psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G37	R:R:P38	4.06	No	No	0	2	2
2	R:R:A99	R:R:L47	4.73	No	No	0	7	8
3	R:R:L47	R:R:W346	7.97	No	Yes	0	8	6
4	R:R:I51	R:R:M95	4.37	No	Yes	0	7	8
5	R:R:I51	R:R:P96	5.08	No	No	0	7	9
6	R:R:M95	R:R:T54	6.02	Yes	No	0	8	8
7	R:R:S353	R:R:T54	6.4	No	No	0	7	8
8	R:R:L55	R:R:L92	4.15	No	No	0	6	5
9	R:R:G57	R:R:P356	4.06	No	No	0	9	9
10	R:R:A84	R:R:N58	4.69	No	No	0	9	9
11	R:R:D87	R:R:N58	6.73	Yes	No	0	9	9
12	R:R:N58	R:R:P356	13.03	No	No	0	9	9
13	R:R:A84	R:R:V61	5.09	No	No	0	9	9
14	R:R:I65	R:R:R72	5.01	No	No	0	7	8
15	R:R:I65	R:R:V81	7.68	No	No	0	7	6
16	R:R:L372	R:R:R67	14.58	No	No	0	5	5
17	R:R:H70	R:R:S68	4.18	No	Yes	3	5	6
18	R:R:L71	R:R:S68	7.51	Yes	Yes	3	8	6
19	R:R:S68	R:R:V368	6.46	Yes	No	3	6	7
20	R:R:R69	R:R:R72	5.33	No	No	0	7	8
21	R:R:H70	R:R:L71	7.71	No	Yes	3	5	8
22	R:R:L71	R:R:N77	4.12	Yes	Yes	0	8	9
23	R:R:D364	R:R:L71	4.07	No	Yes	0	7	8
24	R:R:L71	R:R:V368	5.96	Yes	No	3	8	7
25	R:R:N74	R:R:N77	5.45	No	Yes	0	8	9
26	R:R:M152	R:R:M75	4.33	No	No	0	7	7
27	R:R:M75	R:R:Q154	8.16	No	No	0	7	4
28	R:R:F365	R:R:N77	7.25	No	Yes	0	9	9
29	R:R:A157	R:R:V78	5.09	No	No	0	7	4
30	R:R:F79	R:R:V133	5.24	Yes	No	0	8	7
31	R:R:F79	R:R:I134	3.77	Yes	No	0	8	9
32	R:R:D137	R:R:F79	11.94	No	Yes	0	9	8
33	R:R:F79	R:R:M160	6.22	Yes	No	0	8	6
34	R:R:F365	R:R:I80	3.77	No	No	0	9	8
35	R:R:N130	R:R:S82	4.47	No	No	0	8	9
36	R:R:S82	R:R:V161	8.08	No	No	0	9	7
37	R:R:D87	R:R:L83	5.43	Yes	Yes	2	9	9
38	R:R:L83	R:R:N130	4.12	Yes	No	0	9	8
39	R:R:L131	R:R:L83	5.54	No	Yes	2	8	9
40	R:R:L83	R:R:N355	8.24	Yes	Yes	2	9	9
41	R:R:F89	R:R:V85	5.24	No	No	0	7	6
42	R:R:S127	R:R:S86	4.89	No	No	0	9	8
43	R:R:S86	R:R:W165	4.94	No	Yes	0	8	9
44	R:R:D87	R:R:S127	7.36	Yes	No	0	9	9
45	R:R:D87	R:R:S352	10.31	Yes	No	0	9	9
46	R:R:D87	R:R:N355	10.77	Yes	Yes	2	9	9
47	R:R:L88	R:R:L92	4.15	No	No	0	8	5
48	R:R:F89	R:R:W165	5.01	No	Yes	0	7	9
49	R:R:C123	R:R:V90	5.12	No	No	0	8	8
50	R:R:V90	R:R:W349	4.9	No	Yes	0	8	8
51	R:R:S352	R:R:V90	6.46	No	No	0	9	8
52	R:R:F119	R:R:L93	18.27	No	No	0	5	6
53	R:R:V94	R:R:W116	4.9	No	Yes	1	7	7
54	R:R:D120	R:R:V94	7.3	Yes	No	1	8	7
55	R:R:V94	R:R:W349	4.9	No	Yes	1	7	8
56	R:R:M95	R:R:W346	5.82	Yes	Yes	1	8	6
57	R:R:M95	R:R:W349	6.98	Yes	Yes	1	8	8
58	R:R:F109	R:R:W97	7.02	Yes	No	1	7	6
59	R:R:F112	R:R:W97	9.02	Yes	No	1	6	6
60	R:R:W116	R:R:W97	4.69	Yes	No	1	7	6
61	R:R:E102	R:R:K98	10.8	No	Yes	1	6	7
62	R:R:K98	R:R:W116	4.64	Yes	Yes	1	7	7
63	R:R:D342	R:R:K98	6.91	No	Yes	1	5	7
64	R:R:K98	R:R:W346	4.64	Yes	Yes	1	7	6
65	R:R:K98	R:R:W349	4.64	Yes	Yes	1	7	8
66	R:R:F109	R:R:V100	3.93	Yes	No	0	7	5
67	R:R:D342	R:R:E102	7.8	No	No	1	5	6
68	R:R:P108	R:R:Y106	6.95	No	No	0	4	5
69	R:R:F109	R:R:W107	11.02	Yes	Yes	1	7	8
70	R:R:C113	R:R:W107	5.22	No	Yes	1	9	8
71	R:R:W107	R:R:W116	7.5	Yes	Yes	1	8	7
72	R:R:C217	R:R:W107	11.75	No	Yes	1	9	8
