psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:L2	5.02	Yes	No	1	0	0
2	L:L:?1	R:R:D106	14.77	Yes	Yes	1	0	5
3	L:L:?1	R:R:F110	20.98	Yes	Yes	1	0	7
4	L:L:?1	R:R:V113	4.05	Yes	No	1	0	8
5	L:L:?1	R:R:R201	12.12	Yes	Yes	1	0	5
6	L:L:?1	R:R:R205	5.51	Yes	Yes	0	0	6
7	L:L:?1	R:R:W254	3.1	Yes	Yes	1	0	9
8	L:L:?1	R:R:Y257	4.25	Yes	Yes	0	0	7
9	L:L:?1	R:R:Q258	6.03	Yes	No	1	0	8
10	L:L:L2	R:R:F81	3.65	No	No	1	0	6
11	L:L:L2	R:R:F102	3.65	No	Yes	1	0	6
12	L:L:F3	R:R:R205	7.48	No	Yes	0	0	6
13	L:L:F3	R:R:A264	4.16	No	No	0	0	4
14	R:R:A20	R:R:Y22	5.34	No	No	0	1	2
15	R:R:E278	R:R:Y22	7.86	No	No	0	3	2
16	R:R:F24	R:R:L23	3.65	No	No	0	2	4
17	R:R:L25	R:R:V285	4.47	No	No	0	2	6
18	R:R:D26	R:R:Y30	12.64	No	No	3	3	5
19	R:R:D26	R:R:K85	9.68	No	Yes	3	3	5
20	R:R:F33	R:R:T29	3.89	Yes	No	0	7	5
21	R:R:T29	R:R:V285	3.17	No	No	0	5	6
22	R:R:K85	R:R:Y30	13.14	Yes	No	3	5	5
23	R:R:A288	R:R:V32	3.39	No	No	0	5	5
24	R:R:F33	R:R:L78	7.31	Yes	No	0	7	8
25	R:R:A288	R:R:F33	4.16	No	Yes	0	5	7
26	R:R:F291	R:R:F33	5.36	Yes	Yes	0	7	7
27	R:R:F292	R:R:T36	3.89	Yes	No	0	5	7
28	R:R:F37	R:R:V41	5.24	Yes	No	0	7	6
29	R:R:F37	R:R:L78	3.65	Yes	No	0	7	8
30	R:R:F37	R:R:P79	7.22	Yes	No	0	7	9
31	R:R:C295	R:R:L39	4.76	No	No	0	8	6
32	R:R:G40	R:R:T75	5.46	No	No	0	8	6
33	R:R:T75	R:R:V41	3.17	No	No	0	6	6
34	R:R:G43	R:R:L46	5.13	No	No	0	8	7
35	R:R:D71	R:R:N44	5.39	Yes	No	0	9	9
36	R:R:F72	R:R:N44	6.04	No	No	0	7	9
37	R:R:N44	R:R:P298	8.15	No	No	0	9	9
38	R:R:F303	R:R:L46	3.65	Yes	No	0	7	7
39	R:R:A68	R:R:V47	3.39	No	Yes	0	8	9
40	R:R:P298	R:R:V47	3.53	No	Yes	0	9	9
41	R:R:V302	R:R:V47	9.62	Yes	Yes	2	7	9
42	R:R:F303	R:R:V47	5.24	Yes	Yes	2	7	9
43	R:R:I48	R:R:V69	3.07	No	No	0	7	5
44	R:R:F72	R:R:I48	5.02	No	No	0	7	7
45	R:R:R54	R:R:W49	22.99	No	No	0	5	4
46	R:R:A315	R:R:W49	3.89	No	No	0	5	4
47	R:R:M55	R:R:V50	4.56	No	No	0	5	7
48	R:R:A51	R:R:L65	3.15	No	No	0	7	6
49	R:R:G52	R:R:L65	3.42	No	No	0	4	6
50	R:R:F308	R:R:M55	4.98	Yes	No	0	9	5
51	R:R:M55	R:R:R311	9.93	No	No	0	5	5
52	R:R:H57	R:R:I62	6.63	No	No	0	6	6
53	R:R:T58	R:R:T60	3.14	No	No	0	8	7
54	R:R:T58	R:R:T61	7.85	No	No	0	8	7
55	R:R:R137	R:R:V59	9.15	Yes	No	0	6	7
56	R:R:V139	R:R:V59	3.21	No	No	0	3	7
57	R:R:A142	R:R:V59	5.09	No	No	0	7	7
58	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
59	R:R:R137	R:R:T60	3.88	Yes	No	0	6	7
60	R:R:A142	R:R:I62	3.25	No	No	0	7	6
61	R:R:I119	R:R:S63	6.19	Yes	No	0	9	7
62	R:R:I119	R:R:Y64	4.84	Yes	Yes	2	9	8
63	R:R:R123	R:R:Y64	5.14	Yes	Yes	2	9	8
64	R:R:Y301	R:R:Y64	4.96	Yes	Yes	2	9	8
65	R:R:V302	R:R:Y64	5.05	Yes	Yes	2	7	8
66	R:R:F308	R:R:Y64	4.13	Yes	Yes	2	9	8
67	R:R:L115	R:R:N66	4.12	No	No	6	8	9
68	R:R:I146	R:R:N66	12.74	No	No	0	7	9
69	R:R:N66	R:R:W150	6.78	No	Yes	6	9	9
70	R:R:D71	R:R:L67	4.07	Yes	No	2	9	9
71	R:R:L67	R:R:N297	4.12	No	Yes	2	9	9
72	R:R:L67	R:R:Y301	3.52	No	Yes	2	9	9
