psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R1	R:R:E172	15.12	No	No	0	0	3
2	L:L:P2	L:L:Q6	6.32	No	No	0	0	0
3	L:L:P4	L:L:Q5	7.9	No	No	0	0	0
4	L:L:Q5	R:R:Q24	7.68	No	No	0	0	3
5	L:L:F8	L:L:Q6	18.74	No	No	0	0	0
6	L:L:F7	R:R:N96	8.46	No	Yes	0	0	4
7	L:L:F7	R:R:Q284	4.68	No	Yes	0	0	4
8	L:L:F7	R:R:Y287	11.35	No	Yes	0	0	5
9	L:L:F8	R:R:V179	6.55	No	No	0	0	3
10	L:L:F8	R:R:M181	4.98	No	No	0	0	4
11	L:L:G9	R:R:Y287	5.79	No	Yes	0	0	5
12	L:L:?12	L:L:L10	3.43	Yes	No	0	0	0
13	L:L:L10	R:R:Y92	4.69	No	Yes	0	0	4
14	L:L:L10	R:R:N109	10.98	No	No	0	0	5
15	L:L:?12	L:L:M11	3.5	Yes	Yes	1	0	0
16	L:L:M11	R:R:I113	5.83	Yes	Yes	1	0	5
17	L:L:M11	R:R:Q165	8.16	Yes	Yes	1	0	6
18	L:L:M11	R:R:F264	3.73	Yes	Yes	1	0	7
19	L:L:M11	R:R:F268	12.44	Yes	No	1	0	6
20	L:L:?12	R:R:N85	10.2	Yes	Yes	1	0	6
21	L:L:?12	R:R:N89	10.2	Yes	Yes	1	0	6
22	L:L:?12	R:R:H108	6.36	Yes	Yes	1	0	5
23	R:R:N23	R:R:R177	14.46	No	Yes	0	8	2
24	R:R:F25	R:R:Q24	14.05	No	No	0	6	3
25	R:R:F25	R:R:N96	9.67	No	Yes	0	6	4
26	R:R:F25	R:R:Q284	11.71	No	Yes	0	6	4
27	R:R:H95	R:R:V26	5.54	No	No	0	5	1
28	R:R:Q27	R:R:Q31	5.12	No	Yes	0	4	2
29	R:R:I32	R:R:Q27	4.12	No	No	0	3	4
30	R:R:Q27	R:R:Q284	12.8	No	Yes	0	4	4
31	R:R:P28	R:R:W30	9.46	No	No	3	2	1
32	R:R:P28	R:R:Q31	7.9	No	Yes	3	2	2
33	R:R:Q31	R:R:W30	14.24	Yes	No	3	2	1
34	R:R:Q285	R:R:Q31	5.12	No	Yes	0	1	2
35	R:R:I32	R:R:V94	6.14	No	No	0	3	5
36	R:R:W35	R:R:Y39	3.86	Yes	Yes	1	4	7
37	R:R:Q285	R:R:W35	4.38	No	Yes	0	1	4
38	R:R:L288	R:R:W35	19.36	No	Yes	1	3	4
39	R:R:F90	R:R:Y39	13.41	No	Yes	0	6	7
40	R:R:L288	R:R:Y39	5.86	No	Yes	1	3	7
41	R:R:M291	R:R:Y39	4.79	Yes	Yes	1	5	7
42	R:R:W292	R:R:Y39	7.72	Yes	Yes	0	5	7
43	R:R:I42	R:R:W292	12.92	No	Yes	0	7	5
44	R:R:I42	R:R:M299	5.83	No	No	0	7	7
45	R:R:T86	R:R:V43	4.76	No	No	0	7	6
46	R:R:M299	R:R:T45	9.03	No	No	0	7	4
47	R:R:A82	R:R:S46	3.42	No	No	4	6	8
48	R:R:S46	R:R:T298	7.99	No	No	4	8	9
49	R:R:M299	R:R:S46	4.6	No	No	0	7	8
50	R:R:G49	R:R:P302	4.06	No	No	0	8	9
51	R:R:E78	R:R:N50	6.57	Yes	No	0	9	9
52	R:R:F316	R:R:V52	9.18	No	No	0	6	6
53	R:R:A319	R:R:V52	3.39	No	No	0	4	6
54	R:R:P302	R:R:V53	3.53	No	No	0	9	8
55	R:R:F312	R:R:V53	3.93	Yes	No	0	9	8
56	R:R:F76	R:R:M54	4.98	No	No	0	6	7
57	R:R:A59	R:R:W55	6.48	No	Yes	0	4	4
58	R:R:H60	R:R:W55	5.29	No	Yes	0	5	4
59	R:R:H318	R:R:W55	5.29	No	Yes	0	3	4
60	R:R:A319	R:R:W55	3.89	No	Yes	0	4	4
61	R:R:H60	R:R:I56	6.63	No	No	0	5	8
62	R:R:F312	R:R:I56	7.54	Yes	No	0	9	8
63	R:R:G315	R:R:I56	3.53	No	No	0	6	8
64	R:R:I57	R:R:N68	7.08	No	No	0	7	8
65	R:R:I57	R:R:V72	6.14	No	No	0	7	6
66	R:R:F312	R:R:I57	3.77	Yes	No	0	9	7
67	R:R:L58	R:R:R64	3.64	No	No	0	2	6
68	R:R:K61	R:R:R64	7.43	No	No	0	6	6
69	R:R:M63	R:R:R62	9.93	No	No	0	7	5
70	R:R:M63	R:R:R311	6.2	No	No	0	7	6
71	R:R:R64	R:R:Y69	11.32	No	No	0	6	5
72	R:R:V66	R:R:Y69	5.05	No	No	0	6	5
73	R:R:R141	R:R:V66	5.23	No	No	0	5	6
74	R:R:R141	R:R:T67	5.17	No	No	0	5	8
