psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A31	4.45	Yes	No	0	0	7
2	L:L:?1	R:R:L78	3.91	Yes	No	0	0	8
3	L:L:?1	R:R:T81	10.4	Yes	No	0	0	7
4	L:L:?1	R:R:V85	9.46	Yes	No	0	0	8
5	L:L:?1	R:R:H89	7.26	Yes	No	0	0	7
6	L:L:?1	R:R:M112	4.99	Yes	No	0	0	8
7	L:L:?1	R:R:W182	8.04	Yes	Yes	1	0	7
8	L:L:?1	R:R:W258	4.02	Yes	Yes	1	0	8
9	L:L:?1	R:R:T298	17.68	Yes	No	0	0	8
10	L:L:?1	R:R:Q301	8.45	Yes	Yes	1	0	9
11	R:R:C102	R:R:C11	7.28	No	No	0	2	4
12	R:R:R13	R:R:T175	12.94	Yes	No	1	4	3
13	R:R:Q177	R:R:R13	5.84	No	Yes	1	7	4
14	R:R:R13	R:R:T186	3.88	Yes	No	1	4	4
15	R:R:P14	R:R:Q281	9.47	No	No	0	3	4
16	R:R:R284	R:R:T15	3.88	No	No	2	1	4
17	R:R:E287	R:R:T15	4.23	Yes	No	2	3	4
18	R:R:I17	R:R:R22	3.76	No	No	0	3	1
19	R:R:I17	R:R:Y178	6.04	No	Yes	0	3	3
20	R:R:E21	R:R:T18	7.06	No	No	0	2	8
21	R:R:E21	R:R:I25	5.47	No	No	0	2	3
22	R:R:E21	R:R:Y178	6.73	No	Yes	0	2	3
23	R:R:A26	R:R:R22	4.15	No	No	0	4	1
24	R:R:L24	R:R:R23	3.64	No	No	0	1	1
25	R:R:I25	R:R:K288	5.82	No	No	0	3	1
26	R:R:A26	R:R:P179	3.74	No	No	0	4	8
27	R:R:P28	R:R:S27	5.34	No	No	0	6	7
28	R:R:S27	R:R:W29	4.94	No	No	0	7	3
29	R:R:H89	R:R:P28	9.15	No	No	0	7	6
30	R:R:F30	R:R:F34	6.43	No	No	0	5	8
31	R:R:F30	R:R:R295	12.83	No	No	0	5	8
32	R:R:F34	R:R:S33	3.96	No	No	0	8	4
33	R:R:F34	R:R:W299	14.03	No	No	0	8	4
34	R:R:C35	R:R:G82	3.92	No	No	0	6	8
35	R:R:G38	R:R:I302	5.29	No	No	0	9	9
36	R:R:F75	R:R:L39	3.65	No	No	0	7	6
37	R:R:L39	R:R:L79	4.15	No	No	0	6	6
38	R:R:P305	R:R:S41	5.34	No	No	0	9	9
39	R:R:S41	R:R:W306	11.12	No	No	0	9	8
40	R:R:D74	R:R:N42	5.39	Yes	No	0	9	9
41	R:R:F75	R:R:N42	4.83	No	No	0	7	9
42	R:R:N42	R:R:P305	6.52	No	No	0	9	9
43	R:R:F75	R:R:L43	8.53	No	No	0	7	5
44	R:R:L46	R:R:V71	4.47	No	No	0	7	8
45	R:R:V315	R:R:V48	4.81	No	No	3	7	8
46	R:R:L49	R:R:L67	4.15	No	No	0	8	8
47	R:R:C68	R:R:L49	6.35	No	No	0	5	8
48	R:R:L64	R:R:S61	6.01	No	Yes	0	7	7
49	R:R:Q146	R:R:S61	4.33	No	Yes	0	5	7
50	R:R:E129	R:R:S62	10.06	No	No	0	9	6
51	R:R:F63	R:R:M126	6.22	No	No	0	8	9
52	R:R:Q146	R:R:T65	11.34	No	No	4	5	6
53	R:R:A149	R:R:T65	5.03	No	No	0	7	6
54	R:R:T65	R:R:W150	14.55	No	No	4	6	4
55	R:R:F66	R:R:L122	3.65	Yes	No	0	7	7
56	R:R:A125	R:R:F66	4.16	No	Yes	0	6	7
57	R:R:E129	R:R:F66	11.66	No	Yes	0	9	7
58	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
59	R:R:F66	R:R:V153	3.93	Yes	Yes	0	7	7
60	R:R:L67	R:R:Y308	4.69	No	Yes	0	8	9
61	R:R:I309	R:R:L67	8.56	No	No	0	9	8
62	R:R:D74	R:R:L70	8.14	Yes	No	1	9	9
63	R:R:L122	R:R:L70	8.3	No	No	0	7	9
64	R:R:D304	R:R:L70	9.5	No	No	1	9	9
65	R:R:F115	R:R:T73	3.89	Yes	No	0	7	9
66	R:R:T73	R:R:W157	8.49	No	Yes	0	9	7
67	R:R:D74	R:R:Q301	7.83	Yes	Yes	1	9	9
