psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A31	6.67	Yes	No	0	0	7
2	L:L:?1	R:R:L78	6.84	Yes	No	0	0	8
3	L:L:?1	R:R:T81	11.44	Yes	No	0	0	7
4	L:L:?1	R:R:V85	10.52	Yes	No	0	0	8
5	L:L:?1	R:R:H89	4.54	Yes	Yes	0	0	7
6	L:L:?1	R:R:M112	3.99	Yes	No	0	0	8
7	L:L:?1	R:R:G116	4.83	Yes	No	0	0	7
8	L:L:?1	R:R:W182	8.84	Yes	Yes	1	0	7
9	L:L:?1	R:R:W258	7.24	Yes	Yes	1	0	8
10	L:L:?1	R:R:L294	5.86	Yes	No	1	0	7
11	L:L:?1	R:R:T298	10.4	Yes	No	0	0	8
12	L:L:?1	R:R:Q301	8.46	Yes	Yes	1	0	9
13	R:R:C102	R:R:C11	7.28	No	No	7	2	4
14	R:R:C105	R:R:C11	3.64	No	No	7	9	4
15	R:R:E94	R:R:F12	3.5	No	Yes	4	4	3
16	R:R:F12	R:R:W95	20.04	Yes	Yes	4	3	6
17	R:R:F12	R:R:H96	18.1	Yes	No	4	3	2
18	R:R:F12	R:R:V176	13.11	Yes	No	0	3	4
19	R:R:P14	R:R:R13	2.88	No	No	0	3	4
20	R:R:R13	R:R:T175	6.47	No	No	0	4	3
21	R:R:I17	R:R:R22	10.02	No	No	0	3	1
22	R:R:E21	R:R:T18	7.06	Yes	No	0	2	8
23	R:R:E20	R:R:R23	3.49	No	No	0	3	1
24	R:R:E21	R:R:Y178	6.73	Yes	Yes	5	2	3
25	R:R:E21	R:R:R284	12.79	Yes	Yes	5	2	1
26	R:R:H89	R:R:R22	4.51	Yes	No	0	7	1
27	R:R:I25	R:R:L24	5.71	Yes	No	0	3	1
28	R:R:I25	R:R:R295	5.01	Yes	Yes	0	3	8
29	R:R:A26	R:R:P179	3.74	No	No	0	4	8
30	R:R:P28	R:R:S27	3.56	No	No	0	6	7
31	R:R:S27	R:R:W29	4.94	No	No	0	7	3
32	R:R:H89	R:R:P28	10.68	Yes	No	0	7	6
33	R:R:F30	R:R:R295	21.38	No	Yes	0	5	8
34	R:R:F34	R:R:W299	12.03	No	No	0	8	4
35	R:R:C35	R:R:L39	3.17	No	No	0	6	6
36	R:R:C35	R:R:G82	3.92	No	No	0	6	8
37	R:R:G38	R:R:I302	3.53	No	No	0	9	9
38	R:R:F75	R:R:L39	3.65	Yes	No	0	7	6
39	R:R:S41	R:R:W306	12.36	No	No	0	9	8
40	R:R:D74	R:R:N42	4.04	Yes	No	0	9	9
41	R:R:F75	R:R:N42	6.04	Yes	No	0	7	9
42	R:R:N42	R:R:P305	4.89	No	No	0	9	9
43	R:R:F75	R:R:L43	4.87	Yes	No	0	7	5
44	R:R:L319	R:R:L44	4.15	No	No	0	4	5
45	R:R:A45	R:R:V71	3.39	No	No	0	9	8
46	R:R:L46	R:R:V71	2.98	No	No	0	7	8
47	R:R:F75	R:R:L46	6.09	Yes	No	0	7	7
48	R:R:I309	R:R:V48	4.61	Yes	No	3	9	8
49	R:R:V315	R:R:V48	6.41	No	No	3	7	8
50	R:R:L49	R:R:L67	4.15	Yes	No	3	8	8
51	R:R:C68	R:R:L49	7.94	No	Yes	0	5	8
52	R:R:L49	R:R:V71	4.47	Yes	No	0	8	8
53	R:R:I309	R:R:L49	4.28	Yes	Yes	3	9	8
54	R:R:H58	R:R:R53	6.77	Yes	No	0	5	6
55	R:R:G56	R:R:H58	3.18	No	Yes	0	5	5
56	R:R:H58	R:R:S61	4.18	Yes	No	0	5	7
57	R:R:H58	R:R:L64	12.86	Yes	No	0	5	7
58	R:R:R60	R:R:S62	3.95	Yes	No	6	6	6
59	R:R:E129	R:R:R60	6.98	No	Yes	6	9	6
60	R:R:R140	R:R:R60	3.2	No	Yes	6	8	6
61	R:R:Q146	R:R:S61	12.99	No	No	0	5	7
62	R:R:E129	R:R:S62	10.06	No	No	6	9	6
63	R:R:F63	R:R:M126	4.98	No	Yes	0	8	9
64	R:R:F63	R:R:R130	9.62	No	Yes	0	8	9
65	R:R:C68	R:R:L64	3.17	No	No	0	5	7
66	R:R:Q146	R:R:T65	4.25	No	No	0	5	6
67	R:R:A149	R:R:T65	5.03	No	No	0	7	6
68	R:R:T65	R:R:W150	13.34	No	No	0	6	4
69	R:R:A125	R:R:F66	4.16	No	Yes	0	6	7