75	R:R:L71	R:R:N68	5.49	No	No	0	8	8
76	R:R:T147	R:R:Y69	4.99	No	No	0	7	5
77	R:R:A125	R:R:F70	5.55	No	Yes	0	7	7
78	R:R:D129	R:R:F70	9.55	No	Yes	0	9	7
79	R:R:F70	R:R:T147	6.49	Yes	No	0	7	7
80	R:R:F70	R:R:V150	6.55	Yes	No	0	7	5
81	R:R:F70	R:R:I151	5.02	Yes	No	0	7	8
82	R:R:L71	R:R:Y305	8.21	No	No	0	8	9
83	R:R:N73	R:R:S122	8.94	No	No	0	9	8
84	R:R:I151	R:R:N73	8.5	No	No	0	8	9
85	R:R:N73	R:R:W155	9.04	No	Yes	0	9	9
86	R:R:E78	R:R:L74	7.95	Yes	No	0	9	9
87	R:R:F76	R:R:S80	6.61	No	No	0	6	6
88	R:R:E78	R:R:T298	7.06	Yes	No	0	9	9
89	R:R:E78	R:R:N301	6.57	Yes	No	0	9	9
90	R:R:M295	R:R:M81	5.78	No	No	0	7	7
91	R:R:A82	R:R:T298	5.03	No	No	4	6	9
92	R:R:N85	R:R:N89	6.81	Yes	Yes	1	6	6
93	R:R:H108	R:R:N85	3.83	Yes	Yes	1	5	6
94	R:R:N85	R:R:P112	6.52	Yes	Yes	1	6	6
95	R:R:M295	R:R:T86	9.03	No	No	0	7	7
96	R:R:V88	R:R:Y104	5.05	No	No	0	5	5
97	R:R:H108	R:R:V88	15.22	Yes	No	0	5	5
98	R:R:H108	R:R:N89	8.93	Yes	Yes	1	5	6
99	R:R:N89	R:R:Y287	4.65	Yes	Yes	1	6	5
100	R:R:M291	R:R:N89	4.21	Yes	Yes	1	5	6
101	R:R:F90	R:R:V94	7.87	No	No	0	6	5
102	R:R:T91	R:R:Y100	6.24	No	No	0	4	7
103	R:R:N96	R:R:Y92	4.65	Yes	Yes	0	4	4
104	R:R:W98	R:R:Y92	12.54	Yes	Yes	2	8	4
105	R:R:C180	R:R:Y92	4.03	No	Yes	2	9	4
106	R:R:H95	R:R:V94	8.3	No	No	0	5	5
107	R:R:E97	R:R:H95	4.92	No	No	0	4	5
108	R:R:N96	R:R:R177	7.23	Yes	Yes	0	4	2
109	R:R:E97	R:R:Y99	8.98	No	No	0	4	2
110	R:R:W98	R:R:Y100	17.36	Yes	No	0	8	7
111	R:R:C105	R:R:W98	3.92	No	Yes	2	9	8
112	R:R:C180	R:R:W98	11.75	No	Yes	2	9	8
113	R:R:Y100	R:R:Y104	10.92	No	No	0	7	5
114	R:R:L102	R:R:T171	4.42	No	No	0	3	5
115	R:R:F107	R:R:Y104	4.13	No	No	0	4	5
116	R:R:C105	R:R:S169	5.16	No	Yes	0	9	5
117	R:R:C105	R:R:C180	7.28	No	No	2	9	9
118	R:R:K106	R:R:S169	6.12	No	Yes	0	6	5
119	R:R:F107	R:R:F111	10.72	No	No	0	4	4
120	R:R:H108	R:R:P112	6.1	Yes	Yes	1	5	6
121	R:R:N109	R:R:S169	8.94	No	Yes	0	5	5
122	R:R:I182	R:R:N109	5.66	No	No	0	4	5
123	R:R:F110	R:R:L159	4.87	No	No	0	6	4
124	R:R:F110	R:R:F163	9.65	No	No	0	6	4
125	R:R:F111	R:R:P112	5.78	No	Yes	0	4	6
126	R:R:F117	R:R:I113	5.02	Yes	Yes	1	7	5
127	R:R:I113	R:R:Q165	5.49	Yes	Yes	1	5	6
128	R:R:F117	R:R:V116	3.93	Yes	No	0	7	7
129	R:R:F117	R:R:L161	10.96	Yes	No	1	7	5
130	R:R:F117	R:R:V200	3.93	Yes	No	1	7	5
131	R:R:F117	R:R:I204	15.07	Yes	No	0	7	6
132	R:R:A118	R:R:W155	9.08	No	Yes	0	7	9
133	R:R:I120	R:R:P208	3.39	Yes	No	0	7	9
134	R:R:F257	R:R:I120	3.77	Yes	Yes	1	9	7
135	R:R:I120	R:R:W261	3.52	Yes	Yes	1	7	8
136	R:R:I154	R:R:Y121	4.84	No	No	0	7	5
137	R:R:I204	R:R:Y121	3.63	No	No	0	6	5
138	R:R:F257	R:R:M123	4.98	Yes	No	0	9	8
139	R:R:P208	R:R:T124	3.5	No	No	0	9	7
140	R:R:I212	R:R:T124	9.12	No	No	0	8	7
141	R:R:R130	R:R:V126	6.54	Yes	No	0	9	9
142	R:R:A127	R:R:I212	4.87	No	No	5	9	8
143	R:R:A127	R:R:Y216	5.34	No	Yes	5	9	9
144	R:R:F128	R:R:M132	8.71	No	No	0	5	5
145	R:R:D129	R:R:R141	5.96	No	No	0	9	5
146	R:R:R130	R:R:Y216	9.26	Yes	Yes	0	9	9
