psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A31	6.92	Yes	No	0	0	7
2	L:L:?1	R:R:L78	7.09	Yes	No	0	0	8
3	L:L:?1	R:R:T81	11.86	Yes	No	0	0	7
4	L:L:?1	R:R:V85	10.9	Yes	No	0	0	8
5	L:L:?1	R:R:H89	4.7	Yes	Yes	0	0	7
6	L:L:?1	R:R:M112	4.14	Yes	No	0	0	8
7	L:L:?1	R:R:G116	5	Yes	No	0	0	7
8	L:L:?1	R:R:W182	9.17	Yes	Yes	1	0	7
9	L:L:?1	R:R:W258	7.5	Yes	Yes	1	0	8
10	L:L:?1	R:R:L294	6.08	Yes	No	1	0	7
11	L:L:?1	R:R:T298	10.78	Yes	No	0	0	8
12	L:L:?1	R:R:Q301	8.76	Yes	Yes	1	0	9
13	R:R:C102	R:R:C11	7.28	No	No	7	2	4
14	R:R:C105	R:R:C11	3.64	No	No	7	9	4
15	R:R:E94	R:R:F12	3.5	No	Yes	4	4	3
16	R:R:F12	R:R:W95	20.04	Yes	Yes	4	3	6
17	R:R:F12	R:R:H96	18.1	Yes	No	4	3	2
18	R:R:F12	R:R:V176	13.11	Yes	No	0	3	4
19	R:R:P14	R:R:R13	2.88	No	No	0	3	4
20	R:R:R13	R:R:T175	6.47	No	No	0	4	3
21	R:R:I17	R:R:R22	10.02	No	No	0	3	1
22	R:R:E21	R:R:T18	7.06	Yes	No	0	2	8
23	R:R:E20	R:R:R23	3.49	No	No	0	3	1
24	R:R:E21	R:R:Y178	6.73	Yes	Yes	5	2	3
25	R:R:E21	R:R:R284	12.79	Yes	Yes	5	2	1
26	R:R:H89	R:R:R22	4.51	Yes	No	0	7	1
27	R:R:I25	R:R:L24	5.71	Yes	No	0	3	1
28	R:R:I25	R:R:R295	5.01	Yes	Yes	0	3	8
29	R:R:A26	R:R:P179	3.74	No	No	0	4	8
30	R:R:P28	R:R:S27	3.56	No	No	0	6	7
31	R:R:S27	R:R:W29	4.94	No	No	0	7	3
32	R:R:H89	R:R:P28	10.68	Yes	No	0	7	6
33	R:R:F30	R:R:R295	21.38	No	Yes	0	5	8
34	R:R:F34	R:R:W299	12.03	No	No	0	8	4
35	R:R:C35	R:R:L39	3.17	No	No	0	6	6
36	R:R:C35	R:R:G82	3.92	No	No	0	6	8
37	R:R:G38	R:R:I302	3.53	No	No	0	9	9
38	R:R:F75	R:R:L39	3.65	Yes	No	0	7	6
39	R:R:S41	R:R:W306	12.36	No	No	0	9	8
40	R:R:D74	R:R:N42	4.04	Yes	No	0	9	9
41	R:R:F75	R:R:N42	6.04	Yes	No	0	7	9
42	R:R:N42	R:R:P305	4.89	No	No	0	9	9
43	R:R:F75	R:R:L43	4.87	Yes	No	0	7	5
44	R:R:L319	R:R:L44	4.15	No	No	0	4	5
45	R:R:A45	R:R:V71	3.39	No	No	0	9	8
46	R:R:L46	R:R:V71	2.98	No	No	0	7	8
47	R:R:F75	R:R:L46	6.09	Yes	No	0	7	7
48	R:R:I309	R:R:V48	4.61	Yes	No	3	9	8
49	R:R:V315	R:R:V48	6.41	No	No	3	7	8
50	R:R:L49	R:R:L67	4.15	Yes	No	3	8	8
51	R:R:C68	R:R:L49	7.94	No	Yes	0	5	8
52	R:R:L49	R:R:V71	4.47	Yes	No	0	8	8
53	R:R:I309	R:R:L49	4.28	Yes	Yes	3	9	8
54	R:R:H58	R:R:R53	6.77	Yes	No	0	5	6
55	R:R:G56	R:R:H58	3.18	No	Yes	0	5	5
56	R:R:H58	R:R:S61	4.18	Yes	No	0	5	7
57	R:R:H58	R:R:L64	12.86	Yes	No	0	5	7
58	R:R:R60	R:R:S62	3.95	Yes	No	6	6	6
59	R:R:E129	R:R:R60	6.98	No	Yes	6	9	6
60	R:R:R140	R:R:R60	3.2	No	Yes	6	8	6
61	R:R:Q146	R:R:S61	12.99	No	No	0	5	7
