psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L559	R:R:V622	4.47	No	No	0	8	7
2	R:R:I790	R:R:L559	2.85	Yes	No	0	8	8
3	R:R:V622	R:R:W561	12.26	No	No	0	7	5
4	R:R:E563	R:R:P565	14.15	No	No	0	8	6
5	R:R:E563	R:R:T566	7.06	No	No	0	8	7
6	R:R:I567	R:R:T566	4.56	No	No	0	6	7
7	R:R:I790	R:R:T566	3.04	Yes	No	0	8	7
8	R:R:L793	R:R:V569	4.47	No	No	0	8	8
9	R:R:L794	R:R:V569	4.47	No	No	0	7	8
10	R:R:V569	R:R:V797	3.21	No	No	0	8	9
11	R:R:L572	R:R:V797	2.98	No	No	0	3	9
12	R:R:L572	R:R:L801	4.15	No	No	0	3	6
13	R:R:A573	R:R:V618	5.09	No	Yes	0	7	7
14	R:R:G576	R:R:Y615	2.9	No	Yes	0	6	8
15	R:R:F577	R:R:L612	7.31	No	No	0	6	4
16	R:R:F577	R:R:M616	4.98	No	No	0	6	6
17	R:R:L805	R:R:S579	3	No	No	0	2	4
18	R:R:L612	R:R:T580	2.95	No	No	0	4	8
19	R:R:T580	R:R:Y615	6.24	No	Yes	0	8	8
20	R:R:I583	R:R:L608	5.71	No	No	3	7	9
21	R:R:F808	R:R:I583	6.28	Yes	No	3	9	7
22	R:R:C812	R:R:I583	4.91	No	No	0	7	7
23	R:R:L584	R:R:L608	8.3	No	No	0	4	9
24	R:R:L584	R:R:T609	2.95	No	No	0	4	4
25	R:R:I586	R:R:I815	2.94	No	Yes	2	5	8
26	R:R:I586	R:R:L816	7.14	No	No	2	5	6
27	R:R:F587	R:R:V596	5.24	No	Yes	0	9	9
28	R:R:F587	R:R:F808	4.29	No	Yes	0	9	9
29	R:R:F605	R:R:W588	3.01	No	No	0	6	5
30	R:R:H590	R:R:R589	10.16	No	No	0	5	4
31	R:R:F591	R:R:V596	7.87	No	Yes	0	5	9
32	R:R:P594	R:R:T593	5.25	No	Yes	0	8	9
33	R:R:I595	R:R:T593	4.56	Yes	Yes	2	7	9
34	R:R:T593	R:R:V596	3.17	Yes	Yes	0	9	9
35	R:R:N822	R:R:T593	13.16	No	Yes	2	9	9
36	R:R:P594	R:R:P824	9.74	No	No	0	8	6
37	R:R:F827	R:R:P594	14.45	Yes	No	0	7	8
38	R:R:I595	R:R:K811	7.27	Yes	No	0	7	9
39	R:R:I595	R:R:I815	8.83	Yes	Yes	2	7	8
40	R:R:I595	R:R:N822	8.5	Yes	No	2	7	9
41	R:R:S598	R:R:Y756	5.09	No	Yes	1	9	9
42	R:R:F827	R:R:S598	5.28	Yes	No	1	7	9
43	R:R:A599	R:R:K811	3.21	No	No	0	9	9
44	R:R:G600	R:R:M603	3.49	No	No	0	9	8
45	R:R:G601	R:R:P602	4.06	No	No	0	8	6
46	R:R:C647	R:R:M603	6.48	No	No	0	7	8
47	R:R:C604	R:R:F808	5.59	No	Yes	0	9	9
48	R:R:C644	R:R:M607	3.24	No	Yes	0	7	8
49	R:R:C647	R:R:M607	3.24	No	Yes	0	7	8
50	R:R:I648	R:R:M607	4.37	No	Yes	0	7	8
51	R:R:F808	R:R:M607	3.73	Yes	Yes	0	9	8
52	R:R:F808	R:R:L608	14.61	Yes	No	3	9	9
53	R:R:C640	R:R:L610	3.17	Yes	No	0	7	8
54	R:R:I643	R:R:L610	4.28	Yes	No	0	7	8
55	R:R:C640	R:R:L611	3.17	Yes	No	0	7	9
56	R:R:M616	R:R:V613	3.04	No	No	0	6	6
57	R:R:L636	R:R:V613	2.98	No	No	0	6	6
58	R:R:A614	R:R:C640	3.61	No	Yes	0	6	7
59	R:R:L800	R:R:Y615	7.03	No	Yes	0	8	8
60	R:R:S804	R:R:Y615	3.82	No	Yes	0	8	8
