psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M22	4.98	Yes	No	0	3	7
2	R:R:D101	R:R:M22	4.16	No	No	0	2	7
3	R:R:K23	R:R:M26	5.76	No	No	0	4	6
4	R:R:P184	R:R:Y25	20.86	Yes	No	0	5	4
5	R:R:F94	R:R:M26	3.73	Yes	No	0	3	6
6	R:R:H98	R:R:M26	10.51	No	No	0	4	6
7	R:R:I27	R:R:K278	4.36	No	No	0	5	2
8	R:R:H95	R:R:L28	7.71	Yes	No	0	4	6
9	R:R:G30	R:R:P31	4.06	No	No	0	4	4
10	R:R:F283	R:R:Q32	5.86	No	No	0	4	5
11	R:R:F283	R:R:V36	5.24	No	No	0	4	5
12	R:R:A37	R:R:V96	3.39	No	No	0	5	4
13	R:R:L39	R:R:L43	6.92	No	Yes	0	5	6
14	R:R:L39	R:R:M286	4.24	No	No	0	5	5
15	R:R:C40	R:R:M286	3.24	No	No	0	6	5
16	R:R:L289	R:R:L43	5.54	No	Yes	0	6	6
17	R:R:I290	R:R:L43	4.28	No	Yes	0	4	6
18	R:R:L43	R:R:M293	4.24	Yes	No	0	6	6
19	R:R:L46	R:R:M293	4.24	No	No	0	4	6
20	R:R:S47	R:R:S84	4.89	Yes	No	0	7	8
21	R:R:S292	R:R:S47	3.26	No	Yes	0	9	7
22	R:R:M293	R:R:S47	4.6	No	Yes	0	6	7
23	R:R:A48	R:R:S84	3.42	No	No	0	6	8
24	R:R:E50	R:R:P296	11	No	No	0	8	9
25	R:R:D80	R:R:N51	12.12	No	No	0	9	9
26	R:R:F81	R:R:N51	6.04	No	No	0	7	9
27	R:R:N51	R:R:P296	6.52	No	No	0	9	9
28	R:R:A77	R:R:V54	3.39	No	Yes	0	9	9
29	R:R:P296	R:R:V54	3.53	No	Yes	0	9	9
30	R:R:A300	R:R:V54	5.09	No	Yes	0	8	9
31	R:R:G78	R:R:L55	3.42	No	No	0	7	7
32	R:R:S60	R:R:Y56	8.9	No	No	0	5	5
33	R:R:W317	R:R:Y56	4.82	No	No	0	3	5
34	R:R:L64	R:R:S61	12.01	No	Yes	0	8	7
35	R:R:S309	R:R:S61	3.26	No	Yes	0	7	7
36	R:R:K67	R:R:L64	5.64	Yes	No	0	6	8
37	R:R:K67	R:R:P68	3.35	Yes	No	0	6	5
38	R:R:K67	R:R:Y70	11.94	Yes	Yes	2	6	8
39	R:R:E305	R:R:K67	5.4	No	Yes	2	6	6
40	R:R:K142	R:R:P68	3.35	No	No	0	5	5
41	R:R:D130	R:R:S69	4.42	Yes	No	0	9	8
42	R:R:I73	R:R:Y70	4.84	No	Yes	0	8	8
43	R:R:S303	R:R:Y70	7.63	No	Yes	2	8	8
44	R:R:E305	R:R:Y70	5.61	No	Yes	2	6	8
45	R:R:I306	R:R:Y70	4.84	No	Yes	2	8	8
46	R:R:F72	R:R:L126	7.31	Yes	No	0	8	6
47	R:R:D130	R:R:F72	7.17	Yes	Yes	3	9	8
48	R:R:F72	R:R:L145	3.65	Yes	No	3	8	6
49	R:R:F72	R:R:L154	3.65	Yes	No	0	8	8
50	R:R:S123	R:R:S75	4.89	No	No	0	8	9
51	R:R:L154	R:R:S75	9.01	No	No	0	8	9
52	R:R:S75	R:R:W158	6.18	No	Yes	0	9	9
53	R:R:L124	R:R:L76	5.54	No	No	1	8	9
54	R:R:L76	R:R:N295	8.24	No	No	0	9	9