73	R:R:F109	R:R:P108	15.89	Yes	No	0	7	4
74	R:R:F109	R:R:F112	4.29	Yes	Yes	1	7	6
75	R:R:F112	R:R:V115	5.24	Yes	No	1	6	4
76	R:R:F112	R:R:W116	9.02	Yes	Yes	1	6	7
77	R:R:F112	R:R:F119	4.29	Yes	No	1	6	5
78	R:R:C113	R:R:C217	7.28	No	No	1	9	9
79	R:R:D114	R:R:R182	5.96	No	Yes	0	7	5
80	R:R:F119	R:R:V115	6.55	No	No	1	5	4
81	R:R:A118	R:R:F173	6.93	No	No	0	7	6
82	R:R:A118	R:R:V176	5.09	No	No	0	7	6
83	R:R:D120	R:R:S124	4.42	Yes	No	1	8	7
84	R:R:D120	R:R:W349	10.05	Yes	Yes	1	8	8
85	L:L:?1	R:R:D120	11.47	Yes	Yes	1	0	8
86	R:R:I121	R:R:S172	6.19	No	No	0	7	8
87	R:R:I121	R:R:Y225	4.84	No	Yes	0	7	8
88	L:L:?1	R:R:I121	9.28	Yes	No	0	0	7
89	R:R:I169	R:R:M122	5.83	No	No	0	3	6
90	L:L:?1	R:R:S124	4.88	Yes	No	1	0	7
91	R:R:I171	R:R:T125	4.56	No	No	0	6	7
92	R:R:S233	R:R:T125	9.59	No	No	0	7	7
93	R:R:A126	R:R:W165	7.78	No	Yes	0	8	9
94	R:R:F305	R:R:I128	3.77	Yes	No	1	9	8
95	R:R:I128	R:R:W309	10.57	No	Yes	1	8	8
96	R:R:L129	R:R:L167	4.15	No	No	0	7	4
97	R:R:N130	R:R:W165	4.52	No	Yes	0	8	9
98	R:R:L131	R:R:N355	10.98	No	Yes	2	8	9
99	R:R:L131	R:R:Y359	4.69	No	Yes	2	8	9
100	R:R:C132	R:R:P237	3.77	No	Yes	0	7	9
101	R:R:C132	R:R:I240	4.91	No	No	0	7	6
102	R:R:I134	R:R:R138	5.01	No	No	2	9	9
103	R:R:I134	R:R:Y359	6.04	No	Yes	2	9	9
104	R:R:M241	R:R:S135	7.67	No	No	0	8	9
105	R:R:S135	R:R:T244	4.8	No	No	0	9	6
106	R:R:S135	R:R:Y245	11.45	No	Yes	0	9	9
107	R:R:D137	R:R:Y148	5.75	No	Yes	0	9	6
108	R:R:R138	R:R:Y245	5.14	No	Yes	0	9	9
109	R:R:R138	R:R:Y359	6.17	No	Yes	2	9	9
110	R:R:S143	R:R:Y139	13.99	No	Yes	0	7	8
111	R:R:T244	R:R:Y139	6.24	No	Yes	0	6	8
112	R:R:R247	R:R:Y139	12.35	No	Yes	0	6	8
113	R:R:W140	R:R:Y148	9.65	No	Yes	0	4	6
114	R:R:A141	R:R:Y148	9.34	No	Yes	0	8	6
115	R:R:I142	R:R:I248	4.42	No	No	0	9	9
116	R:R:I142	R:R:I251	4.42	No	No	0	9	6
117	R:R:R144	R:R:S143	5.27	No	No	0	6	7
118	R:R:R147	R:R:R150	5.33	No	No	0	6	5
119	R:R:M152	R:R:Y148	16.76	No	Yes	0	7	6
120	R:R:I232	R:R:L167	4.28	No	No	0	4	4
121	R:R:I171	R:R:S229	4.64	No	No	0	6	6
122	R:R:F173	R:R:S172	5.28	No	No	0	6	8
123	R:R:P175	R:R:W180	4.05	No	No	0	6	8
124	R:R:P175	R:R:Y225	8.34	No	Yes	0	6	8
125	R:R:H181	R:R:V176	15.22	Yes	No	0	6	6
126	R:R:L178	R:R:W180	15.94	No	No	0	5	8
127	R:R:N179	R:R:R182	8.44	No	Yes	0	6	5
128	R:R:H181	R:R:R182	16.93	Yes	Yes	0	6	5
129	R:R:H181	R:R:Y225	4.36	Yes	Yes	0	6	8
130	R:R:D218	R:R:R182	4.76	No	Yes	0	5	5
131	R:R:D218	R:R:S220	7.36	No	No	0	5	3
132	L:L:?1	R:R:S219	8.78	Yes	No	0	0	4
133	R:R:L221	R:R:Y225	4.69	No	Yes	0	5	8
134	R:R:N222	R:R:T224	5.85	No	No	0	6	4
135	R:R:F321	R:R:R223	10.69	No	No	0	5	5
136	R:R:S229	R:R:Y225	12.72	No	Yes	0	6	8
137	L:L:?1	R:R:S229	6.83	Yes	No	0	0	6
138	R:R:F313	R:R:S230	5.28	Yes	No	0	7	7
139	R:R:N316	R:R:S230	5.96	No	No	0	7	7
140	L:L:?1	R:R:S233	3.9	Yes	No	0	0	7
141	R:R:F234	R:R:Y235	9.28	Yes	No	0	8	5
