Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:F6 6.7525460
2L:L:W8 5.862500
3L:L:T10 4.584530
4L:L:F11 6.6975400
5R:R:Y47 4.582507
6R:R:N58 7.0025409
7R:R:V64 3.905407
8R:R:V65 3.315407
9R:R:Y78 3.50333607
10R:R:Y89 7.546516
11R:R:Q99 6.5925434
12R:R:W105 11.972538
13R:R:C112 5.445439
14R:R:V115 4.2175405
15R:R:D119 5.7875416
16R:R:F124 5.0125406
17R:R:F128 3.165425
18R:R:V142 5.5325497
19R:R:R151 5.4675406
20R:R:S167 4.1325407
21R:R:M170 4.588524
22R:R:V180 3.345435
23R:R:W190 13.598556
24R:R:W197 5.5625453
25R:R:F201 7.5775425
26R:R:Y204 4.4523
27R:R:T205 4.505424
28R:R:F210 6.82528
29R:R:Y221 7.768589
30R:R:R240 7.025443
31R:R:E243 8.32167646
32R:R:W261 6.61667628
33R:R:F264 4.6625407
34R:R:F265 4.874527
35R:R:P277 5.22463
36R:R:F287 6.9625403
37R:R:Y294 8.8175417
38R:R:N296 5.94409
39R:R:Y304 4.842579
40R:R:F311 4.035408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F11 R:R:F287 46.06996.43YesYes003
2R:R:F287 R:R:Y47 87.33333.09YesYes037
3R:R:V290 R:R:Y47 90.75275.05NoYes057
4R:R:V290 R:R:Y294 91.64522.52NoYes057
5R:R:D119 R:R:Y294 16.13444.6YesYes167
6L:L:K9 R:R:D119 23.03238.3NoYes006
7L:L:K9 L:L:W8 23.177412.76NoYes000
8L:L:F7 L:L:W8 29.34953.01NoYes000
9L:L:F7 R:R:A188 23.96242.77NoNo003
10L:L:W8 R:R:F201 11.20976.01YesYes005
11L:L:W8 R:R:F264 22.56993.01YesYes007
12L:L:F11 L:L:T10 35.84412.59YesYes000
13L:L:T10 R:R:Q99 58.48395.67YesYes304
14L:L:T10 R:R:N100 34.88714.39YesNo004
15R:R:Y294 R:R:Y89 79.537612.91YesYes176
16R:R:S297 R:R:Y89 55.46777.63NoYes196
17R:R:D86 R:R:S297 46.569910.31NoNo199
18R:R:D86 R:R:N58 46.021510.77NoYes099
19R:R:A83 R:R:N58 13.3281.56NoYes089
20R:R:A83 R:R:I62 11.69891.62NoNo087
21R:R:I62 R:R:T59 10.05911.52NoNo074
22R:R:N58 R:R:P301 31.61299.77YesNo099
23R:R:P301 R:R:V61 30.11293.53NoNo099
24R:R:V61 R:R:V65 28.60211.6NoYes097
25R:R:F311 R:R:V65 19.54842.62YesYes087
26R:R:F311 R:R:V64 13.30656.55YesYes087
27R:R:Q123 R:R:Y89 1005.64NoYes076
28R:R:F124 R:R:Q123 57.53.51YesNo067
29R:R:F124 R:R:S167 51.96772.64YesYes067
30R:R:S167 R:R:T125 46.23666.4YesNo077
31R:R:T125 R:R:W164 41.994620.62NoNo079
32R:R:N81 R:R:W164 37.65595.65NoNo099
33R:R:N81 R:R:S160 33.21511.49NoNo098
34R:R:K157 R:R:S160 31.71516.12NoNo038
35R:R:I77 R:R:K157 30.16672.91NoNo063
36R:R:I77 R:R:Y78 28.65053.63NoYes067
37R:R:V74 R:R:Y78 11.19892.52NoYes067
38R:R:D136 R:R:Y78 11.20975.75NoYes087
39R:R:Q99 R:R:W105 53.650510.95YesYes348
40R:R:L111 R:R:W105 10.90324.56NoYes058
41R:R:F107 R:R:W105 11.069926.06NoYes078
42R:R:C112 R:R:W105 16.27967.84YesYes398
43R:R:C186 R:R:W105 13.58610.45NoYes398
44R:R:C112 R:R:V180 10.96243.42YesYes395
45R:R:P109 R:R:V180 10.94093.53NoYes035
46R:R:C186 R:R:V180 10.87635.12NoYes395
47R:R:Q123 R:R:W261 83.77967.67NoYes078
48R:R:F124 R:R:M170 12.23128.71YesYes064
49R:R:F124 R:R:T205 14.59685.19YesYes064
50R:R:V127 R:R:W261 43.69893.68NoYes088
51R:R:P213 R:R:V127 38.45163.53NoNo088
52R:R:F210 R:R:W261 13.60759.02YesYes288
53R:R:N296 R:R:W261 52.31727.91YesYes098
54R:R:N296 R:R:N300 44.63988.17YesNo099
55R:R:N300 R:R:Y304 42.05383.49NoYes799
56R:R:P213 R:R:T131 35.96776.99NoNo087
57R:R:I217 R:R:T131 33.51614.56NoNo087
58R:R:I217 R:R:S134 32.30644.64NoNo089
59R:R:C220 R:R:S134 30.60755.16NoNo889
60R:R:V253 R:R:Y304 40.349510.09NoYes089
61R:R:V253 R:R:Y221 34.1725.05NoYes089
62R:R:C220 R:R:Y221 30.4144.03NoYes889
63R:R:C220 R:R:Y138 58.31724.03NoNo088
64R:R:V142 R:R:Y138 53.07538.83YesNo078
65R:R:R151 R:R:S147 13.24195.27YesNo065
66R:R:K227 R:R:V142 36.4574.55NoYes957
67R:R:A188 R:R:W197 20.56453.89NoYes033
68R:R:W190 R:R:W197 13.279613.12YesYes563
