psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	18.65	Yes	Yes	1	0	0
2	L:L:?1	L:L:?6	21.48	Yes	No	1	0	0
3	L:L:?1	R:R:I202	4.62	Yes	Yes	1	0	5
4	L:L:?1	R:R:N268	7.77	Yes	Yes	1	0	5
5	L:L:?1	R:R:N271	6.66	Yes	No	1	0	4
6	L:L:?2	L:L:K3	12.31	Yes	Yes	1	0	0
7	L:L:?2	R:R:Q123	8.45	Yes	Yes	1	0	7
8	L:L:?2	R:R:F124	3.87	Yes	Yes	1	0	6
9	L:L:?2	R:R:F201	3.87	Yes	Yes	0	0	5
10	L:L:?2	R:R:F264	4.83	Yes	Yes	1	0	7
11	L:L:?2	R:R:N268	8.72	Yes	Yes	1	0	5
12	L:L:K3	R:R:Y89	5.97	Yes	Yes	1	0	6
13	L:L:K3	R:R:D119	13.83	Yes	No	1	0	6
14	L:L:K3	R:R:F264	8.69	Yes	Yes	1	0	7
15	L:L:?5	L:L:Y4	3.69	Yes	No	1	0	0
16	L:L:Y4	R:R:Q99	10.15	No	No	1	0	4
17	L:L:Y4	R:R:T185	16.23	No	Yes	1	0	4
18	L:L:?5	L:L:?6	31.86	Yes	No	1	0	0
19	L:L:?5	R:R:L276	5.45	Yes	Yes	1	0	1
20	L:L:?5	R:R:S282	5.91	Yes	No	1	0	5
21	L:L:?5	R:R:Y286	13.84	Yes	No	1	0	4
22	L:L:?6	R:R:N271	8.79	No	No	1	0	4
23	R:R:P44	R:R:V43	5.3	No	No	0	5	6
24	R:R:F288	R:R:V43	5.24	No	No	0	4	6
25	R:R:L49	R:R:V45	4.47	No	No	0	5	5
26	R:R:L93	R:R:Y47	19.93	No	No	0	7	7
27	R:R:V290	R:R:Y47	7.57	No	No	0	5	7
28	R:R:I291	R:R:Y47	20.55	No	No	0	5	7
29	R:R:C51	R:R:L48	3.17	Yes	No	0	6	4
30	R:R:C51	R:R:L93	3.17	Yes	No	0	6	7
31	R:R:C51	R:R:P94	7.53	Yes	No	0	6	8
32	R:R:G54	R:R:Y294	4.35	No	Yes	0	8	7
33	R:R:G56	R:R:L55	3.42	No	Yes	2	4	6
34	R:R:L55	R:R:T59	4.42	Yes	No	2	6	4
35	R:R:L55	R:R:V87	5.96	Yes	No	0	6	7
36	R:R:L55	R:R:M90	11.31	Yes	No	0	6	6
37	R:R:G56	R:R:T59	3.64	No	No	2	4	4
38	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
39	R:R:N58	R:R:V87	5.91	No	No	0	9	7
40	R:R:N58	R:R:P301	16.29	No	No	0	9	9
41	R:R:F306	R:R:L60	7.31	No	No	0	7	6
42	R:R:A83	R:R:V61	3.39	No	No	0	8	9
43	R:R:P301	R:R:V61	3.53	No	No	0	9	9
44	R:R:I62	R:R:L80	5.71	No	Yes	3	7	6
45	R:R:A83	R:R:I62	3.25	No	No	0	8	7
46	R:R:I62	R:R:V84	4.61	No	No	3	7	6
47	R:R:R67	R:R:Y63	22.64	No	No	0	4	4
48	R:R:F311	R:R:V64	11.8	Yes	No	0	8	7
49	R:R:S314	R:R:V64	3.23	Yes	No	0	5	7
50	R:R:N76	R:R:V65	14.78	No	Yes	0	8	7
51	R:R:I79	R:R:V65	4.61	No	Yes	0	8	7
52	R:R:L80	R:R:V65	4.47	Yes	Yes	0	6	7
53	R:R:F311	R:R:V65	9.18	Yes	Yes	0	8	7
54	R:R:L66	R:R:L80	6.92	No	Yes	0	3	6
55	R:R:F311	R:R:K70	9.93	Yes	No	0	8	5
56	R:R:K70	R:R:S314	10.71	No	Yes	0	5	5
57	R:R:K72	R:R:M71	5.76	No	No	0	6	7
58	R:R:K72	R:R:P153	6.69	No	No	0	6	2
59	R:R:D136	R:R:V74	5.84	No	No	4	8	6
60	R:R:R151	R:R:V74	10.46	Yes	No	4	6	6
61	R:R:A156	R:R:V74	3.39	No	No	0	7	6
62	R:R:A156	R:R:I77	4.87	No	No	0	7	6
63	R:R:V132	R:R:Y78	7.57	No	No	0	7	7
64	R:R:D136	R:R:Y78	8.05	No	No	0	8	7
65	R:R:A159	R:R:Y78	4	No	No	0	5	7
66	R:R:L80	R:R:V84	4.47	Yes	No	3	6	6
67	R:R:C129	R:R:N81	7.87	No	No	0	8	9
68	R:R:N81	R:R:S160	10.43	No	No	0	9	8
69	R:R:N81	R:R:W164	7.91	No	No	0	9	9
