psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L559	R:R:V622	8.94	No	No	0	8	7
2	R:R:L559	R:R:T789	5.9	No	No	5	8	7
3	R:R:I790	R:R:L559	8.56	Yes	No	5	8	8
4	R:R:V622	R:R:W561	9.81	No	No	0	7	5
5	R:R:E563	R:R:P565	15.72	No	No	0	8	6
6	R:R:E563	R:R:T566	8.47	No	No	0	8	7
7	R:R:L793	R:R:V569	7.45	No	No	6	8	8
8	R:R:V569	R:R:V797	4.81	No	No	6	8	9
9	R:R:L572	R:R:L798	2.77	No	No	0	3	7
10	R:R:L572	R:R:L801	6.92	No	No	0	3	6
11	R:R:A573	R:R:V618	5.09	No	Yes	0	7	7
12	R:R:G576	R:R:Y615	5.79	No	Yes	0	6	8
13	R:R:F577	R:R:L612	7.31	Yes	No	0	6	4
14	R:R:F577	R:R:Y615	3.09	Yes	Yes	0	6	8
15	R:R:F577	R:R:M616	3.73	Yes	No	0	6	6
16	R:R:L805	R:R:S579	3	No	No	0	2	4
17	R:R:L612	R:R:T580	2.95	No	No	0	4	8
18	R:R:T580	R:R:Y615	6.24	No	Yes	0	8	8
19	R:R:I583	R:R:L608	4.28	No	No	3	7	9
20	R:R:F808	R:R:I583	5.02	Yes	No	3	9	7
21	R:R:C812	R:R:I583	8.18	No	No	0	7	7
22	R:R:F605	R:R:L584	3.65	No	No	0	6	4
23	R:R:L584	R:R:L608	4.15	No	No	0	4	9
24	R:R:C812	R:R:I586	4.91	No	No	0	7	5
25	R:R:I586	R:R:I815	2.94	No	Yes	1	5	8
26	R:R:I586	R:R:L816	7.14	No	Yes	1	5	6
27	R:R:C604	R:R:F587	4.19	No	No	3	9	9
28	R:R:F587	R:R:F808	4.29	No	Yes	3	9	9
29	R:R:C812	R:R:F587	4.19	No	No	0	7	9
30	R:R:H590	R:R:L816	3.86	No	Yes	0	5	6
31	R:R:F591	R:R:V596	7.87	No	No	0	5	9
32	R:R:F591	R:R:F605	9.65	No	No	0	5	6
33	R:R:P594	R:R:T593	3.5	Yes	Yes	1	8	9
34	R:R:I595	R:R:T593	3.04	Yes	Yes	1	7	9
35	R:R:T593	R:R:V596	4.76	Yes	No	0	9	9
36	R:R:N822	R:R:T593	10.24	Yes	Yes	1	9	9
37	R:R:N822	R:R:P594	6.52	Yes	Yes	1	9	8
38	R:R:P594	R:R:P824	9.74	Yes	No	0	8	6
39	R:R:F827	R:R:P594	13	Yes	Yes	1	7	8
40	R:R:I595	R:R:N755	2.83	Yes	Yes	1	7	8
41	R:R:I595	R:R:K811	7.27	Yes	No	0	7	9
42	R:R:I595	R:R:I815	8.83	Yes	Yes	1	7	8
43	R:R:I595	R:R:N822	8.5	Yes	Yes	1	7	9
44	R:R:S598	R:R:Y756	6.36	No	Yes	1	9	9
45	R:R:F827	R:R:S598	5.28	Yes	No	1	7	9
46	R:R:A599	R:R:K811	3.21	No	No	0	9	9
47	R:R:G601	R:R:P602	4.06	No	No	0	8	6
48	R:R:C647	R:R:M603	6.48	Yes	No	0	7	8
49	R:R:C604	R:R:F808	5.59	No	Yes	3	9	9
50	R:R:C644	R:R:M607	3.24	No	Yes	0	7	8
51	R:R:C647	R:R:M607	3.24	Yes	Yes	0	7	8
52	R:R:I648	R:R:M607	4.37	No	Yes	0	7	8
53	R:R:F808	R:R:M607	4.98	Yes	Yes	0	9	8
54	R:R:F808	R:R:L608	17.05	Yes	No	3	9	9
55	R:R:C640	R:R:L610	6.35	Yes	No	0	7	8
56	R:R:I643	R:R:L610	4.28	Yes	No	0	7	8
57	R:R:C640	R:R:L611	3.17	Yes	No	0	7	9
58	R:R:L636	R:R:V613	4.47	No	No	0	6	6