73	R:R:A70	R:R:W150	3.89	No	Yes	0	8	9
74	R:R:D71	R:R:S112	7.36	Yes	No	0	9	9
75	R:R:D71	R:R:S294	11.78	Yes	No	0	9	8
76	R:R:D71	R:R:N297	6.73	Yes	Yes	2	9	9
77	R:R:C73	R:R:N108	4.72	No	No	0	7	8
78	R:R:F74	R:R:V105	5.24	Yes	No	0	7	6
79	R:R:F74	R:R:L109	18.27	Yes	No	1	7	8
80	R:R:F291	R:R:F74	18.22	Yes	Yes	1	7	7
81	R:R:F74	R:R:S294	5.28	Yes	No	0	7	8
82	R:R:S76	R:R:T77	3.2	No	No	0	5	7
83	R:R:I104	R:R:T77	4.56	No	No	0	5	7
84	R:R:T77	R:R:V105	3.17	No	No	0	7	6
85	R:R:F80	R:R:W91	5.01	No	Yes	1	6	9
86	R:R:F80	R:R:F93	6.43	No	Yes	1	6	7
87	R:R:F80	R:R:V101	7.87	No	No	1	6	5
88	R:R:F102	R:R:F81	4.29	Yes	No	1	6	6
89	R:R:F81	R:R:V105	7.87	No	No	0	6	6
90	R:R:R84	R:R:W91	6	No	Yes	0	5	9
91	R:R:D284	R:R:K85	6.91	No	Yes	0	5	5
92	R:R:M87	R:R:P92	6.71	No	Yes	0	4	2
93	R:R:H90	R:R:P92	7.63	Yes	Yes	0	4	2
94	R:R:H90	R:R:T173	6.85	Yes	No	0	4	3
95	R:R:H90	R:R:V174	5.54	Yes	No	0	4	5
96	R:R:P92	R:R:W91	5.4	Yes	Yes	1	2	9
97	R:R:F93	R:R:W91	16.04	Yes	Yes	1	7	9
98	R:R:L97	R:R:W91	3.42	No	Yes	1	6	9
99	R:R:C98	R:R:W91	6.53	No	Yes	1	9	9
100	R:R:V101	R:R:W91	4.9	No	Yes	1	5	9
101	R:R:C176	R:R:W91	10.45	No	Yes	1	9	9
102	R:R:F93	R:R:P92	7.22	Yes	Yes	1	7	2
103	R:R:F93	R:R:L97	6.09	Yes	No	1	7	6
104	R:R:T165	R:R:W95	7.28	No	No	0	4	3
105	R:R:F100	R:R:F96	6.43	No	No	0	5	1
106	R:R:C98	R:R:T166	3.38	No	No	0	9	5
107	R:R:C176	R:R:C98	7.28	No	No	1	9	9
108	R:R:K99	R:R:V164	6.07	No	No	0	7	5
109	R:R:F102	R:R:V164	5.24	Yes	No	0	6	5
110	R:R:I161	R:R:T103	9.12	No	No	0	5	6
111	R:R:D106	R:R:F110	3.58	Yes	Yes	1	5	7
112	R:R:D106	R:R:T157	11.56	Yes	Yes	1	5	7
113	R:R:D106	R:R:V160	5.84	Yes	No	1	5	4
114	R:R:D106	R:R:R201	5.96	Yes	Yes	1	5	5
115	R:R:I107	R:R:N108	5.66	No	No	0	5	8
116	R:R:I107	R:R:T157	4.56	No	Yes	0	5	7
117	R:R:N108	R:R:W150	3.39	No	Yes	0	8	9
118	R:R:L109	R:R:W254	4.56	No	Yes	1	8	9
119	R:R:F291	R:R:L109	4.87	Yes	No	1	7	8
120	R:R:F110	R:R:F114	7.5	Yes	No	0	7	6
121	R:R:F110	R:R:L156	8.53	Yes	Yes	0	7	5
122	R:R:F114	R:R:G111	4.52	No	No	0	6	7
123	R:R:P213	R:R:V113	5.3	Yes	No	0	9	8
124	R:R:V113	R:R:W254	4.9	No	Yes	1	8	9
125	R:R:F114	R:R:M152	6.22	No	No	0	6	4
126	R:R:L115	R:R:P149	6.57	No	No	0	8	7
127	R:R:L115	R:R:W150	3.42	No	Yes	6	8	9
128	R:R:F250	R:R:I116	11.3	No	No	0	9	8
129	R:R:I116	R:R:N297	5.66	No	Yes	2	8	9
130	R:R:I116	R:R:Y301	9.67	No	Yes	2	8	9
131	R:R:A117	R:R:P213	3.74	No	Yes	0	7	9
132	R:R:A117	R:R:I216	3.25	No	No	0	7	6
133	R:R:I119	R:R:R123	3.76	Yes	Yes	2	9	9
134	R:R:I119	R:R:Y301	6.04	Yes	Yes	2	9	9
135	R:R:A120	R:R:V217	3.39	No	No	0	9	8
136	R:R:A120	R:R:Y221	6.67	No	Yes	0	9	8
137	R:R:C126	R:R:D122	4.67	No	No	5	8	8
138	R:R:D122	R:R:R137	11.91	No	Yes	5	8	6
139	R:R:R123	R:R:Y221	10.29	Yes	Yes	0	9	8
140	R:R:R123	R:R:Y301	6.17	Yes	Yes	2	9	9
141	R:R:C124	R:R:L128	3.17	Yes	No	7	8	8
142	R:R:C124	R:R:S220	5.16	Yes	No	0	8	8
