psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C102	R:R:C11	7.28	No	No	0	2	4
2	R:R:C105	R:R:C11	3.64	No	No	0	9	4
3	R:R:P14	R:R:R13	4.32	No	No	3	3	4
4	R:R:Q281	R:R:R13	15.19	No	No	3	4	4
5	R:R:E287	R:R:R13	5.82	No	No	0	3	4
6	R:R:P14	R:R:Q281	11.05	No	No	3	3	4
7	R:R:I17	R:R:T15	4.56	No	No	0	3	4
8	R:R:I17	R:R:Y178	9.67	No	Yes	0	3	3
9	R:R:E20	R:R:T18	5.64	No	No	0	3	8
10	R:R:R284	R:R:T18	6.47	No	No	0	1	8
11	R:R:E21	R:R:I25	9.56	No	No	4	2	3
12	R:R:E21	R:R:K288	14.85	No	No	4	2	1
13	R:R:R22	R:R:R23	10.66	No	No	0	1	1
14	R:R:F93	R:R:R22	4.28	No	No	0	3	1
15	R:R:P28	R:R:R23	11.53	No	No	0	6	1
16	R:R:I25	R:R:K288	10.18	No	No	4	3	1
17	R:R:A26	R:R:P179	3.74	No	No	0	4	8
18	R:R:F30	R:R:S27	3.96	No	No	0	5	7
19	R:R:P28	R:R:W29	5.4	No	No	0	6	3
20	R:R:H89	R:R:P28	4.58	No	No	0	7	6
21	R:R:F30	R:R:F34	4.29	No	No	0	5	8
22	R:R:F30	R:R:R295	23.52	No	No	0	5	8
23	L:L:?1	R:R:A31	6.67	Yes	No	0	0	7
24	R:R:F34	R:R:T298	5.19	No	No	0	8	8
25	R:R:F34	R:R:W299	12.03	No	No	0	8	4
26	L:L:?1	R:R:C35	5.6	Yes	No	0	0	6
27	R:R:G38	R:R:I302	7.05	No	No	0	9	9
28	R:R:F75	R:R:L39	4.87	Yes	No	0	7	6
29	R:R:S41	R:R:W306	8.65	No	No	0	9	8
30	R:R:D74	R:R:N42	6.73	Yes	No	0	9	9
31	R:R:F75	R:R:N42	3.62	Yes	No	0	7	9
32	R:R:N42	R:R:P305	11.4	No	No	0	9	9
33	R:R:F75	R:R:L43	8.53	Yes	No	0	7	5
34	R:R:A45	R:R:I309	4.87	No	No	0	9	9
35	R:R:A45	R:R:L310	4.73	No	No	0	9	8
36	R:R:L46	R:R:L49	4.15	No	Yes	0	7	8
37	R:R:L46	R:R:V71	7.45	No	No	0	7	8
38	R:R:V315	R:R:V48	4.81	No	No	0	7	8
39	R:R:L49	R:R:L67	4.15	Yes	Yes	1	8	8
40	R:R:H58	R:R:S57	6.97	No	No	0	5	5
41	R:R:F66	R:R:S62	6.61	Yes	No	0	7	6
42	R:R:E129	R:R:S62	7.19	No	No	0	9	6
43	R:R:F63	R:R:L67	6.09	No	Yes	1	8	8
44	R:R:F63	R:R:M126	4.98	No	Yes	1	8	9
45	R:R:F63	R:R:R130	10.69	No	Yes	1	8	9
46	R:R:Q146	R:R:T65	5.67	No	No	0	5	6
47	R:R:A149	R:R:T65	5.03	No	No	0	7	6
48	R:R:T65	R:R:W150	8.49	No	No	0	6	4
49	R:R:F66	R:R:M126	4.98	Yes	Yes	0	7	9
50	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
51	R:R:F66	R:R:V153	3.93	Yes	No	0	7	7
52	R:R:L67	R:R:M126	4.24	Yes	Yes	1	8	9
53	R:R:L67	R:R:Y308	3.52	Yes	Yes	1	8	9
54	R:R:I309	R:R:L67	8.56	No	Yes	0	9	8
55	R:R:D74	R:R:L70	8.14	Yes	Yes	1	9	9
56	R:R:L122	R:R:L70	4.15	No	Yes	0	7	9
57	R:R:D304	R:R:L70	8.14	Yes	Yes	1	9	9
58	R:R:L70	R:R:Y308	4.69	Yes	Yes	1	9	9
59	R:R:S118	R:R:T73	4.8	No	No	2	7	9
60	R:R:T73	R:R:W157	7.28	No	No	2	9	7
61	R:R:D74	R:R:P119	6.44	Yes	No	1	9	8
62	R:R:D74	R:R:Q301	9.14	Yes	Yes	1	9	9
63	R:R:D304	R:R:D74	6.65	Yes	Yes	1	9	9
64	R:R:F75	R:R:L76	3.65	Yes	No	0	7	6
65	R:R:F115	R:R:L76	3.65	No	No	0	7	6
66	R:R:F115	R:R:G77	7.53	No	No	0	7	8
67	R:R:L78	R:R:Q301	3.99	No	Yes	1	8	9
68	L:L:?1	R:R:L78	5.86	Yes	No	1	0	8
69	L:L:?1	R:R:T81	10.4	Yes	No	0	0	7
70	R:R:I84	R:R:M108	5.83	No	No	0	5	6
71	L:L:?1	R:R:V85	9.46	Yes	No	0	0	8
72	R:R:Q88	R:R:W95	15.33	No	Yes	0	6	6
73	R:R:H89	R:R:S181	8.37	No	No	1	7	8
74	L:L:?1	R:R:H89	9.07	Yes	No	1	0	7
75	R:R:L92	R:R:V98	17.88	No	No	0	4	5
