psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D519	R:R:Q546	14.36	No	No	0	4	1
2	R:R:C520	R:R:T524	6.76	No	No	12	9	7
3	R:R:C520	R:R:C535	7.28	No	No	12	9	9
4	R:R:L521	R:R:P522	6.57	No	No	0	5	5
5	R:R:P522	R:R:W543	5.4	No	Yes	0	5	7
6	R:R:G523	R:R:W543	11.26	No	Yes	0	7	7
7	R:R:C535	R:R:T524	3.38	No	No	12	9	7
8	R:R:F525	R:R:N527	7.25	Yes	Yes	0	7	8
9	R:R:F525	R:R:T529	3.89	Yes	No	0	7	6
10	R:R:C538	R:R:F525	11.17	Yes	Yes	4	9	7
11	R:R:F525	R:R:S544	5.28	Yes	No	4	7	8
12	R:R:C551	R:R:F525	9.78	Yes	Yes	4	9	7
13	R:R:H528	R:R:L526	3.86	No	No	0	4	8
14	R:R:L526	R:R:S547	4.5	No	No	0	8	3
15	R:R:E530	R:R:N527	11.83	No	Yes	0	4	8
16	R:R:D531	R:R:N527	6.73	No	Yes	0	7	8
17	R:R:N527	R:R:Q536	6.6	Yes	No	0	8	1
18	R:R:E532	R:R:H528	3.69	No	No	0	6	4
19	R:R:H528	R:R:T549	8.21	No	No	0	4	5
20	R:R:E530	R:R:T529	9.88	No	No	0	4	6
21	R:R:E534	R:R:Y533	3.37	No	No	0	4	3
22	R:R:E534	R:R:Q536	8.92	No	No	0	4	1
23	R:R:C538	R:R:P539	3.77	Yes	No	0	9	4
24	R:R:C538	R:R:E542	4.56	Yes	Yes	4	9	6
25	R:R:C538	R:R:C551	7.28	Yes	Yes	4	9	9
26	R:R:N540	R:R:P539	4.89	No	No	0	3	4
27	R:R:E542	R:R:N540	2.63	Yes	No	0	6	3
28	R:R:E542	R:R:N541	11.83	Yes	No	0	6	5
29	R:R:K553	R:R:N541	6.99	No	No	0	4	5
30	R:R:C551	R:R:E542	4.56	Yes	Yes	4	9	6
31	R:R:R554	R:R:W543	10	No	Yes	0	8	7
32	R:R:P713	R:R:W543	6.76	No	Yes	0	4	7
33	R:R:E548	R:R:S544	2.87	No	No	0	5	8
34	R:R:C551	R:R:S544	3.44	Yes	No	4	9	8
35	R:R:F552	R:R:Y545	18.57	No	No	0	4	7
36	R:R:Q546	R:R:S547	5.78	No	No	0	1	3
37	R:R:E548	R:R:F552	7	No	No	0	5	4
38	R:R:K553	R:R:Q555	8.14	No	No	0	4	3
39	R:R:R554	R:R:T708	9.06	No	No	0	8	4
40	R:R:R554	R:R:T716	7.76	No	No	0	8	7
41	R:R:K714	R:R:Q555	8.14	No	No	0	4	3
42	R:R:L556	R:R:V718	5.96	No	Yes	0	4	7
43	R:R:I715	R:R:V557	3.07	Yes	No	0	4	5
44	R:R:F558	R:R:P624	5.78	No	No	0	7	5
45	R:R:F558	R:R:P625	4.33	No	No	0	7	9
46	R:R:L559	R:R:T566	4.42	No	No	0	8	7
47	R:R:L559	R:R:V622	4.47	No	No	0	8	7
48	R:R:L559	R:R:T789	7.37	No	No	0	8	7
49	R:R:E560	R:R:E563	3.81	No	No	0	6	8
50	R:R:V622	R:R:W561	4.9	No	No	0	7	5
51	R:R:E563	R:R:T566	4.23	No	No	0	8	7
52	R:R:I790	R:R:P565	5.08	No	No	0	8	6
53	R:R:I790	R:R:V569	3.07	No	No	0	8	8
54	R:R:L793	R:R:V569	2.98	No	No	0	8	8
55	R:R:L794	R:R:V569	2.98	No	No	0	7	8
56	R:R:L572	R:R:V797	5.96	No	No	0	3	9
57	R:R:L572	R:R:L798	5.54	No	No	0	3	7
58	R:R:L572	R:R:L801	5.54	No	No	0	3	6
59	R:R:A573	R:R:V797	3.39	No	No	0	7	9
60	R:R:G576	R:R:S579	3.71	No	No	0	6	4
61	R:R:F577	R:R:T580	2.59	No	Yes	13	6	8
62	R:R:F577	R:R:L612	9.74	No	No	13	6	4
63	R:R:F577	R:R:Y615	7.22	No	Yes	0	6	8
64	R:R:S579	R:R:T580	3.2	No	Yes	0	4	8
65	R:R:L612	R:R:T580	4.42	No	Yes	13	4	8
66	R:R:S804	R:R:T580	3.2	No	Yes	0	8	8
67	R:R:F587	R:R:I583	3.77	No	No	0	9	7
68	R:R:F808	R:R:I583	2.51	No	No	0	9	7
69	R:R:C812	R:R:I583	4.91	No	No	0	7	7
70	R:R:L584	R:R:L608	11.07	No	No	0	4	9
71	R:R:I586	R:R:R589	3.76	No	No	0	5	4
72	R:R:C812	R:R:I586	6.55	No	No	0	7	5
73	R:R:F587	R:R:K811	8.69	No	Yes	0	9	9
74	R:R:F587	R:R:I815	3.77	No	Yes	0	9	8
75	R:R:F591	R:R:W588	7.02	No	No	0	5	5
76	R:R:F605	R:R:W588	8.02	No	No	0	6	5
77	R:R:H590	R:R:R589	16.93	No	No	0	5	4
78	R:R:H590	R:R:T593	8.21	No	Yes	15	5	9
79	R:R:H590	R:R:I815	3.98	No	Yes	15	5	8
80	R:R:T593	R:R:V596	3.17	Yes	No	0	9	9
81	R:R:I815	R:R:T593	3.04	Yes	Yes	15	8	9
82	R:R:N822	R:R:T593	10.24	No	Yes	0	9	9
83	R:R:F827	R:R:P594	11.56	Yes	No	0	7	8
84	R:R:I595	R:R:K811	4.36	Yes	Yes	0	7	9
85	R:R:I595	R:R:I815	11.77	Yes	Yes	0	7	8
86	R:R:I595	R:R:R821	3.76	Yes	No	0	7	5
87	R:R:I595	R:R:N822	5.66	Yes	No	0	7	9
88	R:R:S598	R:R:Y756	16.53	No	Yes	2	9	9
89	R:R:F827	R:R:S598	6.61	Yes	No	2	7	9
90	R:R:A599	R:R:C604	3.61	No	No	0	9	9
91	R:R:G601	R:R:P602	4.06	No	No	0	8	6
92	R:R:C647	R:R:M603	4.86	No	Yes	0	7	8
93	R:R:M603	R:R:R651	4.96	Yes	No	0	8	9
94	R:R:M603	R:R:Y679	8.38	Yes	No	0	8	5
95	R:R:C604	R:R:F605	2.79	No	No	0	9	6
96	R:R:L606	R:R:L610	2.77	No	No	0	6	8
97	R:R:C644	R:R:M607	3.24	No	Yes	0	7	8
98	R:R:C647	R:R:M607	3.24	No	Yes	0	7	8
99	R:R:I648	R:R:M607	2.92	No	Yes	0	7	8
100	R:R:M607	R:R:Y807	3.59	Yes	Yes	14	8	8
101	R:R:F808	R:R:M607	4.98	No	Yes	14	9	8
102	R:R:L608	R:R:L612	2.77	No	No	0	9	4
103	R:R:C644	R:R:L611	4.76	No	No	0	7	9
104	R:R:I803	R:R:L611	2.85	No	No	0	8	9
105	R:R:M616	R:R:V613	4.56	No	No	0	6	6
106	R:R:A614	R:R:L800	4.73	No	No	0	6	8
107	R:R:L800	R:R:Y615	11.72	No	Yes	0	8	8
108	R:R:L801	R:R:Y615	7.03	No	Yes	0	6	8
109	R:R:S804	R:R:Y615	7.63	No	Yes	0	8	8
110	R:R:M616	R:R:V617	3.04	No	No	0	6	6
111	R:R:V617	R:R:V620	3.21	No	Yes	0	6	6
112	R:R:P619	R:R:V618	3.53	No	No	0	6	7
