psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C16	L:L:C5	7.28	No	No	0	0	0
2	L:L:F13	L:L:R6	4.28	Yes	No	0	0	0
3	L:L:R6	R:R:S103	3.95	No	No	0	0	4
4	L:L:F8	R:R:Y286	21.66	No	No	0	0	4
5	L:L:F9	L:L:W10	3.01	Yes	Yes	1	0	0
6	L:L:F9	R:R:A188	5.55	Yes	No	1	0	3
7	L:L:F9	R:R:W190	5.01	Yes	Yes	1	0	6
8	L:L:F9	R:R:G198	3.01	Yes	No	1	0	4
9	L:L:F9	R:R:F201	6.43	Yes	Yes	1	0	5
10	L:L:F9	R:R:I202	7.54	Yes	No	0	0	5
11	L:L:K11	L:L:W10	13.92	Yes	Yes	1	0	0
12	L:L:W10	R:R:Q123	6.57	Yes	Yes	1	0	7
13	L:L:W10	R:R:T205	4.85	Yes	Yes	1	0	4
14	L:L:W10	R:R:F264	10.02	Yes	Yes	1	0	7
15	L:L:K11	R:R:Y89	3.58	Yes	Yes	1	0	6
16	L:L:K11	R:R:D119	5.53	Yes	Yes	1	0	6
17	L:L:K11	R:R:F264	8.69	Yes	Yes	1	0	7
18	L:L:K11	R:R:V290	6.07	Yes	No	0	0	5
19	L:L:K11	R:R:Y294	5.97	Yes	Yes	1	0	7
20	L:L:T12	R:R:Q99	11.34	No	Yes	0	0	4
21	L:L:T12	R:R:N187	7.31	No	No	0	0	5
22	L:L:F13	R:R:N100	7.25	Yes	No	0	0	4
23	L:L:F13	R:R:Y286	6.19	Yes	No	0	0	4
24	L:L:S14	R:R:N187	11.92	No	No	0	0	5
25	R:R:L42	R:R:P44	6.57	No	No	0	6	5
26	R:R:L42	R:R:V45	5.96	No	No	0	6	5
27	R:R:P44	R:R:V43	3.53	No	No	0	5	6
28	R:R:L46	R:R:V50	2.98	No	No	3	5	7
29	R:R:I291	R:R:L46	4.28	No	No	3	5	5
30	R:R:L93	R:R:Y47	5.86	Yes	Yes	0	7	7
31	R:R:A97	R:R:Y47	4	No	Yes	0	6	7
32	R:R:F287	R:R:Y47	17.54	No	Yes	0	3	7
33	R:R:V290	R:R:Y47	5.05	No	Yes	0	5	7
34	R:R:I291	R:R:Y47	18.13	No	Yes	0	5	7
35	R:R:L93	R:R:V50	2.98	Yes	No	0	7	7
36	R:R:I291	R:R:V50	9.22	No	No	3	5	7
37	R:R:C51	R:R:L93	7.94	No	Yes	0	6	7
38	R:R:G54	R:R:M90	5.24	No	No	0	8	6
39	R:R:C298	R:R:G54	3.92	No	No	0	8	8
40	R:R:G56	R:R:L55	3.42	No	No	0	4	6
41	R:R:L55	R:R:T59	4.42	No	No	0	6	4
42	R:R:G57	R:R:P301	4.06	No	No	0	8	9
43	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
44	R:R:N58	R:R:V87	5.91	No	No	0	9	7
45	R:R:N58	R:R:P301	6.52	No	No	0	9	9
46	R:R:A83	R:R:V61	3.39	No	No	0	8	9
47	R:R:I62	R:R:L80	4.28	No	Yes	0	7	6
48	R:R:A83	R:R:I62	3.25	No	No	0	8	7
49	R:R:R67	R:R:Y63	18.52	No	No	4	4	4
50	R:R:F68	R:R:Y63	7.22	Yes	No	4	5	4
51	R:R:F311	R:R:V64	9.18	Yes	Yes	0	8	7
52	R:R:F315	R:R:V64	3.93	No	Yes	0	6	7
53	R:R:M71	R:R:V65	3.04	No	No	0	7	7
54	R:R:L80	R:R:V65	5.96	Yes	No	0	6	7
55	R:R:L66	R:R:M71	4.24	No	No	0	3	7
56	R:R:L66	R:R:L80	6.92	No	Yes	0	3	6
57	R:R:F68	R:R:R67	9.62	Yes	No	4	5	4
58	R:R:A69	R:R:S314	3.42	No	No	0	5	5
59	R:R:N76	R:R:T73	10.24	No	No	0	8	7
60	R:R:V74	R:R:Y78	6.31	No	Yes	1	6	7
61	R:R:D136	R:R:V74	4.38	No	No	1	8	6
62	R:R:A156	R:R:V74	5.09	No	No	1	7	6
63	R:R:I79	R:R:T75	3.04	No	No	0	8	7
64	R:R:A156	R:R:I77	3.25	No	No	0	7	6
65	R:R:V132	R:R:Y78	8.83	No	Yes	0	7	7
66	R:R:M133	R:R:Y78	4.79	Yes	Yes	1	8	7
67	R:R:D136	R:R:Y78	11.49	No	Yes	1	8	7
68	R:R:A156	R:R:Y78	6.67	No	Yes	1	7	7
69	R:R:L80	R:R:V84	2.98	Yes	No	0	6	6
70	R:R:N81	R:R:S160	10.43	No	No	0	9	8
71	R:R:D86	R:R:L82	9.5	Yes	Yes	1	9	9
72	R:R:C129	R:R:L82	3.17	No	Yes	0	8	9