76	R:R:E94	R:R:H96	4.92	No	No	0	4	2
77	R:R:L104	R:R:W95	10.25	No	Yes	0	6	6
78	R:R:C105	R:R:W95	3.92	No	Yes	0	9	6
79	R:R:V176	R:R:W95	3.68	No	Yes	0	4	6
80	R:R:D99	R:R:L104	6.79	Yes	No	0	5	6
81	R:R:C105	R:R:C183	7.28	No	No	0	9	9
82	R:R:L168	R:R:R106	6.07	No	No	0	5	5
83	R:R:M108	R:R:M112	5.78	No	No	0	6	8
84	R:R:G109	R:R:Y174	11.59	No	Yes	0	8	6
85	R:R:F184	R:R:M112	4.98	Yes	No	0	8	8
86	L:L:?1	R:R:M112	5.99	Yes	No	0	0	8
87	R:R:G164	R:R:I113	3.53	No	Yes	0	7	7
88	R:R:I113	R:R:Y174	4.84	Yes	Yes	0	7	6
89	R:R:F184	R:R:I113	3.77	Yes	Yes	0	8	7
90	R:R:F200	R:R:I113	6.28	No	Yes	0	8	7
91	R:R:F114	R:R:F115	10.72	Yes	No	0	7	7
92	R:R:F114	R:R:S118	7.93	Yes	No	2	7	7
93	R:R:F114	R:R:W157	8.02	Yes	No	2	7	7
94	R:R:F114	R:R:L161	7.31	Yes	No	0	7	4
95	L:L:?1	R:R:G116	6.03	Yes	No	0	0	7
96	R:R:L117	R:R:L121	4.15	No	No	0	7	6
97	R:R:L117	R:R:L203	4.15	No	No	0	7	5
98	R:R:S118	R:R:W157	4.94	No	No	2	7	7
99	R:R:P119	R:R:Q301	7.9	No	Yes	1	8	9
100	R:R:L120	R:R:W258	13.67	No	Yes	0	8	8
101	R:R:L121	R:R:V156	5.96	No	No	0	6	6
102	R:R:L121	R:R:S207	4.5	No	No	0	6	7
103	R:R:L122	R:R:V156	5.96	No	No	0	7	6
104	R:R:A124	R:R:L210	4.73	No	No	0	6	6
105	R:R:M126	R:R:Y308	10.78	Yes	Yes	1	9	9
106	R:R:E129	R:R:R140	16.28	No	Yes	0	9	8
107	R:R:M243	R:R:R130	3.72	No	Yes	1	8	9
108	R:R:Q246	R:R:R130	15.19	No	Yes	0	8	9
109	R:R:L247	R:R:R130	4.86	Yes	Yes	1	8	9
110	R:R:L132	R:R:Y131	3.52	No	Yes	0	6	7
111	R:R:T135	R:R:Y131	14.98	No	Yes	0	7	7
112	R:R:L214	R:R:Y131	3.52	Yes	Yes	0	7	7
113	R:R:V217	R:R:Y131	7.57	No	Yes	0	5	7
114	R:R:S218	R:R:Y131	3.82	No	Yes	0	9	7
115	R:R:L132	R:R:R136	6.07	No	No	0	6	5
116	R:R:L132	R:R:R140	13.36	No	Yes	0	6	8
117	R:R:I134	R:R:L222	5.71	No	No	0	8	8
118	R:R:R136	R:R:S139	5.27	No	No	0	5	4
119	R:R:R147	R:R:R148	8.53	No	No	0	5	5
120	R:R:V153	R:R:W150	4.9	No	No	0	7	4
121	R:R:F196	R:R:L163	4.87	Yes	No	0	7	6
122	R:R:F196	R:R:L166	4.87	Yes	No	0	7	8
123	R:R:P167	R:R:Y174	22.25	No	Yes	0	9	6
124	R:R:F196	R:R:P167	8.67	Yes	No	0	7	9
125	R:R:R173	R:R:T186	16.82	No	No	0	3	4
126	R:R:E190	R:R:R173	9.3	No	No	5	1	3
127	R:R:D193	R:R:R173	5.96	No	No	5	4	3
128	R:R:T175	R:R:T186	7.85	No	No	0	3	4
129	R:R:Q177	R:R:W182	9.86	No	Yes	0	7	7
130	R:R:P179	R:R:Y178	11.13	No	Yes	0	8	3
131	R:R:R284	R:R:Y178	15.43	No	Yes	0	1	3
132	R:R:E287	R:R:Y178	10.1	No	Yes	0	3	3
133	R:R:P179	R:R:S181	3.56	No	No	0	8	8
134	L:L:?1	R:R:S181	5.3	Yes	No	1	0	8
135	R:R:F184	R:R:W182	7.02	Yes	Yes	0	8	7
136	R:R:L294	R:R:W182	6.83	No	Yes	1	7	7
137	L:L:?1	R:R:W182	12.86	Yes	Yes	1	0	7
138	R:R:F184	R:R:L185	12.18	Yes	No	0	8	5
139	R:R:F196	R:R:L185	8.53	Yes	No	0	7	5
140	R:R:F200	R:R:L185	3.65	No	No	0	8	5
141	R:R:L187	R:R:T268	5.9	No	No	0	6	6
142	R:R:D193	R:R:G188	5.03	No	No	0	4	4
143	R:R:A189	R:R:P274	3.74	No	No	0	3	1
144	R:R:D193	R:R:E190	10.39	No	No	5	4	1
145	R:R:L198	R:R:L270	4.15	No	No	0	4	3
146	R:R:G204	R:R:S207	3.71	No	No	0	7	7
147	R:R:L259	R:R:V208	4.47	No	No	0	6	7
148	R:R:L210	R:R:L214	5.54	No	Yes	0	6	7