70	R:R:D86	R:R:L82	4.07	Yes	No	1	9	9
71	R:R:C129	R:R:L82	9.52	No	No	0	8	9
72	R:R:L82	R:R:N300	6.87	No	Yes	1	9	9
73	R:R:V84	R:R:W164	4.9	No	No	0	6	9
74	R:R:D86	R:R:S126	7.36	Yes	No	0	9	9
75	R:R:D86	R:R:N296	4.04	Yes	Yes	1	9	9
76	R:R:D86	R:R:S297	11.78	Yes	No	1	9	9
77	R:R:D86	R:R:N300	5.39	Yes	Yes	1	9	9
78	R:R:L88	R:R:L91	4.15	No	No	0	7	4
79	R:R:L88	R:R:N122	9.61	No	Yes	0	7	8
80	R:R:D119	R:R:Y89	8.05	No	Yes	1	6	6
81	R:R:N122	R:R:Y89	5.81	Yes	Yes	0	8	6
82	R:R:Q123	R:R:Y89	6.76	Yes	Yes	1	7	6
83	R:R:S297	R:R:Y89	6.36	No	Yes	1	9	6
84	R:R:L91	R:R:M90	5.65	No	No	0	4	6
85	R:R:M90	R:R:Y294	7.18	No	Yes	0	6	7
86	R:R:L93	R:R:Y294	14.07	No	Yes	0	7	7
87	R:R:F95	R:R:V115	5.24	No	No	0	6	5
88	R:R:T98	R:R:W105	4.85	No	Yes	0	4	8
89	R:R:F104	R:R:Q99	9.37	Yes	No	1	4	4
90	R:R:Q99	R:R:T185	4.25	No	Yes	1	4	4
91	R:R:N100	R:R:W105	7.91	No	Yes	0	4	8
92	R:R:F104	R:R:T185	5.19	Yes	Yes	1	4	4
93	R:R:P106	R:R:W105	4.05	No	Yes	0	3	8
94	R:R:P106	R:R:V110	10.6	No	No	0	3	2
95	R:R:G108	R:R:P109	4.06	No	No	0	8	3
96	R:R:G108	R:R:L111	5.13	No	No	0	8	5
97	R:R:V110	R:R:V115	3.21	No	No	0	2	5
98	R:R:C112	R:R:V180	5.12	Yes	No	0	9	5
99	R:R:C112	R:R:C186	7.28	Yes	No	5	9	9
100	R:R:C186	R:R:M116	8.1	No	No	0	9	5
101	R:R:S171	R:R:T117	6.4	No	No	0	7	6
102	R:R:L175	R:R:T117	10.32	No	No	0	5	6
103	R:R:D119	R:R:G120	5.03	No	No	0	6	5
104	R:R:N122	R:R:V121	4.43	Yes	Yes	0	8	5
105	R:R:S167	R:R:V121	9.7	No	Yes	0	7	5
106	R:R:S171	R:R:V121	6.46	No	Yes	0	7	5
107	R:R:F124	R:R:Q123	8.2	Yes	Yes	1	6	7
108	R:R:Q123	R:R:W261	8.76	Yes	Yes	0	7	8
109	R:R:F265	R:R:Q123	5.86	No	Yes	0	7	7
110	R:R:F124	R:R:M170	7.46	Yes	No	0	6	4
111	R:R:F124	R:R:T205	3.89	Yes	No	0	6	4
112	R:R:T125	R:R:W164	6.06	Yes	No	0	7	9
113	R:R:S167	R:R:T125	7.99	No	Yes	0	7	7
114	R:R:P213	R:R:V127	5.3	Yes	No	0	8	8
115	R:R:F257	R:R:V127	5.24	Yes	No	0	9	8
116	R:R:V127	R:R:W261	4.9	No	Yes	0	8	8
117	R:R:F128	R:R:L166	3.65	No	No	0	5	4
118	R:R:F128	R:R:L208	6.09	No	No	0	5	4
119	R:R:C129	R:R:V132	3.42	No	No	0	8	7
120	R:R:F257	R:R:L130	9.74	Yes	No	0	9	9
121	R:R:L130	R:R:Y304	9.38	No	Yes	0	9	9
122	R:R:P213	R:R:T131	3.5	Yes	No	0	8	7
123	R:R:I217	R:R:T131	12.16	No	No	0	8	7
124	R:R:M133	R:R:R137	6.2	No	Yes	1	8	9
125	R:R:M133	R:R:Y304	8.38	No	Yes	1	8	9
126	R:R:I217	R:R:S134	7.74	No	No	0	8	9
127	R:R:C220	R:R:S134	3.44	No	No	0	8	9
128	R:R:S134	R:R:Y221	6.36	No	Yes	0	9	9
129	R:R:L139	R:R:V135	4.47	No	No	0	5	6
130	R:R:D136	R:R:R151	10.72	No	Yes	4	8	6
131	R:R:R137	R:R:Y221	11.32	Yes	Yes	1	9	9
132	R:R:R137	R:R:Y304	4.12	Yes	Yes	1	9	9
133	R:R:V142	R:R:Y138	15.14	No	No	6	7	8
134	R:R:H143	R:R:Y138	9.8	No	No	6	7	8
135	R:R:C220	R:R:Y138	4.03	No	No	0	8	8
136	R:R:A140	R:R:R151	4.15	No	Yes	0	8	6