70	R:R:F66	R:R:M126	3.73	Yes	Yes	0	7	9
71	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
72	R:R:F66	R:R:V153	3.93	Yes	Yes	0	7	7
73	R:R:L67	R:R:M126	4.24	No	Yes	0	8	9
74	R:R:I309	R:R:L67	5.71	Yes	No	3	9	8
75	R:R:D74	R:R:L70	4.07	Yes	Yes	1	9	9
76	R:R:L122	R:R:L70	4.15	No	Yes	0	7	9
77	R:R:D304	R:R:L70	4.07	Yes	Yes	1	9	9
78	R:R:L70	R:R:Y308	3.52	Yes	Yes	1	9	9
79	R:R:L72	R:R:L76	5.54	No	No	0	5	6
80	R:R:F115	R:R:T73	3.89	Yes	No	0	7	9
81	R:R:S118	R:R:T73	6.4	Yes	No	1	7	9
82	R:R:T73	R:R:W157	9.7	No	Yes	1	9	7
83	R:R:D74	R:R:P119	3.22	Yes	No	1	9	8
84	R:R:D74	R:R:Q301	10.44	Yes	Yes	1	9	9
85	R:R:D304	R:R:D74	3.99	Yes	Yes	1	9	9
86	R:R:F115	R:R:G77	10.54	Yes	No	0	7	8
87	R:R:I84	R:R:M108	2.92	No	No	0	5	6
88	R:R:S181	R:R:V85	4.85	No	No	0	8	8
89	R:R:L92	R:R:S87	3	No	No	0	4	5
90	R:R:F93	R:R:S87	6.61	No	No	0	3	5
91	R:R:F93	R:R:Q88	3.51	No	No	0	3	6
92	R:R:Q88	R:R:W95	6.57	No	Yes	0	6	6
93	R:R:Q88	R:R:S181	5.78	No	No	0	6	8
94	R:R:H89	R:R:S181	12.55	Yes	No	0	7	8
95	R:R:F93	R:R:V98	3.93	No	No	0	3	5
96	R:R:E94	R:R:W95	4.36	No	Yes	4	4	6
97	R:R:E94	R:R:H96	6.15	No	No	4	4	2
98	R:R:L104	R:R:W95	4.56	No	Yes	0	6	6
99	R:R:D99	R:R:P100	3.22	No	No	0	5	4
100	R:R:D99	R:R:G101	3.35	No	No	0	5	3
101	R:R:D99	R:R:L104	13.57	No	No	0	5	6
102	R:R:C102	R:R:C105	3.64	No	No	7	2	9
103	R:R:C102	R:R:R106	5.57	No	No	0	2	5
104	R:R:R103	R:R:R106	7.46	No	No	0	2	5
105	R:R:C105	R:R:C183	7.28	No	No	0	9	9
106	R:R:L168	R:R:R106	3.64	No	No	0	5	5
107	R:R:F107	R:R:V111	5.24	No	No	0	6	5
108	R:R:G109	R:R:Y174	10.14	No	Yes	0	8	6
109	R:R:L165	R:R:V110	4.47	No	No	0	5	6
110	R:R:L168	R:R:V110	2.98	No	No	0	5	6
111	R:R:V110	R:R:Y174	5.05	No	Yes	0	6	6
112	R:R:F184	R:R:M112	6.22	Yes	No	0	8	8
113	R:R:G164	R:R:I113	3.53	No	Yes	0	7	7
114	R:R:I113	R:R:Y174	3.63	Yes	Yes	0	7	6
115	R:R:F184	R:R:I113	3.77	Yes	Yes	0	8	7
116	R:R:F200	R:R:I113	5.02	No	Yes	0	8	7
117	R:R:F114	R:R:F115	12.86	No	Yes	0	7	7
118	R:R:F114	R:R:W157	7.02	No	Yes	0	7	7
119	R:R:L117	R:R:L163	5.54	No	Yes	0	7	6
120	R:R:P119	R:R:S118	3.56	No	Yes	1	8	7
121	R:R:L122	R:R:S118	3	No	Yes	0	7	7
122	R:R:S118	R:R:W157	4.94	Yes	Yes	1	7	7
123	R:R:P119	R:R:Q301	4.74	No	Yes	1	8	9
124	R:R:L120	R:R:S207	3	No	No	0	8	7
125	R:R:L120	R:R:W258	14.81	No	Yes	0	8	8
126	R:R:L121	R:R:V156	4.47	No	No	0	6	6
127	R:R:L121	R:R:S207	3	No	No	0	6	7
128	R:R:M126	R:R:Y308	8.38	Yes	Yes	0	9	9
129	R:R:A127	R:R:S211	3.42	No	No	0	9	8
130	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
131	R:R:A127	R:R:N215	3.13	No	Yes	0	9	9
132	R:R:E129	R:R:R140	3.49	No	No	6	9	8
133	R:R:Q246	R:R:R130	3.5	No	Yes	0	8	9
134	R:R:I250	R:R:R130	3.76	Yes	Yes	1	8	9
135	R:R:R130	R:R:Y308	4.12	Yes	Yes	1	9	9