149	R:R:F212	R:R:T216	3.89	No	No	0	5	5
150	R:R:F212	R:R:M251	7.46	No	No	0	5	8
151	R:R:F212	R:R:S255	3.96	No	No	0	5	5
152	R:R:L247	R:R:N215	5.49	Yes	No	0	8	9
153	R:R:I250	R:R:N215	4.25	No	No	0	8	9
154	R:R:L247	R:R:V219	4.47	Yes	No	0	8	7
155	R:R:L222	R:R:M244	4.24	No	No	0	8	6
156	R:R:C223	R:R:M244	4.86	No	No	0	4	6
157	R:R:E240	R:R:V225	8.56	No	No	0	8	7
158	R:R:R237	R:R:Y226	17.49	No	Yes	0	5	6
159	R:R:V241	R:R:Y226	5.05	No	Yes	0	4	6
160	R:R:M244	R:R:Y226	3.59	No	Yes	0	6	6
161	R:R:E230	R:R:Q229	3.82	No	No	0	3	4
162	R:R:E240	R:R:R235	6.98	No	No	0	8	7
163	R:R:E242	R:R:R312	6.98	No	No	0	8	9
164	R:R:E242	R:R:R313	6.98	No	No	0	8	6
165	R:R:L247	R:R:M243	4.24	Yes	No	1	8	8
166	R:R:Q246	R:R:R312	26.87	No	No	0	8	9
167	R:R:I250	R:R:V307	4.61	No	Yes	0	8	8
168	R:R:I250	R:R:Y308	14.51	No	Yes	0	8	9
169	R:R:L303	R:R:V253	8.94	No	No	0	7	7
170	R:R:C257	R:R:N300	6.3	No	Yes	0	9	9
171	R:R:A297	R:R:W258	7.78	No	Yes	0	8	8
172	R:R:N300	R:R:W258	12.43	Yes	Yes	1	9	8
173	R:R:Q301	R:R:W258	6.57	Yes	Yes	1	9	8
174	L:L:?1	R:R:W258	4.82	Yes	Yes	1	0	8
175	R:R:Q267	R:R:V263	4.3	No	No	0	4	6
176	R:R:F264	R:R:T268	7.78	Yes	No	0	4	6
177	R:R:E289	R:R:F264	8.16	No	Yes	0	1	4
178	R:R:F264	R:R:L290	7.31	Yes	No	0	4	6
179	R:R:F264	R:R:Y293	9.28	Yes	No	0	4	7
180	R:R:A275	R:R:R271	5.53	No	No	0	1	3
181	R:R:L282	R:R:M276	7.07	No	No	0	4	1
182	R:R:E287	R:R:L282	5.3	No	No	0	3	4
183	R:R:S283	R:R:T286	4.8	No	No	0	1	2
184	R:R:L291	R:R:R295	12.15	No	No	0	7	8
185	L:L:?1	R:R:L294	7.81	Yes	No	1	0	7
186	L:L:?1	R:R:R295	4.29	Yes	No	0	0	8
187	L:L:?1	R:R:T298	10.4	Yes	No	0	0	8
188	R:R:I302	R:R:W299	12.92	No	No	0	9	4
189	R:R:N300	R:R:Q301	6.6	Yes	Yes	1	9	9
190	R:R:D304	R:R:N300	9.42	Yes	Yes	1	9	9
191	L:L:?1	R:R:Q301	4.7	Yes	Yes	1	0	9
192	R:R:D304	R:R:Y308	6.9	Yes	Yes	1	9	9
193	R:R:L310	R:R:W306	14.81	No	No	0	8	8
194	R:R:F311	R:R:W306	7.02	No	No	0	7	8
195	R:R:F311	R:R:V307	3.93	No	Yes	0	7	8
196	R:R:L316	R:R:R313	7.29	No	No	0	7	6
197	R:R:Q146	R:R:R53	3.5	No	No	0	5	6
198	R:R:G280	R:R:M276	3.49	No	No	0	5	1
199	R:R:A266	R:R:S201	3.42	No	No	0	5	7
200	R:R:G204	R:R:L262	3.42	No	No	0	7	8
201	R:R:C183	R:R:M108	3.24	No	No	0	9	6
202	R:R:S255	R:R:V208	3.23	No	No	0	5	7
203	R:R:D99	R:R:P100	3.22	Yes	No	0	5	4
204	R:R:V111	R:R:V80	3.21	No	No	0	5	6
205	R:R:V194	R:R:V269	3.21	No	No	0	3	5
206	R:R:V253	R:R:V307	3.21	No	Yes	0	7	8
207	R:R:S283	R:R:T285	3.2	No	No	0	1	1
208	R:R:C68	R:R:L72	3.17	No	No	0	5	5
209	R:R:T81	R:R:V111	3.17	No	No	0	7	5
210	R:R:A160	R:R:L117	3.15	No	No	0	7	7
211	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
212	R:R:I134	R:R:T221	3.04	No	No	0	8	7
213	R:R:M276	R:R:T186	3.01	No	No	0	1	4
214	R:R:L214	R:R:S128	3	Yes	No	0	7	6
215	R:R:L165	R:R:V110	2.98	No	No	0	5	6
216	R:R:L168	R:R:V110	2.98	No	No	0	5	6
217	R:R:L120	R:R:V208	2.98	No	No	0	8	7
218	R:R:Q281	R:R:S277	2.89	No	No	0	4	2
219	R:R:P141	R:R:R140	2.88	No	Yes	0	5	8
220	R:R:I265	R:R:L187	2.85	Yes	No	0	7	6
221	R:R:I265	R:R:L261	2.85	Yes	No	0	7	7
