psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C2	L:L:C7	7.28	No	No	0	0	0
2	L:L:C2	R:R:N271	9.45	No	No	0	0	4
3	L:L:?4	L:L:F3	5.8	Yes	Yes	1	0	0
4	L:L:F3	R:R:N187	6.04	Yes	Yes	1	0	5
5	L:L:F3	R:R:S189	3.96	Yes	No	1	0	1
6	L:L:F3	R:R:G198	4.52	Yes	No	0	0	4
7	L:L:F3	R:R:I202	3.77	Yes	No	0	0	5
8	L:L:?4	L:L:K5	32.46	Yes	No	1	0	0
9	L:L:?4	R:R:M116	7.85	Yes	No	1	0	5
10	L:L:?4	R:R:F124	4.83	Yes	Yes	1	0	6
11	L:L:?4	R:R:N187	19.62	Yes	Yes	1	0	5
12	L:L:?4	R:R:T205	4.68	Yes	Yes	1	0	4
13	L:L:?4	R:R:F264	4.83	Yes	Yes	1	0	7
14	L:L:K5	R:R:Q123	5.42	No	Yes	1	0	7
15	L:L:K5	R:R:F264	9.93	No	Yes	1	0	7
16	L:L:T6	R:R:Q99	14.17	No	No	0	0	4
17	L:L:T6	R:R:N187	4.39	No	Yes	0	0	5
18	R:R:P44	R:R:V43	3.53	No	Yes	0	5	6
19	R:R:N100	R:R:V43	10.35	No	Yes	3	4	6
20	R:R:F287	R:R:V43	10.49	Yes	Yes	3	3	6
21	R:R:F288	R:R:L46	9.74	No	No	0	4	5
22	R:R:I291	R:R:L46	14.27	No	No	0	5	5
23	R:R:L48	R:R:Y47	7.03	No	No	0	4	7
24	R:R:A97	R:R:Y47	4	No	No	0	6	7
25	R:R:L93	R:R:V50	7.45	No	No	0	7	7
26	R:R:I291	R:R:V50	9.22	No	No	0	5	7
27	R:R:C51	R:R:L93	9.52	No	No	0	6	7
28	R:R:C298	R:R:G54	3.92	No	No	0	8	8
29	R:R:L55	R:R:M90	5.65	No	Yes	0	6	6
30	R:R:D86	R:R:N58	18.85	No	No	0	9	9
31	R:R:N58	R:R:V87	4.43	No	No	0	9	7
32	R:R:N58	R:R:P301	17.92	No	No	0	9	9
33	R:R:L60	R:R:Y63	11.72	No	No	0	6	4
34	R:R:I62	R:R:V87	4.61	No	No	0	7	7
35	R:R:V64	R:R:Y63	11.36	Yes	No	0	7	4
36	R:R:F68	R:R:V64	3.93	No	Yes	0	5	7
37	R:R:N76	R:R:V65	8.87	No	No	0	8	7
38	R:R:F68	R:R:K317	6.2	No	No	0	5	4
39	R:R:M71	R:R:T73	7.53	No	No	0	7	7
40	R:R:M71	R:R:N76	12.62	No	No	0	7	8
41	R:R:F311	R:R:M71	3.73	Yes	No	0	8	7
42	R:R:K72	R:R:P153	6.69	No	No	0	6	2
43	R:R:T73	R:R:T75	4.71	No	Yes	0	7	7
44	R:R:V74	R:R:Y78	8.83	Yes	Yes	2	6	7
45	R:R:D136	R:R:V74	8.76	Yes	Yes	2	8	6
46	R:R:R151	R:R:V74	3.92	Yes	Yes	2	6	6
47	R:R:A156	R:R:V74	5.09	No	Yes	2	7	6
48	R:R:M133	R:R:T75	7.53	Yes	Yes	2	8	7
49	R:R:D136	R:R:T75	7.23	Yes	Yes	2	8	7
50	R:R:R137	R:R:T75	5.17	Yes	Yes	2	9	7
51	R:R:V132	R:R:Y78	10.09	No	Yes	0	7	7
52	R:R:M133	R:R:Y78	7.18	Yes	Yes	2	8	7
53	R:R:D136	R:R:Y78	10.34	Yes	Yes	2	8	7
54	R:R:A156	R:R:Y78	5.34	No	Yes	2	7	7
55	R:R:A159	R:R:Y78	4	No	Yes	0	5	7
56	R:R:I79	R:R:M133	4.37	No	Yes	0	8	8
57	R:R:I79	R:R:Y304	3.63	No	Yes	0	8	9
58	R:R:F311	R:R:I79	5.02	Yes	No	0	8	8
59	R:R:L80	R:R:V84	4.47	No	No	0	6	6
60	R:R:C129	R:R:N81	4.72	No	No	0	8	9
61	R:R:N81	R:R:S160	10.43	No	No	0	9	8
62	R:R:D86	R:R:M90	4.16	No	Yes	0	9	6
63	R:R:D86	R:R:S297	10.31	No	No	0	9	9
64	R:R:L88	R:R:N122	12.36	No	No	0	7	8
65	R:R:D119	R:R:Y89	9.2	Yes	Yes	0	6	6
66	R:R:N122	R:R:Y89	12.79	No	Yes	0	8	6
67	R:R:Q123	R:R:Y89	11.27	Yes	Yes	0	7	6