147	R:R:M249	R:R:R130	3.72	Yes	Yes	0	8	9
148	R:R:I135	R:R:Y131	12.09	Yes	No	0	7	8
149	R:R:A215	R:R:Y131	4	No	No	0	7	8
150	R:R:V218	R:R:Y131	5.05	No	No	0	4	8
151	R:R:I134	R:R:V219	7.68	No	No	0	8	8
152	R:R:I134	R:R:L223	5.71	No	No	0	8	8
153	R:R:H136	R:R:I135	7.95	Yes	Yes	0	6	7
154	R:R:I135	R:R:T222	4.56	Yes	No	0	7	5
155	R:R:P140	R:R:Q139	4.74	No	No	0	6	4
156	R:R:L161	R:R:V200	5.96	No	No	1	5	5
157	R:R:F163	R:R:Y167	5.16	No	No	0	4	4
158	R:R:P164	R:R:Y196	5.56	No	No	0	8	6
159	R:R:I182	R:R:Q165	5.49	No	Yes	0	4	6
160	R:R:Q165	R:R:Y196	13.53	Yes	No	0	6	6
161	R:R:Y167	R:R:Y168	6.95	No	No	0	4	5
162	R:R:W184	R:R:Y168	4.82	Yes	No	0	5	5
163	R:R:P185	R:R:Y168	12.52	No	No	0	4	5
164	R:R:M174	R:R:R177	3.72	No	Yes	0	1	2
165	R:R:R177	R:R:V179	3.92	Yes	No	0	2	3
166	R:R:I182	R:R:W184	8.22	No	Yes	0	4	5
167	R:R:E193	R:R:W184	18.54	No	Yes	0	4	5
168	R:R:W184	R:R:Y196	7.72	Yes	No	0	5	6
169	R:R:H187	R:R:P188	13.73	No	No	0	2	1
170	R:R:H187	R:R:I191	9.28	No	No	0	2	1
171	R:R:E193	R:R:K190	22.95	No	No	0	4	2
172	R:R:E193	R:R:Y272	13.47	No	Yes	0	4	5
173	R:R:K194	R:R:Y272	8.36	No	Yes	0	3	5
174	R:R:H197	R:R:Y272	10.89	No	Yes	0	5	5
175	R:R:H265	R:R:T201	8.21	Yes	No	0	7	6
176	R:R:L269	R:R:T201	10.32	No	No	0	5	6
177	R:R:F206	R:R:V202	3.93	No	No	0	4	4
178	R:R:H265	R:R:I204	3.98	Yes	No	0	7	6
179	R:R:F206	R:R:Y205	5.16	No	Yes	0	4	8
180	R:R:L209	R:R:Y205	3.52	No	Yes	0	6	8
181	R:R:L262	R:R:Y205	7.03	No	Yes	0	5	8
182	R:R:H265	R:R:Y205	8.71	Yes	Yes	0	7	8
183	R:R:F257	R:R:L209	6.09	Yes	No	0	9	6
184	R:R:I212	R:R:Y216	3.63	No	Yes	5	8	9
185	R:R:V218	R:R:Y214	5.05	No	No	0	4	4
186	R:R:M250	R:R:Y216	22.75	Yes	Yes	0	8	9
187	R:R:V254	R:R:Y216	3.79	No	Yes	0	8	9
188	R:R:M250	R:R:V219	4.56	Yes	No	0	8	8
189	R:R:G220	R:R:V247	5.52	No	Yes	0	5	6
190	R:R:R244	R:R:W224	27.99	No	No	0	5	4
191	R:R:V247	R:R:W224	7.36	Yes	No	0	6	4
192	R:R:K243	R:R:Q239	8.14	No	No	0	7	4
193	R:R:R244	R:R:V240	3.92	No	No	0	5	2
194	R:R:M249	R:R:M250	4.33	Yes	Yes	0	8	8
195	R:R:I304	R:R:M249	4.37	No	Yes	0	8	8
196	R:R:L308	R:R:M249	7.07	No	Yes	0	7	8
197	R:R:T256	R:R:Y300	7.49	No	No	0	6	5
198	R:R:F257	R:R:W261	8.02	Yes	Yes	1	9	8
199	R:R:C260	R:R:S297	3.44	No	No	0	8	9
200	R:R:C260	R:R:Y300	4.03	No	No	0	8	5
201	R:R:F264	R:R:W261	8.02	Yes	Yes	1	7	8
202	R:R:S297	R:R:W261	4.94	No	Yes	0	9	8
203	R:R:I266	R:R:L262	7.14	No	No	0	6	5
204	R:R:I290	R:R:P263	5.08	No	No	0	6	9
205	R:R:F264	R:R:H265	6.79	Yes	Yes	0	7	7
206	R:R:F264	R:R:F268	13.93	Yes	No	1	7	6
207	R:R:A294	R:R:F264	5.55	No	Yes	0	7	7
208	R:R:F267	R:R:F268	6.43	Yes	No	1	4	6
209	R:R:F267	R:R:Y278	4.13	Yes	No	1	4	2
210	R:R:F267	R:R:I283	5.02	Yes	No	1	4	4
211	R:R:F267	R:R:Y287	5.16	Yes	Yes	1	4	5
212	R:R:F267	R:R:I290	5.02	Yes	No	0	4	6
213	R:R:L270	R:R:L277	4.15	No	No	0	4	5
214	R:R:P271	R:R:Y272	4.17	No	Yes	0	4	5
215	R:R:P271	R:R:Y278	11.13	No	No	0	4	2
216	R:R:L277	R:R:N274	4.12	No	No	0	5	4
