psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	18.65	Yes	Yes	1	0	0
2	L:L:?1	L:L:?6	21.48	Yes	No	1	0	0
3	L:L:?1	R:R:I202	4.62	Yes	Yes	1	0	5
4	L:L:?1	R:R:N268	7.77	Yes	Yes	1	0	5
5	L:L:?1	R:R:N271	6.66	Yes	No	1	0	4
6	L:L:?2	L:L:K3	12.31	Yes	Yes	1	0	0
7	L:L:?2	R:R:Q123	8.45	Yes	Yes	1	0	7
8	L:L:?2	R:R:F124	3.87	Yes	Yes	1	0	6
9	L:L:?2	R:R:F201	3.87	Yes	Yes	0	0	5
10	L:L:?2	R:R:F264	4.83	Yes	Yes	1	0	7
11	L:L:?2	R:R:N268	8.72	Yes	Yes	1	0	5
12	L:L:K3	R:R:Y89	5.97	Yes	Yes	1	0	6
13	L:L:K3	R:R:D119	13.83	Yes	No	1	0	6
14	L:L:K3	R:R:F264	8.69	Yes	Yes	1	0	7
15	L:L:?5	L:L:Y4	3.69	Yes	No	1	0	0
16	L:L:Y4	R:R:Q99	10.15	No	No	1	0	4
17	L:L:Y4	R:R:T185	16.23	No	Yes	1	0	4
18	L:L:?5	L:L:?6	31.86	Yes	No	1	0	0
19	L:L:?5	R:R:L276	5.45	Yes	Yes	1	0	1
20	L:L:?5	R:R:S282	5.91	Yes	No	1	0	5
21	L:L:?5	R:R:Y286	13.84	Yes	No	1	0	4
22	L:L:?6	R:R:N271	8.79	No	No	1	0	4
23	R:R:P44	R:R:V43	5.3	No	No	0	5	6
24	R:R:F288	R:R:V43	5.24	No	No	0	4	6
25	R:R:L49	R:R:V45	4.47	No	No	0	5	5
26	R:R:L93	R:R:Y47	19.93	No	No	0	7	7
27	R:R:V290	R:R:Y47	7.57	No	No	0	5	7
28	R:R:I291	R:R:Y47	20.55	No	No	0	5	7
29	R:R:C51	R:R:L48	3.17	Yes	No	0	6	4
30	R:R:C51	R:R:L93	3.17	Yes	No	0	6	7
31	R:R:C51	R:R:P94	7.53	Yes	No	0	6	8
32	R:R:G54	R:R:Y294	4.35	No	Yes	0	8	7
33	R:R:G56	R:R:L55	3.42	No	Yes	2	4	6
34	R:R:L55	R:R:T59	4.42	Yes	No	2	6	4
35	R:R:L55	R:R:V87	5.96	Yes	No	0	6	7
36	R:R:L55	R:R:M90	11.31	Yes	No	0	6	6
37	R:R:G56	R:R:T59	3.64	No	No	2	4	4
38	R:R:D86	R:R:N58	6.73	Yes	No	0	9	9
39	R:R:N58	R:R:V87	5.91	No	No	0	9	7
40	R:R:N58	R:R:P301	16.29	No	No	0	9	9
41	R:R:F306	R:R:L60	7.31	No	No	0	7	6
42	R:R:A83	R:R:V61	3.39	No	No	0	8	9
43	R:R:P301	R:R:V61	3.53	No	No	0	9	9
44	R:R:I62	R:R:L80	5.71	No	Yes	3	7	6
45	R:R:A83	R:R:I62	3.25	No	No	0	8	7
46	R:R:I62	R:R:V84	4.61	No	No	3	7	6
47	R:R:R67	R:R:Y63	22.64	No	No	0	4	4
48	R:R:F311	R:R:V64	11.8	Yes	No	0	8	7
49	R:R:S314	R:R:V64	3.23	Yes	No	0	5	7
50	R:R:N76	R:R:V65	14.78	No	Yes	0	8	7
51	R:R:I79	R:R:V65	4.61	No	Yes	0	8	7
52	R:R:L80	R:R:V65	4.47	Yes	Yes	0	6	7
53	R:R:F311	R:R:V65	9.18	Yes	Yes	0	8	7
54	R:R:L66	R:R:L80	6.92	No	Yes	0	3	6
55	R:R:F311	R:R:K70	9.93	Yes	No	0	8	5
56	R:R:K70	R:R:S314	10.71	No	Yes	0	5	5
57	R:R:K72	R:R:M71	5.76	No	No	0	6	7
58	R:R:K72	R:R:P153	6.69	No	No	0	6	2
59	R:R:D136	R:R:V74	5.84	No	No	4	8	6
60	R:R:R151	R:R:V74	10.46	Yes	No	4	6	6
61	R:R:A156	R:R:V74	3.39	No	No	0	7	6
62	R:R:A156	R:R:I77	4.87	No	No	0	7	6
63	R:R:V132	R:R:Y78	7.57	No	No	0	7	7
64	R:R:D136	R:R:Y78	8.05	No	No	0	8	7
65	R:R:A159	R:R:Y78	4	No	No	0	5	7
66	R:R:L80	R:R:V84	4.47	Yes	No	3	6	6
67	R:R:C129	R:R:N81	7.87	No	No	0	8	9
68	R:R:N81	R:R:S160	10.43	No	No	0	9	8
69	R:R:N81	R:R:W164	7.91	No	No	0	9	9
70	R:R:D86	R:R:L82	4.07	Yes	No	1	9	9
71	R:R:C129	R:R:L82	9.52	No	No	0	8	9
72	R:R:L82	R:R:N300	6.87	No	Yes	1	9	9
73	R:R:V84	R:R:W164	4.9	No	No	0	6	9