68	R:R:Y294	R:R:Y89	6.95	Yes	Yes	0	7	6
69	R:R:F95	R:R:L91	3.65	No	No	0	6	4
70	R:R:D119	R:R:L91	5.43	Yes	No	0	6	4
71	R:R:D119	R:R:G92	5.03	Yes	No	0	6	6
72	R:R:G92	R:R:Y294	4.35	No	Yes	0	6	7
73	R:R:L93	R:R:Y294	12.89	No	Yes	0	7	7
74	R:R:F95	R:R:W105	16.04	No	Yes	0	6	8
75	R:R:F95	R:R:V115	11.8	No	No	0	6	5
76	R:R:F287	R:R:L96	7.31	Yes	No	0	3	6
77	R:R:L96	R:R:V290	4.47	No	No	0	6	5
78	R:R:L96	R:R:Y294	5.86	No	Yes	0	6	7
79	R:R:T98	R:R:W105	4.85	No	Yes	0	4	8
80	R:R:F287	R:R:Q99	14.05	Yes	No	0	3	4
81	R:R:F287	R:R:N100	3.62	Yes	No	3	3	4
82	R:R:F104	R:R:L111	3.65	No	Yes	0	4	5
83	R:R:F104	R:R:Q181	8.2	No	No	0	4	1
84	R:R:P106	R:R:W105	24.32	No	Yes	0	3	8
85	R:R:G108	R:R:W105	4.22	No	Yes	0	8	8
86	R:R:V110	R:R:W105	11.03	No	Yes	0	2	8
87	R:R:L111	R:R:W105	30.75	Yes	Yes	0	5	8
88	R:R:F107	R:R:V110	7.87	No	No	0	7	2
89	R:R:G108	R:R:P109	4.06	No	No	0	8	3
90	R:R:L111	R:R:V115	4.47	Yes	No	0	5	5
91	R:R:C186	R:R:L111	7.94	No	Yes	0	9	5
92	R:R:C112	R:R:C186	7.28	No	No	0	9	9
93	R:R:L114	R:R:T117	8.84	No	Yes	4	5	6
94	R:R:L114	R:R:L175	9.69	No	No	4	5	5
95	R:R:L174	R:R:M116	7.07	Yes	No	1	3	5
96	R:R:M116	R:R:N187	5.61	No	Yes	1	5	5
97	R:R:L175	R:R:T117	11.79	No	Yes	4	5	6
98	R:R:S167	R:R:V121	8.08	No	No	0	7	5
99	R:R:L168	R:R:V121	4.47	No	No	0	4	5
100	R:R:S171	R:R:V121	6.46	No	No	0	7	5
101	R:R:Q123	R:R:W261	10.95	Yes	Yes	1	7	8
102	R:R:F265	R:R:Q123	7.03	Yes	Yes	1	7	7
103	R:R:F124	R:R:S167	3.96	Yes	No	0	6	7
104	R:R:F124	R:R:M170	11.2	Yes	Yes	1	6	4
105	R:R:F124	R:R:T205	5.19	Yes	Yes	1	6	4
106	R:R:T125	R:R:W164	15.77	No	No	0	7	9
107	R:R:S167	R:R:T125	6.4	No	No	0	7	7
108	R:R:P213	R:R:V127	3.53	Yes	No	0	8	8
109	R:R:V127	R:R:W261	3.68	No	Yes	0	8	8
110	R:R:A163	R:R:F128	6.93	No	No	0	6	5
111	R:R:F128	R:R:L166	8.53	No	No	0	5	4
112	R:R:F257	R:R:L130	14.61	Yes	Yes	2	9	9
113	R:R:L130	R:R:N300	6.87	Yes	No	2	9	9
114	R:R:L130	R:R:Y304	4.69	Yes	Yes	2	9	9
115	R:R:I217	R:R:T131	12.16	No	No	0	8	7
116	R:R:D136	R:R:M133	6.93	Yes	Yes	2	8	8
117	R:R:M133	R:R:R137	13.65	Yes	Yes	2	8	9
118	R:R:S134	R:R:Y221	3.82	No	Yes	0	9	9
119	R:R:D136	R:R:R151	8.34	Yes	Yes	2	8	6
120	R:R:R137	R:R:Y221	12.35	Yes	Yes	2	9	9
121	R:R:M249	R:R:R137	3.72	No	Yes	0	8	9
122	R:R:R137	R:R:Y304	4.12	Yes	Yes	2	9	9
123	R:R:V142	R:R:Y138	12.62	No	No	5	7	8
124	R:R:H143	R:R:Y138	4.36	Yes	No	5	7	8
125	R:R:L139	R:R:R151	8.5	No	Yes	0	5	6
126	R:R:A140	R:R:R151	4.15	No	Yes	0	8	6
127	R:R:I224	R:R:V141	6.14	No	No	0	8	8
128	R:R:H143	R:R:V142	9.69	Yes	No	5	7	7
129	R:R:H143	R:R:L145	6.43	Yes	No	0	7	5
130	R:R:P144	R:R:S147	3.56	No	No	0	7	5
131	R:R:A148	R:R:R152	4.15	No	No	0	5	6
132	R:R:V155	R:R:W150	19.61	No	No	0	4	4
