psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C102	R:R:C11	7.28	No	No	0	2	4
2	R:R:C105	R:R:C11	3.64	No	No	0	9	4
3	R:R:P14	R:R:R13	4.32	No	No	3	3	4
4	R:R:Q281	R:R:R13	15.19	No	No	3	4	4
5	R:R:E287	R:R:R13	5.82	No	No	0	3	4
6	R:R:P14	R:R:Q281	11.05	No	No	3	3	4
7	R:R:I17	R:R:T15	4.56	No	No	0	3	4
8	R:R:I17	R:R:Y178	9.67	No	Yes	0	3	3
9	R:R:E20	R:R:T18	5.64	No	No	0	3	8
10	R:R:R284	R:R:T18	6.47	No	No	0	1	8
11	R:R:E21	R:R:I25	9.56	No	No	4	2	3
12	R:R:E21	R:R:K288	14.85	No	No	4	2	1
13	R:R:R22	R:R:R23	10.66	No	No	0	1	1
14	R:R:F93	R:R:R22	4.28	No	No	0	3	1
15	R:R:P28	R:R:R23	11.53	No	No	0	6	1
16	R:R:I25	R:R:K288	10.18	No	No	4	3	1
17	R:R:A26	R:R:P179	3.74	No	No	0	4	8
18	R:R:F30	R:R:S27	3.96	No	No	0	5	7
19	R:R:P28	R:R:W29	5.4	No	No	0	6	3
20	R:R:H89	R:R:P28	4.58	No	No	0	7	6
21	R:R:F30	R:R:F34	4.29	No	No	0	5	8
22	R:R:F30	R:R:R295	23.52	No	No	0	5	8
23	L:L:?1	R:R:A31	6.67	Yes	No	0	0	7
24	R:R:F34	R:R:T298	5.19	No	No	0	8	8
25	R:R:F34	R:R:W299	12.03	No	No	0	8	4
26	L:L:?1	R:R:C35	5.6	Yes	No	0	0	6
27	R:R:G38	R:R:I302	7.05	No	No	0	9	9
28	R:R:F75	R:R:L39	4.87	Yes	No	0	7	6
29	R:R:S41	R:R:W306	8.65	No	No	0	9	8
30	R:R:D74	R:R:N42	6.73	Yes	No	0	9	9
31	R:R:F75	R:R:N42	3.62	Yes	No	0	7	9
32	R:R:N42	R:R:P305	11.4	No	No	0	9	9
33	R:R:F75	R:R:L43	8.53	Yes	No	0	7	5
34	R:R:A45	R:R:I309	4.87	No	No	0	9	9
35	R:R:A45	R:R:L310	4.73	No	No	0	9	8
36	R:R:L46	R:R:L49	4.15	No	Yes	0	7	8
37	R:R:L46	R:R:V71	7.45	No	No	0	7	8
38	R:R:V315	R:R:V48	4.81	No	No	0	7	8
39	R:R:L49	R:R:L67	4.15	Yes	Yes	1	8	8
40	R:R:H58	R:R:S57	6.97	No	No	0	5	5
41	R:R:F66	R:R:S62	6.61	Yes	No	0	7	6
42	R:R:E129	R:R:S62	7.19	No	No	0	9	6
43	R:R:F63	R:R:L67	6.09	No	Yes	1	8	8
44	R:R:F63	R:R:M126	4.98	No	Yes	1	8	9
45	R:R:F63	R:R:R130	10.69	No	Yes	1	8	9
46	R:R:Q146	R:R:T65	5.67	No	No	0	5	6
47	R:R:A149	R:R:T65	5.03	No	No	0	7	6
48	R:R:T65	R:R:W150	8.49	No	No	0	6	4
49	R:R:F66	R:R:M126	4.98	Yes	Yes	0	7	9
50	R:R:F66	R:R:T152	6.49	Yes	No	0	7	4
51	R:R:F66	R:R:V153	3.93	Yes	No	0	7	7
52	R:R:L67	R:R:M126	4.24	Yes	Yes	1	8	9
53	R:R:L67	R:R:Y308	3.52	Yes	Yes	1	8	9
54	R:R:I309	R:R:L67	8.56	No	Yes	0	9	8
55	R:R:D74	R:R:L70	8.14	Yes	Yes	1	9	9
56	R:R:L122	R:R:L70	4.15	No	Yes	0	7	9
57	R:R:D304	R:R:L70	8.14	Yes	Yes	1	9	9
58	R:R:L70	R:R:Y308	4.69	Yes	Yes	1	9	9
59	R:R:S118	R:R:T73	4.8	No	No	2	7	9
60	R:R:T73	R:R:W157	7.28	No	No	2	9	7
61	R:R:D74	R:R:P119	6.44	Yes	No	1	9	8
62	R:R:D74	R:R:Q301	9.14	Yes	Yes	1	9	9
63	R:R:D304	R:R:D74	6.65	Yes	Yes	1	9	9
64	R:R:F75	R:R:L76	3.65	Yes	No	0	7	6
65	R:R:F115	R:R:L76	3.65	No	No	0	7	6
66	R:R:F115	R:R:G77	7.53	No	No	0	7	8
67	R:R:L78	R:R:Q301	3.99	No	Yes	1	8	9
68	L:L:?1	R:R:L78	5.86	Yes	No	1	0	8
69	L:L:?1	R:R:T81	10.4	Yes	No	0	0	7
70	R:R:I84	R:R:M108	5.83	No	No	0	5	6
71	L:L:?1	R:R:V85	9.46	Yes	No	0	0	8
72	R:R:Q88	R:R:W95	15.33	No	Yes	0	6	6
73	R:R:H89	R:R:S181	8.37	No	No	1	7	8
