psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F25	R:R:N23	8.46	Yes	No	0	6	8
2	R:R:N23	R:R:V26	5.91	No	No	0	8	1
3	R:R:N23	R:R:R177	14.46	No	Yes	0	8	2
4	R:R:F25	R:R:Q24	14.05	Yes	No	1	6	3
5	R:R:K281	R:R:Q24	5.42	No	No	1	2	3
6	R:R:F25	R:R:K281	4.96	Yes	No	1	6	2
7	R:R:F25	R:R:Q284	11.71	Yes	Yes	1	6	4
8	L:L:F7	R:R:F25	15	Yes	Yes	1	0	6
9	R:R:H95	R:R:V26	11.07	No	No	0	5	1
10	R:R:Q27	R:R:Q31	7.68	Yes	Yes	1	4	2
11	R:R:I32	R:R:Q27	6.86	No	Yes	0	3	4
12	R:R:Q27	R:R:Q284	14.08	Yes	Yes	1	4	4
13	R:R:Q27	R:R:Q285	7.68	Yes	Yes	1	4	1
14	R:R:P28	R:R:W30	8.11	No	No	1	2	1
15	R:R:P28	R:R:Q31	15.79	No	Yes	1	2	2
16	R:R:Q31	R:R:W30	9.86	Yes	No	1	2	1
17	R:R:Q285	R:R:Q31	6.4	Yes	Yes	1	1	2
18	R:R:I32	R:R:V94	4.61	No	No	0	3	5
19	R:R:Q285	R:R:W35	6.57	Yes	No	0	1	4
20	R:R:L288	R:R:W35	17.08	No	No	0	3	4
21	R:R:F90	R:R:Y39	18.57	No	No	0	6	7
22	R:R:L288	R:R:Y39	5.86	No	No	0	3	7
23	R:R:W292	R:R:Y39	4.82	No	No	0	5	7
24	R:R:I42	R:R:W292	9.4	No	No	0	7	5
25	R:R:T86	R:R:V43	4.76	No	No	0	7	6
26	R:R:M299	R:R:T45	6.02	No	No	0	7	4
27	R:R:S46	R:R:T298	6.4	No	No	0	8	9
28	R:R:E78	R:R:N50	9.2	Yes	No	0	9	9
29	R:R:A79	R:R:N50	4.69	No	No	0	7	9
30	R:R:N50	R:R:P302	8.15	No	No	0	9	9
31	R:R:F316	R:R:V52	6.55	Yes	No	0	6	6
32	R:R:F312	R:R:V53	5.24	Yes	No	0	9	8
33	R:R:A59	R:R:W55	7.78	No	Yes	0	4	4
34	R:R:H60	R:R:W55	6.35	No	Yes	0	5	4
35	R:R:H318	R:R:W55	5.29	No	Yes	0	3	4
36	R:R:G315	R:R:I56	5.29	No	No	0	6	8
37	R:R:F316	R:R:I56	6.28	Yes	No	0	6	8
38	R:R:I57	R:R:N68	9.91	No	No	0	7	8
39	R:R:I57	R:R:V72	4.61	No	No	0	7	6
40	R:R:F312	R:R:I57	5.02	Yes	No	0	9	7
41	R:R:L58	R:R:R64	6.07	No	No	0	2	6
42	R:R:R311	R:R:R62	14.93	No	No	0	6	5
43	R:R:F312	R:R:M63	7.46	Yes	No	0	9	7
44	R:R:T65	R:R:T67	4.71	No	No	0	7	8
45	R:R:N68	R:R:T65	5.85	No	No	0	8	7
46	R:R:V66	R:R:Y69	8.83	Yes	No	0	6	5
47	R:R:R141	R:R:V66	9.15	Yes	Yes	3	5	6
48	R:R:T147	R:R:V66	4.76	Yes	Yes	3	7	6
49	R:R:L71	R:R:N68	5.49	No	No	0	8	8
50	R:R:K148	R:R:Y69	5.97	No	No	0	2	5
51	R:R:D129	R:R:F70	14.33	No	Yes	0	9	7
52	R:R:F70	R:R:T147	9.08	Yes	Yes	0	7	7
53	R:R:F70	R:R:V150	6.55	Yes	No	0	7	5
54	R:R:L71	R:R:R130	4.86	No	No	0	8	9
55	R:R:L71	R:R:Y305	8.21	No	No	0	8	9
56	R:R:N73	R:R:S122	8.94	Yes	No	0	9	8
57	R:R:I151	R:R:N73	14.16	No	Yes	0	8	9
58	R:R:N73	R:R:W155	5.65	Yes	Yes	0	9	9
59	R:R:E78	R:R:L74	6.63	Yes	No	2	9	9
60	R:R:L74	R:R:N301	6.87	No	No	2	9	9
61	R:R:F76	R:R:S80	5.28	No	No	0	6	6
62	R:R:F76	R:R:W155	7.02	No	Yes	0	6	9
63	R:R:E78	R:R:T298	11.29	Yes	No	0	9	9
64	R:R:E78	R:R:N301	11.83	Yes	No	2	9	9
65	R:R:F111	R:R:S80	5.28	No	No	0	4	6
66	R:R:M81	R:R:V116	6.09	Yes	No	4	7	7
67	R:R:M81	R:R:W261	4.65	Yes	Yes	4	7	8
68	R:R:M81	R:R:T298	6.02	Yes	No	0	7	9
69	R:R:F111	R:R:F84	8.57	No	No	0	4	5
70	R:R:N85	R:R:N89	5.45	Yes	Yes	1	6	6
71	R:R:H108	R:R:N85	7.65	Yes	Yes	1	5	6
72	R:R:N85	R:R:P112	4.89	Yes	No	1	6	6
73	R:R:M295	R:R:N85	7.01	No	Yes	0	7	6
74	L:L:?12	R:R:N85	10.2	No	Yes	0	0	6
75	R:R:M295	R:R:T86	10.54	No	No	0	7	7
76	R:R:V88	R:R:Y100	11.36	No	Yes	1	5	7
77	R:R:V88	R:R:Y104	7.57	No	Yes	1	5	5
78	R:R:H108	R:R:V88	16.61	Yes	No	1	5	5
79	R:R:H108	R:R:N89	12.75	Yes	Yes	1	5	6
80	R:R:N89	R:R:Y287	8.14	Yes	Yes	1	6	5
81	R:R:M291	R:R:N89	8.41	No	Yes	1	5	6
82	L:L:L10	R:R:N89	6.87	Yes	Yes	1	0	6
83	R:R:T91	R:R:Y100	6.24	No	Yes	0	4	7
84	R:R:N96	R:R:Y92	11.63	Yes	No	0	4	4
85	R:R:W98	R:R:Y92	12.54	Yes	No	0	8	4
86	L:L:L10	R:R:Y92	4.69	Yes	No	0	0	4
87	R:R:H95	R:R:V94	6.92	No	No	0	5	5
88	R:R:E97	R:R:H95	6.15	No	No	0	4	5