113	R:R:L793	R:R:V618	7.45	No	No	0	8	7
114	R:R:V618	R:R:V797	3.21	No	No	0	7	9
115	R:R:T629	R:R:V620	3.17	No	Yes	0	6	6
116	R:R:R633	R:R:V620	5.23	Yes	Yes	0	8	6
117	R:R:R633	R:R:Y621	26.75	Yes	No	0	8	8
118	R:R:L793	R:R:Y621	10.55	No	No	0	8	8
119	R:R:G623	R:R:P624	4.06	No	No	0	8	5
120	R:R:P625	R:R:V718	5.3	No	Yes	0	9	7
121	R:R:K626	R:R:S628	12.24	No	No	16	5	4
122	R:R:K626	R:R:T629	6.01	No	No	16	5	6
123	R:R:L702	R:R:V627	2.98	No	No	0	8	4
124	R:R:S628	R:R:T629	4.8	No	No	16	4	6
125	R:R:C630	R:R:Q634	3.05	No	Yes	0	9	8
126	R:R:C630	R:R:C720	7.28	No	No	0	9	9
127	R:R:C632	R:R:L636	3.17	No	No	0	6	6
128	R:R:R633	R:R:S719	3.95	Yes	No	0	8	5
129	R:R:C720	R:R:R633	15.32	No	Yes	0	9	8
130	R:R:M697	R:R:Q634	6.8	No	Yes	0	7	8
131	R:R:L702	R:R:Q634	5.32	No	Yes	0	8	8
132	R:R:P722	R:R:Q634	11.05	No	Yes	0	6	8
133	R:R:F637	R:R:P638	8.67	No	No	0	8	5
134	R:R:F637	R:R:T796	9.08	No	No	0	8	8
135	R:R:F641	R:R:I645	5.02	No	No	0	8	7
136	R:R:F641	R:R:Y769	9.28	No	No	0	8	8
137	R:R:F641	R:R:N799	10.87	No	No	0	8	9
138	R:R:K689	R:R:T642	18.02	No	No	8	9	8
139	R:R:L734	R:R:T642	2.95	Yes	No	8	8	8
140	R:R:D735	R:R:T642	8.67	No	No	8	8	8
141	R:R:I643	R:R:M682	2.92	No	Yes	3	7	7
142	R:R:I643	R:R:T686	4.56	No	Yes	3	7	7
143	R:R:D735	R:R:I645	5.6	No	No	0	8	7
144	R:R:I645	R:R:L738	7.14	No	Yes	0	7	9
145	R:R:I685	R:R:S646	10.84	No	No	3	5	9
146	R:R:L738	R:R:S646	6.01	Yes	No	3	9	9
147	R:R:I648	R:R:I762	5.89	No	No	0	7	9
148	R:R:I648	R:R:I803	2.94	No	No	0	7	8
149	R:R:P678	R:R:V650	3.53	No	No	0	8	8
150	R:R:R651	R:R:Y807	4.12	No	Yes	0	9	8
151	R:R:F745	R:R:S652	6.61	No	No	0	7	9
152	R:R:C657	R:R:F653	15.36	No	No	0	6	7
153	R:R:I655	R:R:N755	4.25	No	No	2	9	8
154	R:R:E758	R:R:I655	12.3	No	No	2	9	9
155	R:R:K660	R:R:V656	3.04	No	No	0	6	7
156	R:R:C657	R:R:M661	3.24	No	Yes	0	6	7
157	R:R:C657	R:R:F745	2.79	No	No	0	6	7
158	R:R:A658	R:R:F659	5.55	No	No	0	8	9
159	R:R:K660	R:R:M661	5.76	No	Yes	0	6	7
160	R:R:F665	R:R:M661	3.73	No	Yes	0	5	7
161	R:R:M661	R:R:Y669	15.57	Yes	No	0	7	7
162	R:R:A662	R:R:Y669	2.67	No	No	0	7	7
163	R:R:F665	R:R:R664	16.03	No	No	0	5	7
164	R:R:A668	R:R:R667	2.77	No	No	0	5	5
165	R:R:V673	R:R:Y669	13.88	No	No	0	6	7
166	R:R:R674	R:R:Y671	6.17	No	No	0	7	5
167	R:R:Q676	R:R:Y675	16.91	No	No	0	3	6
168	R:R:Q676	R:R:V680	2.87	No	No	0	3	4
169	R:R:G677	R:R:P678	4.06	No	No	0	8	8
170	R:R:M682	R:R:T686	3.01	Yes	Yes	3	7	7
171	R:R:I685	R:R:L738	4.28	No	Yes	3	5	9
172	R:R:M690	R:R:T686	4.52	No	Yes	0	4	7
173	R:R:M690	R:R:V687	3.04	No	No	0	4	5
174	R:R:K689	R:R:V693	4.55	No	No	0	9	7
175	R:R:K689	R:R:L734	2.82	No	Yes	8	9	8
176	R:R:I695	R:R:V691	4.61	No	No	0	4	3
177	R:R:F730	R:R:I692	7.54	No	No	0	4	6
178	R:R:F730	R:R:G696	6.02	No	No	0	4	7
179	R:R:G701	R:R:T700	3.64	No	No	0	8	6
180	R:R:N721	R:R:T700	8.77	No	No	0	6	6
181	R:R:N721	R:R:T705	4.39	No	No	0	6	3
182	R:R:T706	R:R:V718	3.17	No	Yes	0	3	7
183	R:R:I717	R:R:R707	2.51	No	No	0	6	6
184	R:R:R707	R:R:Y783	6.17	No	No	0	6	8
185	R:R:D709	R:R:P710	6.44	Yes	No	0	3	4
186	R:R:D709	R:R:D711	19.96	Yes	No	5	3	5
187	R:R:D709	R:R:I715	9.8	Yes	Yes	5	3	4
188	R:R:D709	R:R:V786	5.84	Yes	No	0	3	8
189	R:R:D711	R:R:D712	11.98	No	Yes	5	5	4
190	R:R:D711	R:R:I715	12.59	No	Yes	5	5	4
191	R:R:D712	R:R:K714	5.53	Yes	No	5	4	4
192	R:R:D712	R:R:I715	12.59	Yes	Yes	5	4	4
193	R:R:I715	R:R:K714	4.36	Yes	No	5	4	4
194	R:R:I717	R:R:V786	4.61	No	No	0	6	8
195	R:R:N723	R:R:S719	11.92	No	No	0	5	5
196	R:R:N721	R:R:P722	3.26	No	No	0	6	6
197	R:R:P722	R:R:S727	5.34	No	No	0	6	6
198	R:R:C777	R:R:R725	2.79	No	Yes	0	7	2
199	R:R:M780	R:R:R725	8.69	Yes	Yes	0	8	2
200	R:R:D792	R:R:L728	4.07	Yes	No	0	9	7
201	R:R:L729	R:R:T732	5.9	No	No	0	5	7
202	R:R:N731	R:R:T732	4.39	No	No	0	7	7
203	R:R:D735	R:R:L734	5.43	No	Yes	8	8	8
204	R:R:F770	R:R:L736	6.09	No	No	0	6	6
205	R:R:M766	R:R:S739	3.07	No	No	0	9	8
206	R:R:S739	R:R:Y769	7.63	No	No	0	8	8
207	R:R:F770	R:R:V740	3.93	No	No	0	6	2
208	R:R:F745	R:R:V741	3.93	No	No	0	7	4
209	R:R:F743	R:R:T763	5.19	Yes	No	0	8	9
210	R:R:F743	R:R:M766	7.46	Yes	No	0	8	9
211	R:R:F743	R:R:T767	2.59	Yes	No	0	8	8
212	R:R:F743	S:S:F749	4.29	Yes	Yes	0	8	8
213	R:R:A746	R:R:I762	3.25	No	No	0	9	9
214	R:R:K750	R:R:Y747	10.75	No	No	0	9	8
215	R:R:Y747	S:S:F749	8.25	No	Yes	0	8	8
216	R:R:G749	R:R:P753	4.06	No	No	0	9	9
217	R:R:K750	S:S:R752	7.43	No	No	0	9	9
218	R:R:E751	S:S:R752	3.49	No	No	0	7	9
219	R:R:N755	R:R:Y756	3.49	No	Yes	2	8	9
220	R:R:E758	R:R:N755	3.94	No	No	2	9	8
221	R:R:E758	R:R:Y756	25.81	No	Yes	2	9	9
222	R:R:F827	R:R:Y756	3.09	Yes	Yes	2	7	9
223	R:R:K760	S:S:E663	5.4	No	No	0	9	6
