psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A31	7.43	Yes	No	0	0	7
2	L:L:?1	R:R:L78	4.66	Yes	No	0	0	8
3	L:L:?1	R:R:T81	6.96	Yes	No	0	0	7
4	L:L:?1	R:R:V85	12.05	Yes	No	0	0	8
5	L:L:?1	R:R:H89	6.93	Yes	No	1	0	7
6	L:L:?1	R:R:M112	9.53	Yes	No	0	0	8
7	L:L:?1	R:R:G116	4.61	Yes	No	0	0	7
8	L:L:?1	R:R:P179	3.32	Yes	Yes	1	0	8
9	L:L:?1	R:R:S181	5.06	Yes	Yes	1	0	8
10	L:L:?1	R:R:W182	15.35	Yes	Yes	1	0	7
11	L:L:?1	R:R:W258	8.45	Yes	Yes	1	0	8
12	L:L:?1	R:R:L294	8.4	Yes	No	1	0	7
13	L:L:?1	R:R:R295	4.09	Yes	Yes	0	0	8
14	L:L:?1	R:R:T298	6.96	Yes	No	0	0	8
15	L:L:?1	R:R:Q301	8.07	Yes	Yes	1	0	9
16	R:R:C102	R:R:C11	7.28	No	No	0	2	4
17	R:R:F12	R:R:W95	8.02	No	Yes	0	3	6
18	R:R:F12	R:R:H96	31.68	No	No	0	3	2
19	R:R:P14	R:R:R13	5.76	No	No	0	3	4
20	R:R:I17	R:R:R22	3.76	No	No	0	3	1
21	R:R:E20	R:R:T18	7.06	No	No	0	3	8
22	R:R:E21	R:R:T18	8.47	Yes	No	1	2	8
23	R:R:R284	R:R:T18	5.17	Yes	No	1	1	8
24	R:R:L19	R:R:R23	8.5	No	No	0	3	1
25	R:R:E21	R:R:I25	4.1	Yes	No	1	2	3
26	R:R:E21	R:R:Y178	3.37	Yes	Yes	1	2	3
27	R:R:E21	R:R:R284	4.65	Yes	Yes	1	2	1
28	R:R:E21	R:R:K288	8.1	Yes	No	1	2	1
29	R:R:R22	R:R:R23	15.99	No	No	0	1	1
30	R:R:I25	R:R:Y178	3.63	No	Yes	1	3	3
31	R:R:I25	R:R:K288	8.72	No	No	1	3	1
32	R:R:A26	R:R:P179	3.74	No	Yes	0	4	8
33	R:R:F30	R:R:S27	7.93	No	No	0	5	7
34	R:R:H89	R:R:P28	4.58	No	No	0	7	6
35	R:R:F30	R:R:R295	16.03	No	Yes	0	5	8
36	R:R:F34	R:R:W299	17.04	No	No	0	8	4
37	R:R:G38	R:R:I302	7.05	No	No	0	9	9
38	R:R:S41	R:R:W306	8.65	No	No	0	9	8
39	R:R:D74	R:R:N42	5.39	Yes	No	0	9	9
40	R:R:N42	R:R:P305	11.4	No	No	0	9	9
41	R:R:F75	R:R:L43	8.53	No	No	0	7	5
42	R:R:L310	R:R:L44	5.54	Yes	No	0	8	5
43	R:R:A45	R:R:I309	4.87	No	Yes	1	9	9
44	R:R:A45	R:R:L310	4.73	No	Yes	1	9	8
45	R:R:L46	R:R:V71	7.45	No	No	0	7	8
46	R:R:V315	R:R:V48	4.81	No	No	0	7	8
47	R:R:L49	R:R:L67	4.15	No	Yes	1	8	8
48	R:R:Q146	R:R:R53	5.84	No	No	0	5	6
49	R:R:H58	R:R:S57	8.37	No	No	0	5	5
50	R:R:H58	R:R:L64	9	No	No	0	5	7
51	R:R:F66	R:R:S62	5.28	Yes	No	0	7	6
52	R:R:E129	R:R:S62	8.62	No	No	0	9	6
53	R:R:F63	R:R:L67	6.09	Yes	Yes	1	8	8
54	R:R:F63	R:R:M126	3.73	Yes	Yes	1	8	9
55	R:R:F63	R:R:R130	10.69	Yes	No	0	8	9
56	R:R:Q146	R:R:T65	5.67	No	No	0	5	6
57	R:R:A149	R:R:T65	5.03	No	No	0	7	6
58	R:R:T65	R:R:W150	12.13	No	No	0	6	4
59	R:R:A125	R:R:F66	4.16	No	Yes	0	6	7
60	R:R:F66	R:R:M126	3.73	Yes	Yes	0	7	9
61	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
62	R:R:F66	R:R:V153	3.93	Yes	No	0	7	7
63	R:R:L67	R:R:M126	4.24	Yes	Yes	1	8	9