68	R:R:D304	R:R:D74	5.32	No	Yes	1	9	9
69	R:R:F115	R:R:G77	10.54	Yes	No	0	7	8
70	R:R:F93	R:R:I84	3.77	No	No	0	3	5
71	R:R:S181	R:R:V85	4.85	Yes	No	0	8	8
72	R:R:F93	R:R:S87	7.93	No	No	0	3	5
73	R:R:Q88	R:R:S181	4.33	No	Yes	0	6	8
74	R:R:H89	R:R:S181	5.58	No	Yes	0	7	8
75	R:R:F93	R:R:L92	4.87	No	No	0	3	4
76	R:R:A97	R:R:E94	4.53	No	No	0	4	4
77	R:R:L104	R:R:W95	6.83	No	No	0	6	6
78	R:R:C105	R:R:W95	5.22	No	No	0	9	6
79	R:R:V176	R:R:W95	11.03	No	No	0	4	6
80	R:R:D99	R:R:V98	5.84	Yes	No	0	5	5
81	R:R:D99	R:R:R103	4.76	Yes	No	0	5	2
82	R:R:D99	R:R:L104	6.79	Yes	No	0	5	6
83	R:R:G101	R:R:R103	4.5	No	No	0	3	2
84	R:R:C105	R:R:C183	7.28	No	No	0	9	9
85	R:R:L168	R:R:R106	3.64	No	No	0	5	5
86	R:R:F107	R:R:V111	3.93	No	No	0	6	5
87	R:R:G109	R:R:Y174	10.14	No	Yes	0	8	6
88	R:R:F115	R:R:V111	5.24	Yes	No	0	7	5
89	R:R:F184	R:R:M112	6.22	Yes	No	0	8	8
90	R:R:I113	R:R:Y174	6.04	Yes	Yes	0	7	6
91	R:R:F184	R:R:I113	3.77	Yes	Yes	0	8	7
92	R:R:F200	R:R:I113	3.77	No	Yes	0	8	7
93	R:R:F114	R:R:F115	10.72	Yes	Yes	0	7	7
94	R:R:F114	R:R:S118	7.93	Yes	No	5	7	7
95	R:R:F114	R:R:W157	7.02	Yes	Yes	5	7	7
96	R:R:L117	R:R:L163	5.54	No	No	0	7	6
97	R:R:F200	R:R:L117	7.31	No	No	0	8	7
98	R:R:S118	R:R:W157	4.94	No	Yes	5	7	7
99	R:R:P119	R:R:Q301	6.32	No	Yes	0	8	9
100	R:R:L120	R:R:W258	13.67	No	Yes	0	8	8
101	R:R:M126	R:R:Y308	9.58	No	Yes	0	9	9
102	R:R:A127	R:R:N215	4.69	No	Yes	0	9	9
103	R:R:N215	R:R:R130	4.82	Yes	Yes	1	9	9
104	R:R:Q246	R:R:R130	4.67	No	Yes	0	8	9
105	R:R:L247	R:R:R130	6.07	No	Yes	1	8	9
106	R:R:I250	R:R:R130	3.76	Yes	Yes	1	8	9
107	R:R:R130	R:R:Y308	9.26	Yes	Yes	1	9	9
108	R:R:T135	R:R:Y131	16.23	No	Yes	0	7	7
109	R:R:L214	R:R:Y131	5.86	Yes	Yes	0	7	7
110	R:R:V217	R:R:Y131	5.05	No	Yes	0	5	7
111	R:R:S218	R:R:Y131	3.82	No	Yes	0	9	7
112	R:R:L132	R:R:R136	4.86	No	Yes	0	6	5
113	R:R:I134	R:R:L222	4.28	No	No	0	8	8
114	R:R:R136	R:R:T135	3.88	Yes	No	0	5	7
115	R:R:T135	R:R:T221	6.28	No	No	0	7	7
116	R:R:R140	R:R:S139	5.27	No	No	0	8	4
117	R:R:Q146	R:R:W150	6.57	No	No	4	5	4
118	R:R:V153	R:R:W150	3.68	Yes	No	0	7	4
119	R:R:V153	R:R:W157	7.36	Yes	Yes	0	7	7
120	R:R:L161	R:R:L165	8.3	No	No	0	4	5
121	R:R:L163	R:R:L199	4.15	No	No	0	6	4
122	R:R:L163	R:R:L203	4.15	No	No	0	6	5
123	R:R:L166	R:R:V171	4.47	No	Yes	0	8	4
124	R:R:G172	R:R:P167	4.06	No	No	6	8	9
125	R:R:P167	R:R:Y174	15.3	No	Yes	0	9	6
126	R:R:F196	R:R:P167	8.67	Yes	No	6	7	9
127	R:R:G172	R:R:V171	3.68	No	Yes	0	8	4
128	R:R:G192	R:R:V171	3.68	No	Yes	0	1	4
129	R:R:F196	R:R:G172	4.52	Yes	No	6	7	8
130	R:R:R173	R:R:T186	10.35	No	No	0	3	4
131	R:R:D193	R:R:R173	11.91	No	No	0	4	3
132	R:R:T175	R:R:T186	7.85	No	No	1	3	4
133	R:R:Q177	R:R:W182	9.86	No	Yes	1	7	7