74	L:L:?1	R:R:H89	9.07	Yes	No	1	0	7
75	R:R:L92	R:R:V98	17.88	No	No	0	4	5
76	R:R:E94	R:R:H96	4.92	No	No	0	4	2
77	R:R:L104	R:R:W95	10.25	No	Yes	0	6	6
78	R:R:C105	R:R:W95	3.92	No	Yes	0	9	6
79	R:R:V176	R:R:W95	3.68	No	Yes	0	4	6
80	R:R:D99	R:R:L104	6.79	Yes	No	0	5	6
81	R:R:C105	R:R:C183	7.28	No	No	0	9	9
82	R:R:L168	R:R:R106	6.07	No	No	0	5	5
83	R:R:M108	R:R:M112	5.78	No	No	0	6	8
84	R:R:G109	R:R:Y174	11.59	No	Yes	0	8	6
85	R:R:F184	R:R:M112	4.98	Yes	No	0	8	8
86	L:L:?1	R:R:M112	5.99	Yes	No	0	0	8
87	R:R:G164	R:R:I113	3.53	No	Yes	0	7	7
88	R:R:I113	R:R:Y174	4.84	Yes	Yes	0	7	6
89	R:R:F184	R:R:I113	3.77	Yes	Yes	0	8	7
90	R:R:F200	R:R:I113	6.28	No	Yes	0	8	7
91	R:R:F114	R:R:F115	10.72	Yes	No	0	7	7
92	R:R:F114	R:R:S118	7.93	Yes	No	2	7	7
93	R:R:F114	R:R:W157	8.02	Yes	No	2	7	7
94	R:R:F114	R:R:L161	7.31	Yes	No	0	7	4
95	L:L:?1	R:R:G116	6.03	Yes	No	0	0	7
96	R:R:L117	R:R:L121	4.15	No	No	0	7	6
97	R:R:L117	R:R:L203	4.15	No	No	0	7	5
98	R:R:S118	R:R:W157	4.94	No	No	2	7	7
99	R:R:P119	R:R:Q301	7.9	No	Yes	1	8	9
100	R:R:L120	R:R:W258	13.67	No	Yes	0	8	8
101	R:R:L121	R:R:V156	5.96	No	No	0	6	6
102	R:R:L121	R:R:S207	4.5	No	No	0	6	7
103	R:R:L122	R:R:V156	5.96	No	No	0	7	6
104	R:R:A124	R:R:L210	4.73	No	No	0	6	6
105	R:R:M126	R:R:Y308	10.78	Yes	Yes	1	9	9
106	R:R:E129	R:R:R140	16.28	No	Yes	0	9	8
107	R:R:M243	R:R:R130	3.72	No	Yes	1	8	9
108	R:R:Q246	R:R:R130	15.19	No	Yes	0	8	9
109	R:R:L247	R:R:R130	4.86	Yes	Yes	1	8	9
110	R:R:L132	R:R:Y131	3.52	No	Yes	0	6	7
111	R:R:T135	R:R:Y131	14.98	No	Yes	0	7	7
112	R:R:L214	R:R:Y131	3.52	Yes	Yes	0	7	7
113	R:R:V217	R:R:Y131	7.57	No	Yes	0	5	7
114	R:R:S218	R:R:Y131	3.82	No	Yes	0	9	7
115	R:R:L132	R:R:R136	6.07	No	No	0	6	5
116	R:R:L132	R:R:R140	13.36	No	Yes	0	6	8
117	R:R:I134	R:R:L222	5.71	No	No	0	8	8
118	R:R:R136	R:R:S139	5.27	No	No	0	5	4
119	R:R:R147	R:R:R148	8.53	No	No	0	5	5
120	R:R:V153	R:R:W150	4.9	No	No	0	7	4
121	R:R:F196	R:R:L163	4.87	Yes	No	0	7	6
122	R:R:F196	R:R:L166	4.87	Yes	No	0	7	8
123	R:R:P167	R:R:Y174	22.25	No	Yes	0	9	6
124	R:R:F196	R:R:P167	8.67	Yes	No	0	7	9
125	R:R:R173	R:R:T186	16.82	No	No	0	3	4
126	R:R:E190	R:R:R173	9.3	No	No	5	1	3
127	R:R:D193	R:R:R173	5.96	No	No	5	4	3
128	R:R:T175	R:R:T186	7.85	No	No	0	3	4
129	R:R:Q177	R:R:W182	9.86	No	Yes	0	7	7
130	R:R:P179	R:R:Y178	11.13	No	Yes	0	8	3
131	R:R:R284	R:R:Y178	15.43	No	Yes	0	1	3
132	R:R:E287	R:R:Y178	10.1	No	Yes	0	3	3
133	R:R:P179	R:R:S181	3.56	No	No	0	8	8
134	L:L:?1	R:R:S181	5.3	Yes	No	1	0	8
135	R:R:F184	R:R:W182	7.02	Yes	Yes	0	8	7
136	R:R:L294	R:R:W182	6.83	No	Yes	1	7	7
137	L:L:?1	R:R:W182	12.86	Yes	Yes	1	0	7
138	R:R:F184	R:R:L185	12.18	Yes	No	0	8	5
139	R:R:F196	R:R:L185	8.53	Yes	No	0	7	5
140	R:R:F200	R:R:L185	3.65	No	No	0	8	5
141	R:R:L187	R:R:T268	5.9	No	No	0	6	6
142	R:R:D193	R:R:G188	5.03	No	No	0	4	4
143	R:R:A189	R:R:P274	3.74	No	No	0	3	1
144	R:R:D193	R:R:E190	10.39	No	No	5	4	1