136	R:R:L132	R:R:Y131	3.52	No	Yes	0	6	7
137	R:R:T135	R:R:Y131	13.73	No	Yes	0	7	7
138	R:R:R136	R:R:Y131	3.09	No	Yes	0	5	7
139	R:R:L214	R:R:Y131	4.69	Yes	Yes	0	7	7
140	R:R:V217	R:R:Y131	5.05	No	Yes	0	5	7
141	R:R:L132	R:R:R140	8.5	No	No	0	6	8
142	R:R:R148	R:R:S145	5.27	No	No	0	5	7
143	R:R:V153	R:R:W150	3.68	Yes	No	0	7	4
144	R:R:G154	R:R:V153	3.68	No	Yes	0	2	7
145	R:R:V153	R:R:W157	7.36	Yes	Yes	0	7	7
146	R:R:L161	R:R:L165	8.3	No	No	0	4	5
147	R:R:F196	R:R:L163	3.65	Yes	Yes	2	7	6
148	R:R:L163	R:R:L199	4.15	Yes	No	2	6	4
149	R:R:L166	R:R:P167	3.28	No	Yes	0	8	9
150	R:R:L166	R:R:V171	13.41	No	No	0	8	4
151	R:R:G172	R:R:P167	4.06	No	Yes	2	8	9
152	R:R:P167	R:R:Y174	16.69	Yes	Yes	2	9	6
153	R:R:F196	R:R:P167	10.11	Yes	Yes	2	7	9
154	R:R:G172	R:R:V171	3.68	No	No	0	8	4
155	R:R:F196	R:R:G172	4.52	Yes	No	2	7	8
156	R:R:R173	R:R:T175	3.88	No	No	8	3	3
157	R:R:R173	R:R:T186	11.64	No	No	8	3	4
158	R:R:E190	R:R:R173	5.82	No	No	0	1	3
159	R:R:F196	R:R:Y174	3.09	Yes	Yes	2	7	6
160	R:R:T175	R:R:T186	10.99	No	No	8	3	4
161	R:R:Q177	R:R:W182	14.24	No	Yes	0	7	7
162	R:R:P179	R:R:Y178	16.69	No	Yes	0	8	3
163	R:R:R284	R:R:Y178	15.43	Yes	Yes	5	1	3
164	R:R:E287	R:R:Y178	11.22	No	Yes	5	3	3
165	R:R:F184	R:R:W182	7.02	Yes	Yes	0	8	7
166	R:R:L290	R:R:W182	5.69	No	Yes	0	6	7
167	R:R:L294	R:R:W182	4.56	No	Yes	1	7	7
168	R:R:F184	R:R:L185	7.31	Yes	No	0	8	5
169	R:R:F196	R:R:L185	8.53	Yes	No	0	7	5
170	R:R:D193	R:R:T186	7.23	No	No	0	4	4
171	R:R:L187	R:R:T268	7.37	No	No	0	6	6
172	R:R:G188	R:R:M276	6.99	No	No	0	4	1
173	R:R:A189	R:R:P274	3.74	No	No	0	3	1
174	R:R:L198	R:R:V194	2.98	No	No	0	4	3
175	R:R:L198	R:R:V269	2.98	No	No	0	4	5
176	R:R:L198	R:R:L270	4.15	No	No	0	4	3
177	R:R:A266	R:R:S201	3.42	No	No	0	5	7
178	R:R:G204	R:R:L262	3.42	No	No	0	7	8
179	R:R:L259	R:R:V208	2.98	No	No	0	6	7
180	R:R:F212	R:R:T216	5.19	No	No	9	5	5
181	R:R:F212	R:R:M251	4.98	No	No	9	5	8
182	R:R:L247	R:R:N215	6.87	No	Yes	0	8	9
183	R:R:M251	R:R:N215	4.21	No	Yes	0	8	9
184	R:R:M251	R:R:T216	3.01	No	No	9	8	5
185	R:R:L247	R:R:V219	4.47	No	No	0	8	7
186	R:R:L248	R:R:V219	4.47	No	No	0	6	7
187	R:R:E240	R:R:L222	6.63	Yes	No	0	8	8
188	R:R:L222	R:R:M244	5.65	No	No	0	8	6
189	R:R:C223	R:R:H227	5.9	No	No	0	4	5
190	R:R:C223	R:R:M244	4.86	No	No	0	4	6
191	R:R:E240	R:R:V225	7.13	Yes	No	0	8	7
192	R:R:H227	R:R:Y226	7.62	No	Yes	0	5	6
193	R:R:E230	R:R:Y226	3.37	No	Yes	0	3	6
194	R:R:R237	R:R:Y226	42.18	Yes	Yes	10	5	6
195	R:R:E240	R:R:Y226	3.37	Yes	Yes	10	8	6
196	R:R:E230	R:R:Q234	8.92	No	No	0	3	4
197	R:R:P236	R:R:R235	2.88	No	No	0	3	7
198	R:R:E240	R:R:R237	5.82	Yes	Yes	10	8	5
199	R:R:R237	R:R:V241	19.61	Yes	No	0	5	4
200	R:R:M244	R:R:R237	7.44	No	Yes	0	6	5
201	R:R:E242	R:R:R312	3.49	No	No	0	8	9
