psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R1	R:R:E172	8.14	No	No	0	0	3
2	L:L:R1	R:R:E183	4.65	No	No	0	0	3
3	L:L:P2	L:L:Q6	4.74	No	No	4	0	0
4	L:L:F8	L:L:P2	4.33	Yes	No	4	0	0
5	L:L:K3	L:L:Q6	12.2	No	No	0	0	0
6	L:L:K3	R:R:L279	4.23	No	No	0	0	2
7	L:L:P4	L:L:Q5	11.05	No	No	0	0	0
8	L:L:Q5	R:R:Q24	7.68	No	No	0	0	3
9	L:L:F8	L:L:Q6	12.88	Yes	No	4	0	0
10	L:L:F7	L:L:G9	3.01	Yes	No	0	0	0
11	L:L:F7	R:R:F25	9.65	Yes	Yes	2	0	6
12	L:L:F7	R:R:N96	8.46	Yes	Yes	2	0	4
13	L:L:F7	R:R:Q284	8.2	Yes	Yes	2	0	4
14	L:L:F7	R:R:Y287	9.28	Yes	Yes	0	0	5
15	L:L:F8	R:R:Y92	3.09	Yes	Yes	0	0	4
16	L:L:F8	R:R:V179	7.87	Yes	No	0	0	3
17	L:L:?12	L:L:L10	3.43	Yes	No	0	0	0
18	L:L:L10	R:R:Y92	4.69	No	Yes	0	0	4
19	L:L:?12	L:L:M11	3.5	Yes	Yes	1	0	0
20	L:L:M11	R:R:I113	4.37	Yes	Yes	1	0	5
21	L:L:M11	R:R:Q165	4.08	Yes	No	1	0	6
22	L:L:M11	R:R:F268	8.71	Yes	No	0	0	6
23	L:L:?12	R:R:N85	10.2	Yes	No	1	0	6
24	L:L:?12	R:R:N89	10.2	Yes	Yes	1	0	6
25	L:L:?12	R:R:H108	6.36	Yes	No	1	0	5
26	R:R:N23	R:R:R177	8.44	No	Yes	0	8	2
27	R:R:F25	R:R:Q24	8.2	Yes	No	0	6	3
28	R:R:F25	R:R:N96	10.87	Yes	Yes	2	6	4
29	R:R:F25	R:R:R177	5.34	Yes	Yes	2	6	2
30	R:R:F25	R:R:Q284	7.03	Yes	Yes	2	6	4
31	R:R:H95	R:R:V26	5.54	No	No	0	5	1
32	R:R:I32	R:R:Q27	5.49	No	No	0	3	4
33	R:R:Q27	R:R:Q284	7.68	No	Yes	0	4	4
34	R:R:P28	R:R:W30	5.4	No	No	5	2	1
35	R:R:P28	R:R:Q31	7.9	No	No	5	2	2
36	R:R:Q31	R:R:W30	15.33	No	No	5	2	1
37	R:R:Q285	R:R:Q31	3.84	No	No	0	1	2
38	R:R:I32	R:R:V94	4.61	No	No	0	3	5
39	R:R:Q285	R:R:W35	3.29	No	No	0	1	4
40	R:R:L288	R:R:W35	10.25	No	No	0	3	4
41	R:R:F90	R:R:Y39	12.38	No	Yes	0	6	7
42	R:R:L288	R:R:Y39	4.69	No	Yes	0	3	7
43	R:R:M291	R:R:Y39	3.59	No	Yes	0	5	7
44	R:R:W292	R:R:Y39	7.72	Yes	Yes	0	5	7
45	R:R:I42	R:R:W292	7.05	No	Yes	0	7	5
46	R:R:T86	R:R:V43	3.17	No	No	0	7	6
47	R:R:M299	R:R:T45	7.53	No	No	0	7	4
48	R:R:A82	R:R:S46	3.42	No	No	0	6	8
49	R:R:S46	R:R:T298	7.99	No	No	0	8	9
50	R:R:M299	R:R:S46	3.07	No	No	0	7	8
51	R:R:G49	R:R:V48	3.68	No	No	0	8	4
52	R:R:G49	R:R:P302	4.06	No	No	0	8	9
53	R:R:E78	R:R:N50	9.2	Yes	No	0	9	9
54	R:R:I56	R:R:V52	3.07	Yes	No	3	8	6
55	R:R:F316	R:R:V52	5.24	Yes	No	3	6	6
56	R:R:P302	R:R:V53	3.53	No	No	0	9	8
57	R:R:I56	R:R:W55	3.52	Yes	Yes	3	8	4
58	R:R:A59	R:R:W55	7.78	No	Yes	0	4	4
59	R:R:H60	R:R:W55	5.29	No	Yes	3	5	4
60	R:R:H60	R:R:I56	6.63	No	Yes	3	5	8
61	R:R:F312	R:R:I56	3.77	Yes	Yes	0	9	8
62	R:R:G315	R:R:I56	5.29	No	Yes	0	6	8
63	R:R:F316	R:R:I56	3.77	Yes	Yes	3	6	8
64	R:R:I57	R:R:N68	5.66	No	No	0	7	8
65	R:R:I57	R:R:V72	6.14	No	No	0	7	6
66	R:R:F312	R:R:I57	5.02	Yes	No	0	9	7
67	R:R:H60	R:R:R311	6.77	No	No	0	5	6
68	R:R:K61	R:R:R64	6.19	No	No	0	6	6
69	R:R:M63	R:R:R311	13.65	No	No	0	7	6
70	R:R:T65	R:R:T67	3.14	No	No	7	7	8
71	R:R:R141	R:R:V66	6.54	Yes	No	0	5	6
72	R:R:T147	R:R:Y69	4.99	No	No	0	7	5
73	R:R:A125	R:R:F70	5.55	No	Yes	0	7	7
74	R:R:D129	R:R:F70	8.36	No	Yes	0	9	7
75	R:R:F70	R:R:T147	3.89	Yes	No	0	7	7
76	R:R:F70	R:R:V150	3.93	Yes	No	0	7	5
77	R:R:F70	R:R:I151	5.02	Yes	No	0	7	8
78	R:R:L71	R:R:Y305	9.38	No	No	0	8	9
79	R:R:N73	R:R:S122	8.94	No	No	0	9	8
80	R:R:I151	R:R:N73	5.66	No	No	0	8	9
81	R:R:N73	R:R:W155	5.65	No	No	0	9	9
82	R:R:E78	R:R:L74	6.63	Yes	No	6	9	9
83	R:R:L74	R:R:S119	3	No	No	6	9	9
84	R:R:L74	R:R:S122	3	No	No	0	9	8
85	R:R:F76	R:R:S80	7.93	No	No	0	6	6
86	R:R:E78	R:R:S119	5.75	Yes	No	6	9	9
87	R:R:E78	R:R:T298	7.06	Yes	No	0	9	9
88	R:R:E78	R:R:N301	6.57	Yes	No	0	9	9
89	R:R:M81	R:R:V116	4.56	No	No	0	7	7
90	R:R:M81	R:R:S119	3.07	No	No	0	7	9
91	R:R:M295	R:R:M81	4.33	No	No	0	7	7
92	R:R:N85	R:R:N89	5.45	No	Yes	1	6	6
93	R:R:N85	R:R:P112	6.52	No	No	0	6	6
94	R:R:M295	R:R:T86	7.53	No	No	0	7	7
95	R:R:T91	R:R:V88	3.17	No	Yes	1	4	5
96	R:R:V88	R:R:Y100	5.05	Yes	Yes	1	5	7
97	R:R:V88	R:R:Y104	5.05	Yes	No	1	5	5
98	R:R:H108	R:R:V88	8.3	No	Yes	1	5	5
99	R:R:H108	R:R:N89	10.2	No	Yes	1	5	6
100	R:R:N89	R:R:Y287	4.65	Yes	Yes	0	6	5