142	R:R:F234	R:R:V238	7.87	Yes	No	1	8	7
143	R:R:F234	R:R:F305	4.29	Yes	Yes	1	8	9
144	R:R:F234	R:R:W309	4.01	Yes	Yes	1	8	8
145	R:R:F234	R:R:F313	20.36	Yes	Yes	1	8	7
146	R:R:F305	R:R:V238	3.93	Yes	No	1	9	7
147	R:R:M241	R:R:M302	4.33	No	No	0	8	8
148	R:R:F305	R:R:M241	8.71	Yes	No	0	9	8
149	R:R:R247	R:R:V243	3.92	No	No	0	6	4
150	R:R:L298	R:R:Y245	4.69	No	Yes	0	8	9
151	R:R:I301	R:R:Y245	4.84	No	Yes	0	8	9
152	R:R:Q253	R:R:Y249	15.78	No	No	0	6	6
153	R:R:L295	R:R:Y249	7.03	No	No	0	7	6
154	R:R:Q253	R:R:R257	5.84	No	No	0	6	7
155	R:R:E291	R:R:Q253	7.65	No	No	0	8	6
156	R:R:R258	R:R:V254	3.92	No	No	0	5	4
157	R:R:I301	R:R:Y359	4.84	No	Yes	0	8	9
158	R:R:L354	R:R:V304	4.47	No	No	0	6	7
159	R:R:I358	R:R:V304	4.61	No	No	0	8	7
160	R:R:F305	R:R:W309	5.01	Yes	Yes	1	9	8
161	R:R:C308	R:R:N351	7.87	No	No	0	8	9
162	R:R:F313	R:R:W309	5.01	Yes	Yes	1	7	8
163	R:R:G348	R:R:W309	8.44	No	Yes	0	8	8
164	R:R:N351	R:R:W309	9.04	No	Yes	0	9	8
165	R:R:I314	R:R:L310	7.14	No	No	0	6	7
166	R:R:F344	R:R:P311	5.78	No	No	0	6	9
167	R:R:F312	R:R:F313	10.72	Yes	Yes	1	7	7
168	R:R:F312	R:R:N316	12.08	Yes	No	0	7	7
169	R:R:F312	R:R:F341	5.36	Yes	Yes	1	7	4
170	L:L:?1	R:R:F312	11.87	Yes	Yes	1	0	7
171	L:L:?1	R:R:F313	7.12	Yes	Yes	1	0	7
172	R:R:F344	R:R:L315	6.09	No	No	0	6	5
173	R:R:F341	R:R:V319	3.93	Yes	No	0	4	4
174	R:R:C322	R:R:C335	7.28	No	No	0	2	4
175	R:R:T340	R:R:V336	4.76	No	No	0	4	3
176	L:L:?1	R:R:F341	4.75	Yes	Yes	1	0	4
177	R:R:V345	R:R:W349	7.36	No	Yes	1	6	8
178	L:L:?1	R:R:V345	11.62	Yes	No	1	0	6
179	R:R:W346	R:R:W349	11.25	Yes	Yes	1	6	8
180	L:L:?1	R:R:W349	7.4	Yes	Yes	1	0	8
181	R:R:N351	R:R:N355	8.17	No	Yes	0	9	9
182	R:R:I358	R:R:Y359	7.25	No	Yes	0	8	9
183	R:R:F361	R:R:Q366	11.71	No	No	0	7	9
184	R:R:F365	R:R:F369	6.43	No	No	0	9	8
185	R:R:K367	R:R:Q371	4.07	No	No	0	5	5
186	R:R:A226	R:R:P320	3.74	No	No	0	6	5
187	R:R:F173	R:R:M122	3.73	No	No	0	6	6
188	R:R:K151	R:R:R147	3.71	No	No	0	5	6
189	R:R:F234	R:R:L310	3.65	Yes	No	0	8	7
190	R:R:F341	R:R:L315	3.65	Yes	No	0	4	5
191	R:R:I248	R:R:Y139	3.63	No	Yes	0	9	8
192	R:R:P320	R:R:V319	3.53	No	No	0	5	4
193	R:R:L231	R:R:Y235	3.52	No	No	0	5	5
194	R:R:N222	R:R:Y225	3.49	No	Yes	0	6	8
195	R:R:C317	R:R:S230	3.44	No	No	0	6	7
196	R:R:A126	R:R:S168	3.42	No	No	0	8	8
197	R:R:A64	R:R:V368	3.39	No	No	0	7	7
198	R:R:I128	R:R:P237	3.39	No	Yes	0	8	9
199	R:R:I174	R:R:P175	3.39	No	No	0	7	6
200	R:R:I236	R:R:P237	3.39	No	Yes	0	6	9
201	R:R:A252	R:R:V294	3.39	No	No	0	8	8
202	R:R:A91	R:R:T54	3.36	No	No	0	7	8
203	R:R:G37	R:R:Q40	3.29	No	No	0	2	4
204	R:R:L129	R:R:P237	3.28	No	Yes	0	7	9
205	R:R:V319	R:R:V336	3.21	No	No	0	4	3
206	R:R:S337	R:R:T340	3.2	No	No	0	5	4
207	R:R:I242	R:R:V238	3.07	No	No	0	5	7
208	R:R:I358	R:R:V300	3.07	No	No	0	8	7
209	R:R:I52	R:R:T48	3.04	No	No	0	5	3
210	R:R:L50	R:R:S353	3	No	No	0	7	7
211	R:R:L298	R:R:V294	2.98	No	No	0	8	8
