Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y33 4.8356265
2R:R:L38 3.7765277
3R:R:F39 4.36167638
4R:R:L41 4.322535
5R:R:M72 5.316535
6R:R:R76 6.388535
7R:R:F77 5.302538
8R:R:L88 2.96438
9R:R:Y96 8.76438
10R:R:I98 4.35437
11R:R:D100 6.0675438
12R:R:P110 4.9354275
13R:R:L115 4.775405
14R:R:L122 4.34484
15R:R:P123 3.638583
16R:R:Y128 5.68167684
17R:R:Y131 7.208584
18R:R:P141 3.922506
19R:R:V147 2.85518
20R:R:F153 3.845424
21R:R:L154 4.832526
22R:R:F157 6.9575487
23R:R:L158 2.605484
24R:R:L159 5.9775426
25R:R:P160 2.756528
26R:R:Y164 5.5225407
27R:R:R172 5.595418
28R:R:L181 4.586516
29R:R:R182 4.86167619
30R:R:T183 3.054519
31R:R:S186 3.5275418
32R:R:H189 5.512514
33R:R:E192 6.066513
34R:R:F201 7.094118
35R:R:W203 5.2585119
36R:R:W205 4.968758149
37R:R:V210 2.438514
38R:R:S211 4.3775417
39R:R:D213 4.0075416
40R:R:Y215 4.49167617
41R:R:G216 2.07418
42R:R:R217 4.286676336
43R:R:G220 2.065414
44R:R:L223 3.53616
45R:R:R226 5.11414
46R:R:R230 3.94414
47R:R:F236 4.7825186
48R:R:E238 3.53754185
49R:R:V261 3.6025415
50R:R:F275 5.03625818
51R:R:S276 3.51514
52R:R:P277 2.9875415
53R:R:L281 4.7425414
54R:R:F284 4.7525414
55R:R:F285 4.4575414
56R:R:E287 4.3875415
57R:R:F293 3.996513
58R:R:W298 7.09418
59R:R:S301 3.785418
60R:R:W304 5.28889917
61R:R:D307 3.435415
62R:R:L310 4.2225413
63R:R:H311 5.5275414
64R:R:G324 1.875408
65R:R:T326 4.44415
66R:R:F338 5.9625438
67R:R:R383 3.4525415
68R:R:Y386 6.76333637
69R:R:Y389 5.20333638
70R:R:Y393 6.94638
71R:R:Y416 7.65584
72R:R:W418 6.99833683
73R:R:W425 4.13415
74R:R:F429 7.41833639
75R:R:L431 4.866537
76R:R:F438 5.3525418
77R:R:D439 6.635418
78R:R:G442 1.97417
79R:R:D443 7.1775418
80R:R:E449 8.2407
81R:R:I450 3.6154328
82R:R:Q452 3.1154118
83R:R:W453 4.695615
84R:R:F462 6.176514
85R:R:Y468 5.382515
86R:R:W483 7.211437118
87R:R:P491 6.7954119
88R:R:C495 4.874149
89R:R:Q503 8.6154136
90R:R:K504 4.0725405
91R:R:C513 3.0485149
92R:R:C514 3.6854149
93R:R:D519 8.79754134
94R:R:C520 3.8454139
95R:R:L526 2.5875408
96R:R:C538 4.5885289
97R:R:W543 7.425407
98R:R:S579 3.6675464
99R:R:I583 3.035457
100R:R:F587 4.6375459
101R:R:I595 4.1275457
102R:R:F605 5.06456
103R:R:Y615 5.51468
104R:R:V620 2.6406
105R:R:R633 11.865498
106R:R:Q634 5.942598
107R:R:F641 5.34468
108R:R:R651 3.556559
109R:R:I655 4.444559
110R:R:M661 6.715407
111R:R:Y669 7.855407
112R:R:T686 3.068507
113R:R:D709 10.5254363
114R:R:V718 4.05407
115R:R:C720 5.724599
116R:R:N721 3.644596
117R:R:P722 5.0525496
118R:R:L734 2.8725468
119R:R:D735 4.8425468
120R:R:S739 3.2525408
121R:R:F743 4.6575408
122R:R:Y756 9.802559
123R:R:E758 10.08459
124R:R:L776 4.7054309
125R:R:F779 4.625407
126R:R:M780 5.9585308
127R:R:V788 6.11754307
128R:R:D792 3.834309
129R:R:L800 5.71468
130R:R:L801 4.055466
131R:R:S804 4.234568
132R:R:Y807 6.71458
133R:R:F808 7.085459
134R:R:L816 3.9325456