61	R:R:C632	R:R:V617	3.42	No	No	4	6	6
62	R:R:L636	R:R:V617	8.94	No	No	4	6	6
63	R:R:P619	R:R:V618	3.53	No	Yes	0	6	7
64	R:R:F637	R:R:V618	3.93	No	Yes	0	8	7
65	R:R:V618	R:R:V797	3.21	Yes	No	0	7	9
66	R:R:T629	R:R:V620	3.17	No	No	0	6	6
67	R:R:R633	R:R:Y621	19.55	No	No	0	8	8
68	R:R:F637	R:R:Y621	9.28	No	No	0	8	8
69	R:R:L793	R:R:Y621	9.38	No	No	0	8	8
70	R:R:G623	R:R:P624	4.06	No	No	0	8	5
71	R:R:K626	R:R:S628	3.06	No	No	0	5	4
72	R:R:K626	R:R:T629	6.01	No	No	0	5	6
73	R:R:C632	R:R:L636	3.17	No	No	4	6	6
74	R:R:D792	R:R:R633	3.57	No	No	0	9	8
75	R:R:K689	R:R:P638	3.35	Yes	No	0	9	5
76	R:R:I643	R:R:L639	4.28	Yes	No	0	7	7
77	R:R:C640	R:R:L800	3.17	Yes	No	0	7	8
78	R:R:D735	R:R:F641	3.58	No	Yes	5	8	8
79	R:R:F641	R:R:Y769	11.35	Yes	Yes	5	8	8
80	R:R:F641	R:R:T796	5.19	Yes	No	0	8	8
81	R:R:F641	R:R:L800	6.09	Yes	No	0	8	8
82	R:R:I643	R:R:T642	3.04	Yes	No	0	7	8
83	R:R:K689	R:R:T642	18.02	Yes	No	0	9	8
84	R:R:I643	R:R:T686	3.04	Yes	No	0	7	7
85	R:R:C644	R:R:I803	3.27	No	No	0	7	8
86	R:R:D735	R:R:I645	8.4	No	No	0	8	7
87	R:R:I685	R:R:S646	6.19	No	No	0	5	9
88	R:R:C647	R:R:M682	3.24	No	No	0	7	7
89	R:R:I648	R:R:Y807	8.46	No	Yes	0	7	8
90	R:R:Q654	R:R:V650	2.87	No	No	0	8	8
91	R:R:I655	R:R:R651	3.76	No	No	0	9	9
92	R:R:E758	R:R:R651	6.98	No	No	0	9	9
93	R:R:R651	R:R:Y807	7.2	No	Yes	0	9	8
94	R:R:F653	R:R:W672	17.04	No	Yes	0	7	6
95	R:R:F653	R:R:F745	9.65	No	No	0	7	7
96	R:R:P678	R:R:Q654	11.05	Yes	No	0	8	8
97	R:R:I655	R:R:Y756	6.04	No	Yes	0	9	9
98	R:R:F745	R:R:V656	3.93	No	No	0	7	7
99	R:R:M748	R:R:V656	4.56	No	No	0	7	7
100	R:R:C657	R:R:Y669	4.03	No	No	0	6	7
101	R:R:F659	R:R:L752	4.87	Yes	Yes	1	9	8
102	R:R:F659	R:R:P753	7.22	Yes	Yes	1	9	9
103	R:R:F659	R:R:Y756	9.28	Yes	Yes	1	9	9
104	R:R:F659	R:R:Y834	6.19	Yes	Yes	1	9	6
105	R:R:K660	R:R:M748	4.32	No	No	0	6	7
106	R:R:E751	R:R:K660	6.75	No	No	0	7	6
107	R:R:M661	R:R:R664	4.96	No	No	0	7	7
108	R:R:F665	R:R:R664	6.41	No	No	0	5	7
109	R:R:A668	R:R:R667	4.15	No	No	0	5	5
110	R:R:R667	R:R:Y671	7.2	No	No	0	5	5
111	R:R:G677	R:R:W672	8.44	No	Yes	6	8	6
112	R:R:P678	R:R:W672	13.51	Yes	Yes	6	8	6
113	R:R:S681	R:R:W672	3.71	No	Yes	0	7	6
114	R:R:R674	R:R:Y675	13.38	No	No	0	7	6
115	R:R:G677	R:R:P678	4.06	No	Yes	6	8	8
116	R:R:F684	R:R:L688	4.87	No	No	0	3	6
117	R:R:I685	R:R:L738	5.71	No	No	0	5	9
118	R:R:K689	R:R:V693	4.55	Yes	No	0	9	7
119	R:R:K689	R:R:N731	4.2	Yes	No	0	9	7
120	R:R:M690	R:R:V693	3.04	No	No	0	4	7
121	R:R:I692	R:R:I695	2.94	No	Yes	0	6	4