224	R:R:F761	R:R:P810	15.89	No	No	0	5	9
225	R:R:T763	S:S:L750	4.42	No	No	0	9	8
226	R:R:L764	S:S:L750	2.77	No	No	0	9	8
227	R:R:M766	R:R:S765	4.6	No	No	0	9	9
228	R:R:I803	R:R:S765	3.1	No	No	0	8	9
229	R:R:A802	R:R:F768	5.55	No	No	0	7	7
230	R:R:T771	S:S:F742	6.49	No	No	0	8	3
231	R:R:S772	R:R:V795	6.46	No	No	0	9	8
232	R:R:S773	R:R:V774	3.23	No	No	0	9	6
233	R:R:L776	R:R:M780	2.83	No	Yes	9	9	8
234	R:R:D792	R:R:L776	4.07	Yes	No	9	9	9
235	R:R:L776	R:R:V795	8.94	No	No	0	9	8
236	R:R:T778	S:S:V776	4.76	No	No	0	8	6
237	R:R:T778	S:S:V779	3.17	No	Yes	0	8	6
238	R:R:F779	R:R:M780	6.22	No	Yes	0	7	8
239	R:R:F779	R:R:S784	5.28	No	No	0	7	6
240	R:R:F779	R:R:V791	10.49	No	No	0	7	7
241	R:R:M780	R:R:V788	9.13	Yes	No	9	8	7
242	R:R:D792	R:R:M780	4.16	Yes	Yes	9	9	8
243	R:R:A782	S:S:W727	6.48	No	No	0	8	3
244	R:R:G785	R:R:Y783	5.79	No	No	0	7	8
245	R:R:V788	R:R:Y783	2.52	No	No	0	7	8
246	R:R:L787	R:R:S784	9.01	No	No	0	5	6
247	R:R:I790	R:R:L787	2.85	No	No	0	8	5
248	R:R:D792	R:R:V788	2.92	Yes	No	9	9	7
249	R:R:N799	R:R:T796	2.92	No	No	0	9	8
250	R:R:L800	R:R:N799	4.12	No	No	0	8	9
251	R:R:F808	R:R:Y807	12.38	No	Yes	14	9	8
252	R:R:K811	R:R:Y807	4.78	Yes	Yes	0	9	8
253	R:R:G809	R:R:P810	4.06	No	No	0	3	9
254	R:R:F817	R:R:Y813	35.07	No	No	17	5	8
255	R:R:Y813	R:R:Y818	6.95	No	No	17	8	6
256	R:R:M814	R:R:R821	16.13	No	No	0	8	5
257	R:R:F817	R:R:L816	4.87	No	No	0	5	6
258	R:R:F817	R:R:Y818	6.19	No	No	17	5	6
259	R:R:E820	R:R:R821	11.63	No	No	0	7	5
260	R:R:T823	R:R:Y826	3.75	No	No	0	7	5
261	R:R:M830	R:R:Y826	9.58	No	No	0	4	5
262	R:R:F827	R:R:I831	5.02	Yes	No	0	7	7
263	S:S:F540	S:S:W546	3.01	No	Yes	0	3	7
264	S:S:F540	S:S:S547	2.64	No	No	0	3	8
265	S:S:C541	S:S:S547	6.89	No	No	0	9	8
266	S:S:C541	S:S:C554	7.28	No	No	0	9	9
267	S:S:D544	S:S:Q543	10.44	No	Yes	10	6	3
268	S:S:Q543	S:S:W711	17.52	Yes	Yes	10	3	3
269	S:S:H712	S:S:Q543	4.95	No	Yes	10	3	3
270	S:S:D544	S:S:E545	3.9	No	No	0	6	6
271	S:S:D544	S:S:W711	5.58	No	Yes	10	6	3
272	S:S:C554	S:S:E545	3.04	No	No	0	9	6
273	S:S:E545	S:S:R556	6.98	No	No	0	6	4
274	S:S:E549	S:S:W546	5.45	No	Yes	0	2	7
275	S:S:R557	S:S:W546	8	No	Yes	0	8	7
276	S:S:P715	S:S:W546	4.05	No	Yes	0	3	7
277	S:S:T716	S:S:W546	6.06	No	Yes	0	4	7
278	S:S:P548	S:S:S551	5.34	No	No	0	8	5
279	S:S:F555	S:S:R553	3.21	No	No	0	4	2
280	S:S:F555	S:S:R558	12.83	No	No	0	4	3
281	S:S:R558	S:S:T716	6.47	No	No	0	3	4
282	S:S:E717	S:S:R558	5.82	No	No	0	3	3
283	S:S:F561	S:S:S559	2.64	Yes	No	0	6	4
284	S:S:E717	S:S:R560	17.45	No	No	0	3	5
285	S:S:L719	S:S:R560	4.86	No	No	0	7	5
286	S:S:R560	S:S:V788	2.62	No	No	0	5	7
287	S:S:F561	S:S:Q627	5.86	Yes	No	11	6	4
288	S:S:F561	S:S:P628	4.33	Yes	Yes	11	6	9
289	S:S:F561	S:S:V720	3.93	Yes	No	11	6	6
290	S:S:L562	S:S:V569	2.98	No	No	0	8	7
291	S:S:P625	S:S:W564	6.76	Yes	No	0	7	6
292	S:S:G626	S:S:W564	2.81	No	No	0	8	6
293	S:S:E566	S:S:P567	3.14	No	No	0	7	3
294	S:S:L573	S:S:V569	2.98	No	No	0	5	7
295	S:S:L572	S:S:M795	2.83	No	Yes	0	8	7
296	S:S:L575	S:S:L799	12.46	No	No	0	3	8
297	S:S:L576	S:S:V621	2.98	No	No	0	6	7
298	S:S:L578	S:S:L582	2.77	No	No	0	4	4
299	S:S:L578	S:S:L803	4.15	No	No	0	4	6
300	S:S:L580	S:S:L584	2.77	No	No	0	5	2
301	S:S:L580	S:S:L619	6.92	No	No	0	5	5
302	S:S:L582	S:S:V583	4.47	No	No	6	4	7
303	S:S:L582	S:S:L806	4.15	No	Yes	6	4	8
304	S:S:L806	S:S:V583	2.98	Yes	No	6	8	7
305	S:S:A586	S:S:L611	3.15	No	Yes	0	7	9
306	S:S:L587	S:S:L611	4.15	No	Yes	0	4	9
307	S:S:L587	S:S:V612	4.47	No	No	0	4	4
308	S:S:C814	S:S:L589	4.76	No	No	0	8	5
309	S:S:L589	S:S:M818	8.48	No	No	0	5	6
310	S:S:A607	S:S:F590	2.77	No	No	0	8	9
311	S:S:F590	S:S:L611	4.87	No	Yes	0	9	9
312	S:S:C814	S:S:F590	2.79	No	No	0	8	9
313	S:S:H592	S:S:H593	20.3	No	No	0	3	5
314	S:S:H593	S:S:S596	2.79	No	Yes	0	5	9
315	S:S:H593	S:S:L817	5.14	No	Yes	0	5	8
316	S:S:D595	S:S:Q600	6.53	No	No	0	5	7
317	S:S:P597	S:S:S596	3.56	No	Yes	0	8	9
318	S:S:S596	S:S:V599	3.23	Yes	No	0	9	9
319	S:S:Q820	S:S:S596	4.33	Yes	Yes	0	6	9
320	S:S:L598	S:S:L816	2.77	No	No	0	7	8
321	S:S:L598	S:S:L817	5.54	No	Yes	18	7	8
322	S:S:L598	S:S:Q820	6.65	No	Yes	18	7	6
323	S:S:L817	S:S:V599	4.47	Yes	No	0	8	9
324	S:S:R813	S:S:S602	2.64	No	No	0	9	9
325	S:S:G604	S:S:P605	4.06	Yes	No	0	8	6
326	S:S:A681	S:S:L606	4.73	No	No	0	8	8
327	S:S:L606	S:S:W682	12.53	No	No	0	8	5
328	S:S:F609	S:S:G610	3.01	No	No	0	6	8
329	S:S:F609	S:S:W682	6.01	No	No	0	6	5
330	S:S:F609	S:S:V685	2.62	No	No	0	6	8
331	S:S:C647	S:S:G610	3.92	No	No	0	7	8
332	S:S:H810	S:S:L611	7.71	Yes	Yes	0	9	9
333	S:S:C613	S:S:C647	3.64	No	No	0	8	7
