psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:R1	4.32	Yes	No	0	0	0
2	L:L:P2	L:L:Q6	4.74	Yes	No	2	0	0
3	L:L:F8	L:L:P2	7.22	Yes	Yes	2	0	0
4	L:L:P2	R:R:M181	6.71	Yes	No	2	0	4
5	L:L:K3	L:L:P4	5.02	No	No	0	0	0
6	L:L:P4	L:L:Q5	4.74	No	No	0	0	0
7	L:L:Q5	R:R:Q24	12.8	No	No	0	0	3
8	L:L:F8	L:L:Q6	22.25	Yes	No	2	0	0
9	L:L:F7	L:L:G9	3.01	Yes	No	1	0	0
10	L:L:F7	R:R:F25	12.86	Yes	Yes	1	0	6
11	L:L:F7	R:R:N96	10.87	Yes	Yes	1	0	4
12	L:L:F7	R:R:I283	3.77	Yes	No	1	0	4
13	L:L:F7	R:R:Q284	5.86	Yes	No	1	0	4
14	L:L:F7	R:R:Y287	4.13	Yes	Yes	1	0	5
15	L:L:F8	R:R:V179	7.87	Yes	No	0	0	3
16	L:L:F8	R:R:M181	9.95	Yes	No	2	0	4
17	L:L:G9	R:R:Y287	4.35	No	Yes	1	0	5
18	L:L:L10	R:R:Y92	4.69	No	No	0	0	4
19	L:L:M11	R:R:I113	4.37	Yes	Yes	1	0	5
20	L:L:M11	R:R:Q165	8.16	Yes	No	1	0	6
21	L:L:M11	R:R:F264	3.73	Yes	Yes	1	0	7
22	L:L:M11	R:R:F268	9.95	Yes	No	1	0	6
23	R:R:F25	R:R:N23	3.62	Yes	Yes	0	6	8
24	R:R:N23	R:R:V26	5.91	Yes	No	0	8	1
25	R:R:E97	R:R:N23	5.26	No	Yes	0	4	8
26	R:R:N23	R:R:R177	13.26	Yes	Yes	0	8	2
27	R:R:F25	R:R:Q24	9.37	Yes	No	0	6	3
28	R:R:K281	R:R:Q24	6.78	No	No	0	2	3
29	R:R:F25	R:R:N96	7.25	Yes	Yes	1	6	4
30	R:R:F25	R:R:Q284	8.2	Yes	No	1	6	4
31	R:R:H95	R:R:V26	8.3	No	No	0	5	1
32	R:R:P28	R:R:Q27	3.16	No	Yes	1	2	4
33	R:R:Q27	R:R:Q31	3.84	Yes	Yes	1	4	2
34	R:R:I32	R:R:Q27	4.12	No	Yes	0	3	4
35	R:R:Q27	R:R:Q284	15.36	Yes	No	1	4	4
36	R:R:Q27	R:R:Q285	3.84	Yes	No	1	4	1
37	R:R:P28	R:R:W30	4.05	No	No	1	2	1
38	R:R:P28	R:R:Q31	7.9	No	Yes	1	2	2
39	R:R:Q31	R:R:W30	12.05	Yes	No	1	2	1
40	R:R:Q285	R:R:Q31	3.84	No	Yes	1	1	2
41	R:R:I32	R:R:V94	7.68	No	No	0	3	5
42	R:R:L288	R:R:W35	12.53	No	No	0	3	4
43	R:R:F90	R:R:Y39	11.35	No	No	0	6	7
44	R:R:L288	R:R:Y39	4.69	No	No	0	3	7
45	R:R:W292	R:R:Y39	11.58	No	No	0	5	7
46	R:R:I42	R:R:V41	3.07	No	No	0	7	5
47	R:R:I42	R:R:W292	11.74	No	No	0	7	5
48	R:R:I42	R:R:M299	2.92	No	Yes	0	7	7
49	R:R:T86	R:R:V43	3.17	No	No	0	7	6
50	R:R:M299	R:R:T45	9.03	Yes	No	0	7	4
51	R:R:S46	R:R:T298	6.4	No	No	0	8	9
52	R:R:M299	R:R:S46	6.13	Yes	No	0	7	8
53	R:R:G49	R:R:P302	4.06	No	No	0	8	9
54	R:R:E78	R:R:N50	5.26	Yes	No	0	9	9
55	R:R:F316	R:R:V52	5.24	No	No	0	6	6
56	R:R:A75	R:R:M54	3.22	No	No	0	9	7
57	R:R:F76	R:R:M54	4.98	No	No	0	6	7
58	R:R:I56	R:R:W55	3.52	Yes	Yes	0	8	4
59	R:R:A59	R:R:W55	7.78	No	Yes	0	4	4
60	R:R:G315	R:R:I56	3.53	No	Yes	0	6	8
61	R:R:F316	R:R:I56	3.77	No	Yes	0	6	8
62	R:R:I57	R:R:N68	5.66	No	No	0	7	8
63	R:R:I57	R:R:V72	6.14	No	No	0	7	6
64	R:R:A59	R:R:H60	2.93	No	No	0	4	5
65	R:R:K61	R:R:R64	4.95	No	No	0	6	6
66	R:R:M63	R:R:R311	6.2	No	Yes	0	7	6
67	R:R:T65	R:R:T67	3.14	No	No	3	7	8
68	R:R:N68	R:R:T65	2.92	No	No	3	8	7
69	R:R:V66	R:R:Y69	6.31	No	No	0	6	5
70	R:R:R141	R:R:V66	5.23	No	No	0	5	6
71	R:R:N68	R:R:T67	2.92	No	No	3	8	8
72	R:R:R141	R:R:T67	5.17	No	No	0	5	8
73	R:R:T147	R:R:Y69	4.99	No	No	0	7	5
74	R:R:A125	R:R:F70	6.93	No	Yes	0	7	7
75	R:R:D129	R:R:F70	11.94	No	Yes	0	9	7
76	R:R:F70	R:R:T147	3.89	Yes	No	0	7	7
77	R:R:F70	R:R:I151	5.02	Yes	No	0	7	8
78	R:R:L71	R:R:V126	2.98	No	No	0	8	9
79	R:R:L71	R:R:Y305	4.69	No	No	0	8	9
80	R:R:N73	R:R:S122	7.45	No	No	0	9	8
81	R:R:I151	R:R:N73	7.08	No	No	0	8	9
82	R:R:N73	R:R:W155	5.65	No	No	0	9	9
83	R:R:E78	R:R:L74	6.63	Yes	No	0	9	9
84	R:R:L74	R:R:S122	3	No	No	0	9	8
85	R:R:L74	R:R:M123	4.24	No	No	0	9	8
86	R:R:F76	R:R:S80	7.93	No	No	0	6	6
87	R:R:E78	R:R:S119	4.31	Yes	No	0	9	9
88	R:R:E78	R:R:T298	7.06	Yes	No	0	9	9
89	R:R:E78	R:R:N301	3.94	Yes	No	0	9	9
90	R:R:M81	R:R:V116	10.65	No	No	0	7	7
91	R:R:M295	R:R:M81	5.78	No	No	0	7	7
92	R:R:F111	R:R:F84	3.22	No	No	0	4	5
93	R:R:N85	R:R:N89	10.9	No	Yes	0	6	6
94	R:R:N85	R:R:P112	4.89	No	No	0	6	6
95	R:R:M295	R:R:T86	7.53	No	No	0	7	7
96	R:R:H108	R:R:V88	13.84	Yes	No	0	5	5
97	R:R:H108	R:R:N89	7.65	Yes	Yes	0	5	6
