psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P44	R:R:V43	5.3	No	No	0	5	6
2	R:R:F287	R:R:L46	2.44	Yes	No	0	3	5
3	R:R:A97	R:R:Y47	4	No	Yes	0	6	7
4	R:R:F287	R:R:Y47	10.32	Yes	Yes	0	3	7
5	R:R:M90	R:R:V50	3.04	No	No	0	6	7
6	R:R:C51	R:R:L55	3.17	No	No	0	6	6
7	R:R:C51	R:R:M90	3.24	No	No	0	6	6
8	R:R:C51	R:R:L93	6.35	No	No	0	6	7
9	R:R:A53	R:R:G54	1.95	No	No	5	5	8
10	R:R:A53	R:R:C298	1.81	No	No	5	5	8
11	R:R:C298	R:R:G54	1.96	No	No	5	8	8
12	R:R:G56	R:R:L55	1.71	No	No	0	4	6
13	R:R:G56	R:R:G57	2.11	No	No	0	4	8
14	R:R:G56	R:R:T59	1.82	No	No	0	4	4
15	R:R:A83	R:R:N58	1.56	No	Yes	0	8	9
16	R:R:D86	R:R:N58	4.04	Yes	Yes	0	9	9
17	R:R:N58	R:R:V87	5.91	Yes	No	0	9	7
18	R:R:N58	R:R:P301	4.89	Yes	No	0	9	9
19	R:R:L60	R:R:Y63	4.69	No	No	0	6	4
20	R:R:V61	R:R:V65	1.6	No	No	0	9	7
21	R:R:V64	R:R:Y63	7.57	No	No	0	7	4
22	R:R:R67	R:R:Y63	3.09	No	No	0	4	4
23	R:R:F315	R:R:V64	5.24	No	No	0	6	7
24	R:R:F68	R:R:R67	14.97	No	No	0	5	4
25	R:R:A69	R:R:N76	1.56	No	Yes	0	5	8
26	R:R:I77	R:R:M71	4.37	Yes	No	0	6	7
27	R:R:T73	R:R:T75	3.14	No	No	0	7	7
28	R:R:N76	R:R:T73	4.39	Yes	No	0	8	7
29	R:R:V74	R:R:Y78	3.79	No	Yes	4	6	7
30	R:R:R151	R:R:V74	2.62	No	No	0	6	6
31	R:R:A156	R:R:V74	1.7	No	No	4	7	6
32	R:R:I79	R:R:N76	4.25	No	Yes	0	8	8
33	R:R:I77	R:R:Y78	8.46	Yes	Yes	4	6	7
34	R:R:A156	R:R:I77	3.25	No	Yes	4	7	6
35	R:R:I77	R:R:K157	2.91	Yes	No	0	6	3
36	R:R:V132	R:R:Y78	2.52	No	Yes	0	7	7
37	R:R:M133	R:R:Y78	4.79	No	Yes	0	8	7
38	R:R:D136	R:R:Y78	6.9	No	Yes	0	8	7
39	R:R:A156	R:R:Y78	4	No	Yes	4	7	7
40	R:R:C129	R:R:N81	1.57	No	Yes	0	8	9
41	R:R:N81	R:R:S160	4.47	Yes	No	0	9	8
42	R:R:N81	R:R:W164	4.52	Yes	No	0	9	9
43	R:R:D86	R:R:L82	2.71	Yes	No	0	9	9
44	R:R:C129	R:R:L82	4.76	No	No	0	8	9
45	R:R:A85	R:R:T125	1.68	No	No	0	8	7
46	R:R:D86	R:R:S297	5.89	Yes	No	0	9	9
47	R:R:D86	R:R:N300	2.69	Yes	Yes	0	9	9
48	R:R:L88	R:R:N122	5.49	No	No	0	7	8
49	R:R:N122	R:R:Y89	5.81	No	Yes	0	8	6
50	R:R:Q123	R:R:Y89	7.89	No	Yes	0	7	6
51	R:R:Y294	R:R:Y89	8.94	No	Yes	0	7	6
52	R:R:S297	R:R:Y89	2.54	No	Yes	0	9	6
53	R:R:G92	R:R:P94	2.03	No	No	0	6	8
54	R:R:L93	R:R:P94	6.57	No	No	0	7	8
55	R:R:F95	R:R:V115	6.55	No	No	0	6	5
56	L:L:T6	R:R:L96	4.42	No	No	0	0	6
57	R:R:P106	R:R:T98	3.5	No	No	0	3	4
58	R:R:N100	R:R:Q99	10.56	No	No	0	4	4
59	R:R:Q99	R:R:W105	6.57	No	Yes	0	4	8
60	R:R:Q99	R:R:T185	2.83	No	No	0	4	4