134	R:R:L290	R:R:Q177	3.99	No	No	1	6	7
135	R:R:P179	R:R:Y178	12.52	No	Yes	0	8	3
136	R:R:R284	R:R:Y178	9.26	No	Yes	2	1	3
137	R:R:E287	R:R:Y178	14.59	Yes	Yes	2	3	3
138	R:R:P179	R:R:S181	3.56	No	Yes	0	8	8
139	R:R:F184	R:R:W182	6.01	Yes	Yes	0	8	7
140	R:R:L290	R:R:W182	5.69	No	Yes	1	6	7
141	R:R:L294	R:R:W182	9.11	No	Yes	0	7	7
142	R:R:F184	R:R:L185	9.74	Yes	No	0	8	5
143	R:R:F196	R:R:L185	6.09	Yes	No	0	7	5
144	R:R:L187	R:R:T268	7.37	No	No	0	6	6
145	R:R:D193	R:R:G188	5.03	No	No	0	4	4
146	R:R:G188	R:R:M276	5.24	No	No	0	4	1
147	R:R:G192	R:R:S191	3.71	No	No	0	1	2
148	R:R:V194	R:R:V269	4.81	No	No	0	3	5
149	R:R:L198	R:R:L270	5.54	No	No	0	4	3
150	R:R:F200	R:R:I265	3.77	No	No	0	8	7
151	R:R:I265	R:R:S201	4.64	No	No	0	7	7
152	R:R:L259	R:R:V208	4.47	No	No	0	6	7
153	R:R:F212	R:R:T216	6.49	No	No	1	5	5
154	R:R:F212	R:R:M251	6.22	No	Yes	1	5	8
155	R:R:F212	R:R:S255	3.96	No	No	0	5	5
156	R:R:L247	R:R:N215	4.12	No	Yes	1	8	9
157	R:R:I250	R:R:N215	4.25	Yes	Yes	1	8	9
158	R:R:M251	R:R:N215	5.61	Yes	Yes	1	8	9
159	R:R:M251	R:R:T216	4.52	Yes	No	1	8	5
160	R:R:L247	R:R:V219	4.47	No	No	0	8	7
161	R:R:L222	R:R:M244	4.24	No	No	0	8	6
162	R:R:C223	R:R:M244	4.86	No	No	0	4	6
163	R:R:E240	R:R:V225	7.13	No	No	0	8	7
164	R:R:H227	R:R:Y226	7.62	No	No	0	5	6
165	R:R:R237	R:R:Y226	15.43	No	No	0	5	6
166	R:R:E230	R:R:R237	13.96	No	No	0	3	5
167	R:R:A232	R:R:Q234	6.06	No	No	0	4	4
168	R:R:E240	R:R:R235	4.65	No	No	0	8	7
169	R:R:E240	R:R:R237	5.82	No	No	0	8	5
170	R:R:D238	R:R:S239	7.36	No	No	0	5	6
171	R:R:E242	R:R:R312	6.98	No	No	0	8	9
172	R:R:E242	R:R:R313	8.14	No	No	0	8	6
173	R:R:Q246	R:R:R312	21.03	No	No	0	8	9
174	R:R:L248	R:R:M251	4.24	No	Yes	0	6	8
175	R:R:I250	R:R:V307	6.14	Yes	No	0	8	8
176	R:R:I250	R:R:Y308	14.51	Yes	Yes	1	8	9
177	R:R:C257	R:R:N300	6.3	No	No	0	9	9
178	R:R:L261	R:R:W258	4.56	No	Yes	0	7	8
179	R:R:A297	R:R:W258	5.19	No	Yes	0	8	8
180	R:R:N300	R:R:W258	9.04	No	Yes	1	9	8
181	R:R:Q301	R:R:W258	4.38	Yes	Yes	1	9	8
182	R:R:L261	R:R:L294	5.54	No	No	0	7	7
183	R:R:Q267	R:R:V263	5.73	No	No	0	4	6
184	R:R:F264	R:R:T268	7.78	Yes	No	0	4	6
185	R:R:E289	R:R:F264	7	No	Yes	0	1	4
186	R:R:F264	R:R:L290	6.09	Yes	No	0	4	6
187	R:R:F264	R:R:Y293	9.28	Yes	No	0	4	7
188	R:R:L270	R:R:V269	4.47	No	No	0	3	5
189	R:R:A275	R:R:R271	5.53	No	No	0	1	3
190	R:R:P278	R:R:S277	3.56	No	No	0	7	2
191	R:R:E287	R:R:L282	7.95	Yes	No	0	3	4
192	R:R:S283	R:R:T286	4.8	No	No	0	1	2
193	R:R:E287	R:R:R284	8.14	Yes	No	2	3	1
194	R:R:L291	R:R:R295	17.01	No	No	0	7	8
195	R:R:I302	R:R:W299	14.09	No	No	0	9	4
196	R:R:N300	R:R:Q301	7.92	No	Yes	1	9	9
197	R:R:D304	R:R:Y308	9.2	No	Yes	1	9	9