145	R:R:L198	R:R:L270	4.15	No	No	0	4	3
146	R:R:G204	R:R:S207	3.71	No	No	0	7	7
147	R:R:L259	R:R:V208	4.47	No	No	0	6	7
148	R:R:L210	R:R:L214	5.54	No	Yes	0	6	7
149	R:R:F212	R:R:T216	3.89	No	No	0	5	5
150	R:R:F212	R:R:M251	7.46	No	No	0	5	8
151	R:R:F212	R:R:S255	3.96	No	No	0	5	5
152	R:R:L247	R:R:N215	5.49	Yes	No	0	8	9
153	R:R:I250	R:R:N215	4.25	No	No	0	8	9
154	R:R:L247	R:R:V219	4.47	Yes	No	0	8	7
155	R:R:L222	R:R:M244	4.24	No	No	0	8	6
156	R:R:C223	R:R:M244	4.86	No	No	0	4	6
157	R:R:E240	R:R:V225	8.56	No	No	0	8	7
158	R:R:R237	R:R:Y226	17.49	No	Yes	0	5	6
159	R:R:V241	R:R:Y226	5.05	No	Yes	0	4	6
160	R:R:M244	R:R:Y226	3.59	No	Yes	0	6	6
161	R:R:E230	R:R:Q229	3.82	No	No	0	3	4
162	R:R:E240	R:R:R235	6.98	No	No	0	8	7
163	R:R:E242	R:R:R312	6.98	No	No	0	8	9
164	R:R:E242	R:R:R313	6.98	No	No	0	8	6
165	R:R:L247	R:R:M243	4.24	Yes	No	1	8	8
166	R:R:Q246	R:R:R312	26.87	No	No	0	8	9
167	R:R:I250	R:R:V307	4.61	No	Yes	0	8	8
168	R:R:I250	R:R:Y308	14.51	No	Yes	0	8	9
169	R:R:L303	R:R:V253	8.94	No	No	0	7	7
170	R:R:C257	R:R:N300	6.3	No	Yes	0	9	9
171	R:R:A297	R:R:W258	7.78	No	Yes	0	8	8
172	R:R:N300	R:R:W258	12.43	Yes	Yes	1	9	8
173	R:R:Q301	R:R:W258	6.57	Yes	Yes	1	9	8
174	L:L:?1	R:R:W258	4.82	Yes	Yes	1	0	8
175	R:R:Q267	R:R:V263	4.3	No	No	0	4	6
176	R:R:F264	R:R:T268	7.78	Yes	No	0	4	6
177	R:R:E289	R:R:F264	8.16	No	Yes	0	1	4
178	R:R:F264	R:R:L290	7.31	Yes	No	0	4	6
179	R:R:F264	R:R:Y293	9.28	Yes	No	0	4	7
180	R:R:A275	R:R:R271	5.53	No	No	0	1	3
181	R:R:L282	R:R:M276	7.07	No	No	0	4	1
182	R:R:E287	R:R:L282	5.3	No	No	0	3	4
183	R:R:S283	R:R:T286	4.8	No	No	0	1	2
184	R:R:L291	R:R:R295	12.15	No	No	0	7	8
185	L:L:?1	R:R:L294	7.81	Yes	No	1	0	7
186	L:L:?1	R:R:R295	4.29	Yes	No	0	0	8
187	L:L:?1	R:R:T298	10.4	Yes	No	0	0	8
188	R:R:I302	R:R:W299	12.92	No	No	0	9	4
189	R:R:N300	R:R:Q301	6.6	Yes	Yes	1	9	9
190	R:R:D304	R:R:N300	9.42	Yes	Yes	1	9	9
191	L:L:?1	R:R:Q301	4.7	Yes	Yes	1	0	9
192	R:R:D304	R:R:Y308	6.9	Yes	Yes	1	9	9
193	R:R:L310	R:R:W306	14.81	No	No	0	8	8
194	R:R:F311	R:R:W306	7.02	No	No	0	7	8
195	R:R:F311	R:R:V307	3.93	No	Yes	0	7	8
196	R:R:L316	R:R:R313	7.29	No	No	0	7	6
197	R:R:Q146	R:R:R53	3.5	No	No	0	5	6
198	R:R:G280	R:R:M276	3.49	No	No	0	5	1
199	R:R:A266	R:R:S201	3.42	No	No	0	5	7
200	R:R:G204	R:R:L262	3.42	No	No	0	7	8
201	R:R:C183	R:R:M108	3.24	No	No	0	9	6
202	R:R:S255	R:R:V208	3.23	No	No	0	5	7
203	R:R:D99	R:R:P100	3.22	Yes	No	0	5	4
204	R:R:V111	R:R:V80	3.21	No	No	0	5	6
205	R:R:V194	R:R:V269	3.21	No	No	0	3	5
206	R:R:V253	R:R:V307	3.21	No	Yes	0	7	8
207	R:R:S283	R:R:T285	3.2	No	No	0	1	1
208	R:R:C68	R:R:L72	3.17	No	No	0	5	5
209	R:R:T81	R:R:V111	3.17	No	No	0	7	5
210	R:R:A160	R:R:L117	3.15	No	No	0	7	7
211	R:R:A127	R:R:L214	3.15	No	Yes	0	9	7
212	R:R:I134	R:R:T221	3.04	No	No	0	8	7
213	R:R:M276	R:R:T186	3.01	No	No	0	1	4
214	R:R:L214	R:R:S128	3	Yes	No	0	7	6