334	S:S:C647	S:S:L614	3.17	No	Yes	0	7	9
335	S:S:L614	S:S:V802	2.98	Yes	No	0	9	8
336	S:S:L614	S:S:L806	2.77	Yes	Yes	6	9	8
337	S:S:H810	S:S:L614	2.57	Yes	Yes	6	9	9
338	S:S:S620	S:S:V617	3.23	No	No	0	6	5
339	S:S:P643	S:S:V617	8.84	No	No	0	6	5
340	S:S:C618	S:S:V802	5.12	No	No	0	8	8
341	S:S:S620	S:S:S640	4.89	No	No	0	6	7
342	S:S:L799	S:S:V621	2.98	No	No	0	8	7
343	S:S:L623	S:S:R632	4.86	No	No	0	5	6
344	S:S:F624	S:S:Q636	23.42	Yes	No	0	7	8
345	S:S:F624	S:S:S640	3.96	Yes	No	0	7	7
346	S:S:F624	S:S:Q794	10.54	Yes	No	0	7	8
347	S:S:M795	S:S:P625	6.71	Yes	Yes	0	7	7
348	S:S:P628	S:S:Q627	9.47	Yes	No	11	9	4
349	S:S:P628	S:S:V707	5.3	Yes	No	0	9	5
350	S:S:P628	S:S:V720	8.84	Yes	No	11	9	6
351	S:S:P630	S:S:S629	5.34	No	No	0	3	5
352	S:S:R632	S:S:S629	5.27	No	No	0	6	5
353	S:S:C633	S:S:C722	7.28	No	No	7	9	9
354	S:S:A635	S:S:L639	3.15	No	No	0	6	6
355	S:S:F730	S:S:Q637	9.37	No	No	0	7	8
356	S:S:A733	S:S:Q637	3.03	No	No	0	6	8
357	S:S:C696	S:S:P638	3.77	No	No	0	7	5
358	S:S:P638	S:S:Y699	6.95	No	Yes	0	5	6
359	S:S:L798	S:S:S640	3	No	No	0	8	7
360	S:S:A733	S:S:H641	4.39	No	No	0	6	5
361	S:S:H641	S:S:W775	4.23	No	Yes	0	5	9
362	S:S:L642	S:S:P643	4.93	No	No	0	7	6
363	S:S:L642	S:S:M689	8.48	No	No	0	7	7
364	S:S:E692	S:S:L642	2.65	Yes	No	0	9	7
365	S:S:L644	S:S:L648	2.77	No	No	0	8	7
366	S:S:L644	S:S:N737	2.75	No	Yes	0	8	7
367	S:S:E692	S:S:T645	7.06	Yes	Yes	1	9	7
368	S:S:T645	S:S:T736	6.28	Yes	No	1	7	8
369	S:S:N737	S:S:T645	7.31	Yes	Yes	1	7	7
370	S:S:A688	S:S:S649	3.42	No	No	0	4	9
371	S:S:L651	S:S:L764	4.15	No	No	0	7	9
372	S:S:F809	S:S:L651	10.96	Yes	No	0	8	7
373	S:S:F652	S:S:L740	6.09	No	No	0	8	9
374	S:S:F652	S:S:L743	3.65	No	No	0	8	4
375	S:S:C744	S:S:F652	4.19	No	No	0	8	8
376	S:S:A681	S:S:L653	4.73	No	No	0	8	7
377	S:S:Q654	S:S:R760	4.67	No	No	0	9	9
378	S:S:E657	S:S:V660	2.85	No	Yes	0	8	6
379	S:S:E657	S:S:L676	11.93	No	No	0	8	6
380	S:S:I658	S:S:R760	10.02	No	No	0	9	9
381	S:S:F659	S:S:S662	3.96	Yes	No	0	6	9
382	S:S:E663	S:S:F659	7	No	Yes	0	6	6
383	S:S:F659	S:S:L664	6.09	Yes	No	0	6	6
384	S:S:L664	S:S:V660	4.47	No	Yes	0	6	6
385	S:S:L672	S:S:V660	10.43	No	Yes	0	4	6
386	S:S:A669	S:S:E661	3.02	No	No	0	7	8
387	S:S:S662	S:S:V751	3.23	No	No	0	9	8
388	S:S:L664	S:S:P665	3.28	No	No	0	6	7
389	S:S:P665	S:S:W668	2.7	No	No	0	7	5
390	S:S:R671	S:S:W668	14.99	No	No	0	4	5
391	S:S:L672	S:S:R671	8.5	No	No	0	4	4
392	S:S:L672	S:S:L676	2.77	No	No	0	4	6
393	S:S:G674	S:S:S673	3.71	No	No	0	6	5
394	S:S:C675	S:S:W680	11.75	No	No	0	4	7
395	S:S:L676	S:S:W680	5.69	No	No	0	6	7
396	S:S:G678	S:S:P679	4.06	No	No	0	5	3
397	S:S:L695	S:S:V691	2.98	No	No	0	7	5
398	S:S:C696	S:S:E692	4.56	No	Yes	0	7	9
399	S:S:E692	S:S:T736	8.47	Yes	No	1	9	8
400	S:S:L695	S:S:L732	4.15	No	No	0	7	4
401	S:S:P705	S:S:Y699	6.95	Yes	Yes	0	8	6
402	S:S:S729	S:S:Y699	6.36	No	Yes	0	6	6
403	S:S:L732	S:S:Y699	4.69	No	Yes	0	4	6
404	S:S:L700	S:S:V701	2.98	No	No	0	7	2
405	S:S:A702	S:S:F703	5.55	No	No	0	3	5
406	S:S:F703	S:S:V728	2.62	No	No	0	5	3
407	S:S:D710	S:S:V708	2.92	No	No	0	7	4
408	S:S:R723	S:S:V708	6.54	No	No	0	6	4
409	S:S:T709	S:S:W711	10.92	No	Yes	0	3	3
410	S:S:H712	S:S:W711	8.46	No	Yes	10	3	3
411	S:S:A718	S:S:W711	2.59	No	Yes	0	7	3
412	S:S:M713	S:S:V787	9.13	No	Yes	0	5	7
413	S:S:L714	S:S:P715	4.93	No	No	0	3	3
414	S:S:L714	S:S:Q786	3.99	No	No	0	3	6
415	S:S:H721	S:S:L719	2.57	No	No	0	6	7
416	S:S:L719	S:S:V787	2.98	No	Yes	0	7	7
417	S:S:R725	S:S:V728	2.62	No	No	0	6	3
418	S:S:F730	S:S:W727	4.01	No	No	0	7	3
419	S:S:V779	S:S:W727	4.9	Yes	No	0	6	3
420	S:S:A738	S:S:H734	2.93	No	Yes	1	4	7
421	S:S:H734	S:S:Y771	9.8	Yes	Yes	1	7	8
422	S:S:H734	S:S:W775	14.81	Yes	Yes	1	7	9
423	S:S:N737	S:S:T736	4.39	Yes	No	1	7	8
424	S:S:N737	S:S:Y771	11.63	Yes	Yes	1	7	8
425	S:S:A738	S:S:Y771	2.67	No	Yes	1	4	8
426	S:S:A741	S:S:M768	3.22	No	No	0	8	9
427	S:S:A741	S:S:Y771	2.67	No	Yes	1	8	8
428	S:S:A741	S:S:F772	4.16	No	No	1	8	6
429	S:S:F742	S:S:L746	14.61	No	No	0	3	4
430	S:S:C744	S:S:M768	4.86	No	No	0	8	9
431	S:S:F745	S:S:F749	9.65	Yes	Yes	0	9	8
432	S:S:F745	S:S:T765	7.78	Yes	No	0	9	9
433	S:S:F745	S:S:F772	5.36	Yes	No	0	9	6
434	S:S:A761	S:S:T748	3.36	No	No	0	9	9
435	S:S:L764	S:S:T748	2.95	No	No	0	9	9
436	S:S:T748	S:S:T765	6.28	No	No	0	9	9
437	S:S:F749	S:S:L750	9.74	Yes	No	0	8	8
438	S:S:A761	S:S:V751	3.39	No	No	0	9	8
439	S:S:R752	S:S:S753	3.95	No	No	0	9	7
440	S:S:P755	S:S:Q754	3.16	No	No	0	9	8
441	S:S:C757	S:S:Q754	13.74	No	No	0	7	8
442	S:S:N759	S:S:Q754	3.96	No	No	0	9	8
443	S:S:R813	S:S:Y758	8.23	No	No	0	9	9
444	S:S:A761	S:S:N759	4.69	No	No	0	9	9