73	R:R:L130	R:R:L82	5.54	No	Yes	1	9	9
74	R:R:L82	R:R:N300	4.12	Yes	Yes	1	9	9
75	R:R:L82	R:R:Y304	3.52	Yes	Yes	1	9	9
76	R:R:L88	R:R:V84	2.98	No	No	0	7	6
77	R:R:D86	R:R:S297	8.83	Yes	No	0	9	9
78	R:R:D86	R:R:N300	12.12	Yes	Yes	1	9	9
79	R:R:L88	R:R:N122	8.24	No	No	0	7	8
80	R:R:L88	R:R:W164	3.42	No	No	0	7	9
81	R:R:D119	R:R:Y89	16.09	Yes	Yes	1	6	6
82	R:R:N122	R:R:Y89	4.65	No	Yes	0	8	6
83	R:R:Q123	R:R:Y89	10.15	Yes	Yes	1	7	6
84	R:R:Y294	R:R:Y89	18.86	Yes	Yes	1	7	6
85	R:R:S297	R:R:Y89	6.36	No	Yes	0	9	6
86	R:R:L93	R:R:M90	4.24	Yes	No	0	7	6
87	R:R:L93	R:R:Y294	15.24	Yes	Yes	0	7	7
88	R:R:F95	R:R:W105	3.01	No	Yes	2	6	8
89	R:R:F107	R:R:F95	12.86	Yes	No	2	7	6
90	R:R:F95	R:R:V115	6.55	No	No	0	6	5
91	R:R:L96	R:R:Y294	4.69	No	Yes	0	6	7
92	R:R:P106	R:R:T98	3.5	No	No	0	3	4
93	R:R:F107	R:R:T98	6.49	Yes	No	0	7	4
94	R:R:Q99	R:R:W105	17.52	Yes	Yes	2	4	8
95	R:R:Q99	R:R:T185	8.5	Yes	No	0	4	4
96	R:R:C186	R:R:Q99	6.1	Yes	Yes	2	9	4
97	R:R:F287	R:R:N100	24.17	No	No	0	3	4
98	R:R:F104	R:R:P106	8.67	No	No	0	4	3
99	R:R:F107	R:R:W105	20.04	Yes	Yes	2	7	8
100	R:R:C112	R:R:W105	6.53	Yes	Yes	2	9	8
101	R:R:Q181	R:R:W105	13.14	No	Yes	2	1	8
102	R:R:C186	R:R:W105	10.45	Yes	Yes	2	9	8
103	R:R:F107	R:R:L111	6.09	Yes	No	0	7	5
104	R:R:G108	R:R:P109	4.06	No	No	0	8	3
105	R:R:L111	R:R:V110	2.98	No	No	0	5	2
106	R:R:C112	R:R:D179	3.11	Yes	Yes	0	9	4
107	R:R:C112	R:R:Q181	3.05	Yes	No	2	9	1
108	R:R:C112	R:R:C186	7.28	Yes	Yes	2	9	9
109	R:R:D179	R:R:R113	4.76	Yes	No	0	4	6
110	R:R:D179	R:R:M116	12.48	Yes	No	0	4	5
111	R:R:C186	R:R:M116	3.24	Yes	No	0	9	5
112	R:R:L175	R:R:T117	8.84	No	No	0	5	6
113	R:R:D119	R:R:G120	3.35	Yes	No	0	6	5
114	R:R:D119	R:R:Y294	5.75	Yes	Yes	1	6	7
115	R:R:S167	R:R:V121	3.23	Yes	No	0	7	5
116	R:R:L168	R:R:V121	2.98	No	No	0	4	5
117	R:R:S171	R:R:V121	6.46	No	No	0	7	5
118	R:R:F124	R:R:Q123	7.03	Yes	Yes	1	6	7
119	R:R:Q123	R:R:W261	12.05	Yes	Yes	1	7	8
120	R:R:F265	R:R:Q123	3.51	Yes	Yes	1	7	7
121	R:R:F124	R:R:F128	3.22	Yes	Yes	1	6	5
122	R:R:F124	R:R:S167	3.96	Yes	Yes	1	6	7
123	R:R:F124	R:R:M170	14.93	Yes	Yes	1	6	4
124	R:R:F124	R:R:S171	3.96	Yes	No	0	6	7
125	R:R:F124	R:R:T205	3.89	Yes	Yes	1	6	4
126	R:R:T125	R:R:W164	19.41	No	No	0	7	9
127	R:R:S167	R:R:T125	6.4	Yes	No	0	7	7
128	R:R:P213	R:R:V127	3.53	Yes	No	0	8	8
129	R:R:V127	R:R:W261	3.68	No	Yes	0	8	8
130	R:R:A163	R:R:F128	4.16	No	Yes	0	6	5
131	R:R:F128	R:R:L166	13.4	Yes	No	0	5	4
132	R:R:F128	R:R:S167	7.93	Yes	Yes	1	5	7
133	R:R:F128	R:R:M170	3.73	Yes	Yes	1	5	4
134	R:R:L130	R:R:N300	6.87	No	Yes	1	9	9
135	R:R:L130	R:R:Y304	5.86	No	Yes	1	9	9
136	R:R:P213	R:R:T131	3.5	Yes	No	0	8	7
137	R:R:I217	R:R:T131	3.04	No	No	0	8	7
138	R:R:A159	R:R:V132	3.39	No	No	0	5	7
139	R:R:M133	R:R:R137	3.72	Yes	No	1	8	9
140	R:R:M133	R:R:Y304	4.79	Yes	Yes	1	8	9
141	R:R:I217	R:R:S134	9.29	No	No	0	8	9
142	R:R:S134	R:R:Y221	6.36	No	Yes	0	9	9