89	R:R:N96	R:R:R177	9.64	Yes	Yes	0	4	2
90	L:L:F7	R:R:N96	10.87	Yes	Yes	0	0	4
91	L:L:F8	R:R:N96	9.67	Yes	Yes	0	0	4
92	R:R:E97	R:R:Y99	19.08	No	No	0	4	2
93	R:R:E97	R:R:R177	5.82	No	Yes	0	4	2
94	R:R:W98	R:R:Y100	18.33	Yes	Yes	1	8	7
95	R:R:W98	R:R:Y104	4.82	Yes	Yes	1	8	5
96	R:R:C105	R:R:W98	5.22	No	Yes	1	9	8
97	R:R:C180	R:R:W98	7.84	Yes	Yes	1	9	8
98	R:R:Y100	R:R:Y104	18.86	Yes	Yes	1	7	5
99	R:R:L102	R:R:T171	10.32	No	No	0	3	5
100	R:R:F107	R:R:Y104	13.41	No	Yes	0	4	5
101	R:R:C105	R:R:C180	7.28	No	Yes	1	9	9
102	R:R:K106	R:R:S169	4.59	No	No	0	6	5
103	R:R:F107	R:R:F111	6.43	No	No	0	4	4
104	R:R:H108	R:R:P112	10.68	Yes	No	1	5	6
105	R:R:N109	R:R:S169	5.96	No	No	0	5	5
106	R:R:C180	R:R:N109	4.72	Yes	No	1	9	5
107	L:L:L10	R:R:N109	9.61	Yes	No	1	0	5
108	R:R:F110	R:R:L159	4.87	No	No	0	6	4
109	R:R:I113	R:R:Q165	8.23	Yes	Yes	5	5	6
110	L:L:M11	R:R:I113	5.83	No	Yes	5	0	5
111	L:L:?12	R:R:I113	10.6	No	Yes	0	0	5
112	R:R:V116	R:R:W261	6.13	No	Yes	4	7	8
113	R:R:F117	R:R:L161	17.05	No	No	0	7	5
114	R:R:F117	R:R:I204	11.3	No	No	0	7	6
115	R:R:A118	R:R:W155	9.08	No	Yes	0	7	9
116	R:R:F257	R:R:I120	7.54	Yes	No	0	9	7
117	R:R:I204	R:R:Y121	6.04	No	No	0	6	5
118	R:R:I212	R:R:T124	6.08	No	No	0	8	7
119	R:R:R130	R:R:V126	7.85	No	No	0	9	9
120	R:R:A127	R:R:Y216	6.67	No	Yes	0	9	9
121	R:R:F128	R:R:M132	8.71	No	No	0	5	5
122	R:R:D129	R:R:R141	7.15	No	Yes	0	9	5
123	R:R:R130	R:R:Y216	11.32	No	Yes	0	9	9
124	R:R:I135	R:R:Y131	21.76	Yes	Yes	6	7	8
125	R:R:H136	R:R:Y131	5.44	Yes	Yes	6	6	8
126	R:R:I134	R:R:V219	6.14	No	Yes	0	8	8
127	R:R:H136	R:R:I135	9.28	Yes	Yes	6	6	7
128	R:R:I135	R:R:V218	4.61	Yes	No	0	7	4
129	R:R:R141	R:R:T147	10.35	Yes	Yes	3	5	7
130	R:R:F163	R:R:Y167	7.22	No	No	0	4	4
131	R:R:P164	R:R:Y196	8.34	No	Yes	0	8	6
132	R:R:I182	R:R:Q165	8.23	No	Yes	0	4	6
133	R:R:Q165	R:R:Y196	13.53	Yes	Yes	0	6	6
134	L:L:M11	R:R:Q165	8.16	No	Yes	5	0	6
135	R:R:Y167	R:R:Y168	11.91	No	No	0	4	5
136	R:R:W184	R:R:Y168	4.82	Yes	No	0	5	5
137	R:R:P185	R:R:Y168	15.3	No	No	0	4	5
138	R:R:E183	R:R:T170	15.52	No	No	0	3	4
139	R:R:E172	R:R:M174	5.41	No	No	0	3	1
140	R:R:M174	R:R:P175	5.03	No	No	0	1	2
141	R:R:R177	R:R:S176	11.86	Yes	No	0	2	5
142	R:R:R177	R:R:V179	6.54	Yes	No	0	2	3
143	L:L:F8	R:R:V179	11.8	Yes	No	0	0	3
144	L:L:L10	R:R:C180	4.76	Yes	Yes	1	0	9
145	L:L:F8	R:R:M181	8.71	Yes	No	0	0	4
146	R:R:I182	R:R:W184	12.92	No	Yes	0	4	5
147	R:R:E193	R:R:W184	14.17	No	Yes	0	4	5
148	R:R:W184	R:R:Y196	13.5	Yes	Yes	0	5	6
149	R:R:P185	R:R:Y192	6.95	No	No	0	4	4
150	R:R:H187	R:R:I191	7.95	No	No	0	2	1
151	R:R:I191	R:R:N189	11.33	No	No	0	1	3
152	R:R:E193	R:R:K190	8.1	No	No	0	4	2
153	R:R:E193	R:R:Y272	12.35	No	No	0	4	5
154	R:R:K194	R:R:Y272	13.14	No	No	0	3	5
155	R:R:H197	R:R:Y196	7.62	No	Yes	0	5	6
156	R:R:V200	R:R:Y196	7.57	No	Yes	0	5	6
157	R:R:H197	R:R:Y272	15.24	No	No	0	5	5
158	R:R:H265	R:R:T201	12.32	Yes	No	0	7	6
159	R:R:L269	R:R:T201	7.37	No	No	0	5	6
160	R:R:H265	R:R:I204	5.3	Yes	No	0	7	6
161	R:R:F206	R:R:Y205	8.25	No	Yes	0	4	8
162	R:R:L209	R:R:Y205	4.69	No	Yes	0	6	8
163	R:R:L262	R:R:Y205	10.55	No	Yes	0	5	8
164	R:R:H265	R:R:Y205	7.62	Yes	Yes	0	7	8
165	R:R:F257	R:R:L209	4.87	Yes	No	0	9	6
166	R:R:A258	R:R:L209	4.73	No	No	0	5	6
167	R:R:V218	R:R:Y214	6.31	No	No	0	4	4
168	R:R:M250	R:R:Y216	19.16	Yes	Yes	0	8	9
169	R:R:M250	R:R:V219	6.09	Yes	Yes	0	8	8
170	R:R:R244	R:R:W224	36.99	No	No	0	5	4
171	R:R:V247	R:R:W224	7.36	No	No	0	6	4
172	R:R:K243	R:R:Q239	8.14	No	No	0	7	4
173	R:R:I304	R:R:M249	7.29	No	No	0	8	8
