Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.825414
2A:A:H41 6.8675486
3A:A:L44 9.195419
4A:A:S51 5409
5A:A:I207 5.7875419
6A:A:F212 6.4825489
7A:A:F219 6.06688
8A:A:H220 8.2575417
9A:A:F222 7.58517
10A:A:Q227 6.9275419
11A:A:R228 6.935409
12A:A:R232 8.1625418
13A:A:K233 5.34714719
14A:A:W234 6.85833619
15A:A:F238 7.65143719
16A:A:D249 7.58254118
17A:A:D252 6.44254118
18A:A:Y253 7.28408
19A:A:R265 5.3225119
20A:A:F273 5.198579
21A:A:W277 10.268576
22A:A:W281 10.324515
23A:A:N292 5.0425409
24A:A:L296 4.225406
25A:A:F315 10.832546
26A:A:Y318 6.546546
27A:A:P321 4.77545
28A:A:V334 4.1775404
29A:A:Y339 7.656543
30A:A:F340 11.5225447
31A:A:R342 7.686544
32A:A:F345 7.664578
33A:A:Y360 6.72667628
34A:A:F363 9.922545
35A:A:D381 9.0525428
36A:A:K385 9.9325425
37A:A:F394 6.01286725
38B:B:L4 3.035404
39B:B:L7 4.53408
40B:B:R22 5.32416
41B:B:V40 4.6145123
42B:B:L51 7.89469
43B:B:H54 8.00333669
44B:B:K57 11.224519
45B:B:Y59 7.3125418
46B:B:W63 5.90167607
47B:B:V71 4.31754138
48B:B:Q75 10.7775419
49B:B:D76 6.076519
50B:B:K78 5.7775408
51B:B:I81 4.40254137
52B:B:W82 8.25286769
53B:B:D83 10.41754108
54B:B:T86 7.94106
55B:B:N88 6.8254107
56B:B:K89 5.85667669
57B:B:I93 6.4725407
58B:B:L95 4.5365148
59B:B:W99 7.44143719
60B:B:Y105 4.235717136
61B:B:N110 6.8525414
62B:B:Y111 6.99414
63B:B:L117 4.916519
64B:B:Y124 6.2425146
65B:B:H142 7.11667619
66B:B:Y145 6.93857718
67B:B:L146 4.0875417
68B:B:F151 4.55571719
69B:B:L152 5.2925403
70B:B:I157 4.6875417
71B:B:T159 5.326519
72B:B:D163 9.7875419
73B:B:W169 8.75667618
74B:B:F180 8.144537
75B:B:H183 7.725639
76B:B:D186 7.015419
77B:B:V187 4.766539
78B:B:L190 5.0025435
79B:B:F199 7.572539
80B:B:V200 5.6025416
81B:B:S201 4.915439
82B:B:C204 4.44667617
83B:B:D205 6.6775439
84B:B:K209 10.24536
85B:B:W211 8.30333638
86B:B:D212 8.29754189
87B:B:Q220 8.0475417
88B:B:F222 7.594518
89B:B:H225 8.45833619
90B:B:D228 8.068519
91B:B:I232 5.4775418
92B:B:F234 5.08405
93B:B:F235 6.656596
94B:B:P236 6.725497
95B:B:F241 6.632516
96B:B:D246 4.8225419
97B:B:D247 7.644519
98B:B:T249 7.8625416
99B:B:R251 7.75286718
100B:B:F253 7.235616
101B:B:D258 8.6275417
102B:B:M262 5.4825404
103B:B:Y264 6.176505
104B:B:H266 8.445414
105B:B:I269 3.2475414
106B:B:F278 6.14167697
107B:B:R283 8.1145129
108B:B:Y289 6.69717
109B:B:D290 6.3525416
110B:B:W297 5.2325418
111B:B:K301 7.1475405
112B:B:R304 5.772515
113B:B:H311 7.95659
114B:B:R314 8.60167618
115B:B:W332 9.87857719
116B:B:D333 8.3625459
117B:B:L336 4.51467
118B:B:K337 7.3625456
119B:B:W339 8.43833659
120G:G:R27 5.49518
121G:G:Y40 11.1975496
122G:G:D48 8.0275409
123G:G:L51 4.8825126
124R:R:T593 6.5354159
125R:R:I595 7.294157
126R:R:M607 3.645408
127R:R:Y615 4.9975408
128R:R:V618 3.94407
129R:R:C640 3.28407
130R:R:F641 6.55254228
131R:R:I643 3.214507
132R:R:F659 6.64833629
133R:R:W672 10.6754236
134R:R:P678 7.50254238
135R:R:K689 6.588509
136R:R:I695 1.945404
137R:R:V741 2.025404
138R:R:F743 4.295408
139R:R:L752 3.868528
140R:R:P753 7.2875429
141R:R:Y756 5.93714729
142R:R:F761 6.5225405
143R:R:Y769 9.27754228
144R:R:I790 2.9225408
145R:R:Y807 10.506508
146R:R:F808 7.641676209