74	R:R:D86	R:R:S126	7.36	Yes	No	0	9	9
75	R:R:D86	R:R:N296	4.04	Yes	Yes	1	9	9
76	R:R:D86	R:R:S297	11.78	Yes	No	1	9	9
77	R:R:D86	R:R:N300	5.39	Yes	Yes	1	9	9
78	R:R:L88	R:R:L91	4.15	No	No	0	7	4
79	R:R:L88	R:R:N122	9.61	No	Yes	0	7	8
80	R:R:D119	R:R:Y89	8.05	No	Yes	1	6	6
81	R:R:N122	R:R:Y89	5.81	Yes	Yes	0	8	6
82	R:R:Q123	R:R:Y89	6.76	Yes	Yes	1	7	6
83	R:R:S297	R:R:Y89	6.36	No	Yes	1	9	6
84	R:R:L91	R:R:M90	5.65	No	No	0	4	6
85	R:R:M90	R:R:Y294	7.18	No	Yes	0	6	7
86	R:R:L93	R:R:Y294	14.07	No	Yes	0	7	7
87	R:R:F95	R:R:V115	5.24	No	No	0	6	5
88	R:R:T98	R:R:W105	4.85	No	Yes	0	4	8
89	R:R:F104	R:R:Q99	9.37	Yes	No	1	4	4
90	R:R:Q99	R:R:T185	4.25	No	Yes	1	4	4
91	R:R:N100	R:R:W105	7.91	No	Yes	0	4	8
92	R:R:F104	R:R:T185	5.19	Yes	Yes	1	4	4
93	R:R:P106	R:R:W105	4.05	No	Yes	0	3	8
94	R:R:P106	R:R:V110	10.6	No	No	0	3	2
95	R:R:G108	R:R:P109	4.06	No	No	0	8	3
96	R:R:G108	R:R:L111	5.13	No	No	0	8	5
97	R:R:V110	R:R:V115	3.21	No	No	0	2	5
98	R:R:C112	R:R:V180	5.12	Yes	No	0	9	5
99	R:R:C112	R:R:C186	7.28	Yes	No	5	9	9
100	R:R:C186	R:R:M116	8.1	No	No	0	9	5
101	R:R:S171	R:R:T117	6.4	No	No	0	7	6
102	R:R:L175	R:R:T117	10.32	No	No	0	5	6
103	R:R:D119	R:R:G120	5.03	No	No	0	6	5
104	R:R:N122	R:R:V121	4.43	Yes	Yes	0	8	5
105	R:R:S167	R:R:V121	9.7	No	Yes	0	7	5
106	R:R:S171	R:R:V121	6.46	No	Yes	0	7	5
107	R:R:F124	R:R:Q123	8.2	Yes	Yes	1	6	7
108	R:R:Q123	R:R:W261	8.76	Yes	Yes	0	7	8
109	R:R:F265	R:R:Q123	5.86	No	Yes	0	7	7
110	R:R:F124	R:R:M170	7.46	Yes	No	0	6	4
111	R:R:F124	R:R:T205	3.89	Yes	No	0	6	4
112	R:R:T125	R:R:W164	6.06	Yes	No	0	7	9
113	R:R:S167	R:R:T125	7.99	No	Yes	0	7	7
114	R:R:P213	R:R:V127	5.3	Yes	No	0	8	8
115	R:R:F257	R:R:V127	5.24	Yes	No	0	9	8
116	R:R:V127	R:R:W261	4.9	No	Yes	0	8	8
117	R:R:F128	R:R:L166	3.65	No	No	0	5	4
118	R:R:F128	R:R:L208	6.09	No	No	0	5	4
119	R:R:C129	R:R:V132	3.42	No	No	0	8	7
120	R:R:F257	R:R:L130	9.74	Yes	No	0	9	9
121	R:R:L130	R:R:Y304	9.38	No	Yes	0	9	9
122	R:R:P213	R:R:T131	3.5	Yes	No	0	8	7
123	R:R:I217	R:R:T131	12.16	No	No	0	8	7
124	R:R:M133	R:R:R137	6.2	No	Yes	1	8	9
125	R:R:M133	R:R:Y304	8.38	No	Yes	1	8	9
126	R:R:I217	R:R:S134	7.74	No	No	0	8	9
127	R:R:C220	R:R:S134	3.44	No	No	0	8	9
128	R:R:S134	R:R:Y221	6.36	No	Yes	0	9	9
129	R:R:L139	R:R:V135	4.47	No	No	0	5	6
130	R:R:D136	R:R:R151	10.72	No	Yes	4	8	6
131	R:R:R137	R:R:Y221	11.32	Yes	Yes	1	9	9
132	R:R:R137	R:R:Y304	4.12	Yes	Yes	1	9	9
133	R:R:V142	R:R:Y138	15.14	No	No	6	7	8
134	R:R:H143	R:R:Y138	9.8	No	No	6	7	8
135	R:R:C220	R:R:Y138	4.03	No	No	0	8	8
136	R:R:A140	R:R:R151	4.15	No	Yes	0	8	6
137	R:R:I224	R:R:V141	4.61	No	No	0	8	8
138	R:R:H143	R:R:V142	9.69	No	No	6	7	7
139	R:R:K227	R:R:V142	7.59	No	No	0	5	7
140	R:R:L145	R:R:P144	3.28	No	No	0	5	7
141	R:R:R151	R:R:S147	9.22	Yes	No	0	6	5
142	R:R:R149	R:R:W150	5	No	No	0	3	4
143	R:R:R152	R:R:V155	5.23	No	No	0	6	4