202	R:R:E242	R:R:R313	12.79	No	No	0	8	6
203	R:R:L247	R:R:M243	4.24	No	No	0	8	8
204	R:R:Q246	R:R:R312	24.53	No	No	0	8	9
205	R:R:I250	R:R:V307	3.07	Yes	No	1	8	8
206	R:R:I250	R:R:Y308	9.67	Yes	Yes	1	8	9
207	R:R:L303	R:R:V253	2.98	No	No	0	7	7
208	R:R:L259	R:R:S255	3	No	No	0	6	5
209	R:R:L262	R:R:W258	4.56	No	Yes	0	8	8
210	R:R:N300	R:R:W258	13.56	Yes	Yes	1	9	8
211	R:R:Q301	R:R:W258	3.29	Yes	Yes	1	9	8
212	R:R:I265	R:R:L261	4.28	No	No	0	7	7
213	R:R:A297	R:R:L261	3.15	No	No	0	8	7
214	R:R:Q267	R:R:V263	4.3	No	No	0	4	6
215	R:R:F264	R:R:T268	9.08	Yes	No	0	4	6
216	R:R:E289	R:R:F264	3.5	No	Yes	0	1	4
217	R:R:F264	R:R:L290	4.87	Yes	No	0	4	6
218	R:R:F264	R:R:Y293	5.16	Yes	No	0	4	7
219	R:R:G280	R:R:M276	5.24	No	No	0	5	1
220	R:R:P278	R:R:S277	3.56	No	No	0	7	2
221	R:R:L282	R:R:T286	2.95	No	No	0	4	2
222	R:R:S283	R:R:T285	3.2	No	No	0	1	1
223	R:R:S283	R:R:T286	3.2	No	No	0	1	2
224	R:R:E287	R:R:R284	3.49	No	Yes	5	3	1
225	R:R:K288	R:R:T285	12.01	No	No	0	1	1
226	R:R:L291	R:R:R295	14.58	No	Yes	0	7	8
227	R:R:I302	R:R:W299	12.92	No	No	0	9	4
228	R:R:N300	R:R:Q301	7.92	Yes	Yes	1	9	9
229	R:R:D304	R:R:N300	10.77	Yes	Yes	1	9	9
230	R:R:D304	R:R:Y308	6.9	Yes	Yes	1	9	9
231	R:R:L310	R:R:W306	10.25	No	No	0	8	8
232	R:R:F311	R:R:W306	4.01	No	No	0	7	8
233	R:R:V307	R:R:Y308	3.79	No	Yes	1	8	9
234	R:R:I309	R:R:L310	2.85	Yes	No	0	9	8
235	R:R:I309	R:R:V315	4.61	Yes	No	3	9	7
236	R:R:R312	R:R:V315	3.92	No	No	0	9	7
237	R:R:Q320	R:R:R317	4.67	No	No	0	3	5
238	R:R:P321	R:R:Q320	7.9	No	No	0	4	3
239	R:R:I250	R:R:N215	2.83	Yes	Yes	0	8	9
240	R:R:L222	R:R:M243	2.83	No	No	0	8	8
241	R:R:L282	R:R:M276	2.83	No	No	0	4	1
242	R:R:G69	R:R:W157	2.81	No	Yes	0	7	7
243	R:R:P260	R:R:Y293	2.78	No	No	0	9	7
244	R:R:L310	R:R:L44	2.77	No	No	0	8	5
245	R:R:A160	R:R:F114	2.77	No	No	0	7	7
246	R:R:L163	R:R:L203	2.77	Yes	No	2	6	5
247	R:R:L166	R:R:L169	2.77	No	No	0	8	4
248	R:R:L199	R:R:L203	2.77	No	No	2	4	5
249	R:R:L210	R:R:L214	2.77	No	Yes	0	6	7
250	R:R:E21	R:R:I25	2.73	Yes	Yes	0	2	3
251	R:R:P179	R:R:W182	2.7	No	Yes	0	8	7
252	R:R:E287	R:R:L282	2.65	No	No	0	3	4
253	R:R:F34	R:R:S33	2.64	No	No	0	8	4
254	R:R:F115	R:R:V111	2.62	Yes	No	0	7	5
255	R:R:S218	R:R:Y131	2.54	No	Yes	0	9	7
256	R:R:F200	R:R:I265	2.51	No	No	0	8	7
257	R:R:F75	R:R:L76	2.44	Yes	No	0	7	6
258	R:R:F115	R:R:L76	2.44	Yes	No	0	7	6
259	R:R:Q234	R:R:R235	2.34	No	No	0	4	7
260	R:R:M108	R:R:W95	2.33	No	Yes	0	6	6
261	R:R:M108	R:R:W182	2.33	No	Yes	0	6	7
262	R:R:L303	R:R:W299	2.28	No	No	0	7	4
263	R:R:F34	R:R:R295	2.14	No	Yes	0	8	8
264	R:R:G55	R:R:G56	2.11	No	No	0	3	5
265	R:R:G204	R:R:G205	2.11	No	No	0	7	5
266	R:R:A50	R:R:G51	1.95	No	No	0	3	7
267	R:R:A195	R:R:G192	1.95	No	No	0	5	1