198	R:R:L310	R:R:W306	12.53	No	No	0	8	8
199	R:R:F311	R:R:W306	6.01	No	No	0	7	8
200	R:R:R312	R:R:V315	3.92	No	No	0	9	7
201	R:R:G164	R:R:I113	3.53	No	Yes	0	7	7
202	R:R:Q320	R:R:R317	3.5	No	No	0	3	5
203	R:R:A266	R:R:S201	3.42	No	No	0	5	7
204	R:R:G204	R:R:L262	3.42	No	No	0	7	8
205	R:R:L262	R:R:W258	3.42	No	Yes	0	8	8
206	R:R:L303	R:R:W299	3.42	No	No	0	7	4
207	R:R:N272	R:R:P273	3.26	No	No	0	1	1
208	R:R:C105	R:R:M108	3.24	No	No	0	9	6
209	R:R:V111	R:R:V80	3.21	No	No	0	5	6
210	R:R:S283	R:R:T285	3.2	No	No	0	1	1
211	R:R:C35	R:R:L39	3.17	No	No	0	6	6
212	R:R:P321	R:R:Q320	3.16	No	No	0	4	3
213	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
214	R:R:I134	R:R:S218	3.1	No	No	0	8	9
215	R:R:G133	R:R:R60	3	No	No	0	8	6
216	R:R:L120	R:R:S207	3	No	No	0	8	7
217	R:R:L121	R:R:S207	3	No	No	0	6	7
218	R:R:L259	R:R:S255	3	No	No	0	6	5
219	R:R:L319	R:R:V48	2.98	No	No	3	4	8
220	R:R:L49	R:R:V71	2.98	No	No	0	8	8
221	R:R:L165	R:R:V110	2.98	No	No	0	5	6
222	R:R:L121	R:R:V156	2.98	No	No	0	6	6
223	R:R:L303	R:R:V253	2.98	No	No	0	7	7
224	R:R:L319	R:R:V315	2.98	No	No	3	4	7
225	R:R:C223	R:R:H227	2.95	No	No	0	4	5
226	R:R:I84	R:R:M108	2.92	No	No	0	5	6
227	R:R:I134	R:R:M243	2.92	No	No	0	8	8
228	R:R:I25	R:R:L291	2.85	No	No	0	3	7
229	R:R:E289	R:R:T285	2.82	No	No	0	1	1
230	R:R:G116	R:R:W258	2.81	No	Yes	0	7	8
231	R:R:P260	R:R:Y293	2.78	No	No	0	9	7
232	R:R:L310	R:R:L44	2.77	No	No	0	8	5
233	R:R:L72	R:R:L76	2.77	No	No	0	5	6
234	R:R:A160	R:R:F114	2.77	No	Yes	0	7	7
235	R:R:R60	R:R:T59	2.59	No	No	0	6	7
236	R:R:V110	R:R:Y174	2.52	No	Yes	0	6	6
237	R:R:F115	R:R:L76	2.44	Yes	No	0	7	6
238	R:R:G55	R:R:G56	2.11	No	No	0	3	5
239	R:R:G204	R:R:G205	2.11	No	No	0	7	5
240	R:R:C68	R:R:G69	1.96	No	No	0	5	7
241	R:R:C102	R:R:G101	1.96	No	No	0	2	3
242	R:R:A195	R:R:G192	1.95	No	No	0	5	1
243	R:R:P273	R:R:P274	1.95	No	No	0	1	1
244	R:R:C11	R:R:P10	1.88	No	No	0	4	5
245	R:R:A45	R:R:P305	1.87	No	No	0	9	9
246	R:R:A189	R:R:P274	1.87	No	No	0	3	1
247	R:R:G38	R:R:V37	1.84	No	No	0	9	6
248	R:R:G154	R:R:V153	1.84	No	Yes	0	2	7
249	R:R:G170	R:R:V171	1.84	No	Yes	0	7	4
250	R:R:G209	R:R:V208	1.84	No	No	0	3	7
251	R:R:G249	R:R:V252	1.84	No	No	0	5	5
252	R:R:G249	R:R:V307	1.84	No	No	0	5	8
253	R:R:G109	R:R:M108	1.75	No	No	0	8	6
254	R:R:G123	R:R:M126	1.75	No	No	0	8	9
255	R:R:A124	R:R:S211	1.71	No	No	0	6	8
256	R:R:A127	R:R:S211	1.71	No	No	0	9	8
257	R:R:G133	R:R:L132	1.71	No	No	0	8	6
258	R:R:C257	R:R:V256	1.71	No	No	0	9	6
259	R:R:A31	R:R:V86	1.7	No	No	0	7	7
260	R:R:A32	R:R:V86	1.7	No	No	0	5	7
261	R:R:A275	R:R:T268	1.68	No	No	0	1	6
262	R:R:G51	R:R:Q54	1.64	No	No	0	7	5
263	R:R:G228	R:R:Q229	1.64	No	No	0	5	4