135R:R:R821 8.485405
136R:R:F827 5.966557
137S:S:L25 3.18254434
138S:S:S26 5.218575
139S:S:Q27 5.945475
140S:S:Y35 3.08254215
141S:S:F41 4.2725128
142S:S:L43 2.225405
143S:S:P57 3.945485
144S:S:F65 4.7825474
145S:S:L70 3.09476
146S:S:W72 5.592867125
147S:S:M76 3.3745128
148S:S:Y97 7.5375408
149S:S:D98 4.24254445
150S:S:L99 3.395127
151S:S:F100 8.86754444
152S:S:T102 3.12426
153S:S:V107 2.555404
154S:S:K111 4.6075485
155S:S:L114 3.9125425
156S:S:F116 4.67405
157S:S:L117 4.97424
158S:S:D124 2.0725401
159S:S:P144 3.5425
160S:S:H145 8.2154125
161S:S:F156 5.6125424
162S:S:F157 4.56627
163S:S:F160 9.5625425
164S:S:M162 3.48333626
165S:S:P163 3.09527
166S:S:Q164 5.115627
167S:S:Y167 6.1365127
168S:S:G168 2.944125
169S:S:E172 7.85425
170S:S:L174 5.9625428
171S:S:S175 4.6825429
172S:S:F180 5.596526
173S:S:F183 5.196528
174S:S:F184 6.03406
175S:S:R185 3.892529
176S:S:P188 4.045447
177S:S:L194 3.02426
178S:S:E203 3.925445
179S:S:F204 5.52748
180S:S:W206 7.116549
181S:S:W208 5.386676199
182S:S:S214 4.305427
183S:S:I225 3.0925423
184S:S:R233 2.52404
185S:S:E240 5.5054185
186S:S:V270 4.56449
187S:S:L273 4.178525
188S:S:F274 4.82714727
189S:S:F284 4.97333624
190S:S:Y286 5.55406
191S:S:W297 6.325428
192S:S:S300 2.97528
193S:S:W303 6.15627
194S:S:L304 3.2925406
195S:S:L312 4.482502
196S:S:F324 4.0725446
197S:S:Q326 3.5175444
198S:S:F334 3.3745227
199S:S:Y337 7.1275477
200S:S:F350 8.73475
201S:S:L354 5.202576
202S:S:Q368 6.5975473
203S:S:C370 5.365478
204S:S:C373 4.145474
205S:S:Q389 5.2165124
206S:S:F391 3.14754226
207S:S:Y394 7.6225228
208S:S:Y398 6.186508
209S:S:L404 4.0685217
210S:S:H405 3.764237
211S:S:L408 4.272504
212S:S:V421 3.4765213
213S:S:P423 5.015426
214S:S:L426 3.21254216
215S:S:F435 4.696239
216S:S:V437 3.7475406
217S:S:Y454 3.265648
218S:S:D455 7.4854247
219S:S:K457 6.274245
220S:S:W459 8.9675406
221S:S:R473 5.23754243
222S:S:F474 4.1625446
223S:S:L478 3.11547
224S:S:I485 7.3425446
225S:S:W487 5.93648
226S:S:H488 4.192544
227S:S:P495 4.498547
228S:S:Q507 5.614487
229S:S:R509 3.465407
230S:S:H515 4.8085186
231S:S:S528 3.73754497
232S:S:C541 4.364159
233S:S:E545 6.394156
234S:S:S547 5.53254158
235S:S:C554 7.3865159
236S:S:F561 7.7454316
237S:S:E566 4.354537
238S:S:V569 2.6454537
239S:S:V583 2.6954167
240S:S:F590 3.3225409
241S:S:S596 3.4775409
242S:S:L611 5.2425409
243S:S:C613 1.9054168
244S:S:L614 3.6354169
245S:S:P628 4.02254319
246S:S:Q637 5.874178
247S:S:P638 3.94254175
248S:S:H641 6.7125105
249S:S:L642 5.3825407
250S:S:F652 4.175408
251S:S:V660 6.29406
252S:S:Y699 4.6356176
253S:S:P705 2.678336178
254S:S:D710 4.9854527
255S:S:W711 8.8854503
256S:S:T716 4.84254514
257S:S:L719 4.964527
258S:S:W727 4.2775403
259S:S:H734 6.3145107
260S:S:N737 6.5975407
261S:S:F745 3.244419
262S:S:F749 4.2845418
263S:S:T765 3.844419
264S:S:M768 3.755409