212	R:R:L310	R:R:V306	2.98	No	No	0	7	6
213	R:R:L170	R:R:T166	2.95	No	No	0	4	5
214	R:R:N77	R:R:T76	2.92	Yes	No	0	9	8
215	R:R:I314	R:R:M318	2.92	No	No	0	6	5
216	R:R:I256	R:R:K290	2.91	No	No	0	5	6
217	R:R:D137	R:R:T76	2.89	No	No	0	9	8
218	R:R:M152	R:R:M156	2.89	No	No	0	7	7
219	R:R:I52	R:R:L56	2.85	No	No	0	5	4
220	R:R:G110	R:R:W107	2.81	No	Yes	0	8	8
221	R:R:H181	R:R:V117	2.77	Yes	No	0	6	5
222	R:R:E291	R:R:I256	2.73	No	No	0	8	5
223	R:R:D183	R:R:N222	2.69	No	No	0	3	6
224	R:R:A104	R:R:Y106	2.67	No	No	0	5	5
225	R:R:R67	R:R:S68	2.64	No	Yes	0	5	6
226	R:R:R264	R:R:S261	2.64	No	No	0	3	5
227	R:R:F344	R:R:V343	2.62	No	No	0	6	5
228	R:R:F347	R:R:V343	2.62	No	No	0	7	5
229	R:R:A101	R:R:W107	2.59	No	Yes	0	6	8
230	R:R:V294	R:R:Y249	2.52	No	No	0	8	6
231	R:R:F369	R:R:L60	2.44	No	No	0	8	6
232	R:R:Q255	R:R:R258	2.34	No	No	0	7	5
233	R:R:G162	R:R:V161	1.84	No	No	0	4	7
234	R:R:C45	R:R:V41	1.71	No	No	0	3	4
235	R:R:G57	R:R:L56	1.71	No	No	0	9	4
236	R:R:C62	R:R:V81	1.71	No	No	0	7	6
237	R:R:C62	R:R:V85	1.71	No	No	0	7	6
238	R:R:C335	R:R:V336	1.71	No	No	0	4	3
239	R:R:A44	R:R:V103	1.7	No	No	0	5	6
240	R:R:A360	R:R:V61	1.7	No	No	0	8	9
241	R:R:A164	R:R:V133	1.7	No	No	0	7	7
242	R:R:S82	R:R:V78	1.62	No	No	0	9	4
243	R:R:T43	R:R:V103	1.59	No	No	0	5	6
244	R:R:T244	R:R:V136	1.59	No	No	0	6	5
245	R:R:A91	R:R:L55	1.58	No	No	0	7	6
246	R:R:A63	R:R:L372	1.58	No	No	0	4	5
247	R:R:I242	R:R:T246	1.52	No	No	0	5	3
248	R:R:I301	R:R:T297	1.52	No	No	0	8	9
249	R:R:M156	R:R:T153	1.51	No	No	0	7	7
250	R:R:K289	R:R:T292	1.5	No	No	0	6	6
251	R:R:L46	R:R:V42	1.49	No	No	0	5	3
252	R:R:L55	R:R:V59	1.49	No	No	0	6	4
253	R:R:L88	R:R:V59	1.49	No	No	0	8	4
254	R:R:L163	R:R:V159	1.49	No	No	0	3	4
255	R:R:P145	R:R:R144	1.44	No	No	0	9	6
256	R:R:Q40	R:R:V103	1.43	No	No	0	4	6
257	R:R:I174	R:R:L170	1.43	No	No	0	7	4
258	R:R:Q177	R:R:V176	1.43	No	No	0	5	6
259	R:R:L46	R:R:L47	1.38	No	No	0	5	8
260	R:R:E263	R:R:I259	1.37	No	No	0	5	6
261	R:R:D364	R:R:N362	1.35	No	No	0	7	9
262	R:R:R223	R:R:S323	1.32	No	No	0	5	3
263	R:R:R264	R:R:S260	1.32	No	No	0	3	4
264	R:R:R155	R:R:T153	1.29	No	No	0	4	7
265	R:R:F321	R:R:I227	1.26	No	No	0	5	6
266	R:R:K151	R:R:W140	1.16	No	No	0	5	4
267	R:R:R247	R:R:R250	1.07	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S68	5.1975	4	3	6
2	R:R:L71	5.874	5	3	8
3	R:R:N77	4.935	4	0	9
4	R:R:F79	6.7925	4	0	8
5	R:R:L83	5.8325	4	2	9
6	R:R:D87	8.12	5	2	9
7	R:R:M95	5.7975	4	1	8
8	R:R:K98	6.326	5	1	7
9	R:R:W107	6.815	6	1	8
10	R:R:F109	8.43	5	1	7
11	R:R:F112	6.372	5	1	6
12	R:R:W116	6.15	5	1	7
13	R:R:D120	8.31	4	1	8
14	R:R:Y139	9.0525	4	0	8
15	R:R:Y148	10.375	4	0	6
16	R:R:W165	5.5625	4	0	9
17	R:R:H181	9.82	4	0	6
18	R:R:R182	9.0225	4	0	5
19	R:R:Y225	6.40667	6	0	8
20	R:R:F234	8.24333	6	1	8
21	R:R:P237	3.4575	4	0	9
22	R:R:Y245	6.53	4	0	9
23	R:R:F305	5.142	5	1	9