147R:R:Y818 4.52406
148R:R:F827 8.858527
149R:R:N828 9.0825426
150R:R:M830 5.0175404
151R:R:Q832 4.632528
152R:R:Y834 7.87167626
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:S74 11.36534.42YesNo099
2B:B:H54 B:B:S74 11.16513.95YesNo099
3A:A:Y37 B:B:D76 16.04123.45YesYes149
4A:A:R42 A:A:Y37 18.894911.32NoYes194
5A:A:F222 A:A:R42 19.02113.21YesNo179
6A:A:F222 A:A:F238 17.19796.43YesYes179
7A:A:F238 A:A:W234 22.58634.01YesYes199
8A:A:R231 A:A:W234 78.25169NoYes099
9A:A:D272 A:A:R231 77.981311.91NoNo089
10A:A:D272 A:A:F246 77.86175.97NoNo089
11A:A:F246 A:A:F345 76.67313.22NoYes798
12A:A:F345 A:A:L270 95.828210.96YesNo086
13A:A:E344 A:A:L270 95.78083.98NoNo056
14A:A:E344 A:A:F340 95.75997NoYes057
15A:A:F315 A:A:F340 95.288918.22YesYes467
16A:A:F315 A:A:I308 10010.05YesNo067
17A:A:I308 A:A:Y253 99.977110.88NoYes078
18A:A:Y253 A:A:Y311 99.8833.97YesNo086
19A:A:N254 A:A:Y311 99.83436.98NoNo096
20A:A:D252 A:A:N254 99.80965.39YesNo089
21A:A:D249 A:A:D252 99.55146.65YesYes1188
22A:A:D249 A:A:K293 99.622111.06YesNo089
23A:A:K293 A:A:N292 99.6115.6NoYes099
24A:A:N292 A:A:V247 99.5224.43YesNo097
25A:A:S51 A:A:V247 99.49186.46YesNo097
26A:A:K53 A:A:S51 99.36836.12NoYes099
27A:A:K53 A:A:L45 99.27282.82NoNo098
28A:A:I245 A:A:L45 99.24054.28NoNo078
29A:A:I245 A:A:L43 99.17494.28NoNo077
30A:A:F219 A:A:L43 96.96133.65YesNo087
31A:A:F219 A:A:H41 40.24525.66YesYes886
32A:A:H41 A:A:I383 40.06815.3YesNo068
33B:B:W332 B:B:Y59 22.93115.79YesYes198
34A:A:C237 B:B:Y59 20.85574.03NoYes188
35A:A:C237 B:B:L117 21.40363.17NoYes189
36A:A:Q227 B:B:L117 21.6786.65YesYes199
37A:A:F219 A:A:F376 57.21374.29YesNo088
38B:B:C148 B:B:T102 13.89743.38NoNo068
39B:B:C149 B:B:T102 14.01075.07NoNo088
40B:B:C149 B:B:T159 12.7043.38NoYes089
41B:B:H142 B:B:T159 12.85385.48YesYes199
42B:B:H142 B:B:S161 23.410215.34YesNo199
43B:B:G162 B:B:S161 25.66213.71NoNo199
44B:B:G162 B:B:Y145 24.31210.14NoYes198
45A:A:W234 B:B:Y145 68.13655.79YesYes198
46A:A:K233 B:B:Y145 68.65463.58YesYes198
47A:A:K233 B:B:D228 33.80888.3YesYes199
48A:A:K233 B:B:D246 33.81074.15YesYes199
49A:A:W281 B:B:W332 15.01363.75YesYes159
50B:B:R314 B:B:W332 15.298417.99YesYes189
51A:A:T380 R:R:T835 57.05133.14NoNo067
52A:A:F376 A:A:T380 57.13256.49NoNo086
53A:A:R280 A:A:W281 23.754415.99NoYes055
54A:A:R280 A:A:R283 23.74197.46NoNo053
55A:A:R283 A:A:R356 23.73058.53NoNo032
56A:A:H357 A:A:R356 23.85977.9NoNo072
57A:A:H357 A:A:W277 23.939828.56NoYes776
58A:A:F273 A:A:W277 23.68475.01YesYes796
59A:A:W281 B:B:D290 23.21318.93YesYes156
60B:B:D290 B:B:R314 12.10888.34YesYes168
61A:A:I383 A:A:N387 39.96474.25NoNo087
62R:R:T835 R:R:Y834 49.57663.75NoYes076
63R:R:F659 R:R:Y834 44.30966.19YesYes296
64A:A:N387 R:R:Y669 39.77844.65NoNo077
65R:R:F659 R:R:Y756 44.39519.28YesYes299
66A:A:C391 R:R:Y669 39.62444.03NoNo057
67A:A:C391 A:A:L393 39.54733.17NoNo058
68A:A:L393 R:R:I655 39.47024.28NoNo089
69R:R:I655 R:R:Y756 44.63486.04NoYes099
70B:B:C148 B:B:L190 12.75983.17NoYes065
71B:B:D258 B:B:R22 35.31717.15YesYes176
72B:B:I18 B:B:R22 30.66476.26NoYes076
73B:B:I18 G:G:A23 29.48873.25NoNo078
74B:B:Q17 G:G:A23 28.31241.52NoNo048