137	R:R:I224	R:R:V141	4.61	No	No	0	8	8
138	R:R:H143	R:R:V142	9.69	No	No	6	7	7
139	R:R:K227	R:R:V142	7.59	No	No	0	5	7
140	R:R:L145	R:R:P144	3.28	No	No	0	5	7
141	R:R:R151	R:R:S147	9.22	Yes	No	0	6	5
142	R:R:R149	R:R:W150	5	No	No	0	3	4
143	R:R:R152	R:R:V155	5.23	No	No	0	6	4
144	R:R:C169	R:R:L166	4.76	No	No	0	3	4
145	R:R:L174	R:R:S171	4.5	No	No	0	3	7
146	R:R:F201	R:R:L174	7.31	Yes	No	0	5	3
147	R:R:F177	R:R:W190	40.09	No	No	0	4	6
148	R:R:D179	R:R:Q181	6.53	No	No	0	4	1
149	R:R:D179	R:R:P191	8.05	No	No	0	4	4
150	R:R:N187	R:R:Q181	9.24	No	No	0	5	1
151	R:R:N187	R:R:S189	4.47	No	No	0	5	1
152	R:R:S189	R:R:V194	4.85	No	No	0	1	2
153	R:R:G198	R:R:S189	3.71	No	No	0	4	1
154	R:R:P191	R:R:W190	4.05	No	No	0	4	6
155	R:R:W190	R:R:W197	17.81	No	No	0	6	3
156	R:R:E192	R:R:P193	9.43	No	No	0	3	4
157	R:R:P193	R:R:W197	5.4	No	No	0	4	3
158	R:R:A199	R:R:L272	4.73	No	No	0	3	4
159	R:R:V200	R:R:Y204	6.31	No	No	0	4	3
160	R:R:F201	R:R:I202	3.77	Yes	Yes	0	5	5
161	R:R:F201	R:R:T205	7.78	Yes	No	0	5	4
162	R:R:I202	R:R:N268	4.25	Yes	Yes	1	5	5
163	R:R:I203	R:R:Y204	3.63	No	No	0	5	3
164	R:R:F211	R:R:V207	10.49	No	No	0	5	5
165	R:R:F210	R:R:W261	8.02	No	Yes	0	8	8
166	R:R:F210	R:R:L262	7.31	No	No	0	8	5
167	R:R:F210	R:R:F265	6.43	No	No	0	8	7
168	R:R:C218	R:R:L214	6.35	No	No	0	4	7
169	R:R:F257	R:R:L214	3.65	Yes	No	0	9	7
170	R:R:C218	R:R:V254	5.12	No	No	0	4	7
171	R:R:V250	R:R:Y221	10.09	No	Yes	0	7	9
172	R:R:Y221	R:R:Y304	10.92	Yes	Yes	1	9	9
173	R:R:S242	R:R:V228	3.23	No	No	0	5	8
174	R:R:E243	R:R:V228	4.28	No	No	0	6	8
175	R:R:E243	R:R:R229	4.65	No	No	0	6	4
176	R:R:R234	R:R:V235	5.23	No	No	0	2	4
177	R:R:G236	R:R:V235	3.68	No	No	0	3	4
178	R:R:R239	R:R:R241	9.6	No	No	0	3	4
179	R:R:E243	R:R:R240	16.28	No	No	0	6	3
180	R:R:L307	R:R:M249	5.65	No	No	0	6	8
181	R:R:M249	R:R:S308	4.6	No	No	0	8	8
182	R:R:L303	R:R:V253	5.96	Yes	No	0	8	8
183	R:R:F257	R:R:N296	9.67	Yes	Yes	0	9	9
184	R:R:C260	R:R:L292	4.76	No	No	0	8	7
185	R:R:A295	R:R:C260	3.61	No	No	0	5	8
186	R:R:S293	R:R:W261	3.71	No	Yes	0	7	8
187	R:R:L262	R:R:P263	3.28	No	No	0	5	9
188	R:R:L262	R:R:T266	7.37	No	No	0	5	6
189	R:R:L292	R:R:P263	3.28	No	No	0	7	9
190	R:R:F264	R:R:F265	5.36	Yes	No	0	7	7
191	R:R:F264	R:R:S293	3.96	Yes	No	0	7	7
192	R:R:N268	R:R:V267	4.43	Yes	No	1	5	5
193	R:R:V267	R:R:Y286	11.36	No	No	1	5	4
194	R:R:N268	R:R:Y286	4.65	Yes	No	1	5	4
195	R:R:L276	R:R:N271	6.87	Yes	No	1	1	4
196	R:R:L276	R:R:S282	7.51	Yes	No	1	1	5
197	R:R:E279	R:R:P277	9.43	No	No	0	2	3
198	R:R:A283	R:R:F287	4.16	No	No	0	4	3
199	R:R:F287	R:R:G284	6.02	No	No	0	3	1
200	R:R:F288	R:R:I291	3.77	No	No	0	4	5
201	R:R:C298	R:R:Y294	5.38	No	Yes	0	8	7
202	R:R:N296	R:R:S297	5.96	Yes	No	1	9	9
203	R:R:N296	R:R:N300	9.54	Yes	Yes	1	9	9