59	R:R:A614	R:R:F637	2.77	No	Yes	0	6	8
60	R:R:A614	R:R:C640	3.61	No	Yes	0	6	7
61	R:R:L800	R:R:Y615	7.03	No	Yes	0	8	8
62	R:R:S804	R:R:Y615	3.82	No	Yes	0	8	8
63	R:R:L636	R:R:V617	4.47	No	Yes	0	6	6
64	R:R:P619	R:R:V618	3.53	No	Yes	0	6	7
65	R:R:F637	R:R:V618	3.93	Yes	Yes	0	8	7
66	R:R:V618	R:R:V797	3.21	Yes	No	0	7	9
67	R:R:R633	R:R:Y621	17.49	No	No	0	8	8
68	R:R:F637	R:R:Y621	10.32	Yes	No	0	8	8
69	R:R:L793	R:R:Y621	5.86	No	No	0	8	8
70	R:R:G623	R:R:P624	4.06	No	No	0	8	5
71	R:R:K626	R:R:S628	4.59	No	No	0	5	4
72	R:R:K626	R:R:T629	3	No	No	0	5	6
73	R:R:Q634	R:R:R633	5.84	No	No	0	8	8
74	R:R:R633	R:R:Y724	12.35	No	Yes	0	8	8
75	R:R:K689	R:R:P638	3.35	No	No	0	9	5
76	R:R:I643	R:R:L639	4.28	Yes	No	0	7	7
77	R:R:C640	R:R:L800	3.17	Yes	No	0	7	8
78	R:R:D735	R:R:F641	3.58	No	Yes	2	8	8
79	R:R:F641	R:R:Y769	10.32	Yes	Yes	2	8	8
80	R:R:F641	R:R:T796	5.19	Yes	No	0	8	8
81	R:R:F641	R:R:L800	7.31	Yes	No	0	8	8
82	R:R:K689	R:R:T642	12.01	No	No	0	9	8
83	R:R:I643	R:R:S646	3.1	Yes	No	7	7	9
84	R:R:I643	R:R:M682	2.92	Yes	No	7	7	7
85	R:R:I643	R:R:T686	4.56	Yes	No	0	7	7
86	R:R:C644	R:R:I803	9.82	No	No	0	7	8
87	R:R:D735	R:R:I645	5.6	No	No	0	8	7
88	R:R:I645	R:R:L738	2.85	No	Yes	0	7	9
89	R:R:I645	R:R:I803	2.94	No	No	0	7	8
90	R:R:M682	R:R:S646	3.07	No	No	7	7	9
91	R:R:I685	R:R:S646	6.19	No	No	0	5	9
92	R:R:C647	R:R:M682	3.24	Yes	No	0	7	7
93	R:R:I648	R:R:Y807	8.46	No	Yes	0	7	8
94	R:R:E758	R:R:R651	6.98	No	No	0	9	9
95	R:R:R651	R:R:Y807	10.29	No	Yes	0	9	8
96	R:R:A746	R:R:S652	3.42	No	No	0	9	9
97	R:R:C657	R:R:F653	6.98	No	No	0	6	7
98	R:R:F653	R:R:W672	18.04	No	Yes	0	7	6
99	R:R:F653	R:R:F745	9.65	No	No	0	7	7
100	R:R:Q654	R:R:W672	3.29	No	Yes	4	8	6
101	R:R:P678	R:R:Q654	12.63	Yes	No	4	8	8
102	R:R:I655	R:R:Y756	7.25	No	Yes	0	9	9
103	R:R:C657	R:R:Y669	6.72	No	No	0	6	7
104	R:R:F659	R:R:L752	6.09	Yes	Yes	1	9	8
105	R:R:F659	R:R:P753	5.78	Yes	Yes	1	9	9
106	R:R:F659	R:R:Y756	7.22	Yes	Yes	1	9	9
107	R:R:F659	R:R:I831	3.77	Yes	No	1	9	7
108	R:R:F659	R:R:Y834	6.19	Yes	Yes	1	9	6
109	R:R:K660	R:R:M661	2.88	No	No	0	6	7
110	R:R:E751	R:R:K660	4.05	No	No	0	7	6
111	R:R:M661	R:R:R664	6.2	No	No	0	7	7
112	R:R:F665	R:R:R664	3.21	No	No	0	5	7
113	R:R:A668	R:R:R667	4.15	No	No	0	5	5
114	R:R:R667	R:R:Y671	3.09	No	No	0	5	5
115	R:R:W672	R:R:Y669	5.79	Yes	No	0	6	7
116	R:R:S670	R:R:Y671	3.82	No	No	0	4	5
117	R:R:G677	R:R:W672	8.44	No	Yes	4	8	6
118	R:R:P678	R:R:W672	12.16	Yes	Yes	4	8	6