61	L:L:T6	R:R:N100	4.39	No	No	0	0	4
62	R:R:P106	R:R:W105	5.4	No	Yes	1	3	8
63	R:R:F107	R:R:W105	5.01	Yes	Yes	1	7	8
64	R:R:C112	R:R:W105	9.14	No	Yes	1	9	8
65	R:R:E182	R:R:W105	4.36	No	Yes	0	4	8
66	R:R:C186	R:R:W105	19.59	No	Yes	1	9	8
67	R:R:F107	R:R:P106	8.67	Yes	No	1	7	3
68	R:R:F107	R:R:L111	4.87	Yes	No	0	7	5
69	R:R:G108	R:R:P109	4.06	No	No	0	8	3
70	R:R:L111	R:R:V110	2.98	No	No	0	5	2
71	R:R:C112	R:R:V180	3.42	No	Yes	1	9	5
72	R:R:C112	R:R:C186	7.28	No	No	1	9	9
73	R:R:L175	R:R:R113	3.64	No	Yes	0	5	6
74	R:R:D179	R:R:R113	13.1	No	Yes	1	4	6
75	R:R:R113	R:R:V180	2.62	Yes	Yes	1	6	5
76	R:R:M116	R:R:V180	3.04	No	Yes	0	5	5
77	R:R:L175	R:R:T117	2.95	No	No	0	5	6
78	R:R:L118	R:R:N122	2.75	No	No	0	5	8
79	R:R:D119	R:R:G120	3.35	No	No	0	6	5
80	R:R:S167	R:R:V121	1.62	Yes	No	0	7	5
81	R:R:L168	R:R:V121	4.47	No	No	0	4	5
82	R:R:S171	R:R:V121	1.62	No	No	0	7	5
83	R:R:F124	R:R:Q123	8.2	No	No	0	6	7
84	L:L:?4	R:R:Q123	2.11	No	No	0	0	7
85	R:R:F124	R:R:S167	2.64	No	Yes	0	6	7
86	R:R:F124	R:R:M170	2.49	No	No	0	6	4
87	R:R:S167	R:R:T125	4.8	Yes	No	0	7	7
88	R:R:F128	R:R:V127	7.87	No	No	0	5	8
89	R:R:F257	R:R:L130	2.44	No	No	0	9	9
90	R:R:L130	R:R:N300	2.75	No	Yes	0	9	9
91	R:R:L130	R:R:Y304	2.34	No	No	0	9	9
92	R:R:P213	R:R:T131	1.75	No	No	0	8	7
93	R:R:T131	R:R:V216	3.17	No	No	0	7	7
94	R:R:M133	R:R:R137	2.48	No	No	0	8	9
95	R:R:M133	R:R:Y304	3.59	No	No	0	8	9
96	R:R:S134	R:R:V135	1.62	No	No	0	9	6
97	R:R:I217	R:R:S134	3.1	No	No	0	8	9
98	R:R:C220	R:R:S134	5.16	No	No	0	8	9
99	R:R:L139	R:R:V135	2.98	No	No	0	5	6
100	R:R:D136	R:R:R151	4.76	No	No	0	8	6
101	R:R:R137	R:R:Y221	3.09	No	Yes	0	9	9
102	R:R:L139	R:R:Y138	3.52	No	Yes	0	5	8
103	R:R:V142	R:R:Y138	13.88	No	Yes	0	7	8
104	R:R:C220	R:R:Y138	2.69	No	Yes	0	8	8
105	R:R:L223	R:R:Y138	8.21	No	Yes	0	4	8
106	R:R:A140	R:R:V141	1.7	No	No	0	8	8
107	R:R:A140	R:R:R151	2.77	No	No	0	8	6
108	R:R:H143	R:R:V142	6.92	No	No	0	7	7
109	R:R:R149	R:R:W150	23.99	No	No	0	3	4
110	R:R:R149	R:R:R152	5.33	No	No	0	3	6
111	R:R:C169	R:R:L166	1.59	No	No	0	3	4
112	R:R:L172	R:R:P173	3.28	No	No	0	5	7
113	R:R:L172	R:R:V176	4.47	No	No	0	5	4
114	R:R:P173	R:R:Y204	2.78	No	Yes	0	7	3
115	R:R:F177	R:R:W190	6.01	No	Yes	2	4	6
116	R:R:F177	R:R:P191	7.22	No	No	2	4	4
117	R:R:F177	R:R:W197	7.02	No	Yes	2	4	3
118	R:R:A178	R:R:W190	5.19	No	Yes	2	5	6
119	R:R:A178	R:R:P191	3.74	No	No	2	5	4