265S:S:Y771 10.70754108
266S:S:W775 6.346679109
267S:S:F778 4.8754109
268S:S:V779 4.395406
269S:S:L782 3.415408
270S:S:M795 5.06254547
271S:S:L798 2.22254108
272S:S:L806 3.81254168
273S:S:F809 5.3325408
274S:S:H810 5.9154169
275S:S:R813 6.13409
276S:S:L817 4.0285258
277S:S:Q820 4.474256
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:A300 R:R:W304 17.943611.67NoYes067
2R:R:A300 R:R:G324 17.91741.95NoYes068
3R:R:E449 R:R:Q328 10.26317.84YesNo075
4R:R:H447 R:R:Q328 10.20483.71NoNo045
5R:R:Q161 R:R:V150 29.02375.73NoNo087
6R:R:P141 R:R:V147 15.2623.53YesYes068
7R:R:Q161 R:R:V147 30.58812.87NoYes088
8R:R:L115 R:R:L154 21.55094.15YesYes056
9R:R:L115 R:R:L122 10.52672.77YesYes054
10R:R:T163 R:R:V147 22.91673.17NoYes188
11R:R:L171 R:R:V147 22.94322.98NoYes078
12R:R:R182 R:R:T163 24.46713.88YesNo198
13R:R:L171 R:R:R182 25.08423.64NoYes079
14R:R:G324 R:R:I325 12.95711.76YesNo087
15R:R:H190 R:R:I325 12.79463.98NoNo097
16R:R:E302 R:R:H190 25.66136.15NoNo089
17R:R:R182 R:R:S186 28.68152.64YesYes198
18R:R:D188 R:R:S186 33.20895.89NoYes138
19R:R:D443 R:R:G442 10.40931.68YesYes187
20R:R:P185 R:R:T184 30.47613.5NoNo087
21R:R:H189 R:R:P185 30.62324.58YesNo048
22R:R:H189 R:R:Y468 51.10498.71YesYes145
23R:R:H189 R:R:R473 13.28113.39YesNo044
24R:R:H190 R:R:L448 38.35585.14NoNo098
25R:R:F275 R:R:I191 26.15542.51YesNo186
26R:R:E192 R:R:Y468 13.43566.73YesYes135
27R:R:E192 R:R:R226 26.217710.47YesYes134
28R:R:E192 R:R:R473 13.29916.98YesNo034
29R:R:I191 R:R:R226 26.3412.51NoYes164
30R:R:F322 R:R:W298 76.134614.03NoYes178
31R:R:F322 R:R:W304 69.62274.01NoYes177
32R:R:A269 R:R:W205 99.88156.48NoYes1479
33R:R:A269 R:R:I207 99.89223.25NoNo078
34R:R:I207 R:R:V272 77.69423.07NoNo086
35R:R:V272 R:R:W298 77.6616.13NoYes068
36R:R:C495 R:R:W205 49.95865.22YesYes1499
37R:R:C514 R:R:W205 49.95863.92YesYes1499
38R:R:F236 R:R:I207 22.844313.82YesNo068
39R:R:S301 R:R:W304 38.99572.47YesYes187
40R:R:S301 R:R:Y215 12.91283.82YesYes187
41R:R:S303 R:R:W304 12.93684.94NoYes157
42R:R:S303 R:R:Y215 12.91487.63NoYes157
43R:R:E302 R:R:Y215 25.82994.49NoYes087
44R:R:E238 R:R:F236 22.00122.33YesYes1856
45R:R:E238 S:S:H515 22.04593.69YesYes1856
46R:R:C495 R:R:S496 50.0135.16YesNo1498
47R:R:C514 R:R:S496 50.0131.72YesNo1498
48R:R:F515 R:R:S496 1009.25NoNo078
49R:R:C499 R:R:F515 99.55672.79NoNo097
50R:R:C499 R:R:Q503 99.48943.05NoYes1396
51R:R:D519 R:R:Q503 99.451810.44YesYes1346
52R:R:C520 R:R:D519 99.37311.56YesYes1394
53R:R:C520 R:R:K504 49.67354.85YesYes095
54R:R:K504 R:R:L526 49.57232.82YesYes058
55R:R:C520 R:R:C535 49.59127.28YesNo1399
56R:R:C535 R:R:L526 49.57233.17NoYes098
57R:R:E532 R:R:L526 98.84522.65NoYes068
58R:R:E532 R:R:H528 98.77033.69NoNo064
59R:R:H528 R:R:T529 98.69544.11NoNo046
60R:R:E530 R:R:T529 98.53839.88NoNo3546
61R:R:E530 R:R:Q536 98.47072.55NoNo041
