psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F8	L:L:Q6	9.37	No	No	0	0	0
2	L:L:F7	R:R:F25	8.57	Yes	Yes	1	0	6
3	L:L:F7	R:R:N96	8.46	Yes	Yes	1	0	4
4	L:L:F7	R:R:Q284	7.03	Yes	Yes	1	0	4
5	L:L:F7	R:R:Y287	10.32	Yes	Yes	0	0	5
6	L:L:F8	R:R:V179	6.55	No	No	0	0	3
7	L:L:F8	R:R:M181	7.46	No	No	0	0	4
8	L:L:G9	R:R:Y287	5.79	No	Yes	0	0	5
9	L:L:L10	R:R:Y92	4.69	No	No	0	0	4
10	L:L:L10	R:R:H108	5.14	No	Yes	0	0	5
11	L:L:M11	R:R:I113	4.37	No	Yes	3	0	5
12	L:L:M11	R:R:Q165	5.44	No	Yes	3	0	6
13	L:L:M11	R:R:F268	11.2	No	No	0	0	6
14	L:L:?12	R:R:N85	10.2	No	No	2	0	6
15	L:L:?12	R:R:N89	10.2	No	Yes	2	0	6
16	L:L:?12	R:R:H108	9.55	No	Yes	2	0	5
17	R:R:N23	R:R:V26	4.43	No	No	0	8	1
18	R:R:F25	R:R:Q24	10.54	Yes	No	0	6	3
19	R:R:K281	R:R:Q24	8.14	No	No	0	2	3
20	R:R:F25	R:R:N96	4.83	Yes	Yes	1	6	4
21	R:R:F25	R:R:R177	6.41	Yes	Yes	1	6	2
22	R:R:F25	R:R:Q284	12.88	Yes	Yes	1	6	4
23	R:R:H95	R:R:V26	4.15	No	No	0	5	1
24	R:R:Q27	R:R:Q284	12.8	No	Yes	0	4	4
25	R:R:Q27	R:R:Q285	7.68	No	No	0	4	1
26	R:R:P28	R:R:W30	6.76	No	No	0	2	1
27	R:R:Q31	R:R:W30	5.48	No	No	0	2	1
28	R:R:Q31	R:R:W35	8.76	No	Yes	4	2	4
29	R:R:Q285	R:R:Q31	7.68	No	No	4	1	2
30	R:R:I32	R:R:V94	4.61	No	No	0	3	5
31	R:R:Q285	R:R:W35	4.38	No	Yes	4	1	4
32	R:R:L288	R:R:W35	12.53	No	Yes	0	3	4
33	R:R:F90	R:R:Y39	18.57	No	No	0	6	7
34	R:R:L288	R:R:Y39	4.69	No	No	0	3	7
35	R:R:W292	R:R:Y39	6.75	Yes	No	0	5	7
36	R:R:I42	R:R:W292	5.87	No	Yes	0	7	5
37	R:R:I42	R:R:M299	4.37	No	No	0	7	7
38	R:R:S46	R:R:T298	7.99	No	No	0	8	9
39	R:R:G49	R:R:P302	4.06	No	No	0	8	9
40	R:R:E78	R:R:N50	5.26	Yes	No	0	9	9
41	R:R:F316	R:R:V52	6.55	No	No	0	6	6
42	R:R:A59	R:R:W55	5.19	No	Yes	0	4	4
43	R:R:H318	R:R:W55	9.52	No	Yes	0	3	4
44	R:R:H60	R:R:I56	3.98	No	Yes	0	5	8
45	R:R:I57	R:R:V72	4.61	No	No	0	7	6
46	R:R:L58	R:R:V72	4.47	No	No	0	2	6
47	R:R:K61	R:R:R64	8.66	No	No	0	6	6
48	R:R:M63	R:R:N68	7.01	No	No	0	7	8
49	R:R:M63	R:R:R311	6.2	No	No	0	7	6
50	R:R:T65	R:R:T67	9.42	No	No	0	7	8
51	R:R:V66	R:R:Y69	6.31	No	No	0	6	5
52	R:R:N68	R:R:T67	7.31	No	No	0	8	8
53	R:R:R141	R:R:T67	5.17	No	No	0	5	8
54	R:R:T147	R:R:Y69	4.99	No	No	0	7	5
55	R:R:A125	R:R:F70	8.32	No	Yes	0	7	7
56	R:R:F70	R:R:T147	3.89	Yes	No	0	7	7
57	R:R:F70	R:R:V150	5.24	Yes	No	0	7	5
58	R:R:F70	R:R:I151	5.02	Yes	No	0	7	8
59	R:R:L71	R:R:Y305	9.38	No	No	0	8	9
60	R:R:N73	R:R:S122	4.47	No	No	0	9	8
61	R:R:I151	R:R:N73	9.91	No	No	0	8	9
62	R:R:N73	R:R:W155	7.91	No	No	0	9	9
63	R:R:E78	R:R:L74	5.3	Yes	Yes	0	9	9
64	R:R:L74	R:R:S122	7.51	Yes	No	0	9	8
65	R:R:L74	R:R:M123	4.24	Yes	No	0	9	8
66	R:R:L74	R:R:N301	6.87	Yes	No	0	9	9
67	R:R:F76	R:R:S80	7.93	No	No	0	6	6
68	R:R:F76	R:R:W155	5.01	No	No	0	6	9
69	R:R:E78	R:R:M81	6.77	Yes	Yes	0	9	7