98	R:R:N89	R:R:Y287	4.65	Yes	Yes	0	6	5
99	R:R:M291	R:R:N89	4.21	No	Yes	0	5	6
100	R:R:F90	R:R:V94	7.87	No	No	0	6	5
101	R:R:T91	R:R:Y100	6.24	No	No	0	4	7
102	R:R:N96	R:R:Y92	3.49	Yes	No	0	4	4
103	R:R:W98	R:R:Y92	8.68	Yes	No	0	8	4
104	R:R:H95	R:R:V94	4.15	No	No	0	5	5
105	R:R:H95	R:R:Y99	3.27	No	No	0	5	2
106	R:R:N96	R:R:R177	3.62	Yes	Yes	0	4	2
107	R:R:E97	R:R:Y99	6.73	No	No	0	4	2
108	R:R:W98	R:R:Y100	12.54	Yes	No	0	8	7
109	R:R:C105	R:R:W98	3.92	Yes	Yes	5	9	8
110	R:R:C180	R:R:W98	16.98	No	Yes	5	9	8
111	R:R:Y100	R:R:Y104	4.96	No	No	0	7	5
112	R:R:L102	R:R:T171	4.42	No	No	0	3	5
113	R:R:H108	R:R:Y104	3.27	Yes	No	0	5	5
114	R:R:C105	R:R:S169	5.16	Yes	Yes	0	9	5
115	R:R:C105	R:R:T171	3.38	Yes	No	0	9	5
116	R:R:C105	R:R:C180	7.28	Yes	No	5	9	9
117	R:R:K106	R:R:S169	3.06	No	Yes	0	6	5
118	R:R:F107	R:R:F111	8.57	No	No	0	4	4
119	R:R:H108	R:R:P112	3.05	Yes	No	0	5	6
120	R:R:N109	R:R:S169	5.96	No	Yes	0	5	5
121	R:R:I182	R:R:N109	5.66	No	No	0	4	5
122	R:R:F110	R:R:L159	3.65	No	No	0	6	4
123	R:R:F110	R:R:F163	3.22	No	No	0	6	4
124	R:R:F111	R:R:P112	5.78	No	No	0	4	6
125	R:R:F117	R:R:I113	5.02	No	Yes	0	7	5
126	R:R:A162	R:R:I113	3.25	No	Yes	0	7	5
127	R:R:I113	R:R:Q165	5.49	Yes	No	1	5	6
128	R:R:V116	R:R:W261	3.68	No	Yes	0	7	8
129	R:R:F117	R:R:L161	7.31	No	No	0	7	5
130	R:R:F117	R:R:I204	10.05	No	No	0	7	6
131	R:R:A118	R:R:W155	7.78	No	No	0	7	9
132	R:R:I120	R:R:S119	3.1	No	No	0	7	9
133	R:R:I120	R:R:P208	3.39	No	No	0	7	9
134	R:R:T124	R:R:V211	3.17	No	No	0	7	6
135	R:R:I212	R:R:T124	3.04	No	No	0	8	7
136	R:R:R130	R:R:V126	6.54	No	No	0	9	9
137	R:R:A127	R:R:I212	3.25	No	No	6	9	8
138	R:R:A127	R:R:Y216	5.34	No	Yes	6	9	9
139	R:R:F128	R:R:M132	6.22	No	No	0	5	5
140	R:R:D129	R:R:R141	8.34	No	No	0	9	5
141	R:R:R130	R:R:Y216	4.12	No	Yes	0	9	9
142	R:R:I135	R:R:Y131	9.67	Yes	Yes	0	7	8
143	R:R:Y131	R:R:Y214	2.98	Yes	No	0	8	4
144	R:R:A215	R:R:Y131	4	No	Yes	0	7	8
145	R:R:H136	R:R:M132	5.25	Yes	No	0	6	5
146	R:R:I134	R:R:V219	6.14	No	Yes	0	8	8
147	R:R:H136	R:R:I135	6.63	Yes	Yes	0	6	7
148	R:R:I135	R:R:V218	3.07	Yes	No	0	7	4
149	R:R:I135	R:R:T222	4.56	Yes	No	0	7	5
150	R:R:H136	R:R:Q139	9.89	Yes	No	0	6	4
151	R:R:P140	R:R:Q139	3.16	No	No	0	6	4
152	R:R:L157	R:R:V153	2.98	No	No	0	4	3
153	R:R:L161	R:R:V200	2.98	No	No	0	5	5
154	R:R:F163	R:R:P164	5.78	No	No	0	4	8
155	R:R:F163	R:R:Y167	8.25	No	No	0	4	4
156	R:R:Q165	R:R:Y196	10.15	No	Yes	0	6	6
157	R:R:Y167	R:R:Y168	11.91	No	No	0	4	5
158	R:R:P185	R:R:Y168	13.91	No	No	0	4	5
159	R:R:E183	R:R:T170	5.64	No	No	0	3	4
160	R:R:E172	R:R:T173	4.23	No	No	0	3	2
161	R:R:T173	R:R:V178	3.17	No	No	0	2	4
162	R:R:R177	R:R:V179	5.23	Yes	No	0	2	3
163	R:R:I182	R:R:W184	9.4	No	Yes	0	4	5
164	R:R:P185	R:R:W184	5.4	No	Yes	0	4	5
165	R:R:E193	R:R:W184	16.36	No	Yes	0	4	5
166	R:R:W184	R:R:Y196	7.72	Yes	Yes	0	5	6
167	R:R:H187	R:R:P188	16.78	Yes	No	0	2	1
168	R:R:H187	R:R:I191	6.63	Yes	No	8	2	1
169	R:R:H187	R:R:Y192	9.8	Yes	No	8	2	4
170	R:R:E193	R:R:K190	5.4	No	No	7	4	2
171	R:R:K190	R:R:Y272	4.78	No	Yes	7	2	5
172	R:R:I191	R:R:Y192	6.04	No	No	8	1	4
173	R:R:E193	R:R:Y272	12.35	No	Yes	7	4	5
174	R:R:K194	R:R:Y272	5.97	No	Yes	0	3	5
175	R:R:H197	R:R:Y196	3.27	No	Yes	0	5	6
176	R:R:V200	R:R:Y196	7.57	No	Yes	0	5	6
177	R:R:H197	R:R:Y272	13.07	No	Yes	0	5	5
178	R:R:H265	R:R:T201	9.58	Yes	No	0	7	6
179	R:R:L269	R:R:T201	4.42	No	No	0	5	6
180	R:R:H265	R:R:I204	3.98	Yes	No	0	7	6
181	R:R:F206	R:R:Y205	5.16	No	No	0	4	8
182	R:R:L262	R:R:Y205	7.03	No	No	0	5	8
183	R:R:H265	R:R:Y205	8.71	Yes	No	0	7	8
184	R:R:F257	R:R:L209	6.09	No	No	0	9	6
185	R:R:I212	R:R:Y216	7.25	No	Yes	6	8	9
186	R:R:V218	R:R:Y214	7.57	No	No	0	4	4
187	R:R:M250	R:R:Y216	5.99	Yes	Yes	0	8	9
188	R:R:V254	R:R:Y216	3.79	No	Yes	0	8	9
189	R:R:L223	R:R:V219	2.98	No	Yes	0	8	8
190	R:R:M250	R:R:V219	4.56	Yes	Yes	0	8	8