24	R:R:W309	7.01333	6	1	8
25	R:R:F312	10.0075	4	1	7
26	R:R:F313	9.698	5	1	7
27	R:R:F341	4.4225	4	1	4
28	R:R:W346	7.42	4	1	6
29	R:R:W349	7.185	8	1	8
30	R:R:N355	9.54	4	2	9
31	R:R:Y359	5.798	5	2	9
32	L:L:?1	7.99091	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M95	R:R:T54	18.5961	6.02	Yes	No	0	8	8
2	R:R:A91	R:R:T54	12.4945	3.36	No	No	0	7	8
3	R:R:A91	R:R:L55	10.4387	1.58	No	No	0	7	6
4	R:R:V90	R:R:W349	71.1906	4.9	No	Yes	0	8	8
5	R:R:S352	R:R:V90	70.9048	6.46	No	No	0	9	8
6	R:R:D87	R:R:S352	71.4765	10.31	Yes	No	0	9	9
7	R:R:D87	R:R:N58	20.3276	6.73	Yes	No	0	9	9
8	R:R:N58	R:R:P356	11.4006	13.03	No	No	0	9	9
9	R:R:D87	R:R:L83	40.3199	5.43	Yes	Yes	2	9	9
10	R:R:L83	R:R:N130	32.6077	4.12	Yes	No	0	9	8
11	R:R:N130	R:R:W165	20.8938	4.52	No	Yes	0	8	9
12	R:R:F89	R:R:W165	20.5145	5.01	No	Yes	0	7	9
13	R:R:F89	R:R:V85	17.6396	5.24	No	No	0	7	6
14	R:R:C62	R:R:V85	14.7263	1.71	No	No	0	7	6
15	R:R:C62	R:R:V81	11.8019	1.71	No	No	0	7	6
16	R:R:D87	R:R:S127	12.9672	7.36	Yes	No	0	9	9
17	R:R:S127	R:R:S86	10.8729	4.89	No	No	0	9	8
18	R:R:L131	R:R:L83	34.779	5.54	No	Yes	2	8	9
19	R:R:L131	R:R:Y359	86.0983	4.69	No	Yes	2	8	9
20	R:R:I134	R:R:Y359	60.9828	6.04	No	Yes	2	9	9
21	R:R:F79	R:R:I134	68.0244	3.77	Yes	No	0	8	9
22	R:R:D137	R:R:F79	60.6805	11.94	No	Yes	0	9	8
23	R:R:D137	R:R:T76	35.5981	2.89	No	No	0	9	8
24	R:R:N77	R:R:T76	33.5917	2.92	Yes	No	0	9	8
25	R:R:L71	R:R:N77	21.3226	4.12	Yes	Yes	0	8	9
26	R:R:D87	R:R:N355	29.524	10.77	Yes	Yes	2	9	9
27	R:R:L131	R:R:N355	52.5396	10.98	No	Yes	2	8	9
28	R:R:D137	R:R:Y148	25.4562	5.75	No	Yes	0	9	6
29	R:R:M152	R:R:Y148	12.9233	16.76	No	Yes	0	7	6
30	R:R:N130	R:R:S82	10.4387	4.47	No	No	0	8	9
31	R:R:K98	R:R:W116	44.5141	4.64	Yes	Yes	1	7	7
32	R:R:F112	R:R:W116	37.456	9.02	Yes	Yes	1	6	7
33	R:R:V94	R:R:W349	43.2333	4.9	No	Yes	1	7	8
34	R:R:W116	R:R:W97	24.923	4.69	Yes	No	1	7	6
35	R:R:F109	R:R:W97	20.8004	7.02	Yes	No	1	7	6
36	R:R:W107	R:R:W116	41.6337	7.5	Yes	Yes	1	8	7
37	R:R:F109	R:R:W107	21.0202	11.02	Yes	Yes	1	7	8
38	R:R:F109	R:R:F112	20.9653	4.29	Yes	Yes	1	7	6
39	R:R:F109	R:R:V100	12.522	3.93	Yes	No	0	7	5
40	R:R:F109	R:R:P108	37.544	15.89	Yes	No	0	7	4
41	R:R:P108	R:R:Y106	25.0385	6.95	No	No	0	4	5
42	L:L:?1	R:R:W349	75.7586	7.4	Yes	Yes	1	0	8
43	L:L:?1	R:R:I121	44.3547	9.28	Yes	No	0	0	7
44	R:R:I121	R:R:Y225	34.4987	4.84	No	Yes	0	7	8
45	R:R:H181	R:R:Y225	31.4259	4.36	Yes	Yes	0	6	8
46	R:R:H181	R:R:R182	17.6781	16.93	Yes	Yes	0	6	5
47	L:L:?1	R:R:S229	37.6429	6.83	Yes	No	0	0	6
48	R:R:S229	R:R:Y225	34.5536	12.72	No	Yes	0	6	8
49	L:L:?1	R:R:F313	100	7.12	Yes	Yes	1	0	7
50	R:R:F234	R:R:F313	40.4464	20.36	Yes	Yes	1	8	7
51	R:R:F234	R:R:F305	32.6462	4.29	Yes	Yes	1	8	9
52	R:R:F313	R:R:W309	72.9222	5.01	Yes	Yes	1	7	8
53	R:R:F305	R:R:W309	32.6957	5.01	Yes	Yes	1	9	8
54	R:R:I128	R:R:W309	12.0273	10.57	No	Yes	1	8	8