144	R:R:C169	R:R:L166	4.76	No	No	0	3	4
145	R:R:L174	R:R:S171	4.5	No	No	0	3	7
146	R:R:F201	R:R:L174	7.31	Yes	No	0	5	3
147	R:R:F177	R:R:W190	40.09	No	No	0	4	6
148	R:R:D179	R:R:Q181	6.53	No	No	0	4	1
149	R:R:D179	R:R:P191	8.05	No	No	0	4	4
150	R:R:N187	R:R:Q181	9.24	No	No	0	5	1
151	R:R:N187	R:R:S189	4.47	No	No	0	5	1
152	R:R:S189	R:R:V194	4.85	No	No	0	1	2
153	R:R:G198	R:R:S189	3.71	No	No	0	4	1
154	R:R:P191	R:R:W190	4.05	No	No	0	4	6
155	R:R:W190	R:R:W197	17.81	No	No	0	6	3
156	R:R:E192	R:R:P193	9.43	No	No	0	3	4
157	R:R:P193	R:R:W197	5.4	No	No	0	4	3
158	R:R:A199	R:R:L272	4.73	No	No	0	3	4
159	R:R:V200	R:R:Y204	6.31	No	No	0	4	3
160	R:R:F201	R:R:I202	3.77	Yes	Yes	0	5	5
161	R:R:F201	R:R:T205	7.78	Yes	No	0	5	4
162	R:R:I202	R:R:N268	4.25	Yes	Yes	1	5	5
163	R:R:I203	R:R:Y204	3.63	No	No	0	5	3
164	R:R:F211	R:R:V207	10.49	No	No	0	5	5
165	R:R:F210	R:R:W261	8.02	No	Yes	0	8	8
166	R:R:F210	R:R:L262	7.31	No	No	0	8	5
167	R:R:F210	R:R:F265	6.43	No	No	0	8	7
168	R:R:C218	R:R:L214	6.35	No	No	0	4	7
169	R:R:F257	R:R:L214	3.65	Yes	No	0	9	7
170	R:R:C218	R:R:V254	5.12	No	No	0	4	7
171	R:R:V250	R:R:Y221	10.09	No	Yes	0	7	9
172	R:R:Y221	R:R:Y304	10.92	Yes	Yes	1	9	9
173	R:R:S242	R:R:V228	3.23	No	No	0	5	8
174	R:R:E243	R:R:V228	4.28	No	No	0	6	8
175	R:R:E243	R:R:R229	4.65	No	No	0	6	4
176	R:R:R234	R:R:V235	5.23	No	No	0	2	4
177	R:R:G236	R:R:V235	3.68	No	No	0	3	4
178	R:R:R239	R:R:R241	9.6	No	No	0	3	4
179	R:R:E243	R:R:R240	16.28	No	No	0	6	3
180	R:R:L307	R:R:M249	5.65	No	No	0	6	8
181	R:R:M249	R:R:S308	4.6	No	No	0	8	8
182	R:R:L303	R:R:V253	5.96	Yes	No	0	8	8
183	R:R:F257	R:R:N296	9.67	Yes	Yes	0	9	9
184	R:R:C260	R:R:L292	4.76	No	No	0	8	7
185	R:R:A295	R:R:C260	3.61	No	No	0	5	8
186	R:R:S293	R:R:W261	3.71	No	Yes	0	7	8
187	R:R:L262	R:R:P263	3.28	No	No	0	5	9
188	R:R:L262	R:R:T266	7.37	No	No	0	5	6
189	R:R:L292	R:R:P263	3.28	No	No	0	7	9
190	R:R:F264	R:R:F265	5.36	Yes	No	0	7	7
191	R:R:F264	R:R:S293	3.96	Yes	No	0	7	7
192	R:R:N268	R:R:V267	4.43	Yes	No	1	5	5
193	R:R:V267	R:R:Y286	11.36	No	No	1	5	4
194	R:R:N268	R:R:Y286	4.65	Yes	No	1	5	4
195	R:R:L276	R:R:N271	6.87	Yes	No	1	1	4
196	R:R:L276	R:R:S282	7.51	Yes	No	1	1	5
197	R:R:E279	R:R:P277	9.43	No	No	0	2	3
198	R:R:A283	R:R:F287	4.16	No	No	0	4	3
199	R:R:F287	R:R:G284	6.02	No	No	0	3	1
200	R:R:F288	R:R:I291	3.77	No	No	0	4	5
201	R:R:C298	R:R:Y294	5.38	No	Yes	0	8	7
202	R:R:N296	R:R:S297	5.96	Yes	No	1	9	9
203	R:R:N296	R:R:N300	9.54	Yes	Yes	1	9	9
204	R:R:N300	R:R:Y304	8.14	Yes	Yes	1	9	9
205	R:R:F306	R:R:F311	6.43	No	Yes	0	7	8
206	R:R:F306	R:R:F315	13.93	No	No	0	7	6
207	R:R:F315	R:R:R312	11.76	No	No	0	6	8
208	R:R:F315	R:R:Q316	15.23	No	No	0	6	4
209	R:R:A101	R:R:N100	3.13	No	No	0	4	4
210	R:R:I79	R:R:T75	3.04	No	No	0	8	7
211	R:R:M116	R:R:T185	3.01	No	Yes	0	5	4
212	R:R:L46	R:R:V50	2.98	No	No	0	5	7