55	R:R:L76	R:R:Y299	4.69	No	Yes	1	9	9
56	R:R:D80	R:R:S292	10.31	No	No	0	9	9
57	R:R:F81	R:R:V85	3.93	No	No	0	7	4
58	R:R:L82	R:R:T116	4.42	No	No	0	7	7
59	R:R:A83	R:R:T116	3.36	No	No	0	8	7
60	R:R:A83	R:R:F117	8.32	No	Yes	0	8	6
61	R:R:S112	R:R:V86	3.23	No	No	0	4	4
62	R:R:F87	R:R:F91	8.57	Yes	Yes	1	6	6
63	R:R:F87	R:R:V113	5.24	Yes	No	1	6	5
64	R:R:F117	R:R:F87	4.29	Yes	Yes	1	6	6
65	R:R:F87	R:R:S285	5.28	Yes	No	1	6	5
66	R:R:F87	R:R:L289	6.09	Yes	No	0	6	6
67	L:L:?1	R:R:F87	11.2	Yes	Yes	1	0	6
68	R:R:K109	R:R:S90	6.12	No	No	0	5	4
69	L:L:?1	R:R:S90	3.94	Yes	No	0	0	4
70	R:R:F91	R:R:H95	13.58	Yes	Yes	1	6	4
71	R:R:F91	R:R:S285	5.28	Yes	No	1	6	5
72	R:R:F91	R:R:M286	6.22	Yes	No	0	6	5
73	L:L:?1	R:R:F91	9.6	Yes	Yes	1	0	6
74	R:R:F97	R:R:N93	3.62	No	No	0	3	3
75	R:R:F94	R:R:H95	9.05	Yes	Yes	1	3	4
76	R:R:F106	R:R:F94	5.36	No	Yes	1	9	3
77	R:R:F94	R:R:P184	5.78	Yes	Yes	1	3	5
78	L:L:?1	R:R:F94	11.99	Yes	Yes	1	0	3
79	L:L:?1	R:R:H95	5.06	Yes	Yes	1	0	4
80	R:R:D101	R:R:G99	5.03	No	No	0	2	5
81	R:R:S102	R:R:V105	4.85	No	No	0	6	4
82	R:R:K103	R:R:L185	5.64	No	No	0	3	4
83	R:R:F106	R:R:I110	5.02	No	No	0	9	4
84	R:R:F106	R:R:P184	4.33	No	Yes	1	9	5
85	R:R:L107	R:R:P168	4.93	No	No	0	5	5
86	R:R:L108	R:R:L169	4.15	No	No	0	4	6
87	R:R:F183	R:R:I110	6.28	Yes	No	0	6	4
88	R:R:I110	R:R:I186	4.42	No	Yes	0	4	5
89	R:R:G111	R:R:T114	3.64	No	Yes	0	6	4
90	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
91	L:L:?1	R:R:V113	7.82	Yes	No	1	0	5
92	R:R:S165	R:R:T114	3.2	No	Yes	0	7	4
93	R:R:T114	R:R:W194	6.06	Yes	Yes	1	4	5
94	L:L:?1	R:R:T114	10.65	Yes	Yes	1	0	4
95	R:R:M115	R:R:W158	5.82	Yes	Yes	0	5	9
96	R:R:A162	R:R:M115	3.22	No	Yes	0	3	5
97	R:R:M115	R:R:S165	4.6	Yes	No	0	5	7
98	R:R:M115	R:R:Y166	11.97	Yes	Yes	0	5	4
99	R:R:F117	R:R:S120	3.96	Yes	No	0	6	9
100	R:R:F117	R:R:W258	7.02	Yes	Yes	1	6	8
101	R:R:C288	R:R:F117	5.59	No	Yes	1	7	6
102	R:R:S161	R:R:T118	3.2	No	No	0	8	6
103	R:R:T118	R:R:W194	6.06	No	Yes	1	6	5
104	R:R:I198	R:R:T118	6.08	No	No	1	7	6
105	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
106	R:R:A119	R:R:S161	3.42	No	No	0	7	8
107	R:R:F202	R:R:V121	3.93	Yes	No	1	7	8