120	R:R:D179	R:R:V180	2.92	No	Yes	1	4	5
121	R:R:C186	R:R:V180	1.71	No	Yes	1	9	5
122	R:R:Q181	R:R:S189	10.11	No	No	0	1	1
123	R:R:E182	R:R:G183	1.64	No	No	0	4	1
124	R:R:G183	R:R:G184	2.11	No	No	0	1	4
125	R:R:G184	R:R:T185	3.64	No	No	0	4	4
126	R:R:N187	R:R:T185	4.39	No	No	0	5	4
127	L:L:C7	R:R:N187	4.72	No	No	0	0	5
128	R:R:A188	R:R:W190	2.59	No	Yes	0	3	6
129	R:R:P191	R:R:W190	2.7	No	Yes	2	4	6
130	R:R:W190	R:R:W197	4.69	Yes	Yes	2	6	3
131	L:L:F3	R:R:W190	4.01	Yes	Yes	0	0	6
132	R:R:E192	R:R:P193	6.29	No	No	0	3	4
133	R:R:E192	R:R:W197	8.72	No	Yes	0	3	3
134	R:R:G195	R:R:V194	3.68	No	No	0	3	2
135	R:R:V200	R:R:W197	2.45	No	Yes	0	4	3
136	R:R:A199	R:R:L272	1.58	No	No	0	3	4
137	R:R:F201	R:R:Y204	8.25	No	Yes	7	5	3
138	R:R:F201	R:R:T205	5.19	No	No	7	5	4
139	L:L:F3	R:R:F201	5.36	Yes	No	0	0	5
140	R:R:I202	R:R:L272	2.85	No	No	0	5	4
141	L:L:F3	R:R:I202	3.77	Yes	No	0	0	5
142	R:R:T205	R:R:Y204	6.24	No	Yes	7	4	3
143	R:R:A206	R:R:F265	2.77	No	Yes	0	4	7
144	R:R:F210	R:R:F211	2.14	Yes	No	0	8	5
145	R:R:F210	R:R:W261	4.01	Yes	Yes	8	8	8
146	R:R:F210	R:R:L262	2.44	Yes	No	0	8	5
147	R:R:F210	R:R:F265	7.5	Yes	Yes	8	8	7
148	R:R:A212	R:R:P213	1.87	No	No	0	5	8
149	R:R:F257	R:R:L214	2.44	No	No	0	9	7
150	R:R:I217	R:R:Y221	3.63	No	Yes	0	8	9
151	R:R:V250	R:R:Y221	5.05	Yes	Yes	0	7	9
152	R:R:L253	R:R:Y221	2.34	No	Yes	0	8	9
153	R:R:L222	R:R:V226	2.98	No	No	0	3	3
154	R:R:V225	R:R:V246	1.6	No	No	9	5	7
155	R:R:V225	R:R:V250	1.6	No	Yes	9	5	7
156	R:R:E243	R:R:R229	19.77	No	No	0	6	4
157	R:R:A231	R:R:G232	1.95	No	No	0	5	4
158	R:R:R240	R:R:R241	4.26	No	No	0	3	4
159	R:R:R241	R:R:S242	2.64	No	No	0	4	5
160	R:R:E243	R:R:R244	4.65	No	No	0	6	4
161	R:R:V246	R:R:V250	1.6	No	Yes	9	7	7
162	R:R:V250	R:R:V254	1.6	Yes	No	0	7	7
163	R:R:V252	R:R:V256	1.6	No	No	0	6	6
164	R:R:C260	R:R:V256	1.71	No	No	0	8	6
165	R:R:A258	R:R:G259	1.95	No	No	0	5	5
166	R:R:C260	R:R:N296	6.3	No	No	0	8	9
167	R:R:F265	R:R:W261	4.01	Yes	Yes	8	7	8
168	R:R:S293	R:R:W261	3.71	No	Yes	0	7	8
169	R:R:N296	R:R:W261	7.91	No	Yes	0	9	8
170	R:R:L262	R:R:P263	3.28	No	No	0	5	9
171	R:R:F264	R:R:N268	8.46	No	No	0	7	5
172	R:R:F264	R:R:V289	2.62	No	No	0	7	7
173	L:L:K5	R:R:F264	3.72	Yes	No	0	0	7
174	R:R:T266	R:R:V270	1.59	No	No	0	6	5
175	R:R:V267	R:R:V289	8.02	No	No	0	5	7
176	R:R:L276	R:R:N271	2.75	No	No	0	1	4