101	R:R:F90	R:R:V94	7.87	No	No	0	6	5
102	R:R:T91	R:R:Y100	6.24	No	Yes	1	4	7
103	R:R:N96	R:R:Y92	3.49	Yes	Yes	0	4	4
104	R:R:W98	R:R:Y92	8.68	Yes	Yes	0	8	4
105	R:R:A93	R:R:L288	3.15	No	No	0	5	3
106	R:R:H95	R:R:V94	5.54	No	No	0	5	5
107	R:R:H95	R:R:Y99	3.27	No	No	0	5	2
108	R:R:N96	R:R:R177	8.44	Yes	Yes	2	4	2
109	R:R:E97	R:R:Y99	8.98	No	No	0	4	2
110	R:R:W98	R:R:Y100	13.5	Yes	Yes	1	8	7
111	R:R:C105	R:R:W98	3.92	Yes	Yes	1	9	8
112	R:R:C180	R:R:W98	6.53	No	Yes	1	9	8
113	R:R:Y100	R:R:Y104	5.96	Yes	No	1	7	5
114	R:R:L102	R:R:T171	4.42	No	No	0	3	5
115	R:R:C105	R:R:S169	5.16	Yes	Yes	1	9	5
116	R:R:C105	R:R:T171	3.38	Yes	No	0	9	5
117	R:R:C105	R:R:C180	7.28	Yes	No	1	9	9
118	R:R:F107	R:R:F111	6.43	No	No	0	4	4
119	R:R:N109	R:R:S169	8.94	No	Yes	1	5	5
120	R:R:I182	R:R:N109	7.08	No	No	1	4	5
121	R:R:F110	R:R:L159	3.65	No	No	0	6	4
122	R:R:F110	R:R:F163	3.22	No	No	0	6	4
123	R:R:F111	R:R:P112	5.78	No	No	0	4	6
124	R:R:F117	R:R:I113	3.77	No	Yes	0	7	5
125	R:R:A162	R:R:I113	3.25	No	Yes	0	7	5
126	R:R:I113	R:R:Q165	4.12	Yes	No	1	5	6
127	R:R:A114	R:R:L159	3.15	No	No	0	5	4
128	R:R:F117	R:R:L161	9.74	No	No	0	7	5
129	R:R:F117	R:R:I204	6.28	No	No	0	7	6
130	R:R:A118	R:R:W155	9.08	No	No	0	7	9
131	R:R:I154	R:R:Y121	3.63	No	No	0	7	5
132	R:R:P208	R:R:T124	6.99	No	No	0	9	7
133	R:R:T124	R:R:V211	3.17	No	No	0	7	6
134	R:R:R130	R:R:V126	6.54	No	No	0	9	9
135	R:R:A127	R:R:Y216	4	No	Yes	0	9	9
136	R:R:D129	R:R:F128	4.78	No	No	0	9	5
137	R:R:F128	R:R:M132	3.73	No	No	0	5	5
138	R:R:D129	R:R:R141	10.72	No	Yes	0	9	5
139	R:R:R130	R:R:Y216	7.2	No	Yes	0	9	9
140	R:R:R130	R:R:Y305	3.09	No	No	0	9	9
141	R:R:I135	R:R:Y131	9.67	Yes	No	8	7	8
142	R:R:A215	R:R:Y131	4	No	No	0	7	8
143	R:R:V218	R:R:Y131	3.79	No	No	8	4	8
144	R:R:H136	R:R:M132	3.94	Yes	No	0	6	5
145	R:R:I134	R:R:V219	6.14	No	No	0	8	8
146	R:R:H136	R:R:I135	5.3	Yes	Yes	0	6	7
147	R:R:I135	R:R:V218	3.07	Yes	No	8	7	4
148	R:R:I135	R:R:V219	3.07	Yes	No	0	7	8
149	R:R:I135	R:R:T222	4.56	Yes	No	0	7	5
150	R:R:L142	R:R:R141	3.64	No	Yes	0	6	5
151	R:R:R141	R:R:T147	3.88	Yes	No	0	5	7
152	R:R:L161	R:R:L203	4.15	No	No	0	5	4
153	R:R:F163	R:R:P164	5.78	No	No	0	4	8
154	R:R:F163	R:R:Y167	5.16	No	No	0	4	4
155	R:R:Q165	R:R:Y196	11.27	No	No	0	6	6
156	R:R:Y167	R:R:Y168	5.96	No	No	0	4	5
157	R:R:W184	R:R:Y168	3.86	Yes	No	1	5	5
158	R:R:P185	R:R:Y168	16.69	No	No	1	4	5
159	R:R:I182	R:R:S169	3.1	No	Yes	1	4	5
160	R:R:M181	R:R:T170	3.01	No	No	0	4	4
161	R:R:E172	R:R:M181	5.41	No	No	0	3	4
162	R:R:M174	R:R:P175	3.35	No	No	0	1	2
163	R:R:R177	R:R:V179	3.92	Yes	No	0	2	3
164	R:R:I182	R:R:W184	9.4	No	Yes	1	4	5
165	R:R:E183	R:R:E186	3.81	No	No	0	3	3
166	R:R:P185	R:R:W184	5.4	No	Yes	1	4	5
167	R:R:E193	R:R:W184	11.99	No	Yes	0	4	5
168	R:R:W184	R:R:Y196	6.75	Yes	No	0	5	6
169	R:R:H187	R:R:P188	13.73	No	No	0	2	1
170	R:R:H187	R:R:I191	6.63	No	No	0	2	1
171	R:R:H187	R:R:Y192	10.89	No	No	0	2	4
172	R:R:E193	R:R:K190	6.75	No	No	0	4	2
173	R:R:E193	R:R:Y272	12.35	No	No	0	4	5
174	R:R:K194	R:R:Y272	10.75	No	No	0	3	5
175	R:R:H197	R:R:Y272	10.89	No	No	0	5	5
176	R:R:I204	R:R:V200	3.07	No	No	0	6	5
177	R:R:H265	R:R:T201	5.48	No	No	0	7	6
178	R:R:L269	R:R:T201	7.37	No	No	0	5	6
179	R:R:H265	R:R:I204	9.28	No	No	0	7	6
180	R:R:F206	R:R:Y205	4.13	No	No	0	4	8
181	R:R:L262	R:R:Y205	7.03	No	No	0	5	8
182	R:R:H265	R:R:Y205	5.44	No	No	0	7	8
183	R:R:F257	R:R:L209	3.65	No	No	0	9	6
184	R:R:V218	R:R:Y214	6.31	No	No	0	4	4
185	R:R:M250	R:R:Y216	20.35	Yes	Yes	0	8	9
186	R:R:M250	R:R:V219	4.56	Yes	No	0	8	8
187	R:R:G220	R:R:V247	3.68	No	No	0	5	6
188	R:R:R244	R:R:W224	13.99	No	No	0	5	4
189	R:R:V247	R:R:W224	6.13	No	No	0	6	4
190	R:R:R244	R:R:V240	6.54	No	No	0	5	2
191	R:R:K245	R:R:L308	4.23	No	No	0	8	7
192	R:R:M250	R:R:V246	3.04	Yes	No	0	8	7
193	R:R:I251	R:R:K248	7.27	No	No	0	5	6
194	R:R:K248	R:R:V252	7.59	No	No	0	6	5
195	R:R:I304	R:R:M249	4.37	No	Yes	0	8	8