119	R:R:S681	R:R:W672	6.18	No	Yes	0	7	6
120	R:R:R674	R:R:Y675	13.38	No	No	0	7	6
121	R:R:G677	R:R:P678	4.06	No	Yes	4	8	8
122	R:R:F684	R:R:L688	4.87	No	No	0	3	6
123	R:R:I685	R:R:L738	7.14	No	Yes	0	5	9
124	R:R:L688	R:R:L734	2.77	No	No	0	6	8
125	R:R:K689	R:R:V693	3.04	No	No	0	9	7
126	R:R:M690	R:R:V691	3.04	No	No	0	4	3
127	R:R:L728	R:R:Y724	3.52	No	Yes	0	7	8
128	R:R:M780	R:R:Y724	8.38	No	Yes	0	8	8
129	R:R:D792	R:R:Y724	8.05	No	Yes	0	9	8
130	R:R:R725	R:R:S781	6.59	No	No	0	2	5
131	R:R:L728	R:R:S727	3	No	No	0	7	6
132	R:R:L728	R:R:N731	4.12	No	No	0	7	7
133	R:R:S773	R:R:T732	6.4	No	No	0	9	7
134	R:R:L734	R:R:L738	2.77	No	Yes	0	8	9
135	R:R:D735	R:R:Y769	14.94	No	Yes	2	8	8
136	R:R:L737	R:R:L738	2.77	No	Yes	0	4	9
137	R:R:M766	R:R:S739	4.6	No	No	0	9	8
138	R:R:G742	R:R:V741	3.68	No	No	0	9	4
139	R:R:F743	R:R:T763	3.89	Yes	No	0	8	9
140	R:R:M748	R:R:Y747	5.99	No	No	0	7	8
141	R:R:K750	R:R:Y747	10.75	No	No	0	9	8
142	R:R:G749	R:R:L752	3.42	No	Yes	0	9	8
143	R:R:E751	R:R:Y834	11.22	No	Yes	0	7	6
144	R:R:L752	R:R:P753	3.28	Yes	Yes	1	8	9
145	R:R:L752	R:R:Y834	3.52	Yes	Yes	1	8	6
146	R:R:P753	R:R:Y756	2.78	Yes	Yes	1	9	9
147	R:R:M830	R:R:P753	6.71	No	Yes	1	4	9
148	R:R:P753	R:R:Y834	11.13	Yes	Yes	1	9	6
149	R:R:N755	R:R:T754	4.39	Yes	No	0	8	7
150	R:R:F827	R:R:N755	7.25	Yes	Yes	1	7	8
151	R:R:M830	R:R:N755	5.61	No	Yes	1	4	8
152	R:R:F827	R:R:Y756	7.22	Yes	Yes	1	7	9
153	R:R:I831	R:R:Y756	4.84	No	Yes	1	7	9
154	R:R:A759	R:R:N757	3.13	No	No	0	9	9
155	R:R:K760	R:R:L764	2.82	No	No	0	9	9
156	R:R:F761	R:R:I762	3.77	Yes	No	0	5	9
157	R:R:F761	R:R:S765	9.25	Yes	No	0	5	9
158	R:R:F761	R:R:G806	3.01	Yes	No	0	5	6
159	R:R:F761	R:R:Y807	9.28	Yes	Yes	0	5	8
160	R:R:F768	R:R:S772	5.28	Yes	No	2	7	9
161	R:R:F768	R:R:L798	3.65	Yes	No	0	7	7
162	R:R:F768	R:R:N799	3.62	Yes	No	2	7	9
163	R:R:A802	R:R:F768	2.77	No	Yes	0	7	7
164	R:R:S773	R:R:Y769	5.09	No	Yes	0	9	8
165	R:R:N799	R:R:Y769	9.3	No	Yes	2	9	8
166	R:R:F770	R:R:V774	3.93	No	No	0	6	6
167	R:R:S772	R:R:V795	3.23	No	No	0	9	8
168	R:R:N799	R:R:S772	2.98	No	No	2	9	9
169	R:R:L776	R:R:M780	4.24	No	No	0	9	8
170	R:R:D792	R:R:L776	5.43	No	No	0	9	9
171	R:R:L776	R:R:V795	4.47	No	No	0	9	8
172	R:R:M780	R:R:V788	3.04	No	No	0	8	7
173	R:R:S784	R:R:Y783	11.45	No	No	0	6	8
174	R:R:V788	R:R:Y783	6.31	No	No	0	7	8
175	R:R:L787	R:R:V786	4.47	No	No	0	5	8
176	R:R:I790	R:R:L787	4.28	Yes	No	0	8	5