445	S:S:F766	S:S:R762	6.41	No	No	0	9	9
446	S:S:F766	S:S:L769	6.09	No	No	0	9	8
447	S:S:I773	S:S:L769	2.85	No	No	0	8	8
448	S:S:F772	S:S:Y771	4.13	No	Yes	1	6	8
449	S:S:W775	S:S:Y771	16.4	Yes	Yes	1	9	8
450	S:S:C801	S:S:T774	5.07	No	No	0	9	9
451	S:S:F778	S:S:W775	9.02	No	Yes	0	9	9
452	S:S:F778	S:S:V779	6.55	No	Yes	0	9	6
453	S:S:F778	S:S:L782	6.09	No	No	0	9	8
454	S:S:P780	S:S:V779	3.53	No	Yes	0	9	6
455	S:S:L782	S:S:R790	3.64	No	Yes	0	8	7
456	S:S:L782	S:S:V793	10.43	No	No	0	8	8
457	S:S:A783	S:S:N784	3.13	No	No	0	5	8
458	S:S:R790	S:S:V785	5.23	Yes	No	0	7	7
459	S:S:Q786	S:S:V787	7.16	No	Yes	0	6	7
460	S:S:Q786	S:S:V788	5.73	No	No	0	6	7
461	S:S:R790	S:S:V787	5.23	Yes	Yes	0	7	7
462	S:S:L789	S:S:V788	2.98	No	No	0	5	7
463	S:S:P791	S:S:R790	2.88	No	Yes	0	6	7
464	S:S:L798	S:S:Q794	10.65	No	No	0	8	8
465	S:S:H810	S:S:L806	5.14	Yes	Yes	6	9	8
466	S:S:F809	S:S:H810	18.1	Yes	Yes	0	8	9
467	S:S:F809	S:S:R813	10.69	Yes	No	0	8	9
468	S:S:L811	S:S:P812	6.57	No	No	0	4	9
469	S:S:L816	S:S:Y815	3.52	No	No	0	8	8
470	S:S:R819	S:S:Y815	24.69	No	No	0	5	8
471	S:S:L817	S:S:Q820	5.32	Yes	Yes	18	8	6
472	S:S:L823	S:S:R819	13.36	No	No	0	5	5
473	R:R:T705	R:R:Y724	2.5	No	No	0	3	8
474	S:S:F624	S:S:M795	2.49	Yes	Yes	0	7	7
475	R:R:F761	R:R:K760	2.48	No	No	0	5	9
476	S:S:S667	S:S:W668	2.47	No	No	0	6	5
477	R:R:F605	R:R:L584	2.44	No	No	0	6	4
478	R:R:F768	R:R:L798	2.44	No	No	0	7	7
479	S:S:F745	S:S:L746	2.44	Yes	No	0	9	4
480	R:R:K811	R:R:Y756	2.39	Yes	Yes	0	9	9
481	R:R:M814	R:R:Y813	2.39	No	No	0	8	8
482	R:R:F591	R:R:Q592	2.34	No	No	0	5	4
483	R:R:L736	R:R:Y769	2.34	No	No	0	6	8
484	S:S:F809	S:S:Q654	2.34	Yes	No	0	8	9
485	S:S:H721	S:S:R723	2.26	No	No	0	6	6
486	R:R:G600	R:R:G601	2.11	No	No	0	9	8
487	S:S:G603	S:S:G604	2.11	No	Yes	0	9	8
488	S:S:C618	S:S:G615	1.96	No	No	0	8	4
489	S:S:C757	S:S:G756	1.96	No	No	0	7	7
490	R:R:A699	R:R:G696	1.95	No	No	0	4	7
491	S:S:A607	S:S:G604	1.95	No	Yes	0	8	8
492	S:S:P704	S:S:P705	1.95	No	Yes	7	7	8
493	S:S:A770	S:S:G804	1.95	No	No	0	7	7
494	S:S:C633	S:S:P705	1.88	No	Yes	7	9	8
495	S:S:C722	S:S:P705	1.88	No	Yes	7	9	8
496	R:R:A564	R:R:P565	1.87	No	No	0	4	6
497	R:R:G742	R:R:S652	1.86	No	No	0	9	9
498	S:S:G646	S:S:S649	1.86	No	No	0	6	9
499	R:R:G623	R:R:V622	1.84	No	No	0	8	7
500	S:S:G588	S:S:V591	1.84	No	No	0	1	4
501	S:S:G604	S:S:V599	1.84	Yes	No	0	8	9
502	S:S:G646	S:S:T645	1.82	No	Yes	0	6	7
503	S:S:A655	S:S:C744	1.81	No	No	0	9	8
504	S:S:A767	S:S:A808	1.79	No	No	0	9	6
505	R:R:P704	R:R:S703	1.78	No	No	0	6	4
506	S:S:P548	S:S:S547	1.78	No	No	0	8	8
507	R:R:P704	R:R:V627	1.77	No	No	0	6	4
508	R:R:P704	R:R:V718	1.77	No	Yes	0	6	7
509	S:S:P625	S:S:V569	1.77	Yes	No	0	7	7
510	R:R:G696	R:R:I695	1.76	No	No	0	7	4
511	R:R:G749	R:R:M748	1.75	No	No	0	9	7
512	R:R:P824	R:R:T823	1.75	No	No	0	6	7
513	S:S:G796	S:S:M795	1.75	No	Yes	0	7	7
514	R:R:G576	R:R:L575	1.71	No	No	0	6	2
515	R:R:C632	R:R:V620	1.71	No	Yes	0	6	6
516	S:S:G588	S:S:L587	1.71	No	No	0	1	4
517	S:S:G796	S:S:L800	1.71	No	No	0	7	6
518	S:S:A669	S:S:V660	1.7	No	Yes	0	7	6
519	R:R:I655	R:R:P753	1.69	No	No	0	9	9
520	R:R:A537	R:R:T524	1.68	No	No	0	3	7
521	R:R:A683	R:R:T686	1.68	No	Yes	0	3	7
522	R:R:A699	R:R:T700	1.68	No	No	0	4	6
523	R:R:L752	R:R:P753	1.64	No	No	0	8	9
524	S:S:G542	S:S:Q543	1.64	No	Yes	0	5	3
525	S:S:L634	S:S:P704	1.64	No	No	7	5	7
526	S:S:L634	S:S:P705	1.64	No	Yes	7	5	8
527	R:R:N731	R:R:P638	1.63	No	No	0	7	5
528	R:R:N822	R:R:P819	1.63	No	No	0	9	8
529	S:S:S729	S:S:V728	1.62	No	No	0	6	3
530	R:R:D712	R:R:P713	1.61	Yes	No	0	4	4
531	R:R:S550	R:R:T549	1.6	No	No	0	2	5
532	R:R:V774	S:S:V776	1.6	No	No	0	6	6
533	R:R:C640	R:R:L610	1.59	No	No	0	7	8
534	S:S:C618	S:S:L580	1.59	No	No	0	8	5
535	S:S:T709	S:S:V720	1.59	No	No	0	3	6
536	S:S:G731	S:S:H734	1.59	No	Yes	0	4	7
537	R:R:A635	R:R:L631	1.58	No	No	0	5	5
538	R:R:A635	R:R:L636	1.58	No	No	0	5	6
539	R:R:A649	R:R:L738	1.58	No	Yes	0	8	9
540	R:R:P678	R:R:Q654	1.58	No	No	0	8	8
541	S:S:A792	S:S:L562	1.58	No	No	0	7	8
542	S:S:A579	S:S:L799	1.58	No	No	0	6	8
543	S:S:A579	S:S:L803	1.58	No	No	0	6	6
544	S:S:P821	S:S:Q820	1.58	No	Yes	0	9	6
545	S:S:E706	S:S:P704	1.57	No	No	0	4	7
546	S:S:I773	S:S:S777	1.55	No	No	0	8	6
547	R:R:I586	R:R:V585	1.54	No	No	0	5	1
548	R:R:I695	R:R:V694	1.54	No	No	0	4	4
549	S:S:A669	S:S:D670	1.54	No	No	0	7	4
550	R:R:M682	R:R:S646	1.53	Yes	No	3	7	9
551	R:R:M830	R:R:S829	1.53	No	No	0	4	5
552	R:R:C535	R:R:E534	1.52	No	No	0	9	4
553	R:R:I567	R:R:T566	1.52	No	No	0	6	7
554	R:R:M682	R:R:V650	1.52	Yes	No	0	7	8
555	R:R:A658	R:R:Q654	1.52	No	No	0	8	8