222	R:R:L222	R:R:M243	2.83	No	No	0	8	8
223	R:R:L248	R:R:M251	2.83	No	No	0	6	8
224	R:R:E21	R:R:T18	2.82	No	No	0	2	8
225	R:R:P260	R:R:Y293	2.78	No	No	0	9	7
226	R:R:L39	R:R:L79	2.77	No	No	0	6	6
227	R:R:L310	R:R:L44	2.77	No	No	0	8	5
228	R:R:A142	R:R:R60	2.77	No	No	0	5	6
229	R:R:A125	R:R:F66	2.77	No	Yes	0	6	7
230	R:R:L163	R:R:L199	2.77	No	No	0	6	4
231	R:R:L199	R:R:L203	2.77	No	No	0	4	5
232	R:R:A232	R:R:R237	2.77	No	No	0	4	5
233	R:R:L290	R:R:Q177	2.66	No	No	0	6	7
234	R:R:F107	R:R:V80	2.62	No	No	0	6	6
235	R:R:R312	R:R:V315	2.62	No	No	0	9	7
236	R:R:F264	R:R:T286	2.59	Yes	No	0	4	2
237	R:R:H58	R:R:L64	2.57	No	No	0	5	7
238	R:R:V37	R:R:W299	2.45	No	No	0	6	4
239	L:L:?1	R:R:G82	2.41	Yes	No	0	0	8
240	R:R:L168	R:R:Y174	2.34	No	Yes	0	5	6
241	R:R:Q234	R:R:R235	2.34	No	No	0	4	7
242	R:R:E94	R:R:F93	2.33	No	No	0	4	3
243	R:R:G55	R:R:G56	2.11	No	No	0	3	5
244	R:R:G204	R:R:G205	2.11	No	No	0	7	5
245	R:R:G172	R:R:P167	2.03	No	No	0	8	9
246	R:R:C68	R:R:G69	1.96	No	No	0	5	7
247	R:R:A50	R:R:G51	1.95	No	No	0	3	7
248	R:R:A195	R:R:G192	1.95	No	No	0	5	1
249	R:R:P273	R:R:P274	1.95	No	No	0	1	1
250	R:R:G123	R:R:S211	1.86	No	No	0	8	8
251	R:R:G192	R:R:S191	1.86	No	No	0	1	2
252	R:R:G180	R:R:V176	1.84	No	No	0	5	4
253	R:R:G249	R:R:V307	1.84	No	Yes	0	5	8
254	R:R:P278	R:R:S277	1.78	No	No	0	7	2
255	R:R:G197	R:R:I265	1.76	No	Yes	0	6	7
256	R:R:A144	R:R:S62	1.71	No	No	0	5	6
257	R:R:A124	R:R:S211	1.71	No	No	0	6	8
258	R:R:A127	R:R:S211	1.71	No	No	0	9	8
259	R:R:A279	R:R:S277	1.71	No	No	0	1	2
260	R:R:A32	R:R:V86	1.7	No	No	0	5	7
261	R:R:A195	R:R:V171	1.7	No	No	0	5	4
262	R:R:A231	R:R:V225	1.7	No	No	0	3	7
263	R:R:D99	R:R:G101	1.68	Yes	No	0	5	3
264	R:R:A275	R:R:T268	1.68	No	No	0	1	6
265	R:R:D238	R:R:P236	1.61	No	No	0	5	3
266	R:R:V252	R:R:V256	1.6	No	No	0	5	6
267	R:R:C68	R:R:L49	1.59	No	Yes	0	5	8
268	R:R:A266	R:R:L198	1.58	No	No	0	5	4
269	R:R:A254	R:R:N300	1.56	No	Yes	0	8	9
270	R:R:I265	R:R:V269	1.54	Yes	No	0	7	5
271	R:R:A50	R:R:Q54	1.52	No	No	0	3	5
272	R:R:I84	R:R:T83	1.52	No	No	0	5	8
273	R:R:A97	R:R:E94	1.51	No	No	0	4	4
274	R:R:G133	R:R:R140	1.5	No	Yes	0	8	8
275	R:R:L262	R:R:S201	1.5	No	No	0	8	7
276	R:R:L166	R:R:V171	1.49	No	No	0	8	4
277	R:R:L213	R:R:T216	1.47	No	No	0	4	5
278	R:R:D238	R:R:S239	1.47	No	No	0	5	6
279	R:R:E129	R:R:S61	1.44	No	No	0	9	7
280	R:R:P137	R:R:R136	1.44	No	No	0	8	5
281	R:R:P236	R:R:R235	1.44	No	No	0	3	7
282	R:R:I25	R:R:L24	1.43	No	No	0	3	1
283	R:R:Q146	R:R:T59	1.42	No	No	0	5	7
284	R:R:L49	R:R:L64	1.38	Yes	No	1	8	7
285	R:R:A52	R:R:R318	1.38	No	No	0	6	6
286	R:R:L64	R:R:L67	1.38	No	Yes	1	7	8
287	R:R:E20	R:R:L19	1.33	No	No	0	3	3
288	R:R:R148	R:R:S145	1.32	No	No	0	5	7
289	R:R:Q229	R:R:Q233	1.28	No	No	0	4	4
290	R:R:I292	R:R:Y293	1.21	No	No	0	4	7
291	R:R:D99	R:R:R103	1.19	Yes	No	0	5	2
292	R:R:Q320	R:R:R317	1.17	No	No	0	3	5
293	R:R:F12	R:R:H96	1.13	No	No	0	3	2
294	R:R:E240	R:R:Y226	1.12	No	Yes	0	8	6