191	R:R:G220	R:R:V247	3.68	No	Yes	0	5	6
192	R:R:K243	R:R:L223	4.23	No	No	0	7	8
193	R:R:R244	R:R:W224	27.99	No	No	0	5	4
194	R:R:V247	R:R:W224	6.13	Yes	No	0	6	4
195	R:R:Q239	R:R:V240	4.3	No	No	0	4	2
196	R:R:K245	R:R:L308	4.23	No	No	0	8	7
197	R:R:M250	R:R:V246	3.04	Yes	No	0	8	7
198	R:R:I304	R:R:M249	10.2	No	No	0	8	8
199	R:R:T256	R:R:Y300	4.99	No	No	0	6	5
200	R:R:F257	R:R:W261	6.01	No	Yes	0	9	8
201	R:R:C260	R:R:I259	3.27	No	No	0	8	5
202	R:R:F264	R:R:W261	10.02	Yes	Yes	1	7	8
203	R:R:H265	R:R:W261	3.17	Yes	Yes	1	7	8
204	R:R:A294	R:R:W261	3.89	No	Yes	1	7	8
205	R:R:S297	R:R:W261	4.94	No	Yes	0	9	8
206	R:R:L262	R:R:P263	3.28	No	No	0	5	9
207	R:R:I266	R:R:L262	7.14	No	No	0	6	5
208	R:R:I290	R:R:P263	3.39	No	No	0	6	9
209	R:R:L293	R:R:P263	3.28	No	No	0	7	9
210	R:R:F264	R:R:H265	3.39	Yes	Yes	1	7	7
211	R:R:F264	R:R:F268	10.72	Yes	No	1	7	6
212	R:R:F264	R:R:M291	3.73	Yes	No	0	7	5
213	R:R:A294	R:R:F264	5.55	No	Yes	1	7	7
214	R:R:F267	R:R:F268	7.5	Yes	No	1	4	6
215	R:R:F267	R:R:Y278	11.35	Yes	Yes	1	4	2
216	R:R:F267	R:R:I283	5.02	Yes	No	1	4	4
217	R:R:F267	R:R:Y287	10.32	Yes	Yes	1	4	5
218	R:R:F267	R:R:I290	7.54	Yes	No	0	4	6
219	R:R:I273	R:R:L270	5.71	No	No	0	5	4
220	R:R:L270	R:R:L277	4.15	No	No	0	4	5
221	R:R:L270	R:R:Y278	7.03	No	Yes	0	4	2
222	R:R:P271	R:R:Y278	13.91	No	Yes	0	4	2
223	R:R:I273	R:R:N274	9.91	No	No	0	5	4
224	R:R:I283	R:R:Y278	8.46	No	Yes	1	4	2
225	R:R:F282	R:R:K280	7.44	No	No	0	3	4
226	R:R:F282	R:R:V286	7.87	No	No	0	3	5
227	R:R:M291	R:R:M295	7.22	No	No	0	5	7
228	R:R:S296	R:R:Y300	3.82	No	No	0	5	5
229	R:R:M299	R:R:Y300	3.59	Yes	No	0	7	5
230	R:R:N301	R:R:Y305	6.98	No	No	0	9	9
231	R:R:F312	R:R:Y305	5.16	No	No	0	9	9
232	R:R:C306	R:R:R313	4.18	No	No	0	7	8
233	R:R:C306	R:R:F316	4.19	No	No	0	7	6
234	R:R:C307	R:R:L308	3.17	No	No	0	6	7
235	R:R:D310	R:R:N309	4.04	No	No	4	4	8
236	R:R:N309	R:R:R311	10.85	No	Yes	4	8	6
237	R:R:F312	R:R:N309	7.25	No	No	0	9	8
238	R:R:D310	R:R:R311	4.76	No	Yes	4	4	6
239	R:R:D310	R:R:L314	4.07	No	No	0	4	4
240	R:R:K317	R:R:R313	9.9	No	No	0	5	8
241	R:R:I304	R:R:L308	2.85	No	No	0	8	7
242	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
243	R:R:A36	R:R:F90	2.77	No	No	0	6	6
244	R:R:L161	R:R:L203	2.77	No	No	0	5	4
245	R:R:K243	R:R:Q239	2.71	No	No	0	7	4
246	R:R:A93	R:R:Y287	2.67	No	Yes	0	5	5
247	R:R:F70	R:R:V150	2.62	Yes	No	0	7	5
248	R:R:F267	R:R:V286	2.62	Yes	No	0	4	5
249	R:R:A38	R:R:W292	2.59	No	No	0	4	5
250	R:R:A319	R:R:W55	2.59	No	Yes	0	4	4
251	R:R:H187	R:R:N189	2.55	Yes	No	0	2	3
252	R:R:V219	R:R:Y131	2.52	Yes	Yes	0	8	8
253	R:R:F312	R:R:I56	2.51	No	Yes	0	9	8
254	R:R:M174	R:R:R177	2.48	No	Yes	0	1	2
255	R:R:R311	R:R:R62	2.13	Yes	No	0	6	5
256	R:R:F76	R:R:W155	2	No	No	0	6	9
257	R:R:G166	R:R:S169	1.86	No	Yes	0	5	5
258	R:R:G49	R:R:V48	1.84	No	No	0	8	4
259	R:R:A114	R:R:A158	1.79	No	No	0	5	8
260	R:R:A114	R:R:A162	1.79	No	No	0	5	7
261	R:R:A118	R:R:A158	1.79	No	No	0	7	8
262	R:R:P175	R:R:S176	1.78	No	No	0	2	5
263	R:R:A82	R:R:S46	1.71	No	No	0	6	8
264	R:R:A77	R:R:S119	1.71	No	No	0	8	9
265	R:R:A146	R:R:S143	1.71	No	No	0	4	7
266	R:R:C199	R:R:V195	1.71	No	No	0	4	4
267	R:R:A82	R:R:V47	1.7	No	No	0	6	6
268	R:R:A83	R:R:V47	1.7	No	No	0	4	6
269	R:R:A79	R:R:V51	1.7	No	No	0	7	4
270	R:R:A75	R:R:V53	1.7	No	No	0	9	8
271	R:R:A144	R:R:V66	1.7	No	No	0	2	6
272	R:R:C260	R:R:T256	1.69	No	No	0	8	6
273	R:R:M174	R:R:P175	1.68	No	No	0	1	2
274	R:R:L207	R:R:P208	1.64	No	No	0	5	9
275	R:R:C255	R:R:I251	1.64	No	No	0	4	5
276	R:R:N50	R:R:P302	1.63	No	No	0	9	9
277	R:R:N274	R:R:P275	1.63	No	No	0	4	3
278	R:R:N301	R:R:P302	1.63	No	No	0	9	9
279	R:R:A118	R:R:I154	1.62	No	No	0	7	7
280	R:R:A125	R:R:I154	1.62	No	No	0	7	7
281	R:R:A115	R:R:M81	1.61	No	No	0	8	7
282	R:R:V43	R:R:V44	1.6	No	No	0	6	4
