S:S:M110 21.83013.73YesYes045
14S:S:F157 S:S:M162 34.2393.73YesYes176
15S:S:F156 S:S:F157 48.39415.36YesYes147
16S:S:F116 S:S:V141 12.45035.24YesNo057
17S:S:F157 S:S:V141 11.803411.8YesNo177
18R:R:H189 R:R:P185 14.46594.58YesNo048
19R:R:D188 R:R:R473 20.955610.72NoYes134
20R:R:D188 R:R:R172 46.44333.57NoYes138
21R:R:Q441 R:R:R172 28.530512.85YesYes178
22R:R:D439 R:R:Q441 28.620810.44NoYes187
23R:R:D439 R:R:F437 28.56784.78NoYes184
24H:H:?904 R:R:F437 28.24077.65YesYes104
25R:R:L281 R:R:S276 80.99689.01NoYes244
26R:R:P277 R:R:S276 80.97163.56YesYes254
27R:R:P277 R:R:Y215 81.31694.17YesYes257
28R:R:I167 R:R:Y215 74.53314.84NoYes287
29R:R:A187 R:R:I167 75.05554.87NoNo088
30R:R:A187 R:R:D169 75.09563.09NoNo085
31R:R:D169 R:R:R172 81.37815.96NoYes058
32S:S:M110 S:S:V152 22.17894.56YesNo055
33R:R:F153 R:R:L115 22.04973.65YesYes145
34S:S:L426 S:S:P163 16.41234.93NoYes067
35R:R:N152 S:S:V152 22.22287.39NoNo055
36R:R:F177 R:R:N152 22.27944.83YesNo055
37R:R:F177 R:R:L171 25.19043.65YesNo157
38R:R:L171 R:R:R182 1004.86NoYes179
39R:R:R172 R:R:R182 99.59996.4YesYes189
40S:S:S399 S:S:V165 77.76663.23NoNo087
41S:S:F435 S:S:S399 69.58487.93YesNo1198
42S:S:F435 S:S:L442 66.98.53YesNo096
43S:S:L442 S:S:V450 66.22134.47NoNo063
44S:S:M452 S:S:V450 65.54263.04NoNo053
45S:S:M452 S:S:P188 60.76710.06NoNo2557
46S:S:P188 S:S:Y454 60.10949.74NoNo078
47S:S:Q193 S:S:Y454 58.75036.76NoNo098
48S:S:F274 S:S:Q193 49.87247.03YesNo1979
49S:S:V270 S:S:W206 18.692918.39NoYes099
50S:S:V209 S:S:V270 19.15866.41NoNo079
51S:S:L201 S:S:V209 19.62414.47NoNo067
52S:S:I235 S:S:L201 20.08964.28NoNo066
53S:S:A230 S:S:I235 22.88083.25NoNo066
54S:S:A230 S:S:I237 23.34573.25NoYes065
55S:S:E240 S:S:I237 26.13358.2YesYes055
56S:S:E240 S:S:F514 27.526312.83YesNo054
57R:R:Q237 S:S:F514 27.990410.54NoNo054
58R:R:Q237 R:R:V208 30.17615.73NoNo055
59R:R:I234 R:R:V208 17.34914.61NoNo065
60R:R:I234 R:R:V227 17.56113.07NoNo067
61R:R:I232 R:R:V227 17.99613.07NoNo077
62R:R:I232 R:R:L199 20.17774.28NoNo075
63R:R:L199 R:R:R230 20.39866.07NoYes054
64R:R:E192 R:R:R230 14.3855.82YesYes034
65R:R:E192 R:R:R226 12.55718.14YesYes134
66R:R:D188 R:R:R226 25.39828.34NoYes134
67R:R:V208 R:R:V273 13.23564.81NoNo057
68R:R:I299 R:R:V273 13.37797.68NoNo077
69R:R:I299 R:R:M194 12.79624.37NoNo077
70R:R:F275 R:R:M194 12.38076.22YesNo087
71R:R:F275 R:R:L223 12.38187.31YesNo086
72R:R:I191 R:R:L223 12.4764.28NoNo066
73R:R:E192 R:R:R473 13.6356.98YesYes134
74R:R:F285 R:R:L281 75.31523.65YesNo244
75R:R:F285 R:R:W298 74.29589.02YesYes248
76R:R:V272 R:R:W298 69.19417.36NoYes068
77R:R:I207 R:R:V272 69.12364.61YesNo086
78R:R:A269 R:R:I207 71.22423.25NoYes078
79R:R:A269 R:R:W205 71.15285.19NoYes079