174	R:R:L308	R:R:M249	8.48	No	No	0	7	8
175	R:R:T256	R:R:Y300	18.73	No	No	0	6	5
176	R:R:F257	R:R:W261	7.02	Yes	Yes	0	9	8
177	R:R:F264	R:R:W261	11.02	Yes	Yes	0	7	8
178	R:R:A294	R:R:W261	5.19	No	Yes	0	7	8
179	R:R:S297	R:R:W261	4.94	No	Yes	0	9	8
180	R:R:I266	R:R:L262	5.71	No	No	0	6	5
181	R:R:L293	R:R:P263	4.93	No	No	0	7	9
182	R:R:F264	R:R:H265	5.66	Yes	Yes	0	7	7
183	R:R:F264	R:R:F268	12.86	Yes	No	0	7	6
184	R:R:F264	R:R:I290	5.02	Yes	No	0	7	6
185	R:R:F267	R:R:F268	5.36	Yes	No	0	4	6
186	R:R:F267	R:R:Y278	16.5	Yes	No	0	4	2
187	R:R:F267	R:R:I283	7.54	Yes	No	0	4	4
188	R:R:F267	R:R:Y287	10.32	Yes	Yes	0	4	5
189	R:R:F267	R:R:I290	8.79	Yes	No	0	4	6
190	L:L:M11	R:R:F268	9.95	No	No	0	0	6
191	R:R:L270	R:R:L277	5.54	No	No	0	4	5
192	R:R:L270	R:R:Y278	5.86	No	No	0	4	2
193	R:R:P271	R:R:Y278	11.13	No	No	0	4	2
194	R:R:D276	R:R:N274	5.39	No	Yes	0	1	4
195	R:R:L277	R:R:N274	9.61	No	Yes	0	5	4
196	R:R:F282	R:R:L277	4.87	No	No	0	3	5
197	L:L:Q5	R:R:L279	7.99	No	No	0	0	2
198	R:R:F282	R:R:K280	4.96	No	No	0	3	4
199	R:R:K281	R:R:Q284	5.42	No	Yes	1	2	4
200	R:R:Q284	R:R:Q285	10.24	Yes	Yes	1	4	1
201	L:L:F7	R:R:Q284	7.03	Yes	Yes	1	0	4
202	R:R:M291	R:R:Y287	10.78	No	Yes	1	5	5
203	L:L:F7	R:R:Y287	9.28	Yes	Yes	1	0	5
204	L:L:G9	R:R:Y287	5.79	No	Yes	0	0	5
205	R:R:M291	R:R:M295	5.78	No	No	0	5	7
206	R:R:S296	R:R:Y300	6.36	No	No	0	5	5
207	R:R:I303	R:R:M299	5.83	No	No	0	7	7
208	R:R:N301	R:R:Y305	4.65	No	No	0	9	9
209	R:R:F312	R:R:Y305	19.6	Yes	No	0	9	9
210	R:R:C306	R:R:R313	5.57	No	No	0	7	8
211	R:R:N309	R:R:R311	6.03	No	No	0	8	6
212	R:R:F312	R:R:N309	9.67	Yes	No	0	9	8
213	L:L:K3	L:L:Q5	9.49	No	No	0	0	0
214	L:L:P4	L:L:Q5	6.32	No	No	0	0	0
215	L:L:F8	L:L:Q6	15.23	Yes	No	0	0	0
216	R:R:L142	R:R:T147	4.42	No	Yes	0	6	7
217	R:R:I198	R:R:K194	4.36	No	No	0	5	3
218	R:R:F257	R:R:P208	4.33	Yes	No	0	9	9
219	R:R:M249	R:R:M250	4.33	No	Yes	0	8	8
220	R:R:E78	R:R:S119	4.31	Yes	No	0	9	9
221	R:R:I134	R:R:L223	4.28	No	No	0	8	8
222	R:R:I154	R:R:N73	4.25	No	Yes	0	7	9
223	R:R:I273	R:R:N274	4.25	No	Yes	0	5	4
224	R:R:K243	R:R:L223	4.23	No	No	0	7	8
225	R:R:K317	R:R:L314	4.23	No	No	0	5	4
226	R:R:C306	R:R:F316	4.19	No	Yes	0	7	6
227	R:R:A125	R:R:F70	4.16	No	Yes	0	7	7
228	L:L:K3	L:L:Q6	4.07	No	No	0	0	0
229	R:R:G49	R:R:P302	4.06	No	No	0	8	9
230	R:R:C260	R:R:Y300	4.03	No	No	0	8	5
231	R:R:A215	R:R:Y131	4	No	Yes	0	7	8
232	R:R:H136	R:R:M132	3.94	Yes	No	0	6	5
233	R:R:F316	R:R:V53	3.93	Yes	No	0	6	8
234	R:R:R244	R:R:V240	3.92	No	No	0	5	2
235	R:R:A319	R:R:W55	3.89	No	Yes	0	4	4
236	R:R:A77	R:R:W155	3.89	No	Yes	0	8	9
237	R:R:R141	R:R:T67	3.88	Yes	No	0	5	8
238	R:R:V219	R:R:Y131	3.79	Yes	Yes	0	8	8
239	R:R:F76	R:R:M54	3.73	No	No	0	6	7
240	R:R:G166	R:R:S169	3.71	No	No	0	5	5
241	R:R:K317	R:R:R313	3.71	No	No	0	5	8
242	R:R:G220	R:R:V247	3.68	No	No	0	5	6
243	R:R:T171	R:R:W98	3.64	No	Yes	0	5	8
244	R:R:I212	R:R:Y216	3.63	No	Yes	0	8	9
245	R:R:L203	R:R:Y121	3.52	No	No	0	4	5
246	R:R:A82	R:R:S46	3.42	No	No	0	6	8
247	R:R:A75	R:R:V53	3.39	No	No	0	9	8
248	R:R:A144	R:R:V66	3.39	No	Yes	0	2	6
249	R:R:I290	R:R:P263	3.39	No	No	0	6	9
250	L:L:P4	R:R:M174	3.35	No	No	0	0	1
251	R:R:L207	R:R:P208	3.28	No	No	0	5	9
252	R:R:N189	R:R:P188	3.26	No	No	0	3	1
253	R:R:A162	R:R:I113	3.25	No	Yes	0	7	5
254	R:R:C307	R:R:K245	3.23	No	No	0	6	8
255	R:R:V43	R:R:V87	3.21	No	No	0	6	8
256	R:R:T124	R:R:V211	3.17	No	No	0	7	6
257	R:R:T171	R:R:V178	3.17	No	No	0	5	4
258	R:R:T173	R:R:V178	3.17	No	No	0	2	4
259	R:R:C260	R:R:L293	3.17	No	No	0	8	7