204	R:R:N300	R:R:Y304	8.14	Yes	Yes	1	9	9
205	R:R:F306	R:R:F311	6.43	No	Yes	0	7	8
206	R:R:F306	R:R:F315	13.93	No	No	0	7	6
207	R:R:F315	R:R:R312	11.76	No	No	0	6	8
208	R:R:F315	R:R:Q316	15.23	No	No	0	6	4
209	R:R:A101	R:R:N100	3.13	No	No	0	4	4
210	R:R:I79	R:R:T75	3.04	No	No	0	8	7
211	R:R:M116	R:R:T185	3.01	No	Yes	0	5	4
212	R:R:L46	R:R:V50	2.98	No	No	0	5	7
213	R:R:L168	R:R:V121	2.98	No	Yes	0	4	5
214	R:R:L172	R:R:V176	2.98	No	No	0	5	4
215	R:R:L196	R:R:V200	2.98	No	No	0	1	4
216	R:R:L208	R:R:V207	2.98	No	No	0	4	5
217	R:R:L219	R:R:V254	2.98	No	No	0	4	7
218	R:R:L285	R:R:V289	2.98	No	No	0	5	7
219	R:R:L251	R:R:T247	2.95	No	No	0	4	6
220	R:R:Q313	R:R:S314	2.89	No	Yes	0	4	5
221	R:R:L208	R:R:M170	2.83	No	No	0	4	4
222	R:R:L251	R:R:L255	2.77	No	No	0	4	4
223	R:R:L118	R:R:N122	2.75	No	Yes	0	5	8
224	R:R:F68	R:R:S314	2.64	No	Yes	0	5	5
225	R:R:R229	R:R:V226	2.62	No	No	0	4	3
226	R:R:F264	R:R:V289	2.62	Yes	No	0	7	7
227	R:R:V50	R:R:Y294	2.52	No	Yes	0	7	7
228	R:R:I224	R:R:R137	2.51	No	Yes	0	8	9
229	L:L:?5	R:R:A283	2.48	Yes	No	0	0	4
230	R:R:M249	R:R:R248	2.48	No	No	0	8	5
231	R:R:F104	R:R:L96	2.44	Yes	No	0	4	6
232	R:R:L139	R:R:R151	2.43	No	Yes	0	5	6
233	R:R:M170	R:R:Y204	2.39	No	No	0	4	3
234	L:L:?1	R:R:L272	2.24	Yes	No	0	0	4
235	R:R:G56	R:R:G57	2.11	No	No	0	4	8
236	R:R:G183	R:R:G184	2.11	No	No	0	1	4
237	L:L:?5	R:R:Q278	2.09	Yes	No	0	0	1
238	R:R:G92	R:R:P94	2.03	No	No	0	6	8
239	R:R:G209	R:R:P213	2.03	No	Yes	0	5	8
240	R:R:F104	R:R:W105	2	Yes	Yes	0	4	8
241	R:R:A53	R:R:G54	1.95	No	No	0	5	8
242	R:R:A102	R:R:G184	1.95	No	No	0	3	4
243	R:R:A231	R:R:G232	1.95	No	No	0	5	4
244	R:R:A258	R:R:G259	1.95	No	No	0	5	5
245	R:R:A212	R:R:P213	1.87	No	Yes	0	5	8
246	R:R:A52	R:R:C51	1.81	No	Yes	0	5	6
247	R:R:A178	R:R:C112	1.81	No	Yes	0	5	9
248	R:R:A178	R:R:A188	1.79	No	No	0	5	3
249	R:R:P144	R:R:S147	1.78	No	No	0	7	5
250	R:R:G305	R:R:I79	1.76	No	No	0	7	8
251	R:R:A85	R:R:T125	1.68	No	Yes	0	8	7
252	R:R:A163	R:R:T125	1.68	No	Yes	0	6	7
253	R:R:L172	R:R:P173	1.64	No	No	0	5	7
254	R:R:L276	R:R:P277	1.64	Yes	No	0	1	3
255	R:R:V225	R:R:V226	1.6	Yes	No	0	5	3
256	R:R:V225	R:R:V246	1.6	Yes	No	7	5	7
257	R:R:C112	R:R:L111	1.59	Yes	No	5	9	5
258	R:R:C186	R:R:L111	1.59	No	No	5	9	5
259	R:R:T247	R:R:V225	1.59	No	Yes	7	6	5
260	R:R:T247	R:R:V246	1.59	No	No	7	6	7
261	R:R:A258	R:R:L214	1.58	No	No	0	5	7
262	R:R:E279	R:R:P280	1.57	No	No	0	2	1
263	R:R:I217	R:R:V216	1.54	No	No	0	8	7
264	R:R:F201	R:R:G198	1.51	Yes	No	0	5	4
265	R:R:A281	R:R:E279	1.51	No	No	0	1	2
266	R:R:L222	R:R:V225	1.49	No	Yes	0	3	5
267	R:R:L222	R:R:V250	1.49	No	No	0	3	7
268	R:R:L222	R:R:V254	1.49	No	No	0	3	7
269	R:R:L303	R:R:V252	1.49	Yes	No	0	8	6
270	R:R:L303	R:R:V256	1.49	Yes	No	0	8	6