55	R:R:I128	R:R:P237	13.44	3.39	No	Yes	0	8	9
56	R:R:F305	R:R:M241	66.4303	8.71	Yes	No	0	9	8
57	R:R:M241	R:R:S135	62.4175	7.67	No	No	0	8	9
58	R:R:S135	R:R:T244	37.9233	4.8	No	No	0	9	6
59	R:R:S135	R:R:Y245	42.9804	11.45	No	Yes	0	9	9
60	R:R:T244	R:R:Y139	31.7117	6.24	No	Yes	0	6	8
61	R:R:P175	R:R:Y225	21.3336	8.34	No	Yes	0	6	8
62	R:R:N222	R:R:Y225	10.7135	3.49	No	Yes	0	6	8
63	R:R:L298	R:R:Y245	31.3819	4.69	No	Yes	0	8	9
64	R:R:I301	R:R:Y359	10.9554	4.84	No	Yes	0	8	9
65	R:R:L298	R:R:V294	28.2927	2.98	No	No	0	8	8
66	R:R:V294	R:R:Y249	22.0811	2.52	No	No	0	8	6
67	R:R:Q253	R:R:Y249	15.8256	15.78	No	No	0	6	6
68	R:R:N351	R:R:W309	42.6616	9.04	No	Yes	0	9	8
69	L:L:?1	R:R:F341	26.5446	4.75	Yes	Yes	1	0	4
70	R:R:F341	R:R:L315	13.8742	3.65	Yes	No	0	4	5
71	R:R:F344	R:R:L315	11.1203	6.09	No	No	0	6	5
72	R:R:F341	R:R:V319	22.0701	3.93	Yes	No	0	4	4
73	R:R:V319	R:R:V336	13.8742	3.21	No	No	0	4	3
74	R:R:I174	R:R:P175	10.7135	3.39	No	No	0	7	6
75	R:R:A104	R:R:Y106	12.522	2.67	No	No	0	5	5
76	R:R:M95	R:R:W349	22.279	6.98	Yes	Yes	1	8	8
77	R:R:V94	R:R:W116	63.1102	4.9	No	Yes	1	7	7
78	R:R:K98	R:R:W349	46.383	4.64	Yes	Yes	1	7	8
79	R:R:N351	R:R:N355	41.1115	8.17	No	Yes	0	9	9
80	R:R:R138	R:R:Y245	17.1669	5.14	No	Yes	0	9	9
81	R:R:F312	R:R:F313	13.0442	10.72	Yes	Yes	1	7	7
82	R:R:L83	R:R:N355	10.785	8.24	Yes	Yes	2	9	9
83	R:R:F312	R:R:F341	11.615	5.36	Yes	Yes	1	7	4
84	L:L:?1	R:R:D120	22.8727	11.47	Yes	Yes	1	0	8
85	R:R:D120	R:R:V94	22.1086	7.3	Yes	No	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V90	R:R:W349	4.9	0	No	Yes	8	8	2	1
R:R:D120	R:R:V94	7.3	1	Yes	No	8	7	1	2
R:R:V94	R:R:W349	4.9	1	No	Yes	7	8	2	1
R:R:M95	R:R:W346	5.82	1	Yes	Yes	8	6	2	2
R:R:M95	R:R:W349	6.98	1	Yes	Yes	8	8	2	1
R:R:K98	R:R:W346	4.64	1	Yes	Yes	7	6	2	2
R:R:K98	R:R:W349	4.64	1	Yes	Yes	7	8	2	1
R:R:D120	R:R:S124	4.42	1	Yes	No	8	7	1	1
R:R:D120	R:R:W349	10.05	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D120	11.47	1	Yes	Yes	0	8	0	1
R:R:I121	R:R:S172	6.19	0	No	No	7	8	1	2
R:R:I121	R:R:Y225	4.84	0	No	Yes	7	8	1	2
L:L:?1	R:R:I121	9.28	1	Yes	No	0	7	0	1
L:L:?1	R:R:S124	4.88	1	Yes	No	0	7	0	1
R:R:I171	R:R:T125	4.56	0	No	No	6	7	2	2
R:R:S233	R:R:T125	9.59	0	No	No	7	7	1	2
R:R:I171	R:R:S229	4.64	0	No	No	6	6	2	1
L:L:?1	R:R:S219	8.78	1	Yes	No	0	4	0	1
R:R:S229	R:R:Y225	12.72	0	No	Yes	6	8	1	2
L:L:?1	R:R:S229	6.83	1	Yes	No	0	6	0	1
R:R:F313	R:R:S230	5.28	1	Yes	No	7	7	1	2
R:R:N316	R:R:S230	5.96	0	No	No	7	7	2	2
L:L:?1	R:R:S233	3.9	1	Yes	No	0	7	0	1
R:R:F234	R:R:W309	4.01	1	Yes	Yes	8	8	2	2
R:R:F234	R:R:F313	20.36	1	Yes	Yes	8	7	2	1
R:R:F313	R:R:W309	5.01	1	Yes	Yes	7	8	1	2
R:R:F312	R:R:F313	10.72	1	Yes	Yes	7	7	1	1
R:R:F312	R:R:N316	12.08	1	Yes	No	7	7	1	2
R:R:F312	R:R:F341	5.36	1	Yes	Yes	7	4	1	1
L:L:?1	R:R:F312	11.87	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F313	7.12	1	Yes	Yes	0	7	0	1