122	R:R:F730	R:R:I692	3.77	No	No	0	4	6
123	R:R:M697	R:R:V694	3.04	No	No	0	7	4
124	R:R:M780	R:R:Y724	3.59	No	No	0	8	8
125	R:R:R725	R:R:S781	6.59	No	No	0	2	5
126	R:R:L728	R:R:T732	4.42	No	No	0	7	7
127	R:R:L729	R:R:T732	2.95	No	No	0	5	7
128	R:R:C777	R:R:L729	3.17	No	No	0	7	5
129	R:R:S773	R:R:T732	6.4	No	No	0	9	7
130	R:R:D735	R:R:Y769	12.64	No	Yes	5	8	8
131	R:R:F770	R:R:L736	12.18	No	No	0	6	6
132	R:R:M766	R:R:S739	6.13	No	No	0	9	8
133	R:R:G742	R:R:V741	3.68	No	Yes	0	9	4
134	R:R:F743	R:R:I762	3.77	Yes	No	0	8	9
135	R:R:F743	R:R:T763	3.89	Yes	No	0	8	9
136	R:R:F743	R:R:M766	7.46	Yes	No	0	8	9
137	R:R:K750	R:R:Y747	13.14	No	No	0	9	8
138	R:R:G749	R:R:L752	5.13	No	Yes	0	9	8
139	R:R:E751	R:R:Y834	10.1	No	Yes	0	7	6
140	R:R:L752	R:R:P753	3.28	Yes	Yes	1	8	9
141	R:R:L752	R:R:Y834	4.69	Yes	Yes	1	8	6
142	R:R:M830	R:R:P753	3.35	Yes	Yes	0	4	9
143	R:R:P753	R:R:Y834	15.3	Yes	Yes	1	9	6
144	R:R:N755	R:R:T754	5.85	No	No	0	8	7
145	R:R:F827	R:R:N755	10.87	Yes	No	0	7	8
146	R:R:M830	R:R:N755	5.61	Yes	No	0	4	8
147	R:R:F827	R:R:Y756	6.19	Yes	Yes	1	7	9
148	R:R:I831	R:R:Y756	4.84	No	Yes	0	7	9
149	R:R:A759	R:R:N757	3.13	No	No	0	9	9
150	R:R:E758	R:R:F761	4.66	No	Yes	0	9	5
151	R:R:F761	R:R:S765	5.28	Yes	No	0	5	9
152	R:R:F761	R:R:I803	3.77	Yes	No	0	5	8
153	R:R:F761	R:R:Y807	12.38	Yes	Yes	0	5	8
154	R:R:F768	R:R:S772	3.96	No	No	0	7	9
155	R:R:S773	R:R:Y769	3.82	No	Yes	0	9	8
156	R:R:N799	R:R:Y769	9.3	No	Yes	0	9	8
157	R:R:S772	R:R:V795	3.23	No	No	0	9	8
158	R:R:N799	R:R:S772	2.98	No	No	0	9	9
159	R:R:L776	R:R:M780	5.65	No	No	0	9	8
160	R:R:D792	R:R:L776	6.79	No	No	0	9	9
161	R:R:L776	R:R:V795	4.47	No	No	0	9	8
162	R:R:M780	R:R:V788	4.56	No	No	0	8	7
163	R:R:S784	R:R:Y783	6.36	No	No	0	6	8
164	R:R:V788	R:R:Y783	6.31	No	No	0	7	8
165	R:R:S784	R:R:V786	3.23	No	No	0	6	8
166	R:R:L787	R:R:V786	5.96	No	No	0	5	8
167	R:R:I790	R:R:L787	4.28	Yes	No	0	8	5
168	R:R:L793	R:R:T796	4.42	No	No	0	8	8
169	R:R:I803	R:R:N799	2.83	No	No	0	8	9
170	R:R:L805	R:R:S804	4.5	No	No	0	2	8
171	R:R:F808	R:R:Y807	11.35	Yes	Yes	0	9	8
172	R:R:K811	R:R:Y807	13.14	No	Yes	0	9	8
173	R:R:G809	R:R:P810	4.06	No	No	0	3	9
174	R:R:F817	R:R:Y813	9.28	No	No	0	5	8
175	R:R:Y813	R:R:Y818	2.98	No	Yes	0	8	6
176	R:R:I815	R:R:L816	2.85	Yes	No	2	8	6
177	R:R:I815	R:R:N822	7.08	Yes	No	2	8	9
178	R:R:R821	R:R:Y818	11.32	No	Yes	0	5	6
179	R:R:R821	R:R:Y826	11.32	No	No	0	5	5
180	R:R:P824	R:R:T823	3.5	No	No	0	6	7
181	R:R:M830	R:R:Y826	9.58	Yes	No	0	4	5