80S:S:D216 S:S:Y218 10.93653.45NoYes068
81S:S:L273 S:S:W303 15.074112.53NoYes057
82S:S:S300 S:S:W303 39.64676.18NoYes087
83S:S:F274 S:S:S300 40.32795.28YesNo078
84S:S:L273 S:S:L283 10.96754.15NoNo055
85S:S:L283 S:S:V243 10.28265.96NoNo055
86S:S:F284 S:S:W303 17.810510.02NoYes047
87S:S:F284 S:S:M315 13.70539.95NoNo044
88R:R:C495 R:R:W205 66.868514.37NoYes3899
89R:R:C495 R:R:S496 67.63113.44NoNo098
90R:R:F515 R:R:S496 67.555715.85NoNo078
91R:R:F515 R:R:K505 67.480316.13NoYes078
92R:R:C499 R:R:K505 66.18513.23NoYes098
93R:R:C499 R:R:C517 66.10827.28NoNo099
94R:R:C517 R:R:Q503 66.03126.1NoNo096
95R:R:D519 R:R:Q503 65.87696.53NoNo046
96R:R:D519 R:R:Q546 65.72246.53NoNo041
97R:R:P522 R:R:Q546 65.6453.16NoNo051
98R:R:P522 R:R:W543 65.48996.76NoYes057
99R:R:P713 R:R:W543 63.12468.11NoYes047
100R:R:D712 R:R:P713 63.04454.83NoNo044
101R:R:D712 R:R:I715 62.64274.2NoYes044
102R:R:I715 R:R:V557 62.21474.61YesNo4245
103R:R:I717 R:R:V557 62.15793.07NoNo065
104R:R:I717 R:R:V786 61.17953.07NoNo068
105R:R:L787 R:R:V786 61.09742.98NoNo058
106R:R:L787 R:R:Y783 61.01533.52NoNo058
107R:R:F779 R:R:Y783 60.85077.22NoNo078
108R:R:F779 S:S:W727 60.685911.02NoNo073
109S:S:F730 S:S:W727 60.60336.01YesNo073
110S:S:F730 S:S:L782 25.80123.65YesYes078
111S:S:L782 S:S:Q794 17.55326.65YesNo3388
112S:S:F624 S:S:Q794 17.50793.51YesNo078
113S:S:F624 S:S:M795 15.88814.98YesYes077
114S:S:M795 S:S:V621 14.19853.04YesNo077
115S:S:L799 S:S:V621 14.09465.96NoNo087
116S:S:L576 S:S:L799 12.7325.54YesNo068
117S:S:C618 S:S:L576 12.11493.17NoYes2986
118S:S:C618 S:S:V802 12.0065.12NoNo088
119S:S:L614 S:S:V802 11.54662.98NoNo098
120S:S:F730 S:S:H734 38.725510.18YesNo077
121S:S:H734 S:S:W775 38.685217.98NoNo079
122S:S:W775 S:S:Y771 38.48118.33NoYes098
123S:S:F772 S:S:Y771 38.17035.16NoYes068
124S:S:F742 S:S:F772 37.96344.29NoNo036
125R:R:F768 S:S:F742 37.75613.22NoNo073
126R:R:A802 R:R:F768 15.5974.16NoNo077
127R:R:A802 R:R:S765 15.47841.71NoNo079
128R:R:G806 R:R:S765 15.35981.86NoNo069
129R:R:S772 R:R:Y769 11.01915.09NoYes1598
130R:R:L798 R:R:S772 11.13053NoNo1579
131R:R:F768 R:R:L798 22.6133.65NoNo077
132R:R:N799 R:R:Y769 11.03410.47YesYes1598
133R:R:L798 R:R:N799 11.36814.12NoYes1579
134R:R:V111 R:R:V150 22.1486.41NoNo067
135R:R:F153 R:R:V111 43.53175.24YesNo046
136R:R:Q161 R:R:V150 21.59348.6YesNo087
137R:R:L154 R:R:Q161 44.83693.99NoYes068
138R:R:L154 R:R:V111 21.54864.47NoNo066
139R:R:L115 R:R:L154 23.31324.15YesNo056
140R:R:L180 R:R:Q161 68.94916.65YesYes188
141R:R:L171 R:R:L180 74.81415.54NoYes178
142R:R:E192 R:R:Q196 13.07718.92YesNo036
143R:R:L475 R:R:Q196 12.86645.32NoNo016
144R:R:Q634 R:R:R633 10.51623.5NoNo088
145R:R:P638 R:R:Q634 12.69813.16NoNo058
146R:R:N731 R:R:P638 12.94026.52NoNo075