295	R:R:H227	R:R:Y226	1.09	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L49	2.8175	4	1	8
2	R:R:F66	4.956	5	0	7
3	R:R:L67	4.65667	6	1	8
4	R:R:L70	6.28	4	1	9
5	R:R:D74	7.42	5	1	9
6	R:R:F75	5.1675	4	0	7
7	R:R:W95	8.295	4	0	6
8	R:R:D99	3.22	4	0	5
9	R:R:I113	4.605	4	0	7
10	R:R:F114	8.495	4	2	7
11	R:R:M126	6.245	4	1	9
12	R:R:R130	8.615	4	1	9
13	R:R:Y131	6.682	5	0	7
14	R:R:R140	8.505	4	0	8
15	R:R:Y174	10.255	4	0	6
16	R:R:Y178	11.5825	4	0	3
17	R:R:W182	9.1425	4	1	7
18	R:R:F184	6.9875	4	0	8
19	R:R:F196	6.735	4	0	7
20	R:R:L214	3.8025	4	0	7
21	R:R:Y226	5.668	5	0	6
22	R:R:L247	4.765	4	1	8
23	R:R:W258	9.054	5	1	8
24	R:R:F264	7.024	5	0	4
25	R:R:I265	2.25	4	0	7
26	R:R:N300	7.262	5	1	9
27	R:R:Q301	6.48333	6	1	9
28	R:R:D304	7.7775	4	1	9
29	R:R:V307	3.3975	4	0	8
30	R:R:Y308	8.08	5	1	9
31	L:L:?1	6.97938	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C105	R:R:C183	14.169	7.28	No	No	0	9	9
2	R:R:C183	R:R:M108	15.3286	3.24	No	No	0	9	6
3	R:R:M108	R:R:M112	18.4186	5.78	No	No	0	6	8
4	L:L:?1	R:R:M112	41.4328	5.99	Yes	No	0	0	8
5	L:L:?1	R:R:S181	33.9276	5.3	Yes	No	1	0	8
6	R:R:P179	R:R:S181	33.4799	3.56	No	No	0	8	8
7	R:R:P179	R:R:Y178	31.246	11.13	No	Yes	0	8	3
8	R:R:E287	R:R:Y178	18.8942	10.1	No	Yes	0	3	3
9	L:L:?1	R:R:H89	11.2578	9.07	Yes	No	1	0	7
10	R:R:H89	R:R:P28	10.7445	4.58	No	No	0	7	6
11	L:L:?1	R:R:Q301	99.8261	4.7	Yes	Yes	1	0	9
12	R:R:D74	R:R:Q301	69.3576	9.14	Yes	Yes	1	9	9
13	R:R:D74	R:R:N42	11.0692	6.73	Yes	No	0	9	9
14	L:L:?1	R:R:W258	34.3098	4.82	Yes	Yes	1	0	8
15	R:R:N300	R:R:W258	34.4098	12.43	Yes	Yes	1	9	8
16	R:R:D304	R:R:N300	65.7952	9.42	Yes	Yes	1	9	9
17	R:R:D304	R:R:Y308	100	6.9	Yes	Yes	1	9	9
18	R:R:I250	R:R:Y308	31.7544	14.51	No	Yes	0	8	9
19	R:R:N300	R:R:Q301	32.1464	6.6	Yes	Yes	1	9	9
20	R:R:D304	R:R:D74	35.2561	6.65	Yes	Yes	1	9	9
21	R:R:D74	R:R:L70	37.9262	8.14	Yes	Yes	1	9	9
22	R:R:L70	R:R:Y308	38.6462	4.69	Yes	Yes	1	9	9
23	R:R:L67	R:R:Y308	43.6224	3.52	Yes	Yes	1	8	9
24	R:R:F63	R:R:L67	29.4944	6.09	No	Yes	1	8	8
25	R:R:F63	R:R:R130	57.711	10.69	No	Yes	1	8	9
26	R:R:Q246	R:R:R130	15.1154	15.19	No	Yes	0	8	9
27	R:R:Q246	R:R:R312	13.0603	26.87	No	No	0	8	9
28	R:R:M126	R:R:Y308	63.7057	10.78	Yes	Yes	1	9	9
29	R:R:F63	R:R:M126	30.2997	4.98	No	Yes	1	8	9
30	R:R:F66	R:R:M126	36.3976	4.98	Yes	Yes	0	7	9
31	R:R:F66	R:R:S62	25.5072	6.61	Yes	No	0	7	6
32	R:R:E129	R:R:S62	23.252	7.19	No	No	0	9	6
33	R:R:C105	R:R:W95	10.6706	3.92	No	Yes	0	9	6
34	R:R:F184	R:R:M112	24.4378	4.98	Yes	No	0	8	8
35	R:R:F184	R:R:I113	23.7506	3.77	Yes	Yes	0	8	7
36	R:R:I113	R:R:Y174	17.3394	4.84	Yes	Yes	0	7	6
37	R:R:F184	R:R:L185	22.6173	12.18	Yes	No	0	8	5
38	R:R:F196	R:R:L185	18.5498	8.53	Yes	No	0	7	5
39	R:R:L132	R:R:Y131	12.9521	3.52	No	Yes	0	6	7
40	R:R:L132	R:R:R140	17.5641	13.36	No	Yes	0	6	8
41	R:R:E129	R:R:R140	20.9887	16.28	No	Yes	0	9	8
42	R:R:M243	R:R:R130	40.9014	3.72	No	Yes	1	8	9
43	R:R:I250	R:R:N215	23.1864	4.25	No	No	0	8	9
44	R:R:L247	R:R:N215	22.0941	5.49	Yes	No	0	8	9