556	R:R:M748	R:R:V656	1.52	No	No	0	7	7
557	S:S:M689	S:S:V693	1.52	No	No	0	7	4
558	S:S:A797	S:S:Q794	1.52	No	No	0	8	8
559	S:S:A563	S:S:E566	1.51	No	No	0	6	7
560	S:S:F659	S:S:G747	1.51	Yes	No	0	6	7
561	R:R:L734	R:R:S733	1.5	Yes	No	0	8	5
562	R:R:L805	R:R:S804	1.5	No	No	0	2	8
563	S:S:L578	S:S:S577	1.5	No	No	0	4	4
564	S:S:G763	S:S:R762	1.5	No	No	0	5	9
565	R:R:L737	R:R:V740	1.49	No	No	0	4	2
566	S:S:L687	S:S:V691	1.49	No	No	0	3	5
567	S:S:L690	S:S:V693	1.49	No	No	0	4	4
568	S:S:L606	S:S:T650	1.47	No	No	0	8	8
569	S:S:D670	S:S:S673	1.47	No	No	0	4	5
570	S:S:G763	S:S:Y758	1.45	No	No	0	5	9
571	R:R:F665	R:R:P666	1.44	No	No	0	5	7
572	S:S:P625	S:S:R632	1.44	Yes	No	0	7	6
573	R:R:I567	R:R:L571	1.43	No	No	0	6	2
574	R:R:I643	R:R:L639	1.43	No	No	0	7	7
575	S:S:I805	S:S:L648	1.43	No	No	0	7	7
576	S:S:I805	S:S:L806	1.43	No	Yes	0	7	8
577	R:R:L606	R:R:M603	1.41	No	Yes	0	6	8
578	R:R:K760	R:R:N757	1.4	No	No	0	9	9
579	S:S:P812	S:S:Y758	1.39	No	No	0	9	9
580	R:R:L581	R:R:L584	1.38	No	No	0	3	4
581	R:R:L688	R:R:L734	1.38	No	Yes	0	6	8
582	S:S:L622	S:S:L623	1.38	No	No	0	6	5
583	S:S:L623	S:S:L639	1.38	No	No	0	5	6
584	S:S:C801	S:S:Y771	1.34	No	Yes	0	9	8
585	S:S:E566	S:S:L562	1.33	No	No	0	7	8
586	R:R:R725	R:R:S781	1.32	Yes	No	0	2	5
587	S:S:R725	S:S:S726	1.32	No	No	0	6	8
588	S:S:R553	S:S:T552	1.29	No	No	0	2	5
589	R:R:S670	R:R:Y671	1.27	No	No	0	4	5
590	R:R:N726	R:R:R725	1.21	No	Yes	0	2	2
591	R:R:Q592	R:R:R597	1.17	No	No	0	4	7
592	S:S:E549	S:S:R550	1.16	No	No	0	2	4
593	S:S:L683	S:S:W680	1.14	No	No	0	4	7
594	R:R:Q676	R:R:W672	1.1	No	No	0	3	6
595	R:R:R674	R:R:Y675	1.03	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F525	7.474	5	4	7
2	R:R:N527	8.1025	4	0	8
3	R:R:C538	6.695	4	4	9
4	R:R:E542	5.895	4	4	6
5	R:R:W543	8.355	4	0	7
6	R:R:C551	6.265	4	4	9
7	R:R:T580	3.3525	4	13	8
8	R:R:T593	6.165	4	15	9
9	R:R:I595	6.3875	4	0	7
10	R:R:M603	4.9025	4	0	8
11	R:R:M607	3.594	5	14	8
12	R:R:Y615	8.4	4	0	8
13	R:R:V620	3.33	4	0	6
14	R:R:R633	12.8125	4	0	8
15	R:R:Q634	6.555	4	0	8
16	R:R:M661	7.075	4	0	7
17	R:R:M682	2.245	4	3	7
18	R:R:T686	3.4425	4	3	7
19	R:R:D709	10.51	4	5	3
20	R:R:D712	7.9275	4	5	4
21	R:R:I715	8.482	5	5	4
22	R:R:V718	4.05	4	0	7
23	R:R:R725	3.5025	4	0	2
24	R:R:L734	2.816	5	8	8
25	R:R:L738	4.7525	4	3	9
26	R:R:F743	4.8825	4	0	8
27	R:R:Y756	10.262	5	2	9
28	R:R:M780	6.206	5	9	8
29	R:R:D792	3.805	4	9	9
30	R:R:Y807	6.2175	4	14	8
31	R:R:K811	5.055	4	0	9
32	R:R:I815	5.64	4	15	8
33	R:R:F827	6.57	4	2	7
34	S:S:Q543	8.6375	4	10	3
35	S:S:W546	5.314	5	0	7
36	S:S:F561	4.19	4	11	6
37	S:S:S596	3.4775	4	0	9
38	S:S:G604	2.49	4	0	8
39	S:S:L611	4.97	4	0	9
40	S:S:L614	2.8725	4	6	9
41	S:S:F624	10.1025	4	0	7
42	S:S:P625	4.17	4	0	7
43	S:S:P628	6.985	4	11	9
44	S:S:T645	5.6175	4	1	7
45	S:S:F659	4.64	4	0	6
46	S:S:V660	4.8625	4	0	6
47	S:S:E692	5.685	4	1	9
48	S:S:Y699	6.2375	4	0	6
49	S:S:P705	2.86	5	7	8
50	S:S:W711	9.014	5	10	3
51	S:S:H734	7.2825	4	1	7
52	S:S:N737	6.52	4	1	7
53	S:S:F745	6.3075	4	0	9
54	S:S:F749	7.9825	4	0	8
55	S:S:Y771	6.94857	7	1	8
56	S:S:W775	11.115	4	1	9
57	S:S:V779	4.5375	4	0	6
58	S:S:V787	6.125	4	0	7
59	S:S:R790	4.245	4	0	7
60	S:S:M795	3.445	4	0	7
61	S:S:L806	3.294	5	6	8
62	S:S:F809	10.5225	4	0	8
63	S:S:H810	8.38	4	6	9
64	S:S:L817	5.1175	4	18	8
65	S:S:Q820	4.47	4	18	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F525	R:R:N527	11.5117	7.25	Yes	Yes	0	7	8
2	R:R:E542	R:R:N541	20.4921	11.83	Yes	No	0	6	5
3	R:R:K553	R:R:N541	21.0274	6.99	No	No	0	4	5
4	R:R:K553	R:R:Q555	21.5609	8.14	No	No	0	4	3
5	R:R:K714	R:R:Q555	22.0925	8.14	No	No	0	4	3
6	R:R:C551	R:R:E542	10.2787	4.56	Yes	Yes	4	9	6
7	R:R:I715	R:R:K714	22.255	4.36	Yes	No	5	4	4
8	R:R:D709	R:R:I715	28.2202	9.8	Yes	Yes	5	3	4
9	R:R:D709	R:R:V786	34.7335	5.84	Yes	No	0	3	8
10	R:R:I717	R:R:V786	35.2266	4.61	No	No	0	6	8
11	R:R:I717	R:R:R707	35.7178	2.51	No	No	0	6	6
12	R:R:R707	R:R:Y783	36.2071	6.17	No	No	0	6	8
13	R:R:V788	R:R:Y783	37.1804	2.52	No	No	0	7	8
14	R:R:M780	R:R:V788	37.3475	9.13	Yes	No	9	8	7
15	R:R:F779	R:R:M780	42.1843	6.22	No	Yes	0	7	8
16	R:R:F779	R:R:S784	43.1043	5.28	No	No	0	7	6
17	R:R:L787	R:R:S784	43.5615	9.01	No	No	0	5	6
18	R:R:I790	R:R:L787	44.0169	2.85	No	No	0	8	5
19	R:R:I790	R:R:V569	45.3721	3.07	No	No	0	8	8
20	R:R:L793	R:R:V569	46.2664	2.98	No	No	0	8	8
21	R:R:L793	R:R:Y621	29.5855	10.55	No	No	0	8	8
22	R:R:R633	R:R:Y621	29.075	26.75	Yes	No	0	8	8
23	R:R:C720	R:R:R633	21.7353	15.32	No	Yes	0	9	8
24	R:R:C630	R:R:C720	21.1973	7.28	No	No	0	9	9
25	R:R:C630	R:R:Q634	20.6574	3.05	No	Yes	0	9	8
26	R:R:L702	R:R:Q634	11.7697	5.32	No	Yes	0	8	8