147R:R:D735 R:R:N731 15.11196.73YesNo087
148R:R:D735 R:R:Y769 17.11765.75YesYes1588
149R:R:L805 R:R:S804 10.14333NoNo028
150R:R:G806 R:R:L805 10.25471.71NoNo062
151R:R:C644 R:R:L611 10.00533.17NoNo079
152R:R:L611 R:R:S804 10.12413NoNo098
153S:S:L139 S:S:L426 16.76896.92NoNo046
154H:H:?904 S:S:P416 20.03155.89YesNo103
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9NOT
Class C
SubFamily Sensory
Type Taste1
SubType TAS1R2; TAS1R3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.8
Date 2025-04-09
D.O.I. doi.org/10.1016/j.cell.2025.04.021
Net Summary
Imin 3
Number of Linked Nodes 1459
Number of Links 1697
Number of Hubs 229
Number of Links mediated by Hubs 851
Number of Communities 48
Number of Nodes involved in Communities 324
Number of Links involved in Communities 435
Path Summary
Number Of Nodes in MetaPath 155
Number Of Links MetaPath 154
Number of Shortest Paths 4304488
Length Of Smallest Path 3
Average Path Length 43.7516
Length of Longest Path 98
Minimum Path Strength 1.01
Average Path Strength 6.17545
Maximum Path Strength 34.5
Minimum Path Correlation 0.72
Average Path Correlation 0.998688
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 59.4718
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.9883
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• sensory perception of sweet taste   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • response to stimulus   • detection of chemical stimulus involved in sensory perception of sweet taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • response to chemical   • detection of chemical stimulus   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • protein-containing complex   • receptor complex   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • taste receptor complex   • sweet taste receptor complex   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled receptor activity   • sensory perception of umami taste   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • Golgi apparatus   • organelle   • cytoplasm   • intracellular membrane-bounded organelle   • endomembrane system
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?901 H:H:?902 H:H:?903 H:H:?904 H:H:?905 H:H:?906 H:H:?907 H:H:?908
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainS
ProteinReceptor
UniProtQ7RTX0
Sequence
>9NOT_Chain_S
LCLSQQLRM KGDYVLGGL FPLGEARTR PSSPVCTRF SSNGLLWAL 
AMKMAVEEI NNKSDLLPG LRLGYDLFD TCSEPVVAM KPSLMFLAK 
AGSRDIAAY CNYTQYQPR VLAVIGPHS SELAMVTGK FFSFFLMPQ 
VSYGASMEL LSARETFPS FFRTVPSDR VQLTAAAEL LQEFGWNWV 
AALGSDDEY GRQGLSIFS ALAAARGIC IAHEGLVPL PKVQDVLHQ 
VNQSSVQVV LLFASVHAA HALFNYSIS SRLSPKVWV ASEAWLTSD 
LVMGLPGMA QMGTVLGFL QRGAQLHEF PQYVKTHLA LATDPAFCS 