R:R:F341	R:R:V319	3.93	1	Yes	No	4	4	1	2
L:L:?1	R:R:F341	4.75	1	Yes	Yes	0	4	0	1
R:R:V345	R:R:W349	7.36	1	No	Yes	6	8	1	1
L:L:?1	R:R:V345	11.62	1	Yes	No	0	6	0	1
R:R:W346	R:R:W349	11.25	1	Yes	Yes	6	8	2	1
L:L:?1	R:R:W349	7.4	1	Yes	Yes	0	8	0	1
R:R:F341	R:R:L315	3.65	1	Yes	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IRV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	245
Number of Links	267
Number of Hubs	32
Number of Links mediated by Hubs	126
Number of Communities	3
Number of Nodes involved in Communities	39
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	55385
Length Of Smallest Path	3
Average Path Length	12.0209
Length of Longest Path	24
Minimum Path Strength	1.4
Average Path Strength	6.68159
Maximum Path Strength	16.075
Minimum Path Correlation	0.7
Average Path Correlation	0.941797
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	7.14286
Average % Of Corr. Nodes	60.9292
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0115
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • dopamine neurotransmitter receptor activity, coupled via Gs • catecholamine binding • dopamine binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • reactive oxygen species metabolic process • behavior • learning • learning or memory • nonassociative learning • sensitization • cognition • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of female receptivity • reproductive process • multicellular organismal reproductive process • female mating behavior • reproductive behavior • regulation of biological quality • mating behavior • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • circulatory system process • endocrine process • regulation of systemic arterial blood pressure by vasopressin • blood circulation • regulation of tube diameter • regulation of tube size • positive regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • vascular process in circulatory system • positive regulation of blood pressure by epinephrine-norepinephrine • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • transmission of nerve impulse • trans-synaptic signaling • chemical synaptic transmission • anterograde trans-synaptic signaling • synaptic transmission, dopaminergic • wound healing • response to stress • response to wounding • activation of adenylate cyclase activity • associative learning • response to amine • response to amphetamine • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • regulation of synaptic plasticity • regulation of trans-synaptic signaling • long-term synaptic depression • response to cocaine • response to alkaloid • negative regulation of blood pressure • phospholipase C-activating dopamine receptor signaling pathway • periplasmic space • ciliary membrane • plasma membrane region • cell projection membrane • brush border membrane • cluster of actin-based cell projections • brush border • apical part of cell • apical plasma membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	R5F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	R5F