64	R:R:L67	R:R:Y308	3.52	Yes	Yes	1	8	9
65	R:R:I309	R:R:L67	8.56	Yes	Yes	1	9	8
66	R:R:D74	R:R:L70	5.43	Yes	Yes	1	9	9
67	R:R:L70	R:R:P119	3.28	Yes	Yes	1	9	8
68	R:R:D304	R:R:L70	8.14	Yes	Yes	1	9	9
69	R:R:L70	R:R:Y308	4.69	Yes	Yes	1	9	9
70	R:R:S118	R:R:T73	4.8	Yes	No	1	7	9
71	R:R:P119	R:R:T73	3.5	Yes	No	1	8	9
72	R:R:T73	R:R:W157	7.28	No	Yes	1	9	7
73	R:R:D74	R:R:P119	4.83	Yes	Yes	1	9	8
74	R:R:D74	R:R:Q301	10.44	Yes	Yes	1	9	9
75	R:R:D304	R:R:D74	3.99	Yes	Yes	1	9	9
76	R:R:F115	R:R:L76	4.87	Yes	No	0	7	6
77	R:R:F115	R:R:G77	10.54	Yes	No	0	7	8
78	R:R:V111	R:R:V80	4.81	No	No	0	5	6
79	R:R:F115	R:R:V80	3.93	Yes	No	0	7	6
80	R:R:M108	R:R:T81	4.52	No	No	0	6	7
81	R:R:I84	R:R:M108	7.29	No	No	0	5	6
82	R:R:L92	R:R:Q88	10.65	No	No	0	4	6
83	R:R:H89	R:R:S181	5.58	No	Yes	1	7	8
84	R:R:L92	R:R:V98	17.88	No	No	0	4	5
85	R:R:A97	R:R:E94	4.53	No	No	0	4	4
86	R:R:L104	R:R:W95	3.42	No	Yes	0	6	6
87	R:R:C105	R:R:W95	5.22	No	Yes	2	9	6
88	R:R:V176	R:R:W95	8.58	No	Yes	2	4	6
89	R:R:C183	R:R:W95	5.22	Yes	Yes	2	9	6
90	R:R:D99	R:R:G101	3.35	No	No	0	5	3
91	R:R:C102	R:R:R106	4.18	No	No	0	2	5
92	R:R:C105	R:R:C183	7.28	No	Yes	2	9	9
93	R:R:L168	R:R:R106	3.64	No	No	0	5	5
94	R:R:C183	R:R:M108	3.24	Yes	No	0	9	6
95	R:R:G109	R:R:Y174	10.14	No	No	0	8	6
96	R:R:V110	R:R:Y174	5.05	No	No	0	6	6
97	R:R:G164	R:R:I113	3.53	No	No	0	7	7
98	R:R:F200	R:R:I113	6.28	No	No	0	8	7
99	R:R:F114	R:R:F115	9.65	Yes	Yes	0	7	7
100	R:R:F114	R:R:S118	3.96	Yes	Yes	1	7	7
101	R:R:F114	R:R:W157	8.02	Yes	Yes	1	7	7
102	R:R:F114	R:R:L161	3.65	Yes	No	0	7	4
103	R:R:S118	R:R:W157	4.94	Yes	Yes	1	7	7
104	R:R:P119	R:R:Q301	7.9	Yes	Yes	1	8	9
105	R:R:L120	R:R:W258	21.64	No	Yes	0	8	8
106	R:R:L121	R:R:V156	5.96	No	No	0	6	6
107	R:R:L121	R:R:S207	4.5	No	Yes	0	6	7
108	R:R:L122	R:R:V156	7.45	No	No	0	7	6
109	R:R:M126	R:R:Y308	10.78	Yes	Yes	1	9	9
110	R:R:A127	R:R:S211	3.42	No	No	0	9	8
111	R:R:E129	R:R:R140	13.96	No	Yes	0	9	8
112	R:R:Q246	R:R:R130	15.19	No	No	0	8	9
113	R:R:L247	R:R:R130	4.86	Yes	No	0	8	9
114	R:R:L132	R:R:Y131	3.52	No	Yes	0	6	7
115	R:R:T135	R:R:Y131	13.73	No	Yes	0	7	7
116	R:R:L214	R:R:Y131	7.03	Yes	Yes	0	7	7
117	R:R:V217	R:R:Y131	8.83	No	Yes	0	5	7
118	R:R:L132	R:R:R140	8.5	No	Yes	0	6	8
119	R:R:R136	R:R:S139	5.27	No	No	0	5	4
120	R:R:V153	R:R:W150	4.9	No	No	0	7	4
121	R:R:V153	R:R:W157	7.36	No	Yes	0	7	7
122	R:R:F196	R:R:L163	3.65	Yes	Yes	0	7	6
123	R:R:F200	R:R:L163	3.65	No	Yes	0	8	6
124	R:R:F196	R:R:L166	3.65	Yes	No	0	7	8
125	R:R:P167	R:R:Y174	19.47	No	No	0	9	6