143	R:R:L139	R:R:V135	2.98	No	No	0	5	6
144	R:R:D136	R:R:R151	15.48	No	No	0	8	6
145	R:R:R137	R:R:Y221	6.17	No	Yes	1	9	9
146	R:R:R137	R:R:Y304	8.23	No	Yes	1	9	9
147	R:R:V142	R:R:Y138	12.62	No	Yes	5	7	8
148	R:R:H143	R:R:Y138	6.53	Yes	Yes	5	7	8
149	R:R:C220	R:R:Y138	6.72	No	Yes	0	8	8
150	R:R:L223	R:R:Y138	8.21	No	Yes	0	4	8
151	R:R:I224	R:R:Y138	3.63	No	Yes	0	8	8
152	R:R:L139	R:R:S147	3	No	No	0	5	5
153	R:R:A140	R:R:R151	5.53	No	No	0	8	6
154	R:R:V141	R:R:V142	3.21	No	No	0	8	7
155	R:R:I224	R:R:V141	13.83	No	No	0	8	8
156	R:R:H143	R:R:V142	6.92	Yes	No	5	7	7
157	R:R:R151	R:R:S147	5.27	No	No	0	6	5
158	R:R:R152	R:R:V155	3.92	No	No	0	6	4
159	R:R:K157	R:R:P153	3.35	No	No	0	3	2
160	R:R:M170	R:R:Y204	9.58	Yes	No	1	4	3
161	R:R:F201	R:R:L174	10.96	Yes	No	0	5	3
162	R:R:F177	R:R:V176	13.11	No	No	0	4	4
163	R:R:A178	R:R:D179	4.63	No	Yes	0	5	4
164	R:R:S189	R:R:V180	3.23	No	No	0	1	5
165	R:R:C186	R:R:Q181	3.05	Yes	No	2	9	1
166	R:R:A188	R:R:W190	6.48	No	Yes	1	3	6
167	R:R:P191	R:R:W190	4.05	No	Yes	1	4	6
168	R:R:W190	R:R:W197	9.37	Yes	No	1	6	3
169	R:R:G198	R:R:W190	8.44	No	Yes	1	4	6
170	R:R:F201	R:R:W190	10.02	Yes	Yes	1	5	6
171	R:R:P191	R:R:W197	17.57	No	No	1	4	3
172	R:R:P193	R:R:W197	4.05	No	No	0	4	3
173	R:R:F201	R:R:Y204	7.22	Yes	No	1	5	3
174	R:R:F201	R:R:T205	7.78	Yes	Yes	1	5	4
175	R:R:I202	R:R:L272	8.56	No	No	0	5	4
176	R:R:T205	R:R:Y204	9.99	Yes	No	1	4	3
177	R:R:A206	R:R:F265	5.55	No	Yes	0	4	7
178	R:R:L208	R:R:V207	4.47	No	No	0	4	5
179	R:R:F210	R:R:F211	10.72	Yes	No	0	8	5
180	R:R:F210	R:R:L214	3.65	Yes	No	1	8	7
181	R:R:F210	R:R:F257	3.22	Yes	Yes	1	8	9
182	R:R:F210	R:R:L262	7.31	Yes	No	0	8	5
183	R:R:F210	R:R:F265	5.36	Yes	Yes	1	8	7
184	R:R:C218	R:R:L214	3.17	No	No	0	4	7
185	R:R:F257	R:R:L214	3.65	Yes	No	1	9	7
186	R:R:V250	R:R:Y221	5.05	No	Yes	1	7	9
187	R:R:L253	R:R:Y221	9.38	Yes	Yes	1	8	9
188	R:R:Y221	R:R:Y304	4.96	Yes	Yes	1	9	9
189	R:R:R229	R:R:V225	5.23	No	No	0	4	5
190	R:R:V225	R:R:V250	4.81	No	No	1	5	7
191	R:R:V228	R:R:V246	4.81	No	No	0	8	7
192	R:R:E243	R:R:R229	4.65	Yes	No	0	6	4
193	R:R:E243	R:R:R240	15.12	Yes	No	0	6	3
194	R:R:E243	R:R:T247	7.06	Yes	No	0	6	6
195	R:R:R248	R:R:T247	7.76	No	No	0	5	6
196	R:R:L251	R:R:R248	6.07	No	No	0	4	5
197	R:R:L253	R:R:M249	5.65	Yes	No	0	8	8
198	R:R:L307	R:R:M249	5.65	No	No	0	6	8
199	R:R:L253	R:R:L303	4.15	Yes	No	0	8	8
200	R:R:L253	R:R:Y304	5.86	Yes	Yes	1	8	9
201	R:R:L303	R:R:V256	4.47	No	No	0	8	6
202	R:R:F257	R:R:W261	12.03	Yes	Yes	1	9	8
203	R:R:F257	R:R:N296	3.62	Yes	Yes	1	9	9
204	R:R:C260	R:R:N296	3.15	No	Yes	0	8	9
205	R:R:F265	R:R:W261	3.01	Yes	Yes	1	7	8
206	R:R:S293	R:R:W261	8.65	No	Yes	0	7	8
207	R:R:N296	R:R:W261	18.08	Yes	Yes	1	9	8
208	R:R:L262	R:R:P263	3.28	No	No	0	5	9
209	R:R:P263	R:R:V289	3.53	No	Yes	0	9	7
210	R:R:L292	R:R:P263	3.28	No	No	0	7	9
211	R:R:F264	R:R:F265	10.72	Yes	Yes	1	7	7