177	R:R:I790	R:R:T789	3.04	Yes	No	5	8	7
178	R:R:L793	R:R:V797	2.98	No	No	6	8	9
179	R:R:L794	R:R:L798	2.77	No	No	0	7	7
180	R:R:L805	R:R:S804	4.5	No	No	0	2	8
181	R:R:F808	R:R:Y807	10.32	Yes	Yes	0	9	8
182	R:R:K811	R:R:Y807	11.94	No	Yes	0	9	8
183	R:R:G809	R:R:P810	4.06	No	No	0	3	9
184	R:R:F817	R:R:Y813	7.22	No	No	0	5	8
185	R:R:I815	R:R:L816	2.85	Yes	Yes	1	8	6
186	R:R:I815	R:R:N822	4.25	Yes	Yes	1	8	9
187	R:R:R821	R:R:Y818	11.32	No	No	0	5	6
188	R:R:R821	R:R:Y826	9.26	No	No	0	5	5
189	R:R:P824	R:R:T823	3.5	No	No	0	6	7
190	R:R:F827	R:R:M830	7.46	Yes	No	1	7	4
191	R:R:T835	R:R:Y834	3.75	No	Yes	0	7	6
192	R:R:R837	R:R:Y834	7.2	No	Yes	0	7	6
193	R:R:M836	R:R:R838	4.96	No	No	0	7	4
194	R:R:D839	R:R:R837	3.57	No	No	0	5	7
195	R:R:F637	R:R:V617	2.62	Yes	Yes	0	8	6
196	R:R:F779	R:R:T778	2.59	No	No	0	7	8
197	R:R:F743	R:R:M766	2.49	Yes	No	0	8	9
198	R:R:M814	R:R:R821	2.48	No	No	0	8	5
199	R:R:L787	R:R:Y783	2.34	No	No	0	5	8
200	R:R:H590	R:R:R589	2.26	No	No	0	5	4
201	R:R:G600	R:R:G601	2.11	No	No	0	9	8
202	R:R:R674	R:R:Y671	2.06	No	No	0	7	5
203	R:R:F743	R:R:Y747	2.06	Yes	No	0	8	8
204	R:R:F605	R:R:W588	2	No	No	0	6	5
205	R:R:C604	R:R:G600	1.96	No	No	0	9	9
206	R:R:P624	R:R:P625	1.95	No	No	0	5	9
207	R:R:A649	R:R:G742	1.95	No	No	0	8	9
208	R:R:A564	R:R:P565	1.87	No	No	0	4	6
209	R:R:G785	R:R:S784	1.86	No	No	0	7	6
210	R:R:G623	R:R:V622	1.84	No	No	0	8	7
211	R:R:G677	R:R:V680	1.84	No	No	0	8	4
212	R:R:G696	R:R:I695	1.76	No	No	0	7	4
213	R:R:G576	R:R:L575	1.71	No	No	0	6	2
214	R:R:C632	R:R:V617	1.71	No	Yes	0	6	6
215	R:R:A782	R:R:S781	1.71	No	No	0	8	5
216	R:R:I790	R:R:P565	1.69	Yes	No	0	8	6
217	R:R:A825	R:R:T823	1.68	No	No	0	6	7
218	R:R:G833	R:R:Q832	1.64	No	No	0	4	8
219	R:R:S681	R:R:V650	1.62	No	No	0	7	8
220	R:R:S652	R:R:V656	1.62	No	No	0	9	7
221	R:R:V617	R:R:V620	1.6	Yes	No	0	6	6
222	R:R:C647	R:R:L606	1.59	Yes	No	0	7	6
223	R:R:T629	R:R:V620	1.59	No	No	0	6	6
224	R:R:C777	R:R:L729	1.59	No	No	0	7	5
225	R:R:T778	R:R:V774	1.59	No	No	0	8	6
226	R:R:A635	R:R:L631	1.58	No	No	0	5	5
227	R:R:P638	R:R:Q634	1.58	No	No	0	5	8
228	R:R:C630	R:R:Q634	1.53	No	No	0	9	8
229	R:R:I567	R:R:T566	1.52	No	No	0	6	7
230	R:R:M603	R:R:V650	1.52	No	No	0	8	8
231	R:R:M766	R:R:V740	1.52	No	No	0	9	2
232	R:R:L581	R:R:V585	1.49	No	No	0	3	1
233	R:R:L752	R:R:V656	1.49	Yes	No	0	8	7
234	R:R:L584	R:R:T609	1.47	No	No	0	4	4