126	R:R:F196	R:R:P167	13	Yes	No	0	7	9
127	R:R:R173	R:R:T186	12.94	No	No	0	3	4
128	R:R:E190	R:R:R173	11.63	No	No	3	1	3
129	R:R:D193	R:R:R173	8.34	No	No	3	4	3
130	R:R:T175	R:R:T186	14.13	No	No	0	3	4
131	R:R:C183	R:R:V176	3.42	Yes	No	2	9	4
132	R:R:Q177	R:R:W182	7.67	No	Yes	0	7	7
133	R:R:L290	R:R:Q177	3.99	No	No	0	6	7
134	R:R:P179	R:R:Y178	9.74	Yes	Yes	1	8	3
135	R:R:R284	R:R:Y178	13.38	Yes	Yes	1	1	3
136	R:R:E287	R:R:Y178	7.86	No	Yes	1	3	3
137	R:R:P179	R:R:S181	3.56	Yes	Yes	1	8	8
138	R:R:F184	R:R:W182	7.02	No	Yes	0	8	7
139	R:R:L291	R:R:W182	3.42	No	Yes	0	7	7
140	R:R:L294	R:R:W182	10.25	No	Yes	1	7	7
141	R:R:F184	R:R:L185	14.61	No	Yes	0	8	5
142	R:R:F196	R:R:L185	6.09	Yes	Yes	0	7	5
143	R:R:F200	R:R:L185	3.65	No	Yes	0	8	5
144	R:R:L187	R:R:T268	5.9	No	Yes	0	6	6
145	R:R:D193	R:R:G188	5.03	No	No	0	4	4
146	R:R:G188	R:R:M276	5.24	No	No	0	4	1
147	R:R:A189	R:R:P274	3.74	No	No	0	3	1
148	R:R:D193	R:R:E190	15.59	No	No	3	4	1
149	R:R:V194	R:R:V269	4.81	No	No	0	3	5
150	R:R:L198	R:R:L270	4.15	No	No	0	4	3
151	R:R:L259	R:R:V208	4.47	No	No	0	6	7
152	R:R:L210	R:R:L214	4.15	No	Yes	0	6	7
153	R:R:F212	R:R:T216	3.89	No	No	0	5	5
154	R:R:F212	R:R:M251	8.71	No	No	0	5	8
155	R:R:F212	R:R:S255	5.28	No	No	0	5	5
156	R:R:L247	R:R:N215	5.49	Yes	No	0	8	9
157	R:R:I250	R:R:N215	4.25	No	No	0	8	9
158	R:R:M251	R:R:N215	4.21	No	No	0	8	9
159	R:R:L247	R:R:V219	4.47	Yes	No	0	8	7
160	R:R:L222	R:R:M244	4.24	No	No	0	8	6
161	R:R:C223	R:R:M244	4.86	No	No	0	4	6
162	R:R:E240	R:R:V225	8.56	No	No	0	8	7
163	R:R:R237	R:R:Y226	21.61	Yes	Yes	0	5	6
164	R:R:E240	R:R:Y226	4.49	No	Yes	0	8	6
165	R:R:V241	R:R:Y226	5.05	No	Yes	0	4	6
166	R:R:E230	R:R:Q234	11.47	No	No	0	3	4
167	R:R:R235	R:R:R237	4.26	No	Yes	0	7	5
168	R:R:E240	R:R:R235	4.65	No	No	0	8	7
169	R:R:E242	R:R:R313	5.82	No	No	0	8	6
170	R:R:L247	R:R:M243	7.07	Yes	No	0	8	8
171	R:R:Q246	R:R:R312	24.53	No	Yes	0	8	9
172	R:R:I250	R:R:V307	4.61	No	No	0	8	8
173	R:R:I250	R:R:Y308	13.3	No	Yes	0	8	9
174	R:R:L303	R:R:V253	8.94	No	No	0	7	7
175	R:R:L259	R:R:S255	4.5	No	No	0	6	5
176	R:R:L262	R:R:W258	4.56	No	Yes	0	8	8
177	R:R:A297	R:R:W258	5.19	No	Yes	0	8	8
178	R:R:N300	R:R:W258	10.17	Yes	Yes	1	9	8
179	R:R:Q301	R:R:W258	6.57	Yes	Yes	1	9	8
180	R:R:F264	R:R:T268	7.78	Yes	Yes	0	4	6
181	R:R:E289	R:R:F264	7	No	Yes	0	1	4
182	R:R:F264	R:R:L290	6.09	Yes	No	0	4	6
183	R:R:F264	R:R:Y293	9.28	Yes	No	0	4	7
184	R:R:A275	R:R:R271	5.53	No	No	0	1	3
185	R:R:G280	R:R:M276	3.49	No	No	0	5	1
186	R:R:L282	R:R:M276	8.48	No	No	0	4	1
