Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.825414
2A:A:H41 6.8675466
3A:A:L43 4.14467
4A:A:L44 9.195419
5A:A:L46 4.225418
6A:A:S51 54169
7A:A:K53 5.074169
8A:A:M60 5.905469
9A:A:L63 4.4075469
10A:A:I207 5.7875419
11A:A:F212 6.4825469
12A:A:F219 6.06668
13A:A:H220 8.2575417
14A:A:M221 4.81468
15A:A:F222 7.58517
16A:A:V224 5.945419
17A:A:Q227 7.2625419
18A:A:R228 6.935409
19A:A:R232 8.1625418
20A:A:K233 5.34714719
21A:A:W234 6.85833619
22A:A:F238 7.65143719
23A:A:I244 3.5875418
24A:A:I245 3.6425407
25A:A:D249 7.58254138
26A:A:S250 3.3725426
27A:A:D252 6.44254138
28A:A:Y253 7.28408
29A:A:R265 5.3225139
30A:A:L270 5.7775406
31A:A:F273 5.198529
32A:A:W277 10.268526
33A:A:W281 10.324515
34A:A:I285 2.595417
35A:A:L289 5.0825429
36A:A:N292 5.0425409
37A:A:Q294 7.0225426
38A:A:L296 4.225406
39A:A:L297 3.0875428
40A:A:F315 10.832526
41A:A:Y318 6.546526
42A:A:P321 4.77525
43A:A:D331 8.4775424
44A:A:V334 3.77833624
45A:A:K338 7.895425
46A:A:Y339 7.656523
47A:A:F340 11.5225427
48A:A:R342 7.686524
49A:A:F345 7.664528
50A:A:L346 5.4175424
51A:A:S349 5.0025427
52A:A:Y360 6.72667638
53A:A:F363 9.922525
54A:A:D381 9.0525438
55A:A:K385 9.9325435
56A:A:F394 6.01286735
57B:B:L4 3.035404
58B:B:L7 4.53408
59B:B:R22 5.32416
60B:B:T34 4.485485
61B:B:I37 4.468582
62B:B:V40 4.614583
63B:B:L51 7.89459
64B:B:H54 8.00333659
65B:B:K57 11.224519
66B:B:Y59 7.3125418
67B:B:W63 5.90167657
68B:B:V71 4.31754148
69B:B:Q75 10.7775419
70B:B:D76 6.076519
71B:B:K78 5.7775408
72B:B:I80 8.3075458
73B:B:I81 4.40254147
74B:B:W82 8.25286759
75B:B:D83 10.41754128
76B:B:T86 7.94126
77B:B:N88 6.8254127
78B:B:K89 5.85667659
79B:B:I93 6.4725407
80B:B:L95 4.5365158
81B:B:W99 7.44143719
82B:B:Y105 4.235717146
83B:B:N110 6.8525414
84B:B:Y111 6.99414
85B:B:L117 4.53286719
86B:B:I123 4.035416
87B:B:Y124 6.2425156
88B:B:L126 4.55754145
89B:B:L139 7.48409
90B:B:H142 6.51857719
91B:B:Y145 6.93857718
92B:B:L146 4.0875417
93B:B:F151 4.55571719
94B:B:L152 5.2925403
95B:B:I157 4.358517
96B:B:T159 4.945619
97B:B:D163 9.7875419
98B:B:W169 8.75667618
99B:B:Q176 6.605414
100B:B:F180 8.144547
101B:B:H183 7.725649
102B:B:D186 7.015419
103B:B:V187 4.766549
104B:B:L190 5.0025445
105B:B:F199 7.572549
106B:B:V200 5.6025416
107B:B:S201 4.915449
108B:B:C204 4.44667617
109B:B:D205 6.6775449
110B:B:S207 4.1725445
111B:B:K209 9.04333646
112B:B:W211 8.30333648
113B:B:D212 8.29754189
114B:B:Q220 8.0475417
115B:B:F222 7.594518
116B:B:H225 8.45833619
117B:B:S227 3.76416
118B:B:D228 8.068519
119B:B:I232 5.4775418
120B:B:F234 5.08405
121B:B:F235 6.6565116
122B:B:P236 6.7254117
123B:B:F241 6.632516
124B:B:T243 5.8975418
125B:B:D246 4.8225419
126B:B:D247 6.86619
127B:B:T249 7.8625416
128B:B:R251 7.75286718
129B:B:F253 7.235616
130B:B:D258 8.6275417
131B:B:Q259 4.206516
132B:B:M262 5.4825404
133B:B:Y264 6.176505
134B:B:H266 8.445414
135B:B:I269 3.164514
136B:B:F278 5.694297117
137B:B:R283 8.114589
138B:B:L284 4.7425405
139B:B:Y289 6.69717
140B:B:D290 5.66516
141B:B:N295 6.556516
142B:B:W297 5.2325418
143B:B:L300 5.625486
144B:B:K301 7.1475405
145B:B:R304 5.772515
146B:B:L308 8.085477
147B:B:H311 7.95679
148B:B:R314 8.60167618
149B:B:L318 3.32506
150B:B:V327 3.464506
151B:B:W332 9.87857719
152B:B:D333 8.3625479
153B:B:L336 4.208557
154B:B:K337 7.3625476
155B:B:W339 8.43833679