62	R:R:E129	R:R:S62	10.06	No	No	6	9	6
63	R:R:F63	R:R:M126	4.98	No	Yes	0	8	9
64	R:R:F63	R:R:R130	9.62	No	Yes	0	8	9
65	R:R:C68	R:R:L64	3.17	No	No	0	5	7
66	R:R:Q146	R:R:T65	4.25	No	No	0	5	6
67	R:R:A149	R:R:T65	5.03	No	No	0	7	6
68	R:R:T65	R:R:W150	13.34	No	No	0	6	4
69	R:R:A125	R:R:F66	4.16	No	Yes	0	6	7
70	R:R:F66	R:R:M126	3.73	Yes	Yes	0	7	9
71	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
72	R:R:F66	R:R:V153	3.93	Yes	Yes	0	7	7
73	R:R:L67	R:R:M126	4.24	No	Yes	0	8	9
74	R:R:I309	R:R:L67	5.71	Yes	No	3	9	8
75	R:R:D74	R:R:L70	4.07	Yes	Yes	1	9	9
76	R:R:L122	R:R:L70	4.15	No	Yes	0	7	9
77	R:R:D304	R:R:L70	4.07	Yes	Yes	1	9	9
78	R:R:L70	R:R:Y308	3.52	Yes	Yes	1	9	9
79	R:R:L72	R:R:L76	5.54	No	No	0	5	6
80	R:R:F115	R:R:T73	3.89	Yes	No	0	7	9
81	R:R:S118	R:R:T73	6.4	Yes	No	1	7	9
82	R:R:T73	R:R:W157	9.7	No	Yes	1	9	7
83	R:R:D74	R:R:P119	3.22	Yes	No	1	9	8
84	R:R:D74	R:R:Q301	10.44	Yes	Yes	1	9	9
85	R:R:D304	R:R:D74	3.99	Yes	Yes	1	9	9
86	R:R:F115	R:R:G77	10.54	Yes	No	0	7	8
87	R:R:I84	R:R:M108	2.92	No	No	0	5	6
88	R:R:S181	R:R:V85	4.85	No	No	0	8	8
89	R:R:L92	R:R:S87	3	No	No	0	4	5
90	R:R:F93	R:R:S87	6.61	No	No	0	3	5
91	R:R:F93	R:R:Q88	3.51	No	No	0	3	6
92	R:R:Q88	R:R:W95	6.57	No	Yes	0	6	6
93	R:R:Q88	R:R:S181	5.78	No	No	0	6	8
94	R:R:H89	R:R:S181	12.55	Yes	No	0	7	8
95	R:R:F93	R:R:V98	3.93	No	No	0	3	5
96	R:R:E94	R:R:W95	4.36	No	Yes	4	4	6
97	R:R:E94	R:R:H96	6.15	No	No	4	4	2
98	R:R:L104	R:R:W95	4.56	No	Yes	0	6	6
99	R:R:D99	R:R:P100	3.22	No	No	0	5	4
100	R:R:D99	R:R:G101	3.35	No	No	0	5	3
101	R:R:D99	R:R:L104	13.57	No	No	0	5	6
102	R:R:C102	R:R:C105	3.64	No	No	7	2	9
103	R:R:C102	R:R:R106	5.57	No	No	0	2	5
104	R:R:R103	R:R:R106	7.46	No	No	0	2	5
105	R:R:C105	R:R:C183	7.28	No	No	0	9	9
106	R:R:L168	R:R:R106	3.64	No	No	0	5	5
107	R:R:F107	R:R:V111	5.24	No	No	0	6	5
108	R:R:G109	R:R:Y174	10.14	No	Yes	0	8	6
109	R:R:L165	R:R:V110	4.47	No	No	0	5	6
110	R:R:L168	R:R:V110	2.98	No	No	0	5	6
111	R:R:V110	R:R:Y174	5.05	No	Yes	0	6	6
112	R:R:F184	R:R:M112	6.22	Yes	No	0	8	8
113	R:R:G164	R:R:I113	3.53	No	Yes	0	7	7
114	R:R:I113	R:R:Y174	3.63	Yes	Yes	0	7	6
115	R:R:F184	R:R:I113	3.77	Yes	Yes	0	8	7
116	R:R:F200	R:R:I113	5.02	No	Yes	0	8	7
117	R:R:F114	R:R:F115	12.86	No	Yes	0	7	7
118	R:R:F114	R:R:W157	7.02	No	Yes	0	7	7
119	R:R:L117	R:R:L163	5.54	No	Yes	0	7	6
120	R:R:P119	R:R:S118	3.56	No	Yes	1	8	7