70	R:R:E78	R:R:S119	4.31	Yes	No	0	9	9
71	R:R:F111	R:R:S80	5.28	Yes	No	0	4	6
72	R:R:M81	R:R:V116	7.61	Yes	No	0	7	7
73	R:R:M295	R:R:M81	5.78	No	Yes	0	7	7
74	R:R:F111	R:R:F84	4.29	Yes	No	0	4	5
75	R:R:N85	R:R:N89	9.54	No	Yes	2	6	6
76	R:R:N85	R:R:P112	4.89	No	No	0	6	6
77	R:R:M295	R:R:T86	7.53	No	No	0	7	7
78	R:R:V88	R:R:Y104	5.05	No	No	0	5	5
79	R:R:H108	R:R:V88	9.69	Yes	No	0	5	5
80	R:R:H108	R:R:N89	8.93	Yes	Yes	2	5	6
81	R:R:N89	R:R:Y287	4.65	Yes	Yes	0	6	5
82	R:R:F90	R:R:V94	7.87	No	No	0	6	5
83	R:R:T91	R:R:Y100	6.24	No	Yes	0	4	7
84	R:R:N96	R:R:Y92	5.81	Yes	No	0	4	4
85	R:R:W98	R:R:Y92	13.5	Yes	No	0	8	4
86	R:R:H95	R:R:V94	6.92	No	No	0	5	5
87	R:R:N96	R:R:R177	9.64	Yes	Yes	1	4	2
88	R:R:E97	R:R:Y99	14.59	No	No	0	4	2
89	R:R:W98	R:R:Y100	16.4	Yes	Yes	0	8	7
90	R:R:C105	R:R:W98	3.92	Yes	Yes	5	9	8
91	R:R:C180	R:R:W98	14.37	No	Yes	5	9	8
92	R:R:Y100	R:R:Y99	3.97	Yes	No	0	7	2
93	R:R:Y100	R:R:Y104	7.94	Yes	No	0	7	5
94	R:R:F107	R:R:Y104	6.19	No	No	0	4	5
95	R:R:C105	R:R:S169	5.16	Yes	No	0	9	5
96	R:R:C105	R:R:C180	7.28	Yes	No	5	9	9
97	R:R:F107	R:R:F111	6.43	No	Yes	0	4	4
98	R:R:N109	R:R:S169	8.94	No	No	0	5	5
99	R:R:F110	R:R:L159	6.09	No	No	0	6	4
100	R:R:F110	R:R:F163	5.36	No	No	0	6	4
101	R:R:F111	R:R:P112	5.78	Yes	No	0	4	6
102	R:R:F117	R:R:I113	5.02	Yes	Yes	0	7	5
103	R:R:I113	R:R:Q165	8.23	Yes	Yes	3	5	6
104	R:R:A114	R:R:L159	4.73	No	No	0	5	4
105	R:R:F117	R:R:V200	5.24	Yes	No	0	7	5
106	R:R:F117	R:R:I204	15.07	Yes	No	0	7	6
107	R:R:A118	R:R:W155	7.78	No	No	0	7	9
108	R:R:R130	R:R:V126	6.54	Yes	No	0	9	9
109	R:R:A127	R:R:I212	4.87	No	No	6	9	8
110	R:R:A127	R:R:Y216	4	No	Yes	6	9	9
111	R:R:R130	R:R:Y305	4.12	Yes	No	0	9	9
112	R:R:I135	R:R:Y131	7.25	No	Yes	0	7	8
113	R:R:A215	R:R:Y131	4	No	Yes	0	7	8
114	R:R:V218	R:R:Y131	5.05	No	Yes	0	4	8
115	R:R:H136	R:R:M132	3.94	Yes	No	0	6	5
116	R:R:I134	R:R:V219	7.68	No	No	0	8	8
117	R:R:I134	R:R:L223	7.14	No	No	0	8	8
118	R:R:H136	R:R:I135	10.61	Yes	No	0	6	7
119	R:R:I135	R:R:T222	4.56	No	No	0	7	5
120	R:R:R141	R:R:T147	3.88	No	No	0	5	7
121	R:R:A146	R:R:L142	4.73	No	No	0	4	6
122	R:R:F163	R:R:P164	4.33	No	No	0	4	8
123	R:R:F163	R:R:Y167	7.22	No	No	0	4	4
124	R:R:P164	R:R:Y196	5.56	No	Yes	0	8	6
125	R:R:I182	R:R:Q165	5.49	No	Yes	0	4	6
126	R:R:Q165	R:R:Y196	11.27	Yes	Yes	0	6	6
127	R:R:Y167	R:R:Y168	12.91	No	No	0	4	5
128	R:R:W184	R:R:Y168	4.82	Yes	No	0	5	5
129	R:R:P185	R:R:Y168	11.13	No	No	0	4	5
130	R:R:E183	R:R:T170	8.47	No	No	0	3	4
131	R:R:E172	R:R:M174	10.83	No	Yes	0	3	1
132	R:R:M174	R:R:R177	6.2	Yes	Yes	1	1	2
133	R:R:M174	R:R:V179	6.09	Yes	No	1	1	3
134	R:R:R177	R:R:V179	3.92	Yes	No	1	2	3
135	R:R:I182	R:R:W184	9.4	No	Yes	0	4	5
136	R:R:E193	R:R:W184	16.36	No	Yes	0	4	5
137	R:R:W184	R:R:Y196	10.61	Yes	Yes	0	5	6