156G:G:R27 5.49518
157G:G:Y40 11.19754116
158G:G:D48 8.0275409
159G:G:L50 4.325409
160G:G:L51 4.882586
161R:R:T593 6.535499
162R:R:I595 7.29497
163R:R:M607 3.645408
164R:R:Y615 4.9975408
165R:R:V618 3.94407
166R:R:C640 3.28407
167R:R:F641 6.55254228
168R:R:I643 3.214507
169R:R:F659 6.64833639
170R:R:W672 10.6754236
171R:R:P678 7.50254238
172R:R:K689 6.588509
173R:R:I695 1.945404
174R:R:V741 2.025404
175R:R:F743 4.295408
176R:R:L752 3.868538
177R:R:P753 7.2875439
178R:R:Y756 5.93714739
179R:R:F761 6.5225405
180R:R:Y769 9.27754228
181R:R:I790 2.9225408
182R:R:Y807 10.506508
183R:R:F808 7.641676209
184R:R:I815 5.425498
185R:R:Y818 4.52406
186R:R:F827 8.858537
187R:R:N828 9.0825436
188R:R:M830 5.0175404
189R:R:Q832 4.632538
190R:R:Y834 7.87167636
191R:R:T835 5.3725437
192S:S:L572 3.0025408
193S:S:F590 4.8445109
194S:S:L598 6.5025407
195S:S:L611 7.55254109
196S:S:V621 6.3725407
197S:S:P643 3.9075406
198S:S:L644 3.26408
199S:S:L653 3.1875407
200S:S:L664 2.675406
201S:S:Y699 6.3645266
202S:S:F703 3.65505
203S:S:N737 4.75407
204S:S:F745 5.89409
205S:S:Y758 6.80754259
206S:S:R762 5.28409
207S:S:M768 4.7825409
208S:S:W775 9.95409
209S:S:F778 4.8475409
210S:S:M795 5.355407
211S:S:L806 3.4925408
212S:S:F809 8.016508
213S:S:H810 9.34754109
214S:S:R813 7.3875409
215S:S:F829 6.366256
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:R280 A:A:W281 59.404615.99NoYes055
2A:A:R280 A:A:R283 59.40487.46NoNo053
3A:A:R283 A:A:R356 59.40538.53NoNo032
4A:A:H357 A:A:R356 59.41927.9NoNo072
5A:A:H357 A:A:W277 59.381828.56NoYes276
6A:A:S349 A:A:W277 58.10728.65YesYes276
7A:A:L346 A:A:S349 58.083YesYes247
8A:A:L346 A:A:R342 58.09627.29YesYes244
9A:A:F363 A:A:R342 57.98328.55YesYes254
10A:A:F363 A:A:Q294 78.586912.88YesYes256
11A:A:Q294 A:A:T364 99.87482.83YesNo069
12A:A:N292 A:A:T364 99.86647.31YesNo099
13A:A:N292 A:A:V247 1004.43YesNo097
14A:A:K53 A:A:V247 99.80423.04YesNo1697
15A:A:K53 A:A:L45 99.92652.82YesNo098
16A:A:L45 A:A:M221 35.77362.83NoYes088
17A:A:L43 A:A:M221 17.98935.65YesYes678
18A:A:F219 A:A:L43 34.02233.65YesYes687
19A:A:F238 A:A:W234 11.4454.01YesYes199
20A:A:R231 A:A:W234 39.11779NoYes099
21A:A:D272 A:A:R231 39.639211.91NoNo089
22A:A:D272 A:A:F246 39.6295.97NoNo089
23A:A:F246 A:A:F345 39.57863.22NoYes298
24A:A:F345 A:A:L289 41.07518.53YesYes289
25A:A:L289 A:A:L291 41.13965.54YesNo098
26A:A:F363 A:A:L291 20.37267.31YesNo058
27A:A:L291 A:A:S250 20.81314.5NoYes086
28A:A:Q294 A:A:S250 20.88492.89YesYes266
29A:A:I245 A:A:L45 64.14744.28YesNo078
30A:A:I245 A:A:L43 17.99984.28YesYes077
31A:A:F212 A:A:M221 17.38074.98YesYes698
32A:A:F212 A:A:F219 17.12819.65YesYes698
33A:A:F219 A:A:F376 48.21574.29YesNo088
34B:B:H142 B:B:S161 10.649615.34YesNo199
35B:B:G162 B:B:S161 11.70563.71NoNo199
36B:B:G162 B:B:Y145 11.713310.14NoYes198
37A:A:W234 B:B:Y145 27.2955.79YesYes198
38A:A:K233 B:B:Y145 18.33613.58YesYes198
39A:A:I245 A:A:I288 46.12152.94YesNo079
40A:A:W281 B:B:D290 31.84738.93YesYes156
41A:A:A378 A:A:I288 46.063.25NoNo079
42A:A:A378 A:A:Y360 46.03014NoYes078
43A:A:Y358 A:A:Y360 15.03777.94NoYes348
44A:A:Y358 R:R:N828 15.083218.61NoYes346
45A:A:D381 A:A:Y360 30.16826.9YesYes388
46A:A:F376 A:A:T380 48.08166.49NoNo086
47A:A:I384 A:A:T380 42.86123.04NoNo366
48A:A:D381 A:A:K385 28.610113.83YesYes385