215	R:R:L165	R:R:V110	2.98	No	No	0	5	6
216	R:R:L168	R:R:V110	2.98	No	No	0	5	6
217	R:R:L120	R:R:V208	2.98	No	No	0	8	7
218	R:R:Q281	R:R:S277	2.89	No	No	0	4	2
219	R:R:P141	R:R:R140	2.88	No	Yes	0	5	8
220	R:R:I265	R:R:L187	2.85	Yes	No	0	7	6
221	R:R:I265	R:R:L261	2.85	Yes	No	0	7	7
222	R:R:L222	R:R:M243	2.83	No	No	0	8	8
223	R:R:L248	R:R:M251	2.83	No	No	0	6	8
224	R:R:E21	R:R:T18	2.82	No	No	0	2	8
225	R:R:P260	R:R:Y293	2.78	No	No	0	9	7
226	R:R:L39	R:R:L79	2.77	No	No	0	6	6
227	R:R:L310	R:R:L44	2.77	No	No	0	8	5
228	R:R:A142	R:R:R60	2.77	No	No	0	5	6
229	R:R:A125	R:R:F66	2.77	No	Yes	0	6	7
230	R:R:L163	R:R:L199	2.77	No	No	0	6	4
231	R:R:L199	R:R:L203	2.77	No	No	0	4	5
232	R:R:A232	R:R:R237	2.77	No	No	0	4	5
233	R:R:L290	R:R:Q177	2.66	No	No	0	6	7
234	R:R:F107	R:R:V80	2.62	No	No	0	6	6
235	R:R:R312	R:R:V315	2.62	No	No	0	9	7
236	R:R:F264	R:R:T286	2.59	Yes	No	0	4	2
237	R:R:H58	R:R:L64	2.57	No	No	0	5	7
238	R:R:V37	R:R:W299	2.45	No	No	0	6	4
239	L:L:?1	R:R:G82	2.41	Yes	No	0	0	8
240	R:R:L168	R:R:Y174	2.34	No	Yes	0	5	6
241	R:R:Q234	R:R:R235	2.34	No	No	0	4	7
242	R:R:E94	R:R:F93	2.33	No	No	0	4	3
243	R:R:G55	R:R:G56	2.11	No	No	0	3	5
244	R:R:G204	R:R:G205	2.11	No	No	0	7	5
245	R:R:G172	R:R:P167	2.03	No	No	0	8	9
246	R:R:C68	R:R:G69	1.96	No	No	0	5	7
247	R:R:A50	R:R:G51	1.95	No	No	0	3	7
248	R:R:A195	R:R:G192	1.95	No	No	0	5	1
249	R:R:P273	R:R:P274	1.95	No	No	0	1	1
250	R:R:G123	R:R:S211	1.86	No	No	0	8	8
251	R:R:G192	R:R:S191	1.86	No	No	0	1	2
252	R:R:G180	R:R:V176	1.84	No	No	0	5	4
253	R:R:G249	R:R:V307	1.84	No	Yes	0	5	8
254	R:R:P278	R:R:S277	1.78	No	No	0	7	2
255	R:R:G197	R:R:I265	1.76	No	Yes	0	6	7
256	R:R:A144	R:R:S62	1.71	No	No	0	5	6
257	R:R:A124	R:R:S211	1.71	No	No	0	6	8
258	R:R:A127	R:R:S211	1.71	No	No	0	9	8
259	R:R:A279	R:R:S277	1.71	No	No	0	1	2
260	R:R:A32	R:R:V86	1.7	No	No	0	5	7
261	R:R:A195	R:R:V171	1.7	No	No	0	5	4
262	R:R:A231	R:R:V225	1.7	No	No	0	3	7
263	R:R:D99	R:R:G101	1.68	Yes	No	0	5	3
264	R:R:A275	R:R:T268	1.68	No	No	0	1	6
265	R:R:D238	R:R:P236	1.61	No	No	0	5	3
266	R:R:V252	R:R:V256	1.6	No	No	0	5	6
267	R:R:C68	R:R:L49	1.59	No	Yes	0	5	8
268	R:R:A266	R:R:L198	1.58	No	No	0	5	4
269	R:R:A254	R:R:N300	1.56	No	Yes	0	8	9
270	R:R:I265	R:R:V269	1.54	Yes	No	0	7	5
271	R:R:A50	R:R:Q54	1.52	No	No	0	3	5
272	R:R:I84	R:R:T83	1.52	No	No	0	5	8
273	R:R:A97	R:R:E94	1.51	No	No	0	4	4
274	R:R:G133	R:R:R140	1.5	No	Yes	0	8	8
275	R:R:L262	R:R:S201	1.5	No	No	0	8	7
276	R:R:L166	R:R:V171	1.49	No	No	0	8	4
277	R:R:L213	R:R:T216	1.47	No	No	0	4	5
278	R:R:D238	R:R:S239	1.47	No	No	0	5	6
279	R:R:E129	R:R:S61	1.44	No	No	0	9	7
280	R:R:P137	R:R:R136	1.44	No	No	0	8	5
281	R:R:P236	R:R:R235	1.44	No	No	0	3	7
282	R:R:I25	R:R:L24	1.43	No	No	0	3	1
283	R:R:Q146	R:R:T59	1.42	No	No	0	5	7
284	R:R:L49	R:R:L64	1.38	Yes	No	1	8	7
285	R:R:A52	R:R:R318	1.38	No	No	0	6	6
286	R:R:L64	R:R:L67	1.38	No	Yes	1	7	8