217	R:R:I283	R:R:Y278	7.25	No	No	1	4	2
218	R:R:K281	R:R:Q284	5.42	No	Yes	0	2	4
219	R:R:F282	R:R:V286	6.55	No	No	0	3	5
220	R:R:Q284	R:R:Q285	3.84	Yes	No	0	4	1
221	R:R:M291	R:R:Y287	4.79	Yes	Yes	1	5	5
222	R:R:M291	R:R:M295	4.33	Yes	No	0	5	7
223	R:R:S296	R:R:W292	6.18	No	Yes	0	5	5
224	R:R:F312	R:R:Y305	7.22	Yes	No	0	9	9
225	R:R:C306	R:R:F316	4.19	No	No	0	7	6
226	R:R:D310	R:R:N309	4.04	No	No	0	4	8
227	R:R:N309	R:R:R311	3.62	No	No	0	8	6
228	R:R:F312	R:R:N309	3.62	Yes	No	0	9	8
229	R:R:D310	R:R:R313	3.57	No	No	0	4	8
230	R:R:F316	R:R:F320	5.36	No	No	0	6	6
231	L:L:K3	L:L:P4	3.35	No	No	0	0	0
232	R:R:L293	R:R:P263	3.28	No	No	0	7	9
233	R:R:H187	R:R:Y192	3.27	No	No	0	2	4
234	R:R:N189	R:R:P188	3.26	No	No	0	3	1
235	R:R:N274	R:R:P275	3.26	No	No	0	4	3
236	R:R:A162	R:R:I113	3.25	No	Yes	0	7	5
237	R:R:A75	R:R:M54	3.22	No	No	0	9	7
238	R:R:D276	R:R:P275	3.22	No	No	0	1	3
239	R:R:T124	R:R:V211	3.17	No	No	0	7	6
240	R:R:A93	R:R:L288	3.15	No	No	0	5	3
241	R:R:A114	R:R:L159	3.15	No	No	0	5	4
242	R:R:A146	R:R:L142	3.15	No	No	0	4	6
243	R:R:A258	R:R:L209	3.15	No	No	0	5	6
244	R:R:T65	R:R:T67	3.14	No	No	0	7	8
245	R:R:A79	R:R:N50	3.13	No	No	0	7	9
246	R:R:I120	R:R:S119	3.1	Yes	No	0	7	9
247	R:R:R130	R:R:Y305	3.09	Yes	No	0	9	9
248	R:R:I135	R:R:V219	3.07	Yes	No	0	7	8
249	R:R:I154	R:R:V150	3.07	No	No	0	7	5
250	R:R:I283	R:R:V286	3.07	No	No	0	4	5
251	R:R:M250	R:R:V246	3.04	Yes	No	0	8	7
252	R:R:F76	R:R:W155	3.01	No	Yes	0	6	9
253	L:L:P2	L:L:R1	2.88	No	No	0	0	0
254	R:R:I273	R:R:L270	2.85	No	No	0	5	4
255	R:R:K243	R:R:L223	2.82	No	No	0	7	8
256	R:R:K245	R:R:L308	2.82	No	No	0	8	7
257	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
258	R:R:A36	R:R:F90	2.77	No	No	0	6	6
259	R:R:E183	R:R:M181	2.71	No	No	0	3	4
260	R:R:H136	R:R:M132	2.63	Yes	No	0	6	5
261	R:R:A38	R:R:W292	2.59	No	Yes	0	4	5
262	R:R:A77	R:R:W155	2.59	No	Yes	0	8	9
263	R:R:V253	R:R:Y216	2.52	No	Yes	0	7	9
264	R:R:H136	R:R:Q139	2.47	Yes	No	0	6	4
265	R:R:V178	R:R:W98	2.45	No	Yes	0	4	8
266	R:R:L34	R:R:W30	2.28	No	No	0	4	1
267	R:R:G166	R:R:S169	1.86	No	Yes	0	5	5
268	R:R:G213	R:R:V254	1.84	No	No	0	4	8
269	R:R:G213	R:R:T217	1.82	No	No	0	4	3
270	R:R:A114	R:R:A158	1.79	No	No	0	5	8
271	R:R:A118	R:R:A158	1.79	No	No	0	7	8
272	R:R:A115	R:R:S80	1.71	No	No	0	8	6
273	R:R:A146	R:R:S143	1.71	No	No	0	4	7
274	R:R:C152	R:R:V156	1.71	No	No	0	3	3
275	R:R:C199	R:R:V195	1.71	No	No	0	4	4
276	R:R:G315	R:R:L314	1.71	No	No	0	6	4
277	R:R:A82	R:R:V47	1.7	No	No	0	6	6
278	R:R:A83	R:R:V47	1.7	No	No	0	4	6
279	R:R:A144	R:R:V66	1.7	No	No	0	2	6
280	R:R:M174	R:R:P175	1.68	No	No	0	1	2
281	R:R:L207	R:R:P208	1.64	No	No	0	5	9
282	R:R:C255	R:R:I251	1.64	No	No	0	4	5
283	R:R:L270	R:R:P271	1.64	No	No	0	4	4
284	R:R:C307	R:R:I303	1.64	No	No	0	6	7
285	R:R:V43	R:R:V44	1.6	No	No	0	6	4
286	R:R:V44	R:R:V48	1.6	No	No	0	4	4
287	R:R:V47	R:R:V48	1.6	No	No	0	6	4