49A:A:I384 R:R:F659 42.73355.02NoYes369
50A:A:F394 R:R:N828 15.00144.83YesYes356
51A:A:F394 A:A:K385 14.99637.44YesYes355
52A:A:K385 R:R:I831 13.57557.27YesNo357
53R:R:F659 R:R:Y756 40.5099.28YesYes399
54A:A:F394 R:R:Y756 27.08673.09YesYes359
55R:R:I831 R:R:Y756 13.53464.84NoYes379
56R:R:I655 R:R:Y756 80.61196.04NoYes099
57B:B:L318 B:B:V327 54.16012.98YesYes066
58B:B:V327 G:G:L50 54.53162.98YesYes069
59B:B:N340 G:G:L50 62.45892.75NoYes099
60B:B:N340 B:B:R48 62.247812.05NoNo097
61B:B:R46 B:B:R48 62.14235.33NoNo057
62B:B:R46 S:S:P821 61.71974.32NoNo059
63B:B:D247 B:B:S227 14.27032.94YesYes196
64B:B:D247 B:B:R251 10.31973.57YesYes198
65B:B:L318 B:B:S275 57.79014.5YesNo068
66B:B:R314 B:B:T274 30.17456.47YesNo188
67B:B:S275 B:B:T274 57.86643.2NoNo088
68R:R:I655 R:R:R651 80.43693.76NoNo099
69R:R:E758 R:R:R651 36.09796.98NoNo099
70R:R:E758 R:R:F761 35.8164.66NoYes095
71R:R:F761 R:R:I803 66.02383.77YesNo058
72R:R:I803 R:R:N799 64.93052.83NoNo089
73R:R:N799 R:R:S772 17.12122.98NoNo099
74R:R:S772 R:R:V795 14.83983.23NoNo098
75R:R:L776 R:R:V795 13.69954.47NoNo098
76R:R:L776 R:R:M780 11.99525.65NoNo098
77R:R:M780 R:R:V788 10.85344.56NoNo087
78R:R:V788 R:R:Y783 10.28256.31NoNo078
79R:R:R651 R:R:Y807 44.06127.2NoYes098
80R:R:F761 R:R:Y807 35.879912.38YesYes058
81R:R:N799 R:R:Y769 47.30919.3NoYes098
82R:R:F641 R:R:Y769 41.049611.35YesYes2288
83R:R:F641 R:R:L800 31.38316.09YesNo088
84R:R:C640 R:R:L800 21.12393.17YesNo078
85R:R:C640 R:R:L610 19.4133.17YesNo078
86R:R:I643 R:R:L610 18.84264.28YesNo078
87S:S:P821 S:S:Q820 61.61411.58NoNo096
88S:S:L816 S:S:Q820 61.40255.32NoNo086
89S:S:L598 S:S:L816 30.76364.15YesNo078
90S:S:L598 S:S:R813 29.54564.86YesYes079
91S:S:F809 S:S:R813 57.70618.55YesYes089
92S:S:F809 S:S:H810 20.835214.71YesYes089
93S:S:H810 S:S:L806 17.82653.86YesYes098
94S:S:L816 S:S:Y758 30.53323.52NoYes089
95S:S:R813 S:S:Y758 29.53668.23YesYes099
96R:R:I643 R:R:T642 16.56073.04YesNo078
97R:R:K689 R:R:T642 14.278218.02YesNo098
98S:S:F809 S:S:L764 35.61594.87YesNo089
99S:S:C744 S:S:L764 26.59564.76NoNo089
100S:S:C744 S:S:M768 26.14128.1NoYes089
101S:S:L648 S:S:M768 10.48172.83NoYes079
102S:S:L644 S:S:L648 10.2522.77YesNo087
103S:S:F745 S:S:F749 12.10569.65YesNo098
104S:S:F749 S:S:L750 11.64048.53NoNo088
105S:S:E663 S:S:L750 11.17526.63NoNo068
106B:B:S279 G:G:L50 10.28334.5NoYes099
107A:A:W281 B:B:R314 26.073712YesYes158
108B:B:D290 B:B:T274 27.77192.89YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9O38
Class C
SubFamily Sensory
Type Taste1
SubType TAS1R2; TAS1R3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGt3)/Beta1/Gamma2
PDB Resolution 3
Date 2025-04-09
D.O.I. doi.org/10.1016/j.cell.2025.04.021
Net Summary
Imin 2.82
Number of Linked Nodes 1062
Number of Links 1298
Number of Hubs 215
Number of Links mediated by Hubs 767
Number of Communities 27
Number of Nodes involved in Communities 268
Number of Links involved in Communities 405
Path Summary
Number Of Nodes in MetaPath 109
Number Of Links MetaPath 108
Number of Shortest Paths 7508364
Length Of Smallest Path 3
Average Path Length 43.176
Length of Longest Path 80
Minimum Path Strength 1.225
Average Path Strength 6.33291
Maximum Path Strength 18.86
Minimum Path Correlation 0.7
Average Path Correlation 0.996813
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 34.243