271	R:R:I202	R:R:I269	1.47	Yes	No	0	5	6
272	R:R:I203	R:R:I269	1.47	No	No	0	5	6
273	R:R:N76	R:R:T73	1.46	No	No	0	8	7
274	R:R:I77	R:R:K157	1.45	No	No	0	6	3
275	R:R:P153	R:R:R152	1.44	No	No	0	2	6
276	R:R:M71	R:R:N76	1.4	No	No	0	7	8
277	R:R:H143	R:R:S146	1.39	No	No	0	7	4
278	R:R:L48	R:R:L49	1.38	No	No	0	4	5
279	R:R:L114	R:R:L118	1.38	No	No	0	5	5
280	R:R:L215	R:R:L219	1.38	No	No	0	3	4
281	R:R:L303	R:R:L307	1.38	Yes	No	0	8	6
282	R:R:V253	R:R:Y304	1.26	No	Yes	0	8	9
283	R:R:F68	R:R:K317	1.24	No	No	0	5	4
284	R:R:K245	R:R:R244	1.24	No	No	0	7	4
285	R:R:K245	R:R:R248	1.24	No	No	0	7	5
286	R:R:D309	R:R:R312	1.19	No	No	0	5	8
287	R:R:R149	R:R:R152	1.07	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.2367	6	1	0
2	L:L:?2	8.67143	7	1	0
3	L:L:K3	10.2	4	1	0
4	L:L:?5	9.33143	7	1	0
5	R:R:C51	3.92	4	0	6
6	R:R:L55	6.2775	4	2	6
7	R:R:V65	8.26	4	0	7
8	R:R:L80	5.3925	4	3	6
9	R:R:D86	6.56167	6	1	9
10	R:R:Y89	6.59	5	1	6
11	R:R:F104	4.75	4	1	4
12	R:R:W105	4.7025	4	0	8
13	R:R:C112	3.95	4	5	9
14	R:R:V121	5.8925	4	0	5
15	R:R:N122	5.65	4	0	8
16	R:R:Q123	7.606	5	1	7
17	R:R:F124	5.855	4	1	6
18	R:R:T125	4.3525	4	0	7
19	R:R:R137	6.0375	4	1	9
20	R:R:R151	7.396	5	4	6
21	R:R:T185	7.17	4	1	4
22	R:R:F201	4.848	5	0	5
23	R:R:I202	3.5275	4	1	5
24	R:R:P213	3.175	4	0	8
25	R:R:Y221	9.6725	4	1	9
26	R:R:V225	1.57	4	7	5
27	R:R:F257	7.075	4	0	9
28	R:R:W261	6.3475	4	0	8
29	R:R:F264	5.092	5	1	7
30	R:R:N268	5.964	5	1	5
31	R:R:L276	5.3675	4	1	1
32	R:R:Y294	6.7	5	0	7
33	R:R:N296	7.3025	4	1	9
34	R:R:N300	7.485	4	1	9
35	R:R:L303	2.58	4	0	8
36	R:R:Y304	7.03333	6	1	9
37	R:R:F311	9.335	4	0	8
38	R:R:S314	4.8675	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	67.354	18.65	Yes	Yes	1	0	0
2	L:L:?2	L:L:K3	46.1266	12.31	Yes	Yes	1	0	0
3	L:L:?2	R:R:Q123	68.4405	8.45	Yes	Yes	1	0	7
4	L:L:?2	R:R:F201	30.5931	3.87	Yes	Yes	0	0	5
5	L:L:?1	R:R:I202	11.5109	4.62	Yes	Yes	1	0	5
6	R:R:F201	R:R:I202	18.956	3.77	Yes	Yes	0	5	5
7	L:L:K3	R:R:Y89	47.1084	5.97	Yes	Yes	1	0	6
8	R:R:Q123	R:R:Y89	57.2928	6.76	Yes	Yes	1	7	6
9	L:L:?1	L:L:?6	60.2228	21.48	Yes	No	1	0	0
10	L:L:?5	L:L:?6	58.9148	31.86	Yes	No	1	0	0
11	L:L:?5	L:L:Y4	100	3.69	Yes	No	1	0	0
12	L:L:Y4	R:R:Q99	34.5049	10.15	No	No	1	0	4
13	L:L:Y4	R:R:T185	62.4234	16.23	No	Yes	1	0	4
14	L:L:?1	R:R:N271	10.923	6.66	Yes	No	1	0	4
15	R:R:N268	R:R:Y286	59.8904	4.65	Yes	No	1	5	4
16	R:R:N122	R:R:Y89	56.1017	5.81	Yes	Yes	0	8	6
17	R:R:L88	R:R:N122	25.3947	9.61	No	Yes	0	7	8
18	R:R:L88	R:R:L91	24.099	4.15	No	No	0	7	4
19	R:R:L91	R:R:M90	22.9879	5.65	No	No	0	4	6
20	R:R:M90	R:R:Y294	25.7271	7.18	No	Yes	0	6	7
21	R:R:L93	R:R:Y294	18.2666	14.07	No	Yes	0	7	7
22	R:R:L55	R:R:M90	11.5478	11.31	Yes	No	0	6	6