260	R:R:P140	R:R:Q139	3.16	No	No	0	6	4
261	R:R:A93	R:R:L288	3.15	No	No	0	5	3
262	R:R:A146	R:R:L142	3.15	No	No	0	4	6
263	R:R:I191	R:R:V195	3.07	No	No	0	1	4
264	R:R:I283	R:R:V286	3.07	No	No	0	4	5
265	R:R:H187	R:R:P185	3.05	No	No	0	2	4
266	R:R:M54	R:R:V51	3.04	No	No	0	7	4
267	R:R:I135	R:R:T222	3.04	Yes	No	0	7	5
268	R:R:M250	R:R:V246	3.04	Yes	No	0	8	7
269	R:R:L157	R:R:V153	2.98	No	No	0	4	3
270	R:R:L160	R:R:V156	2.98	No	No	0	4	3
271	R:R:L210	R:R:V211	2.98	No	No	0	3	6
272	R:R:I120	R:R:M123	2.92	No	No	0	7	8
273	R:R:K245	R:R:L308	2.82	No	No	0	8	7
274	R:R:G101	R:R:W98	2.81	No	Yes	0	8	8
275	R:R:A36	R:R:F90	2.77	No	No	0	6	6
276	R:R:H60	R:R:I56	2.65	No	No	0	5	8
277	R:R:F206	R:R:V202	2.62	No	No	0	4	4
278	R:R:A38	R:R:W292	2.59	No	No	0	4	5
279	R:R:V253	R:R:Y216	2.52	No	Yes	0	7	9
280	R:R:V254	R:R:Y216	2.52	No	Yes	0	8	9
281	R:R:K61	R:R:R64	2.48	No	No	0	6	6
282	R:R:H136	R:R:Q139	2.47	Yes	No	0	6	4
283	R:R:D310	R:R:R313	2.38	No	No	0	4	8
284	R:R:L34	R:R:W30	2.28	No	No	0	4	1
285	R:R:F110	R:R:F163	2.14	No	No	0	6	4
286	R:R:G49	R:R:V48	1.84	No	No	0	8	4
287	R:R:G213	R:R:V254	1.84	No	No	0	4	8
288	R:R:G220	R:R:V219	1.84	No	Yes	0	5	8
289	R:R:G213	R:R:T217	1.82	No	No	0	4	3
290	R:R:A114	R:R:A158	1.79	No	No	0	5	8
291	R:R:A114	R:R:A162	1.79	No	No	0	5	7
292	R:R:A118	R:R:A158	1.79	No	No	0	7	8
293	R:R:A146	R:R:S143	1.71	No	No	0	4	7
294	R:R:C152	R:R:V156	1.71	No	No	0	3	3
295	R:R:C199	R:R:V195	1.71	No	No	0	4	4
296	R:R:A82	R:R:V47	1.7	No	No	0	6	6
297	R:R:A83	R:R:V47	1.7	No	No	0	4	6
298	R:R:C255	R:R:I259	1.64	No	No	0	4	5
299	R:R:N274	R:R:P275	1.63	Yes	No	0	4	3
300	R:R:A133	R:R:I134	1.62	No	No	0	8	8
301	R:R:A115	R:R:M81	1.61	No	Yes	0	8	7
302	R:R:V44	R:R:V48	1.6	No	No	0	4	4
303	R:R:S143	R:R:T145	1.6	No	No	0	7	4
304	R:R:V149	R:R:V153	1.6	No	No	0	3	3
305	R:R:T40	R:R:V44	1.59	No	No	0	4	4
306	R:R:T45	R:R:V41	1.59	No	No	0	4	5
307	R:R:T145	R:R:V149	1.59	No	No	0	4	3
308	R:R:T256	R:R:V252	1.59	No	No	0	6	5
309	R:R:I251	R:R:V247	1.54	No	No	0	5	6
310	R:R:M299	R:R:S46	1.53	No	No	0	7	8
311	R:R:H136	R:R:P137	1.53	Yes	No	0	6	8
312	R:R:I221	R:R:T217	1.52	No	No	0	3	3
313	R:R:A242	R:R:E238	1.51	No	No	0	5	3
314	R:R:L58	R:R:V72	1.49	No	No	0	2	6
315	R:R:L157	R:R:L160	1.38	No	No	0	4	4
316	R:R:H237	R:R:V240	1.38	No	No	0	2	2
317	R:R:L138	R:R:Q139	1.33	No	No	0	6	4
318	R:R:A289	R:R:W35	1.3	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F25	10.836	5	1	6
2	R:R:Q27	9.075	4	1	4
3	R:R:Q31	9.9325	4	1	2
4	R:R:W55	5.8275	4	0	4
5	R:R:V66	6.5325	4	3	6
6	R:R:F70	8.53	4	0	7
7	R:R:N73	8.25	4	0	9
8	R:R:E78	8.652	5	2	9
9	R:R:M81	4.5925	4	4	7
10	R:R:N85	7.04	5	1	6
11	R:R:N89	8.324	5	1	6
12	R:R:N96	10.4525	4	0	4
13	R:R:W98	7.88571	7	1	8
14	R:R:Y100	13.6975	4	1	7
15	R:R:Y104	11.165	4	1	5
16	R:R:H108	11.9225	4	1	5
17	R:R:I113	6.9775	4	5	5
18	R:R:Y131	8.7475	4	6	8
19	R:R:I135	9.6725	4	6	7
20	R:R:H136	4.532	5	6	6
21	R:R:R141	7.6325	4	3	5
22	R:R:T147	7.1525	4	3	7
23	R:R:W155	6.41	4	0	9
24	R:R:Q165	9.5375	4	5	6
25	R:R:R177	9.664	5	0	2
26	R:R:C180	6.15	4	1	9
27	R:R:W184	11.3525	4	0	5
28	R:R:Y196	10.112	5	0	6
29	R:R:Y205	7.7775	4	0	8
30	R:R:Y216	7.63667	6	0	9
31	R:R:V219	4.465	4	0	8
32	R:R:M250	8.155	4	0	8
33	R:R:F257	5.94	4	0	9
34	R:R:W261	6.49167	6	4	8
35	R:R:F264	8.64	4	0	7
36	R:R:H265	7.725	4	0	7
37	R:R:F267	9.702	5	0	4
38	R:R:N274	5.22	4	0	4
39	R:R:Q284	9.696	5	1	4
40	R:R:Q285	7.7225	4	1	1
41	R:R:Y287	8.862	5	1	5
42	R:R:F312	9.398	5	0	9
43	R:R:F316	5.2375	4	0	6