182	R:R:M836	R:R:Q832	4.08	No	No	0	7	8
183	R:R:T835	R:R:Y834	3.75	No	Yes	0	7	6
184	R:R:R837	R:R:Y834	7.2	No	Yes	0	7	6
185	R:R:K689	R:R:L734	2.82	Yes	No	0	9	8
186	R:R:K760	R:R:L764	2.82	No	No	0	9	9
187	R:R:C657	R:R:F653	2.79	No	No	0	6	7
188	R:R:A668	R:R:F665	2.77	No	No	0	5	5
189	R:R:L688	R:R:L734	2.77	No	No	0	6	8
190	R:R:A802	R:R:F768	2.77	No	No	0	7	7
191	R:R:L794	R:R:L798	2.77	No	No	0	7	7
192	R:R:H590	R:R:I586	2.65	No	No	0	5	5
193	R:R:F770	R:R:V774	2.62	No	No	0	6	6
194	R:R:F779	R:R:T778	2.59	No	No	0	7	8
195	R:R:F605	R:R:L584	2.44	No	No	0	6	4
196	R:R:M814	R:R:Y818	2.39	No	Yes	0	8	6
197	R:R:D839	R:R:R837	2.38	No	No	0	5	7
198	R:R:Q676	R:R:Y679	2.25	No	No	0	3	5
199	R:R:G600	R:R:G601	2.11	No	No	0	9	8
200	R:R:R674	R:R:Y671	2.06	No	No	0	7	5
201	R:R:F743	R:R:Y747	2.06	Yes	No	0	8	8
202	R:R:P624	R:R:P625	1.95	No	No	0	5	9
203	R:R:A649	R:R:G742	1.95	No	No	0	8	9
204	R:R:A564	R:R:P565	1.87	No	No	0	4	6
205	R:R:G785	R:R:S784	1.86	No	No	0	7	6
206	R:R:G623	R:R:V622	1.84	No	No	0	8	7
207	R:R:G677	R:R:V680	1.84	No	No	0	8	4
208	R:R:G696	R:R:I695	1.76	No	Yes	0	7	4
209	R:R:G576	R:R:L575	1.71	No	No	0	6	2
210	R:R:A746	R:R:S652	1.71	No	No	0	9	9
211	R:R:G806	R:R:L805	1.71	No	No	0	6	2
212	R:R:A825	R:R:T823	1.68	No	No	0	6	7
213	R:R:G833	R:R:Q832	1.64	No	No	0	4	8
214	R:R:S739	R:R:S765	1.63	No	No	0	8	9
215	R:R:S744	R:R:V741	1.62	No	Yes	0	4	4
216	R:R:V791	R:R:V795	1.6	No	No	0	7	8
217	R:R:T778	R:R:V774	1.59	No	No	0	8	6
218	R:R:A635	R:R:L631	1.58	No	No	0	5	5
219	R:R:P638	R:R:Q634	1.58	No	No	0	5	8
220	R:R:I695	R:R:V691	1.54	Yes	No	0	4	3
221	R:R:I695	R:R:V694	1.54	Yes	No	0	4	4
222	R:R:C630	R:R:Q634	1.53	No	No	0	9	8
223	R:R:M830	R:R:S829	1.53	Yes	No	0	4	5
224	R:R:I685	R:R:T642	1.52	No	No	0	5	8
225	R:R:M661	R:R:V656	1.52	No	No	0	7	7
226	R:R:M690	R:R:V694	1.52	No	No	0	4	4
227	R:R:M697	R:R:V693	1.52	No	No	0	7	7
228	R:R:M766	R:R:V740	1.52	No	No	0	9	2
229	R:R:I790	R:R:T789	1.52	Yes	No	0	8	7
230	R:R:L728	R:R:S727	1.5	No	No	0	7	6
231	R:R:L581	R:R:V585	1.49	No	No	0	3	1
232	R:R:L737	R:R:V741	1.49	No	Yes	0	4	4
233	R:R:F665	R:R:P666	1.44	No	No	0	5	7
234	R:R:I643	R:R:L606	1.43	Yes	No	0	7	6
235	R:R:L631	R:R:M697	1.41	No	No	0	5	7
236	R:R:P678	R:R:Y679	1.39	Yes	No	0	8	5
237	R:R:P819	R:R:Y818	1.39	No	Yes	0	8	6
238	R:R:L581	R:R:L612	1.38	No	No	0	3	4
239	R:R:L752	R:R:N757	1.37	Yes	No	0	8	9
240	R:R:R597	R:R:V596	1.31	No	Yes	0	7	9
241	R:R:F745	R:R:V741	1.31	No	Yes	0	7	4
242	R:R:F768	R:R:T771	1.3	No	No	0	7	8