75B:B:L14 B:B:Q17 27.13592.66NoNo084
76B:B:L14 G:G:L19 24.78195.54NoNo089
77B:B:A11 G:G:L19 17.71361.58NoNo059
78B:B:A11 G:G:V16 16.53461.7NoNo057
79B:B:L7 G:G:V16 14.17572.98YesNo087
80B:B:D258 B:B:F222 48.87274.78YesYes178
81B:B:D258 G:G:R27 12.94979.53YesYes178
82B:B:C25 G:G:R27 10.75664.18NoYes038
83B:B:C271 B:B:D290 34.67083.11NoYes156
84B:B:C271 B:B:Y289 32.64444.03NoYes157
85B:B:W297 B:B:Y289 26.96145.79YesYes187
86B:B:W297 B:B:Y264 26.026.75YesYes085
87B:B:D228 B:B:S227 35.34044.42YesNo196
88B:B:S227 B:B:S245 68.61223.26NoNo169
89B:B:H225 B:B:S245 46.004211.16YesNo199
90B:B:D246 B:B:S227 33.66114.42YesNo196
91B:B:H225 B:B:T243 24.23458.21YesNo098
92B:B:D247 B:B:S245 22.24117.36YesNo199
93B:B:F253 B:B:R251 38.38284.28YesYes168
94B:B:L252 B:B:Y264 12.38497.03NoYes075
95B:B:F278 B:B:L252 10.6863.65YesNo077
96B:B:L285 B:B:Y264 11.35294.69NoYes065
97B:B:F278 B:B:L285 10.67349.74YesNo076
98B:B:F235 B:B:F278 10.3410.72YesYes967
99B:B:R314 B:B:T274 12.38836.47YesNo088
100B:B:S275 B:B:T274 12.16363.2NoNo088
101B:B:C294 B:B:L318 11.75043.17NoNo056
102R:R:I655 R:R:R651 83.62653.76NoNo099
103R:R:E758 R:R:R651 37.42196.98NoNo099
104R:R:E758 R:R:F761 37.14494.66NoYes095
105R:R:F761 R:R:I803 68.98993.77YesNo058
106R:R:I803 R:R:N799 68.14932.83NoNo089
107R:R:N799 R:R:Y769 67.56699.3NoYes098
108R:R:F641 R:R:Y769 61.114411.35YesYes2288
109R:R:F641 R:R:T796 27.92425.19YesNo088
110R:R:L793 R:R:T796 27.32334.42NoNo088
111R:R:L793 R:R:Y621 21.28199.38NoNo088
112R:R:R633 R:R:Y621 18.276719.55NoNo088
113R:R:D792 R:R:R633 17.67143.57NoNo098
114R:R:D792 R:R:L776 17.06596.79NoNo099
115R:R:L776 R:R:M780 12.81945.65NoNo098
116R:R:M780 R:R:V788 11.60364.56NoNo087
117R:R:V788 R:R:Y783 10.99536.31NoNo078
118R:R:S784 R:R:Y783 10.38686.36NoNo068
119R:R:R651 R:R:Y807 45.95957.2NoYes098
120R:R:F761 R:R:Y807 37.640312.38YesYes058
121R:R:F641 R:R:L800 33.32046.09YesNo088
122R:R:L800 R:R:Y615 10.38687.03NoYes088
123R:R:C640 R:R:L800 22.50613.17YesNo078
124R:R:C640 R:R:L610 20.69513.17YesNo078
125R:R:I643 R:R:L610 20.09094.28YesNo078
126R:R:I643 R:R:T642 17.67143.04YesNo078
127R:R:K689 R:R:T642 15.247618.02YesNo098
128R:R:K689 R:R:V693 10.38684.55YesNo097
129A:A:F273 A:A:F345 23.52996.43YesYes798
130B:B:L318 B:B:S275 11.94924.5NoNo068
131B:B:H225 B:B:R251 20.304916.93YesYes198
132B:B:D247 B:B:R251 20.28693.57YesYes198
133B:B:F253 B:B:T243 19.15167.78YesNo068
134B:B:F222 B:B:F253 52.87711.79YesYes186
135A:A:Q227 B:B:Y145 21.11887.89YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9NOX
Class C
SubFamily Sensory
Type Taste1
SubType TAS1R2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGt3)/Beta1/Gamma2
PDB Resolution 3
Date 2025-04-09
D.O.I. doi.org/10.1016/j.cell.2025.04.021
Net Summary
Imin 3.07
Number of Linked Nodes 837
Number of Links 1004
Number of Hubs 152
Number of Links mediated by Hubs 573
Number of Communities 23
Number of Nodes involved in Communities 212
Number of Links involved in Communities 314
Path Summary
Number Of Nodes in MetaPath 136
Number Of Links MetaPath 135
Number of Shortest Paths 1335010
Length Of Smallest Path 3
Average Path Length 37.0592