212	R:R:F264	R:R:N268	12.08	Yes	No	0	7	5
213	R:R:F264	R:R:S293	3.96	Yes	No	0	7	7
214	R:R:V267	R:R:V289	3.21	No	Yes	0	5	7
215	R:R:L276	R:R:N271	6.87	Yes	No	0	1	4
216	R:R:L276	R:R:P277	4.93	Yes	No	0	1	3
217	R:R:L276	R:R:Y286	8.21	Yes	No	0	1	4
218	R:R:P277	R:R:S282	3.56	No	No	0	3	5
219	R:R:E279	R:R:Q278	5.1	Yes	No	0	2	1
220	R:R:E279	R:R:P280	6.29	Yes	No	0	2	1
221	R:R:L285	R:R:S282	4.5	No	No	0	5	5
222	R:R:L285	R:R:V289	2.98	No	Yes	0	5	7
223	R:R:N296	R:R:N300	10.9	Yes	Yes	1	9	9
224	R:R:L303	R:R:V302	2.98	No	No	0	8	7
225	R:R:F306	R:R:V302	3.93	No	No	0	7	7
226	R:R:F311	R:R:G305	4.52	Yes	No	0	8	7
227	R:R:F306	R:R:F311	5.36	No	Yes	0	7	8
228	R:R:D309	R:R:R312	7.15	No	No	0	5	8
229	R:R:Q313	R:R:Q316	3.84	No	No	0	4	4
230	R:R:N76	R:R:V65	2.96	No	No	0	8	7
231	R:R:L262	R:R:T266	2.95	No	No	0	5	6
232	R:R:I79	R:R:M133	2.92	No	Yes	0	8	8
233	R:R:F201	R:R:P173	2.89	Yes	No	0	5	7
234	R:R:P153	R:R:R152	2.88	No	No	0	2	6
235	R:R:K70	R:R:K72	2.87	No	No	0	5	6
236	R:R:I77	R:R:N81	2.83	No	No	0	6	9
237	R:R:L208	R:R:M170	2.83	No	Yes	0	4	4
238	R:R:G108	R:R:W105	2.81	No	Yes	0	8	8
239	L:L:F13	R:R:A283	2.77	Yes	No	0	0	4
240	R:R:L46	R:R:L49	2.77	No	No	0	5	5
241	R:R:D309	R:R:N310	2.69	No	No	0	5	6
242	R:R:F311	R:R:S308	2.64	Yes	No	0	8	8
243	R:R:D309	R:R:Q313	2.61	No	No	0	5	4
244	L:L:T12	R:R:F287	2.59	No	No	0	0	3
245	R:R:V43	R:R:Y47	2.52	No	Yes	0	6	7
246	R:R:V254	R:R:Y221	2.52	No	Yes	0	7	9
247	R:R:F211	R:R:I269	2.51	No	No	0	5	6
248	R:R:F68	R:R:K317	2.48	Yes	No	0	5	4
249	R:R:S126	R:R:W261	2.47	No	Yes	0	9	8
250	R:R:F306	R:R:L60	2.44	No	No	0	7	6
251	R:R:L175	R:R:R113	2.43	No	No	0	5	6
252	L:L:R6	R:R:E279	2.33	No	Yes	0	0	2
253	R:R:G56	R:R:G57	2.11	No	No	0	4	8
254	R:R:G183	R:R:G184	2.11	No	No	0	1	4
255	R:R:G92	R:R:P94	2.03	No	No	0	6	8
256	R:R:G209	R:R:P213	2.03	No	Yes	0	5	8
257	R:R:F177	R:R:W190	2	No	Yes	0	4	6
258	R:R:A53	R:R:G54	1.95	No	No	0	5	8
259	R:R:A231	R:R:G232	1.95	No	No	0	5	4
260	R:R:A258	R:R:G259	1.95	No	No	0	5	5
261	R:R:A283	R:R:G284	1.95	No	No	0	4	1
262	R:R:C51	R:R:P94	1.88	No	No	0	6	8
263	R:R:A101	R:R:P44	1.87	No	No	0	4	5
264	R:R:A212	R:R:P213	1.87	No	Yes	0	5	8
265	R:R:A281	R:R:P277	1.87	No	No	0	1	3
266	R:R:G195	R:R:V194	1.84	No	No	0	3	2
267	R:R:G184	R:R:T185	1.82	No	No	0	4	4
268	R:R:A295	R:R:C260	1.81	No	No	0	5	8
269	R:R:C220	R:R:S134	1.72	No	No	0	8	9
270	R:R:A85	R:R:S126	1.71	No	No	0	8	9
271	R:R:C169	R:R:V165	1.71	No	No	0	3	5
272	R:R:C220	R:R:V216	1.71	No	No	0	8	7
273	R:R:A69	R:R:V64	1.7	No	Yes	0	5	7
274	R:R:L145	R:R:P144	1.64	No	No	0	5	7
275	R:R:L172	R:R:P173	1.64	No	No	0	5	7
276	R:R:L196	R:R:P193	1.64	No	No	0	1	4
277	L:L:S15	R:R:T185	1.6	No	No	0	0	4
278	R:R:V225	R:R:V246	1.6	No	No	1	5	7
279	R:R:V246	R:R:V250	1.6	No	No	1	7	7
280	R:R:V252	R:R:V256	1.6	No	No	0	6	6
281	R:R:V270	R:R:V274	1.6	No	No	0	5	4
282	R:R:A199	R:R:L272	1.58	No	No	0	3	4
283	R:R:E192	R:R:P193	1.57	No	No	0	3	4