177	R:R:N271	R:R:Y286	5.81	No	No	0	4	4
178	R:R:A273	R:R:V274	1.7	No	No	0	5	4
179	R:R:L276	R:R:P277	1.64	No	No	0	1	3
180	R:R:E279	R:R:P280	9.43	No	No	0	2	1
181	R:R:A281	R:R:E279	4.53	No	No	0	1	2
182	L:L:?1	R:R:S282	6.36	Yes	No	0	0	5
183	L:L:T8	R:R:A283	1.68	Yes	No	0	0	4
184	L:L:C2	R:R:Y286	6.72	Yes	No	3	0	4
185	L:L:T8	R:R:Y286	6.24	Yes	No	3	0	4
186	L:L:T6	R:R:V290	3.17	No	No	0	0	5
187	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
188	R:R:N300	R:R:P301	1.63	Yes	No	0	9	9
189	R:R:F306	R:R:F311	3.22	No	No	6	7	8
190	R:R:F306	R:R:F315	6.43	No	No	0	7	6
191	R:R:F311	R:R:S308	3.96	No	No	0	8	8
192	L:L:?1	L:L:C2	5.38	Yes	Yes	3	0	0
193	L:L:?1	L:L:T8	8.74	Yes	Yes	3	0	0
194	L:L:C2	L:L:C7	5.46	Yes	No	3	0	0
195	L:L:C2	L:L:T8	6.76	Yes	Yes	3	0	0
196	L:L:?4	L:L:F3	5.8	No	Yes	0	0	0
197	L:L:?4	L:L:K5	10.07	No	Yes	0	0	0
198	L:L:C7	L:L:T8	1.69	No	Yes	3	0	0
199	R:R:I62	R:R:V84	1.54	No	No	0	7	6
200	R:R:I224	R:R:V228	1.54	No	No	0	8	8
201	R:R:H143	R:R:P144	1.53	No	No	0	7	7
202	R:R:I217	R:R:T131	1.52	No	No	0	8	7
203	L:L:K5	R:R:V290	1.52	Yes	No	0	0	5
204	R:R:F107	R:R:G108	1.51	Yes	No	0	7	8
205	R:R:F287	R:R:G284	1.51	Yes	No	0	3	1
206	R:R:L88	R:R:V84	1.49	No	No	0	7	6
207	R:R:L276	R:R:V274	1.49	No	No	0	1	4
208	R:R:L285	R:R:V289	1.49	No	No	0	5	7
209	R:R:L303	R:R:V302	1.49	No	No	0	8	7
210	R:R:D86	R:R:S126	1.47	Yes	No	0	9	9
211	R:R:G305	R:R:Y304	1.45	No	No	0	7	9
212	R:R:F95	R:R:P94	1.44	No	No	0	6	8
213	R:R:P153	R:R:R152	1.44	No	No	0	2	6
214	R:R:L174	R:R:M116	1.41	No	No	0	3	5
215	R:R:L208	R:R:M170	1.41	No	No	0	4	4
216	R:R:M71	R:R:N76	1.4	No	Yes	0	7	8
217	R:R:H143	R:R:S146	1.39	No	No	0	7	4
218	L:L:K5	R:R:D119	1.38	Yes	No	0	0	6
219	R:R:L253	R:R:L303	1.38	No	No	0	8	8
220	R:R:L80	R:R:N81	1.37	No	Yes	0	6	9
221	R:R:D309	R:R:N310	1.35	No	No	0	5	6
222	R:R:F128	R:R:S167	1.32	No	Yes	0	5	7
223	R:R:F287	R:R:V43	1.31	Yes	No	0	3	6
224	R:R:F306	R:R:V61	1.31	No	No	6	7	9
225	R:R:F311	R:R:V61	1.31	No	No	6	8	9
226	R:R:R229	R:R:V225	1.31	No	No	0	4	5
227	R:R:D309	R:R:Q313	1.31	No	No	0	5	4
228	R:R:R229	R:R:T247	1.29	No	No	0	4	6
229	R:R:V50	R:R:Y294	1.26	No	No	0	7	7
230	R:R:F265	R:R:I269	1.26	Yes	No	0	7	6
231	R:R:F288	R:R:I291	1.26	No	No	0	4	5
232	R:R:V194	R:R:W190	1.23	No	Yes	0	2	6
233	R:R:I291	R:R:Y47	1.21	No	Yes	0	5	7
234	R:R:L114	R:R:R113	1.21	No	Yes	0	5	6