Length of Longest Path 80
Minimum Path Strength 1.225
Average Path Strength 6.51426
Maximum Path Strength 18.86
Minimum Path Correlation 0.7
Average Path Correlation 0.98469
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 44.6985
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3386
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• sensory perception of sweet taste   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • response to stimulus   • detection of chemical stimulus involved in sensory perception of sweet taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • response to chemical   • detection of chemical stimulus   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • protein-containing complex   • receptor complex   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • taste receptor complex   • sweet taste receptor complex   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled receptor activity   • sensory perception of umami taste   • Golgi apparatus   • endomembrane system
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9NOX_Chain_A
EDQRNEEKA QREANKKIE KQLQKDKQV YRATHRLLL LGASGKSTI 
VKQMRILHS GIFETKFQV DKVNFHMFD VGGQRDERR KWIQCFNDV 
TAIIFVVSS YNRLQEALN FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT RAKYFIRDE 
FLRISTASG DGRHYCYPH FTCAVDTNV FDIILLDNG GSDDDQVKF 
DAVTIKENK DCGF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9NOX_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9NOX_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASEN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TE23
Sequence
>9NOX_Chain_R
LEWHEAPTI AVALLAALG FLSTLAILV IFWRHFQTP IVRSAGGPM 
CFLMLTLLL VAYMVVPVY VGPPKVSTC LCRQALFPL CFTICISCI 
AVRSFQIVC AFKMASRFP RAYSYWVRY QGPYVSMAF ITVLKMVIV 
VIGMLAYRN SLLFNTSLD LLLSVVGFS FAYMGKELP TNYNEAKFI 
TLSMTFYFT SSVSLCTFM SAYSGVLVT IVDLLVTVL NLLAISLGY 
FGPKCYMIL FYPERNTPA YFNSMIQGY TMRRD


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9NOXCSensoryTaste1TAS1R2Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOX (No Gprot) CSensoryTaste1TAS1R2Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOYCSensoryTaste1TAS1R2Homo sapiens---3.72025-04-09doi.org/10.1016/j.cell.2025.04.021
9NORCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.42025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOSCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.52025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOTCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.82025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38 (No Gprot) CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9OQ0CSensoryTaste1TAS1R2; TAS1R3Homo sapiens; mus musculus---3.672025-08-27To be published
9UT8CSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.412025-07-16doi.org/10.1038/s41586-025-09302-6
9UTACSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.772025-07-16doi.org/10.1038/s41586-025-09302-6
9UTBCSensoryTaste1TAS1R2; TAS1R3Homo sapiensSucralose--3.592025-07-16doi.org/10.1038/s41586-025-09302-6




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