196	R:R:T256	R:R:Y300	6.24	No	No	0	6	5
197	R:R:F257	R:R:W261	8.02	No	No	0	9	8
198	R:R:F264	R:R:W261	6.01	No	No	0	7	8
199	R:R:L262	R:R:P263	3.28	No	No	0	5	9
200	R:R:I266	R:R:L262	7.14	No	No	0	6	5
201	R:R:I290	R:R:P263	3.39	No	No	0	6	9
202	R:R:L293	R:R:P263	3.28	No	No	0	7	9
203	R:R:F264	R:R:F268	12.86	No	No	0	7	6
204	R:R:A294	R:R:F264	5.55	No	No	0	7	7
205	R:R:F267	R:R:F268	3.22	Yes	No	0	4	6
206	R:R:F267	R:R:Y278	10.32	Yes	No	9	4	2
207	R:R:F267	R:R:I283	5.02	Yes	No	9	4	4
208	R:R:F267	R:R:Y287	7.22	Yes	Yes	0	4	5
209	R:R:F267	R:R:I290	5.02	Yes	No	0	4	6
210	R:R:P271	R:R:Y278	11.13	No	No	0	4	2
211	R:R:N274	R:R:P275	3.26	No	No	0	4	3
212	R:R:I283	R:R:Y278	4.84	No	No	9	4	2
213	R:R:F282	R:R:V286	5.24	No	No	0	3	5
214	R:R:I283	R:R:V286	3.07	No	No	0	4	5
215	R:R:M291	R:R:Y287	3.59	No	Yes	0	5	5
216	R:R:M291	R:R:M295	4.33	No	No	0	5	7
217	R:R:S296	R:R:Y300	3.82	No	No	0	5	5
218	R:R:F312	R:R:Y305	3.09	Yes	No	0	9	9
219	R:R:C306	R:R:F316	4.19	No	Yes	0	7	6
220	R:R:F312	R:R:N309	3.62	Yes	No	0	9	8
221	R:R:D310	R:R:R313	3.57	No	No	0	4	8
222	R:R:K317	R:R:L314	4.23	No	No	0	5	4
223	R:R:N23	R:R:S176	2.98	No	No	0	8	5
224	R:R:L157	R:R:V153	2.98	No	No	0	4	3
225	R:R:L223	R:R:V246	2.98	No	No	0	8	7
226	R:R:N68	R:R:T65	2.92	No	No	7	8	7
227	R:R:N68	R:R:T67	2.92	No	No	7	8	8
228	R:R:I212	R:R:M123	2.92	No	No	0	8	8
229	R:R:M249	R:R:M250	2.89	Yes	Yes	0	8	8
230	L:L:P2	L:L:R1	2.88	No	No	0	0	0
231	R:R:I191	R:R:N189	2.83	No	No	0	1	3
232	R:R:L308	R:R:M249	2.83	No	Yes	0	7	8
233	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
234	R:R:A36	R:R:F90	2.77	No	No	0	6	6
235	R:R:A83	R:R:F84	2.77	No	No	0	4	5
236	R:R:L270	R:R:L277	2.77	No	No	0	4	5
237	R:R:K281	R:R:Q284	2.71	No	Yes	0	2	4
238	R:R:C260	R:R:Y300	2.69	No	No	0	8	5
239	R:R:D310	R:R:N309	2.69	No	No	0	4	8
240	R:R:F111	R:R:S80	2.64	No	No	0	4	6
241	R:R:F312	R:R:V53	2.62	Yes	No	0	9	8
242	R:R:F316	R:R:V53	2.62	Yes	No	0	6	8
243	R:R:A38	R:R:W292	2.59	No	Yes	0	4	5
244	R:R:A319	R:R:W55	2.59	No	Yes	0	4	4
245	L:L:F8	R:R:M174	2.49	Yes	No	0	0	1
246	R:R:S297	R:R:W261	2.47	No	No	0	9	8
247	R:R:S296	R:R:W292	2.47	No	Yes	0	5	5
248	R:R:L58	R:R:R64	2.43	No	No	0	2	6
249	R:R:I212	R:R:Y216	2.42	No	Yes	0	8	9
250	R:R:L203	R:R:Y121	2.34	No	No	0	4	5
251	R:R:F84	R:R:Y104	2.06	No	No	0	5	5
252	R:R:G166	R:R:S169	1.86	No	Yes	0	5	5
253	R:R:G213	R:R:T217	1.82	No	No	0	4	3
254	R:R:A118	R:R:A77	1.79	No	No	0	7	8
255	R:R:A114	R:R:A158	1.79	No	No	0	5	8
256	R:R:A118	R:R:A158	1.79	No	No	0	7	8
257	R:R:A115	R:R:S80	1.71	No	No	0	8	6
258	R:R:C152	R:R:V156	1.71	No	No	0	3	3
259	R:R:C199	R:R:V195	1.71	No	No	0	4	4
260	R:R:A82	R:R:V47	1.7	No	No	0	6	6
261	R:R:A79	R:R:V51	1.7	No	No	0	7	4
262	R:R:A144	R:R:V66	1.7	No	No	0	2	6
263	R:R:I120	R:R:P208	1.69	No	No	0	7	9
264	R:R:L207	R:R:P208	1.64	No	No	0	5	9
265	R:R:C255	R:R:I251	1.64	No	No	0	4	5
266	R:R:L270	R:R:P271	1.64	No	No	0	4	4
267	R:R:A75	R:R:M54	1.61	No	No	0	9	7
268	R:R:V43	R:R:V87	1.6	No	No	0	6	8
269	R:R:S143	R:R:T145	1.6	No	No	0	7	4
270	R:R:V149	R:R:V153	1.6	No	No	0	3	3
271	R:R:T40	R:R:V44	1.59	No	No	0	4	4
272	R:R:T45	R:R:V41	1.59	No	No	0	4	5
273	R:R:T171	R:R:V178	1.59	No	No	0	5	4
274	R:R:T173	R:R:V178	1.59	No	No	0	2	4
275	R:R:T256	R:R:V252	1.59	No	No	0	6	5
276	R:R:C307	R:R:L308	1.59	No	No	0	6	7
277	R:R:P140	R:R:Q139	1.58	No	No	0	6	4
278	R:R:A146	R:R:L142	1.58	No	No	0	4	6
279	R:R:A258	R:R:L209	1.58	No	No	0	5	6
280	R:R:A75	R:R:N50	1.56	No	No	0	9	9
281	R:R:A79	R:R:N50	1.56	No	No	0	7	9
282	R:R:I120	R:R:V116	1.54	No	No	0	7	7
283	R:R:I191	R:R:V195	1.54	No	No	0	1	4
284	R:R:I212	R:R:V254	1.54	No	No	0	8	8
285	R:R:I251	R:R:V247	1.54	No	No	0	5	6
286	R:R:H136	R:R:P137	1.53	Yes	No	0	6	8
287	R:R:I221	R:R:T217	1.52	No	No	0	3	3
288	R:R:M249	R:R:V253	1.52	Yes	No	0	8	7
289	R:R:I198	R:R:L269	1.43	No	No	0	5	5
290	R:R:I273	R:R:L270	1.43	No	No	0	5	4