235	R:R:I203	R:R:Y204	1.21	No	Yes	0	5	3
236	R:R:D309	R:R:R312	1.19	No	No	0	5	8
237	R:R:L93	R:R:Y47	1.17	No	Yes	0	7	7
238	L:L:?1	R:R:Q278	1.13	Yes	No	0	0	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y47	4.175	4	0	7
2	R:R:N58	4.1	4	0	9
3	R:R:N76	2.9	4	0	8
4	R:R:I77	4.7475	4	4	6
5	R:R:Y78	5.07667	6	4	7
6	R:R:N81	2.9825	4	0	9
7	R:R:D86	3.36	5	0	9
8	R:R:Y89	6.295	4	0	6
9	R:R:W105	8.345	6	1	8
10	R:R:F107	5.015	4	1	7
11	R:R:R113	5.1425	4	1	6
12	R:R:Y138	7.075	4	0	8
13	R:R:S167	2.595	4	0	7
14	R:R:V180	2.742	5	1	5
15	R:R:W190	3.77429	7	2	6
16	R:R:W197	5.72	4	2	3
17	R:R:Y204	4.62	4	7	3
18	R:R:F210	4.0225	4	8	8
19	R:R:Y221	3.5275	4	0	9
20	R:R:V250	2.4625	4	9	7
21	R:R:W261	4.91	4	8	8
22	R:R:F265	3.885	4	8	7
23	R:R:F287	3.895	4	0	3
24	R:R:N300	4.8325	4	0	9
25	L:L:?1	5.4025	4	3	0
26	L:L:C2	6.08	4	3	0
27	L:L:F3	4.735	4	0	0
28	L:L:K5	4.1725	4	0	0
29	L:L:T8	5.022	5	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C51	R:R:M90	32.9466	3.24	No	No	0	6	6
2	R:R:C51	R:R:L93	24.8799	6.35	No	No	0	6	7
3	R:R:L93	R:R:Y47	16.36	1.17	No	Yes	0	7	7
4	R:R:M90	R:R:V50	34.5056	3.04	No	No	0	6	7
5	R:R:D86	R:R:S297	94.2173	5.89	Yes	No	0	9	9
6	R:R:S297	R:R:Y89	94.6705	2.54	No	Yes	0	9	6
7	R:R:Y294	R:R:Y89	37.5691	8.94	No	Yes	0	7	6
8	R:R:V50	R:R:Y294	36.0464	1.26	No	No	0	7	7
9	R:R:D86	R:R:N300	86.7216	2.69	Yes	Yes	0	9	9
10	R:R:I77	R:R:M71	11.4656	4.37	Yes	No	0	6	7
11	R:R:I77	R:R:Y78	14.7829	8.46	Yes	Yes	4	6	7
12	R:R:M133	R:R:Y78	33.1279	4.79	No	Yes	0	8	7
13	R:R:M133	R:R:Y304	70.9327	3.59	No	No	0	8	9
14	R:R:L130	R:R:Y304	73.0898	2.34	No	No	0	9	9
15	R:R:L130	R:R:N300	76.0899	2.75	No	Yes	0	9	9
16	R:R:D86	R:R:L82	11.1393	2.71	Yes	No	0	9	9
17	R:R:F124	R:R:S167	14.7104	2.64	No	Yes	0	6	7
18	R:R:F124	R:R:Q123	19.9311	8.2	No	No	0	6	7
19	R:R:Q123	R:R:Y89	100	7.89	No	Yes	0	7	6
20	L:L:T6	R:R:V290	79.7607	3.17	No	No	0	0	5
21	L:L:K5	R:R:V290	80.5493	1.52	Yes	No	0	0	5
22	L:L:?4	L:L:K5	86.5313	10.07	No	Yes	0	0	0
23	L:L:?4	R:R:Q123	97.8156	2.11	No	No	0	0	7
24	R:R:Q99	R:R:W105	45.6539	6.57	No	Yes	0	4	8
25	R:R:N100	R:R:Q99	77.2229	10.56	No	No	0	4	4
26	L:L:T6	R:R:N100	78.1292	4.39	No	No	0	0	4
27	R:R:Q99	R:R:T185	42.7082	2.83	No	No	0	4	4
28	R:R:C112	R:R:W105	15.5896	9.14	No	Yes	1	9	8
29	R:R:C186	R:R:W105	15.5896	19.59	No	Yes	1	9	8
30	R:R:C112	R:R:V180	13.9128	3.42	No	Yes	1	9	5