287	R:R:E20	R:R:L19	1.33	No	No	0	3	3
288	R:R:R148	R:R:S145	1.32	No	No	0	5	7
289	R:R:Q229	R:R:Q233	1.28	No	No	0	4	4
290	R:R:I292	R:R:Y293	1.21	No	No	0	4	7
291	R:R:D99	R:R:R103	1.19	Yes	No	0	5	2
292	R:R:Q320	R:R:R317	1.17	No	No	0	3	5
293	R:R:F12	R:R:H96	1.13	No	No	0	3	2
294	R:R:E240	R:R:Y226	1.12	No	Yes	0	8	6
295	R:R:H227	R:R:Y226	1.09	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L49	2.8175	4	1	8
2	R:R:F66	4.956	5	0	7
3	R:R:L67	4.65667	6	1	8
4	R:R:L70	6.28	4	1	9
5	R:R:D74	7.42	5	1	9
6	R:R:F75	5.1675	4	0	7
7	R:R:W95	8.295	4	0	6
8	R:R:D99	3.22	4	0	5
9	R:R:I113	4.605	4	0	7
10	R:R:F114	8.495	4	2	7
11	R:R:M126	6.245	4	1	9
12	R:R:R130	8.615	4	1	9
13	R:R:Y131	6.682	5	0	7
14	R:R:R140	8.505	4	0	8
15	R:R:Y174	10.255	4	0	6
16	R:R:Y178	11.5825	4	0	3
17	R:R:W182	9.1425	4	1	7
18	R:R:F184	6.9875	4	0	8
19	R:R:F196	6.735	4	0	7
20	R:R:L214	3.8025	4	0	7
21	R:R:Y226	5.668	5	0	6
22	R:R:L247	4.765	4	1	8
23	R:R:W258	9.054	5	1	8
24	R:R:F264	7.024	5	0	4
25	R:R:I265	2.25	4	0	7
26	R:R:N300	7.262	5	1	9
27	R:R:Q301	6.48333	6	1	9
28	R:R:D304	7.7775	4	1	9
29	R:R:V307	3.3975	4	0	8
30	R:R:Y308	8.08	5	1	9
31	L:L:?1	6.97938	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C105	R:R:C183	14.169	7.28	No	No	0	9	9
2	R:R:C183	R:R:M108	15.3286	3.24	No	No	0	9	6
3	R:R:M108	R:R:M112	18.4186	5.78	No	No	0	6	8
4	L:L:?1	R:R:M112	41.4328	5.99	Yes	No	0	0	8
5	L:L:?1	R:R:S181	33.9276	5.3	Yes	No	1	0	8
6	R:R:P179	R:R:S181	33.4799	3.56	No	No	0	8	8
7	R:R:P179	R:R:Y178	31.246	11.13	No	Yes	0	8	3
8	R:R:E287	R:R:Y178	18.8942	10.1	No	Yes	0	3	3
9	L:L:?1	R:R:H89	11.2578	9.07	Yes	No	1	0	7
10	R:R:H89	R:R:P28	10.7445	4.58	No	No	0	7	6
11	L:L:?1	R:R:Q301	99.8261	4.7	Yes	Yes	1	0	9
12	R:R:D74	R:R:Q301	69.3576	9.14	Yes	Yes	1	9	9
13	R:R:D74	R:R:N42	11.0692	6.73	Yes	No	0	9	9
14	L:L:?1	R:R:W258	34.3098	4.82	Yes	Yes	1	0	8
15	R:R:N300	R:R:W258	34.4098	12.43	Yes	Yes	1	9	8
16	R:R:D304	R:R:N300	65.7952	9.42	Yes	Yes	1	9	9
17	R:R:D304	R:R:Y308	100	6.9	Yes	Yes	1	9	9
18	R:R:I250	R:R:Y308	31.7544	14.51	No	Yes	0	8	9
19	R:R:N300	R:R:Q301	32.1464	6.6	Yes	Yes	1	9	9
20	R:R:D304	R:R:D74	35.2561	6.65	Yes	Yes	1	9	9
21	R:R:D74	R:R:L70	37.9262	8.14	Yes	Yes	1	9	9
22	R:R:L70	R:R:Y308	38.6462	4.69	Yes	Yes	1	9	9
23	R:R:L67	R:R:Y308	43.6224	3.52	Yes	Yes	1	8	9
24	R:R:F63	R:R:L67	29.4944	6.09	No	Yes	1	8	8
25	R:R:F63	R:R:R130	57.711	10.69	No	Yes	1	8	9
26	R:R:Q246	R:R:R130	15.1154	15.19	No	Yes	0	8	9
27	R:R:Q246	R:R:R312	13.0603	26.87	No	No	0	8	9
28	R:R:M126	R:R:Y308	63.7057	10.78	Yes	Yes	1	9	9
29	R:R:F63	R:R:M126	30.2997	4.98	No	Yes	1	8	9
30	R:R:F66	R:R:M126	36.3976	4.98	Yes	Yes	0	7	9
31	R:R:F66	R:R:S62	25.5072	6.61	Yes	No	0	7	6
32	R:R:E129	R:R:S62	23.252	7.19	No	No	0	9	6
33	R:R:C105	R:R:W95	10.6706	3.92	No	Yes	0	9	6
34	R:R:F184	R:R:M112	24.4378	4.98	Yes	No	0	8	8
35	R:R:F184	R:R:I113	23.7506	3.77	Yes	Yes	0	8	7