268	R:R:P273	R:R:P274	1.95	No	No	0	1	1
269	R:R:G192	R:R:S191	1.86	No	No	0	1	2
270	R:R:G38	R:R:V37	1.84	No	No	0	9	6
271	R:R:G180	R:R:V176	1.84	No	No	0	5	4
272	R:R:G197	R:R:V269	1.84	No	No	0	6	5
273	R:R:G205	R:R:V208	1.84	No	No	0	5	7
274	R:R:G209	R:R:V208	1.84	No	No	0	3	7
275	R:R:G197	R:R:I265	1.76	No	No	0	6	7
276	R:R:G123	R:R:M126	1.75	No	Yes	0	8	9
277	R:R:A124	R:R:S211	1.71	No	No	0	6	8
278	R:R:G249	R:R:L248	1.71	No	No	0	5	6
279	R:R:A32	R:R:V86	1.7	No	No	0	5	7
280	R:R:A97	R:R:V98	1.7	No	No	0	4	5
281	R:R:D193	R:R:G188	1.68	No	No	0	4	4
282	R:R:A275	R:R:T268	1.68	No	No	0	1	6
283	R:R:G51	R:R:Q54	1.64	No	No	0	7	5
284	R:R:S47	R:R:V48	1.62	No	No	0	4	8
285	R:R:S255	R:R:V256	1.62	No	No	0	5	6
286	R:R:V111	R:R:V80	1.6	No	No	0	5	6
287	R:R:V252	R:R:V256	1.6	No	No	0	5	6
288	R:R:T221	R:R:V225	1.59	No	No	0	7	7
289	R:R:A52	R:R:L64	1.58	No	No	0	6	7
290	R:R:C257	R:R:N300	1.57	No	Yes	0	9	9
291	R:R:I134	R:R:S218	1.55	No	No	0	8	9
292	R:R:L214	R:R:S128	1.5	Yes	No	0	7	6
293	R:R:L262	R:R:S201	1.5	No	No	0	8	7
294	R:R:I25	R:R:I292	1.47	Yes	No	0	3	4
295	R:R:L79	R:R:T83	1.47	No	No	0	6	8
296	R:R:P137	R:R:R136	1.44	No	No	0	8	5
297	R:R:E20	R:R:T18	1.41	No	No	0	3	8
298	R:R:L39	R:R:L79	1.38	No	No	0	6	6
299	R:R:R136	R:R:S139	1.32	No	No	0	5	4
300	R:R:R147	R:R:S145	1.32	No	No	0	5	7
301	R:R:D238	R:R:E242	1.3	No	No	0	5	8
302	R:R:R284	R:R:T15	1.29	Yes	No	0	1	4
303	R:R:R60	R:R:T59	1.29	Yes	No	0	6	7
304	R:R:F212	R:R:L213	1.22	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.46917	12	1	0
2	R:R:F12	13.6875	4	4	3
3	R:R:E21	7.3275	4	5	2
4	R:R:I25	3.73	4	0	3
5	R:R:L49	5.21	4	3	8
6	R:R:H58	6.7475	4	0	5
7	R:R:R60	3.855	4	6	6
8	R:R:F66	4.5775	4	0	7
9	R:R:L70	3.9525	4	1	9
10	R:R:D74	5.152	5	1	9
11	R:R:F75	4.618	5	0	7
12	R:R:H89	8.07	4	0	7
13	R:R:W95	7.572	5	4	6
14	R:R:I113	3.9875	4	0	7
15	R:R:F115	6.47	5	0	7
16	R:R:S118	4.475	4	1	7
17	R:R:M126	4.616	5	0	9
18	R:R:R130	5.25	4	1	9
19	R:R:Y131	5.43667	6	0	7
20	R:R:V153	4.6625	4	0	7
21	R:R:W157	6.366	5	1	7
22	R:R:L163	4.0275	4	2	6
23	R:R:P167	8.535	4	2	9
24	R:R:Y174	7.72	5	2	6
25	R:R:Y178	12.5175	4	5	3
26	R:R:W182	6.48286	7	1	7
27	R:R:F184	6.08	4	0	8
28	R:R:F196	5.98	5	2	7
29	R:R:L214	3.0275	4	0	7
30	R:R:N215	4.26	4	0	9
31	R:R:Y226	14.135	4	10	6
32	R:R:R237	18.7625	4	10	5
33	R:R:E240	5.7375	4	10	8
34	R:R:I250	4.8325	4	1	8
35	R:R:W258	8.692	5	1	8
36	R:R:F264	5.6525	4	0	4
37	R:R:R284	8.25	4	5	1
38	R:R:R295	10.7775	4	0	8
39	R:R:N300	8.455	4	1	9
40	R:R:Q301	6.97	5	1	9
41	R:R:D304	6.4325	4	1	9
42	R:R:Y308	6.06333	6	1	9
43	R:R:I309	4.412	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M112	32.4715	3.99	Yes	No	0	0	8
2	R:R:F184	R:R:M112	31.672	6.22	Yes	No	0	8	8