235	R:R:I692	R:R:I695	1.47	No	No	0	6	4
236	R:R:L729	R:R:T732	1.47	No	No	0	5	7
237	R:R:I815	R:R:M814	1.46	Yes	No	0	8	8
238	R:R:F665	R:R:P666	1.44	No	No	0	5	7
239	R:R:I695	R:R:L698	1.43	No	No	0	4	3
240	R:R:I692	R:R:N731	1.42	No	No	0	6	7
241	R:R:P602	R:R:Y679	1.39	No	No	0	6	5
242	R:R:A668	R:R:F665	1.39	No	No	0	5	5
243	R:R:P678	R:R:Y679	1.39	Yes	No	0	8	5
244	R:R:P819	R:R:Y818	1.39	No	No	0	8	6
245	R:R:L581	R:R:L612	1.38	No	No	0	3	4
246	R:R:L752	R:R:N757	1.37	Yes	No	0	8	9
247	R:R:M836	R:R:Q832	1.36	No	No	0	7	8
248	R:R:F745	R:R:S744	1.32	No	No	0	7	4
249	R:R:R597	R:R:V596	1.31	No	No	0	7	9
250	R:R:F768	R:R:T771	1.3	Yes	No	0	7	8
251	R:R:F770	R:R:T771	1.3	No	No	0	6	8
252	R:R:E560	R:R:E563	1.27	No	No	0	6	8
253	R:R:S829	R:R:Y826	1.27	No	No	0	5	5
254	R:R:F743	R:R:I762	1.26	Yes	No	0	8	9
255	R:R:F577	R:R:L578	1.22	Yes	No	0	6	3
256	R:R:F770	R:R:L736	1.22	No	No	0	6	6
257	R:R:F817	R:R:L816	1.22	No	Yes	0	5	6
258	R:R:D839	R:R:R838	1.19	No	No	0	5	4
259	R:R:F591	R:R:Q592	1.17	No	No	0	5	4
260	R:R:Q676	R:R:Y679	1.13	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F577	3.8375	4	0	6
2	R:R:T593	5.385	4	1	9
3	R:R:P594	8.19	4	1	8
4	R:R:I595	6.094	5	1	7
5	R:R:M607	3.9575	4	0	8
6	R:R:Y615	5.194	5	0	8
7	R:R:V617	2.6	4	0	6
8	R:R:V618	3.94	4	0	7
9	R:R:F637	4.91	4	0	8
10	R:R:C640	4.075	4	0	7
11	R:R:F641	6.6	4	2	8
12	R:R:I643	3.828	5	7	7
13	R:R:C647	3.6375	4	0	7
14	R:R:F659	5.81	5	1	9
15	R:R:W672	8.98333	6	4	6
16	R:R:P678	7.56	4	4	8
17	R:R:Y724	8.075	4	0	8
18	R:R:L738	3.8825	4	0	9
19	R:R:F743	2.425	4	0	8
20	R:R:L752	3.195	6	1	8
21	R:R:P753	5.936	5	1	9
22	R:R:N755	5.02	4	1	8
23	R:R:Y756	5.945	6	1	9
24	R:R:F761	6.3275	4	0	5
25	R:R:F768	3.324	5	2	7
26	R:R:Y769	9.9125	4	2	8
27	R:R:I790	4.3925	4	5	8
28	R:R:Y807	10.058	5	0	8
29	R:R:F808	7.875	6	3	9
30	R:R:I815	4.066	5	1	8
31	R:R:L816	3.7675	4	1	6
32	R:R:N822	7.3775	4	1	9
33	R:R:F827	8.042	5	1	7
34	R:R:Y834	7.16833	6	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I790	R:R:P565	10.7057	1.69	Yes	No	0	8	6
2	R:R:I790	R:R:L559	10.6742	8.56	Yes	No	5	8	8
3	R:R:I790	R:R:L787	24.3988	4.28	Yes	No	0	8	5
4	R:R:L787	R:R:Y783	27.7119	2.34	No	No	0	5	8
5	R:R:V788	R:R:Y783	32.6053	6.31	No	No	0	7	8
6	R:R:M780	R:R:V788	34.0439	3.04	No	No	0	8	7
7	R:R:M780	R:R:Y724	10.9472	8.38	No	Yes	0	8	8
8	R:R:R633	R:R:Y724	21.2066	12.35	No	Yes	0	8	8
9	R:R:R633	R:R:Y621	28.6727	17.49	No	No	0	8	8