264	R:R:S57	R:R:S61	1.63	No	Yes	0	5	7
265	R:R:D99	R:R:P100	1.61	Yes	No	0	5	4
266	R:R:A189	R:R:M276	1.61	No	No	0	3	1
267	R:R:I84	R:R:T83	1.52	No	No	0	5	8
268	R:R:F196	R:R:G197	1.51	Yes	No	0	7	6
269	R:R:L214	R:R:S128	1.5	Yes	No	0	7	6
270	R:R:L168	R:R:V110	1.49	No	No	0	5	6
271	R:R:P14	R:R:R13	1.44	No	Yes	0	3	4
272	R:R:P137	R:R:R136	1.44	No	Yes	0	8	5
273	R:R:P236	R:R:R235	1.44	No	No	0	3	7
274	R:R:Q281	R:R:S277	1.44	No	No	0	4	2
275	R:R:L199	R:R:M202	1.41	No	No	0	4	4
276	R:R:L203	R:R:M202	1.41	No	No	0	5	4
277	R:R:L206	R:R:M202	1.41	No	No	0	3	4
278	R:R:H58	R:R:S61	1.39	No	Yes	0	5	7
279	R:R:L210	R:R:L214	1.38	No	Yes	0	6	7
280	R:R:R136	R:R:S139	1.32	Yes	No	0	5	4
281	R:R:F12	R:R:V176	1.31	No	No	0	3	4
282	R:R:D193	R:R:E190	1.3	No	No	0	4	1
283	R:R:D238	R:R:E242	1.3	No	No	0	5	8
284	R:R:V296	R:R:Y293	1.26	No	No	0	7	7
285	R:R:Q234	R:R:R235	1.17	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.866	10	1	0
2	R:R:R13	6.025	4	1	4
3	R:R:S61	3.34	4	0	7
4	R:R:F66	5.978	5	0	7
5	R:R:D74	6.67	4	1	9
6	R:R:D99	4.75	4	0	5
7	R:R:I113	4.2775	4	0	7
8	R:R:F114	7.11	4	5	7
9	R:R:F115	6.566	5	0	7
10	R:R:R130	5.716	5	1	9
11	R:R:Y131	7.74	4	0	7
12	R:R:R136	2.875	4	0	5
13	R:R:V153	4.2025	4	0	7
14	R:R:W157	6.9525	4	5	7
15	R:R:V171	3.4175	4	0	4
16	R:R:Y174	8.5	4	0	6
17	R:R:Y178	9.828	5	2	3
18	R:R:S181	4.58	4	0	8
19	R:R:W182	7.742	5	1	7
20	R:R:F184	6.435	4	0	8
21	R:R:F196	5.1975	4	6	7
22	R:R:L214	2.9725	4	0	7
23	R:R:N215	4.698	5	1	9
24	R:R:I250	7.165	4	1	8
25	R:R:M251	5.1475	4	1	8
26	R:R:W258	5.88625	8	1	8
27	R:R:F264	7.5375	4	0	4
28	R:R:E287	8.7275	4	2	3
29	R:R:Q301	6.98	5	1	9
30	R:R:Y308	9.448	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M112	37.2311	4.99	Yes	No	0	0	8
2	R:R:F184	R:R:M112	36.6851	6.22	Yes	No	0	8	8
3	R:R:F184	R:R:I113	60.9708	3.77	Yes	Yes	0	8	7
4	R:R:I113	R:R:Y174	42.0089	6.04	Yes	Yes	0	7	6
5	R:R:G109	R:R:Y174	32.2251	10.14	No	Yes	0	8	6
6	R:R:G109	R:R:M108	30.7448	1.75	No	No	0	8	6
7	R:R:C105	R:R:M108	21.7487	3.24	No	No	0	9	6
8	R:R:C105	R:R:W95	18.7065	5.22	No	No	0	9	6
9	R:R:L104	R:R:W95	14.1026	6.83	No	No	0	6	6
10	R:R:D99	R:R:L104	12.557	6.79	Yes	No	0	5	6
11	L:L:?1	R:R:W182	58.0183	8.04	Yes	Yes	1	0	7
12	R:R:F184	R:R:W182	41.3625	6.01	Yes	Yes	0	8	7
13	R:R:Q177	R:R:W182	14.1841	9.86	No	Yes	1	7	7
14	R:R:Q177	R:R:R13	13.9532	5.84	No	Yes	1	7	4
15	L:L:?1	R:R:V85	25.0978	9.46	Yes	No	0	0	8
16	R:R:S181	R:R:V85	24.3182	4.85	Yes	No	0	8	8
17	R:R:P179	R:R:S181	45.339	3.56	No	Yes	0	8	8
18	R:R:P179	R:R:Y178	39.988	12.52	No	Yes	0	8	3
19	L:L:?1	R:R:H89	27.8031	7.26	Yes	No	0	0	7
20	R:R:H89	R:R:S181	24.5382	5.58	No	Yes	0	7	8