288	R:R:V48	R:R:V52	1.6	No	No	0	4	6
289	R:R:S143	R:R:T145	1.6	No	No	0	7	4
290	R:R:V149	R:R:V153	1.6	No	No	0	3	3
291	R:R:T40	R:R:V44	1.59	No	No	0	4	4
292	R:R:T45	R:R:V41	1.59	No	No	0	4	5
293	R:R:T171	R:R:V178	1.59	No	No	0	5	4
294	R:R:T256	R:R:V252	1.59	No	No	0	6	5
295	R:R:E21	R:R:P22	1.57	No	No	0	3	7
296	R:R:I191	R:R:V195	1.54	No	No	0	1	4
297	R:R:I251	R:R:V247	1.54	No	Yes	0	5	6
298	R:R:H136	R:R:P137	1.53	Yes	No	0	6	8
299	R:R:I221	R:R:T217	1.52	No	No	0	3	3
300	R:R:M181	R:R:T170	1.51	No	No	0	4	4
301	R:R:N23	R:R:S176	1.49	No	No	0	8	5
302	R:R:L157	R:R:V153	1.49	No	No	0	4	3
303	R:R:L157	R:R:V156	1.49	No	No	0	4	3
304	R:R:L223	R:R:V247	1.49	No	Yes	0	8	6
305	R:R:L142	R:R:T147	1.47	No	No	0	6	7
306	R:R:F84	R:R:P112	1.44	No	Yes	0	5	6
307	R:R:I198	R:R:L269	1.43	No	No	0	5	5
308	R:R:L203	R:R:L207	1.38	No	No	0	4	5
309	R:R:A289	R:R:W35	1.3	No	Yes	0	5	4
310	R:R:F282	R:R:K280	1.24	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M11	6.732	5	1	0
2	L:L:?12	6.738	5	1	0
3	R:R:Q31	8.095	4	3	2
4	R:R:W35	7.225	4	1	4
5	R:R:Y39	7.128	5	1	7
6	R:R:W55	5.2375	4	0	4
7	R:R:F70	6.632	5	0	7
8	R:R:E78	7.0375	4	0	9
9	R:R:N85	6.84	4	1	6
10	R:R:N89	6.96	5	1	6
11	R:R:Y92	6.4775	4	2	4
12	R:R:N96	7.5025	4	0	4
13	R:R:W98	8.47167	6	2	8
14	R:R:H108	8.088	5	1	5
15	R:R:P112	4.96	4	1	6
16	R:R:I113	4.8975	4	1	5
17	R:R:F117	7.782	5	1	7
18	R:R:I120	3.445	4	1	7
19	R:R:R130	5.6525	4	0	9
20	R:R:I135	6.9175	4	0	7
21	R:R:H136	3.645	4	0	6
22	R:R:W155	5.93	4	0	9
23	R:R:Q165	8.1675	4	1	6
24	R:R:S169	5.52	4	0	5
25	R:R:R177	7.3325	4	0	2
26	R:R:W184	9.825	4	0	5
27	R:R:Y205	6.105	4	0	8
28	R:R:Y216	7.88167	6	5	9
29	R:R:V247	3.9775	4	0	6
30	R:R:M249	4.8725	4	0	8
31	R:R:M250	8.67	4	0	8
32	R:R:F257	5.715	4	1	9
33	R:R:W261	6.125	4	1	8
34	R:R:F264	7.604	5	1	7
35	R:R:H265	6.9225	4	0	7
36	R:R:F267	5.152	5	1	4
37	R:R:Y272	9.2225	4	0	5
38	R:R:Q284	7.69	5	0	4
39	R:R:Y287	6.348	5	1	5
40	R:R:M291	4.53	4	1	5
41	R:R:W292	7.3525	4	0	5
42	R:R:F312	5.216	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q5	R:R:Q24	10.9105	7.68	No	No	0	0	3
2	R:R:F25	R:R:Q24	14.5272	14.05	No	No	0	6	3
3	R:R:F25	R:R:N96	16.5463	9.67	No	Yes	0	6	4
4	R:R:N96	R:R:R177	37.1471	7.23	Yes	Yes	0	4	2
5	R:R:R177	R:R:V179	24.1245	3.92	Yes	No	0	2	3
6	L:L:F8	R:R:V179	21.4872	6.55	No	No	0	0	3
7	L:L:F8	L:L:Q6	10.8284	18.74	No	No	0	0	0
8	L:L:F7	R:R:N96	30.3239	8.46	No	Yes	0	0	4
9	L:L:F7	R:R:Q284	22.7347	4.68	No	Yes	0	0	4
10	R:R:F25	R:R:Q284	11.1567	11.71	No	Yes	0	6	4
11	L:L:F7	R:R:Y287	44.211	11.35	No	Yes	0	0	5
12	L:L:?12	L:L:L10	40.6489	3.43	Yes	No	0	0	0
13	L:L:L10	R:R:Y92	37.831	4.69	No	Yes	0	0	4
14	R:R:N96	R:R:Y92	33.9079	4.65	Yes	Yes	0	4	4
15	L:L:L10	R:R:N109	15.6216	10.98	No	No	0	0	5
16	L:L:?12	L:L:M11	85.8722	3.5	Yes	Yes	1	0	0
17	L:L:M11	R:R:I113	24.6608	5.83	Yes	Yes	1	0	5
18	L:L:M11	R:R:Q165	26.3515	8.16	Yes	Yes	1	0	6
19	R:R:I182	R:R:N109	15.8459	5.66	No	No	0	4	5