27	R:R:L702	R:R:V627	11.1986	2.98	No	No	0	8	4
28	R:R:P704	R:R:V627	10.6257	1.77	No	No	0	6	4
29	R:R:L793	R:R:V618	67.6353	7.45	No	No	0	8	7
30	R:R:V618	R:R:V797	68.3239	3.21	No	No	0	7	9
31	R:R:L572	R:R:V797	69.0052	5.96	No	No	0	3	9
32	R:R:L572	R:R:L801	70.3457	5.54	No	No	0	3	6
33	R:R:L801	R:R:Y615	70.6762	7.03	No	Yes	0	6	8
34	R:R:L800	R:R:Y615	77.7717	11.72	No	Yes	0	8	8
35	R:R:L800	R:R:N799	78.3427	4.12	No	No	0	8	9
36	R:R:F641	R:R:N799	80.2828	10.87	No	No	0	8	9
37	R:R:F641	R:R:Y769	87.1432	9.28	No	No	0	8	8
38	R:R:S739	R:R:Y769	88.2229	7.63	No	No	0	8	8
39	R:R:M766	R:R:S739	88.4323	3.07	No	No	0	9	8
40	R:R:M766	R:R:S765	49.7874	4.6	No	No	0	9	9
41	R:R:I803	R:R:S765	49.3559	3.1	No	No	0	8	9
42	R:R:I648	R:R:I803	47.8814	2.94	No	No	0	7	8
43	R:R:I648	R:R:M607	46.5675	2.92	No	Yes	0	7	8
44	R:R:M607	R:R:Y807	37.4127	3.59	Yes	Yes	14	8	8
45	R:R:K811	R:R:Y807	36.8728	4.78	Yes	Yes	0	9	8
46	R:R:K811	R:R:Y756	26.3224	2.39	Yes	Yes	0	9	9
47	R:R:F641	R:R:I645	15.7159	5.02	No	No	0	8	7
48	R:R:I645	R:R:L738	10.051	7.14	No	Yes	0	7	9
49	R:R:N755	R:R:Y756	11.857	3.49	No	Yes	2	8	9
50	R:R:I655	R:R:N755	11.3107	4.25	No	No	2	9	8
51	R:R:I655	R:R:P753	21.5085	1.69	No	No	0	9	9
52	R:R:G749	R:R:P753	19.2756	4.06	No	No	0	9	9
53	R:R:G749	R:R:M748	18.1564	1.75	No	No	0	9	7
54	R:R:M748	R:R:V656	17.0353	1.52	No	No	0	7	7
55	R:R:K660	R:R:V656	15.9124	3.04	No	No	0	6	7
56	R:R:K660	R:R:M661	14.7877	5.76	No	Yes	0	6	7
57	R:R:E758	R:R:Y756	11.857	25.81	No	Yes	2	9	9
58	R:R:E758	R:R:I655	11.3107	12.3	No	No	2	9	9
59	R:R:F743	R:R:M766	100	7.46	Yes	No	0	8	9
60	R:R:F743	S:S:F749	99.4978	4.29	Yes	Yes	0	8	8
61	S:S:F745	S:S:F749	99.9229	9.65	Yes	Yes	0	9	8
62	S:S:F745	S:S:T765	44.3245	7.78	Yes	No	0	9	9
63	S:S:T748	S:S:T765	43.9434	6.28	No	No	0	9	9
64	S:S:A761	S:S:T748	21.3432	3.36	No	No	0	9	9
65	S:S:A761	S:S:V751	18.1481	3.39	No	No	0	9	8
66	S:S:S662	S:S:V751	17.6091	3.23	No	No	0	9	8
67	S:S:F659	S:S:S662	17.0684	3.96	Yes	No	0	6	9
68	S:S:F745	S:S:F772	73.3958	5.36	Yes	No	0	9	6
69	S:S:F772	S:S:Y771	70.757	4.13	No	Yes	1	6	8
70	S:S:W775	S:S:Y771	36.5872	16.4	Yes	Yes	1	9	8
71	S:S:F778	S:S:W775	34.2561	9.02	No	Yes	0	9	9
72	S:S:F778	S:S:L782	29.2659	6.09	No	No	0	9	8
73	S:S:L782	S:S:R790	28.2321	3.64	No	Yes	0	8	7
74	S:S:R790	S:S:V787	26.6676	5.23	Yes	Yes	0	7	7
75	S:S:Q786	S:S:V787	18.9221	7.16	No	Yes	0	6	7
76	S:S:L714	S:S:Q786	17.2933	3.99	No	No	0	3	6
77	S:S:L714	S:S:P715	16.7452	4.93	No	No	0	3	3
78	S:S:P715	S:S:W546	16.197	4.05	No	Yes	0	3	7
79	S:S:F540	S:S:W546	13.6409	3.01	No	Yes	0	3	7
80	S:S:F540	S:S:S547	13.068	2.64	No	No	0	3	8
81	S:S:C541	S:S:S547	11.3382	6.89	No	No	0	9	8
82	S:S:C541	S:S:C554	10.7579	7.28	No	No	0	9	9
83	S:S:C554	S:S:E545	10.1758	3.04	No	No	0	9	6
84	S:S:N737	S:S:Y771	59.0708	11.63	Yes	Yes	1	7	8
85	S:S:N737	S:S:T645	29.3614	7.31	Yes	Yes	1	7	7
86	S:S:E692	S:S:T645	27.6096	7.06	Yes	Yes	1	9	7
87	S:S:E692	S:S:L642	36.0602	2.65	Yes	No	0	9	7
88	S:S:L642	S:S:P643	32.171	4.93	No	No	0	7	6
89	S:S:P643	S:S:V617	31.194	8.84	No	No	0	6	5
90	S:S:S620	S:S:V617	30.2153	3.23	No	No	0	6	5
91	S:S:S620	S:S:S640	29.2347	4.89	No	No	0	6	7
92	S:S:F624	S:S:S640	25.2463	3.96	Yes	No	0	7	7
93	S:S:F624	S:S:M795	21.3047	2.49	Yes	Yes	0	7	7
94	S:S:M795	S:S:P625	17.3089	6.71	Yes	Yes	0	7	7
95	S:S:N737	S:S:T736	27.8933	4.39	Yes	No	1	7	8
96	S:S:E692	S:S:T736	27.4554	8.47	Yes	No	1	9	8
97	S:S:L764	S:S:T748	27.729	2.95	No	No	0	9	9
98	S:S:L651	S:S:L764	27.2782	4.15	No	No	0	7	9
99	S:S:F809	S:S:L651	26.9348	10.96	Yes	No	0	8	7
100	S:S:F809	S:S:H810	24.1923	18.1	Yes	Yes	0	8	9
101	S:S:H810	S:S:L806	13.023	5.14	Yes	Yes	6	9	8
102	S:S:L644	S:S:N737	18.5649	2.75	No	Yes	0	8	7
103	S:S:L644	S:S:L648	18.1141	2.77	No	No	0	8	7
104	S:S:I805	S:S:L648	17.6964	1.43	No	No	0	7	7
105	S:S:I805	S:S:L806	17.3163	1.43	No	Yes	0	7	8
106	S:S:H810	S:S:L611	17.6174	7.71	Yes	Yes	0	9	9
107	S:S:F590	S:S:L611	14.3451	4.87	No	Yes	0	9	9
108	S:S:A607	S:S:F590	12.1269	2.77	No	No	0	8	9
109	S:S:A607	S:S:G604	11.5677	1.95	No	Yes	0	8	8
110	S:S:C696	S:S:E692	19.3279	4.56	No	Yes	0	7	9
111	S:S:C696	S:S:P638	18.3271	3.77	No	No	0	7	5
112	S:S:P638	S:S:Y699	17.3245	6.95	No	Yes	0	5	6
113	S:S:F659	S:S:L664	12.6842	6.09	Yes	No	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9UTA

PDB Summary
PDB	9UTA
Class	C
SubFamily	Sensory
Type	Taste1
SubType	TAS1R2; TAS1R3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.77
Date	2025-07-16
D.O.I.	doi.org/10.1038/s41586-025-09302-6

Net Summary
I_min	2.51
Number of Linked Nodes	553