138	R:R:H187	R:R:I191	7.95	No	No	0	2	1
139	R:R:H187	R:R:Y192	7.62	No	No	0	2	4
140	R:R:E193	R:R:K190	5.4	No	No	0	4	2
141	R:R:E193	R:R:Y272	6.73	No	No	0	4	5
142	R:R:K194	R:R:V195	7.59	Yes	No	0	3	4
143	R:R:V200	R:R:Y196	7.57	No	Yes	0	5	6
144	R:R:H197	R:R:Y272	14.16	No	No	0	5	5
145	R:R:H265	R:R:T201	8.21	No	No	0	7	6
146	R:R:L269	R:R:T201	7.37	No	No	0	5	6
147	R:R:H265	R:R:I204	5.3	No	No	0	7	6
148	R:R:F206	R:R:Y205	5.16	No	Yes	0	4	8
149	R:R:L209	R:R:Y205	4.69	No	Yes	0	6	8
150	R:R:L262	R:R:Y205	7.03	No	Yes	0	5	8
151	R:R:H265	R:R:Y205	7.62	No	Yes	0	7	8
152	R:R:F257	R:R:L209	7.31	No	No	0	9	6
153	R:R:I212	R:R:Y216	8.46	No	Yes	6	8	9
154	R:R:V218	R:R:Y214	6.31	No	No	0	4	4
155	R:R:M250	R:R:Y216	15.57	Yes	Yes	0	8	9
156	R:R:M250	R:R:V219	4.56	Yes	No	0	8	8
157	R:R:G220	R:R:V247	5.52	No	No	0	5	6
158	R:R:K243	R:R:L223	7.05	No	No	0	7	8
159	R:R:R244	R:R:W224	9	No	No	0	5	4
160	R:R:V247	R:R:W224	6.13	No	No	0	6	4
161	R:R:E238	R:R:V240	4.28	No	No	0	3	2
162	R:R:L308	R:R:M249	4.24	No	Yes	0	7	8
163	R:R:T256	R:R:Y300	9.99	No	No	0	6	5
164	R:R:F257	R:R:W261	8.02	No	Yes	0	9	8
165	R:R:F264	R:R:W261	10.02	Yes	Yes	7	7	8
166	R:R:A294	R:R:W261	3.89	No	Yes	7	7	8
167	R:R:S297	R:R:W261	6.18	No	Yes	0	9	8
168	R:R:I266	R:R:L262	7.14	No	No	0	6	5
169	R:R:I290	R:R:P263	6.77	No	No	0	6	9
170	R:R:L293	R:R:P263	4.93	No	No	0	7	9
171	R:R:F264	R:R:F268	10.72	Yes	No	0	7	6
172	R:R:F264	R:R:M291	6.22	Yes	No	0	7	5
173	R:R:A294	R:R:F264	5.55	No	Yes	7	7	7
174	R:R:F267	R:R:F268	5.36	Yes	No	0	4	6
175	R:R:F267	R:R:Y278	6.19	Yes	Yes	8	4	2
176	R:R:F267	R:R:I283	6.28	Yes	No	8	4	4
177	R:R:F267	R:R:Y287	7.22	Yes	Yes	0	4	5
178	R:R:F267	R:R:I290	5.02	Yes	No	0	4	6
179	R:R:L270	R:R:L277	4.15	No	No	0	4	5
180	R:R:P271	R:R:Y272	4.17	No	No	0	4	5
181	R:R:P271	R:R:Y278	9.74	No	Yes	0	4	2
182	R:R:I273	R:R:N274	15.58	No	No	0	5	4
183	R:R:I283	R:R:Y278	9.67	No	Yes	8	4	2
184	R:R:K281	R:R:Q284	4.07	No	Yes	0	2	4
185	R:R:F282	R:R:V286	5.24	No	No	0	3	5
186	R:R:M291	R:R:Y287	4.79	No	Yes	0	5	5
187	R:R:M291	R:R:M295	4.33	No	No	0	5	7
188	R:R:S296	R:R:W292	4.94	No	Yes	0	5	5
189	R:R:F312	R:R:Y305	4.13	Yes	No	0	9	9
190	R:R:C306	R:R:F316	4.19	No	No	0	7	6
191	R:R:N309	R:R:R311	13.26	No	No	0	8	6
192	R:R:F312	R:R:N309	7.25	Yes	No	0	9	8
193	R:R:D310	R:R:R313	5.96	No	No	0	4	8
194	R:R:V254	R:R:Y216	3.79	No	Yes	0	8	9
195	R:R:F312	R:R:I57	3.77	Yes	No	0	9	7
196	R:R:F257	R:R:I120	3.77	No	No	0	9	7
197	R:R:F76	R:R:M54	3.73	No	No	0	6	7
198	R:R:F128	R:R:M132	3.73	No	No	0	5	5
199	R:R:H136	R:R:Q139	3.71	Yes	No	0	6	4
200	R:R:I154	R:R:Y121	3.63	No	No	0	7	5
201	R:R:I204	R:R:Y121	3.63	No	No	0	6	5
202	R:R:P302	R:R:V53	3.53	No	No	0	9	8
203	R:R:G315	R:R:I56	3.53	No	Yes	0	6	8