62R:R:F525 R:R:Q536 98.395710.54NoNo071
63R:R:C538 R:R:F525 98.32084.19YesNo097
64R:R:C538 R:R:S544 97.93863.44YesNo2898
65R:R:G523 R:R:S544 97.88541.86NoNo078
66R:R:G523 R:R:W543 97.81035.63NoYes077
67R:R:P713 R:R:W543 95.02484.05NoYes047
68R:R:D712 R:R:P713 94.94936.44NoNo044
69R:R:D711 R:R:D712 94.72272.66NoNo054
70R:R:F779 R:R:M780 72.34524.98YesYes078
71R:R:M780 R:R:V788 73.63959.13YesYes3087
72R:R:N723 R:R:V788 37.44215.91NoYes057
73R:R:N723 R:R:R707 56.60442.41NoNo056
74R:R:I717 R:R:R707 94.19345.01NoNo066
75R:R:I717 R:R:V786 94.26914.61NoNo068
76R:R:D709 R:R:V786 94.34477.3YesNo038
77R:R:D709 R:R:D711 94.481919.96YesNo3635
78R:R:V788 R:R:Y783 37.35845.05YesNo078
79R:R:R707 R:R:Y783 37.51645.14NoNo068
80R:R:N723 R:R:S719 19.26328.94NoNo055
81R:R:C720 R:R:S719 17.90621.72YesNo995
82R:R:C720 R:R:Q634 17.16726.1YesYes998
83R:R:M697 R:R:Q634 17.01892.72NoYes078
84R:R:M697 R:R:V693 16.60844.56NoNo077
85R:R:K689 R:R:V693 16.52634.55NoNo097
86R:R:K689 R:R:T642 15.953218.02NoNo098
87R:R:D735 R:R:T642 15.62218.67YesNo688
88R:R:D735 R:R:F641 14.41882.39YesYes688
89R:R:F779 S:S:W727 71.06023.01YesYes073
90S:S:F730 S:S:W727 42.2454.01NoYes073
91S:S:F730 S:S:H734 31.97774.53NoYes077
92S:S:H734 S:S:W775 27.33958.46YesYes1079
93S:S:W775 S:S:Y771 41.255422.19YesYes1098
94S:S:F772 S:S:Y771 40.94345.16NoYes068
95S:S:A741 S:S:F772 39.95314.16NoNo086
96S:S:A741 S:S:M768 39.62323.22NoYes089
97S:S:F745 S:S:M768 15.88612.49YesYes099
98S:S:V779 S:S:W727 28.49154.9YesYes063
99S:S:F778 S:S:V779 27.67562.62YesYes096
100S:S:F778 S:S:W775 27.43228.02YesYes1099
101S:S:F745 S:S:T765 12.95623.89YesYes4199
102S:S:T748 S:S:T765 12.34236.28NoYes099
103S:S:A761 S:S:T748 12.0093.36NoNo099
104S:S:H515 S:S:I237 21.65162.65YesNo065
105S:S:I237 S:S:V209 21.58753.07NoNo057
106S:S:V209 S:S:V270 21.42943.21NoYes079
107S:S:V270 S:S:W206 21.26818.58YesYes499
108S:S:F204 S:S:W206 15.41712.03YesYes489
109S:S:I485 S:S:L458 10.41054.28YesNo067
110S:S:L322 S:S:L458 10.34054.15NoNo067
111S:S:G323 S:S:L322 10.20191.71NoNo076
112S:S:G323 S:S:L304 10.14145.13NoYes076
113S:S:F730 S:S:L782 10.11642.44NoYes078
114S:S:Q794 S:S:W775 11.35242.19NoYes1089
115S:S:F624 S:S:Q794 11.023912.88NoNo078
116S:S:F624 S:S:Q636 10.356429.28NoNo078
117S:S:Q636 S:S:Q637 10.022611.52NoYes088
118S:S:L651 S:S:M768 21.0442.83NoYes079
119S:S:F809 S:S:L651 20.37852.44YesNo087
120S:S:F809 S:S:R813 11.00288.55YesYes089
121R:R:R182 R:R:T184 28.68042.59YesNo097
122R:R:D188 R:R:H189 33.66926.3NoYes134
123R:R:L448 R:R:Y468 38.27174.69NoYes085
124R:R:F275 R:R:S301 26.08073.96YesYes188
125R:R:L154 R:R:V150 21.07022.98YesNo267
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9UT8
Class C
SubFamily Sensory
Type Taste1
SubType TAS1R2; TAS1R3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.41
Date 2025-07-16
D.O.I. doi.org/10.1038/s41586-025-09302-6