187	R:R:E287	R:R:L282	5.3	No	No	0	3	4
188	R:R:S283	R:R:T286	7.99	No	No	0	1	2
189	R:R:E287	R:R:R284	3.49	No	Yes	1	3	1
190	R:R:L291	R:R:R295	13.36	No	Yes	0	7	8
191	R:R:I302	R:R:W299	11.74	No	No	0	9	4
192	R:R:N300	R:R:Q301	9.24	Yes	Yes	1	9	9
193	R:R:D304	R:R:N300	12.12	Yes	Yes	1	9	9
194	R:R:D304	R:R:Y308	8.05	Yes	Yes	1	9	9
195	R:R:L310	R:R:W306	14.81	Yes	No	0	8	8
196	R:R:F311	R:R:W306	8.02	No	No	0	7	8
197	R:R:I309	R:R:L310	4.28	Yes	Yes	1	9	8
198	R:R:F311	R:R:R312	4.28	No	Yes	0	7	9
199	R:R:D99	R:R:P100	3.22	No	No	0	5	4
200	L:L:?1	R:R:C35	3.21	Yes	No	0	0	6
201	R:R:F34	R:R:R295	3.21	No	Yes	0	8	8
202	R:R:V253	R:R:V307	3.21	No	No	0	7	8
203	R:R:S283	R:R:T285	3.2	No	No	0	1	1
204	R:R:C68	R:R:L72	3.17	No	No	0	5	5
205	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
206	R:R:C257	R:R:N300	3.15	No	Yes	0	9	9
207	R:R:A297	R:R:L261	3.15	No	No	0	8	7
208	R:R:I309	R:R:V315	3.07	Yes	No	0	9	7
209	R:R:A231	R:R:E230	3.02	No	No	0	3	3
210	R:R:F196	R:R:G197	3.01	Yes	No	0	7	6
211	R:R:L120	R:R:S207	3	No	Yes	0	8	7
212	R:R:L214	R:R:S128	3	Yes	No	0	7	6
213	R:R:L165	R:R:V110	2.98	No	No	0	5	6
214	R:R:L168	R:R:V110	2.98	No	No	0	5	6
215	R:R:A52	R:R:H58	2.93	No	No	0	6	5
216	R:R:Q281	R:R:S277	2.89	No	Yes	0	4	2
217	R:R:P28	R:R:R22	2.88	No	No	0	6	1
218	R:R:P141	R:R:R140	2.88	No	Yes	0	5	8
219	R:R:Q267	R:R:V263	2.87	No	No	0	4	6
220	R:R:E94	R:R:V98	2.85	No	No	0	4	5
221	R:R:I134	R:R:L222	2.85	No	No	0	8	8
222	R:R:I265	R:R:L185	2.85	No	Yes	0	7	5
223	R:R:I265	R:R:L187	2.85	No	No	0	7	6
224	R:R:L222	R:R:M243	2.83	No	No	0	8	8
225	R:R:L248	R:R:M251	2.83	No	No	0	6	8
226	R:R:L39	R:R:L78	2.77	No	No	0	6	8
227	R:R:L319	R:R:L44	2.77	No	No	0	4	5
228	R:R:L46	R:R:L72	2.77	No	No	0	7	5
229	R:R:L117	R:R:L203	2.77	No	No	0	7	5
230	R:R:L163	R:R:L199	2.77	Yes	No	0	6	4
231	R:R:L163	R:R:L203	2.77	Yes	No	0	6	5
232	R:R:A232	R:R:R237	2.77	No	Yes	0	4	5
233	R:R:D99	R:R:L104	2.71	No	No	0	5	6
234	R:R:P28	R:R:W29	2.7	No	No	0	6	3
235	R:R:F63	R:R:S61	2.64	Yes	No	0	8	7
236	R:R:F107	R:R:V80	2.62	No	No	0	6	6
237	R:R:R136	R:R:T135	2.59	No	No	0	5	7
238	R:R:S218	R:R:Y131	2.54	No	Yes	0	9	7
239	R:R:V37	R:R:W299	2.45	No	No	0	6	4
240	R:R:F75	R:R:L39	2.44	No	No	0	7	6
241	R:R:F75	R:R:L76	2.44	No	No	0	7	6
242	R:R:L282	R:R:R13	2.43	No	No	0	4	4
243	R:R:L24	R:R:R23	2.43	No	No	0	1	1
244	R:R:I292	R:R:Y293	2.42	No	No	0	4	7
245	R:R:M244	R:R:Y226	2.39	No	Yes	0	6	6
246	R:R:E242	R:R:R312	2.33	No	Yes	0	8	9
247	R:R:G55	R:R:G56	2.11	No	No	0	3	5
248	R:R:G204	R:R:G205	2.11	No	No	0	7	5