243	R:R:S670	R:R:Y671	1.27	No	No	0	4	5
244	R:R:L729	R:R:R725	1.21	No	No	0	5	2
245	R:R:D839	R:R:R838	1.19	No	No	0	5	4
246	R:R:F591	R:R:Q592	1.17	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T593	6.535	4	2	9
2	R:R:I595	7.29	4	2	7
3	R:R:V596	4.3975	4	0	9
4	R:R:M607	3.645	4	0	8
5	R:R:Y615	4.9975	4	0	8
6	R:R:V618	3.94	4	0	7
7	R:R:C640	3.28	4	0	7
8	R:R:F641	6.5525	4	5	8
9	R:R:I643	3.214	5	0	7
10	R:R:F659	6.89	4	1	9
11	R:R:W672	10.675	4	6	6
12	R:R:P678	7.5025	4	6	8
13	R:R:K689	6.588	5	0	9
14	R:R:I695	1.945	4	0	4
15	R:R:V741	2.025	4	0	4
16	R:R:F743	4.295	4	0	8
17	R:R:L752	3.868	5	1	8
18	R:R:P753	7.2875	4	1	9
19	R:R:Y756	6.288	5	1	9
20	R:R:F761	6.5225	4	0	5
21	R:R:Y769	9.2775	4	5	8
22	R:R:I790	2.9225	4	0	8
23	R:R:Y807	10.506	5	0	8
24	R:R:F808	7.64167	6	3	9
25	R:R:I815	5.425	4	2	8
26	R:R:Y818	4.52	4	0	6
27	R:R:F827	9.1975	4	1	7
28	R:R:M830	5.0175	4	0	4
29	R:R:Y834	7.87167	6	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I790	R:R:L787	17.2684	4.28	Yes	No	0	8	5
2	R:R:L787	R:R:V786	18.5358	5.96	No	No	0	5	8
3	R:R:S784	R:R:V786	19.7946	3.23	No	No	0	6	8
4	R:R:S784	R:R:Y783	22.2858	6.36	No	No	0	6	8
5	R:R:V788	R:R:Y783	23.514	6.31	No	No	0	7	8
6	R:R:M780	R:R:V788	24.5935	4.56	No	No	0	8	7
7	R:R:L776	R:R:M780	27.0192	5.65	No	No	0	9	8
8	R:R:L793	R:R:V569	11.2107	4.47	No	No	0	8	8
9	R:R:L800	R:R:Y615	22.2858	7.03	No	Yes	0	8	8
10	R:R:F641	R:R:L800	62.6705	6.09	Yes	No	0	8	8
11	R:R:F641	R:R:Y769	73.2955	11.35	Yes	Yes	5	8	8
12	R:R:N799	R:R:Y769	81.6259	9.3	No	Yes	0	9	8
13	R:R:N799	R:R:S772	34.7465	2.98	No	No	0	9	9
14	R:R:S772	R:R:V795	30.5332	3.23	No	No	0	9	8
15	R:R:L776	R:R:V795	28.4572	4.47	No	No	0	9	8
16	R:R:L612	R:R:T580	12.111	2.95	No	No	0	4	8
17	R:R:T580	R:R:Y615	13.4135	6.24	No	Yes	0	8	8
18	R:R:F808	R:R:M607	11.3024	3.73	Yes	Yes	0	9	8
19	R:R:C644	R:R:M607	12.2159	3.24	No	Yes	0	7	8
20	R:R:C644	R:R:I803	12.5481	3.27	No	No	0	7	8
21	R:R:I803	R:R:N799	100	2.83	No	No	0	8	9
22	R:R:F808	R:R:Y807	14.2439	11.35	Yes	Yes	0	9	8
23	R:R:F761	R:R:Y807	54.5848	12.38	Yes	Yes	0	5	8
24	R:R:F761	R:R:I803	89.8951	3.77	Yes	No	0	5	8
25	R:R:F827	R:R:Y756	19.2701	6.19	Yes	Yes	1	7	9
26	R:R:I655	R:R:Y756	82.0979	6.04	No	Yes	0	9	9
27	R:R:I655	R:R:R651	83.0682	3.76	No	No	0	9	9
28	R:R:E758	R:R:R651	38.0157	6.98	No	No	0	9	9
29	R:R:E758	R:R:F761	38.278	4.66	No	Yes	0	9	5
30	R:R:R651	R:R:Y807	46.3549	7.2	No	Yes	0	9	8
31	R:R:C640	R:R:L800	44.9694	3.17	Yes	No	0	7	8