45	R:R:L247	R:R:M243	19.898	4.24	Yes	No	1	8	8
46	R:R:L222	R:R:M243	57.7356	2.83	No	No	0	8	8
47	R:R:F196	R:R:L166	11.02	4.87	Yes	No	0	7	8
48	R:R:E287	R:R:L282	10.7297	5.3	No	No	0	3	4
49	R:R:F184	R:R:W182	24.6133	7.02	Yes	Yes	0	8	7
50	R:R:Q177	R:R:W182	21.7612	9.86	No	Yes	0	7	7
51	L:L:?1	R:R:W182	44.4392	12.86	Yes	Yes	1	0	7
52	R:R:L290	R:R:Q177	20.6426	2.66	No	No	0	6	7
53	R:R:F264	R:R:L290	19.6733	7.31	Yes	No	0	4	6
54	R:R:F264	R:R:T268	10.6264	7.78	Yes	No	0	4	6
55	R:R:L222	R:R:M244	48.3459	4.24	No	No	0	8	6
56	R:R:M244	R:R:Y226	41.8445	3.59	No	Yes	0	6	6
57	R:R:E240	R:R:Y226	25.9812	1.12	No	Yes	0	8	6
58	R:R:E240	R:R:R235	16.1667	6.98	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H89	R:R:P28	4.58	1	No	No	7	6	1	2
R:R:F30	R:R:F34	4.29	0	No	No	5	8	2	2
R:R:F30	R:R:R295	23.52	0	No	No	5	8	2	1
L:L:?1	R:R:A31	6.67	1	Yes	No	0	7	0	1
R:R:F34	R:R:T298	5.19	0	No	No	8	8	2	1
L:L:?1	R:R:C35	5.6	1	Yes	No	0	6	0	1
R:R:D74	R:R:P119	6.44	1	Yes	No	9	8	2	2
R:R:D74	R:R:Q301	9.14	1	Yes	Yes	9	9	2	1
R:R:L78	R:R:Q301	3.99	1	No	Yes	8	9	1	1
L:L:?1	R:R:L78	5.86	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	10.4	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	9.46	1	Yes	No	0	8	0	1
R:R:H89	R:R:S181	8.37	1	No	No	7	8	1	1
L:L:?1	R:R:H89	9.07	1	Yes	No	0	7	0	1
R:R:M108	R:R:M112	5.78	0	No	No	6	8	2	1
R:R:F184	R:R:M112	4.98	0	Yes	No	8	8	2	1
L:L:?1	R:R:M112	5.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	6.03	1	Yes	No	0	7	0	1
R:R:P119	R:R:Q301	7.9	1	No	Yes	8	9	2	1
R:R:L120	R:R:W258	13.67	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	9.86	0	No	Yes	7	7	2	1
R:R:P179	R:R:S181	3.56	0	No	No	8	8	2	1
L:L:?1	R:R:S181	5.3	1	Yes	No	0	8	0	1
R:R:F184	R:R:W182	7.02	0	Yes	Yes	8	7	2	1
R:R:L294	R:R:W182	6.83	1	No	Yes	7	7	1	1
L:L:?1	R:R:W182	12.86	1	Yes	Yes	0	7	0	1
R:R:A297	R:R:W258	7.78	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	12.43	1	Yes	Yes	9	8	2	1
R:R:Q301	R:R:W258	6.57	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:W258	4.82	1	Yes	Yes	0	8	0	1
R:R:L291	R:R:R295	12.15	0	No	No	7	8	2	1
L:L:?1	R:R:L294	7.81	1	Yes	No	0	7	0	1
L:L:?1	R:R:R295	4.29	1	Yes	No	0	8	0	1
L:L:?1	R:R:T298	10.4	1	Yes	No	0	8	0	1
R:R:N300	R:R:Q301	6.6	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:Q301	4.7	1	Yes	Yes	0	9	0	1
R:R:T81	R:R:V111	3.17	0	No	No	7	5	1	2
L:L:?1	R:R:G82	2.41	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	282
Number of Links	295
Number of Hubs	31
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	106125
Length Of Smallest Path	3
Average Path Length	14.7202
Length of Longest Path	27
Minimum Path Strength	1.105
Average Path Strength	6.80018
Maximum Path Strength	16.92
Minimum Path Correlation	0.7
Average Path Correlation	0.915605
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	41.7567
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3661
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PUC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PUC