133	R:R:S160	R:R:W164	3.71	No	No	0	8	9
134	R:R:M170	R:R:Y204	7.18	Yes	No	1	4	3
135	R:R:M170	R:R:T205	4.52	Yes	Yes	1	4	4
136	R:R:L208	R:R:M170	11.31	No	Yes	1	4	4
137	R:R:L174	R:R:S189	4.5	Yes	No	1	3	1
138	R:R:F201	R:R:L174	12.18	Yes	Yes	1	5	3
139	R:R:F177	R:R:V176	5.24	Yes	No	0	4	4
140	R:R:F177	R:R:P193	5.78	Yes	No	6	4	4
141	R:R:F177	R:R:W197	4.01	Yes	No	6	4	3
142	R:R:D179	R:R:E192	9.09	No	No	0	4	3
143	R:R:P191	R:R:V180	8.84	No	No	0	4	5
144	R:R:F201	R:R:S189	13.21	Yes	No	1	5	1
145	R:R:G198	R:R:W190	4.22	No	No	0	4	6
146	R:R:P193	R:R:W197	12.16	No	No	6	4	3
147	R:R:G195	R:R:V194	3.68	No	No	0	3	2
148	R:R:F201	R:R:I202	5.02	Yes	No	0	5	5
149	R:R:F201	R:R:T205	7.78	Yes	Yes	1	5	4
150	R:R:I202	R:R:L272	4.28	No	Yes	0	5	4
151	R:R:L208	R:R:Y204	11.72	No	No	1	4	3
152	R:R:F211	R:R:V207	5.24	No	No	0	5	5
153	R:R:G209	R:R:P213	4.06	No	Yes	0	5	8
154	R:R:F210	R:R:L215	10.96	No	No	0	8	3
155	R:R:F210	R:R:L262	6.09	No	No	0	8	5
156	R:R:A212	R:R:P213	3.74	No	Yes	0	5	8
157	R:R:F257	R:R:L214	14.61	Yes	No	0	9	7
158	R:R:L219	R:R:L222	4.15	No	No	0	4	3
159	R:R:Y221	R:R:Y304	4.96	Yes	Yes	2	9	9
160	R:R:E243	R:R:R229	8.14	No	No	0	6	4
161	R:R:R239	R:R:S242	3.95	No	No	0	3	5
162	R:R:E243	R:R:R240	9.3	No	No	0	6	3
163	R:R:L307	R:R:M249	18.38	Yes	No	0	6	8
164	R:R:L303	R:R:V252	7.45	Yes	No	0	8	6
165	R:R:L303	R:R:V253	4.47	Yes	No	0	8	8
166	R:R:V253	R:R:Y304	5.05	No	Yes	0	8	9
167	R:R:N296	R:R:V256	4.43	Yes	No	0	9	6
168	R:R:F257	R:R:N296	18.12	Yes	Yes	0	9	9
169	R:R:F257	R:R:N300	12.08	Yes	No	2	9	9
170	R:R:C260	R:R:N296	4.72	No	Yes	0	8	9
171	R:R:F265	R:R:W261	14.03	Yes	Yes	1	7	8
172	R:R:N296	R:R:W261	4.52	Yes	Yes	0	9	8
173	R:R:F264	R:R:F265	7.5	Yes	Yes	1	7	7
174	R:R:F264	R:R:N268	4.83	Yes	No	0	7	5
175	R:R:F264	R:R:V290	3.93	Yes	No	0	7	5
176	R:R:F264	R:R:S293	7.93	Yes	No	0	7	7
177	R:R:V267	R:R:Y286	11.36	No	No	0	5	4
178	R:R:N268	R:R:N271	8.17	No	No	0	5	4
179	R:R:N268	R:R:Y286	8.14	No	No	0	5	4
180	R:R:E279	R:R:P280	14.15	No	No	0	2	1
181	R:R:F288	R:R:L285	3.65	No	No	0	4	5
182	R:R:I291	R:R:L292	4.28	No	No	0	5	7
183	R:R:F306	R:R:V302	9.18	Yes	No	0	7	7
184	R:R:F306	R:R:L303	8.53	Yes	Yes	7	7	8
185	R:R:L303	R:R:L307	5.54	Yes	Yes	7	8	6
186	R:R:F311	R:R:G305	6.02	Yes	No	0	8	7
187	R:R:F306	R:R:L307	3.65	Yes	Yes	7	7	6
188	R:R:F306	R:R:R312	4.28	Yes	No	0	7	8
189	R:R:F311	R:R:S308	13.21	Yes	No	0	8	8
190	R:R:P213	R:R:T131	3.5	Yes	No	0	8	7
191	R:R:E192	R:R:F177	3.5	No	Yes	0	3	4
192	R:R:A69	R:R:S314	3.42	No	No	0	5	5
193	R:R:C186	R:R:V180	3.42	No	No	0	9	5
194	R:R:A188	R:R:V180	3.39	No	No	0	3	5
195	R:R:A85	R:R:T125	3.36	No	No	0	8	7
196	R:R:L174	R:R:P173	3.28	Yes	No	0	3	7