23	R:R:S297	R:R:Y89	57.1143	6.36	No	Yes	1	9	6
24	R:R:D86	R:R:S297	40.1126	11.78	Yes	No	1	9	9
25	R:R:D86	R:R:N58	17.3987	6.73	Yes	No	0	9	9
26	R:R:N58	R:R:V87	13.5853	5.91	No	No	0	9	7
27	R:R:L55	R:R:V87	12.4711	5.96	Yes	No	0	6	7
28	R:R:N122	R:R:V121	33.0307	4.43	Yes	Yes	0	8	5
29	R:R:S167	R:R:V121	52.553	9.7	No	Yes	0	7	5
30	R:R:S167	R:R:T125	51.1188	7.99	No	Yes	0	7	7
31	R:R:T125	R:R:W164	47.9148	6.06	Yes	No	0	7	9
32	R:R:V84	R:R:W164	54.966	4.9	No	No	0	6	9
33	R:R:L80	R:R:V84	51.6605	4.47	Yes	No	3	6	6
34	R:R:L80	R:R:V65	53.027	4.47	Yes	Yes	0	6	7
35	R:R:F311	R:R:V65	30.7439	9.18	Yes	Yes	0	8	7
36	R:R:F306	R:R:F311	11.1138	6.43	No	Yes	0	7	8
37	R:R:F201	R:R:L174	29.8637	7.31	Yes	No	0	5	3
38	R:R:L174	R:R:S171	29.2173	4.5	No	No	0	3	7
39	R:R:S171	R:R:V121	28.8757	6.46	No	Yes	0	7	5
40	R:R:N76	R:R:V65	16.4169	14.78	No	Yes	0	8	7
41	R:R:M71	R:R:N76	12.7728	1.4	No	No	0	7	8
42	R:R:K72	R:R:M71	10.9415	5.76	No	No	0	6	7
43	R:R:D86	R:R:L82	20.378	4.07	Yes	No	1	9	9
44	R:R:C129	R:R:L82	29.996	9.52	No	No	0	8	9
45	R:R:C129	R:R:V132	20.1717	3.42	No	No	0	8	7
46	R:R:V132	R:R:Y78	18.8698	7.57	No	No	0	7	7
47	R:R:D136	R:R:Y78	16.2445	8.05	No	No	0	8	7
48	R:R:C129	R:R:N81	13.2529	7.87	No	No	0	8	9
49	R:R:D86	R:R:N300	19.033	5.39	Yes	Yes	1	9	9
50	R:R:N296	R:R:S297	16.777	5.96	Yes	No	1	9	9
51	R:R:N296	R:R:N300	17.9465	9.54	Yes	Yes	1	9	9
52	R:R:F104	R:R:Q99	31.6365	9.37	Yes	No	1	4	4
53	R:R:F104	R:R:W105	50.891	2	Yes	Yes	0	4	8
54	R:R:P106	R:R:W105	25.4932	4.05	No	Yes	0	3	8
55	R:R:P106	R:R:V110	19.1284	10.6	No	No	0	3	2
56	R:R:V110	R:R:V115	12.7574	3.21	No	No	0	2	5
57	R:R:F104	R:R:T185	31.6457	5.19	Yes	Yes	1	4	4
58	R:R:N100	R:R:W105	12.7574	7.91	No	Yes	0	4	8
59	R:R:M116	R:R:T185	28.5064	3.01	No	Yes	0	5	4
60	R:R:C186	R:R:M116	25.6009	8.1	No	No	0	9	5
61	R:R:C112	R:R:C186	12.8128	7.28	Yes	No	5	9	9
62	R:R:Q123	R:R:W261	26.8259	8.76	Yes	Yes	0	7	8
63	R:R:F124	R:R:M170	11.2246	7.46	Yes	No	0	6	4
64	R:R:V127	R:R:W261	24.139	4.9	No	Yes	0	8	8
65	R:R:F257	R:R:V127	20.6457	5.24	Yes	No	0	9	8
66	R:R:N300	R:R:Y304	40.0542	8.14	Yes	Yes	1	9	9
67	R:R:Y221	R:R:Y304	14.1178	10.92	Yes	Yes	1	9	9
68	R:R:F201	R:R:G198	20.9381	1.51	Yes	No	0	5	4
69	R:R:G198	R:R:S189	19.2269	3.71	No	No	0	4	1
70	R:R:N187	R:R:S189	15.7859	4.47	No	No	0	5	1
71	R:R:N187	R:R:Q181	14.0562	9.24	No	No	0	5	1
72	R:R:D179	R:R:Q181	12.3203	6.53	No	No	0	4	1
73	R:R:D179	R:R:P191	10.5783	8.05	No	No	0	4	4
74	R:R:F210	R:R:L262	12.9605	7.31	No	No	0	8	5
75	R:R:F257	R:R:L214	13.4714	3.65	Yes	No	0	9	7
76	R:R:C218	R:R:L214	10.2213	6.35	No	No	0	4	7
77	R:R:L222	R:R:V225	10.8276	1.49	No	Yes	0	3	5
78	R:R:V253	R:R:Y304	24.2652	1.26	No	Yes	0	8	9
79	R:R:L303	R:R:V253	21.8676	5.96	Yes	No	0	8	8