283	R:R:V43	R:R:V87	1.6	No	No	0	6	8
284	R:R:V44	R:R:V48	1.6	No	No	0	4	4
285	R:R:V47	R:R:V51	1.6	No	No	0	6	4
286	R:R:V51	R:R:V52	1.6	No	No	0	4	6
287	R:R:V149	R:R:V153	1.6	No	No	0	3	3
288	R:R:T40	R:R:V44	1.59	No	No	0	4	4
289	R:R:T145	R:R:V149	1.59	No	No	0	4	3
290	R:R:T171	R:R:V178	1.59	No	No	0	5	4
291	R:R:A146	R:R:L142	1.58	No	No	0	4	6
292	R:R:A258	R:R:L209	1.58	No	No	0	5	6
293	R:R:I191	R:R:V195	1.54	No	No	0	1	4
294	R:R:I251	R:R:V247	1.54	No	Yes	0	5	6
295	R:R:I304	R:R:V253	1.54	No	No	0	8	7
296	R:R:H136	R:R:P137	1.53	Yes	No	0	6	8
297	R:R:L58	R:R:V72	1.49	No	No	0	2	6
298	R:R:L207	R:R:V202	1.49	No	No	0	5	4
299	R:R:L223	R:R:V247	1.49	No	Yes	0	8	6
300	R:R:L102	R:R:T170	1.47	No	No	0	3	4
301	R:R:L142	R:R:T147	1.47	No	No	0	6	7
302	R:R:M249	R:R:M250	1.44	No	Yes	0	8	8
303	R:R:I198	R:R:L269	1.43	No	No	0	5	5
304	R:R:K194	R:R:N189	1.4	No	No	0	3	3
305	R:R:D276	R:R:L279	1.36	No	No	0	1	2
306	L:L:Q5	R:R:L279	1.33	No	No	0	0	2
307	L:L:Q6	R:R:L279	1.33	No	No	0	0	2
308	R:R:A289	R:R:W35	1.3	No	No	0	5	4
309	R:R:T124	R:R:Y121	1.25	No	No	0	7	5
310	R:R:K248	R:R:R244	1.24	No	No	0	6	5
311	R:R:K148	R:R:Y69	1.19	No	No	0	2	5
312	R:R:H318	R:R:W55	1.06	No	Yes	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P2	5.7475	4	2	0
2	L:L:F7	6.75	6	1	0
3	L:L:F8	11.8225	4	2	0
4	L:L:M11	6.5525	4	1	0
5	R:R:N23	7.0125	4	0	8
6	R:R:F25	8.26	5	1	6
7	R:R:Q27	6.064	5	1	4
8	R:R:Q31	6.9075	4	1	2
9	R:R:W55	3.7375	4	0	4
10	R:R:I56	3.3325	4	0	8
11	R:R:F70	6.08	5	0	7
12	R:R:E78	5.44	5	0	9
13	R:R:N89	6.8525	4	0	6
14	R:R:N96	6.3075	4	1	4
15	R:R:W98	8.986	5	5	8
16	R:R:C105	4.935	4	5	9
17	R:R:H108	6.9525	4	0	5
18	R:R:I113	4.5325	4	1	5
19	R:R:Y131	4.7925	4	0	8
20	R:R:I135	5.9825	4	0	7
21	R:R:H136	5.825	4	0	6
22	R:R:S169	4.01	4	0	5
23	R:R:R177	6.1475	4	0	2
24	R:R:W184	9.72	4	0	5
25	R:R:H187	8.94	4	8	2
26	R:R:Y196	7.1775	4	0	6
27	R:R:Y216	5.298	5	6	9
28	R:R:V219	4.05	4	0	8
29	R:R:V247	3.21	4	0	6
30	R:R:M250	3.7575	4	0	8
31	R:R:W261	5.285	6	1	8
32	R:R:F264	6.19	6	1	7
33	R:R:H265	5.766	5	1	7
34	R:R:F267	7.39167	6	1	4
35	R:R:Y272	9.0425	4	7	5
36	R:R:Y278	10.1875	4	1	2
37	R:R:Y287	5.224	5	1	5
38	R:R:M299	5.4175	4	0	7
39	R:R:R311	5.985	4	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q5	R:R:Q24	14.3857	12.8	No	No	0	0	3
2	L:L:F7	R:R:N96	29.2128	10.87	Yes	Yes	1	0	4
3	R:R:N96	R:R:R177	23.7938	3.62	Yes	Yes	0	4	2
4	R:R:R177	R:R:V179	16.0744	5.23	Yes	No	0	2	3
5	L:L:F8	R:R:V179	13.409	7.87	Yes	No	0	0	3
6	R:R:F25	R:R:Q24	19.3163	9.37	Yes	No	0	6	3
7	R:R:N23	R:R:R177	11.5968	13.26	Yes	Yes	0	8	2
8	R:R:F25	R:R:N23	13.3267	3.62	Yes	Yes	0	6	8
9	R:R:F25	R:R:N96	10.7496	7.25	Yes	Yes	1	6	4
10	L:L:F7	R:R:I283	28.5891	3.77	Yes	No	1	0	4
11	L:L:F7	R:R:Q284	32.0487	5.86	Yes	No	1	0	4
12	L:L:F7	R:R:Y287	46.9228	4.13	Yes	Yes	1	0	5
13	R:R:N96	R:R:Y92	26.8828	3.49	Yes	No	0	4	4
14	L:L:M11	R:R:F268	36.7145	9.95	Yes	No	1	0	6
15	R:R:F267	R:R:F268	56.1838	7.5	Yes	No	1	4	6
16	R:R:F267	R:R:I283	25.7884	5.02	Yes	No	1	4	4
17	R:R:F267	R:R:Y287	35.1377	10.32	Yes	Yes	1	4	5
18	L:L:M11	R:R:I113	31.6898	4.37	Yes	Yes	1	0	5
19	L:L:M11	R:R:Q165	30.4542	8.16	Yes	No	1	0	6
20	R:R:F264	R:R:F268	19.7105	10.72	Yes	No	1	7	6
21	R:R:N89	R:R:Y287	33.4314	4.65	Yes	Yes	0	6	5
22	R:R:M291	R:R:N89	52.8948	4.21	No	Yes	0	5	6
23	R:R:F264	R:R:M291	47.6465	3.73	Yes	No	0	7	5
24	R:R:N23	R:R:V26	18.9868	5.91	Yes	No	0	8	1
25	R:R:H95	R:R:V26	17.9395	8.3	No	No	0	5	1
26	R:R:Q27	R:R:Q284	38.1031	15.36	Yes	No	1	4	4
27	R:R:I32	R:R:Q27	31.0956	4.12	No	Yes	0	3	4
28	R:R:H95	R:R:V94	18.7103	4.15	No	No	0	5	5
29	R:R:I32	R:R:V94	30.2777	7.68	No	No	0	3	5
30	R:R:F90	R:R:V94	47.7348	7.87	No	No	0	6	5
31	R:R:F90	R:R:Y39	46.0285	11.35	No	No	0	6	7
32	R:R:W292	R:R:Y39	42.6218	11.58	No	No	0	5	7
33	R:R:I42	R:R:W292	40.9626	11.74	No	No	0	7	5