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.4273
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• sensory perception of sweet taste   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • response to stimulus   • detection of chemical stimulus involved in sensory perception of sweet taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • response to chemical   • detection of chemical stimulus   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • protein-containing complex   • receptor complex   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • taste receptor complex   • sweet taste receptor complex   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled receptor activity   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • sensory perception of umami taste   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9O38_Chain_A
EDQRNEEKA QREANKKIE KQLQKDKQV YRATHRLLL LGASGKSTI 
VKQMRILHS GIFETKFQV DKVNFHMFD VGGQRDERR KWIQCFNDV 
TAIIFVVSS YNRLQEALN FKSIWNNRW LRTISVILF LNKQDLLAE 
KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT RAKYFIRDE 
FLRISTASG DGRHYCYPH FTCAVDTNV FDIILLDNG GSDDDQVKF 
DAVTIKENK DCGF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9O38_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9O38_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASEN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TE23
Sequence
>9O38_Chain_R
LPCLVLEWH EAPTIAVAL LAALGFLST LAILVIFWR HFQTPIVRS 
AGGPMCFLM LTLLVAYMV VPVYVGPPK VSTCLCRQA LFLCFTICI 
SIAVRSFQI VCAFKMASR FPRAYSYWV RYQGPYVSM AFITVLKMV 
IVVIGMLAY RNSLLFNTS LDLLLSVVG FSFAYMGKE LPTNYNEAK 
FITSMTFYF TSSVSLCTF MSAYSGVLT IVDLLVTVL NLLAISLGY 
FGPKCYMIL FYPERNTPA YFNSMIQGY TMRRD


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ7RTX0
Sequence
>9O38_Chain_S
EPAVLLLLL LLSLALGLV LAALGLFVH HRDSPLVQA SGGPLACFG 
LVCLGLVCL SVLLFPGQP SPARCLAQQ PLSHLPLTG CLSTLFLQA 
AEIFVESEL PLSWADRLS GCLRGPWAW LVVLLAMLV EVALCTWYL 
VAFPWVSFG LAHATNATL AFLCFLGTF LVRSQPGYN RARGLTFAM 
LAYFITWVS FVPLLANVQ VVLRPAVQM GALLLCVLG ILAAFHLPR 
CYLLMRQPG LNTPEFFLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9NOXCSensoryTaste1TAS1R2Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOX (No Gprot) CSensoryTaste1TAS1R2Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOYCSensoryTaste1TAS1R2Homo sapiens---3.72025-04-09doi.org/10.1016/j.cell.2025.04.021
9NORCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.42025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOSCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.52025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOTCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.82025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38 (No Gprot) CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9OQ0CSensoryTaste1TAS1R2; TAS1R3Homo sapiens; mus musculus---3.672025-08-27To be published
9UT8CSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.412025-07-16doi.org/10.1038/s41586-025-09302-6
9UTACSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.772025-07-16doi.org/10.1038/s41586-025-09302-6
9UTBCSensoryTaste1TAS1R2; TAS1R3Homo sapiensSucralose--3.592025-07-16doi.org/10.1038/s41586-025-09302-6




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