31	R:R:C186	R:R:V180	13.9128	1.71	No	Yes	1	9	5
32	R:R:R113	R:R:V180	14.1666	2.62	Yes	Yes	1	6	5
33	R:R:I217	R:R:Y221	26.9102	3.63	No	Yes	0	8	9
34	R:R:R137	R:R:Y221	44.666	3.09	No	Yes	0	9	9
35	R:R:M133	R:R:R137	46.1434	2.48	No	No	0	8	9
36	R:R:I217	R:R:S134	18.3903	3.1	No	No	0	8	9
37	R:R:C220	R:R:S134	12.943	5.16	No	No	0	8	9
38	R:R:C220	R:R:Y138	11.1484	2.69	No	Yes	0	8	8
39	L:L:F3	R:R:F201	12.7345	5.36	Yes	No	0	0	5
40	L:L:?4	L:L:F3	37.2066	5.8	No	Yes	0	0	0
41	L:L:F3	R:R:W190	19.7589	4.01	Yes	Yes	0	0	6
42	R:R:N187	R:R:T185	38.7927	4.39	No	No	0	5	4
43	L:L:C7	R:R:N187	37.2609	4.72	No	No	0	0	5
44	R:R:N296	R:R:W261	16.6319	7.91	No	Yes	0	9	8
45	R:R:N296	R:R:N300	23.5566	12.26	No	Yes	0	9	9
46	R:R:V250	R:R:Y221	14.3207	5.05	Yes	Yes	0	7	9
47	R:R:L276	R:R:N271	14.1666	2.75	No	No	0	1	4
48	R:R:N271	R:R:Y286	17.5202	5.81	No	No	0	4	4
49	L:L:C2	R:R:Y286	10.4051	6.72	Yes	No	3	0	4
50	L:L:C2	L:L:C7	17.0851	5.46	Yes	No	3	0	0
51	L:L:T8	R:R:Y286	10.3145	6.24	Yes	No	3	0	4
52	L:L:C7	L:L:T8	18.6622	1.69	No	Yes	3	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q123	R:R:Y89	7.89	0	No	Yes	7	6	1	2
L:L:T6	R:R:L96	4.42	0	No	No	0	6	0	1
R:R:N100	R:R:Q99	10.56	0	No	No	4	4	1	2
R:R:Q99	R:R:T185	2.83	0	No	No	4	4	2	2
L:L:T6	R:R:N100	4.39	0	No	No	0	4	0	1
R:R:D119	R:R:G120	3.35	0	No	No	6	5	1	2
R:R:F124	R:R:Q123	8.2	0	No	No	6	7	2	1
L:L:?4	R:R:Q123	2.11	0	No	No	0	7	0	1
R:R:F177	R:R:W190	6.01	2	No	Yes	4	6	2	1
R:R:F177	R:R:P191	7.22	2	No	No	4	4	2	2
R:R:F177	R:R:W197	7.02	2	No	Yes	4	3	2	2
R:R:A178	R:R:W190	5.19	2	No	Yes	5	6	2	1
R:R:A178	R:R:P191	3.74	2	No	No	5	4	2	2
R:R:N187	R:R:T185	4.39	0	No	No	5	4	1	2
L:L:C7	R:R:N187	4.72	3	No	No	0	5	0	1
R:R:A188	R:R:W190	2.59	0	No	Yes	3	6	2	1
R:R:P191	R:R:W190	2.7	2	No	Yes	4	6	2	1
R:R:W190	R:R:W197	4.69	2	Yes	Yes	6	3	1	2
L:L:F3	R:R:W190	4.01	0	Yes	Yes	0	6	0	1
R:R:F201	R:R:Y204	8.25	7	No	Yes	5	3	1	2
R:R:F201	R:R:T205	5.19	7	No	No	5	4	1	2
L:L:F3	R:R:F201	5.36	0	Yes	No	0	5	0	1
R:R:I202	R:R:L272	2.85	0	No	No	5	4	1	2
L:L:F3	R:R:I202	3.77	0	Yes	No	0	5	0	1
R:R:T205	R:R:Y204	6.24	7	No	Yes	4	3	2	2
R:R:F264	R:R:N268	8.46	0	No	No	7	5	1	2
R:R:F264	R:R:V289	2.62	0	No	No	7	7	1	2
L:L:K5	R:R:F264	3.72	0	Yes	No	0	7	0	1
R:R:N271	R:R:Y286	5.81	0	No	No	4	4	2	1
L:L:?1	R:R:S282	6.36	3	Yes	No	0	5	0	1
L:L:T8	R:R:A283	1.68	3	Yes	No	0	4	0	1
L:L:C2	R:R:Y286	6.72	3	Yes	No	0	4	0	1