121	R:R:L122	R:R:S118	3	No	Yes	0	7	7
122	R:R:S118	R:R:W157	4.94	Yes	Yes	1	7	7
123	R:R:P119	R:R:Q301	4.74	No	Yes	1	8	9
124	R:R:L120	R:R:S207	3	No	No	0	8	7
125	R:R:L120	R:R:W258	14.81	No	Yes	0	8	8
126	R:R:L121	R:R:V156	4.47	No	No	0	6	6
127	R:R:L121	R:R:S207	3	No	No	0	6	7
128	R:R:M126	R:R:Y308	8.38	Yes	Yes	0	9	9
129	R:R:A127	R:R:S211	3.42	No	No	0	9	8
130	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
131	R:R:A127	R:R:N215	3.13	No	Yes	0	9	9
132	R:R:E129	R:R:R140	3.49	No	No	6	9	8
133	R:R:Q246	R:R:R130	3.5	No	Yes	0	8	9
134	R:R:I250	R:R:R130	3.76	Yes	Yes	1	8	9
135	R:R:R130	R:R:Y308	4.12	Yes	Yes	1	9	9
136	R:R:L132	R:R:Y131	3.52	No	Yes	0	6	7
137	R:R:T135	R:R:Y131	13.73	No	Yes	0	7	7
138	R:R:R136	R:R:Y131	3.09	No	Yes	0	5	7
139	R:R:L214	R:R:Y131	4.69	Yes	Yes	0	7	7
140	R:R:V217	R:R:Y131	5.05	No	Yes	0	5	7
141	R:R:L132	R:R:R140	8.5	No	No	0	6	8
142	R:R:R148	R:R:S145	5.27	No	No	0	5	7
143	R:R:V153	R:R:W150	3.68	Yes	No	0	7	4
144	R:R:G154	R:R:V153	3.68	No	Yes	0	2	7
145	R:R:V153	R:R:W157	7.36	Yes	Yes	0	7	7
146	R:R:L161	R:R:L165	8.3	No	No	0	4	5
147	R:R:F196	R:R:L163	3.65	Yes	Yes	2	7	6
148	R:R:L163	R:R:L199	4.15	Yes	No	2	6	4
149	R:R:L166	R:R:P167	3.28	No	Yes	0	8	9
150	R:R:L166	R:R:V171	13.41	No	No	0	8	4
151	R:R:G172	R:R:P167	4.06	No	Yes	2	8	9
152	R:R:P167	R:R:Y174	16.69	Yes	Yes	2	9	6
153	R:R:F196	R:R:P167	10.11	Yes	Yes	2	7	9
154	R:R:G172	R:R:V171	3.68	No	No	0	8	4
155	R:R:F196	R:R:G172	4.52	Yes	No	2	7	8
156	R:R:R173	R:R:T175	3.88	No	No	8	3	3
157	R:R:R173	R:R:T186	11.64	No	No	8	3	4
158	R:R:E190	R:R:R173	5.82	No	No	0	1	3
159	R:R:F196	R:R:Y174	3.09	Yes	Yes	2	7	6
160	R:R:T175	R:R:T186	10.99	No	No	8	3	4
161	R:R:Q177	R:R:W182	14.24	No	Yes	0	7	7
162	R:R:P179	R:R:Y178	16.69	No	Yes	0	8	3
163	R:R:R284	R:R:Y178	15.43	Yes	Yes	5	1	3
164	R:R:E287	R:R:Y178	11.22	No	Yes	5	3	3
165	R:R:F184	R:R:W182	7.02	Yes	Yes	0	8	7
166	R:R:L290	R:R:W182	5.69	No	Yes	0	6	7
167	R:R:L294	R:R:W182	4.56	No	Yes	1	7	7
168	R:R:F184	R:R:L185	7.31	Yes	No	0	8	5
169	R:R:F196	R:R:L185	8.53	Yes	No	0	7	5
170	R:R:D193	R:R:T186	7.23	No	No	0	4	4
171	R:R:L187	R:R:T268	7.37	No	No	0	6	6
172	R:R:G188	R:R:M276	6.99	No	No	0	4	1
173	R:R:A189	R:R:P274	3.74	No	No	0	3	1
174	R:R:L198	R:R:V194	2.98	No	No	0	4	3
175	R:R:L198	R:R:V269	2.98	No	No	0	4	5
176	R:R:L198	R:R:L270	4.15	No	No	0	4	3
177	R:R:A266	R:R:S201	3.42	No	No	0	5	7