10	R:R:L776	R:R:M780	29.9695	4.24	No	No	0	9	8
11	R:R:L776	R:R:V795	34.7422	4.47	No	No	0	9	8
12	R:R:S772	R:R:V795	35.7608	3.23	No	No	0	9	8
13	R:R:F637	R:R:Y621	31.2454	10.32	Yes	No	0	8	8
14	R:R:L800	R:R:Y615	44.5185	7.03	No	Yes	0	8	8
15	R:R:C640	R:R:L800	29.182	3.17	Yes	No	0	7	8
16	R:R:A614	R:R:C640	49.4592	3.61	No	Yes	0	6	7
17	R:R:A614	R:R:F637	48.3094	2.77	No	Yes	0	6	8
18	R:R:F641	R:R:L800	26.772	7.31	Yes	No	0	8	8
19	R:R:N799	R:R:Y769	50.9031	9.3	No	Yes	2	9	8
20	R:R:N799	R:R:S772	32.8363	2.98	No	No	2	9	9
21	R:R:F577	R:R:Y615	16.8959	3.09	Yes	Yes	0	6	8
22	R:R:T580	R:R:Y615	11.2675	6.24	No	Yes	0	8	8
23	R:R:F808	R:R:I583	11.908	5.02	Yes	No	3	9	7
24	R:R:F808	R:R:M607	90.2237	4.98	Yes	Yes	0	9	8
25	R:R:C644	R:R:M607	75.7377	3.24	No	Yes	0	7	8
26	R:R:C644	R:R:I803	75.0394	9.82	No	No	0	7	8
27	R:R:I645	R:R:I803	74.5091	2.94	No	No	0	7	8
28	R:R:D735	R:R:I645	72.0204	5.6	No	No	0	8	7
29	R:R:D735	R:R:Y769	49.4645	14.94	No	Yes	2	8	8
30	R:R:C812	R:R:I583	11.4512	8.18	No	No	0	7	7
31	R:R:C812	R:R:F587	12.6536	4.19	No	No	0	7	9
32	R:R:F587	R:R:F808	11.761	4.29	No	Yes	3	9	9
33	R:R:C812	R:R:I586	22.6242	4.91	No	No	0	7	5
34	R:R:I586	R:R:I815	12.9634	2.94	No	Yes	1	5	8
35	R:R:I595	R:R:I815	15.5098	8.83	Yes	Yes	1	7	8
36	R:R:I595	R:R:K811	97.5113	7.27	Yes	No	0	7	9
37	R:R:K811	R:R:Y807	100	11.94	No	Yes	0	9	8
38	R:R:F808	R:R:Y807	62.7533	10.32	Yes	Yes	0	9	8
39	R:R:I648	R:R:Y807	57.1511	8.46	No	Yes	0	7	8
40	R:R:I648	R:R:M607	57.4871	4.37	No	Yes	0	7	8
41	R:R:I595	R:R:T593	14.0607	3.04	Yes	Yes	1	7	9
42	R:R:P594	R:R:T593	11.1677	3.5	Yes	Yes	1	8	9
43	R:R:P594	R:R:P824	12.2335	9.74	Yes	No	0	8	6
44	R:R:F827	R:R:N755	10.4379	7.25	Yes	Yes	1	7	8
45	R:R:I595	R:R:N755	68.4343	2.83	Yes	Yes	1	7	8
46	R:R:F827	R:R:Y756	11.6717	7.22	Yes	Yes	1	7	9
47	R:R:C647	R:R:M682	68.0353	3.24	Yes	No	0	7	7
48	R:R:I643	R:R:M682	64.717	2.92	Yes	No	7	7	7
49	R:R:I643	R:R:L610	64.318	4.28	Yes	No	0	7	8
50	R:R:C640	R:R:L610	63.6512	6.35	Yes	No	0	7	8
51	R:R:C647	R:R:M603	21.3326	6.48	Yes	No	0	7	8
52	R:R:F637	R:R:V617	13.5777	2.62	Yes	Yes	0	8	6
53	R:R:Q634	R:R:R633	10.9787	5.84	No	No	0	8	8
54	R:R:L752	R:R:P753	14.1132	3.28	Yes	Yes	1	8	9
55	R:R:M830	R:R:P753	55.5655	6.71	No	Yes	1	4	9
56	R:R:M830	R:R:N755	54.8987	5.61	No	Yes	1	4	8
57	R:R:S681	R:R:W672	16.7699	6.18	No	Yes	0	7	6
58	R:R:S681	R:R:V650	18.2348	1.62	No	No	0	7	8