3	R:R:F184	R:R:I113	46.7873	3.77	Yes	Yes	0	8	7
4	R:R:I113	R:R:Y174	27.5187	3.63	Yes	Yes	0	7	6
5	R:R:V110	R:R:Y174	18.5138	5.05	No	Yes	0	6	6
6	R:R:L168	R:R:V110	13.0026	2.98	No	No	0	5	6
7	R:R:L168	R:R:R106	11.1565	3.64	No	No	0	5	5
8	L:L:?1	R:R:W182	82.6243	8.84	Yes	Yes	1	0	7
9	R:R:F184	R:R:W182	36.6715	7.02	Yes	Yes	0	8	7
10	R:R:M108	R:R:W182	13.8177	2.33	No	Yes	0	6	7
11	R:R:M108	R:R:W95	11.9638	2.33	No	Yes	0	6	6
12	R:R:P179	R:R:W182	37.5411	2.7	No	Yes	0	8	7
13	R:R:P179	R:R:Y178	35.7514	16.69	No	Yes	0	8	3
14	R:R:E287	R:R:Y178	16.1035	11.22	No	Yes	5	3	3
15	R:R:E287	R:R:L282	15.6989	2.65	No	No	0	3	4
16	R:R:L282	R:R:M276	10.5534	2.83	No	No	0	4	1
17	L:L:?1	R:R:H89	12.2206	4.54	Yes	Yes	0	0	7
18	R:R:E21	R:R:Y178	17.899	6.73	Yes	Yes	5	2	3
19	R:R:E21	R:R:I25	14.5356	2.73	Yes	Yes	0	2	3
20	R:R:I25	R:R:R295	11.532	5.01	Yes	Yes	0	3	8
21	L:L:?1	R:R:Q301	100	8.46	Yes	Yes	1	0	9
22	R:R:D74	R:R:Q301	63.7389	10.44	Yes	Yes	1	9	9
23	R:R:D74	R:R:N42	10.7519	4.04	Yes	No	0	9	9
24	L:L:?1	R:R:W258	33.2983	7.24	Yes	Yes	1	0	8
25	R:R:N300	R:R:W258	30.8978	13.56	Yes	Yes	1	9	8
26	R:R:D304	R:R:N300	58.2667	10.77	Yes	Yes	1	9	9
27	R:R:D304	R:R:Y308	86.6589	6.9	Yes	Yes	1	9	9
28	R:R:M126	R:R:Y308	38.0877	8.38	Yes	Yes	0	9	9
29	R:R:L67	R:R:M126	28.7929	4.24	No	Yes	0	8	9
30	R:R:I309	R:R:L67	14.874	5.71	Yes	No	3	9	8
31	R:R:N300	R:R:Q301	28.4291	7.92	Yes	Yes	1	9	9
32	R:R:D304	R:R:D74	29.4699	3.99	Yes	Yes	1	9	9
33	R:R:D74	R:R:L70	29.8142	4.07	Yes	Yes	1	9	9
34	R:R:L70	R:R:Y308	30.6507	3.52	Yes	Yes	1	9	9
35	R:R:R130	R:R:Y308	11.1448	4.12	Yes	Yes	1	9	9
36	R:R:L49	R:R:L67	12.4774	4.15	Yes	No	3	8	8
37	R:R:C68	R:R:L49	13.3761	7.94	No	Yes	0	5	8
38	R:R:C68	R:R:L64	11.5028	3.17	No	No	0	5	7
39	R:R:I250	R:R:Y308	73.1563	9.67	Yes	Yes	1	8	9
40	R:R:I250	R:R:N215	72.7653	2.83	Yes	Yes	0	8	9
41	R:R:A127	R:R:N215	33.0474	3.13	No	Yes	0	9	9
42	R:R:A127	R:R:L214	28.4311	3.15	No	Yes	0	9	7
43	R:R:L214	R:R:Y131	23.7798	4.69	Yes	Yes	0	7	7
44	R:R:L132	R:R:Y131	11.2051	3.52	No	Yes	0	6	7
45	R:R:Q88	R:R:S181	10.071	5.78	No	No	0	6	8
46	R:R:F200	R:R:I113	16.6832	5.02	No	Yes	0	8	7
47	R:R:F184	R:R:L185	19.7899	7.31	Yes	No	0	8	5
48	R:R:F196	R:R:L185	18.0119	8.53	Yes	No	0	7	5
49	R:R:F200	R:R:I265	14.8449	2.51	No	No	0	8	7
50	R:R:L247	R:R:N215	34.3255	6.87	No	Yes	0	8	9
51	R:R:L247	R:R:M243	28.1743	4.24	No	No	0	8	8
52	R:R:L222	R:R:M243	26.7075	2.83	No	No	0	8	8
53	R:R:E240	R:R:L222	17.4263	6.63	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A31	6.67	1	Yes	No	0	7	0	1
L:L:?1	R:R:L78	6.84	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	11.44	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	10.52	1	Yes	No	0	8	0	1