213	R:R:L168	R:R:V121	2.98	No	Yes	0	4	5
214	R:R:L172	R:R:V176	2.98	No	No	0	5	4
215	R:R:L196	R:R:V200	2.98	No	No	0	1	4
216	R:R:L208	R:R:V207	2.98	No	No	0	4	5
217	R:R:L219	R:R:V254	2.98	No	No	0	4	7
218	R:R:L285	R:R:V289	2.98	No	No	0	5	7
219	R:R:L251	R:R:T247	2.95	No	No	0	4	6
220	R:R:Q313	R:R:S314	2.89	No	Yes	0	4	5
221	R:R:L208	R:R:M170	2.83	No	No	0	4	4
222	R:R:L251	R:R:L255	2.77	No	No	0	4	4
223	R:R:L118	R:R:N122	2.75	No	Yes	0	5	8
224	R:R:F68	R:R:S314	2.64	No	Yes	0	5	5
225	R:R:R229	R:R:V226	2.62	No	No	0	4	3
226	R:R:F264	R:R:V289	2.62	Yes	No	0	7	7
227	R:R:V50	R:R:Y294	2.52	No	Yes	0	7	7
228	R:R:I224	R:R:R137	2.51	No	Yes	0	8	9
229	L:L:?5	R:R:A283	2.48	Yes	No	0	0	4
230	R:R:M249	R:R:R248	2.48	No	No	0	8	5
231	R:R:F104	R:R:L96	2.44	Yes	No	0	4	6
232	R:R:L139	R:R:R151	2.43	No	Yes	0	5	6
233	R:R:M170	R:R:Y204	2.39	No	No	0	4	3
234	L:L:?1	R:R:L272	2.24	Yes	No	0	0	4
235	R:R:G56	R:R:G57	2.11	No	No	0	4	8
236	R:R:G183	R:R:G184	2.11	No	No	0	1	4
237	L:L:?5	R:R:Q278	2.09	Yes	No	0	0	1
238	R:R:G92	R:R:P94	2.03	No	No	0	6	8
239	R:R:G209	R:R:P213	2.03	No	Yes	0	5	8
240	R:R:F104	R:R:W105	2	Yes	Yes	0	4	8
241	R:R:A53	R:R:G54	1.95	No	No	0	5	8
242	R:R:A102	R:R:G184	1.95	No	No	0	3	4
243	R:R:A231	R:R:G232	1.95	No	No	0	5	4
244	R:R:A258	R:R:G259	1.95	No	No	0	5	5
245	R:R:A212	R:R:P213	1.87	No	Yes	0	5	8
246	R:R:A52	R:R:C51	1.81	No	Yes	0	5	6
247	R:R:A178	R:R:C112	1.81	No	Yes	0	5	9
248	R:R:A178	R:R:A188	1.79	No	No	0	5	3
249	R:R:P144	R:R:S147	1.78	No	No	0	7	5
250	R:R:G305	R:R:I79	1.76	No	No	0	7	8
251	R:R:A85	R:R:T125	1.68	No	Yes	0	8	7
252	R:R:A163	R:R:T125	1.68	No	Yes	0	6	7
253	R:R:L172	R:R:P173	1.64	No	No	0	5	7
254	R:R:L276	R:R:P277	1.64	Yes	No	0	1	3
255	R:R:V225	R:R:V226	1.6	Yes	No	0	5	3
256	R:R:V225	R:R:V246	1.6	Yes	No	7	5	7
257	R:R:C112	R:R:L111	1.59	Yes	No	5	9	5
258	R:R:C186	R:R:L111	1.59	No	No	5	9	5
259	R:R:T247	R:R:V225	1.59	No	Yes	7	6	5
260	R:R:T247	R:R:V246	1.59	No	No	7	6	7
261	R:R:A258	R:R:L214	1.58	No	No	0	5	7
262	R:R:E279	R:R:P280	1.57	No	No	0	2	1
263	R:R:I217	R:R:V216	1.54	No	No	0	8	7
264	R:R:F201	R:R:G198	1.51	Yes	No	0	5	4
265	R:R:A281	R:R:E279	1.51	No	No	0	1	2
266	R:R:L222	R:R:V225	1.49	No	Yes	0	3	5
267	R:R:L222	R:R:V250	1.49	No	No	0	3	7
268	R:R:L222	R:R:V254	1.49	No	No	0	3	7
269	R:R:L303	R:R:V252	1.49	Yes	No	0	8	6
270	R:R:L303	R:R:V256	1.49	Yes	No	0	8	6
271	R:R:I202	R:R:I269	1.47	Yes	No	0	5	6
272	R:R:I203	R:R:I269	1.47	No	No	0	5	6
273	R:R:N76	R:R:T73	1.46	No	No	0	8	7
274	R:R:I77	R:R:K157	1.45	No	No	0	6	3
275	R:R:P153	R:R:R152	1.44	No	No	0	2	6
276	R:R:M71	R:R:N76	1.4	No	No	0	7	8
277	R:R:H143	R:R:S146	1.39	No	No	0	7	4
278	R:R:L48	R:R:L49	1.38	No	No	0	4	5
279	R:R:L114	R:R:L118	1.38	No	No	0	5	5
280	R:R:L215	R:R:L219	1.38	No	No	0	3	4
281	R:R:L303	R:R:L307	1.38	Yes	No	0	8	6
282	R:R:V253	R:R:Y304	1.26	No	Yes	0	8	9
283	R:R:F68	R:R:K317	1.24	No	No	0	5	4