284	R:R:H143	R:R:P144	1.53	Yes	No	0	7	7
285	L:L:C5	R:R:E279	1.52	No	Yes	0	0	2
286	L:L:N7	L:L:S14	1.49	No	No	0	0	0
287	R:R:L91	R:R:V87	1.49	No	No	0	4	7
288	R:R:L114	R:R:V110	1.49	No	No	0	5	2
289	R:R:L255	R:R:V254	1.49	No	No	0	4	7
290	R:R:L276	R:R:V270	1.49	Yes	No	0	1	5
291	R:R:N310	R:R:S308	1.49	No	No	0	6	8
292	R:R:I77	R:R:K157	1.45	No	No	0	6	3
293	R:R:E182	R:R:V180	1.43	No	No	0	4	5
294	R:R:H143	R:R:S146	1.39	Yes	No	0	7	4
295	R:R:L215	R:R:L219	1.38	No	No	0	3	4
296	R:R:L118	R:R:N122	1.37	No	No	0	5	8
297	R:R:F68	R:R:V64	1.31	Yes	Yes	0	5	7
298	R:R:R113	R:R:V180	1.31	No	No	0	6	5
299	R:R:R229	R:R:V226	1.31	No	No	0	4	3
300	R:R:F288	R:R:V289	1.31	No	Yes	0	4	7
301	R:R:V155	R:R:W150	1.23	No	No	0	4	4
302	R:R:V194	R:R:W190	1.23	No	Yes	0	2	6
303	R:R:E243	R:R:R244	1.16	Yes	No	0	6	4
304	R:R:R149	R:R:R152	1.07	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F9	5.09167	6	1	0
2	L:L:W10	7.674	5	1	0
3	L:L:K11	7.29333	6	1	0
4	L:L:F13	5.1225	4	0	0
5	R:R:Y47	8.85	6	0	7
6	R:R:V64	4.03	4	0	7
7	R:R:F68	5.1575	4	4	5
8	R:R:Y78	7.618	5	1	7
9	R:R:L80	5.035	4	0	6
10	R:R:L82	5.17	5	1	9
11	R:R:D86	9.295	4	1	9
12	R:R:Y89	9.94833	6	1	6
13	R:R:L93	7.252	5	0	7
14	R:R:Q99	10.865	4	2	4
15	R:R:W105	10.5	7	2	8
16	R:R:F107	11.37	4	2	7
17	R:R:C112	4.9925	4	2	9
18	R:R:D119	7.68	4	1	6
19	R:R:Q123	7.862	5	1	7
20	R:R:F124	6.165	6	1	6
21	R:R:F128	6.488	5	1	5
22	R:R:M133	4.055	4	1	8
23	R:R:Y138	7.542	5	5	8
24	R:R:H143	4.0925	4	5	7
25	R:R:S167	5.38	4	1	7
26	R:R:M170	7.7675	4	1	4
27	R:R:D179	6.245	4	0	4
28	R:R:C186	6.024	5	2	9
29	R:R:W190	5.825	8	1	6
30	R:R:F201	7.55	6	1	5
31	R:R:T205	6.6275	4	1	4
32	R:R:F210	6.052	5	1	8
33	R:R:P213	2.7325	4	0	8
34	R:R:Y221	5.74	6	1	9
35	R:R:E243	6.9975	4	0	6
36	R:R:L253	6.26	4	1	8
37	R:R:F257	5.63	4	1	9
38	R:R:W261	8.56714	7	1	8
39	R:R:F264	9.094	5	1	7
40	R:R:F265	5.63	5	1	7
41	R:R:L276	5.375	4	0	1
42	R:R:E279	3.81	4	0	2
43	R:R:V289	2.7575	4	0	7
44	R:R:Y294	10.102	5	1	7
45	R:R:N296	8.9375	4	1	9
46	R:R:N300	8.5025	4	1	9
47	R:R:Y304	5.53667	6	1	9
48	R:R:F311	5.425	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F13	L:L:R6	11.9813	4.28	Yes	No	0	0	0
2	L:L:F13	R:R:Y286	11.1957	6.19	Yes	No	0	0	4
3	L:L:F13	R:R:N100	27.0204	7.25	Yes	No	0	0	4
4	R:R:F287	R:R:N100	28.4401	24.17	No	No	0	3	4
5	R:R:F287	R:R:Y47	100	17.54	No	Yes	0	3	7
6	R:R:V290	R:R:Y47	68.259	5.05	No	Yes	0	5	7
7	L:L:K11	R:R:V290	68.8508	6.07	Yes	No	0	0	5
8	L:L:K11	L:L:W10	29.5709	13.92	Yes	Yes	1	0	0
9	L:L:F9	L:L:W10	33.4778	3.01	Yes	Yes	1	0	0
10	L:L:F9	R:R:W190	17.0119	5.01	Yes	Yes	1	0	6
11	L:L:W10	R:R:T205	14.8277	4.85	Yes	Yes	1	0	4
12	R:R:F201	R:R:T205	11.1957	7.78	Yes	Yes	1	5	4
13	R:R:L93	R:R:Y47	40.8229	5.86	Yes	Yes	0	7	7
14	R:R:L93	R:R:Y294	46.6568	15.24	Yes	Yes	0	7	7
15	R:R:Y294	R:R:Y89	44.6452	18.86	Yes	Yes	1	7	6
16	R:R:Q123	R:R:Y89	34.4994	10.15	Yes	Yes	1	7	6