204	R:R:I56	R:R:W55	3.52	Yes	Yes	0	8	4
205	R:R:L270	R:R:Y278	3.52	No	Yes	0	4	2
206	R:R:C260	R:R:S296	3.44	No	No	0	8	5
207	R:R:A82	R:R:S46	3.42	No	No	0	6	8
208	R:R:A319	R:R:V52	3.39	No	No	0	4	6
209	R:R:A144	R:R:V66	3.39	No	No	0	2	6
210	R:R:I120	R:R:P208	3.39	No	No	0	7	9
211	R:R:C105	R:R:T171	3.38	Yes	No	0	9	5
212	R:R:A162	R:R:I113	3.25	No	Yes	0	7	5
213	R:R:D276	R:R:P275	3.22	No	No	0	1	3
214	R:R:T86	R:R:V43	3.17	No	No	0	7	6
215	R:R:P140	R:R:Q139	3.16	No	No	0	6	4
216	R:R:A258	R:R:L209	3.15	No	No	0	5	6
217	R:R:A79	R:R:N50	3.13	No	No	0	7	9
218	R:R:R130	R:R:Y216	3.09	Yes	Yes	0	9	9
219	R:R:I57	R:R:V53	3.07	No	No	0	7	8
220	R:R:I283	R:R:V286	3.07	No	No	0	4	5
221	R:R:K106	R:R:S169	3.06	No	No	0	6	5
222	R:R:M299	R:R:T45	3.01	No	No	0	7	4
223	R:R:M81	R:R:T298	3.01	Yes	No	0	7	9
224	R:R:M299	R:R:T298	3.01	No	No	0	7	9
225	R:R:L102	R:R:T171	2.95	No	No	0	3	5
226	R:R:I304	R:R:M249	2.92	No	Yes	0	8	8
227	R:R:I191	R:R:K194	2.91	No	Yes	0	1	3
228	R:R:W184	R:R:Y192	2.89	Yes	No	0	5	4
229	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
230	R:R:A36	R:R:F90	2.77	No	No	0	6	6
231	R:R:C260	R:R:Y300	2.69	No	No	0	8	5
232	R:R:A93	R:R:Y287	2.67	No	Yes	0	5	5
233	R:R:F320	R:R:V48	2.62	No	No	0	6	4
234	R:R:F206	R:R:V202	2.62	No	No	0	4	4
235	R:R:A38	R:R:W292	2.59	No	Yes	0	4	5
236	R:R:A319	R:R:W55	2.59	No	Yes	0	4	4
237	R:R:V219	R:R:Y131	2.52	No	Yes	0	8	8
238	R:R:V253	R:R:Y216	2.52	No	Yes	0	7	9
239	R:R:F312	R:R:I56	2.51	Yes	Yes	0	9	8
240	R:R:F117	R:R:L161	2.44	Yes	No	0	7	5
241	R:R:L58	R:R:R64	2.43	No	No	0	2	6
242	R:R:L142	R:R:R141	2.43	No	No	0	6	5
243	R:R:L203	R:R:Y121	2.34	No	No	0	4	5
244	R:R:G49	R:R:V48	1.84	No	No	0	8	4
245	R:R:A114	R:R:A158	1.79	No	No	0	5	8
246	R:R:A118	R:R:A158	1.79	No	No	0	7	8
247	R:R:G213	R:R:I212	1.76	No	No	0	4	8
248	R:R:P208	R:R:T124	1.75	No	No	0	9	7
249	R:R:G220	R:R:M250	1.75	No	Yes	0	5	8
250	R:R:A77	R:R:S119	1.71	No	No	0	8	9
251	R:R:A115	R:R:S80	1.71	No	No	0	8	6
252	R:R:C152	R:R:V156	1.71	No	No	0	3	3
253	R:R:C199	R:R:V195	1.71	No	No	0	4	4
254	R:R:A82	R:R:V47	1.7	No	No	0	6	6
255	R:R:A83	R:R:V47	1.7	No	No	0	4	6
256	R:R:A75	R:R:V53	1.7	No	No	0	9	8
257	R:R:G166	R:R:N109	1.7	No	No	0	5	5
258	R:R:M174	R:R:P175	1.68	Yes	No	0	1	2
259	R:R:L207	R:R:P208	1.64	No	No	0	5	9
260	R:R:C255	R:R:I251	1.64	No	No	0	4	5
261	R:R:N274	R:R:P275	1.63	No	No	0	4	3
262	R:R:C307	R:R:M249	1.62	No	Yes	0	6	8
263	R:R:V44	R:R:V48	1.6	No	No	0	4	4
264	R:R:V149	R:R:V153	1.6	No	No	0	3	3
265	R:R:T40	R:R:V44	1.59	No	No	0	4	4
266	R:R:T124	R:R:V211	1.59	No	No	0	7	6
267	R:R:T171	R:R:V178	1.59	No	No	0	5	4
268	R:R:A133	R:R:D129	1.54	No	No	0	8	9
269	R:R:I251	R:R:V247	1.54	No	No	0	5	6
270	R:R:I304	R:R:V253	1.54	No	No	0	8	7