284	R:R:K245	R:R:R244	1.24	No	No	0	7	4
285	R:R:K245	R:R:R248	1.24	No	No	0	7	5
286	R:R:D309	R:R:R312	1.19	No	No	0	5	8
287	R:R:R149	R:R:R152	1.07	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.2367	6	1	0
2	L:L:?2	8.67143	7	1	0
3	L:L:K3	10.2	4	1	0
4	L:L:?5	9.33143	7	1	0
5	R:R:C51	3.92	4	0	6
6	R:R:L55	6.2775	4	2	6
7	R:R:V65	8.26	4	0	7
8	R:R:L80	5.3925	4	3	6
9	R:R:D86	6.56167	6	1	9
10	R:R:Y89	6.59	5	1	6
11	R:R:F104	4.75	4	1	4
12	R:R:W105	4.7025	4	0	8
13	R:R:C112	3.95	4	5	9
14	R:R:V121	5.8925	4	0	5
15	R:R:N122	5.65	4	0	8
16	R:R:Q123	7.606	5	1	7
17	R:R:F124	5.855	4	1	6
18	R:R:T125	4.3525	4	0	7
19	R:R:R137	6.0375	4	1	9
20	R:R:R151	7.396	5	4	6
21	R:R:T185	7.17	4	1	4
22	R:R:F201	4.848	5	0	5
23	R:R:I202	3.5275	4	1	5
24	R:R:P213	3.175	4	0	8
25	R:R:Y221	9.6725	4	1	9
26	R:R:V225	1.57	4	7	5
27	R:R:F257	7.075	4	0	9
28	R:R:W261	6.3475	4	0	8
29	R:R:F264	5.092	5	1	7
30	R:R:N268	5.964	5	1	5
31	R:R:L276	5.3675	4	1	1
32	R:R:Y294	6.7	5	0	7
33	R:R:N296	7.3025	4	1	9
34	R:R:N300	7.485	4	1	9
35	R:R:L303	2.58	4	0	8
36	R:R:Y304	7.03333	6	1	9
37	R:R:F311	9.335	4	0	8
38	R:R:S314	4.8675	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	67.354	18.65	Yes	Yes	1	0	0
2	L:L:?2	L:L:K3	46.1266	12.31	Yes	Yes	1	0	0
3	L:L:?2	R:R:Q123	68.4405	8.45	Yes	Yes	1	0	7
4	L:L:?2	R:R:F201	30.5931	3.87	Yes	Yes	0	0	5
5	L:L:?1	R:R:I202	11.5109	4.62	Yes	Yes	1	0	5
6	R:R:F201	R:R:I202	18.956	3.77	Yes	Yes	0	5	5
7	L:L:K3	R:R:Y89	47.1084	5.97	Yes	Yes	1	0	6
8	R:R:Q123	R:R:Y89	57.2928	6.76	Yes	Yes	1	7	6
9	L:L:?1	L:L:?6	60.2228	21.48	Yes	No	1	0	0
10	L:L:?5	L:L:?6	58.9148	31.86	Yes	No	1	0	0
11	L:L:?5	L:L:Y4	100	3.69	Yes	No	1	0	0
12	L:L:Y4	R:R:Q99	34.5049	10.15	No	No	1	0	4
13	L:L:Y4	R:R:T185	62.4234	16.23	No	Yes	1	0	4
14	L:L:?1	R:R:N271	10.923	6.66	Yes	No	1	0	4
15	R:R:N268	R:R:Y286	59.8904	4.65	Yes	No	1	5	4
16	R:R:N122	R:R:Y89	56.1017	5.81	Yes	Yes	0	8	6
17	R:R:L88	R:R:N122	25.3947	9.61	No	Yes	0	7	8
18	R:R:L88	R:R:L91	24.099	4.15	No	No	0	7	4
19	R:R:L91	R:R:M90	22.9879	5.65	No	No	0	4	6
20	R:R:M90	R:R:Y294	25.7271	7.18	No	Yes	0	6	7
21	R:R:L93	R:R:Y294	18.2666	14.07	No	Yes	0	7	7
22	R:R:L55	R:R:M90	11.5478	11.31	Yes	No	0	6	6
23	R:R:S297	R:R:Y89	57.1143	6.36	No	Yes	1	9	6
24	R:R:D86	R:R:S297	40.1126	11.78	Yes	No	1	9	9
25	R:R:D86	R:R:N58	17.3987	6.73	Yes	No	0	9	9
26	R:R:N58	R:R:V87	13.5853	5.91	No	No	0	9	7
27	R:R:L55	R:R:V87	12.4711	5.96	Yes	No	0	6	7
28	R:R:N122	R:R:V121	33.0307	4.43	Yes	Yes	0	8	5
29	R:R:S167	R:R:V121	52.553	9.7	No	Yes	0	7	5
30	R:R:S167	R:R:T125	51.1188	7.99	No	Yes	0	7	7
31	R:R:T125	R:R:W164	47.9148	6.06	Yes	No	0	7	9
32	R:R:V84	R:R:W164	54.966	4.9	No	No	0	6	9
33	R:R:L80	R:R:V84	51.6605	4.47	Yes	No	3	6	6
34	R:R:L80	R:R:V65	53.027	4.47	Yes	Yes	0	6	7
35	R:R:F311	R:R:V65	30.7439	9.18	Yes	Yes	0	8	7
36	R:R:F306	R:R:F311	11.1138	6.43	No	Yes	0	7	8