Net Summary
Imin 1.68
Number of Linked Nodes 1462
Number of Links 1778
Number of Hubs 277
Number of Links mediated by Hubs 972
Number of Communities 57
Number of Nodes involved in Communities 478
Number of Links involved in Communities 666
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 18225280
Length Of Smallest Path 3
Average Path Length 62.8954
Length of Longest Path 87
Minimum Path Strength 1.22
Average Path Strength 5.88587
Maximum Path Strength 21.08
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 57.4387
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.9603
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• sensory perception of sweet taste   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory perception of umami taste   • response to stimulus   • detection of chemical stimulus involved in sensory perception of sweet taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • response to chemical   • detection of chemical stimulus   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • Golgi apparatus   • organelle   • cytoplasm   • intracellular membrane-bounded organelle   • endomembrane system   • cell periphery   • plasma membrane   • protein-containing complex   • taste receptor complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • Golgi apparatus   • organelle   • cytoplasm   • intracellular membrane-bounded organelle   • endomembrane system   • cell periphery   • plasma membrane   • protein-containing complex   • taste receptor complex   • sweet taste receptor complex   • receptor complex   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled receptor activity   • sweet taste receptor activity   • sensory perception of sweet taste   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • regulation of cytokinesis   • regulation of biological process   • regulation of cellular process   • positive regulation of cell division   • regulation of cell cycle process   • biological regulation   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cellular process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • response to stimulus   • detection of chemical stimulus involved in sensory perception of sweet taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • response to chemical   • detection of chemical stimulus   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • cellular response to stimulus   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TE23
Sequence
>9UT8_Chain_R
DFYLPGDYL LGGLFSLHA NMCKEYEVK VIGYNLMQA MRFAVEEIN 
NDSSLLPGV LLGYEIVDV CYISNNVQP VLYFLAHED NLLPIQEDY 
SNYISRVVA VIGPDNSES VMTVANFLS LFLLPQITY SAISDELRD 
KVRFPALLR TTPSADHHI EAMVQLMLH FRWNWIIVL VSSDTYGRD 
NGQLLGERV ARRDICIAF QETLPTLQP NQNMTSEER QRLVTIVDK 
LQQSTARVV VVFSPDLTL YHFFNEVLR QNFTGAVWI ASESWAIDP 