17	L:L:K11	R:R:Y89	47.0443	3.58	Yes	Yes	1	0	6
18	L:L:W10	R:R:Q123	32.8472	6.57	Yes	Yes	1	0	7
19	L:L:K11	R:R:F264	12.5379	8.69	Yes	Yes	1	0	7
20	L:L:T12	R:R:F287	78.9333	2.59	No	No	0	0	3
21	L:L:T12	R:R:Q99	73.5574	11.34	No	Yes	0	0	4
22	R:R:S297	R:R:Y89	81.6001	6.36	No	Yes	0	9	6
23	R:R:D86	R:R:S297	80.8849	8.83	Yes	No	0	9	9
24	R:R:D86	R:R:N58	10.9033	6.73	Yes	No	0	9	9
25	R:R:N122	R:R:Y89	20.5136	4.65	No	Yes	0	8	6
26	R:R:L88	R:R:N122	17.9419	8.24	No	No	0	7	8
27	R:R:L88	R:R:V84	15.5746	2.98	No	No	0	7	6
28	R:R:L80	R:R:V84	14.1936	2.98	Yes	No	0	6	6
29	R:R:D86	R:R:L82	73.6596	9.5	Yes	Yes	1	9	9
30	R:R:L82	R:R:Y304	91.6332	3.52	Yes	Yes	1	9	9
31	R:R:L253	R:R:Y304	41.1118	5.86	Yes	Yes	1	8	9
32	R:R:L253	R:R:L303	39.213	4.15	Yes	No	0	8	8
33	R:R:L303	R:R:V302	34.0132	2.98	No	No	0	8	7
34	R:R:F306	R:R:V302	32.2589	3.93	No	No	0	7	7
35	R:R:F306	R:R:F311	28.9861	5.36	No	Yes	0	7	8
36	R:R:F311	R:R:V64	14.5847	9.18	Yes	Yes	0	8	7
37	R:R:M133	R:R:Y304	40.5376	4.79	Yes	Yes	1	8	9
38	R:R:M133	R:R:Y78	37.9307	4.79	Yes	Yes	1	8	7
39	R:R:D136	R:R:Y78	11.8051	11.49	No	Yes	1	8	7
40	R:R:A156	R:R:Y78	19.0058	6.67	No	Yes	1	7	7
41	R:R:A156	R:R:I77	17.2973	3.25	No	No	0	7	6
42	R:R:L130	R:R:N300	21.0843	6.87	No	Yes	1	9	9
43	R:R:Q99	R:R:W105	34.9503	17.52	Yes	Yes	2	4	8
44	R:R:F107	R:R:W105	11.4881	20.04	Yes	Yes	2	7	8
45	R:R:C186	R:R:Q99	31.4838	6.1	Yes	Yes	2	9	4
46	R:R:C112	R:R:W105	14.6762	6.53	Yes	Yes	2	9	8
47	R:R:C112	R:R:C186	14.331	7.28	Yes	Yes	2	9	9
48	R:R:C112	R:R:D179	25.8437	3.11	Yes	Yes	0	9	4
49	R:R:C186	R:R:M116	14.2288	3.24	Yes	No	0	9	5
50	R:R:D179	R:R:M116	12.7633	12.48	Yes	No	0	4	5
51	R:R:D179	R:R:R113	28.9967	4.76	Yes	No	0	4	6
52	R:R:F124	R:R:Q123	32.6605	7.03	Yes	Yes	1	6	7
53	R:R:F124	R:R:T205	11.0089	3.89	Yes	Yes	1	6	4
54	R:R:Q123	R:R:W261	39.1566	12.05	Yes	Yes	1	7	8
55	R:R:F264	R:R:F265	10.5263	10.72	Yes	Yes	1	7	7
56	R:R:V127	R:R:W261	15.7895	3.68	No	Yes	0	8	8
57	R:R:P213	R:R:V127	13.8096	3.53	Yes	No	0	8	8
58	R:R:Y221	R:R:Y304	37.0993	4.96	Yes	Yes	1	9	9
59	R:R:S134	R:R:Y221	17.3114	6.36	No	Yes	0	9	9
60	R:R:D136	R:R:R151	10.0543	15.48	No	No	0	8	6
61	R:R:C220	R:R:S134	18.7663	1.72	No	No	0	8	9
62	R:R:C220	R:R:Y138	15.7084	6.72	No	Yes	0	8	8
63	R:R:I77	R:R:K157	11.4106	1.45	No	No	0	6	3
64	R:R:R113	R:R:V180	14.5283	1.31	No	No	0	6	5
65	R:R:F210	R:R:F265	11.2732	5.36	Yes	Yes	1	8	7
66	R:R:F210	R:R:F257	12.5238	3.22	Yes	Yes	1	8	9
67	R:R:P263	R:R:V289	12.1715	3.53	No	Yes	0	9	7
68	R:R:L262	R:R:P263	14.9546	3.28	No	No	0	5	9
69	R:R:V250	R:R:Y221	22.3843	5.05	No	Yes	1	7	9
70	R:R:V225	R:R:V250	16.9696	4.81	No	No	1	5	7
71	R:R:R229	R:R:V225	15.1342	5.23	No	No	0	4	5
72	R:R:E243	R:R:R229	11.3225	4.65	Yes	No	0	6	4
73	R:R:N296	R:R:W261	32.6992	18.08	Yes	Yes	1	9	8
74	R:R:F311	R:R:S308	11.178	2.64	Yes	No	0	8	8
75	R:R:F210	R:R:L262	17.7235	7.31	Yes	No	0	8	5