143	R:R:C124	R:R:L223	3.17	Yes	Yes	7	8	4
144	R:R:C124	R:R:I224	3.27	Yes	No	0	8	8
145	R:R:C126	R:R:R137	6.96	No	Yes	5	8	6
146	R:R:K227	R:R:V127	4.55	No	No	0	5	8
147	R:R:L128	R:R:L223	5.54	No	Yes	7	8	4
148	R:R:K227	R:R:L128	4.23	No	No	0	5	8
149	R:R:T133	R:R:W132	3.64	No	Yes	0	5	4
150	R:R:H136	R:R:W132	15.87	No	Yes	0	4	4
151	R:R:R137	R:R:T133	3.88	Yes	No	0	6	5
152	R:R:H136	R:R:N135	6.38	No	No	0	4	4
153	R:R:G148	R:R:P149	4.06	No	No	0	2	7
154	R:R:T157	R:R:V160	4.76	Yes	No	1	7	4
155	R:R:R201	R:R:V160	3.92	Yes	No	1	5	4
156	R:R:I162	R:R:R163	7.52	No	No	0	4	5
157	R:R:F180	R:R:R163	5.34	Yes	No	0	5	5
158	R:R:N179	R:R:T165	5.85	No	No	0	4	4
159	R:R:T166	R:R:V174	3.17	No	No	0	5	5
160	R:R:T177	R:R:V167	4.76	No	No	0	4	1
161	R:R:F178	R:R:F180	18.22	No	Yes	0	4	5
162	R:R:F178	R:R:R201	7.48	No	Yes	0	4	5
163	R:R:N179	R:R:P182	3.26	No	No	0	4	4
164	R:R:N179	R:R:R190	6.03	No	No	0	4	3
165	R:R:F180	R:R:M197	18.66	Yes	No	0	5	2
166	R:R:F180	R:R:L198	4.87	Yes	No	0	5	4
167	R:R:S181	R:R:W183	12.36	No	No	0	5	1
168	R:R:R190	R:R:S181	3.95	No	No	0	3	5
169	R:R:S181	R:R:V193	3.23	No	No	0	5	4
170	R:R:P182	R:R:W183	8.11	No	No	0	4	1
171	R:R:E189	R:R:N185	13.15	No	No	0	4	2
172	R:R:D186	R:R:P187	6.44	No	No	0	1	4
173	R:R:D186	R:R:K188	9.68	No	No	0	1	4
174	R:R:D186	R:R:E189	9.09	No	No	0	1	4
175	R:R:N192	R:R:R269	3.62	No	Yes	0	3	1
176	R:R:I268	R:R:V195	3.07	Yes	Yes	0	3	4
177	R:R:R269	R:R:V195	11.77	Yes	Yes	0	1	4
178	R:R:I268	R:R:L198	4.28	Yes	No	0	3	4
179	R:R:G202	R:R:R205	4.5	No	Yes	0	5	6
180	R:R:G202	R:R:T265	5.46	No	No	0	5	4
181	R:R:A261	R:R:R205	5.53	No	Yes	0	6	6
182	R:R:F206	R:R:L262	8.53	No	No	0	6	6
183	R:R:I207	R:R:I208	4.42	No	No	0	5	5
184	R:R:G209	R:R:P213	4.06	No	Yes	0	6	9
185	R:R:F210	R:R:M214	6.22	No	No	0	8	6
186	R:R:F210	R:R:S255	5.28	No	No	0	8	6
187	R:R:F210	R:R:Q258	14.05	No	No	0	8	8
188	R:R:A212	R:R:P213	3.74	No	Yes	0	5	9
189	R:R:F250	R:R:M214	8.71	No	No	0	9	6
190	R:R:F251	R:R:M214	6.22	No	No	0	6	6
191	R:R:L243	R:R:Y221	19.93	No	Yes	0	7	8
192	R:R:V246	R:R:Y221	3.79	No	Yes	0	8	8
193	R:R:K227	R:R:Q231	6.78	No	No	0	5	5
194	R:R:I228	R:R:I234	10.3	No	No	0	8	4
195	R:R:I228	R:R:L240	4.28	No	No	0	8	6
196	R:R:H229	R:R:L240	6.43	No	No	0	4	6
197	R:R:L233	R:R:Q231	15.97	No	No	0	2	5
198	R:R:I234	R:R:S236	3.1	No	No	0	4	6
199	R:R:I234	R:R:P239	8.47	No	No	0	4	7
200	R:R:R238	R:R:V242	6.54	No	No	0	7	8
201	R:R:M304	R:R:V242	4.56	No	No	0	7	8
202	R:R:L300	R:R:V246	5.96	No	No	0	8	8
203	R:R:V246	R:R:Y301	3.79	No	Yes	0	8	9
204	R:R:F250	R:R:W254	5.01	No	Yes	0	9	9
205	R:R:F251	R:R:L252	3.65	No	No	0	6	6
206	R:R:F251	R:R:S255	17.18	No	No	0	6	6
207	R:R:C253	R:R:N293	9.45	No	No	0	8	9
208	R:R:Q258	R:R:W254	4.38	No	Yes	1	8	9
209	R:R:A290	R:R:W254	5.19	No	Yes	0	8	9
210	R:R:N293	R:R:W254	9.04	No	Yes	0	9	9
211	R:R:A261	R:R:Y257	4	No	Yes	0	6	7