44	L:L:F7	10.545	4	1	0
45	L:L:F8	11.3525	4	0	0
46	L:L:L10	6.4825	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q284	R:R:Q285	16.9341	10.24	Yes	Yes	1	4	1
2	R:R:Q285	R:R:W35	11.6261	6.57	Yes	No	0	1	4
3	L:L:F7	R:R:Y287	53.4602	9.28	Yes	Yes	1	0	5
4	R:R:F267	R:R:Y287	83.162	10.32	Yes	Yes	0	4	5
5	R:R:F267	R:R:F268	50.0177	5.36	Yes	No	0	4	6
6	R:R:F264	R:R:F268	64.5826	12.86	Yes	No	0	7	6
7	R:R:F264	R:R:W261	100	11.02	Yes	Yes	0	7	8
8	R:R:M81	R:R:W261	96.3803	4.65	Yes	Yes	4	7	8
9	R:R:M81	R:R:T298	95.6918	6.02	Yes	No	0	7	9
10	R:R:F267	R:R:I290	44.0743	8.79	Yes	No	0	4	6
11	R:R:F264	R:R:I290	44.8033	5.02	Yes	No	0	7	6
12	R:R:E78	R:R:T298	91.0393	11.29	Yes	No	0	9	9
13	R:R:E78	R:R:N301	85.0377	11.83	Yes	No	2	9	9
14	R:R:N301	R:R:Y305	84.653	4.65	No	No	0	9	9
15	R:R:F312	R:R:Y305	24.3735	19.6	Yes	No	0	9	9
16	R:R:F312	R:R:V53	16.9924	5.24	Yes	No	0	9	8
17	R:R:F316	R:R:V53	15.0483	3.93	Yes	No	0	6	8
18	R:R:L71	R:R:Y305	64.6155	8.21	No	No	0	8	9
19	R:R:L71	R:R:N68	25.8594	5.49	No	No	0	8	8
20	R:R:N68	R:R:T65	25.9834	5.85	No	No	0	8	7
21	R:R:T65	R:R:T67	24.9962	4.71	No	No	0	7	8
22	R:R:R141	R:R:T67	23.9964	3.88	Yes	No	0	5	8
23	R:R:R141	R:R:T147	14.6864	10.35	Yes	Yes	3	5	7
24	R:R:L71	R:R:R130	45.2919	4.86	No	No	0	8	9
25	L:L:F7	R:R:N96	26.2188	10.87	Yes	Yes	0	0	4
26	R:R:N96	R:R:Y92	10.0694	11.63	Yes	No	0	4	4
27	R:R:W98	R:R:Y92	13.8688	12.54	Yes	No	0	8	4
28	R:R:N89	R:R:Y287	28.4463	8.14	Yes	Yes	1	6	5
29	L:L:L10	R:R:N89	19.8071	6.87	Yes	Yes	1	0	6
30	L:L:F8	R:R:N96	12.7398	9.67	Yes	Yes	0	0	4
31	R:R:T171	R:R:W98	12.836	3.64	No	Yes	0	5	8
32	R:R:W184	R:R:Y168	19.8982	4.82	Yes	No	0	5	5
33	R:R:I182	R:R:W184	12.0539	12.92	No	Yes	0	4	5
34	R:R:I182	R:R:Q165	12.7601	8.23	No	Yes	0	4	6
35	L:L:M11	R:R:Q165	23.8394	8.16	No	Yes	5	0	6
36	L:L:M11	R:R:F268	32.8937	9.95	No	No	0	0	6
37	R:R:W184	R:R:Y196	12.226	13.5	Yes	Yes	0	5	6
38	R:R:Q165	R:R:Y196	17.1999	13.53	Yes	Yes	0	6	6
39	R:R:F264	R:R:H265	15.18	5.66	Yes	Yes	0	7	7
40	R:R:R130	R:R:Y216	43.6972	11.32	No	Yes	0	9	9
41	R:R:V219	R:R:Y131	14.0156	3.79	Yes	Yes	0	8	8
42	R:R:M250	R:R:V219	27.1579	6.09	Yes	Yes	0	8	8
43	R:R:M250	R:R:Y216	33.7544	19.16	Yes	Yes	0	8	9
44	R:R:P185	R:R:Y168	12.3146	15.3	No	No	0	4	5
45	R:R:F267	R:R:Y278	11.697	16.5	Yes	No	0	4	2
46	R:R:L142	R:R:T147	10.806	4.42	No	Yes	0	6	7
47	L:L:F7	R:R:Q284	26.353	7.03	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F25	R:R:N23	8.46	1	Yes	No	6	8	1	2
R:R:N23	R:R:R177	14.46	0	No	Yes	8	2	2	2
R:R:F25	R:R:Q24	14.05	1	Yes	No	6	3	1	2
R:R:K281	R:R:Q24	5.42	1	No	No	2	3	2	2
R:R:F25	R:R:K281	4.96	1	Yes	No	6	2	1	2
R:R:F25	R:R:Q284	11.71	1	Yes	Yes	6	4	1	1
L:L:F7	R:R:F25	15	1	Yes	Yes	0	6	0	1
R:R:Q27	R:R:Q284	14.08	1	Yes	Yes	4	4	2	1
R:R:Q27	R:R:Q285	7.68	1	Yes	Yes	4	1	2	2
R:R:N85	R:R:N89	5.45	1	Yes	Yes	6	6	1	1
R:R:H108	R:R:N85	7.65	1	Yes	Yes	5	6	2	1
R:R:N85	R:R:P112	4.89	1	Yes	No	6	6	1	2
R:R:M295	R:R:N85	7.01	0	No	Yes	7	6	2	1
L:L:?12	R:R:N85	10.2	0	No	Yes	0	6	0	1
R:R:H108	R:R:N89	12.75	1	Yes	Yes	5	6	2	1
R:R:N89	R:R:Y287	8.14	1	Yes	Yes	6	5	1	1
R:R:M291	R:R:N89	8.41	1	No	Yes	5	6	2	1
L:L:L10	R:R:N89	6.87	1	Yes	Yes	0	6	0	1
R:R:N96	R:R:Y92	11.63	0	Yes	No	4	4	1	1
R:R:W98	R:R:Y92	12.54	1	Yes	No	8	4	2	1
L:L:L10	R:R:Y92	4.69	1	Yes	No	0	4	0	1
R:R:N96	R:R:R177	9.64	0	Yes	Yes	4	2	1	2
L:L:F7	R:R:N96	10.87	1	Yes	Yes	0	4	0	1
L:L:F8	R:R:N96	9.67	0	Yes	Yes	0	4	0	1
R:R:C105	R:R:W98	5.22	1	No	Yes	9	8	2	2
R:R:C180	R:R:W98	7.84	1	Yes	Yes	9	8	1	2
R:R:C105	R:R:C180	7.28	1	No	Yes	9	9	2	1