L:L:?1	R:R:H89	4.54	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M112	3.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	4.83	1	Yes	No	0	7	0	1
L:L:?1	R:R:W182	8.84	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:W258	7.24	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L294	5.86	1	Yes	No	0	7	0	1
L:L:?1	R:R:T298	10.4	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q301	8.46	1	Yes	Yes	0	9	0	1
R:R:H89	R:R:R22	4.51	0	Yes	No	7	1	1	2
R:R:H89	R:R:P28	10.68	0	Yes	No	7	6	1	2
R:R:D74	R:R:P119	3.22	1	Yes	No	9	8	2	2
R:R:D74	R:R:Q301	10.44	1	Yes	Yes	9	9	2	1
R:R:S181	R:R:V85	4.85	0	No	No	8	8	2	1
R:R:H89	R:R:S181	12.55	0	Yes	No	7	8	1	2
R:R:F184	R:R:M112	6.22	0	Yes	No	8	8	2	1
R:R:P119	R:R:Q301	4.74	1	No	Yes	8	9	2	1
R:R:L120	R:R:W258	14.81	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	14.24	0	No	Yes	7	7	2	1
R:R:F184	R:R:W182	7.02	0	Yes	Yes	8	7	2	1
R:R:L290	R:R:W182	5.69	0	No	Yes	6	7	2	1
R:R:L294	R:R:W182	4.56	1	No	Yes	7	7	1	1
R:R:L262	R:R:W258	4.56	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	13.56	1	Yes	Yes	9	8	2	1
R:R:Q301	R:R:W258	3.29	1	Yes	Yes	9	8	1	1
R:R:N300	R:R:Q301	7.92	1	Yes	Yes	9	9	2	1
R:R:P179	R:R:W182	2.7	0	No	Yes	8	7	2	1
R:R:M108	R:R:W182	2.33	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GGG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	273
Number of Links	304
Number of Hubs	43
Number of Links mediated by Hubs	157
Number of Communities	10
Number of Nodes involved in Communities	53
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	88274
Length Of Smallest Path	3
Average Path Length	13.8558
Length of Longest Path	28
Minimum Path Strength	1.38
Average Path Strength	6.26052
Maximum Path Strength	30.895
Minimum Path Correlation	0.7
Average Path Correlation	0.926666
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.0037
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	59.4149
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • response to ketone • response to lipid • response to oxygen-containing compound • response to testosterone • regulation of blood pressure • positive regulation of blood pressure • smooth muscle contraction • muscle contraction • muscle system process • cellular response to stimulus • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • response to external stimulus • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • response to biotic stimulus • cellular response to biotic stimulus • cellular response to chemical stimulus • response to bacterium • cellular response to lipid • cellular process • response to external biotic stimulus • response to molecule of bacterial origin • response to alcohol • response to ethanol • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of locomotion • regulation of cell motility • cell migration involved in sprouting angiogenesis • regulation of blood vessel endothelial cell migration • endothelial cell migration • negative regulation of biological process • negative regulation of endothelial cell migration • negative regulation of blood vessel endothelial cell migration • regulation of cell migration • negative regulation of cellular process • regulation of endothelial cell migration • blood vessel endothelial cell migration • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of cell migration involved in sprouting angiogenesis • sprouting angiogenesis • regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of smooth muscle contraction • regulation of muscle system process • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of body fluid levels • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • response to stress • regulation of response to stress • coagulation • positive regulation of hemostasis • response to wounding • regulation of hemostasis • positive regulation of response to wounding • wound healing • regulation of blood coagulation • hemostasis • blood coagulation • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • defense response • inflammatory response • response to nutrient levels • response to nutrient • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cell periphery • plasma membrane • membrane • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1I
Name	N-(cyclopent-3-ene-1-carbonyl)-L-histidine
Synonyms
Identifier
Formula	C12 H15 N3 O3
Molecular Weight	249.266
SMILES
PubChem	64766902
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	1
Total Bonds	34
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>9GGG_nogp_Chain_R P C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IIU	A	Lipid	Prostanoid	TXA2	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	6IIV	A	Lipid	Prostanoid	TXA2	Homo sapiens	Daltroban	-	-	3	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	8XJN	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	9GG5	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2025-08-27	To be published
	9GG5 (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.26	2025-08-27	To be published
	9GGG	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-08-27	To be published
	9GGG (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-		3.25	2025-08-27	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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