271	R:R:H136	R:R:P137	1.53	Yes	No	0	6	8
272	R:R:H187	R:R:P188	1.53	No	No	0	2	1
273	R:R:K148	R:R:V149	1.52	No	No	0	2	3
274	R:R:I221	R:R:T217	1.52	No	No	0	3	3
275	R:R:M250	R:R:V246	1.52	Yes	No	0	8	7
276	R:R:K248	R:R:V252	1.52	No	No	0	6	5
277	R:R:N23	R:R:S176	1.49	No	No	0	8	5
278	R:R:L157	R:R:V153	1.49	No	No	0	4	3
279	R:R:I198	R:R:K194	1.45	No	Yes	0	5	3
280	R:R:K245	R:R:M249	1.44	No	Yes	0	8	8
281	R:R:K280	R:R:K281	1.44	No	No	0	4	2
282	R:R:K280	R:R:L279	1.41	No	No	0	4	2
283	R:R:K194	R:R:N189	1.4	Yes	No	0	3	3
284	R:R:C306	R:R:R313	1.39	No	No	0	7	8
285	R:R:L277	R:R:N274	1.37	No	No	0	5	4
286	R:R:A289	R:R:W35	1.3	No	Yes	0	5	4
287	R:R:E238	R:R:Q239	1.27	No	No	0	3	4
288	R:R:D129	R:R:R130	1.19	No	Yes	0	9	9
289	R:R:L34	R:R:W30	1.14	No	No	0	4	1
290	R:R:H60	R:R:R62	1.13	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F7	8.595	4	1	0
2	R:R:F25	8.646	5	1	6
3	R:R:W35	6.7425	4	4	4
4	R:R:W55	5.205	4	0	4
5	R:R:I56	3.385	4	0	8
6	R:R:F70	5.6175	4	0	7
7	R:R:L74	5.98	4	0	9
8	R:R:E78	5.41	4	0	9
9	R:R:M81	5.7925	4	0	7
10	R:R:N89	8.33	4	2	6
11	R:R:N96	7.185	4	1	4
12	R:R:W98	10.2	5	5	8
13	R:R:Y100	8.6375	4	0	7
14	R:R:C105	4.935	4	5	9
15	R:R:H108	8.3275	4	2	5
16	R:R:F111	5.445	4	0	4
17	R:R:I113	5.2175	4	3	5
18	R:R:F117	6.9425	4	0	7
19	R:R:R130	3.735	4	0	9
20	R:R:Y131	4.705	4	0	8
21	R:R:H136	4.9475	4	0	6
22	R:R:Q165	7.6075	4	3	6
23	R:R:M174	6.2	4	1	1
24	R:R:R177	6.5425	4	1	2
25	R:R:W184	8.816	5	0	5
26	R:R:K194	3.3375	4	0	3
27	R:R:Y196	8.7525	4	0	6
28	R:R:Y205	6.125	4	0	8
29	R:R:Y216	6.23833	6	6	9
30	R:R:M249	2.555	4	0	8
31	R:R:M250	5.85	4	0	8
32	R:R:W261	7.0275	4	7	8
33	R:R:F264	8.1275	4	7	7
34	R:R:F267	6.014	5	8	4
35	R:R:Y278	7.28	4	8	2
36	R:R:Q284	9.195	4	1	4
37	R:R:Y287	5.90667	6	0	5
38	R:R:W292	5.0375	4	0	5
39	R:R:F312	4.415	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F7	R:R:F25	12.8979	8.57	Yes	Yes	1	0	6
2	R:R:F25	R:R:R177	11.8065	6.41	Yes	Yes	1	6	2
3	R:R:R177	R:R:V179	11.9543	3.92	Yes	No	1	2	3
4	L:L:F7	R:R:N96	26.2108	8.46	Yes	Yes	1	0	4
5	R:R:N96	R:R:R177	11.9088	9.64	Yes	Yes	1	4	2
6	L:L:F7	R:R:Y287	56.736	10.32	Yes	Yes	0	0	5
7	R:R:N96	R:R:Y92	19.4804	5.81	Yes	No	0	4	4
8	R:R:F267	R:R:Y287	47.1635	7.22	Yes	Yes	0	4	5
9	R:R:F267	R:R:F268	25.7958	5.36	Yes	No	0	4	6
10	L:L:M11	R:R:F268	41.0698	11.2	No	No	0	0	6
11	L:L:M11	R:R:I113	12.6194	4.37	No	Yes	3	0	5
12	L:L:M11	R:R:Q165	27.5125	5.44	No	Yes	3	0	6
13	R:R:N89	R:R:Y287	16.8031	4.65	Yes	Yes	0	6	5
14	R:R:Q27	R:R:Q284	22.0214	12.8	No	Yes	0	4	4
15	R:R:Q27	R:R:Q285	20.5434	7.68	No	No	0	4	1
16	R:R:Q285	R:R:W35	12.6648	4.38	No	Yes	4	1	4
17	R:R:L288	R:R:W35	14.8079	12.53	No	Yes	0	3	4
18	R:R:L288	R:R:Y39	14.5123	4.69	No	No	0	3	7