249	R:R:G172	R:R:P167	2.03	No	No	0	8	9
250	R:R:C35	R:R:G82	1.96	No	No	0	6	8
251	R:R:A50	R:R:G51	1.95	No	No	0	3	7
252	R:R:A231	R:R:G228	1.95	No	No	0	3	5
253	R:R:P273	R:R:P274	1.95	No	No	0	1	1
254	R:R:G204	R:R:S207	1.86	No	Yes	0	7	7
255	R:R:G280	R:R:S277	1.86	No	Yes	0	5	2
256	R:R:G192	R:R:V171	1.84	No	No	0	1	4
257	R:R:G180	R:R:V176	1.84	No	No	0	5	4
258	R:R:G249	R:R:V307	1.84	No	No	0	5	8
259	R:R:P278	R:R:S277	1.78	No	Yes	0	7	2
260	R:R:A91	R:R:S87	1.71	No	No	0	4	5
261	R:R:A160	R:R:S118	1.71	No	Yes	0	7	7
262	R:R:A124	R:R:S207	1.71	No	Yes	0	6	7
263	R:R:A124	R:R:S211	1.71	No	No	0	6	8
264	R:R:A266	R:R:S201	1.71	No	No	0	5	7
265	R:R:C257	R:R:V296	1.71	No	No	0	9	7
266	R:R:A279	R:R:S277	1.71	No	Yes	0	1	2
267	R:R:A32	R:R:V86	1.7	No	No	0	5	7
268	R:R:A195	R:R:V171	1.7	No	No	0	5	4
269	R:R:A275	R:R:T268	1.68	No	Yes	0	1	6
270	R:R:L259	R:R:P260	1.64	No	No	0	6	9
271	R:R:D238	R:R:P236	1.61	No	No	0	5	3
272	R:R:V252	R:R:V256	1.6	No	No	0	5	6
273	R:R:C68	R:R:L49	1.59	No	No	0	5	8
274	R:R:T221	R:R:V217	1.59	No	No	0	7	5
275	R:R:A159	R:R:L121	1.58	No	No	0	4	6
276	R:R:A266	R:R:L198	1.58	No	No	0	5	4
277	R:R:T268	R:R:T286	1.57	Yes	No	0	6	2
278	R:R:A254	R:R:N300	1.56	No	Yes	0	8	9
279	R:R:I265	R:R:V269	1.54	No	No	0	7	5
280	R:R:I84	R:R:T83	1.52	No	No	0	5	8
281	R:R:A232	R:R:Q229	1.52	No	No	0	4	4
282	R:R:A314	R:R:E242	1.51	No	No	0	7	8
283	R:R:G133	R:R:R140	1.5	No	Yes	0	8	8
284	R:R:L262	R:R:S201	1.5	No	No	0	8	7
285	R:R:L79	R:R:T83	1.47	No	No	0	6	8
286	R:R:L213	R:R:T216	1.47	No	No	0	4	5
287	R:R:G123	R:R:Y308	1.45	No	Yes	0	8	9
288	R:R:Q88	R:R:S181	1.44	No	Yes	0	6	8
289	R:R:P137	R:R:R136	1.44	No	No	0	8	5
290	R:R:P236	R:R:R235	1.44	No	No	0	3	7
291	R:R:G154	R:R:W157	1.41	No	Yes	0	2	7
292	R:R:L49	R:R:L64	1.38	No	No	1	8	7
293	R:R:A52	R:R:R318	1.38	No	No	0	6	6
294	R:R:A142	R:R:R60	1.38	No	No	0	5	6
295	R:R:L64	R:R:L67	1.38	No	Yes	1	7	8
296	R:R:A231	R:R:R237	1.38	No	Yes	0	3	5
297	R:R:A245	R:R:R312	1.38	No	Yes	0	7	9
298	R:R:L316	R:R:L319	1.38	No	No	0	7	4
299	R:R:R148	R:R:S145	1.32	No	No	0	5	7
300	R:R:F196	R:R:V171	1.31	Yes	No	0	7	4
301	R:R:A32	R:R:W29	1.3	No	No	0	5	3
302	R:R:H227	R:R:Y226	1.09	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.1925	16	1	0
2	R:R:E21	5.738	5	1	2
3	R:R:F63	5.7875	4	1	8
4	R:R:F66	4.718	5	0	7
5	R:R:L67	4.65667	6	1	8
6	R:R:L70	5.385	4	1	9
7	R:R:D74	6.016	5	1	9
8	R:R:W95	6.092	5	2	6
9	R:R:F114	6.32	4	1	7
10	R:R:F115	7.2475	4	0	7
11	R:R:S118	3.8525	4	1	7
12	R:R:P119	4.8775	4	1	8