212	R:R:T286	R:R:Y257	7.49	No	Yes	0	7	7
213	R:R:A290	R:R:Y257	4	No	Yes	0	8	7
214	R:R:T286	R:R:V260	6.35	No	No	0	7	5
215	R:R:I263	R:R:R267	3.76	No	Yes	0	5	4
216	R:R:R267	R:R:Y276	19.55	Yes	No	0	4	1
217	R:R:I279	R:R:R267	5.01	No	Yes	0	5	4
218	R:R:I268	R:R:L271	4.28	Yes	No	0	3	1
219	R:R:I268	R:R:L272	5.71	Yes	No	0	3	1
220	R:R:E270	R:R:R269	4.65	No	Yes	0	1	1
221	R:R:Q273	R:R:R269	4.67	No	Yes	0	4	1
222	R:R:E270	R:R:M275	5.41	No	No	8	1	3
223	R:R:E270	R:R:Y276	6.73	No	No	8	1	1
224	R:R:M275	R:R:Y276	9.58	No	No	8	3	1
225	R:R:F291	R:R:S287	6.61	Yes	No	0	7	6
226	R:R:F292	R:R:L289	4.87	Yes	No	0	5	7
227	R:R:C295	R:R:F292	5.59	No	Yes	4	8	5
228	R:R:F292	R:R:L296	3.65	Yes	Yes	4	5	6
229	R:R:N293	R:R:N297	12.26	No	Yes	0	9	9
230	R:R:C295	R:R:L296	3.17	No	Yes	4	8	6
231	R:R:L296	R:R:L300	4.15	Yes	No	0	6	8
232	R:R:N297	R:R:Y301	4.65	Yes	Yes	2	9	9
233	R:R:F303	R:R:V302	5.24	Yes	Yes	2	7	7
234	R:R:F308	R:R:V302	5.24	Yes	Yes	2	9	7
235	R:R:F303	R:R:L312	7.31	Yes	No	0	7	5
236	R:R:D307	R:R:Q306	6.53	No	No	0	6	5
237	R:R:E310	R:R:R311	3.49	No	No	0	5	5
238	R:R:E310	R:R:H314	4.92	No	No	0	5	5
239	R:R:I161	R:R:T157	3.04	No	Yes	0	5	7
240	R:R:F53	R:R:W49	3.01	No	No	0	5	4
241	R:R:F53	R:R:G52	3.01	No	No	0	5	4
242	R:R:F96	R:R:W95	3.01	No	No	0	1	3
243	R:R:K85	R:R:T29	3	Yes	No	0	5	5
244	R:R:L31	R:R:V32	2.98	No	No	0	6	5
245	R:R:L118	R:R:V145	2.98	No	No	0	7	6
246	R:R:L141	R:R:V145	2.98	No	No	0	4	6
247	R:R:L223	R:R:V219	2.98	Yes	No	0	4	5
248	R:R:I146	R:R:I147	2.94	No	No	0	7	3
249	R:R:I281	R:R:K277	2.91	No	No	0	2	3
250	R:R:P182	R:R:R163	2.88	No	No	0	4	5
251	R:R:P239	R:R:R238	2.88	No	No	0	7	7
252	R:R:I281	R:R:L25	2.85	No	No	0	2	2
253	R:R:I107	R:R:L154	2.85	No	No	0	5	3
254	R:R:I216	R:R:L121	2.85	No	No	0	6	6
255	R:R:I204	R:R:L156	2.85	No	Yes	0	3	5
256	R:R:I208	R:R:L156	2.85	No	Yes	0	5	5
257	R:R:I224	R:R:L243	2.85	No	No	0	8	7
258	R:R:I228	R:R:L233	2.85	No	No	0	8	2
259	R:R:L296	R:R:M299	2.83	Yes	No	0	6	7
260	R:R:C176	R:R:F102	2.79	No	Yes	1	9	6
261	R:R:L155	R:R:L156	2.77	No	Yes	0	3	5
262	R:R:A194	R:R:F180	2.77	No	Yes	0	4	5
263	R:R:A86	R:R:Y30	2.67	No	No	0	4	5
264	R:R:A247	R:R:Y221	2.67	No	Yes	0	8	8
265	R:R:F245	R:R:S244	2.64	No	No	0	6	5
266	R:R:F37	R:R:V38	2.62	Yes	No	0	7	5
267	R:R:R54	R:R:V50	2.62	No	No	0	5	7
268	R:R:F93	R:R:V83	2.62	Yes	No	0	7	4
269	R:R:R267	R:R:V266	2.62	Yes	No	0	4	5
270	R:R:F206	R:R:I207	2.51	No	No	0	6	5
271	R:R:F33	R:R:M82	2.49	Yes	No	0	7	7
272	R:R:F245	R:R:M304	2.49	No	No	0	6	7
273	R:R:V125	R:R:W132	2.45	No	Yes	0	5	4
274	R:R:L141	R:R:W132	2.28	No	Yes	0	4	4
275	R:R:R238	R:R:R241	2.13	No	No	0	7	6
276	R:R:G88	R:R:G89	2.11	No	No	0	2	3
277	R:R:G169	R:R:P168	2.03	No	No	0	2	1
278	R:R:A153	R:R:G111	1.95	No	No	0	8	7
279	R:R:A225	R:R:G222	1.95	No	No	0	5	4
280	R:R:G169	R:R:T173	1.82	No	No	0	2	3