19	R:R:F90	R:R:Y39	15.6264	18.57	No	No	0	6	7
20	R:R:F90	R:R:V94	11.7156	7.87	No	No	0	6	5
21	R:R:W292	R:R:Y39	16.0528	6.75	Yes	No	0	5	7
22	R:R:M291	R:R:Y287	43.4629	4.79	No	Yes	0	5	5
23	R:R:M291	R:R:M295	64.859	4.33	No	No	0	5	7
24	R:R:M295	R:R:M81	64.3986	5.78	No	Yes	0	7	7
25	R:R:M81	R:R:T298	31.5086	3.01	Yes	No	0	7	9
26	R:R:M299	R:R:T298	25	3.01	No	No	0	7	9
27	R:R:I42	R:R:M299	22.3397	4.37	No	No	0	7	7
28	R:R:I42	R:R:W292	21.1005	5.87	No	Yes	0	7	5
29	R:R:E78	R:R:M81	67.5932	6.77	Yes	Yes	0	9	7
30	R:R:E78	R:R:L74	65.4616	5.3	Yes	Yes	0	9	9
31	R:R:L74	R:R:S122	64.3645	7.51	Yes	No	0	9	8
32	R:R:N73	R:R:S122	64.3076	4.47	No	No	0	9	8
33	R:R:I151	R:R:N73	100	9.91	No	No	0	8	9
34	R:R:F70	R:R:I151	99.2838	5.02	Yes	No	0	7	8
35	R:R:F70	R:R:T147	97.0441	3.89	Yes	No	0	7	7
36	R:R:R141	R:R:T147	93.8552	3.88	No	No	0	5	7
37	R:R:R141	R:R:T67	91.462	5.17	No	No	0	5	8
38	R:R:N68	R:R:T67	89.7738	7.31	No	No	0	8	8
39	R:R:M63	R:R:N68	88.8358	7.01	No	No	0	7	8
40	R:R:M63	R:R:R311	88.0457	6.2	No	No	0	7	6
41	R:R:N309	R:R:R311	87.3067	13.26	No	No	0	8	6
42	R:R:F312	R:R:N309	86.4086	7.25	Yes	No	0	9	8
43	R:R:F312	R:R:I57	20.4411	3.77	Yes	No	0	9	7
44	R:R:I57	R:R:V53	12.7615	3.07	No	No	0	7	8
45	R:R:F312	R:R:I56	20.5548	2.51	Yes	Yes	0	9	8
46	R:R:I56	R:R:W55	14.3986	3.52	Yes	Yes	0	8	4
47	R:R:F312	R:R:Y305	57.907	4.13	Yes	No	0	9	9
48	R:R:N85	R:R:P112	11.0505	4.89	No	No	0	6	6
49	R:R:F111	R:R:P112	10.7208	5.78	Yes	No	0	4	6
50	R:R:F111	R:R:S80	21.055	5.28	Yes	No	0	4	6
51	R:R:F76	R:R:S80	20.8163	7.93	No	No	0	6	6
52	R:R:F76	R:R:W155	21.271	5.01	No	No	0	6	9
53	R:R:W98	R:R:Y92	18.8438	13.5	Yes	No	0	8	4
54	R:R:W98	R:R:Y100	12.8411	16.4	Yes	Yes	0	8	7
55	R:R:Y100	R:R:Y104	13.4322	7.94	Yes	No	0	7	5
56	R:R:F107	R:R:Y104	13.0059	6.19	No	No	0	4	5
57	R:R:F107	R:R:F111	13.2049	6.43	No	Yes	0	4	4
58	R:R:C105	R:R:W98	14.1826	3.92	Yes	Yes	5	9	8
59	R:R:Q165	R:R:Y196	16.7235	11.27	Yes	Yes	0	6	6
60	R:R:P164	R:R:Y196	17.525	5.56	No	Yes	0	8	6
61	R:R:F163	R:R:P164	17.0816	4.33	No	No	0	4	8
62	R:R:F110	R:R:F163	24.8238	5.36	No	No	0	6	4
63	R:R:F110	R:R:L159	24.5964	6.09	No	No	0	6	4
64	R:R:F117	R:R:I113	10.357	5.02	Yes	Yes	0	7	5
65	R:R:A118	R:R:W155	26.8361	7.78	No	No	0	7	9
66	R:R:A118	R:R:A158	25.8527	1.79	No	No	0	7	8
67	R:R:A114	R:R:A158	25.1137	1.79	No	No	0	5	8
68	R:R:A114	R:R:L159	24.7044	4.73	No	No	0	5	4
69	R:R:F117	R:R:I204	11.4427	15.07	Yes	No	0	7	6
70	R:R:R130	R:R:Y305	55.4286	4.12	Yes	No	0	9	9
71	R:R:R130	R:R:Y216	50.6594	3.09	Yes	Yes	0	9	9
72	R:R:M250	R:R:Y216	36.5052	15.57	Yes	Yes	0	8	9
73	R:R:M250	R:R:V219	25.3354	4.56	Yes	No	0	8	8
74	R:R:V219	R:R:Y131	19.2985	2.52	No	Yes	0	8	8
75	R:R:I135	R:R:Y131	13.0457	7.25	No	Yes	0	7	8
76	R:R:I182	R:R:Q165	12.0566	5.49	No	Yes	0	4	6