13	R:R:M126	5.62	4	1	9
14	R:R:Y131	7.13	5	0	7
15	R:R:R140	6.71	4	0	8
16	R:R:W157	5.802	5	1	7
17	R:R:L163	3.21	4	0	6
18	R:R:Y178	7.596	5	1	3
19	R:R:P179	5.09	4	1	8
20	R:R:S181	3.91	4	1	8
21	R:R:W182	8.742	5	1	7
22	R:R:C183	4.79	4	2	9
23	R:R:L185	6.8	4	0	5
24	R:R:F196	5.11833	6	0	7
25	R:R:S207	2.7675	4	0	7
26	R:R:L214	4.3325	4	0	7
27	R:R:Y226	6.926	5	0	6
28	R:R:R237	7.505	4	0	5
29	R:R:L247	5.4725	4	0	8
30	R:R:W258	9.43	6	1	8
31	R:R:F264	7.5375	4	0	4
32	R:R:T268	4.2325	4	0	6
33	R:R:S277	2.06	4	0	2
34	R:R:R284	6.6725	4	1	1
35	R:R:R295	9.1725	4	0	8
36	R:R:N300	7.248	5	1	9
37	R:R:Q301	8.444	5	1	9
38	R:R:D304	8.075	4	1	9
39	R:R:Y308	6.965	6	1	9
40	R:R:I309	5.195	4	1	9
41	R:R:L310	7.34	4	1	8
42	R:R:R312	8.13	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W182	56.1261	15.35	Yes	Yes	1	0	7
2	R:R:F184	R:R:W182	40.5335	7.02	No	Yes	0	8	7
3	R:R:F184	R:R:L185	39.5252	14.61	No	Yes	0	8	5
4	R:R:F196	R:R:L185	25.5781	6.09	Yes	Yes	0	7	5
5	R:R:F196	R:R:P167	13.058	13	Yes	No	0	7	9
6	R:R:P167	R:R:Y174	10.4777	19.47	No	No	0	9	6
7	L:L:?1	R:R:T81	20.3402	6.96	Yes	No	0	0	7
8	R:R:M108	R:R:T81	19.0858	4.52	No	No	0	6	7
9	R:R:C183	R:R:M108	14.2111	3.24	Yes	No	0	9	6
10	L:L:?1	R:R:P179	34.2219	3.32	Yes	Yes	1	0	8
11	R:R:P179	R:R:Y178	32.8067	9.74	Yes	Yes	1	8	3
12	R:R:E287	R:R:Y178	20.624	7.86	No	Yes	1	3	3
13	R:R:E287	R:R:L282	19.5026	5.3	No	No	0	3	4
14	L:L:?1	R:R:H89	12.5042	6.93	Yes	No	1	0	7
15	R:R:H89	R:R:P28	11.9842	4.58	No	No	0	7	6
16	L:L:?1	R:R:R295	11.3987	4.09	Yes	Yes	0	0	8
17	L:L:?1	R:R:W258	32.1894	8.45	Yes	Yes	1	0	8
18	R:R:N300	R:R:W258	27.674	10.17	Yes	Yes	1	9	8
19	R:R:D304	R:R:N300	50.4079	12.12	Yes	Yes	1	9	9
20	R:R:D304	R:R:Y308	73.495	8.05	Yes	Yes	1	9	9
21	R:R:L67	R:R:Y308	41.6589	3.52	Yes	Yes	1	8	9
22	R:R:I309	R:R:L67	16.5592	8.56	Yes	Yes	1	9	8
23	R:R:I309	R:R:L310	10.5889	4.28	Yes	Yes	1	9	8
24	L:L:?1	R:R:Q301	100	8.07	Yes	Yes	1	0	9
25	R:R:N300	R:R:Q301	24.4547	9.24	Yes	Yes	1	9	9
26	R:R:D74	R:R:Q301	47.395	10.44	Yes	Yes	1	9	9
27	R:R:D304	R:R:D74	23.8533	3.99	Yes	Yes	1	9	9
28	R:R:D74	R:R:L70	23.8275	5.43	Yes	Yes	1	9	9
29	R:R:L70	R:R:Y308	47.8872	4.69	Yes	Yes	1	9	9
30	R:R:P119	R:R:Q301	30.4329	7.9	Yes	Yes	1	8	9
31	R:R:L70	R:R:P119	24.5499	3.28	Yes	Yes	1	9	8
32	R:R:M126	R:R:Y308	25.0124	10.78	Yes	Yes	1	9	9
33	R:R:F66	R:R:M126	16.6366	3.73	Yes	Yes	0	7	9
34	R:R:F66	R:R:S62	11.4602	5.28	Yes	No	0	7	6
35	R:R:F63	R:R:L67	12.8516	6.09	Yes	Yes	1	8	8
36	R:R:F63	R:R:M126	14.6121	3.73	Yes	Yes	1	8	9