Number of Links	595
Number of Hubs	65
Number of Links mediated by Hubs	233
Number of Communities	18
Number of Nodes involved in Communities	79
Number of Links involved in Communities	96

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	208193
Length Of Smallest Path	3
Average Path Length	25.2696
Length of Longest Path	63
Minimum Path Strength	1.265
Average Path Strength	5.95565
Maximum Path Strength	21.17
Minimum Path Correlation	0.7
Average Path Correlation	0.971071
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.32558
Average % Of Corr. Nodes	49.4738
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.7594
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• sensory perception of sweet taste • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory perception of umami taste • response to stimulus • detection of chemical stimulus involved in sensory perception of sweet taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • response to chemical • detection of chemical stimulus • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • protein-containing complex • taste receptor complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • cell periphery • plasma membrane • protein-containing complex • taste receptor complex • sweet taste receptor complex • receptor complex • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled receptor activity • sweet taste receptor activity • sensory perception of sweet taste • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • response to stimulus • detection of chemical stimulus involved in sensory perception of sweet taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • response to chemical • detection of chemical stimulus • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TE23
Sequence	>9UTA_Chain_R I D C L P G T F L N H T E D E Y E C Q A C P N N E W S Y Q S E T S C F K R Q L V F L E W H E A P T I A V A L L A A L G F L S T L A I L V I F W R H F Q T P I V R S A G G P M C F L M L T L L L V A Y M V V P V Y V G P P K V S T C L C R Q A L F P L C F T I C I S C I A V R S F Q I V C A F K M A S R F P R A Y S Y W V R Y Q G P Y V S M A F I T V L K M V I V V I G M L A T G L S P T T R T D P D D P K I T I V S C N P N Y R N S L L F N T S L D L L L S V V G F S F A Y M G K E L P T N Y N E A K F I T L S M T F Y F T S S V S L C T F M S A Y S G V L V T I V D L L V T V L N L L A I S L G Y F G P K C Y M I L F Y P E R N T P A Y F N S M I Q G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	S
Protein	Receptor
UniProt	Q7RTX0
Sequence	>9UTA_Chain_S T F C G Q D E W S P E R S T R C F R R R S R F L A W G E P A V L L L L L L L S L A L G L V L A A L G L F V H H R D S P L V Q A S G G P L A C F G L V C L G L V C L S V L L F P G Q P S P A R C L A Q Q P L S H L P L T G C L S T L F L Q A A E I F V E S E L P L S W A D R L S G C L R G P W A W L V V L L A M L V E V A L C T W Y L V A F P P E V V T D W H M L P T E A L V H C R T R S W V S F G L A H A T N A T L A F L C F L G T F L V R S Q P G C Y N R A R G L T F A M L A Y F I T W V S F V P L L A N V Q V V L R P A V Q M G A L L L C V L G I L A A F H L P R C Y L L M R Q P G L N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9NOX	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOX (No Gprot)	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOY	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	-	3.7	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOR	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.4	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOS	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.5	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOT	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.8	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38 (No Gprot)	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9OQ0	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens; mus musculus	-	-	-	3.67	2025-08-27	To be published
	9UT8	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.41	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTA	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.77	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTB	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	Sucralose	-	-	3.59	2025-07-16	doi.org/10.1038/s41586-025-09302-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9UTA.zip

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