59	R:R:M603	R:R:V650	19.8099	1.52	No	No	0	8	8
60	R:R:P753	R:R:Y834	40.4494	11.13	Yes	Yes	1	9	6
61	R:R:E751	R:R:K660	24.3463	4.05	No	No	0	7	6
62	R:R:E751	R:R:Y834	26.478	11.22	No	Yes	0	7	6
63	R:R:K660	R:R:M661	22.4142	2.88	No	No	0	6	7
64	R:R:M661	R:R:R664	20.2195	6.2	No	No	0	7	7
65	R:R:F665	R:R:R664	18.0143	3.21	No	No	0	5	7
66	R:R:A668	R:R:F665	13.5724	1.39	No	No	0	5	5
67	R:R:A668	R:R:R667	11.3357	4.15	No	No	0	5	5
68	R:R:L728	R:R:Y724	12.9686	3.52	No	Yes	0	7	8
69	R:R:F761	R:R:Y807	24.4408	9.28	Yes	Yes	0	5	8
70	R:R:F761	R:R:I762	18.4711	3.77	Yes	No	0	5	9
71	R:R:F743	R:R:I762	16.4601	1.26	Yes	No	0	8	9
72	R:R:F768	R:R:T771	10.7372	1.3	Yes	No	0	7	8
73	R:R:I815	R:R:M814	21.6371	1.46	Yes	No	0	8	8
74	R:R:M814	R:R:R821	18.0563	2.48	No	No	0	8	5
75	R:R:R837	R:R:Y834	13.2889	7.2	No	Yes	0	7	6
76	R:R:D839	R:R:R837	11.0469	3.57	No	No	0	5	7
77	R:R:L581	R:R:L612	11.3042	1.38	No	No	0	3	4
78	R:R:C647	R:R:M607	76.3467	3.24	Yes	Yes	0	7	8
79	R:R:D735	R:R:F641	21.9259	3.58	No	Yes	2	8	8
80	R:R:F768	R:R:N799	16.9904	3.62	Yes	No	2	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9NOY

PDB Summary
PDB	9NOY
Class	C
SubFamily	Sensory
Type	Taste1
SubType	TAS1R2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.7
Date	2025-04-09
D.O.I.	doi.org/10.1016/j.cell.2025.04.021

Net Summary
I_min	2.77
Number of Linked Nodes	233
Number of Links	260
Number of Hubs	34
Number of Links mediated by Hubs	126
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	44101
Length Of Smallest Path	3
Average Path Length	15.0685
Length of Longest Path	38
Minimum Path Strength	1.26
Average Path Strength	5.625
Maximum Path Strength	13.845
Minimum Path Correlation	0.7
Average Path Correlation	0.929533
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	45.9412
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.4195
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• sensory perception of sweet taste • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • regulation of cytokinesis • regulation of biological process • regulation of cellular process • positive regulation of cell division • regulation of cell cycle process • biological regulation • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cellular process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • response to stimulus • detection of chemical