R:R:H108	R:R:P112	10.68	1	Yes	No	5	6	2	2
R:R:N109	R:R:S169	5.96	1	No	No	5	5	1	2
R:R:C180	R:R:N109	4.72	1	Yes	No	9	5	1	1
L:L:L10	R:R:N109	9.61	1	Yes	No	0	5	0	1
R:R:I113	R:R:Q165	8.23	5	Yes	Yes	5	6	1	1
L:L:M11	R:R:I113	5.83	5	No	Yes	0	5	0	1
L:L:?12	R:R:I113	10.6	0	No	Yes	0	5	0	1
R:R:I182	R:R:Q165	8.23	0	No	Yes	4	6	2	1
R:R:Q165	R:R:Y196	13.53	5	Yes	Yes	6	6	1	2
L:L:M11	R:R:Q165	8.16	5	No	Yes	0	6	0	1
R:R:E172	R:R:M174	5.41	0	No	No	3	1	2	1
R:R:M174	R:R:P175	5.03	0	No	No	1	2	1	2
R:R:R177	R:R:V179	6.54	0	Yes	No	2	3	2	1
L:L:F8	R:R:V179	11.8	0	Yes	No	0	3	0	1
L:L:L10	R:R:C180	4.76	1	Yes	Yes	0	9	0	1
L:L:F8	R:R:M181	8.71	0	Yes	No	0	4	0	1
R:R:F264	R:R:F268	12.86	0	Yes	No	7	6	2	1
R:R:F267	R:R:F268	5.36	0	Yes	No	4	6	2	1
R:R:F267	R:R:Y287	10.32	0	Yes	Yes	4	5	2	1
L:L:M11	R:R:F268	9.95	5	No	No	0	6	0	1
L:L:Q5	R:R:L279	7.99	0	No	No	0	2	0	1
R:R:K281	R:R:Q284	5.42	1	No	Yes	2	4	2	1
R:R:Q284	R:R:Q285	10.24	1	Yes	Yes	4	1	1	2
L:L:F7	R:R:Q284	7.03	1	Yes	Yes	0	4	0	1
R:R:M291	R:R:Y287	10.78	1	No	Yes	5	5	2	1
L:L:F7	R:R:Y287	9.28	1	Yes	Yes	0	5	0	1
L:L:G9	R:R:Y287	5.79	0	No	Yes	0	5	0	1
R:R:M291	R:R:M295	5.78	1	No	No	5	7	2	2
L:L:P4	R:R:M174	3.35	0	No	No	0	1	0	1
R:R:A162	R:R:I113	3.25	0	No	Yes	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7P02_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.58
Number of Linked Nodes	288
Number of Links	318
Number of Hubs	46
Number of Links mediated by Hubs	160
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	48
Number Of Links MetaPath	47
Number of Shortest Paths	68229
Length Of Smallest Path	3
Average Path Length	15.3057
Length of Longest Path	35
Minimum Path Strength	1.595
Average Path Strength	8.05775
Maximum Path Strength	22.175
Minimum Path Correlation	0.7
Average Path Correlation	0.926466
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	43.3934
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.533
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • tachykinin receptor activity • neuropeptide receptor activity • substance P receptor activity • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of systemic arterial blood pressure by hormone • regulation of blood volume by renin-angiotensin • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • feeding behavior • brain renin-angiotensin system • behavior • regulation of systemic arterial blood pressure • circulatory system process • endocrine process • drinking behavior • angiotensin-mediated drinking behavior • nervous system process involved in regulation of systemic arterial blood pressure • blood circulation • positive regulation of cell communication • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of transport • positive regulation of signaling • regulation of tube diameter • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • regulation of anatomical structure size • response to steroid hormone • response to progesterone • regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • smooth muscle cell proliferation • regulation of cell motility • regulation of smooth muscle cell migration • smooth muscle cell migration • muscle cell migration • regulation of locomotion • regulation of cell migration • locomotion • excretion • micturition • smooth muscle contraction involved in micturition • urinary bladder smooth muscle contraction • muscle contraction • muscle system process • smooth muscle