197	R:R:C220	R:R:I217	3.27	No	No	0	8	8
198	R:R:A83	R:R:I62	3.25	No	No	0	8	7
199	R:R:A156	R:R:I77	3.25	No	No	0	7	6
200	R:R:C51	R:R:M90	3.24	No	Yes	0	6	6
201	R:R:V267	R:R:V289	3.21	No	No	0	5	7
202	R:R:C129	R:R:L82	3.17	No	No	0	8	9
203	R:R:C218	R:R:L130	3.17	No	Yes	0	4	9
204	R:R:C218	R:R:L214	3.17	No	No	0	4	7
205	R:R:A258	R:R:L262	3.15	No	No	0	5	5
206	R:R:A275	R:R:N271	3.13	No	No	0	4	4
207	R:R:I217	R:R:V135	3.07	No	No	0	8	6
208	R:R:I224	R:R:V142	3.07	No	No	0	8	7
209	R:R:I224	R:R:V225	3.07	No	Yes	0	8	5
210	R:R:A281	R:R:E279	3.02	No	No	0	1	2
211	R:R:F210	R:R:W261	3.01	No	Yes	0	8	8
212	R:R:L215	R:R:V216	2.98	No	No	0	3	7
213	R:R:L223	R:R:V226	2.98	No	No	0	4	3
214	R:R:L276	R:R:V274	2.98	No	No	0	1	4
215	R:R:F177	R:R:P173	2.89	Yes	No	0	4	7
216	R:R:Q278	R:R:S282	2.89	No	No	0	1	5
217	R:R:I62	R:R:L80	2.85	No	No	0	7	6
218	R:R:I203	R:R:L272	2.85	No	Yes	0	5	4
219	R:R:K70	R:R:L66	2.82	No	No	0	5	3
220	R:R:K157	R:R:N81	2.8	No	No	0	3	9
221	R:R:A206	R:R:F265	2.77	No	Yes	0	4	7
222	R:R:L251	R:R:L255	2.77	No	No	0	4	4
223	R:R:R151	R:R:S147	2.64	Yes	No	0	6	5
224	R:R:F315	R:R:V64	2.62	No	Yes	0	6	7
225	R:R:F128	R:R:T131	2.59	No	No	0	5	7
226	R:R:K70	R:R:R67	2.48	No	No	0	5	4
227	R:R:F288	R:R:L42	2.44	No	No	0	4	6
228	R:R:F211	R:R:L215	2.44	No	No	0	5	3
229	R:R:L114	R:R:R113	2.43	No	No	0	5	6
230	R:R:L158	R:R:R154	2.43	No	No	0	3	4
231	R:R:L139	R:R:W150	2.28	No	No	0	5	4
232	R:R:G56	R:R:G57	2.11	No	No	0	4	8
233	R:R:A53	R:R:G54	1.95	No	No	0	5	8
234	R:R:C51	R:R:P94	1.88	No	No	0	6	8
235	R:R:P301	R:R:V61	1.77	No	No	0	9	9
236	R:R:P263	R:R:V289	1.77	No	No	0	9	7
237	R:R:G54	R:R:M90	1.75	No	Yes	0	8	6
238	R:R:G57	R:R:L60	1.71	No	No	0	8	6
239	R:R:A85	R:R:S126	1.71	No	No	0	8	9
240	R:R:A97	R:R:V43	1.7	No	Yes	0	6	6
241	R:R:A295	R:R:V50	1.7	No	No	0	5	7
242	R:R:A299	R:R:V256	1.7	No	No	0	6	6
243	R:R:A178	R:R:T117	1.68	No	Yes	0	5	6
244	R:R:D119	R:R:G120	1.68	Yes	No	0	6	5
245	R:R:L172	R:R:P173	1.64	No	No	0	5	7
246	R:R:L276	R:R:P277	1.64	No	No	0	1	3
247	R:R:V64	R:R:V65	1.6	Yes	No	0	7	7
248	R:R:S103	R:R:T98	1.6	No	No	0	4	4
249	R:R:S171	R:R:T117	1.6	No	Yes	0	7	6
250	R:R:V141	R:R:V228	1.6	No	No	0	8	8
251	R:R:V225	R:R:V246	1.6	Yes	No	8	5	7
252	R:R:V225	R:R:V250	1.6	Yes	No	8	5	7
253	R:R:V246	R:R:V250	1.6	No	No	8	7	7
254	R:R:T59	R:R:V87	1.59	No	No	0	4	7
255	R:R:C169	R:R:L172	1.59	No	No	0	3	5
256	R:R:A52	R:R:L48	1.58	No	No	0	5	4
257	R:R:A199	R:R:L196	1.58	No	No	0	3	1
258	R:R:A199	R:R:L272	1.58	No	Yes	0	3	4
259	R:R:H143	R:R:P144	1.53	Yes	No	0	7	7
260	R:R:F287	R:R:G284	1.51	Yes	No	0	3	1
261	R:R:L166	R:R:V165	1.49	No	No	0	4	5