281	R:R:G172	R:R:T173	1.82	No	No	0	5	3
282	R:R:P256	R:R:S255	1.78	No	No	0	9	6
283	R:R:P168	R:R:V167	1.77	No	No	0	1	1
284	R:R:G21	R:R:L23	1.71	No	No	0	4	4
285	R:R:G43	R:R:L42	1.71	No	No	0	8	4
286	L:L:C4	R:R:T177	1.69	No	No	0	0	4
287	R:R:L158	R:R:P159	1.64	No	No	0	4	8
288	R:R:S215	R:R:V219	1.62	No	No	0	3	5
289	R:R:A34	R:R:M82	1.61	No	No	0	5	7
290	R:R:S140	R:R:T138	1.6	No	No	0	4	6
291	R:R:T36	R:R:V35	1.59	No	No	0	7	5
292	R:R:G89	R:R:H90	1.59	No	Yes	0	3	4
293	R:R:T199	R:R:V195	1.59	No	Yes	0	3	4
294	R:R:A225	R:R:L240	1.58	No	No	0	5	6
295	R:R:A249	R:R:L300	1.58	No	No	0	7	8
296	R:R:T56	R:R:T58	1.57	No	No	0	7	8
297	R:R:I207	R:R:S211	1.55	No	No	0	5	5
298	R:R:I28	R:R:V32	1.54	No	No	0	5	5
299	R:R:I147	R:R:V151	1.54	No	No	0	3	4
300	R:R:I191	R:R:V195	1.54	No	Yes	0	2	4
301	R:R:I204	R:R:V200	1.54	No	No	0	3	3
302	R:R:I263	R:R:V259	1.54	No	No	0	5	6
303	R:R:I279	R:R:V283	1.54	No	No	0	5	5
304	R:R:H129	R:R:P130	1.53	No	No	0	7	8
305	R:R:K143	R:R:V139	1.52	No	No	0	3	3
306	R:R:I203	R:R:T199	1.52	No	No	0	5	3
307	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
308	R:R:F308	R:R:G305	1.51	Yes	No	0	9	8
309	R:R:K170	R:R:T171	1.5	No	No	0	1	1
310	R:R:N135	R:R:V131	1.48	No	No	0	4	6
311	R:R:L141	R:R:T138	1.47	No	No	0	4	6
312	R:R:L223	R:R:T226	1.47	Yes	No	0	4	4
313	R:R:I27	R:R:L31	1.43	No	No	0	6	6
314	R:R:I161	R:R:L158	1.43	No	No	0	5	4
315	R:R:I313	R:R:L312	1.43	No	No	0	4	5
316	R:R:K188	R:R:N192	1.4	No	No	0	4	3
317	R:R:H129	R:R:V125	1.38	No	No	0	7	5
318	R:R:E278	R:R:I281	1.37	No	No	0	3	2
319	R:R:N135	R:R:Q134	1.32	No	No	0	4	5
320	R:R:R241	R:R:S237	1.32	No	No	0	6	5
321	R:R:R190	R:R:T184	1.29	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.42556	9	1	0
2	R:R:F33	4.642	5	0	7
3	R:R:F37	4.6825	4	0	7
4	R:R:V47	5.445	4	2	9
5	R:R:Y64	5.06	6	2	8
6	R:R:D71	7.066	5	2	9
7	R:R:F74	11.7525	4	1	7
8	R:R:K85	8.1825	4	3	5
9	R:R:H90	5.4025	4	0	4
10	R:R:W91	7.21875	8	1	9
11	R:R:P92	6.74	4	1	2
12	R:R:F93	6.65167	6	1	7
13	R:R:F102	3.9925	4	1	6
14	R:R:D106	8.342	5	1	5
15	R:R:F110	10.1475	4	1	7
16	R:R:I119	5.2075	4	2	9
17	R:R:R123	6.34	4	2	9
18	R:R:C124	3.6925	4	7	8
19	R:R:W132	6.06	4	0	4
20	R:R:R137	7.156	5	5	6
21	R:R:W150	4.37	4	6	9
22	R:R:L156	4.25	4	0	5
23	R:R:T157	5.98	4	1	7
24	R:R:F180	9.972	5	0	5
25	R:R:V195	4.4925	4	0	4
26	R:R:R201	7.37	4	1	5
27	R:R:R205	5.755	4	0	6
28	R:R:P213	4.21	4	0	9
29	R:R:Y221	8.67	5	0	8
30	R:R:L223	3.29	4	7	4
31	R:R:W254	5.16857	7	1	9
32	R:R:Y257	4.935	4	0	7
33	R:R:R267	7.735	4	0	4
34	R:R:I268	4.335	4	0	3
35	R:R:R269	6.1775	4	0	1
36	R:R:F291	8.765	4	1	7
37	R:R:F292	4.5	4	4	5
38	R:R:L296	3.45	4	4	6
39	R:R:N297	6.684	5	2	9
40	R:R:Y301	5.54286	7	2	9
41	R:R:V302	6.2875	4	2	7
42	R:R:F303	5.36	4	2	7
43	R:R:F308	3.965	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:L2	31.3541	5.02	Yes	No	1	0	0