37	R:R:F201	R:R:L174	29.8637	7.31	Yes	No	0	5	3
38	R:R:L174	R:R:S171	29.2173	4.5	No	No	0	3	7
39	R:R:S171	R:R:V121	28.8757	6.46	No	Yes	0	7	5
40	R:R:N76	R:R:V65	16.4169	14.78	No	Yes	0	8	7
41	R:R:M71	R:R:N76	12.7728	1.4	No	No	0	7	8
42	R:R:K72	R:R:M71	10.9415	5.76	No	No	0	6	7
43	R:R:D86	R:R:L82	20.378	4.07	Yes	No	1	9	9
44	R:R:C129	R:R:L82	29.996	9.52	No	No	0	8	9
45	R:R:C129	R:R:V132	20.1717	3.42	No	No	0	8	7
46	R:R:V132	R:R:Y78	18.8698	7.57	No	No	0	7	7
47	R:R:D136	R:R:Y78	16.2445	8.05	No	No	0	8	7
48	R:R:C129	R:R:N81	13.2529	7.87	No	No	0	8	9
49	R:R:D86	R:R:N300	19.033	5.39	Yes	Yes	1	9	9
50	R:R:N296	R:R:S297	16.777	5.96	Yes	No	1	9	9
51	R:R:N296	R:R:N300	17.9465	9.54	Yes	Yes	1	9	9
52	R:R:F104	R:R:Q99	31.6365	9.37	Yes	No	1	4	4
53	R:R:F104	R:R:W105	50.891	2	Yes	Yes	0	4	8
54	R:R:P106	R:R:W105	25.4932	4.05	No	Yes	0	3	8
55	R:R:P106	R:R:V110	19.1284	10.6	No	No	0	3	2
56	R:R:V110	R:R:V115	12.7574	3.21	No	No	0	2	5
57	R:R:F104	R:R:T185	31.6457	5.19	Yes	Yes	1	4	4
58	R:R:N100	R:R:W105	12.7574	7.91	No	Yes	0	4	8
59	R:R:M116	R:R:T185	28.5064	3.01	No	Yes	0	5	4
60	R:R:C186	R:R:M116	25.6009	8.1	No	No	0	9	5
61	R:R:C112	R:R:C186	12.8128	7.28	Yes	No	5	9	9
62	R:R:Q123	R:R:W261	26.8259	8.76	Yes	Yes	0	7	8
63	R:R:F124	R:R:M170	11.2246	7.46	Yes	No	0	6	4
64	R:R:V127	R:R:W261	24.139	4.9	No	Yes	0	8	8
65	R:R:F257	R:R:V127	20.6457	5.24	Yes	No	0	9	8
66	R:R:N300	R:R:Y304	40.0542	8.14	Yes	Yes	1	9	9
67	R:R:Y221	R:R:Y304	14.1178	10.92	Yes	Yes	1	9	9
68	R:R:F201	R:R:G198	20.9381	1.51	Yes	No	0	5	4
69	R:R:G198	R:R:S189	19.2269	3.71	No	No	0	4	1
70	R:R:N187	R:R:S189	15.7859	4.47	No	No	0	5	1
71	R:R:N187	R:R:Q181	14.0562	9.24	No	No	0	5	1
72	R:R:D179	R:R:Q181	12.3203	6.53	No	No	0	4	1
73	R:R:D179	R:R:P191	10.5783	8.05	No	No	0	4	4
74	R:R:F210	R:R:L262	12.9605	7.31	No	No	0	8	5
75	R:R:F257	R:R:L214	13.4714	3.65	Yes	No	0	9	7
76	R:R:C218	R:R:L214	10.2213	6.35	No	No	0	4	7
77	R:R:L222	R:R:V225	10.8276	1.49	No	Yes	0	3	5
78	R:R:V253	R:R:Y304	24.2652	1.26	No	Yes	0	8	9
79	R:R:L303	R:R:V253	21.8676	5.96	Yes	No	0	8	8
80	R:R:L303	R:R:L307	14.6317	1.38	Yes	No	0	8	6
81	R:R:L307	R:R:M249	12.2034	5.65	No	No	0	6	8
82	L:L:?2	R:R:N268	56.351	8.72	Yes	Yes	1	0	5
83	L:L:?5	R:R:Y286	58.7116	13.84	Yes	No	1	0	4
84	R:R:N81	R:R:W164	11.4678	7.91	No	No	0	9	9
85	R:R:L82	R:R:N300	10.6583	6.87	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:I202	4.62	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N268	7.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N271	6.66	1	Yes	No	0	4	0	1
L:L:?2	R:R:Q123	8.45	1	Yes	Yes	0	7	0	1
L:L:?2	R:R:F124	3.87	1	Yes	Yes	0	6	0	1
L:L:?2	R:R:F201	3.87	1	Yes	Yes	0	5	0	1
L:L:?2	R:R:F264	4.83	1	Yes	Yes	0	7	0	1
L:L:?2	R:R:N268	8.72	1	Yes	Yes	0	5	0	1
L:L:K3	R:R:Y89	5.97	1	Yes	Yes	0	6	0	1
L:L:K3	R:R:D119	13.83	1	Yes	No	0	6	0	1