21	R:R:E21	R:R:Y178	27.5098	6.73	No	Yes	0	2	3
22	R:R:E21	R:R:I25	23.9923	5.47	No	No	0	2	3
23	R:R:I25	R:R:L291	20.339	2.85	No	No	0	3	7
24	R:R:L291	R:R:R295	18.6196	17.01	No	No	0	7	8
25	R:R:F30	R:R:R295	16.7916	12.83	No	No	0	5	8
26	R:R:F30	R:R:F34	14.9473	6.43	No	No	0	5	8
27	R:R:F34	R:R:W299	11.2424	14.03	No	No	0	8	4
28	L:L:?1	R:R:Q301	95.1842	8.45	Yes	Yes	1	0	9
29	R:R:D74	R:R:Q301	100	7.83	Yes	Yes	1	9	9
30	R:R:D74	R:R:N42	14.2574	5.39	Yes	No	0	9	9
31	R:R:D304	R:R:D74	73.6392	5.32	No	Yes	1	9	9
32	R:R:D304	R:R:Y308	84.3438	9.2	No	Yes	1	9	9
33	R:R:R130	R:R:Y308	42.6228	9.26	Yes	Yes	1	9	9
34	R:R:D74	R:R:L70	23.3431	8.14	Yes	No	1	9	9
35	R:R:L122	R:R:L70	33.624	8.3	No	No	0	7	9
36	R:R:F66	R:R:L122	32.7548	3.65	Yes	No	0	7	7
37	R:R:F66	R:R:V153	28.3545	3.93	Yes	Yes	0	7	7
38	R:R:V153	R:R:W157	19.0922	7.36	Yes	Yes	0	7	7
39	R:R:F200	R:R:I113	18.7391	3.77	No	Yes	0	8	7
40	R:R:F200	R:R:L117	12.5788	7.31	No	No	0	8	7
41	R:R:L117	R:R:L163	11.0251	5.54	No	No	0	7	6
42	R:R:N215	R:R:R130	34.5502	4.82	Yes	Yes	1	9	9
43	R:R:A127	R:R:N215	55.044	4.69	No	Yes	0	9	9
44	R:R:I250	R:R:Y308	36.5004	14.51	Yes	Yes	1	8	9
45	R:R:I250	R:R:N215	33.8711	4.25	Yes	Yes	1	8	9
46	R:R:A127	R:R:L214	50.4156	3.15	No	Yes	0	9	7
47	R:R:L214	R:R:Y131	45.7383	5.86	Yes	Yes	0	7	7
48	R:R:T135	R:R:Y131	16.8188	16.23	No	Yes	0	7	7
49	R:R:S218	R:R:Y131	26.6243	3.82	No	Yes	0	9	7
50	R:R:R136	R:R:T135	13.5403	3.88	Yes	No	0	5	7
51	R:R:I134	R:R:S218	24.9837	3.1	No	No	0	8	9
52	R:R:I134	R:R:L222	21.7487	4.28	No	No	0	8	8
53	R:R:F184	R:R:L185	16.1098	9.74	Yes	No	0	8	5
54	R:R:F196	R:R:L185	14.6512	6.09	Yes	No	0	7	5
55	R:R:F196	R:R:G172	10.1885	4.52	Yes	No	6	7	8
56	R:R:L290	R:R:W182	10.8078	5.69	No	Yes	1	6	7
57	R:R:F264	R:R:L290	10.6231	6.09	Yes	No	0	4	6
58	R:R:M251	R:R:N215	13.5783	5.61	Yes	Yes	1	8	9
59	R:R:L222	R:R:M244	20.1	4.24	No	No	0	8	6
60	R:R:C223	R:R:M244	18.5055	4.86	No	No	0	4	6
61	R:R:C223	R:R:H227	16.8459	2.95	No	No	0	4	5
62	R:R:H227	R:R:Y226	15.1782	7.62	No	No	0	5	6
63	R:R:R237	R:R:Y226	13.4996	15.43	No	No	0	5	6
64	R:R:E240	R:R:R237	10.2102	5.82	No	No	0	8	5
65	R:R:D304	R:R:L70	11.1419	9.5	No	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A31	4.45	1	Yes	No	0	7	0	1
L:L:?1	R:R:L78	3.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	10.4	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	9.46	1	Yes	No	0	8	0	1
L:L:?1	R:R:H89	7.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:M112	4.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:W182	8.04	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W258	4.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T298	17.68	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q301	8.45	1	Yes	Yes	0	9	0	1