69R:R:F265 R:R:W261 17.18824.01YesYes278
70R:R:F257 R:R:L214 13.3283.65NoNo097
71R:R:K227 R:R:V228 33.94623.04NoNo058
72R:R:E243 R:R:V228 28.65059.98YesNo068
73R:R:E243 R:R:R240 14.43014.65YesYes463
74R:R:S293 R:R:W261 12.8717.41NoYes078
75R:R:F264 R:R:V289 12.19893.93YesNo077
76R:R:F287 R:R:N100 35.897815.71YesNo034
77R:R:F264 R:R:F265 15.27966.43YesYes077
78R:R:F264 R:R:S293 11.70975.28YesNo077
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F6 R:R:N271 3.62 6 Yes No 0 4 0 1
L:L:F6 R:R:P277 7.22 6 Yes Yes 0 3 0 1
L:L:F7 R:R:A188 2.77 0 No No 0 3 0 1
L:L:W8 R:R:F201 6.01 0 Yes Yes 0 5 0 1
L:L:W8 R:R:F264 3.01 0 Yes Yes 0 7 0 1
L:L:W8 R:R:N268 4.52 0 Yes No 0 5 0 1
L:L:K9 R:R:D119 8.3 0 No Yes 0 6 0 1
L:L:T10 R:R:L96 4.42 3 Yes No 0 6 0 1
L:L:T10 R:R:Q99 5.67 3 Yes Yes 0 4 0 1
L:L:T10 R:R:N100 4.39 3 Yes No 0 4 0 1
L:L:T10 R:R:N187 5.85 3 Yes No 0 5 0 1
L:L:F11 R:R:A283 2.77 0 Yes No 0 4 0 1
L:L:F11 R:R:F287 6.43 0 Yes Yes 0 3 0 1
L:L:T12 R:R:N187 8.77 0 No No 0 5 0 1
R:R:F287 R:R:V43 2.62 0 Yes No 3 6 1 2
R:R:F287 R:R:Y47 3.09 0 Yes Yes 3 7 1 2
R:R:D119 R:R:Y89 6.9 1 Yes Yes 6 6 1 2
R:R:Y294 R:R:Y89 12.91 1 Yes Yes 7 6 2 2
R:R:L96 R:R:Q99 2.66 3 No Yes 6 4 1 1
R:R:Q99 R:R:W105 10.95 3 Yes Yes 4 8 1 2
R:R:Q99 R:R:T185 7.09 3 Yes No 4 4 1 2
R:R:F287 R:R:N100 15.71 0 Yes No 3 4 1 1
R:R:D119 R:R:G120 3.35 1 Yes No 6 5 1 2
R:R:D119 R:R:Y294 4.6 1 Yes Yes 6 7 1 2
R:R:F201 R:R:L174 8.53 2 Yes No 5 3 1 2
R:R:A188 R:R:W197 3.89 0 No Yes 3 3 1 2
R:R:F201 R:R:Y204 9.28 2 Yes Yes 5 3 1 2
R:R:F201 R:R:T205 6.49 2 Yes Yes 5 4 1 2
R:R:I202 R:R:N268 12.74 0 No No 5 5 2 1
R:R:T205 R:R:Y204 3.75 2 Yes Yes 4 3 2 2
R:R:F265 R:R:T205 2.59 2 Yes Yes 7 4 2 2
R:R:F264 R:R:F265 6.43 0 Yes Yes 7 7 1 2
R:R:F264 R:R:V289 3.93 0 Yes No 7 7 1 2
R:R:F264 R:R:S293 5.28 0 Yes No 7 7 1 2
R:R:N271 R:R:P277 4.89 6 No Yes 4 3 1 1
R:R:P277 R:R:S282 7.13 6 Yes No 3 5 1 2
R:R:A283 R:R:G284 1.95 0 No No 4 1 1 2
R:R:A178 R:R:A188 1.79 0 No No 5 3 2 1
R:R:G198 R:R:L272 1.71 0 No No 4 4 1 2
R:R:L276 R:R:P277 1.64 0 No Yes 1 3 2 1
L:L:F7 R:R:G198 1.51 0 No No 0 4 0 1
L:L:F6 R:R:Q278 1.17 6 Yes No 0 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8ZBJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.52
Number of Linked Nodes 244
Number of Links 268
Number of Hubs 40
Number of Links mediated by Hubs 145
Number of Communities 9
Number of Nodes involved in Communities 48
Number of Links involved in Communities 57
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 44124
Length Of Smallest Path 3
Average Path Length 14.3327
Length of Longest Path 30
Minimum Path Strength 1.375
Average Path Strength 5.9723
Maximum Path Strength 23.46
Minimum Path Correlation 0.7
Average Path Correlation 0.919977
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 42.6701
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.6741
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• response to acid chemical   • response to stimulus   • response to chemical   • response to amino acid   • response to xenobiotic stimulus   • regulation of postsynaptic membrane neurotransmitter receptor levels   • biological regulation   • regulation of biological quality   • somatostatin signaling pathway   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • response to endogenous stimulus   • hormone-mediated signaling pathway   • cell communication   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • somatostatin receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cellular response to hormone stimulus   • cell-cell