291	R:R:I273	R:R:N274	1.42	No	No	0	5	4
292	R:R:L58	R:R:M54	1.41	No	No	0	2	7
293	R:R:K243	R:R:L223	1.41	No	No	0	7	8
294	R:R:D276	R:R:L279	1.36	No	No	0	1	2
295	R:R:D310	R:R:L314	1.36	No	No	0	4	4
296	R:R:A289	R:R:W35	1.3	No	No	0	5	4
297	R:R:H136	R:R:Q139	1.24	Yes	No	0	6	4
298	R:R:K148	R:R:Y69	1.19	No	No	0	2	5
299	R:R:L34	R:R:W30	1.14	No	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F7	7.72	5	2	0
2	L:L:F8	6.132	5	4	0
3	L:L:M11	5.165	4	1	0
4	L:L:?12	6.738	5	1	0
5	R:R:F25	8.218	5	2	6
6	R:R:Y39	7.095	4	0	7
7	R:R:W55	4.795	4	3	4
8	R:R:I56	4.34167	6	3	8
9	R:R:F70	5.35	5	0	7
10	R:R:E78	7.042	5	6	9
11	R:R:V88	5.3925	4	1	5
12	R:R:N89	7.625	4	1	6
13	R:R:Y92	4.9875	4	0	4
14	R:R:N96	7.815	4	2	4
15	R:R:W98	7.088	5	1	8
16	R:R:Y100	7.6875	4	1	7
17	R:R:C105	4.935	4	1	9
18	R:R:I113	3.8775	4	1	5
19	R:R:I135	5.134	5	8	7
20	R:R:H136	3.0025	4	0	6
21	R:R:R141	6.195	4	0	5
22	R:R:S169	4.765	4	1	5
23	R:R:R177	6.535	4	2	2
24	R:R:W184	7.48	5	1	5
25	R:R:Y216	8.4925	4	0	9
26	R:R:M249	2.9025	4	0	8
27	R:R:M250	7.71	4	0	8
28	R:R:F267	6.16	5	9	4
29	R:R:Q284	6.405	4	2	4
30	R:R:Y287	6.185	4	0	5
31	R:R:W292	4.9575	4	0	5
32	R:R:F312	3.624	5	0	9
33	R:R:F316	3.955	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F8	L:L:P2	10.623	4.33	Yes	No	4	0	0
2	R:R:N96	R:R:Y92	29.1163	3.49	Yes	Yes	0	4	4
3	L:L:F8	R:R:Y92	20.2966	3.09	Yes	Yes	0	0	4
4	L:L:F7	R:R:N96	29.7006	8.46	Yes	Yes	2	0	4
5	L:L:F7	R:R:Y287	42.8234	9.28	Yes	Yes	0	0	5
6	L:L:?12	L:L:M11	22.2403	3.5	Yes	Yes	1	0	0
7	L:L:M11	R:R:I113	21.0831	4.37	Yes	Yes	1	0	5
8	L:L:M11	R:R:Q165	15.8025	4.08	Yes	No	1	0	6
9	L:L:M11	R:R:F268	20.5494	8.71	Yes	No	0	0	6
10	L:L:?12	R:R:N89	16.8305	10.2	Yes	Yes	1	0	6
11	R:R:M291	R:R:Y287	100	3.59	No	Yes	0	5	5
12	R:R:M291	R:R:Y39	47.0985	3.59	No	Yes	0	5	7
13	R:R:L288	R:R:Y39	14.1902	4.69	No	Yes	0	3	7
14	R:R:L288	R:R:W35	11.1511	10.25	No	No	0	3	4
15	R:R:F90	R:R:Y39	10.6792	12.38	No	Yes	0	6	7
16	R:R:W292	R:R:Y39	25.0716	7.72	Yes	Yes	0	5	7
17	R:R:M291	R:R:M295	97.1518	4.33	No	No	0	5	7
18	R:R:M295	R:R:M81	95.7587	4.33	No	No	0	7	7
19	R:R:M81	R:R:S119	93.124	3.07	No	No	0	7	9
20	R:R:E78	R:R:S119	17.2687	5.75	Yes	No	6	9	9
21	R:R:E78	R:R:T298	11.2016	7.06	Yes	No	0	9	9
22	R:R:L74	R:R:S119	75.4452	3	No	No	6	9	9
23	R:R:L74	R:R:S122	83.6919	3	No	No	0	9	8
24	R:R:N73	R:R:S122	83.2369	8.94	No	No	0	9	8
25	R:R:I151	R:R:N73	87.8883	5.66	No	No	0	8	9
26	R:R:F70	R:R:I151	87.1973	5.02	Yes	No	0	7	8
27	R:R:D129	R:R:F70	76.9507	8.36	No	Yes	0	9	7
28	R:R:D129	R:R:F128	73.0352	4.78	No	No	0	9	5
29	R:R:F128	R:R:M132	72.1533	3.73	No	No	0	5	5
30	R:R:H136	R:R:M132	71.26	3.94	Yes	No	0	6	5
31	R:R:H136	R:R:I135	67.5749	5.3	Yes	Yes	0	6	7
32	R:R:I135	R:R:V219	61.9909	3.07	Yes	No	0	7	8
33	R:R:M250	R:R:V219	59.918	4.56	Yes	No	0	8	8
34	R:R:M250	R:R:Y216	49.4467	20.35	Yes	Yes	0	8	9
35	R:R:R130	R:R:Y216	43.5313	7.2	No	Yes	0	9	9
36	R:R:R130	R:R:Y305	41.0763	3.09	No	No	0	9	9
37	R:R:F312	R:R:Y305	38.6214	3.09	Yes	No	0	9	9
38	R:R:E78	R:R:N50	12.6004	9.2	Yes	No	0	9	9
39	R:R:F312	R:R:I56	15.9485	3.77	Yes	Yes	0	9	8
40	R:R:F70	R:R:T147	10.1286	3.89	Yes	No	0	7	7
41	R:R:N73	R:R:W155	14.7969	5.65	No	No	0	9	9
42	R:R:W98	R:R:Y92	17.2013	8.68	Yes	Yes	0	8	4
43	R:R:C105	R:R:W98	13.2352	3.92	Yes	Yes	1	9	8
44	R:R:W184	R:R:Y168	13.106	3.86	Yes	No	1	5	5
45	R:R:Y167	R:R:Y168	12.7409	5.96	No	No	0	4	5
46	R:R:F163	R:R:Y167	12.1173	5.16	No	No	0	4	4
47	R:R:F110	R:R:F163	11.0724	3.22	No	No	0	6	4
48	R:R:F110	R:R:L159	10.6005	3.65	No	No	0	6	4
49	R:R:F117	R:R:I113	19.2012	3.77	No	Yes	0	7	5
50	R:R:A114	R:R:L159	10.696	3.15	No	No	0	5	4
51	R:R:A118	R:R:W155	13.606	9.08	No	No	0	7	9
52	R:R:Q165	R:R:Y196	16.5833	11.27	No	No	0	6	6
53	R:R:F267	R:R:Y287	46.7277	7.22	Yes	Yes	0	4	5
54	R:R:F267	R:R:I290	13.5947	5.02	Yes	No	0	4	6
55	R:R:I290	R:R:P263	12.2296	3.39	No	No	0	6	9
56	R:R:F264	R:R:F268	10.3758	12.86	No	No	0	7	6