20	R:R:I182	R:R:Q165	16.6284	5.49	No	Yes	0	4	6
21	R:R:F267	R:R:Y287	60.6314	5.16	Yes	Yes	1	4	5
22	R:R:F267	R:R:F268	61.9501	6.43	Yes	No	1	4	6
23	R:R:F264	R:R:F268	59.2033	13.93	Yes	No	1	7	6
24	L:L:M11	R:R:F264	73.5883	3.73	Yes	Yes	1	0	7
25	L:L:?12	R:R:H108	11.6218	6.36	Yes	Yes	1	0	5
26	R:R:Q27	R:R:Q284	11.2607	12.8	No	Yes	0	4	4
27	R:R:H95	R:R:V94	10.3031	8.3	No	No	0	5	5
28	R:R:M291	R:R:Y287	35.4728	4.79	Yes	Yes	1	5	5
29	R:R:M291	R:R:Y39	52.8562	4.79	Yes	Yes	1	5	7
30	R:R:F90	R:R:Y39	16.3548	13.41	No	Yes	0	6	7
31	R:R:W292	R:R:Y39	28.179	7.72	Yes	Yes	0	5	7
32	R:R:I42	R:R:W292	22.1712	12.92	No	Yes	0	7	5
33	R:R:I42	R:R:M299	20.3108	5.83	No	No	0	7	7
34	R:R:M291	R:R:M295	35.5603	4.33	Yes	No	0	5	7
35	R:R:M295	R:R:T86	31.4894	9.03	No	No	0	7	7
36	R:R:T86	R:R:V43	29.9081	4.76	No	No	0	7	6
37	R:R:M299	R:R:S46	16.7159	4.6	No	No	0	7	8
38	R:R:S46	R:R:T298	10.6314	7.99	No	No	4	8	9
39	R:R:F264	R:R:W261	100	8.02	Yes	Yes	1	7	8
40	R:R:I120	R:R:W261	87.4152	3.52	Yes	Yes	1	7	8
41	R:R:I120	R:R:P208	88.6354	3.39	Yes	No	0	7	9
42	R:R:P208	R:R:T124	85.139	3.5	No	No	0	9	7
43	R:R:I212	R:R:T124	82.9394	9.12	No	No	0	8	7
44	R:R:I212	R:R:Y216	80.4717	3.63	No	Yes	5	8	9
45	R:R:R130	R:R:Y216	38.028	9.26	Yes	Yes	0	9	9
46	R:R:R130	R:R:Y305	37.3769	3.09	Yes	No	0	9	9
47	R:R:F312	R:R:Y305	33.2896	7.22	Yes	No	0	9	9
48	R:R:V43	R:R:V44	28.7207	1.6	No	No	0	6	4
49	R:R:V44	R:R:V48	26.3789	1.6	No	No	0	4	4
50	R:R:V48	R:R:V52	28.9177	1.6	No	No	0	4	6
51	R:R:A319	R:R:V52	23.9002	3.39	No	No	0	4	6
52	R:R:A319	R:R:W55	22.8004	3.89	No	Yes	0	4	4
53	R:R:H60	R:R:W55	20.2615	5.29	No	Yes	0	5	4
54	R:R:H60	R:R:I56	20.2451	6.63	No	No	0	5	8
55	R:R:F312	R:R:I56	21.427	7.54	Yes	No	0	9	8
56	R:R:E78	R:R:T298	11.7586	7.06	Yes	No	0	9	9
57	R:R:F264	R:R:H265	69.3095	6.79	Yes	Yes	0	7	7
58	R:R:H265	R:R:I204	56.1939	3.98	Yes	No	0	7	6
59	R:R:I204	R:R:Y121	73.4734	3.63	No	No	0	6	5
60	R:R:I154	R:R:Y121	71.334	4.84	No	No	0	7	5
61	R:R:I154	R:R:V150	69.2	3.07	No	No	0	7	5
62	R:R:F70	R:R:V150	67.0552	6.55	Yes	No	0	7	5
63	R:R:F70	R:R:I151	25.4925	5.02	Yes	No	0	7	8
64	R:R:I151	R:R:N73	23.1944	8.5	No	No	0	8	9
65	R:R:N73	R:R:W155	18.7951	9.04	No	Yes	0	9	9
66	R:R:F76	R:R:W155	12.9295	3.01	No	Yes	0	6	9
67	R:R:F117	R:R:I113	26.7509	5.02	Yes	Yes	1	7	5
68	R:R:F117	R:R:I204	23.7306	15.07	Yes	No	0	7	6
69	R:R:I182	R:R:W184	22.1876	8.22	No	Yes	0	4	5
70	R:R:W184	R:R:Y168	26.3843	4.82	Yes	No	0	5	5
71	R:R:Y167	R:R:Y168	20.5242	6.95	No	No	0	4	5
72	R:R:F163	R:R:Y167	17.8923	5.16	No	No	0	4	4
73	R:R:F110	R:R:F163	15.2659	9.65	No	No	0	6	4
74	R:R:F110	R:R:L159	12.645	4.87	No	No	0	6	4
75	R:R:A114	R:R:L159	10.0295	3.15	No	No	0	5	4
76	R:R:F70	R:R:T147	26.4664	6.49	Yes	No	0	7	7
77	R:R:T147	R:R:Y69	14.5163	4.99	No	No	0	7	5
78	R:R:F312	R:R:N309	12.065	3.62	Yes	No	0	9	8
79	R:R:D129	R:R:F70	14.4178	9.55	No	Yes	0	9	7