32	R:R:C640	R:R:L610	41.7439	3.17	Yes	No	0	7	8
33	R:R:I643	R:R:L610	40.6512	4.28	Yes	No	0	7	8
34	R:R:K689	R:R:T642	31.5953	18.02	Yes	No	0	9	8
35	R:R:I643	R:R:T642	36.1932	3.04	Yes	No	0	7	8
36	R:R:L793	R:R:T796	17.9939	4.42	No	No	0	8	8
37	R:R:F659	R:R:Y756	68.6407	9.28	Yes	Yes	1	9	9
38	R:R:F659	R:R:Y834	49.6066	6.19	Yes	Yes	1	9	6
39	R:R:E751	R:R:Y834	45.9135	10.1	No	Yes	0	7	6
40	R:R:E751	R:R:K660	44.7246	6.75	No	No	0	7	6
41	R:R:K660	R:R:M748	43.4091	4.32	No	No	0	6	7
42	R:R:M748	R:R:V656	42.076	4.56	No	No	0	7	7
43	R:R:F745	R:R:V656	26.7745	3.93	No	No	0	7	7
44	R:R:F653	R:R:F745	17.9895	9.65	No	No	0	7	7
45	R:R:F653	R:R:W672	13.5752	17.04	No	Yes	0	7	6
46	R:R:F659	R:R:P753	12.4563	7.22	Yes	Yes	1	9	9
47	R:R:M661	R:R:V656	15.4983	1.52	No	No	0	7	7
48	R:R:M661	R:R:R664	13.9991	4.96	No	No	0	7	7
49	R:R:F665	R:R:R664	12.4781	6.41	No	No	0	5	7
50	R:R:K689	R:R:V693	22.1285	4.55	Yes	No	0	9	7
51	R:R:I695	R:R:V694	13.2605	1.54	Yes	No	0	4	4
52	R:R:M697	R:R:V693	11.6914	1.52	No	No	0	7	7
53	R:R:S773	R:R:Y769	10.7998	3.82	No	Yes	0	9	8
54	R:R:F761	R:R:S765	12.0717	5.28	Yes	No	0	5	9
55	R:R:S739	R:R:S765	10.7649	1.63	No	No	0	8	9
56	R:R:M830	R:R:P753	13.3348	3.35	Yes	Yes	0	4	9
57	R:R:F827	R:R:N755	15.7998	10.87	Yes	No	0	7	8
58	R:R:M830	R:R:N755	13.4091	5.61	Yes	No	0	4	8
59	R:R:R821	R:R:Y818	14.4187	11.32	No	Yes	0	5	6
60	R:R:R821	R:R:Y826	17.2771	11.32	No	No	0	5	5
61	R:R:M830	R:R:Y826	20.1267	9.58	Yes	No	0	4	5
62	R:R:F641	R:R:T796	19.0647	5.19	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9NOX_nogp

PDB Summary
PDB	9NOX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	233
Number of Links	246
Number of Hubs	29
Number of Links mediated by Hubs	108
Number of Communities	6
Number of Nodes involved in Communities	25
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	37489
Length Of Smallest Path	3
Average Path Length	16.1695
Length of Longest Path	36
Minimum Path Strength	1.4
Average Path Strength	5.94128
Maximum Path Strength	13.4
Minimum Path Correlation	0.7
Average Path Correlation	0.926331
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	42.6579
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7739