77	R:R:I182	R:R:W184	11.3063	9.4	No	Yes	0	4	5
78	R:R:W184	R:R:Y168	13.9154	4.82	Yes	No	0	5	5
79	R:R:Y167	R:R:Y168	10.5787	12.91	No	No	0	4	5
80	R:R:W184	R:R:Y196	19.6567	10.61	Yes	Yes	0	5	6
81	R:R:F267	R:R:Y278	20.4411	6.19	Yes	Yes	8	4	2
82	R:R:P271	R:R:Y278	12.4318	9.74	No	Yes	0	4	2
83	R:R:P271	R:R:Y272	11.4484	4.17	No	No	0	4	5
84	R:R:E193	R:R:W184	10.8799	16.36	No	Yes	0	4	5
85	R:R:W184	R:R:Y192	30.008	2.89	Yes	No	0	5	4
86	R:R:H187	R:R:Y192	26.8702	7.62	No	No	0	2	4
87	R:R:H187	R:R:I191	20.2194	7.95	No	No	0	2	1
88	R:R:I191	R:R:K194	16.877	2.91	No	Yes	0	1	3
89	R:R:F264	R:R:M291	37.8638	6.22	Yes	No	0	7	5
90	R:R:F264	R:R:W261	23.9427	10.02	Yes	Yes	7	7	8
91	R:R:F257	R:R:W261	21.2483	8.02	No	Yes	0	9	8
92	R:R:F257	R:R:L209	12.7558	7.31	No	No	0	9	6
93	R:R:L209	R:R:Y205	10.6298	4.69	No	Yes	0	6	8
94	L:L:F7	R:R:Q284	23.0048	7.03	Yes	Yes	1	0	4
95	R:R:N73	R:R:W155	42.4625	7.91	No	No	0	9	9
96	R:R:F264	R:R:F268	19.7703	10.72	Yes	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F7	R:R:F25	8.57	1	Yes	Yes	0	6	0	1
L:L:F7	R:R:N96	8.46	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:Q284	7.03	1	Yes	Yes	0	4	0	1
L:L:F7	R:R:Y287	10.32	1	Yes	Yes	0	5	0	1
L:L:F8	R:R:V179	6.55	0	No	No	0	3	0	1
L:L:F8	R:R:M181	7.46	0	No	No	0	4	0	1
L:L:G9	R:R:Y287	5.79	0	No	Yes	0	5	0	1
L:L:L10	R:R:Y92	4.69	0	No	No	0	4	0	1
L:L:L10	R:R:H108	5.14	0	No	Yes	0	5	0	1
L:L:M11	R:R:I113	4.37	3	No	Yes	0	5	0	1
L:L:M11	R:R:Q165	5.44	3	No	Yes	0	6	0	1
L:L:M11	R:R:F268	11.2	3	No	No	0	6	0	1
L:L:?12	R:R:N85	10.2	2	No	No	0	6	0	1
L:L:?12	R:R:N89	10.2	2	No	Yes	0	6	0	1
L:L:?12	R:R:H108	9.55	2	No	Yes	0	5	0	1
R:R:F25	R:R:Q24	10.54	1	Yes	No	6	3	1	2
R:R:K281	R:R:Q24	8.14	0	No	No	2	3	2	2
R:R:F25	R:R:N96	4.83	1	Yes	Yes	6	4	1	1
R:R:F25	R:R:R177	6.41	1	Yes	Yes	6	2	1	2
R:R:F25	R:R:Q284	12.88	1	Yes	Yes	6	4	1	1
R:R:Q27	R:R:Q284	12.8	0	No	Yes	4	4	2	1
R:R:N85	R:R:N89	9.54	2	No	Yes	6	6	1	1
R:R:N85	R:R:P112	4.89	2	No	No	6	6	1	2
R:R:H108	R:R:V88	9.69	2	Yes	No	5	5	1	2
R:R:H108	R:R:N89	8.93	2	Yes	Yes	5	6	1	1
R:R:N89	R:R:Y287	4.65	2	Yes	Yes	6	5	1	1
R:R:N96	R:R:Y92	5.81	1	Yes	No	4	4	1	1
R:R:W98	R:R:Y92	13.5	5	Yes	No	8	4	2	1
R:R:N96	R:R:R177	9.64	1	Yes	Yes	4	2	1	2
R:R:F117	R:R:I113	5.02	0	Yes	Yes	7	5	2	1
R:R:I113	R:R:Q165	8.23	3	Yes	Yes	5	6	1	1
R:R:I182	R:R:Q165	5.49	0	No	Yes	4	6	2	1
R:R:Q165	R:R:Y196	11.27	3	Yes	Yes	6	6	1	2
R:R:M174	R:R:R177	6.2	1	Yes	Yes	1	2	2	2
R:R:M174	R:R:V179	6.09	1	Yes	No	1	3	2	1
R:R:R177	R:R:V179	3.92	1	Yes	No	2	3	2	1
R:R:F264	R:R:F268	10.72	7	Yes	No	7	6	2	1
R:R:F264	R:R:M291	6.22	7	Yes	No	7	5	2	2
R:R:F267	R:R:F268	5.36	8	Yes	No	4	6	2	1
R:R:F267	R:R:Y287	7.22	8	Yes	Yes	4	5	2	1
R:R:K281	R:R:Q284	4.07	0	No	Yes	2	4	2	1