34	R:R:I42	R:R:M299	39.4328	2.92	No	Yes	0	7	7
35	R:R:M291	R:R:M295	73.0819	7.22	No	No	0	5	7
36	R:R:M295	R:R:T86	75.9237	7.53	No	No	0	7	7
37	R:R:T86	R:R:V43	75.759	3.17	No	No	0	7	6
38	R:R:M299	R:R:S46	39.1445	6.13	Yes	No	0	7	8
39	R:R:S46	R:R:T298	36.3321	6.4	No	No	0	8	9
40	R:R:V43	R:R:V44	75.9826	1.6	No	No	0	6	4
41	R:R:V44	R:R:V48	76.3356	1.6	No	No	0	4	4
42	R:R:G49	R:R:V48	76.5357	1.84	No	No	0	8	4
43	R:R:G49	R:R:P302	76.7887	4.06	No	No	0	8	9
44	R:R:E78	R:R:T298	37.0675	7.06	Yes	No	0	9	9
45	R:R:E78	R:R:N50	11.0438	5.26	Yes	No	0	9	9
46	R:R:N50	R:R:P302	11.2026	1.63	No	No	0	9	9
47	R:R:A82	R:R:S46	16.1332	1.71	No	No	0	6	8
48	R:R:A82	R:R:V47	13.8562	1.7	No	No	0	6	6
49	R:R:A162	R:R:I113	55.9249	3.25	No	Yes	0	7	5
50	R:R:A114	R:R:A162	55.4307	1.79	No	No	0	5	7
51	R:R:A114	R:R:A158	54.9894	1.79	No	No	0	5	8
52	R:R:A118	R:R:A158	54.6129	1.79	No	No	0	7	8
53	R:R:A118	R:R:W155	31.0779	7.78	No	No	0	7	9
54	R:R:E78	R:R:N301	54.4481	3.94	Yes	No	0	9	9
55	R:R:N301	R:R:Y305	100	6.98	No	No	0	9	9
56	R:R:F312	R:R:Y305	34.2492	5.16	No	No	0	9	9
57	R:R:F312	R:R:I56	22.2229	2.51	No	Yes	0	9	8
58	R:R:N301	R:R:P302	66.7157	1.63	No	No	0	9	9
59	R:R:F316	R:R:I56	11.4262	3.77	No	Yes	0	6	8
60	R:R:I56	R:R:W55	10.8849	3.52	Yes	Yes	0	8	4
61	R:R:A118	R:R:I154	24.6646	1.62	No	No	0	7	7
62	R:R:A125	R:R:I154	22.8995	1.62	No	No	0	7	7
63	R:R:A125	R:R:F70	22.6053	6.93	No	Yes	0	7	7
64	R:R:D129	R:R:F70	18.7985	11.94	No	Yes	0	9	7
65	R:R:D129	R:R:R141	17.0864	8.34	No	No	0	9	5
66	R:R:R141	R:R:T67	11.6498	5.17	No	No	0	5	8
67	R:R:F312	R:R:N309	11.438	7.25	No	No	0	9	8
68	R:R:F70	R:R:T147	15.2153	3.89	Yes	No	0	7	7
69	R:R:N73	R:R:W155	29.2363	5.65	No	No	0	9	9
70	R:R:I151	R:R:N73	17.6747	7.08	No	No	0	8	9
71	R:R:L71	R:R:Y305	76.2768	4.69	No	No	0	8	9
72	R:R:L71	R:R:V126	74.9	2.98	No	No	0	8	9
73	R:R:E78	R:R:L74	43.6397	6.63	Yes	No	0	9	9
74	R:R:L74	R:R:S122	42.4982	3	No	No	0	9	8
75	R:R:N73	R:R:S122	42.7807	7.45	No	No	0	9	8
76	R:R:E78	R:R:S119	15.3507	4.31	Yes	No	0	9	9
77	R:R:F264	R:R:W261	14.0798	10.02	Yes	Yes	1	7	8
78	R:R:F111	R:R:P112	10.2848	5.78	No	No	0	4	6
79	R:R:H108	R:R:N89	22.3288	7.65	Yes	Yes	0	5	6
80	R:R:W98	R:R:Y92	22.1817	8.68	Yes	No	0	8	4
81	R:R:W98	R:R:Y100	12.3441	12.54	Yes	No	0	8	7
82	R:R:C105	R:R:W98	24.5587	3.92	Yes	Yes	5	9	8
83	R:R:Y100	R:R:Y104	12.3323	4.96	No	No	0	7	5
84	R:R:C105	R:R:T171	15.6037	3.38	Yes	No	0	9	5
85	R:R:C105	R:R:S169	14.1033	5.16	Yes	Yes	0	9	5
86	R:R:N109	R:R:S169	10.8202	5.96	No	Yes	0	5	5
87	R:R:I182	R:R:N109	11.2379	5.66	No	No	0	4	5
88	R:R:I182	R:R:W184	11.9911	9.4	No	Yes	0	4	5
89	R:R:P185	R:R:W184	16.1391	5.4	No	Yes	0	4	5
90	R:R:P185	R:R:Y168	13.868	13.91	No	No	0	4	5
91	R:R:Y167	R:R:Y168	11.5851	11.91	No	No	0	4	5
92	R:R:F264	R:R:H265	19.4046	3.39	Yes	Yes	1	7	7
93	R:R:I120	R:R:S119	10.2789	3.1	No	No	0	7	9
94	R:R:R130	R:R:V126	73.5232	6.54	No	No	0	9	9
95	R:R:R130	R:R:Y216	72.1758	4.12	No	Yes	0	9	9
96	R:R:M250	R:R:Y216	61.538	5.99	Yes	Yes	0	8	9
97	R:R:M250	R:R:V219	48.4467	4.56	Yes	Yes	0	8	8
98	R:R:V219	R:R:Y131	25.2236	2.52	Yes	Yes	0	8	8
99	R:R:I135	R:R:Y131	17.6218	9.67	Yes	Yes	0	7	8
100	R:R:H136	R:R:I135	11.891	6.63	Yes	Yes	0	6	7
101	R:R:Q165	R:R:Y196	51.2768	10.15	No	Yes	0	6	6
102	R:R:H197	R:R:Y196	22.5053	3.27	No	Yes	0	5	6
103	R:R:H197	R:R:Y272	20.3048	13.07	No	Yes	0	5	5
104	R:R:K194	R:R:Y272	18.7103	5.97	No	Yes	0	3	5
105	R:R:K194	R:R:N189	16.4274	1.4	No	No	0	3	3
106	R:R:H187	R:R:N189	14.1151	2.55	Yes	No	0	2	3
107	R:R:F267	R:R:I290	11.4674	7.54	Yes	No	0	4	6
108	R:R:L223	R:R:V219	21.4815	2.98	No	Yes	0	8	8
109	R:R:L223	R:R:V247	13.8327	1.49	No	Yes	0	8	6
110	R:R:M249	R:R:M250	11.8381	1.44	No	Yes	0	8	8
111	R:R:M299	R:R:Y300	13.0854	3.59	Yes	No	0	7	5
112	R:R:L270	R:R:Y278	11.3497	7.03	No	Yes	0	4	2