178	R:R:G204	R:R:L262	3.42	No	No	0	7	8
179	R:R:L259	R:R:V208	2.98	No	No	0	6	7
180	R:R:F212	R:R:T216	5.19	No	No	9	5	5
181	R:R:F212	R:R:M251	4.98	No	No	9	5	8
182	R:R:L247	R:R:N215	6.87	No	Yes	0	8	9
183	R:R:M251	R:R:N215	4.21	No	Yes	0	8	9
184	R:R:M251	R:R:T216	3.01	No	No	9	8	5
185	R:R:L247	R:R:V219	4.47	No	No	0	8	7
186	R:R:L248	R:R:V219	4.47	No	No	0	6	7
187	R:R:E240	R:R:L222	6.63	Yes	No	0	8	8
188	R:R:L222	R:R:M244	5.65	No	No	0	8	6
189	R:R:C223	R:R:H227	5.9	No	No	0	4	5
190	R:R:C223	R:R:M244	4.86	No	No	0	4	6
191	R:R:E240	R:R:V225	7.13	Yes	No	0	8	7
192	R:R:H227	R:R:Y226	7.62	No	Yes	0	5	6
193	R:R:E230	R:R:Y226	3.37	No	Yes	0	3	6
194	R:R:R237	R:R:Y226	42.18	Yes	Yes	10	5	6
195	R:R:E240	R:R:Y226	3.37	Yes	Yes	10	8	6
196	R:R:E230	R:R:Q234	8.92	No	No	0	3	4
197	R:R:P236	R:R:R235	2.88	No	No	0	3	7
198	R:R:E240	R:R:R237	5.82	Yes	Yes	10	8	5
199	R:R:R237	R:R:V241	19.61	Yes	No	0	5	4
200	R:R:M244	R:R:R237	7.44	No	Yes	0	6	5
201	R:R:E242	R:R:R312	3.49	No	No	0	8	9
202	R:R:E242	R:R:R313	12.79	No	No	0	8	6
203	R:R:L247	R:R:M243	4.24	No	No	0	8	8
204	R:R:Q246	R:R:R312	24.53	No	No	0	8	9
205	R:R:I250	R:R:V307	3.07	Yes	No	1	8	8
206	R:R:I250	R:R:Y308	9.67	Yes	Yes	1	8	9
207	R:R:L303	R:R:V253	2.98	No	No	0	7	7
208	R:R:L259	R:R:S255	3	No	No	0	6	5
209	R:R:L262	R:R:W258	4.56	No	Yes	0	8	8
210	R:R:N300	R:R:W258	13.56	Yes	Yes	1	9	8
211	R:R:Q301	R:R:W258	3.29	Yes	Yes	1	9	8
212	R:R:I265	R:R:L261	4.28	No	No	0	7	7
213	R:R:A297	R:R:L261	3.15	No	No	0	8	7
214	R:R:Q267	R:R:V263	4.3	No	No	0	4	6
215	R:R:F264	R:R:T268	9.08	Yes	No	0	4	6
216	R:R:E289	R:R:F264	3.5	No	Yes	0	1	4
217	R:R:F264	R:R:L290	4.87	Yes	No	0	4	6
218	R:R:F264	R:R:Y293	5.16	Yes	No	0	4	7
219	R:R:G280	R:R:M276	5.24	No	No	0	5	1
220	R:R:P278	R:R:S277	3.56	No	No	0	7	2
221	R:R:L282	R:R:T286	2.95	No	No	0	4	2
222	R:R:S283	R:R:T285	3.2	No	No	0	1	1
223	R:R:S283	R:R:T286	3.2	No	No	0	1	2
224	R:R:E287	R:R:R284	3.49	No	Yes	5	3	1
225	R:R:K288	R:R:T285	12.01	No	No	0	1	1
226	R:R:L291	R:R:R295	14.58	No	Yes	0	7	8
227	R:R:I302	R:R:W299	12.92	No	No	0	9	4
228	R:R:N300	R:R:Q301	7.92	Yes	Yes	1	9	9
229	R:R:D304	R:R:N300	10.77	Yes	Yes	1	9	9
230	R:R:D304	R:R:Y308	6.9	Yes	Yes	1	9	9
231	R:R:L310	R:R:W306	10.25	No	No	0	8	8
232	R:R:F311	R:R:W306	4.01	No	No	0	7	8
233	R:R:V307	R:R:Y308	3.79	No	Yes	1	8	9
234	R:R:I309	R:R:L310	2.85	Yes	No	0	9	8