262	R:R:L276	R:R:V270	1.49	No	No	0	1	5
263	R:R:N310	R:R:S308	1.49	No	No	0	6	8
264	R:R:L118	R:R:T117	1.47	No	Yes	0	5	6
265	R:R:L251	R:R:T247	1.47	No	No	0	4	6
266	R:R:L262	R:R:T266	1.47	No	No	0	5	6
267	R:R:P153	R:R:R152	1.44	No	No	0	2	6
268	R:R:I269	R:R:L272	1.43	No	Yes	0	6	4
269	R:R:G195	R:R:W190	1.41	No	No	0	3	6
270	R:R:F311	R:R:S314	1.32	Yes	No	0	8	5
271	R:R:R149	R:R:V155	1.31	No	No	0	3	4
272	R:R:R229	R:R:V225	1.31	No	Yes	0	4	5
273	R:R:R244	R:R:T247	1.29	No	No	0	4	6
274	R:R:V254	R:R:Y221	1.26	No	Yes	0	7	9
275	R:R:L307	R:R:R248	1.21	Yes	No	0	6	5
276	R:R:F68	R:R:R67	1.07	No	No	0	5	4
277	R:R:R244	R:R:R248	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F3	4.818	5	1	0
2	L:L:?4	11.4386	7	1	0
3	R:R:V43	6.5175	4	3	6
4	R:R:V64	4.8775	4	0	7
5	R:R:V74	6.65	4	2	6
6	R:R:T75	6.16	4	2	7
7	R:R:Y78	7.63	6	2	7
8	R:R:Y89	10.0525	4	0	6
9	R:R:M90	3.7	4	0	6
10	R:R:W105	15.2017	6	0	8
11	R:R:L111	11.7025	4	0	5
12	R:R:T117	5.076	5	4	6
13	R:R:D119	5.335	4	0	6
14	R:R:Q123	8.6675	4	1	7
15	R:R:F124	6.295	4	1	6
16	R:R:L130	7.335	4	2	9
17	R:R:M133	7.932	5	2	8
18	R:R:D136	8.32	5	2	8
19	R:R:R137	7.802	5	2	9
20	R:R:H143	5.5025	4	5	7
21	R:R:R151	5.51	5	2	6
22	R:R:M170	8.5525	4	1	4
23	R:R:L174	6.7575	4	1	3
24	R:R:F177	4.284	5	6	4
25	R:R:N187	8.915	4	1	5
26	R:R:F201	9.5475	4	1	5
27	R:R:T205	5.5425	4	1	4
28	R:R:P213	3.7075	4	0	8
29	R:R:Y221	5.5975	4	2	9
30	R:R:V225	1.895	4	8	5
31	R:R:F257	14.855	4	2	9
32	R:R:W261	7.238	5	1	8
33	R:R:F264	6.49167	6	1	7
34	R:R:F265	7.8325	4	1	7
35	R:R:L272	2.535	4	0	4
36	R:R:F287	7.396	5	3	3
37	R:R:Y294	7.5125	4	0	7
38	R:R:N296	7.9475	4	0	9
39	R:R:L303	6.4975	4	7	8
40	R:R:Y304	4.49	5	2	9
41	R:R:F306	6.41	4	7	7
42	R:R:L307	7.195	4	7	6
43	R:R:F311	5.86	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	R:R:F264	35.3645	4.83	Yes	Yes	1	0	7
2	L:L:?4	L:L:F3	16.5559	5.8	Yes	Yes	1	0	0
3	L:L:?4	R:R:M116	15.5087	7.85	Yes	No	1	0	5
4	L:L:?4	R:R:F124	34.2065	4.83	Yes	Yes	1	0	6
5	L:L:K5	R:R:Q123	39.5406	5.42	No	Yes	1	0	7
6	R:R:F264	R:R:F265	40.3221	7.5	Yes	Yes	1	7	7
7	R:R:F264	R:R:V290	13.389	3.93	Yes	No	0	7	5
8	R:R:L96	R:R:V290	12.9746	4.47	No	No	0	6	5
9	R:R:F287	R:R:L96	14.5311	7.31	Yes	No	0	3	6
10	R:R:L96	R:R:Y294	15.0468	5.86	No	Yes	0	6	7
11	R:R:L93	R:R:Y294	30.5334	12.89	No	Yes	0	7	7
12	R:R:C51	R:R:L93	20.8238	9.52	No	No	0	6	7
13	R:R:C51	R:R:M90	18.5934	3.24	No	Yes	0	6	6
14	R:R:D86	R:R:M90	12.9145	4.16	No	Yes	0	9	6
15	R:R:D86	R:R:N58	10.5986	18.85	No	No	0	9	9
16	R:R:F265	R:R:W261	39.702	14.03	Yes	Yes	1	7	8
17	R:R:N296	R:R:W261	100	4.52	Yes	Yes	0	9	8
18	R:R:F257	R:R:N296	98.7978	18.12	Yes	Yes	0	9	9
19	R:R:F257	R:R:L130	96.5642	14.61	Yes	Yes	2	9	9