108	R:R:V121	R:R:W258	4.9	No	Yes	1	8	8
109	R:R:G122	R:R:M157	3.49	No	No	0	5	6
110	R:R:L124	R:R:L254	4.15	No	Yes	1	8	9
111	R:R:L124	R:R:Y299	11.72	No	Yes	1	8	9
112	R:R:I129	R:R:L125	4.28	No	No	0	6	6
113	R:R:I205	R:R:L125	5.71	No	No	0	8	6
114	R:R:L126	R:R:T153	4.42	No	No	0	6	6
115	R:R:L126	R:R:M157	5.65	No	No	0	6	6
116	R:R:R131	R:R:T127	5.17	No	No	1	9	9
117	R:R:T127	R:R:Y299	6.24	No	Yes	1	9	9
118	R:R:A128	R:R:T208	3.36	No	No	0	9	6
119	R:R:A128	R:R:Y209	8.01	No	Yes	0	9	9
120	R:R:D130	R:R:Y141	10.34	Yes	No	0	9	7
121	R:R:D130	R:R:L145	8.14	Yes	No	3	9	6
122	R:R:R131	R:R:Y209	8.23	No	Yes	1	9	9
123	R:R:R131	R:R:Y299	9.26	No	Yes	1	9	9
124	R:R:R136	R:R:Y132	14.4	No	No	0	6	8
125	R:R:H211	R:R:Y132	3.27	No	No	0	5	8
126	R:R:V212	R:R:Y132	3.79	No	No	0	9	8
127	R:R:C134	R:R:Y141	8.06	No	No	0	8	7
128	R:R:R136	R:R:Y137	24.69	No	Yes	0	6	5
129	R:R:K215	R:R:R136	8.66	No	No	0	6	6
130	R:R:P138	R:R:P139	7.79	No	No	0	8	7
131	R:R:R149	R:R:T146	5.17	No	No	0	6	9
132	R:R:F197	R:R:V164	11.8	No	No	0	5	5
133	R:R:L169	R:R:Y166	4.69	No	Yes	0	6	4
134	R:R:L167	R:R:P168	4.93	No	No	0	5	5
135	R:R:L167	R:R:W172	5.69	No	No	0	5	5
136	R:R:P168	R:R:Y190	9.74	No	No	0	5	7
137	R:R:R177	R:R:W172	13.99	Yes	No	4	3	5
138	R:R:P187	R:R:W172	8.11	Yes	No	4	4	5
139	R:R:C175	R:R:T173	8.45	No	No	0	3	5
140	R:R:C174	R:R:C179	7.28	No	No	0	5	9
141	R:R:C174	R:R:P187	5.65	No	Yes	0	5	4
142	R:R:P187	R:R:R177	5.76	Yes	Yes	4	4	3
143	R:R:D189	R:R:R177	23.82	No	Yes	0	4	3
144	R:R:I186	R:R:S180	4.64	Yes	No	0	5	4
145	R:R:E181	R:R:T272	4.23	No	No	0	4	1
146	R:R:E181	R:R:L273	9.28	No	Yes	0	4	1
147	R:R:L182	R:R:S268	7.51	No	No	0	4	3
148	R:R:L182	R:R:L273	4.15	No	Yes	0	4	1
149	R:R:F183	R:R:P184	4.33	Yes	Yes	1	6	5
150	R:R:F183	R:R:M265	4.98	Yes	Yes	1	6	6
151	R:R:F183	R:R:F281	6.43	Yes	Yes	1	6	4
152	L:L:?1	R:R:F183	27.19	Yes	Yes	1	0	6
153	L:L:?1	R:R:P184	8.63	Yes	Yes	1	0	5
154	R:R:I186	R:R:P187	5.08	Yes	Yes	0	5	4
155	R:R:I186	R:R:Y190	3.63	Yes	No	0	5	7
156	L:L:?1	R:R:I186	4.69	Yes	Yes	0	0	5
157	R:R:W194	R:R:Y190	7.72	Yes	No	0	5	7
158	R:R:L191	R:R:M265	4.24	No	Yes	0	5	6
159	L:L:?1	R:R:L191	4.54	Yes	No	0	0	5