VLHNLTELR HLGTFLGIT IQSVPIPGF SEFREWLNA TLSFNTILR 
LSGERVVYS VYSAVYAVA HALHSLLGC DKSTCTKRV VYPWQLLEE 
IWKVNFTLL DHQIFFDPQ GDVALHLEI VQWQWDRSQ NPFQSVASY 
YPLQRQLKN IQDISWHTI NNTIPMSMC SKRCQSGQK KKPVGIHVC 
CFECIDCLP GTFLNHTED EYECQACPN NEWSYQSET SCFKRQLVF 
LEWHEAPTI AVALLAALG FLSTLAILV IFWRHFQTP IVRSAGGPM 
CFLMLTLLL VAYMVVPVY VGPPKVSTC LCRQALFPL CFTICISCI 
AVRSFQIVC AFKMASRFP RAYSYWVRY QGPYVSMAF ITVLKMVIV 
VIGMLATGL SPTTRTDPD DPKITIVSC NPNYRNSLL FNTSLDLLL 
SVVGFSFAY MGKELPTNY NEAKFITLS MTFYFTSSV SLCTFMSAY 
SGVLVTIVD LLVTVLNLL AISLGYFGP KCYMILFYP ERNTPAYFN 
SMIQG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ7RTX0
Sequence
>9UT8_Chain_S
LCLSQQLRM KGDYVLGGL FPLGEAESR TRPSSPVCT RFSSNGLLW 
ALAMKMAVE EINNKSDLL PGLRLGYDL FDTCSEPVV AMKPSLMFL 
AKAGSRDIA AYCNYTQYQ PRVLAVIGP HSSELAMVT GKFFSFFLM 
PQVSYGASM ELLSARETF PSFFRTVPS DRVQLTAAA ELLQEFGWN 
WVAALGSDD EYGRQGLSI FSALAAARG ICIAHEGLV PLPRALGKV 
QDVLHQVNQ SSVQVVLLF ASVHAAHAL FNYSISSRL SPKVWVASE 
AWLTSDLVM GLPGMAQMG TVLGFLQRG AQLHEFPQY VKTHLALAT 
DPAFCSALG EQRCPQCDC ITLQNVSAG LNHHQTFSV YAAVYSVAQ 
ALHNTLQCN ASGCPAQDP VKPWQLLEN MYNLTFHVG GLPLRFDSS 
GNVDMEYDL KLWVWQGSV PRLHDVGRF NGSLRTERL KIRWHTSDN 
QKPVSRCSR QCQEGQVRR VKGFHSCCY DCVDCEAGS YRQNPDDIA 
CTFCGQDEW SPERSTRCF RRRSRFLAW GEPAVLLLL LLLSLALGL 
VLAALGLFV HHRDSPLVQ ASGGPLACF GLVCLGLVC LSVLLFPGQ 
PSPARCLAQ QPLSHLPLT GCLSTLFLQ AAEIFVESE LPLSWADRL 
SGCLRGPWA WLVVLLAML VEVALCTWY LVAFPPEVV TDWHMLPTE 
ALVHCRTRS WVSFGLAHA TNATLAFLC FLGTFLVRS QPGCYNRAR 
GLTFAMLAY FITWVSFVP LLANVQVVL RPAVQMGAL LLCVLGILA 
AFHLPRCYL LMRQPGLN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9NOXCSensoryTaste1TAS1R2Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOX (No Gprot) CSensoryTaste1TAS1R2Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOYCSensoryTaste1TAS1R2Homo sapiens---3.72025-04-09doi.org/10.1016/j.cell.2025.04.021
9NORCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.42025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOSCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.52025-04-09doi.org/10.1016/j.cell.2025.04.021
9NOTCSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.82025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--chim(Gs-CtGt3)/β1/γ232025-04-09doi.org/10.1016/j.cell.2025.04.021
9O38 (No Gprot) CSensoryTaste1TAS1R2; TAS1R3Homo sapiens--32025-04-09doi.org/10.1016/j.cell.2025.04.021
9OQ0CSensoryTaste1TAS1R2; TAS1R3Homo sapiens; mus musculus---3.672025-08-27To be published
9UT8CSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.412025-07-16doi.org/10.1038/s41586-025-09302-6
9UTACSensoryTaste1TAS1R2; TAS1R3Homo sapiens---3.772025-07-16doi.org/10.1038/s41586-025-09302-6
9UTBCSensoryTaste1TAS1R2; TAS1R3Homo sapiensSucralose--3.592025-07-16doi.org/10.1038/s41586-025-09302-6




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