20	R:R:L130	R:R:Y304	96.6085	4.69	Yes	Yes	2	9	9
21	R:R:I79	R:R:Y304	39.471	3.63	No	Yes	0	8	9
22	R:R:F311	R:R:I79	17.078	5.02	Yes	No	0	8	8
23	R:R:F311	R:R:M71	11.6268	3.73	Yes	No	0	8	7
24	R:R:M71	R:R:N76	13.0347	12.62	No	No	0	7	8
25	R:R:N76	R:R:V65	12.0697	8.87	No	No	0	8	7
26	R:R:V64	R:R:V65	11.0985	1.6	Yes	No	0	7	7
27	R:R:R137	R:R:Y304	47.2982	4.12	Yes	Yes	2	9	9
28	R:R:R137	R:R:T75	20.517	5.17	Yes	Yes	2	9	7
29	R:R:I79	R:R:M133	23.706	4.37	No	Yes	0	8	8
30	R:R:M133	R:R:Y78	10.0228	7.18	Yes	Yes	2	8	7
31	R:R:M133	R:R:R137	24.073	13.65	Yes	Yes	2	8	9
32	R:R:D136	R:R:M133	36.0953	6.93	Yes	Yes	2	8	8
33	R:R:D136	R:R:T75	19.8526	7.23	Yes	Yes	2	8	7
34	R:R:D136	R:R:R151	50.9301	8.34	Yes	Yes	2	8	6
35	R:R:F124	R:R:S167	29.9323	3.96	Yes	No	0	6	7
36	R:R:S167	R:R:T125	14.4615	6.4	No	No	0	7	7
37	R:R:Q123	R:R:Y89	50.0569	11.27	Yes	Yes	0	7	6
38	R:R:D119	R:R:Y89	26.4205	9.2	Yes	Yes	0	6	6
39	R:R:D119	R:R:L91	27.6607	5.43	Yes	No	0	6	4
40	R:R:F95	R:R:L91	26.6958	3.65	No	No	0	6	4
41	R:R:F95	R:R:W105	16.6224	16.04	No	Yes	0	6	8
42	R:R:C186	R:R:L111	10.6587	7.94	No	Yes	0	9	5
43	R:R:S167	R:R:V121	14.4615	8.08	No	No	0	7	5
44	R:R:S171	R:R:V121	11.2914	6.46	No	No	0	7	5
45	R:R:L174	R:R:M116	14.7399	7.07	Yes	No	1	3	5
46	R:R:V127	R:R:W261	13.5219	3.68	No	Yes	0	8	8
47	R:R:P213	R:R:V127	12.4209	3.53	Yes	No	0	8	8
48	R:R:R151	R:R:S147	37.0159	2.64	Yes	No	0	6	5
49	R:R:P144	R:R:S147	34.5071	3.56	No	No	0	7	5
50	R:R:H143	R:R:P144	31.9919	1.53	Yes	No	0	7	7
51	R:R:H143	R:R:V142	24.3767	9.69	Yes	No	5	7	7
52	R:R:I224	R:R:V142	21.8552	3.07	No	No	0	8	7
53	R:R:L174	R:R:P173	14.2907	3.28	Yes	No	0	3	7
54	R:R:I224	R:R:V225	14.5121	3.07	No	Yes	0	8	5
55	R:R:V253	R:R:Y304	10.3961	5.05	No	Yes	0	8	9
56	L:L:?4	L:L:K5	37.9619	32.46	Yes	No	1	0	0
57	R:R:Y294	R:R:Y89	29.521	6.95	Yes	Yes	0	7	6
58	R:R:Q123	R:R:W261	64.8855	10.95	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:C2	R:R:N271	9.45	0	No	No	0	4	0	1
L:L:F3	R:R:N187	6.04	1	Yes	Yes	0	5	0	1
L:L:F3	R:R:S189	3.96	1	Yes	No	0	1	0	1
L:L:F3	R:R:G198	4.52	1	Yes	No	0	4	0	1
L:L:F3	R:R:I202	3.77	1	Yes	No	0	5	0	1
L:L:?4	R:R:M116	7.85	1	Yes	No	0	5	0	1
L:L:?4	R:R:F124	4.83	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N187	19.62	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:T205	4.68	1	Yes	Yes	0	4	0	1
L:L:?4	R:R:F264	4.83	1	Yes	Yes	0	7	0	1
L:L:K5	R:R:Q123	5.42	1	No	Yes	0	7	0	1
L:L:K5	R:R:F264	9.93	1	No	Yes	0	7	0	1
L:L:T6	R:R:Q99	14.17	0	No	No	0	4	0	1
L:L:T6	R:R:N187	4.39	0	No	Yes	0	5	0	1
R:R:Q123	R:R:Y89	11.27	1	Yes	Yes	7	6	1	2
R:R:F287	R:R:Q99	14.05	3	Yes	No	3	4	2	1