80	R:R:L303	R:R:L307	14.6317	1.38	Yes	No	0	8	6
81	R:R:L307	R:R:M249	12.2034	5.65	No	No	0	6	8
82	L:L:?2	R:R:N268	56.351	8.72	Yes	Yes	1	0	5
83	L:L:?5	R:R:Y286	58.7116	13.84	Yes	No	1	0	4
84	R:R:N81	R:R:W164	11.4678	7.91	No	No	0	9	9
85	R:R:L82	R:R:N300	10.6583	6.87	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:I202	4.62	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N268	7.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N271	6.66	1	Yes	No	0	4	0	1
L:L:?2	R:R:Q123	8.45	1	Yes	Yes	0	7	0	1
L:L:?2	R:R:F124	3.87	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:F201	3.87	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:F264	4.83	1	Yes	Yes	0	7	0	1
L:L:?2	R:R:N268	8.72	1	Yes	Yes	0	5	0	1
L:L:K3	R:R:Y89	5.97	1	Yes	Yes	0	6	0	1
L:L:K3	R:R:D119	13.83	1	Yes	No	0	6	0	1
L:L:K3	R:R:F264	8.69	1	Yes	Yes	0	7	0	1
L:L:Y4	R:R:Q99	10.15	1	No	No	0	4	0	1
L:L:Y4	R:R:T185	16.23	1	No	Yes	0	4	0	1
L:L:?5	R:R:L276	5.45	1	Yes	Yes	0	1	0	1
L:L:?5	R:R:S282	5.91	1	Yes	No	0	5	0	1
L:L:?5	R:R:Y286	13.84	1	Yes	No	0	4	0	1
L:L:?6	R:R:N271	8.79	1	No	No	0	4	0	1
R:R:D119	R:R:Y89	8.05	1	No	Yes	6	6	1	1
R:R:N122	R:R:Y89	5.81	0	Yes	Yes	8	6	2	1
R:R:Q123	R:R:Y89	6.76	1	Yes	Yes	7	6	1	1
R:R:S297	R:R:Y89	6.36	1	No	Yes	9	6	2	1
R:R:F104	R:R:Q99	9.37	1	Yes	No	4	4	2	1
R:R:Q99	R:R:T185	4.25	1	No	Yes	4	4	1	1
R:R:F104	R:R:T185	5.19	1	Yes	Yes	4	4	2	1
R:R:D119	R:R:G120	5.03	1	No	No	6	5	1	2
R:R:F124	R:R:Q123	8.2	1	Yes	Yes	6	7	1	1
R:R:Q123	R:R:W261	8.76	1	Yes	Yes	7	8	1	2
R:R:F265	R:R:Q123	5.86	0	No	Yes	7	7	2	1
R:R:F124	R:R:M170	7.46	1	Yes	No	6	4	1	2
R:R:F124	R:R:T205	3.89	1	Yes	No	6	4	1	2
R:R:F201	R:R:L174	7.31	0	Yes	No	5	3	1	2
R:R:A199	R:R:L272	4.73	0	No	No	3	4	2	1
R:R:F201	R:R:I202	3.77	0	Yes	Yes	5	5	1	1
R:R:F201	R:R:T205	7.78	0	Yes	No	5	4	1	2
R:R:I202	R:R:N268	4.25	1	Yes	Yes	5	5	1	1
R:R:S293	R:R:W261	3.71	0	No	Yes	7	8	2	2
R:R:F264	R:R:F265	5.36	1	Yes	No	7	7	1	2
R:R:F264	R:R:S293	3.96	1	Yes	No	7	7	1	2
R:R:N268	R:R:V267	4.43	1	Yes	No	5	5	1	2
R:R:V267	R:R:Y286	11.36	1	No	No	5	4	2	1
R:R:N268	R:R:Y286	4.65	1	Yes	No	5	4	1	1
R:R:L276	R:R:N271	6.87	1	Yes	No	1	4	1	1
R:R:L276	R:R:S282	7.51	1	Yes	No	1	5	1	1
R:R:A283	R:R:F287	4.16	0	No	No	4	3	1	2
R:R:M116	R:R:T185	3.01	0	No	Yes	5	4	2	1
R:R:F264	R:R:V289	2.62	1	Yes	No	7	7	1	2
L:L:?5	R:R:A283	2.48	1	Yes	No	0	4	0	1
L:L:?1	R:R:L272	2.24	1	Yes	No	0	4	0	1
L:L:?5	R:R:Q278	2.09	1	Yes	No	0	1	0	1
R:R:L276	R:R:P277	1.64	1	Yes	No	1	3	1	2
R:R:F201	R:R:G198	1.51	0	Yes	No	5	4	1	2
R:R:I202	R:R:I269	1.47	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZCJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	255
Number of Links	287
Number of Hubs	38
Number of Links mediated by Hubs	140