235	R:R:I309	R:R:V315	4.61	Yes	No	3	9	7
236	R:R:R312	R:R:V315	3.92	No	No	0	9	7
237	R:R:Q320	R:R:R317	4.67	No	No	0	3	5
238	R:R:P321	R:R:Q320	7.9	No	No	0	4	3
239	R:R:I250	R:R:N215	2.83	Yes	Yes	0	8	9
240	R:R:L222	R:R:M243	2.83	No	No	0	8	8
241	R:R:L282	R:R:M276	2.83	No	No	0	4	1
242	R:R:G69	R:R:W157	2.81	No	Yes	0	7	7
243	R:R:P260	R:R:Y293	2.78	No	No	0	9	7
244	R:R:L310	R:R:L44	2.77	No	No	0	8	5
245	R:R:A160	R:R:F114	2.77	No	No	0	7	7
246	R:R:L163	R:R:L203	2.77	Yes	No	2	6	5
247	R:R:L166	R:R:L169	2.77	No	No	0	8	4
248	R:R:L199	R:R:L203	2.77	No	No	2	4	5
249	R:R:L210	R:R:L214	2.77	No	Yes	0	6	7
250	R:R:E21	R:R:I25	2.73	Yes	Yes	0	2	3
251	R:R:P179	R:R:W182	2.7	No	Yes	0	8	7
252	R:R:E287	R:R:L282	2.65	No	No	0	3	4
253	R:R:F34	R:R:S33	2.64	No	No	0	8	4
254	R:R:F115	R:R:V111	2.62	Yes	No	0	7	5
255	R:R:S218	R:R:Y131	2.54	No	Yes	0	9	7
256	R:R:F200	R:R:I265	2.51	No	No	0	8	7
257	R:R:F75	R:R:L76	2.44	Yes	No	0	7	6
258	R:R:F115	R:R:L76	2.44	Yes	No	0	7	6
259	R:R:Q234	R:R:R235	2.34	No	No	0	4	7
260	R:R:M108	R:R:W95	2.33	No	Yes	0	6	6
261	R:R:M108	R:R:W182	2.33	No	Yes	0	6	7
262	R:R:L303	R:R:W299	2.28	No	No	0	7	4
263	R:R:F34	R:R:R295	2.14	No	Yes	0	8	8
264	R:R:G55	R:R:G56	2.11	No	No	0	3	5
265	R:R:G204	R:R:G205	2.11	No	No	0	7	5
266	R:R:A50	R:R:G51	1.95	No	No	0	3	7
267	R:R:A195	R:R:G192	1.95	No	No	0	5	1
268	R:R:P273	R:R:P274	1.95	No	No	0	1	1
269	R:R:G192	R:R:S191	1.86	No	No	0	1	2
270	R:R:G38	R:R:V37	1.84	No	No	0	9	6
271	R:R:G180	R:R:V176	1.84	No	No	0	5	4
272	R:R:G197	R:R:V269	1.84	No	No	0	6	5
273	R:R:G205	R:R:V208	1.84	No	No	0	5	7
274	R:R:G209	R:R:V208	1.84	No	No	0	3	7
275	R:R:G197	R:R:I265	1.76	No	No	0	6	7
276	R:R:G123	R:R:M126	1.75	No	Yes	0	8	9
277	R:R:A124	R:R:S211	1.71	No	No	0	6	8
278	R:R:G249	R:R:L248	1.71	No	No	0	5	6
279	R:R:A32	R:R:V86	1.7	No	No	0	5	7
280	R:R:A97	R:R:V98	1.7	No	No	0	4	5
281	R:R:D193	R:R:G188	1.68	No	No	0	4	4
282	R:R:A275	R:R:T268	1.68	No	No	0	1	6
283	R:R:G51	R:R:Q54	1.64	No	No	0	7	5
284	R:R:S47	R:R:V48	1.62	No	No	0	4	8
285	R:R:S255	R:R:V256	1.62	No	No	0	5	6
286	R:R:V111	R:R:V80	1.6	No	No	0	5	6
287	R:R:V252	R:R:V256	1.6	No	No	0	5	6
288	R:R:T221	R:R:V225	1.59	No	No	0	7	7
289	R:R:A52	R:R:L64	1.58	No	No	0	6	7
290	R:R:C257	R:R:N300	1.57	No	Yes	0	9	9
291	R:R:I134	R:R:S218	1.55	No	No	0	8	9
292	R:R:L214	R:R:S128	1.5	Yes	No	0	7	6
293	R:R:L262	R:R:S201	1.5	No	No	0	8	7