ALQRCPQCD CITLQNVSA GLNHHQTFS VYAAVYSVA QALHNTLQC 
NASGCPAQD PVKPWQLLE NMYNLTFHV GGLPLRFDS SGNVDMEYD 
LKLWVWQGS VPRLHDVGR FNGSLRTER LKIRWHTSD NQKPVSRCS 
RQCQEGQVR RVKGFHSCC YDCVDCEAG SYRQNPDDI ACTFCGQDE 
WSPERSTRC FRRRSRFLA WGEPAVLLL LLLLSLALG LVLAALGLF 
VHHRDSPLV QASGGPLAC FGLVCLGLV CLSVLLFPG QPSPARCLA 
QQPLSHLPL TGCLSTLFL QAAEIFVES ELPLSWADR LSGCLRGPW 
AWLVVLLAM LVEVALCTW YLVAFPPEV VTDWHMLPT EALVHCRTR 
SWVSFGLAH ATNATLAFL CFLGTFLVR SQPGYNRAR GLTFAMLAY 
FITWVSFVP LLANVQVVL RPAVQMGAL LLCVLGILA AFHLPRCYL 
LMRQPGLNT R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TE23
Sequence
>9NOT_Chain_R
YFSFASCVC CLPCLVSDF YLPGDYLLG GLFSLHAMC KEYEVKVIG 
YNLMQAMRF AVEEINNDS SLLPGVLLG YEIVDVCYI SNNVQPVLY 
FLAHEDNLL PIQEDSNYI SRVVAVIGP DNSESVMTV ANFLSLLLP 
QITYSAISD ELRDKVRFP ALLRTTPSA DHHIEAMVQ LMLHFRWNW 
IIVLVSSDT YGRDNGQLL GERVARRDI CIAFQETLP TLQPNQNMT 
SEERQRLVT IVDKLQQST ARVVVVFPD LTLYHFNEV LRQNFTGAV 
WIASESWAI DPVLHNLTE LRHLGTFLG ITIQSVPIP GFSEFREWG 
TCNQECDNC LNATLSFNT ILRLSGERV VYSVYSAVY AVHALHSLL 
GCDKSTCTK RVVYPWQLL EEIWKVNFT LLDHQIFFD PQGDVALHL 
EIVQWQWDR SQNPFQVAS YYPLQRQLK NIQDISWHT INNTIPMSM 
CSKRQSGQK KKPGIHVCC FEIDCLPGT FLNHTEDEY ECQAPNNEW 
SYQSETSCF KRQLVFLEW HEAPTIAVA LLAALGFLS TLAILVIFW 
RHFQTPIVR SAGGPMCFL MLTLLVAYM VVPVYVGPP KVSTCLCRQ 
ALFLCFTIC ISIAVRSFQ IVCAFKMAS RFPRAYSYW VRYQGPYVS 
MAFITVLKM VIVVIGMLA TGLSPTTRT DPDDPKITI VSCNPNYRN 
SLLFNTSLD LLLSVVGFS FAYMGKELP TNYNEAKFI TSMTFYFTS 
SVSLCTFMS AYSGVLTIV DLLVTVLNL LAISLGYFG PKCYMILFY 
PE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9NOXCSensoryTaste1TAS1R2Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOX (No Gprot) CSensoryTaste1TAS1R2Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOYCSensoryTaste1TAS1R2Homo sapiens---3.72025-04-09doi.org/10.1016/j.cell.2025.04.021
9NORCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.42025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOSCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.52025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOTCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.82025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38 (No Gprot) CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9OQ0CSensoryTaste1TAS1R2; TAS1R3Homo sapiens; mus musculus---3.672025-08-27To be published
9UT8CSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.412025-07-16doi.org/10.1038/s41586-025-09302-6
9UTACSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.772025-07-16doi.org/10.1038/s41586-025-09302-6
9UTBCSensoryTaste1TAS1R2; TAS1R3Homo sapiensSucralose--3.592025-07-16doi.org/10.1038/s41586-025-09302-6




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