R:R:L174	R:R:M116	7.07	1	Yes	No	3	5	2	1
R:R:M116	R:R:N187	5.61	1	No	Yes	5	5	1	1
R:R:Q123	R:R:W261	10.95	1	Yes	Yes	7	8	1	2
R:R:F265	R:R:Q123	7.03	1	Yes	Yes	7	7	2	1
R:R:F124	R:R:S167	3.96	1	Yes	No	6	7	1	2
R:R:F124	R:R:M170	11.2	1	Yes	Yes	6	4	1	2
R:R:F124	R:R:T205	5.19	1	Yes	Yes	6	4	1	1
R:R:M170	R:R:T205	4.52	1	Yes	Yes	4	4	2	1
R:R:L174	R:R:S189	4.5	1	Yes	No	3	1	2	1
R:R:F201	R:R:L174	12.18	1	Yes	Yes	5	3	2	2
R:R:F201	R:R:S189	13.21	1	Yes	No	5	1	2	1
R:R:G198	R:R:W190	4.22	0	No	No	4	6	1	2
R:R:F201	R:R:I202	5.02	1	Yes	No	5	5	2	1
R:R:F201	R:R:T205	7.78	1	Yes	Yes	5	4	2	1
R:R:I202	R:R:L272	4.28	0	No	Yes	5	4	1	2
R:R:F265	R:R:W261	14.03	1	Yes	Yes	7	8	2	2
R:R:F264	R:R:F265	7.5	1	Yes	Yes	7	7	1	2
R:R:F264	R:R:N268	4.83	1	Yes	No	7	5	1	2
R:R:F264	R:R:V290	3.93	1	Yes	No	7	5	1	2
R:R:F264	R:R:S293	7.93	1	Yes	No	7	7	1	2
R:R:N268	R:R:N271	8.17	0	No	No	5	4	2	1
R:R:A275	R:R:N271	3.13	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZBE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	252
Number of Links	277
Number of Hubs	43
Number of Links mediated by Hubs	151
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	53958
Length Of Smallest Path	3
Average Path Length	14.4312
Length of Longest Path	30
Minimum Path Strength	1.14
Average Path Strength	7.75024
Maximum Path Strength	27.535
Minimum Path Correlation	0.7
Average Path Correlation	0.913124
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	40.6363
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.4559
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • amide binding • amyloid-beta binding • peptide binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • transporter regulator activity • identical protein binding • protein homodimerization activity • protein dimerization activity • catecholamine binding • norepinephrine binding • peptide receptor activity • G protein-coupled peptide receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • multicellular organismal process • response to nutrient levels • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • bone mineralization • animal organ development • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • import into cell • receptor-mediated endocytosis • endocytosis • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • protein-containing complex organization • regulation of catabolic process • positive regulation of autophagosome maturation • positive regulation of catabolic process • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • positive regulation of signaling • cell surface receptor signaling