R:R:H89	R:R:P28	9.15	0	No	No	7	6	1	2
R:R:D74	R:R:Q301	7.83	1	Yes	Yes	9	9	2	1
R:R:S181	R:R:V85	4.85	0	Yes	No	8	8	2	1
R:R:H89	R:R:S181	5.58	0	No	Yes	7	8	1	2
R:R:F184	R:R:M112	6.22	0	Yes	No	8	8	2	1
R:R:P119	R:R:Q301	6.32	0	No	Yes	8	9	2	1
R:R:L120	R:R:W258	13.67	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	9.86	1	No	Yes	7	7	2	1
R:R:L290	R:R:Q177	3.99	1	No	No	6	7	2	2
R:R:F184	R:R:W182	6.01	0	Yes	Yes	8	7	2	1
R:R:L290	R:R:W182	5.69	1	No	Yes	6	7	2	1
R:R:L294	R:R:W182	9.11	0	No	Yes	7	7	2	1
R:R:L261	R:R:W258	4.56	0	No	Yes	7	8	2	1
R:R:A297	R:R:W258	5.19	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	9.04	1	No	Yes	9	8	2	1
R:R:Q301	R:R:W258	4.38	1	Yes	Yes	9	8	1	1
R:R:L261	R:R:L294	5.54	0	No	No	7	7	2	2
R:R:N300	R:R:Q301	7.92	1	No	Yes	9	9	2	1
R:R:L262	R:R:W258	3.42	0	No	Yes	8	8	2	1
R:R:G116	R:R:W258	2.81	0	No	Yes	7	8	2	1
R:R:A31	R:R:V86	1.7	0	No	No	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GG5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.56
Number of Linked Nodes	272
Number of Links	285
Number of Hubs	30
Number of Links mediated by Hubs	118
Number of Communities	6
Number of Nodes involved in Communities	37
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	64443
Length Of Smallest Path	3
Average Path Length	15.0454
Length of Longest Path	37
Minimum Path Strength	1.305
Average Path Strength	6.42366
Maximum Path Strength	14.92
Minimum Path Correlation	0.7
Average Path Correlation	0.936719
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	53.576
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.9991
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • response to ketone • response to lipid • response to oxygen-containing compound • response to testosterone • regulation of blood pressure • positive regulation of blood pressure • smooth muscle contraction • muscle contraction • muscle system process • cellular response to stimulus • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • response to external stimulus • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • response to biotic stimulus • cellular response to biotic stimulus • cellular response to chemical stimulus • response to bacterium • cellular response to lipid • cellular process • response to external biotic stimulus • response to molecule of bacterial origin • response to alcohol • response to ethanol • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of locomotion • regulation of cell motility • cell migration involved in sprouting