L:L:K3	R:R:F264	8.69	1	Yes	Yes	0	7	0	1
L:L:Y4	R:R:Q99	10.15	1	No	No	0	4	0	1
L:L:Y4	R:R:T185	16.23	1	No	Yes	0	4	0	1
L:L:?5	R:R:L276	5.45	1	Yes	Yes	0	1	0	1
L:L:?5	R:R:S282	5.91	1	Yes	No	0	5	0	1
L:L:?5	R:R:Y286	13.84	1	Yes	No	0	4	0	1
L:L:?6	R:R:N271	8.79	1	No	No	0	4	0	1
R:R:D119	R:R:Y89	8.05	1	No	Yes	6	6	1	1
R:R:N122	R:R:Y89	5.81	0	Yes	Yes	8	6	2	1
R:R:Q123	R:R:Y89	6.76	1	Yes	Yes	7	6	1	1
R:R:S297	R:R:Y89	6.36	1	No	Yes	9	6	2	1
R:R:F104	R:R:Q99	9.37	1	Yes	No	4	4	2	1
R:R:Q99	R:R:T185	4.25	1	No	Yes	4	4	1	1
R:R:F104	R:R:T185	5.19	1	Yes	Yes	4	4	2	1
R:R:D119	R:R:G120	5.03	1	No	No	6	5	1	2
R:R:F124	R:R:Q123	8.2	1	Yes	Yes	6	7	1	1
R:R:Q123	R:R:W261	8.76	1	Yes	Yes	7	8	1	2
R:R:F265	R:R:Q123	5.86	0	No	Yes	7	7	2	1
R:R:F124	R:R:M170	7.46	1	Yes	No	6	4	1	2
R:R:F124	R:R:T205	3.89	1	Yes	No	6	4	1	2
R:R:F201	R:R:L174	7.31	0	Yes	No	5	3	1	2
R:R:A199	R:R:L272	4.73	0	No	No	3	4	2	1
R:R:F201	R:R:I202	3.77	0	Yes	Yes	5	5	1	1
R:R:F201	R:R:T205	7.78	0	Yes	No	5	4	1	2
R:R:I202	R:R:N268	4.25	1	Yes	Yes	5	5	1	1
R:R:S293	R:R:W261	3.71	0	No	Yes	7	8	2	2
R:R:F264	R:R:F265	5.36	1	Yes	No	7	7	1	2
R:R:F264	R:R:S293	3.96	1	Yes	No	7	7	1	2
R:R:N268	R:R:V267	4.43	1	Yes	No	5	5	1	2
R:R:V267	R:R:Y286	11.36	1	No	No	5	4	2	1
R:R:N268	R:R:Y286	4.65	1	Yes	No	5	4	1	1
R:R:L276	R:R:N271	6.87	1	Yes	No	1	4	1	1
R:R:L276	R:R:S282	7.51	1	Yes	No	1	5	1	1
R:R:A283	R:R:F287	4.16	0	No	No	4	3	1	2
R:R:M116	R:R:T185	3.01	0	No	Yes	5	4	2	1
R:R:F264	R:R:V289	2.62	1	Yes	No	7	7	1	2
L:L:?5	R:R:A283	2.48	1	Yes	No	0	4	0	1
L:L:?1	R:R:L272	2.24	1	Yes	No	0	4	0	1
L:L:?5	R:R:Q278	2.09	1	Yes	No	0	1	0	1
R:R:L276	R:R:P277	1.64	1	Yes	No	1	3	1	2
R:R:F201	R:R:G198	1.51	0	Yes	No	5	4	1	2
R:R:I202	R:R:I269	1.47	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZCJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	255
Number of Links	287
Number of Hubs	38
Number of Links mediated by Hubs	140
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	75605
Length Of Smallest Path	3
Average Path Length	14.69
Length of Longest Path	29
Minimum Path Strength	1.24
Average Path Strength	7.5478
Maximum Path Strength	28.95
Minimum Path Correlation	0.7
Average Path Correlation	0.929277
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.6623
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.3508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • amide binding • amyloid-beta binding • peptide binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • peptide receptor activity • G protein-coupled peptide receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • energy homeostasis • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • ossification • biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • bone mineralization • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • cellular