pathway • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • cellular response to amyloid-beta • response to amyloid-beta • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • neuropeptide signaling pathway • regulation of cytokinesis • positive regulation of cell division • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • response to glucocorticoid • cellular response to glucocorticoid stimulus • cellular response to corticosteroid stimulus • cellular response to endogenous stimulus • response to corticosteroid • response to steroid hormone • cellular response to steroid hormone stimulus • cellular response to hormone stimulus • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • receptor complex • intercellular bridge • endosome membrane • endosome • apical part of cell • apical plasma membrane • mitotic spindle • spindle • early endosome
SCOP2	Domain Identifier	• Ras-like P-loop GTPases
SCOP2	Family Identifier	• Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35346
Sequence	>8ZBE_nogp_Chain_R L V P V L Y L L V C A A G L G G N T L V I Y V V L R F A K M K T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A S F W P F G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H P L S S A R W R R P R V A K L A S A A A W V L S L C M S L P L L V F A D V Q C N A S W P E P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R R R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V A L P Q E P A S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F R Q S F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZBE	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	Gi1/β1/γ1	3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZBE (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		3.24	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-	Gi1/β1/γ1	3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8ZCJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Pasireotide	-		3.09	2024-07-10	doi.org/10.1038/s41401-024-01314-8
	8X8L	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8L (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Cortistatin	-		2.7	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8X8N (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Octreotide	-		2.9	2024-06-12	doi.org/10.1073/pnas.2321710121
	8ZBJ	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-	Gi1/β1/γ2	2.94	2025-04-30	To be published
	8ZBJ (No Gprot)	A	Peptide	Somatostatin	SST5	Homo sapiens	Somatostatin-14	-		2.94	2025-04-30	To be published

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