294	R:R:I25	R:R:I292	1.47	Yes	No	0	3	4
295	R:R:L79	R:R:T83	1.47	No	No	0	6	8
296	R:R:P137	R:R:R136	1.44	No	No	0	8	5
297	R:R:E20	R:R:T18	1.41	No	No	0	3	8
298	R:R:L39	R:R:L79	1.38	No	No	0	6	6
299	R:R:R136	R:R:S139	1.32	No	No	0	5	4
300	R:R:R147	R:R:S145	1.32	No	No	0	5	7
301	R:R:D238	R:R:E242	1.3	No	No	0	5	8
302	R:R:R284	R:R:T15	1.29	Yes	No	0	1	4
303	R:R:R60	R:R:T59	1.29	Yes	No	0	6	7
304	R:R:F212	R:R:L213	1.22	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.74167	12	1	0
2	R:R:F12	13.6875	4	4	3
3	R:R:E21	7.3275	4	5	2
4	R:R:I25	3.73	4	0	3
5	R:R:L49	5.21	4	3	8
6	R:R:H58	6.7475	4	0	5
7	R:R:R60	3.855	4	6	6
8	R:R:F66	4.5775	4	0	7
9	R:R:L70	3.9525	4	1	9
10	R:R:D74	5.152	5	1	9
11	R:R:F75	4.618	5	0	7
12	R:R:H89	8.11	4	0	7
13	R:R:W95	7.572	5	4	6
14	R:R:I113	3.9875	4	0	7
15	R:R:F115	6.47	5	0	7
16	R:R:S118	4.475	4	1	7
17	R:R:M126	4.616	5	0	9
18	R:R:R130	5.25	4	1	9
19	R:R:Y131	5.43667	6	0	7
20	R:R:V153	4.6625	4	0	7
21	R:R:W157	6.366	5	1	7
22	R:R:L163	4.0275	4	2	6
23	R:R:P167	8.535	4	2	9
24	R:R:Y174	7.72	5	2	6
25	R:R:Y178	12.5175	4	5	3
26	R:R:W182	6.53	7	1	7
27	R:R:F184	6.08	4	0	8
28	R:R:F196	5.98	5	2	7
29	R:R:L214	3.0275	4	0	7
30	R:R:N215	4.26	4	0	9
31	R:R:Y226	14.135	4	10	6
32	R:R:R237	18.7625	4	10	5
33	R:R:E240	5.7375	4	10	8
34	R:R:I250	4.8325	4	1	8
35	R:R:W258	8.744	5	1	8
36	R:R:F264	5.6525	4	0	4
37	R:R:R284	8.25	4	5	1
38	R:R:R295	10.7775	4	0	8
39	R:R:N300	8.455	4	1	9
40	R:R:Q301	7.03	5	1	9
41	R:R:D304	6.4325	4	1	9
42	R:R:Y308	6.06333	6	1	9
43	R:R:I309	4.412	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M112	32.4715	4.14	Yes	No	0	0	8
2	R:R:F184	R:R:M112	31.672	6.22	Yes	No	0	8	8
3	R:R:F184	R:R:I113	46.7873	3.77	Yes	Yes	0	8	7
4	R:R:I113	R:R:Y174	27.5187	3.63	Yes	Yes	0	7	6
5	R:R:V110	R:R:Y174	18.5138	5.05	No	Yes	0	6	6
6	R:R:L168	R:R:V110	13.0026	2.98	No	No	0	5	6
7	R:R:L168	R:R:R106	11.1565	3.64	No	No	0	5	5
8	L:L:?1	R:R:W182	82.6243	9.17	Yes	Yes	1	0	7
9	R:R:F184	R:R:W182	36.6715	7.02	Yes	Yes	0	8	7
10	R:R:M108	R:R:W182	13.8177	2.33	No	Yes	0	6	7
11	R:R:M108	R:R:W95	11.9638	2.33	No	Yes	0	6	6
12	R:R:P179	R:R:W182	37.5411	2.7	No	Yes	0	8	7
13	R:R:P179	R:R:Y178	35.7514	16.69	No	Yes	0	8	3
14	R:R:E287	R:R:Y178	16.1035	11.22	No	Yes	5	3	3
15	R:R:E287	R:R:L282	15.6989	2.65	No	No	0	3	4
16	R:R:L282	R:R:M276	10.5534	2.83	No	No	0	4	1
17	L:L:?1	R:R:H89	12.2206	4.7	Yes	Yes	0	0	7