stimulus involved in sensory perception of sweet taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • response to chemical • detection of chemical stimulus • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein-containing complex • receptor complex • cellular anatomical structure • membrane • cell periphery • plasma membrane • taste receptor complex • sweet taste receptor complex
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TE23
Sequence	>9NOY_Chain_R L E W H E A P T I A V A L L A A L G F L S T L A I L V I F W R H F Q T P I V R S A G G P M C F L M L T L L L V A Y M V V P V Y V G P P K V S T C L C R Q A L F P L C F T I C I S C I A V R S F Q I V C A F K M A S R F P R A Y S Y W V R Y Q G P Y V S M A F I T V L K M V I V V I G M L A Y R N S L L F N T S L D L L L S V V G F S F A Y M G K E L P T N Y N E A K F I T L S M T F Y F T S S V S L C T F M S A Y S G V L V T I V D L L V T V L N L L A I S L G Y F G P K C Y M I L F Y P E R N T P A Y F N S M I Q G Y T M R R D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9NOX	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOX (No Gprot)	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOY	C	Sensory	Taste1	TAS1R2	Homo sapiens	-	-	-	3.7	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOR	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.4	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOS	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.5	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9NOT	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.8	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9O38 (No Gprot)	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-		3	2025-04-09	doi.org/10.1016/j.cell.2025.04.021
	9OQ0	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens; mus musculus	-	-	-	3.67	2025-08-27	To be published
	9UT8	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.41	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTA	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.77	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTB	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	Sucralose	-	-	3.59	2025-07-16	doi.org/10.1038/s41586-025-09302-6

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9NOY.zip

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