L:L:T8	R:R:Y286	6.24	3	Yes	No	0	4	0	1
L:L:T6	R:R:V290	3.17	0	No	No	0	5	0	1
L:L:K5	R:R:V290	1.52	0	Yes	No	0	5	0	1
L:L:K5	R:R:D119	1.38	0	Yes	No	0	6	0	1
R:R:V194	R:R:W190	1.23	0	No	Yes	2	6	2	1
L:L:?1	R:R:Q278	1.13	3	Yes	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X8N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.56
Number of Linked Nodes	231
Number of Links	238
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	9
Number of Nodes involved in Communities	37
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	21695
Length Of Smallest Path	3
Average Path Length	13.8344
Length of Longest Path	32
Minimum Path Strength	1.19
Average Path Strength	4.55618
Maximum Path Strength	14.66
Minimum Path Correlation	0.7
Average Path Correlation	0.924253
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	45.5386
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.7796
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DPN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35346
Sequence	>8X8N_nogp_Chain_R V P V L Y L L V C A A G L G G N T L V I Y V V L R F A K M K T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A S F W P F G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H P L S S A R W R R P R V A K L A S A A A W V L S L C M S L P L L V F A D V Q E G G T C N A S W P E P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V L V L V F A G C W L P F F T V N I V N L A V A L P Q E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F R Q S F Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZBE	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	Gi1/β1/γ1	3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBE (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-	Gi1/β1/γ1	3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-		3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8X8L	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8L (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-		2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8ZBJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.94	2025-04-30	To be published
	8ZBJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-		2.94	2025-04-30	To be published

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