36	R:R:I113	R:R:Y174	17.3394	4.84	Yes	Yes	0	7	6
37	R:R:F184	R:R:L185	22.6173	12.18	Yes	No	0	8	5
38	R:R:F196	R:R:L185	18.5498	8.53	Yes	No	0	7	5
39	R:R:L132	R:R:Y131	12.9521	3.52	No	Yes	0	6	7
40	R:R:L132	R:R:R140	17.5641	13.36	No	Yes	0	6	8
41	R:R:E129	R:R:R140	20.9887	16.28	No	Yes	0	9	8
42	R:R:M243	R:R:R130	40.9014	3.72	No	Yes	1	8	9
43	R:R:I250	R:R:N215	23.1864	4.25	No	No	0	8	9
44	R:R:L247	R:R:N215	22.0941	5.49	Yes	No	0	8	9
45	R:R:L247	R:R:M243	19.898	4.24	Yes	No	1	8	8
46	R:R:L222	R:R:M243	57.7356	2.83	No	No	0	8	8
47	R:R:F196	R:R:L166	11.02	4.87	Yes	No	0	7	8
48	R:R:E287	R:R:L282	10.7297	5.3	No	No	0	3	4
49	R:R:F184	R:R:W182	24.6133	7.02	Yes	Yes	0	8	7
50	R:R:Q177	R:R:W182	21.7612	9.86	No	Yes	0	7	7
51	L:L:?1	R:R:W182	44.4392	12.86	Yes	Yes	1	0	7
52	R:R:L290	R:R:Q177	20.6426	2.66	No	No	0	6	7
53	R:R:F264	R:R:L290	19.6733	7.31	Yes	No	0	4	6
54	R:R:F264	R:R:T268	10.6264	7.78	Yes	No	0	4	6
55	R:R:L222	R:R:M244	48.3459	4.24	No	No	0	8	6
56	R:R:M244	R:R:Y226	41.8445	3.59	No	Yes	0	6	6
57	R:R:E240	R:R:Y226	25.9812	1.12	No	Yes	0	8	6
58	R:R:E240	R:R:R235	16.1667	6.98	No	No	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H89	R:R:P28	4.58	1	No	No	7	6	1	2
R:R:F30	R:R:F34	4.29	0	No	No	5	8	2	2
R:R:F30	R:R:R295	23.52	0	No	No	5	8	2	1
L:L:?1	R:R:A31	6.67	1	Yes	No	0	7	0	1
R:R:F34	R:R:T298	5.19	0	No	No	8	8	2	1
L:L:?1	R:R:C35	5.6	1	Yes	No	0	6	0	1
R:R:D74	R:R:P119	6.44	1	Yes	No	9	8	2	2
R:R:D74	R:R:Q301	9.14	1	Yes	Yes	9	9	2	1
R:R:L78	R:R:Q301	3.99	1	No	Yes	8	9	1	1
L:L:?1	R:R:L78	5.86	1	Yes	No	0	8	0	1
L:L:?1	R:R:T81	10.4	1	Yes	No	0	7	0	1
L:L:?1	R:R:V85	9.46	1	Yes	No	0	8	0	1
R:R:H89	R:R:S181	8.37	1	No	No	7	8	1	1
L:L:?1	R:R:H89	9.07	1	Yes	No	0	7	0	1
R:R:M108	R:R:M112	5.78	0	No	No	6	8	2	1
R:R:F184	R:R:M112	4.98	0	Yes	No	8	8	2	1
L:L:?1	R:R:M112	5.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:G116	6.03	1	Yes	No	0	7	0	1
R:R:P119	R:R:Q301	7.9	1	No	Yes	8	9	2	1
R:R:L120	R:R:W258	13.67	0	No	Yes	8	8	2	1
R:R:Q177	R:R:W182	9.86	0	No	Yes	7	7	2	1
R:R:P179	R:R:S181	3.56	0	No	No	8	8	2	1
L:L:?1	R:R:S181	5.3	1	Yes	No	0	8	0	1
R:R:F184	R:R:W182	7.02	0	Yes	Yes	8	7	2	1
R:R:L294	R:R:W182	6.83	1	No	Yes	7	7	1	1
L:L:?1	R:R:W182	12.86	1	Yes	Yes	0	7	0	1
R:R:A297	R:R:W258	7.78	0	No	Yes	8	8	2	1
R:R:N300	R:R:W258	12.43	1	Yes	Yes	9	8	2	1
R:R:Q301	R:R:W258	6.57	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:W258	4.82	1	Yes	Yes	0	8	0	1
R:R:L291	R:R:R295	12.15	0	No	No	7	8	2	1
L:L:?1	R:R:L294	7.81	1	Yes	No	0	7	0	1
L:L:?1	R:R:R295	4.29	1	Yes	No	0	8	0	1
L:L:?1	R:R:T298	10.4	1	Yes	No	0	8	0	1
R:R:N300	R:R:Q301	6.6	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:Q301	4.7	1	Yes	Yes	0	9	0	1
R:R:T81	R:R:V111	3.17	0	No	No	7	5	1	2
L:L:?1	R:R:G82	2.41	1	Yes	No	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	282
Number of Links	295
Number of Hubs	31