37	R:R:F63	R:R:R130	22.1523	10.69	Yes	No	0	8	9
38	R:R:Q246	R:R:R130	17.1367	15.19	No	No	0	8	9
39	R:R:I250	R:R:Y308	55.9395	13.3	No	Yes	0	8	9
40	R:R:I250	R:R:N215	48.7545	4.25	No	No	0	8	9
41	R:R:L247	R:R:N215	34.2655	5.49	Yes	No	0	8	9
42	R:R:L282	R:R:M276	15.6878	8.48	No	No	0	4	1
43	R:R:Q177	R:R:W182	14.6518	7.67	No	Yes	0	7	7
44	R:R:L290	R:R:Q177	13.3954	3.99	No	No	0	6	7
45	R:R:F264	R:R:L290	12.278	6.09	Yes	No	0	4	6
46	R:R:M251	R:R:N215	14.3779	4.21	No	No	0	8	9
47	R:R:F212	R:R:M251	11.2101	8.71	No	No	0	5	8
48	R:R:L247	R:R:M243	34.5136	7.07	Yes	No	0	8	8
49	R:R:L222	R:R:M243	33.1957	2.83	No	No	0	8	8
50	R:R:L222	R:R:M244	30.5401	4.24	No	No	0	8	6
51	R:R:M244	R:R:Y226	27.5172	2.39	No	Yes	0	6	6
52	R:R:R237	R:R:Y226	15.3901	21.61	Yes	Yes	0	5	6
53	R:R:Q246	R:R:R312	14.2985	24.53	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A31	7.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:L78	4.66	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	6.96	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	12.05	1	Yes	No	0	8	0	1
L:L:?1	R:R:H89	6.93	1	Yes	No	0	7	0	1
L:L:?1	R:R:M112	9.53	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	4.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:P179	3.32	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S181	5.06	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W182	15.35	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W258	8.45	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L294	8.4	1	Yes	No	0	7	0	1
L:L:?1	R:R:R295	4.09	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T298	6.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q301	8.07	1	Yes	Yes	0	9	0	1
R:R:A26	R:R:P179	3.74	0	No	Yes	4	8	2	1
R:R:H89	R:R:P28	4.58	1	No	No	7	6	1	2
R:R:F30	R:R:R295	16.03	0	No	Yes	5	8	2	1
R:R:D74	R:R:P119	4.83	1	Yes	Yes	9	8	2	2
R:R:D74	R:R:Q301	10.44	1	Yes	Yes	9	9	2	1
R:R:M108	R:R:T81	4.52	0	No	No	6	7	2	1
R:R:H89	R:R:S181	5.58	1	No	Yes	7	8	1	1
R:R:P119	R:R:Q301	7.9	1	Yes	Yes	8	9	2	1
R:R:L120	R:R:W258	21.64	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	7.67	0	No	Yes	7	7	2	1
R:R:P179	R:R:Y178	9.74	1	Yes	Yes	8	3	1	2
R:R:P179	R:R:S181	3.56	1	Yes	Yes	8	8	1	1
R:R:F184	R:R:W182	7.02	0	No	Yes	8	7	2	1
R:R:L291	R:R:W182	3.42	0	No	Yes	7	7	2	1
R:R:L294	R:R:W182	10.25	1	No	Yes	7	7	1	1
R:R:L262	R:R:W258	4.56	0	No	Yes	8	8	2	1
R:R:A297	R:R:W258	5.19	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	10.17	1	Yes	Yes	9	8	2	1