18	R:R:E21	R:R:Y178	17.899	6.73	Yes	Yes	5	2	3
19	R:R:E21	R:R:I25	14.5356	2.73	Yes	Yes	0	2	3
20	R:R:I25	R:R:R295	11.532	5.01	Yes	Yes	0	3	8
21	L:L:?1	R:R:Q301	100	8.76	Yes	Yes	1	0	9
22	R:R:D74	R:R:Q301	63.7389	10.44	Yes	Yes	1	9	9
23	R:R:D74	R:R:N42	10.7519	4.04	Yes	No	0	9	9
24	L:L:?1	R:R:W258	33.2983	7.5	Yes	Yes	1	0	8
25	R:R:N300	R:R:W258	30.8978	13.56	Yes	Yes	1	9	8
26	R:R:D304	R:R:N300	58.2667	10.77	Yes	Yes	1	9	9
27	R:R:D304	R:R:Y308	86.6589	6.9	Yes	Yes	1	9	9
28	R:R:M126	R:R:Y308	38.0877	8.38	Yes	Yes	0	9	9
29	R:R:L67	R:R:M126	28.7929	4.24	No	Yes	0	8	9
30	R:R:I309	R:R:L67	14.874	5.71	Yes	No	3	9	8
31	R:R:N300	R:R:Q301	28.4291	7.92	Yes	Yes	1	9	9
32	R:R:D304	R:R:D74	29.4699	3.99	Yes	Yes	1	9	9
33	R:R:D74	R:R:L70	29.8142	4.07	Yes	Yes	1	9	9
34	R:R:L70	R:R:Y308	30.6507	3.52	Yes	Yes	1	9	9
35	R:R:R130	R:R:Y308	11.1448	4.12	Yes	Yes	1	9	9
36	R:R:L49	R:R:L67	12.4774	4.15	Yes	No	3	8	8
37	R:R:C68	R:R:L49	13.3761	7.94	No	Yes	0	5	8
38	R:R:C68	R:R:L64	11.5028	3.17	No	No	0	5	7
39	R:R:I250	R:R:Y308	73.1563	9.67	Yes	Yes	1	8	9
40	R:R:I250	R:R:N215	72.7653	2.83	Yes	Yes	0	8	9
41	R:R:A127	R:R:N215	33.0474	3.13	No	Yes	0	9	9
42	R:R:A127	R:R:L214	28.4311	3.15	No	Yes	0	9	7
43	R:R:L214	R:R:Y131	23.7798	4.69	Yes	Yes	0	7	7
44	R:R:L132	R:R:Y131	11.2051	3.52	No	Yes	0	6	7
45	R:R:Q88	R:R:S181	10.071	5.78	No	No	0	6	8
46	R:R:F200	R:R:I113	16.6832	5.02	No	Yes	0	8	7
47	R:R:F184	R:R:L185	19.7899	7.31	Yes	No	0	8	5
48	R:R:F196	R:R:L185	18.0119	8.53	Yes	No	0	7	5
49	R:R:F200	R:R:I265	14.8449	2.51	No	No	0	8	7
50	R:R:L247	R:R:N215	34.3255	6.87	No	Yes	0	8	9
51	R:R:L247	R:R:M243	28.1743	4.24	No	No	0	8	8
52	R:R:L222	R:R:M243	26.7075	2.83	No	No	0	8	8
53	R:R:E240	R:R:L222	17.4263	6.63	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A31	6.92	1	Yes	No	0	7	0	1
L:L:?1	R:R:L78	7.09	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	11.86	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	10.9	1	Yes	No	0	8	0	1
L:L:?1	R:R:H89	4.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M112	4.14	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	5	1	Yes	No	0	7	0	1
L:L:?1	R:R:W182	9.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W258	7.5	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L294	6.08	1	Yes	No	0	7	0	1
L:L:?1	R:R:T298	10.78	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q301	8.76	1	Yes	Yes	0	9	0	1