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	35
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	106125
Length Of Smallest Path	3
Average Path Length	14.7202
Length of Longest Path	27
Minimum Path Strength	1.105
Average Path Strength	6.80018
Maximum Path Strength	16.92
Minimum Path Correlation	0.7
Average Path Correlation	0.915622
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	41.7567
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3661
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • response to ketone • response to lipid • response to oxygen-containing compound • response to testosterone • regulation of blood pressure • positive regulation of blood pressure • smooth muscle contraction • muscle contraction • muscle system process • cellular response to stimulus • biological process involved in interspecies interaction between organisms • response to other organism • cellular response to lipopolysaccharide • response to external stimulus • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • response to biotic stimulus • cellular response to biotic stimulus • cellular response to chemical stimulus • response to bacterium • cellular response to lipid • cellular process • response to external biotic stimulus • response to molecule of bacterial origin • response to alcohol • response to ethanol • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • negative regulation of locomotion • regulation of cell motility • cell migration involved in sprouting angiogenesis • regulation of blood vessel endothelial cell migration • endothelial cell migration • negative regulation of biological process • negative regulation of endothelial cell migration • negative regulation of blood vessel endothelial cell migration • regulation of cell migration • negative regulation of cellular process • regulation of endothelial cell migration • blood vessel endothelial cell migration • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of cell migration involved in sprouting angiogenesis • sprouting angiogenesis • regulation of locomotion • negative regulation of cell motility • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of smooth muscle contraction • regulation of muscle system process • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of body fluid levels • positive regulation of coagulation • regulation of response to external stimulus • positive regulation of blood coagulation • regulation of response to wounding • regulation of coagulation • positive regulation of response to stimulus • response to stress • regulation of response to stress • coagulation • positive regulation of hemostasis • response to wounding • regulation of hemostasis • positive regulation of response to wounding • wound healing • regulation of blood coagulation • hemostasis • blood coagulation • positive regulation of wound healing • regulation of response to stimulus • regulation of wound healing • defense response • inflammatory response • response to nutrient levels • response to nutrient • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • intracellular organelle lumen • nuclear speck • ribonucleoprotein granule • intracellular organelle • nuclear body • cellular anatomical structure • nucleoplasm • organelle lumen • organelle • membraneless organelle • supramolecular complex • nuclear ribonucleoprotein granule • nuclear lumen • cell periphery • plasma membrane • membrane • acrosomal vesicle • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • vesicle • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PUC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PUC
Name	(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
Synonyms	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Identifier
Formula	C21 H34 O4
Molecular Weight	350.492
SMILES
PubChem	5311493
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	5
Total Bonds	60
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21731
Sequence	>8XJO_nogp_Chain_R C F R P T N I T L E E R R L I A S P W F A A S F C V V G L A S N L L A L S V L A G A R Q G G S H T R S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A L F E W H A V D P G C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R P F S R P A V A S Q R R A W A T V G L V W A A A L A L G L L P L L G V G R Y T V Q Y P G S W C F L T L G A E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q E A A Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R N P P A M S P A G Q L S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A V L R R L Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IIU	A	Lipid	Prostanoid	TXA2	Homo sapiens	Ramatroban	-	-	2.5	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	6IIV	A	Lipid	Prostanoid	TXA2	Homo sapiens	Daltroban	-	-	3	2018-12-19	doi.org/10.1038/s41589-018-0170-9
	8XJN	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJN (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	Cloprosetnol	-		3.06	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJO (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.11	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	9GG5	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2025-08-27	To be published
	9GG5 (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	U46619	-		3.26	2025-08-27	To be published
	9GGG	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.25	2025-08-27	To be published
	9GGG (No Gprot)	A	Lipid	Prostanoid	TXA2	Homo sapiens	I-BOP	-		3.25	2025-08-27	To be published

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