R:R:Q301	R:R:W258	6.57	1	Yes	Yes	9	8	1	1
R:R:L291	R:R:R295	13.36	0	No	Yes	7	8	2	1
R:R:N300	R:R:Q301	9.24	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:C35	3.21	1	Yes	No	0	6	0	1
R:R:F34	R:R:R295	3.21	0	No	Yes	8	8	2	1
R:R:L39	R:R:L78	2.77	0	No	No	6	8	2	1
R:R:C35	R:R:G82	1.96	0	No	No	6	8	1	2
R:R:Q88	R:R:S181	1.44	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.24
Number of Linked Nodes	278
Number of Links	302
Number of Hubs	42
Number of Links mediated by Hubs	157
Number of Communities	3
Number of Nodes involved in Communities	40
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	87702
Length Of Smallest Path	3
Average Path Length	13.0961
Length of Longest Path	27
Minimum Path Strength	1.485
Average Path Strength	7.14519
Maximum Path Strength	19.85
Minimum Path Correlation	0.7
Average Path Correlation	0.918594
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.309
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.8774
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>8XJN_nogp_Chain_R C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R P A V A S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8XJO	A	Lipid	Prostanoid	TP	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	To be published
	8XJO (No Gprot)	A	Lipid	Prostanoid	TP	Homo sapiens	U46619	-		3.11	2024-02-28	To be published
	8XJN	A	Lipid	Prostanoid	TP	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TP	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	10.1038/s41422-021-00591-w
	6TPK	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Retosiban	-	-	3.2	2020-08-05	10.1126/sciadv.abb5419
	6V9S	A	Peptide	Orexin	OX₁	Homo sapiens	GTPL11403	-	-	3.5	2020-07-15	10.1073/pnas.2002704117
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	10.1038/s41589-020-0549-2
	6TP6	A	Peptide	Orexin	OX₁	Homo sapiens	Filorexant	-	-	2.34	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP3	A	Peptide	Orexin	OX₁	Homo sapiens	Nemorexant	-	-	3.04	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6IIV	A	Lipid	Prostanoid	TP	Homo sapiens	Daltroban	-	-	3	2018-12-19	10.1038/s41589-018-0170-9
	6IIU	A	Lipid	Prostanoid	TP	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	10.1038/s41589-018-0170-9
	4PY0	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSATP	-	-	3.1	2014-04-30	10.1038/nature13288
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	10.1021/jm201376w

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