Name	Rotigotine
Synonyms	(6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Identifier
Formula	C19 H25 N O S
Molecular Weight	315.473
SMILES
PubChem	59227
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21918
Sequence	>8IRV_nogp_Chain_R G P S Q V V T A C L L T L L I I W T L L G N V L V C A A I V R S R H L R A N M T N V F I V S L A V S D L F V A L L V M P W K A V A E V A G Y W P F G A F C D V W V A F D I M C S T A S I L N L C V I S V D R Y W A I S R P F R Y K R K M T Q R M A L V M V G L A W T L S I L I S F I P V Q L N W H R D E N C D S S L N R T Y A I S S S L I S F Y I P V A I M I V T Y T R I Y R I A Q V Q I R R I S S L E R A A E H A Q S K K E T K V L K T L S V I M G V F V C C W L P F F I L N C M V P F C S C V S E T T F D V F V W F G W A N S S L N P V I Y A F N A D F Q K V F A Q L L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5D5A	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	2.48	2016-01-13	doi.org/10.1107/S2059798315021683
	5D5B	A	Amine	Adrenergic	β₂	Homo sapiens	S-Carazolol	-	-	3.8	2016-01-13	doi.org/10.1107/S2059798315021683
	7DD5	C	Ion	Calcium Sensing	CaS	Gallus gallus	Ca	Ca; Ca; Tryptophan; NPS-2143	-	3.2	2021-06-16	doi.org/10.1126/sciadv.abg1483
	8IRV	A	Amine	Dopamine	D₅	Homo sapiens	Rotigotine	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRV (No Gprot)	A	Amine	Dopamine	D₅	Homo sapiens	Rotigotine	-		3.1	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD5	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu4	Homo sapiens	Glutamate	JNJ-40411813; ADX88178	Gi1/β1/γ2	3.6	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8JD5 (No Gprot)	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu4	Homo sapiens	Glutamate	JNJ-40411813; ADX88178		3.6	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	9IYB	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q	Gi1/β1/γ2	2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	9IYB (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Prostaglandin	A1D5Q		2.82	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q	Gi1/β1/γ2	2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXU (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	-	A1D5Q		2.54	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q	Gi1/β1/γ2	2.33	2024-12-04	doi.org/10.1073/pnas.2403304121
	8XXV (No Gprot)	A	Lipid	Prostanoid	DP₂	Homo sapiens	Indomethacin	A1D5Q		2.33	2024-12-04	doi.org/10.1073/pnas.2403304121

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