contraction • urinary tract smooth muscle contraction • multicellular organismal response to stress • response to pain • behavioral response to pain • multi-multicellular organism process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • response to electrical stimulus • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • positive regulation of lymphocyte activation • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • positive regulation of lymphocyte proliferation • mononuclear cell proliferation • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • regulation of lymphocyte activation • regulation of vascular permeability • positive regulation of vascular permeability • tachykinin receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • detection of stimulus • detection of abiotic stimulus • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • trans-synaptic signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of synaptic transmission, GABAergic • response to oxidative stress • response to ozone • response to reactive oxygen species • positive regulation of blood pressure • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of muscle system process • uterine smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • eating behavior • positive regulation of epithelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • response to ethanol • learning or memory • long-term memory • memory • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • positive regulation of locomotion • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of cell migration • positive regulation of cell motility • response to auditory stimulus • response to mechanical stimulus • regulation of reproductive process • regulation of cilium-dependent cell motility • positive regulation of flagellated sperm motility • cilium or flagellum-dependent cell motility • regulation of flagellated sperm motility • cilium-dependent cell motility • positive regulation of cilium movement • positive regulation of reproductive process • sperm motility • positive regulation of cilium-dependent cell motility • regulation of microtubule-based movement • cilium movement involved in cell motility • regulation of cilium movement • flagellated sperm motility • microtubule-based movement • cilium movement • regulation of cilium movement involved in cell motility • aggressive behavior • learning • associative learning • ossification • positive regulation of ossification • regulation of ossification • response to nicotine • operant conditioning • positive regulation of synaptic transmission, cholinergic • synaptic transmission, cholinergic • regulation of synaptic transmission, cholinergic • positive regulation of organelle organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • positive regulation of supramolecular fiber organization • regulation of stress fiber assembly • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • response to estradiol • positive regulation of epithelial cell migration • tissue migration • ameboidal-type cell migration • epithelial cell migration • regulation of epithelial cell migration • epithelium migration • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • 9+2 motile cilium • sperm flagellum • motile cilium • somatodendritic compartment • dendrite • dendritic tree • sperm midpiece • cell body • sperm head • cell surface • substance P receptor binding • neurokinin receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of defense response • regulation of acute inflammatory response • acute inflammatory response • cellular response to growth factor stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • sensory perception of pain • heart process • negative regulation of heart rate • regulation of heart contraction • negative regulation of blood circulation • negative regulation of heart contraction • heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • corticosterone secretion • positive regulation of steroid hormone secretion • regulation of glucocorticoid secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • positive regulation of corticosterone secretion • lipid localization • positive regulation of lipid localization • regulation of lipid localization • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • neuronal cell body • axon
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25103
Sequence	>7P02_nogp_Chain_R P N Q F V Q P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H K R M R T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N E W Y Y G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H P L Q P R L S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S T T E T M P S R V V C M I E W P E H P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N P D L Y L K K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F R L G F K H A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6HLL	A	Peptide	Tachykinin	NK₁	Homo sapiens	CP99994	-	-	3.27	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLO	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.4	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6HLP	A	Peptide	Tachykinin	NK₁	Homo sapiens	Netupitant	-	-	2.2	2019-01-16	doi.org/10.1038/s41467-018-07939-8
	6J20	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	2.7	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	6J21	A	Peptide	Tachykinin	NK₁	Homo sapiens	Aprepitant	-	-	3.2	2019-03-06	doi.org/10.1038/s41467-019-08568-5
	7RMG	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMG (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	Gs/β1/γ2	3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMH (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.1	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(Gs-CtGq)/β1/γ2	3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	7RMI (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		3.2	2021-11-03	doi.org/10.1038/s41589-021-00890-8
	8U26	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	Gs/β1/γ2	2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	8U26 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.5	2023-11-15	doi.org/10.1038/s41592-023-02082-9
	6E59	A	Peptide	Tachykinin	NK₁	Homo sapiens	L-760735	-	-	3.4	2018-12-12	doi.org/10.1073/pnas.1812717115
	7P00	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P00 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Substance-P	-		2.71	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-	chim(NtGi1-Gs)/β1/γ2	2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872
	7P02 (No Gprot)	A	Peptide	Tachykinin	NK₁	Homo sapiens	Protachykinin-1	-		2.87	2021-12-15	doi.org/10.1126/sciadv.abk2872

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