113	L:L:F7	R:R:F25	21.7522	12.86	Yes	Yes	1	0	6
114	R:R:H108	R:R:Y104	13.4855	3.27	Yes	No	0	5	5
115	R:R:W184	R:R:Y196	26.5533	7.72	Yes	Yes	0	5	6
116	R:R:F267	R:R:Y278	12.1852	11.35	Yes	Yes	1	4	2
117	L:L:M11	R:R:F264	26.2532	3.73	Yes	Yes	1	0	7
118	R:R:I113	R:R:Q165	22.5524	5.49	Yes	No	1	5	6
119	R:R:F70	R:R:I151	15.9155	5.02	Yes	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:M181	6.71	2	Yes	No	0	4	0	1
L:L:Q5	R:R:Q24	12.8	0	No	No	0	3	0	1
L:L:F7	R:R:F25	12.86	1	Yes	Yes	0	6	0	1
L:L:F7	R:R:N96	10.87	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:I283	3.77	1	Yes	No	0	4	0	1
L:L:F7	R:R:Q284	5.86	1	Yes	No	0	4	0	1
L:L:F7	R:R:Y287	4.13	1	Yes	Yes	0	5	0	1
L:L:F8	R:R:V179	7.87	2	Yes	No	0	3	0	1
L:L:F8	R:R:M181	9.95	2	Yes	No	0	4	0	1
L:L:G9	R:R:Y287	4.35	1	No	Yes	0	5	0	1
L:L:L10	R:R:Y92	4.69	0	No	No	0	4	0	1
L:L:M11	R:R:I113	4.37	1	Yes	Yes	0	5	0	1
L:L:M11	R:R:Q165	8.16	1	Yes	No	0	6	0	1
L:L:M11	R:R:F264	3.73	1	Yes	Yes	0	7	0	1
L:L:M11	R:R:F268	9.95	1	Yes	No	0	6	0	1
R:R:F25	R:R:N23	3.62	1	Yes	Yes	6	8	1	2
R:R:N23	R:R:R177	13.26	0	Yes	Yes	8	2	2	2
R:R:F25	R:R:Q24	9.37	1	Yes	No	6	3	1	1
R:R:K281	R:R:Q24	6.78	0	No	No	2	3	2	1
R:R:F25	R:R:N96	7.25	1	Yes	Yes	6	4	1	1
R:R:F25	R:R:Q284	8.2	1	Yes	No	6	4	1	1
R:R:Q27	R:R:Q284	15.36	1	Yes	No	4	4	2	1
R:R:N89	R:R:Y287	4.65	0	Yes	Yes	6	5	2	1
R:R:M291	R:R:N89	4.21	0	No	Yes	5	6	2	2
R:R:N96	R:R:Y92	3.49	1	Yes	No	4	4	1	1
R:R:W98	R:R:Y92	8.68	5	Yes	No	8	4	2	1
R:R:N96	R:R:R177	3.62	1	Yes	Yes	4	2	1	2
R:R:F117	R:R:I113	5.02	0	No	Yes	7	5	2	1
R:R:A162	R:R:I113	3.25	0	No	Yes	7	5	2	1
R:R:I113	R:R:Q165	5.49	1	Yes	No	5	6	1	1
R:R:Q165	R:R:Y196	10.15	1	No	Yes	6	6	1	2
R:R:R177	R:R:V179	5.23	0	Yes	No	2	3	2	1
R:R:F264	R:R:W261	10.02	1	Yes	Yes	7	8	1	2
R:R:H265	R:R:W261	3.17	1	Yes	Yes	7	8	2	2
R:R:A294	R:R:W261	3.89	1	No	Yes	7	8	2	2
R:R:F264	R:R:H265	3.39	1	Yes	Yes	7	7	1	2
R:R:F264	R:R:F268	10.72	1	Yes	No	7	6	1	1
R:R:F264	R:R:M291	3.73	1	Yes	No	7	5	1	2
R:R:A294	R:R:F264	5.55	1	No	Yes	7	7	2	1
R:R:F267	R:R:F268	7.5	1	Yes	No	4	6	2	1
R:R:F267	R:R:Y278	11.35	1	Yes	Yes	4	2	2	2
R:R:F267	R:R:I283	5.02	1	Yes	No	4	4	2	1
R:R:F267	R:R:Y287	10.32	1	Yes	Yes	4	5	2	1
R:R:I283	R:R:Y278	8.46	1	No	Yes	4	2	1	2
R:R:A93	R:R:Y287	2.67	0	No	Yes	5	5	2	1
R:R:D276	R:R:L279	1.36	0	No	No	1	2	2	1
L:L:Q5	R:R:L279	1.33	0	No	No	0	2	0	1
L:L:Q6	R:R:L279	1.33	2	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U26_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	275
Number of Links	312
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	120
Number Of Links MetaPath	119
Number of Shortest Paths	53883
Length Of Smallest Path	3
Average Path Length	14.8647
Length of Longest Path	33
Minimum Path Strength	1.33
Average Path Strength	5.67236
Maximum Path Strength	17.06
Minimum Path Correlation	0.7
Average Path Correlation	0.929148
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.7697
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.7719
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • tachykinin receptor activity • neuropeptide receptor activity • substance P receptor activity • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of systemic arterial blood pressure by hormone • regulation of blood volume by renin-angiotensin • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • feeding behavior • brain renin-angiotensin system • behavior • regulation of systemic arterial blood pressure • circulatory system process • endocrine process • drinking behavior • angiotensin-mediated drinking behavior • regulation of biological quality • nervous system process involved in regulation of systemic arterial blood pressure • blood circulation • positive regulation of cell communication • regulation of localization • regulation of hormone secretion • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • positive regulation of signaling • regulation of tube diameter • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • response to steroid hormone • response to progesterone • regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • smooth muscle cell proliferation • regulation of cell motility • regulation of smooth muscle cell migration • smooth muscle cell migration • muscle cell migration • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • excretion • micturition • renal system process • smooth muscle contraction involved in micturition • urinary bladder smooth muscle contraction • muscle contraction • muscle system process • smooth muscle contraction • urinary tract smooth muscle contraction • response to stress • multicellular organismal response to stress • response to pain • behavioral response to pain • multi-multicellular organism process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • response to electrical stimulus • response to abiotic stimulus • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • positive regulation of lymphocyte activation • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • regulation of immune system process • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • cell activation • positive regulation of lymphocyte proliferation • mononuclear cell proliferation • immune system process • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • regulation of lymphocyte activation • regulation of vascular permeability • positive regulation of vascular permeability • tachykinin receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • detection of stimulus • detection of abiotic stimulus • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • response to oxidative stress • response to ozone • response to reactive oxygen species • positive regulation of blood pressure • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of muscle system process • uterine smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • eating behavior • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • response to ethanol • learning or memory • long-term memory • cognition • memory • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • positive regulation of locomotion • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of cell migration • leukocyte migration • positive regulation of cell motility • response to auditory stimulus • response to mechanical stimulus • response to external stimulus • regulation of reproductive process • regulation of cilium-dependent cell motility • positive regulation of flagellated sperm motility • cilium or flagellum-dependent cell motility • regulation of flagellated sperm motility • cilium-dependent cell motility • positive regulation of cilium movement • positive regulation of reproductive process • sperm motility • positive regulation of cilium-dependent cell motility • regulation of microtubule-based process • regulation of microtubule-based movement • cilium movement involved in cell motility • regulation of cilium movement • flagellated sperm motility • microtubule-based movement • microtubule-based process • cilium movement • regulation of cilium movement involved in cell motility • aggressive behavior • learning • associative learning • ossification • positive regulation of ossification • regulation of ossification • defense response • inflammatory response • response to nicotine • operant conditioning • positive regulation of synaptic transmission, cholinergic • synaptic transmission, cholinergic • regulation of synaptic transmission, cholinergic • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • positive regulation of supramolecular fiber organization • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • response to estradiol • positive regulation of epithelial cell migration • tissue migration • ameboidal-type cell migration • epithelial cell migration • regulation of epithelial cell migration • epithelium migration • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • 9+2 motile cilium • sperm flagellum • motile cilium • somatodendritic compartment • dendrite • dendritic tree • sperm midpiece • cell body • sperm head • cell surface • signaling receptor binding • substance P receptor binding • neurokinin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • regulation of defense response • regulation of response to external stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • positive regulation of defense response • regulation of acute inflammatory response • acute inflammatory response • cellular response to growth factor stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • sensory perception of pain • heart process • negative regulation of heart rate • regulation of heart contraction • negative regulation of biological process • negative regulation of blood circulation • negative regulation of heart contraction • heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • corticosterone secretion • positive regulation of steroid hormone secretion • regulation of glucocorticoid secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • positive regulation of corticosterone secretion • lipid localization • positive regulation of lipid localization • regulation of lipid localization • macromolecule localization • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • neuronal cell body • axon
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25103
Sequence	>8U26_nogp_Chain_R N Q F V Q P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H K R M R T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N E W Y Y G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H P L Q P R L S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S T T E T M P S R V V C M I E W P E H P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N P D L Y L K K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F R L G F K H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6HLL	A	Peptide	Tachykinin	NK₁	Homo sapiens	CP99994	-	-	3.27	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLO	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.4	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLP	A	Peptide	Tachykinin	NK₁	Homo sapiens	Netupitant	-	-	2.2	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6J20	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.7	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	6J21	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	3.2	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	7RMG	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMG (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	8U26	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	Gs/β1/γ2	2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	8U26 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	6E59	A	Peptide	Tachykinin	NK₁	Homo sapiens	L-760735	-	-	3.4	2018-12-12	doi.org/10.1073/pnas.1812717115
	7P00	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P00 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	chim(NtGi1-Gs)/β1/γ2	2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872

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