2	L:L:L2	R:R:F102	28.1696	3.65	No	Yes	1	0	6
3	L:L:?1	R:R:W254	100	3.1	Yes	Yes	1	0	9
4	R:R:L109	R:R:W254	32.3702	4.56	No	Yes	1	8	9
5	R:R:F291	R:R:L109	30.4629	4.87	Yes	No	1	7	8
6	R:R:F291	R:R:F33	52.0251	5.36	Yes	Yes	0	7	7
7	R:R:F33	R:R:T29	24.5225	3.89	Yes	No	0	7	5
8	R:R:T29	R:R:V285	13.3284	3.17	No	No	0	5	6
9	R:R:L25	R:R:V285	11.4126	4.47	No	No	0	2	6
10	R:R:F33	R:R:L78	13.5072	7.31	Yes	No	0	7	8
11	R:R:F250	R:R:W254	61.0677	5.01	No	Yes	0	9	9
12	R:R:F250	R:R:I116	62.748	11.3	No	No	0	9	8
13	R:R:I116	R:R:Y301	62.3308	9.67	No	Yes	2	8	9
14	R:R:V246	R:R:Y301	53.5436	3.79	No	Yes	0	8	9
15	R:R:L300	R:R:V246	14.6993	5.96	No	No	0	8	8
16	R:R:L296	R:R:L300	11.8043	4.15	Yes	No	0	6	8
17	R:R:N293	R:R:W254	63.1737	9.04	No	Yes	0	9	9
18	R:R:N293	R:R:N297	62.9921	12.26	No	Yes	0	9	9
19	R:R:N297	R:R:Y301	74.3593	4.65	Yes	Yes	2	9	9
20	R:R:F37	R:R:L78	11.5942	3.65	Yes	No	0	7	8
21	R:R:Y301	R:R:Y64	58.7262	4.96	Yes	Yes	2	9	8
22	R:R:D71	R:R:N297	17.7703	6.73	Yes	Yes	2	9	9
23	R:R:F308	R:R:Y64	19.4363	4.13	Yes	Yes	2	9	8
24	R:R:F308	R:R:M55	17.3332	4.98	Yes	No	0	9	5
25	R:R:M55	R:R:V50	11.6453	4.56	No	No	0	5	7
26	R:R:R54	R:R:V50	10.2092	2.62	No	No	0	5	7
27	R:R:T60	R:R:Y64	37.8935	6.24	No	Yes	0	7	8
28	R:R:R137	R:R:T60	32.4412	3.88	Yes	No	0	6	7
29	R:R:R123	R:R:Y301	39.6361	6.17	Yes	Yes	2	9	9
30	L:L:?1	R:R:D106	21.1421	14.77	Yes	Yes	1	0	5
31	R:R:D106	R:R:T157	22.0674	11.56	Yes	Yes	1	5	7
32	R:R:I107	R:R:T157	17.7447	4.56	No	Yes	0	5	7
33	R:R:I107	R:R:N108	15.0768	5.66	No	No	0	5	8
34	R:R:N108	R:R:W150	12.3861	3.39	No	Yes	0	8	9
35	R:R:F74	R:R:S294	28.3541	5.28	Yes	No	0	7	8
36	R:R:C176	R:R:F102	29.0097	2.79	No	Yes	1	9	6
37	R:R:C176	R:R:W91	24.267	10.45	No	Yes	1	9	9
38	R:R:P92	R:R:W91	14.8611	5.4	Yes	Yes	1	2	9
39	R:R:H90	R:R:P92	12.582	7.63	Yes	Yes	0	4	2
40	L:L:?1	R:R:R201	47.7081	12.12	Yes	Yes	1	0	5
41	R:R:F178	R:R:R201	52.0194	7.48	No	Yes	0	4	5
42	R:R:F178	R:R:F180	50.992	18.22	No	Yes	0	4	5
43	R:R:F180	R:R:R163	17.1033	5.34	Yes	No	0	5	5
44	R:R:P182	R:R:R163	14.4978	2.88	No	No	0	4	5
45	L:L:?1	R:R:F110	16.5669	20.98	Yes	Yes	1	0	7
46	R:R:F110	R:R:L156	12.3861	8.53	Yes	Yes	0	7	5
47	R:R:R123	R:R:Y221	43.4479	10.29	Yes	Yes	0	9	8
48	R:R:V246	R:R:Y221	39.551	3.79	No	Yes	0	8	8
49	R:R:L243	R:R:Y221	73.1218	19.93	No	Yes	0	7	8
50	R:R:I224	R:R:L243	70.8484	2.85	No	No	0	8	7
51	R:R:C124	R:R:I224	68.2996	3.27	Yes	No	0	8	8
52	R:R:C124	R:R:L128	52.6438	3.17	Yes	No	7	8	8
53	R:R:C124	R:R:L223	10.5327	3.17	Yes	Yes	7	8	4
54	R:R:K227	R:R:L128	50.2682	4.23	No	No	0	5	8
55	R:R:R137	R:R:T133	20.2736	3.88	Yes	No	0	6	5
56	R:R:T133	R:R:W132	18.8488	3.64	No	Yes	0	5	4
57	R:R:F180	R:R:L198	32.3674	4.87	Yes	No	0	5	4
58	R:R:I268	R:R:L198	31.1498	4.28	Yes	No	0	3	4
59	R:R:I268	R:R:V195	27.5338	3.07	Yes	Yes	0	3	4
60	R:R:R269	R:R:V195	22.4818	11.77	Yes	Yes	0	1	4