76	R:R:F257	R:R:N296	12.5661	3.62	Yes	Yes	1	9	9
77	R:R:N296	R:R:N300	41.8446	10.9	Yes	Yes	1	9	9
78	R:R:L82	R:R:N300	20.6792	4.12	Yes	Yes	1	9	9
79	R:R:L130	R:R:Y304	20.3551	5.86	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R6	R:R:S103	3.95	0	No	No	0	4	0	1
L:L:F8	R:R:Y286	21.66	0	No	No	0	4	0	1
L:L:F9	R:R:A188	5.55	1	Yes	No	0	3	0	1
L:L:F9	R:R:W190	5.01	1	Yes	Yes	0	6	0	1
L:L:F9	R:R:G198	3.01	1	Yes	No	0	4	0	1
L:L:F9	R:R:F201	6.43	1	Yes	Yes	0	5	0	1
L:L:F9	R:R:I202	7.54	1	Yes	No	0	5	0	1
L:L:W10	R:R:Q123	6.57	1	Yes	Yes	0	7	0	1
L:L:W10	R:R:T205	4.85	1	Yes	Yes	0	4	0	1
L:L:W10	R:R:F264	10.02	1	Yes	Yes	0	7	0	1
L:L:K11	R:R:Y89	3.58	1	Yes	Yes	0	6	0	1
L:L:K11	R:R:D119	5.53	1	Yes	Yes	0	6	0	1
L:L:K11	R:R:F264	8.69	1	Yes	Yes	0	7	0	1
L:L:K11	R:R:V290	6.07	1	Yes	No	0	5	0	1
L:L:K11	R:R:Y294	5.97	1	Yes	Yes	0	7	0	1
L:L:T12	R:R:Q99	11.34	0	No	Yes	0	4	0	1
L:L:T12	R:R:N187	7.31	0	No	No	0	5	0	1
L:L:F13	R:R:N100	7.25	0	Yes	No	0	4	0	1
L:L:F13	R:R:Y286	6.19	0	Yes	No	0	4	0	1
L:L:S14	R:R:N187	11.92	0	No	No	0	5	0	1
R:R:L93	R:R:Y47	5.86	0	Yes	Yes	7	7	2	2
R:R:F287	R:R:Y47	17.54	0	No	Yes	3	7	1	2
R:R:V290	R:R:Y47	5.05	0	No	Yes	5	7	1	2
R:R:D119	R:R:Y89	16.09	1	Yes	Yes	6	6	1	1
R:R:N122	R:R:Y89	4.65	0	No	Yes	8	6	2	1
R:R:Q123	R:R:Y89	10.15	1	Yes	Yes	7	6	1	1
R:R:Y294	R:R:Y89	18.86	1	Yes	Yes	7	6	1	1
R:R:S297	R:R:Y89	6.36	0	No	Yes	9	6	2	1
R:R:L93	R:R:Y294	15.24	0	Yes	Yes	7	7	2	1
R:R:L96	R:R:Y294	4.69	0	No	Yes	6	7	2	1
R:R:Q99	R:R:W105	17.52	2	Yes	Yes	4	8	1	2
R:R:Q99	R:R:T185	8.5	2	Yes	No	4	4	1	1
R:R:C186	R:R:Q99	6.1	2	Yes	Yes	9	4	2	1
R:R:F287	R:R:N100	24.17	0	No	No	3	4	1	1
R:R:C186	R:R:W105	10.45	2	Yes	Yes	9	8	2	2
R:R:D119	R:R:G120	3.35	1	Yes	No	6	5	1	2
R:R:D119	R:R:Y294	5.75	1	Yes	Yes	6	7	1	1
R:R:F124	R:R:Q123	7.03	1	Yes	Yes	6	7	2	1
R:R:Q123	R:R:W261	12.05	1	Yes	Yes	7	8	1	2
R:R:F265	R:R:Q123	3.51	1	Yes	Yes	7	7	2	1
R:R:F124	R:R:T205	3.89	1	Yes	Yes	6	4	2	1
R:R:F201	R:R:L174	10.96	1	Yes	No	5	3	1	2
R:R:A188	R:R:W190	6.48	1	No	Yes	3	6	1	1
R:R:P191	R:R:W190	4.05	1	No	Yes	4	6	2	1
R:R:W190	R:R:W197	9.37	1	Yes	No	6	3	1	2
R:R:G198	R:R:W190	8.44	1	No	Yes	4	6	1	1
R:R:F201	R:R:W190	10.02	1	Yes	Yes	5	6	1	1
R:R:P191	R:R:W197	17.57	1	No	No	4	3	2	2
R:R:F201	R:R:Y204	7.22	1	Yes	No	5	3	1	2
R:R:F201	R:R:T205	7.78	1	Yes	Yes	5	4	1	1
R:R:I202	R:R:L272	8.56	0	No	No	5	4	1	2
R:R:T205	R:R:Y204	9.99	1	Yes	No	4	3	1	2
R:R:F265	R:R:W261	3.01	1	Yes	Yes	7	8	2	2
R:R:S293	R:R:W261	8.65	0	No	Yes	7	8	2	2
R:R:F264	R:R:F265	10.72	1	Yes	Yes	7	7	1	2
R:R:F264	R:R:N268	12.08	1	Yes	No	7	5	1	2
R:R:F264	R:R:S293	3.96	1	Yes	No	7	7	1	2
R:R:L276	R:R:Y286	8.21	0	Yes	No	1	4	2	1
R:R:E279	R:R:Q278	5.1	0	Yes	No	2	1	1	2
R:R:E279	R:R:P280	6.29	0	Yes	No	2	1	1	2
R:R:F201	R:R:P173	2.89	1	Yes	No	5	7	1	2
L:L:F13	R:R:A283	2.77	0	Yes	No	0	4	0	1
L:L:T12	R:R:F287	2.59	0	No	No	0	3	0	1