80	R:R:D129	R:R:R141	12.2073	5.96	No	No	0	9	5
81	R:R:W98	R:R:Y92	16.4369	12.54	Yes	Yes	2	8	4
82	R:R:M250	R:R:Y216	50.1094	22.75	Yes	Yes	0	8	9
83	R:R:M250	R:R:V219	48.1725	4.56	Yes	No	0	8	8
84	R:R:I135	R:R:V219	24.9453	3.07	Yes	No	0	7	8
85	R:R:H136	R:R:I135	12.6669	7.95	Yes	Yes	0	6	7
86	R:R:M249	R:R:R130	13.1265	3.72	Yes	Yes	0	8	9
87	R:R:M249	R:R:M250	12.7927	4.33	Yes	Yes	0	8	8
88	R:R:I134	R:R:V219	22.7949	7.68	No	No	0	8	8
89	R:R:I134	R:R:L223	20.8908	5.71	No	No	0	8	8
90	R:R:Q165	R:R:Y196	14.385	13.53	Yes	No	0	6	6
91	R:R:W184	R:R:Y196	11.9501	7.72	Yes	No	0	5	6
92	R:R:F267	R:R:Y278	15.2878	4.13	Yes	No	1	4	2
93	R:R:P271	R:R:Y278	14.5655	11.13	No	No	0	4	2
94	R:R:H265	R:R:Y205	11.2935	8.71	Yes	Yes	0	7	8
95	R:R:L223	R:R:V247	14.7406	1.49	No	Yes	0	8	6
96	R:R:S297	R:R:W261	10.1445	4.94	No	Yes	0	9	8
97	R:R:V47	R:R:V48	11.0473	1.6	No	No	0	6	4
98	R:R:F90	R:R:V94	11.671	7.87	No	No	0	6	5
99	L:L:?12	R:R:N89	45.858	10.2	Yes	Yes	1	0	6
100	R:R:M291	R:R:N89	47.7621	4.21	Yes	Yes	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R1	R:R:E172	15.12	0	No	No	0	3	0	1
L:L:Q5	R:R:Q24	7.68	0	No	No	0	3	0	1
L:L:F7	R:R:N96	8.46	0	No	Yes	0	4	0	1
L:L:F7	R:R:Q284	4.68	0	No	Yes	0	4	0	1
L:L:F7	R:R:Y287	11.35	0	No	Yes	0	5	0	1
L:L:F8	R:R:V179	6.55	0	No	No	0	3	0	1
L:L:F8	R:R:M181	4.98	0	No	No	0	4	0	1
L:L:G9	R:R:Y287	5.79	0	No	Yes	0	5	0	1
L:L:L10	R:R:Y92	4.69	0	No	Yes	0	4	0	1
L:L:L10	R:R:N109	10.98	0	No	No	0	5	0	1
L:L:M11	R:R:I113	5.83	1	Yes	Yes	0	5	0	1
L:L:M11	R:R:Q165	8.16	1	Yes	Yes	0	6	0	1
L:L:M11	R:R:F264	3.73	1	Yes	Yes	0	7	0	1
L:L:M11	R:R:F268	12.44	1	Yes	No	0	6	0	1
L:L:?12	R:R:N85	10.2	1	Yes	Yes	0	6	0	1
L:L:?12	R:R:N89	10.2	1	Yes	Yes	0	6	0	1
L:L:?12	R:R:H108	6.36	1	Yes	Yes	0	5	0	1
R:R:F25	R:R:Q24	14.05	0	No	No	6	3	2	1
R:R:F25	R:R:N96	9.67	0	No	Yes	6	4	2	1
R:R:F25	R:R:Q284	11.71	0	No	Yes	6	4	2	1
R:R:Q27	R:R:Q284	12.8	0	No	Yes	4	4	2	1
R:R:N85	R:R:N89	6.81	1	Yes	Yes	6	6	1	1
R:R:H108	R:R:N85	3.83	1	Yes	Yes	5	6	1	1
R:R:N85	R:R:P112	6.52	1	Yes	Yes	6	6	1	2
R:R:H108	R:R:V88	15.22	1	Yes	No	5	5	1	2
R:R:H108	R:R:N89	8.93	1	Yes	Yes	5	6	1	1
R:R:N89	R:R:Y287	4.65	1	Yes	Yes	6	5	1	1
R:R:M291	R:R:N89	4.21	1	Yes	Yes	5	6	2	1
R:R:N96	R:R:Y92	4.65	0	Yes	Yes	4	4	1	1
R:R:W98	R:R:Y92	12.54	2	Yes	Yes	8	4	2	1
R:R:C180	R:R:Y92	4.03	2	No	Yes	9	4	2	1
R:R:N96	R:R:R177	7.23	0	Yes	Yes	4	2	1	2
R:R:C180	R:R:W98	11.75	2	No	Yes	9	8	2	2
R:R:H108	R:R:P112	6.1	1	Yes	Yes	5	6	1	2
R:R:N109	R:R:S169	8.94	0	No	Yes	5	5	1	2
R:R:I182	R:R:N109	5.66	0	No	No	4	5	2	1
R:R:F117	R:R:I113	5.02	1	Yes	Yes	7	5	2	1
R:R:I113	R:R:Q165	5.49	1	Yes	Yes	5	6	1	1
R:R:I182	R:R:Q165	5.49	0	No	Yes	4	6	2	1
R:R:Q165	R:R:Y196	13.53	1	Yes	No	6	6	1	2
R:R:R177	R:R:V179	3.92	0	Yes	No	2	3	2	1
R:R:F264	R:R:W261	8.02	1	Yes	Yes	7	8	1	2
R:R:F264	R:R:H265	6.79	1	Yes	Yes	7	7	1	2
R:R:F264	R:R:F268	13.93	1	Yes	No	7	6	1	1
R:R:A294	R:R:F264	5.55	0	No	Yes	7	7	2	1