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• sensory perception of sweet taste • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • response to stimulus • detection of chemical stimulus involved in sensory perception of sweet taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • response to chemical • detection of chemical stimulus • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein-containing complex • receptor complex • cellular anatomical structure • membrane • cell periphery • plasma membrane • taste receptor complex • sweet taste receptor complex • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled receptor activity • sensory perception of umami taste • Golgi apparatus • endomembrane system
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TE23
Sequence	>9NOX_nogp_Chain_R L E W H E A P T I A V A L L A A L G F L S T L A I L V I F W R H F Q T P I V R S A G G P M C F L M L T L L L V A Y M V V P V Y V G P P K V S T C L C R Q A L F P L C F T I C I S C I A V R S F Q I V C A F K M A S R F P R A Y S Y W V R Y Q G P Y V S M A F I T V L K M V I V V I G M L A Y R N S L L F N T S L D L L L S V V G F S F A Y M G K E L P T N Y N E A K F I T L S M T F Y F T S S V S L C T F M S A Y S G V L V T I V D L L V T V L N L L A I S L G Y F G P K C Y M I L F Y P E R N T P A Y F N S M I Q G Y T M R R D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9NOX	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOX (No Gprot)	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOY	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	-	3.7	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOR	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.4	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOS	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.5	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOT	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.8	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38 (No Gprot)	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9OQ0	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens; mus musculus	-	-	-	3.67	2025-08-27	To be published
	9UT8	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.41	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTA	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.77	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTB	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	Sucralose	-	-	3.59	2025-07-16	doi.org/10.1038/s41586-025-09302-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9NOX_nogp.zip

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