L:L:R6	R:R:E279	2.33	0	No	Yes	0	2	0	1
R:R:F177	R:R:W190	2	0	No	Yes	4	6	2	1
R:R:A283	R:R:G284	1.95	0	No	No	4	1	1	2
R:R:G184	R:R:T185	1.82	0	No	No	4	4	2	1
L:L:S15	R:R:T185	1.6	0	No	No	0	4	0	1
L:L:C5	R:R:E279	1.52	0	No	Yes	0	2	0	1
R:R:V194	R:R:W190	1.23	0	No	Yes	2	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X8L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	262
Number of Links	304
Number of Hubs	48
Number of Links mediated by Hubs	175
Number of Communities	5
Number of Nodes involved in Communities	58
Number of Links involved in Communities	90

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	69782
Length Of Smallest Path	3
Average Path Length	13.1192
Length of Longest Path	27
Minimum Path Strength	1.37
Average Path Strength	7.04452
Maximum Path Strength	20.855
Minimum Path Correlation	0.7
Average Path Correlation	0.920352
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	45.208
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.3776
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to endogenous stimulus • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • cellular response to chemical stimulus • response to hormone • response to chemical • response to steroid hormone • cellular response to lipid • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • G protein-coupled receptor binding • regulation of cell motility • regulation of locomotion • regulation of cell migration • cell migration • cell motility • locomotion • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35346
Sequence	>8X8L_nogp_Chain_R L V P V L Y L L V C A A G L G G N T L V I Y V V L R F A K M K T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A S F W P F G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H P L S S A R W R R P R V A K L A S A A A W V L S L C M S L P L L V F A D V Q E G G T C N A S W P E P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V L V L V F A G C W L P F F T V N I V N L A V A L P Q E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F R Q S F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZBE	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	Gi1/β1/γ1	3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBE (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-	Gi1/β1/γ1	3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-		3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8X8L	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8L (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-		2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8ZBJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.94	2025-04-30	To be published
	8ZBJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-		2.94	2025-04-30	To be published

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