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	75605
Length Of Smallest Path	3
Average Path Length	14.69
Length of Longest Path	29
Minimum Path Strength	1.24
Average Path Strength	7.5478
Maximum Path Strength	28.95
Minimum Path Correlation	0.7
Average Path Correlation	0.929277
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.6623
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	004
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	99291
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(R)-tryptophan DTR D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	9060
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	PHA
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	PHA
Name	PHENYLALANINAL
Synonyms
Identifier
Formula	C9 H11 N O
Molecular Weight	149.19
SMILES
PubChem	446207
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	22
Total Aromatic Bonds	6


Code	HYP
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	HYP
Name	Hydroxyproline
Synonyms	HYDROXYPROLINE
Identifier
Formula	C5 H9 N O3
Molecular Weight	131.13
SMILES
PubChem	6971053
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35346
Sequence	>8ZCJ_nogp_Chain_R V P V L Y L L V C A A G L G G N T L V I Y V V L R F A K M K T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A S F W P F G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H P L S S A R W R R P R V A K L A S A A A W V L S L C M S L P L L V F A D V Q E G G T C N A S W P E P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V G C V R R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V A L P Q E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F R Q S F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X8L	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin-14	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8L (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin-14	-		2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8ZBE	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	Gi1/β1/γ1	3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBE (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-	Gi1/β1/γ1	3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-		3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.94	2025-04-30	To be published
	8ZBJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-		2.94	2025-04-30	To be published
	9W32	A	Peptide	Somatostatin	SST5	Homo sapiens	SSTR5 antagonist 1	-	-	2.59	2026-01-21	10.1073/pnas.2522515122
	9W33	A	Peptide	Somatostatin	SST5	Homo sapiens	S5A1	-	-	2.69	2026-01-21	10.1073/pnas.2522515122

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