R:R:F267	R:R:F268	6.43	1	Yes	No	4	6	2	1
R:R:F267	R:R:Y287	5.16	1	Yes	Yes	4	5	2	1
R:R:K281	R:R:Q284	5.42	0	No	Yes	2	4	2	1
R:R:Q284	R:R:Q285	3.84	0	Yes	No	4	1	1	2
R:R:M291	R:R:Y287	4.79	1	Yes	Yes	5	5	2	1
R:R:A162	R:R:I113	3.25	0	No	Yes	7	5	2	1
R:R:E183	R:R:M181	2.71	0	No	No	3	4	2	1
R:R:M181	R:R:T170	1.51	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RMG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	279
Number of Links	310
Number of Hubs	42
Number of Links mediated by Hubs	149
Number of Communities	5
Number of Nodes involved in Communities	37
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	56853
Length Of Smallest Path	3
Average Path Length	13.5439
Length of Longest Path	27
Minimum Path Strength	1.49
Average Path Strength	6.28841
Maximum Path Strength	20.745
Minimum Path Correlation	0.7
Average Path Correlation	0.926453
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	48.9031
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.9653
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Substance-P
UniProt	P20366
Sequence	>7RMG_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P25103
Sequence	>7RMG_nogp_Chain_R E P N Q F V Q P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H K R M R T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N E W Y Y G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H P L Q P R L S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S T T E T M P S R V V C M I E W P E H P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N P D L Y L K K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F R L G F K H A F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6E59	A	Peptide	Tachykinin	NK₁	Homo sapiens	L-760735	-	-	3.4	2018-12-12	doi.org/10.1073/pnas.1812717115
	6HLL	A	Peptide	Tachykinin	NK₁	Homo sapiens	CP99994	-	-	3.27	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLO	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.4	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLP	A	Peptide	Tachykinin	NK₁	Homo sapiens	Netupitant	-	-	2.2	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6J20	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.7	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	6J21	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	3.2	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	7RMG	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMG (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7P00	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P00 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs)/β1/γ2	2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	8U26	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	8U26 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9

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