Name	(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
Synonyms	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Identifier
Formula	C21 H34 O4
Molecular Weight	350.492
SMILES
PubChem	5311493
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	5
Total Bonds	60
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>8XJO_nogp_Chain_R C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R P A V A S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8UO4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	4	2024-03-06	10.1038/s41586-024-07153-1
	8UO4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		4	2024-03-06	10.1038/s41586-024-07153-1
	8UO3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP; Mg		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UO0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UO0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.8	2024-03-06	10.1038/s41586-024-07153-1
	8UNY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8UNW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNU	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNU (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8UNT	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNT (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNS (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNR (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNQ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNP (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNO (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNN	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNN (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNM (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8UNL	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8UNL (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GGF	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGF (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.6	2024-03-06	10.1038/s41586-024-07153-1
	8GGE	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGE (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGC	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGC (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GGB	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGB (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GGA (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.5	2024-03-06	10.1038/s41586-024-07153-1
	8GG9	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG9 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.4	2024-03-06	10.1038/s41586-024-07153-1
	8GG8	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG8 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG7 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG6 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.3	2024-03-06	10.1038/s41586-024-07153-1
	8GG5	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG5 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG4 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.2	2024-03-06	10.1038/s41586-024-07153-1
	8GG3	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG3 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GG2	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG2 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GG1 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GG0	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GG0 (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		2.9	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFZ (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFX (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3	2024-03-06	10.1038/s41586-024-07153-1
	8GFW (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3	2024-03-06	10.1038/s41586-024-07153-1
	8GFV	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP	Gs/β1/γ2	3.1	2024-03-06	10.1038/s41586-024-07153-1
	8GFV (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	Constrained Epinephrine	GTP		3.1	2024-03-06	10.1038/s41586-024-07153-1
	8XJO	A	Lipid	Prostanoid	TP	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	To be published
	8XJO (No Gprot)	A	Lipid	Prostanoid	TP	Homo sapiens	U46619	-		3.11	2024-02-28	To be published
	8XJN	A	Lipid	Prostanoid	TP	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TP	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	7VUI	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP	chim(Gs-CtGq)/β1/γ2	3.3	2021-12-29	10.1038/s41422-021-00591-w
	7VUI (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	JNJ-63533054	GTP		3.3	2021-12-29	10.1038/s41422-021-00591-w
	6TPK	A	Peptide	Vasopressin and Oxytocin	OT	Homo sapiens	Retosiban	-	-	3.2	2020-08-05	10.1126/sciadv.abb5419
	6V9S	A	Peptide	Orexin	OX₁	Homo sapiens	GTPL11403	-	-	3.5	2020-07-15	10.1073/pnas.2002704117
	6OBA	A	Amine	Adrenergic	β₂	Homo sapiens	S-Alprenolol	GTPL11074	-	3.1	2020-03-25	10.1038/s41589-020-0549-2
	6TP6	A	Peptide	Orexin	OX₁	Homo sapiens	Filorexant	-	-	2.34	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP4	A	Peptide	Orexin	OX₁	Homo sapiens	ACT-462206	-	-	3.01	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TP3	A	Peptide	Orexin	OX₁	Homo sapiens	Nemorexant	-	-	3.04	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6IIV	A	Lipid	Prostanoid	TP	Homo sapiens	Daltroban	-	-	3	2018-12-19	10.1038/s41589-018-0170-9
	6IIU	A	Lipid	Prostanoid	TP	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	10.1038/s41589-018-0170-9
	4PY0	A	Nucleotide	P2Y	P2Y₁₂	Homo sapiens	2MeSATP	-	-	3.1	2014-04-30	10.1038/nature13288
	3UZA	A	Nucleotide	Adenosine	A_2A	Homo sapiens	GTPL9236	-	-	3.27	2012-03-21	10.1021/jm201376w

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