R:R:H89	R:R:R22	4.51	0	Yes	No	7	1	1	2
R:R:H89	R:R:P28	10.68	0	Yes	No	7	6	1	2
R:R:D74	R:R:P119	3.22	1	Yes	No	9	8	2	2
R:R:D74	R:R:Q301	10.44	1	Yes	Yes	9	9	2	1
R:R:S181	R:R:V85	4.85	0	No	No	8	8	2	1
R:R:H89	R:R:S181	12.55	0	Yes	No	7	8	1	2
R:R:F184	R:R:M112	6.22	0	Yes	No	8	8	2	1
R:R:P119	R:R:Q301	4.74	1	No	Yes	8	9	2	1
R:R:L120	R:R:W258	14.81	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	14.24	0	No	Yes	7	7	2	1
R:R:F184	R:R:W182	7.02	0	Yes	Yes	8	7	2	1
R:R:L290	R:R:W182	5.69	0	No	Yes	6	7	2	1
R:R:L294	R:R:W182	4.56	1	No	Yes	7	7	1	1
R:R:L262	R:R:W258	4.56	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	13.56	1	Yes	Yes	9	8	2	1
R:R:Q301	R:R:W258	3.29	1	Yes	Yes	9	8	1	1
R:R:N300	R:R:Q301	7.92	1	Yes	Yes	9	9	2	1
R:R:P179	R:R:W182	2.7	0	No	Yes	8	7	2	1
R:R:M108	R:R:W182	2.33	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GGG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	273
Number of Links	304
Number of Hubs	43
Number of Links mediated by Hubs	157
Number of Communities	10
Number of Nodes involved in Communities	53
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	88274
Length Of Smallest Path	3
Average Path Length	13.8558
Length of Longest Path	28
Minimum Path Strength	1.38
Average Path Strength	6.29614
Maximum Path Strength	30.895
Minimum Path Correlation	0.7
Average Path Correlation	0.926666
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.0037
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	59.4149
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>9GGG_nogp_Chain_R P C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IIU	A	Lipid	Prostanoid	TXA2	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	6IIV	A	Lipid	Prostanoid	TXA2	Homo sapiens	Daltroban	-	-	3	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	8XJN	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	9GG5	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2025-08-27	To be published
	9GG5 (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.26	2025-08-27	To be published
	9GGG	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-08-27	To be published
	9GGG (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-		3.25	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9GGG_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.