signaling   • regulation of cell motility   • regulation of locomotion   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • response to osmotic stress   • hyperosmotic response   • response to stress   • response to abiotic stimulus   • cell surface receptor signaling pathway   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • response to lipid   • response to steroid hormone   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cell death   • apoptotic signaling pathway   • hormone-mediated apoptotic signaling pathway   • apoptotic process   • programmed cell death   • response to nutrient levels   • response to nutrient   • response to pH   • response to acidic pH   • multicellular organismal process   • digestion   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cellular anatomical structure   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cellular anatomical structure   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • cytosol   • GABA-ergic synapse   • synapse   • cell junction   • extracellular region   • somatodendritic compartment   • cell body   • neuronal cell body   • extracellular space   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • somatostatin receptor activity   • neuropeptide receptor activity   • neuropeptide binding   • peptide binding   • neuropeptide signaling pathway   • regulation of cytokinesis   • positive regulation of cell division   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • response to glucocorticoid   • cellular response to glucocorticoid stimulus   • cellular response to corticosteroid stimulus   • cellular response to endogenous stimulus   • response to corticosteroid   • response to steroid hormone   • cellular response to steroid hormone stimulus   • cellular response to hormone stimulus   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • neuron projection   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35346
Sequence
>8ZBJ_nogp_Chain_R
AVLVPVLYL LVCAAGLGG NTLVIYVVL RFATVTNIY ILNLAVADV 
LYMLGLPFL ATQNAASFW PFGPVLCRL VMTLDGVNQ FTSVFCLTV 
MSVDRYLAV VHPLSSARW RRPRVAKLA SAAAWVLSL CMSLPLLVF 
ADVQEGGTC NASWPEPVG LWGAVFIIY TAVLGFFAP LLVICLCYL 
LIVVKVRRR SERKVTRMV LVVVLVFAG CWLPFFTVN IVNLAVALP 
QEPASAGLY FFVVILSYA NSCANPVLY GFLSDNFRQ SFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZBEAPeptideSomatostatinSST5Homo sapiensOctreotide-Gi1/β1/γ13.242024-07-10doi.org/10.1038/s41401-024-01314-8
8ZBE (No Gprot) APeptideSomatostatinSST5Homo sapiensOctreotide-3.242024-07-10doi.org/10.1038/s41401-024-01314-8
8ZCJAPeptideSomatostatinSST5Homo sapiensPasireotide-Gi1/β1/γ13.092024-07-10doi.org/10.1038/s41401-024-01314-8
8ZCJ (No Gprot) APeptideSomatostatinSST5Homo sapiensPasireotide-3.092024-07-10doi.org/10.1038/s41401-024-01314-8
8X8LAPeptideSomatostatinSST5Homo sapiensCortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ22.72024-06-12doi.org/10.1073/pnas.2321710121
8X8L (No Gprot) APeptideSomatostatinSST5Homo sapiensCortistatin-2.72024-06-12doi.org/10.1073/pnas.2321710121
8X8NAPeptideSomatostatinSST5Homo sapiensOctreotide-chim(NtGi1-Gs-CtGi1)/β1/γ22.92024-06-12doi.org/10.1073/pnas.2321710121
8X8N (No Gprot) APeptideSomatostatinSST5Homo sapiensOctreotide-2.92024-06-12doi.org/10.1073/pnas.2321710121
8ZBJAPeptideSomatostatinSST5Homo sapiensSomatostatin-14-Gi1/β1/γ22.942025-04-30To be published
8ZBJ (No Gprot) APeptideSomatostatinSST5Homo sapiensSomatostatin-14-2.942025-04-30To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZBJ_nogp.zip



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