R:R:M291	R:R:Y287	4.79	0	No	Yes	5	5	2	1
R:R:A162	R:R:I113	3.25	0	No	Yes	7	5	2	1
R:R:A93	R:R:Y287	2.67	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RMI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.88
Number of Linked Nodes	272
Number of Links	290
Number of Hubs	39
Number of Links mediated by Hubs	138
Number of Communities	8
Number of Nodes involved in Communities	29
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	41744
Length Of Smallest Path	3
Average Path Length	16.4924
Length of Longest Path	37
Minimum Path Strength	1.365
Average Path Strength	6.4534
Maximum Path Strength	15.385
Minimum Path Correlation	0.7
Average Path Correlation	0.923273
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	43.2628
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.5722
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Substance-P
UniProt	P20366
Sequence	>7RMI_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P25103
Sequence	>7RMI_nogp_Chain_R N Q F V Q P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H K R M R T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N E W Y Y G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H P L Q P R L S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S T T E T M P S R V V C M I E W P E H P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N P D L Y L K K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F R L G F K H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6E59	A	Peptide	Tachykinin	NK₁	Homo sapiens	L-760735	-	-	3.4	2018-12-12	doi.org/10.1073/pnas.1812717115
	6HLL	A	Peptide	Tachykinin	NK₁	Homo sapiens	CP99994	-	-	3.27	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLO	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.4	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLP	A	Peptide	Tachykinin	NK₁	Homo sapiens	Netupitant	-	-	2.2	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6J20	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.7	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	6J21	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	3.2	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	7RMG	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMG (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7P00	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P00 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs)/β1/γ2	2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	8U26	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	8U26 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7RMI_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.