component organization • autophagosome maturation • cellular component organization or biogenesis • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to amyloid-beta • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • neuropeptide signaling pathway • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • cell cycle process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • negative regulation of cell population proliferation • regulation of cell population proliferation • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • response to corticosteroid • response to steroid hormone • cellular response to steroid hormone stimulus • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • endosome membrane • endosome • apical part of cell • apical plasma membrane • mitotic spindle • spindle • early endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	004
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	6931074
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	PHA
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	PHA
Name	PHENYLALANINAL
Synonyms
Identifier
Formula	C9 H11 N O
Molecular Weight	149.19
SMILES
PubChem	446207
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	22
Total Aromatic Bonds	6


Code	HYP
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	HYP
Name	Hydroxyproline
Synonyms	HYDROXYPROLINE
Identifier
Formula	C5 H9 N O3
Molecular Weight	131.13
SMILES
PubChem	5810
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35346
Sequence	>8ZCJ_nogp_Chain_R V P V L Y L L V C A A G L G G N T L V I Y V V L R F A K M K T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A S F W P F G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H P L S S A R W R R P R V A K L A S A A A W V L S L C M S L P L L V F A D V Q E G G T C N A S W P E P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V G C V R R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V A L P Q E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F R Q S F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZBE	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	Gi1/β1/γ1	3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBE (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-	Gi1/β1/γ1	3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-		3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8X8L	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8L (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-		2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8ZBJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.94	2025-04-30	To be published
	8ZBJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-		2.94	2025-04-30	To be published

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