57	R:R:S296	R:R:W292	20.5887	2.47	No	Yes	0	5	5
58	R:R:S296	R:R:Y300	19.072	3.82	No	No	0	5	5
59	R:R:T256	R:R:Y300	16.0047	6.24	No	No	0	6	5
60	R:R:T256	R:R:V252	14.4542	1.59	No	No	0	6	5
61	R:R:K248	R:R:V252	12.8925	7.59	No	No	0	6	5
62	R:R:I251	R:R:K248	11.3196	7.27	No	No	0	5	6
63	R:R:F267	R:R:Y278	10.0444	10.32	Yes	No	9	4	2
64	R:R:A114	R:R:A158	10.9713	1.79	No	No	0	5	8
65	R:R:N89	R:R:Y287	31.5151	4.65	Yes	Yes	0	6	5
66	R:R:F267	R:R:F268	25.5828	3.22	Yes	No	0	4	6
67	R:R:A118	R:R:A158	11.5836	1.79	No	No	0	7	8
68	R:R:W184	R:R:Y196	15.8924	6.75	Yes	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:E172	8.14	0	No	No	0	3	0	1
L:L:R1	R:R:E183	4.65	0	No	No	0	3	0	1
L:L:K3	R:R:L279	4.23	0	No	No	0	2	0	1
L:L:Q5	R:R:Q24	7.68	0	No	No	0	3	0	1
L:L:F7	R:R:F25	9.65	2	Yes	Yes	0	6	0	1
L:L:F7	R:R:N96	8.46	2	Yes	Yes	0	4	0	1
L:L:F7	R:R:Q284	8.2	2	Yes	Yes	0	4	0	1
L:L:F7	R:R:Y287	9.28	2	Yes	Yes	0	5	0	1
L:L:F8	R:R:Y92	3.09	4	Yes	Yes	0	4	0	1
L:L:F8	R:R:V179	7.87	4	Yes	No	0	3	0	1
L:L:L10	R:R:Y92	4.69	0	No	Yes	0	4	0	1
L:L:M11	R:R:I113	4.37	1	Yes	Yes	0	5	0	1
L:L:M11	R:R:Q165	4.08	1	Yes	No	0	6	0	1
L:L:M11	R:R:F268	8.71	1	Yes	No	0	6	0	1
L:L:?12	R:R:N85	10.2	1	Yes	No	0	6	0	1
L:L:?12	R:R:N89	10.2	1	Yes	Yes	0	6	0	1
L:L:?12	R:R:H108	6.36	1	Yes	No	0	5	0	1
R:R:F25	R:R:Q24	8.2	2	Yes	No	6	3	1	1
R:R:F25	R:R:N96	10.87	2	Yes	Yes	6	4	1	1
R:R:F25	R:R:R177	5.34	2	Yes	Yes	6	2	1	2
R:R:F25	R:R:Q284	7.03	2	Yes	Yes	6	4	1	1
R:R:Q27	R:R:Q284	7.68	0	No	Yes	4	4	2	1
R:R:N85	R:R:N89	5.45	1	No	Yes	6	6	1	1
R:R:N85	R:R:P112	6.52	1	No	No	6	6	1	2
R:R:H108	R:R:V88	8.3	1	No	Yes	5	5	1	2
R:R:H108	R:R:N89	10.2	1	No	Yes	5	6	1	1
R:R:N89	R:R:Y287	4.65	1	Yes	Yes	6	5	1	1
R:R:N96	R:R:Y92	3.49	2	Yes	Yes	4	4	1	1
R:R:W98	R:R:Y92	8.68	1	Yes	Yes	8	4	2	1
R:R:N96	R:R:R177	8.44	2	Yes	Yes	4	2	1	2
R:R:F117	R:R:I113	3.77	0	No	Yes	7	5	2	1
R:R:A162	R:R:I113	3.25	0	No	Yes	7	5	2	1
R:R:I113	R:R:Q165	4.12	1	Yes	No	5	6	1	1
R:R:Q165	R:R:Y196	11.27	1	No	No	6	6	1	2
R:R:E172	R:R:M181	5.41	0	No	No	3	4	1	2
R:R:M174	R:R:P175	3.35	0	No	No	1	2	1	2
R:R:R177	R:R:V179	3.92	2	Yes	No	2	3	2	1
R:R:E183	R:R:E186	3.81	0	No	No	3	3	1	2
R:R:F264	R:R:F268	12.86	0	No	No	7	6	2	1
R:R:F267	R:R:F268	3.22	9	Yes	No	4	6	2	1
R:R:F267	R:R:Y287	7.22	9	Yes	Yes	4	5	2	1
R:R:M291	R:R:Y287	3.59	0	No	Yes	5	5	2	1
R:R:K281	R:R:Q284	2.71	0	No	Yes	2	4	2	1
L:L:F8	R:R:M174	2.49	4	Yes	No	0	1	0	1
R:R:D276	R:R:L279	1.36	0	No	No	1	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RMH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	277
Number of Links	299
Number of Hubs	33
Number of Links mediated by Hubs	118
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	38558
Length Of Smallest Path	3
Average Path Length	15.1819
Length of Longest Path	36
Minimum Path Strength	1.385
Average Path Strength	5.47632
Maximum Path Strength	13.775
Minimum Path Correlation	0.7
Average Path Correlation	0.921895
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	46.1165
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.9242
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • system process • circulatory system process • regulation of blood pressure • blood circulation • detection of stimulus • response to abiotic stimulus • detection of abiotic stimulus • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • acute inflammatory response • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • positive regulation of cellular process • trans-synaptic signaling • regulation of signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • cell-cell signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • regulation of synaptic transmission, GABAergic • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to endogenous stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • behavior • learning or memory • long-term memory • nervous system process • cognition • memory • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • positive regulation of lymphocyte activation • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • regulation of immune system process • regulation of multicellular organismal process • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • cell population proliferation • cell activation • positive regulation of lymphocyte proliferation • regulation of cell population proliferation • mononuclear cell proliferation • immune system process • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • positive regulation of multicellular organismal process • regulation of lymphocyte activation • learning • associative learning • ossification • positive regulation of ossification • regulation of ossification • tachykinin receptor signaling pathway • sensory perception • sensory perception of pain • heart process • negative regulation of heart rate • regulation of heart contraction • regulation of system process • negative regulation of biological process • negative regulation of blood circulation • negative regulation of heart contraction • regulation of blood circulation • heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • positive regulation of synaptic transmission, cholinergic • synaptic transmission, cholinergic • regulation of synaptic transmission, cholinergic • multi-multicellular organism process • reproductive process • multicellular organismal reproductive process • reproductive behavior • insemination • mating behavior • multi-organism reproductive process • copulation • regulation of localization • corticosterone secretion • positive regulation of steroid hormone secretion • localization • regulation of glucocorticoid secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • positive regulation of secretion by cell • organic hydroxy compound transport • hormone secretion • positive regulation of corticosterone secretion • secretion by cell • positive regulation of hormone secretion • regulation of secretion by cell • positive regulation of secretion • signal release • secretion • regulation of transport • lipid localization • export from cell • positive regulation of lipid localization • endocrine process • positive regulation of transport • regulation of lipid localization • macromolecule localization • hormone transport • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • positive regulation of supramolecular fiber organization • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • response to hormone • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of epithelial cell migration • tissue migration • ameboidal-type cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • epithelial cell migration • cell motility • regulation of epithelial cell migration • locomotion • epithelium migration • regulation of locomotion • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • synapse • cell junction • somatodendritic compartment • cell body • neuronal cell body • axon • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular space • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • tachykinin receptor activity • neuropeptide receptor activity • substance P receptor activity • regulation of systemic arterial blood pressure by renin-angiotensin • multicellular organismal process • regulation of systemic arterial blood pressure by hormone • regulation of blood volume by renin-angiotensin • regulation of systemic arterial blood pressure mediated by a chemical signal • system process • nervous system process • regulation of blood pressure • feeding behavior • biological regulation • brain renin-angiotensin system • behavior • regulation of systemic arterial blood pressure • circulatory system process • endocrine process • drinking behavior • angiotensin-mediated drinking behavior • regulation of biological quality • nervous system process involved in regulation of systemic arterial blood pressure • blood circulation • positive regulation of cell communication • regulation of localization • regulation of cellular process • regulation of hormone secretion • signaling • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • cell communication • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • positive regulation of cellular process • regulation of signaling • regulation of biological process • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • cellular process • positive regulation of signaling • regulation of tube diameter • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • response to ketone • response to lipid • response to stimulus • response to hormone • response to steroid hormone • response to chemical • response to endogenous stimulus • response to progesterone • response to oxygen-containing compound • cell population proliferation • regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • smooth muscle cell proliferation • regulation of cell motility • regulation of smooth muscle cell migration • smooth muscle cell migration • muscle cell migration • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • excretion • micturition • renal system process • smooth muscle contraction involved in micturition • urinary bladder smooth muscle contraction • muscle contraction • muscle system process • smooth muscle contraction • urinary tract smooth muscle contraction • response to stress • multicellular organismal response to stress • response to pain • behavioral response to pain • multi-multicellular organism process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • response to electrical stimulus • response to abiotic stimulus • cellular response to stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • positive regulation of lymphocyte activation • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • regulation of immune system process • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • cell activation • positive regulation of lymphocyte proliferation • mononuclear cell proliferation • immune system process • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • regulation of lymphocyte activation • regulation of vascular permeability • positive regulation of vascular permeability • tachykinin receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • detection of stimulus • detection of abiotic stimulus • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • response to oxidative stress • response to ozone • response to reactive oxygen species • positive regulation of blood pressure • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of muscle system process • uterine smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • eating behavior • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • response to alcohol • response to ethanol • learning or memory • long-term memory • cognition • memory • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • positive regulation of locomotion • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of cell migration • leukocyte migration • positive regulation of cell motility • response to auditory stimulus • response to mechanical stimulus • response to external stimulus • regulation of reproductive process • regulation of cilium-dependent cell motility • positive regulation of flagellated sperm motility • cilium or flagellum-dependent cell motility • regulation of flagellated sperm motility • cilium-dependent cell motility • positive regulation of cilium movement • positive regulation of reproductive process • sperm motility • positive regulation of cilium-dependent cell motility • regulation of microtubule-based process • regulation of microtubule-based movement • cilium movement involved in cell motility • regulation of cilium movement • flagellated sperm motility • microtubule-based movement • microtubule-based process • cilium movement • regulation of cilium movement involved in cell motility • aggressive behavior • learning • associative learning • ossification • positive regulation of ossification • regulation of ossification • defense response • inflammatory response • response to nicotine • operant conditioning • positive regulation of synaptic transmission, cholinergic • synaptic transmission, cholinergic • regulation of synaptic transmission, cholinergic • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • positive regulation of supramolecular fiber organization • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • response to estradiol • positive regulation of epithelial cell migration • tissue migration • ameboidal-type cell migration • epithelial cell migration • regulation of epithelial cell migration • epithelium migration • cell periphery • postsynapse • postsynaptic membrane • membrane • plasma membrane • plasma membrane region • synaptic membrane • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • dendrite • dendritic tree • sperm midpiece • sperm head • cell surface • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to prostaglandin • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • developmental growth • growth • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • establishment of protein localization • nitrogen compound transport • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • amide transport • intracellular protein localization • regulation of peptide hormone secretion • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25103
Sequence	>7RMH_nogp_Chain_R N Q F V Q P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H K R M R T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N E W Y Y G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H P L Q P R L S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S T T E T M P S R V V C M I E W P E H P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N P D L Y L K K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F R L G F K H A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6HLL	A	Peptide	Tachykinin	NK₁	Homo sapiens	CP99994	-	-	3.27	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLO	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.4	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLP	A	Peptide	Tachykinin	NK₁	Homo sapiens	Netupitant	-	-	2.2	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6J20	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.7	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	6J21	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	3.2	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	7RMG	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMG (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	8U26	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	Gs/β1/γ2	2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	8U26 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	6E59	A	Peptide	Tachykinin	NK₁	Homo sapiens	L-760735	-	-	3.4	2018-12-12	doi.org/10.1073/pnas.1812717115
	7P00	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P00 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	chim(NtGi1-Gs)/β1/γ2	2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872

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