61	R:R:K227	R:R:Q231	45.0685	6.78	No	No	0	5	5
62	R:R:L233	R:R:Q231	42.4602	15.97	No	No	0	2	5
63	R:R:I228	R:R:L233	39.8462	2.85	No	No	0	8	2
64	R:R:I228	R:R:I234	26.6994	10.3	No	No	0	8	4
65	R:R:I228	R:R:L240	10.7456	4.28	No	No	0	8	6
66	R:R:I234	R:R:P239	21.3976	8.47	No	No	0	4	7
67	R:R:P239	R:R:R238	18.7381	2.88	No	No	0	7	7
68	R:R:R238	R:R:V242	10.7257	6.54	No	No	0	7	8
69	R:R:E270	R:R:R269	12.1051	4.65	No	Yes	0	1	1
70	R:R:F291	R:R:F74	25.1298	18.22	Yes	Yes	1	7	7
71	R:R:D71	R:R:S294	28.6209	11.78	Yes	No	0	9	8
72	R:R:L67	R:R:Y301	15.0115	3.52	No	Yes	2	9	9
73	R:R:D71	R:R:L67	14.8497	4.07	Yes	No	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	14.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F110	20.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V113	4.05	1	Yes	No	0	8	0	1
L:L:?1	R:R:R201	12.12	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R205	5.51	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W254	3.1	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y257	4.25	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q258	6.03	1	Yes	No	0	8	0	1
L:L:L2	R:R:F81	3.65	1	No	No	0	6	0	1
L:L:L2	R:R:F102	3.65	1	No	Yes	0	6	0	1
L:L:F3	R:R:R205	7.48	0	No	Yes	0	6	0	1
L:L:F3	R:R:A264	4.16	0	No	No	0	4	0	1
R:R:F102	R:R:F81	4.29	1	Yes	No	6	6	1	1
R:R:F81	R:R:V105	7.87	1	No	No	6	6	1	2
R:R:F102	R:R:V164	5.24	1	Yes	No	6	5	1	2
R:R:D106	R:R:F110	3.58	1	Yes	Yes	5	7	1	1
R:R:D106	R:R:T157	11.56	1	Yes	Yes	5	7	1	2
R:R:D106	R:R:V160	5.84	1	Yes	No	5	4	1	2
R:R:D106	R:R:R201	5.96	1	Yes	Yes	5	5	1	1
R:R:L109	R:R:W254	4.56	1	No	Yes	8	9	2	1
R:R:F110	R:R:F114	7.5	1	Yes	No	7	6	1	2
R:R:F110	R:R:L156	8.53	1	Yes	Yes	7	5	1	2
R:R:P213	R:R:V113	5.3	0	Yes	No	9	8	2	1
R:R:V113	R:R:W254	4.9	1	No	Yes	8	9	1	1
R:R:T157	R:R:V160	4.76	1	Yes	No	7	4	2	2
R:R:R201	R:R:V160	3.92	1	Yes	No	5	4	1	2
R:R:T177	R:R:V167	4.76	0	No	No	4	1	1	2
R:R:F178	R:R:R201	7.48	0	No	Yes	4	5	2	1
R:R:G202	R:R:R205	4.5	0	No	Yes	5	6	2	1
R:R:A261	R:R:R205	5.53	0	No	Yes	6	6	2	1
R:R:F210	R:R:Q258	14.05	0	No	No	8	8	2	1
R:R:F250	R:R:W254	5.01	0	No	Yes	9	9	2	1
R:R:Q258	R:R:W254	4.38	1	No	Yes	8	9	1	1
R:R:A290	R:R:W254	5.19	0	No	Yes	8	9	2	1
R:R:N293	R:R:W254	9.04	0	No	Yes	9	9	2	1
R:R:A261	R:R:Y257	4	0	No	Yes	6	7	2	1
R:R:T286	R:R:Y257	7.49	0	No	Yes	7	7	2	1
R:R:A290	R:R:Y257	4	0	No	Yes	8	7	2	1
R:R:C176	R:R:F102	2.79	1	No	Yes	9	6	2	1
L:L:C4	R:R:T177	1.69	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KFT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	287
Number of Links	321
Number of Hubs	43
Number of Links mediated by Hubs	163
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	78143
Length Of Smallest Path	3
Average Path Length	14.765
Length of Longest Path	34
Minimum Path Strength	1.4
Average Path Strength	6.63521
Maximum Path Strength	18.44
Minimum Path Correlation	0.7
Average Path Correlation	0.931765
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	48.9547
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3241
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • RAGE receptor binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement receptor activity • immune receptor activity • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • chemotaxis • taxis • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • nitric oxide mediated signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of biological process • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of response to stimulus • immune system process • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • intracellular vesicle • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • azurophil granule • primary lysosome • azurophil granule membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • tertiary granule • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	L-N-Formylmethionine N-formyl-L-methionine Formyl-methionine N-Formylmethionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21462
Sequence	>9KFT_nogp_Chain_R A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T H T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G H W P F G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H P V W T Q N H R T V S L A K K V I I G P W V M A L L L T L P V I I R V T T V P G K T G T V A C T F N F S P W T N D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G L I K S S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R I R E L L Q G M Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D F R E R L I H A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6T	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6T (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-		3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVU	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVU (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7EUO	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7EUO (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7VFX	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMIFL	-	Gi1/β1/γ2	2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	7VFX (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMIFL	-		2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	9KFT	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFC	-	Gi1/β1/γ2	3.06	2025-11-12	To be published
	9KFT (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFC	-		3.06	2025-11-12	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KFT_nogp.zip

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