angiogenesis • regulation of blood vessel endothelial cell migration • endothelial cell migration • negative regulation of biological process • negative regulation of endothelial cell migration • negative regulation of blood vessel endothelial cell migration • regulation of cell migration • negative regulation of cellular process • regulation of endothelial cell migration • blood vessel endothelial cell migration • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of cell migration involved in sprouting angiogenesis • sprouting angiogenesis • regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of smooth muscle contraction • regulation of muscle system process • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of body fluid levels • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • response to stress • regulation of response to stress • coagulation • positive regulation of hemostasis • response to wounding • regulation of hemostasis • positive regulation of response to wounding • wound healing • regulation of blood coagulation • hemostasis • blood coagulation • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • defense response • inflammatory response • response to nutrient levels • response to nutrient • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cell periphery • plasma membrane • membrane • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PUC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PUC
Name	(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
Synonyms	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Identifier
Formula	C21 H34 O4
Molecular Weight	350.492
SMILES
PubChem	5311493
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	5
Total Bonds	60
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>9GG5_nogp_Chain_R P C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IIU	A	Lipid	Prostanoid	TXA2	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	6IIV	A	Lipid	Prostanoid	TXA2	Homo sapiens	Daltroban	-	-	3	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	8XJN	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	9GG5	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2025-08-27	To be published
	9GG5 (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.26	2025-08-27	To be published
	9GGG	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-08-27	To be published
	9GGG (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-		3.25	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9GG5_nogp.zip

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