160	R:R:L192	R:R:L269	4.15	No	No	0	4	3
161	R:R:I198	R:R:W194	15.27	No	Yes	1	7	5
162	R:R:M265	R:R:W194	3.49	Yes	Yes	1	6	5
163	L:L:?1	R:R:W194	8.97	Yes	Yes	1	0	5
164	R:R:L195	R:R:L262	5.54	No	No	0	4	6
165	R:R:L195	R:R:M265	7.07	No	Yes	0	4	6
166	R:R:F197	R:R:L201	8.53	No	No	0	5	7
167	R:R:F202	R:R:I198	3.77	Yes	No	1	7	7
168	R:R:F202	R:R:L254	6.09	Yes	Yes	1	7	9
169	R:R:F202	R:R:W258	6.01	Yes	Yes	1	7	8
170	R:R:H211	R:R:Y207	10.89	No	No	0	5	4
171	R:R:L247	R:R:Y209	10.55	No	Yes	0	8	9
172	R:R:V250	R:R:Y209	5.05	No	Yes	1	8	9
173	R:R:L251	R:R:Y209	5.86	No	Yes	0	7	9
174	R:R:Y209	R:R:Y299	4.96	Yes	Yes	1	9	9
175	R:R:Q218	R:R:W214	3.29	No	No	0	5	3
176	R:R:D240	R:R:H217	8.82	No	No	0	7	5
177	R:R:L239	R:R:V220	4.47	No	No	0	5	5
178	R:R:D240	R:R:M237	5.54	No	No	0	7	4
179	R:R:R302	R:R:T246	5.17	No	No	0	7	8
180	R:R:I298	R:R:L249	7.14	Yes	No	0	9	6
181	R:R:L249	R:R:R302	4.86	No	No	0	6	7
182	R:R:V250	R:R:Y299	8.83	No	Yes	1	8	9
183	R:R:I298	R:R:V253	4.61	Yes	No	0	9	7
184	R:R:L254	R:R:W258	3.42	Yes	Yes	1	9	8
185	R:R:F259	R:R:L255	3.65	No	No	0	5	6
186	R:R:C257	R:R:N291	9.45	No	No	0	8	9
187	R:R:V261	R:R:W258	4.9	No	Yes	1	6	8
188	R:R:L262	R:R:W258	3.42	No	Yes	0	6	8
189	R:R:C288	R:R:W258	7.84	No	Yes	1	7	8
190	R:R:N291	R:R:W258	4.52	No	Yes	0	9	8
191	R:R:L287	R:R:P260	3.28	No	No	0	8	9
192	R:R:C288	R:R:V261	5.12	No	No	1	7	6
193	R:R:F281	R:R:L264	8.53	Yes	No	0	4	4
194	R:R:F281	R:R:M265	3.73	Yes	Yes	1	4	6
195	R:R:K278	R:R:L273	4.23	No	Yes	0	2	1
196	L:L:?1	R:R:S285	7.89	Yes	No	1	0	5
197	R:R:N291	R:R:N295	5.45	No	No	0	9	9
198	R:R:I298	R:R:V294	4.61	Yes	No	0	9	6
199	R:R:I298	R:R:Y299	3.63	Yes	Yes	0	9	9
200	R:R:I306	R:R:S303	6.19	No	No	2	8	8
201	R:R:H316	R:R:W317	13.75	No	No	0	5	3
202	R:R:H217	R:R:W214	3.17	No	No	0	5	3
203	R:R:A244	R:R:L213	3.15	No	No	0	8	6
204	R:R:I58	R:R:V54	3.07	No	Yes	0	8	9
205	R:R:K33	R:R:V96	3.04	No	No	0	5	4
206	R:R:M237	R:R:V220	3.04	No	No	0	4	5
207	R:R:K245	R:R:V241	3.04	No	No	0	7	5
208	R:R:G304	R:R:R307	3	No	No	0	4	8
209	R:R:L28	R:R:V36	2.98	No	No	0	6	5
210	R:R:L108	R:R:V105	2.98	No	No	0	4	4
211	R:R:L201	R:R:V121	2.98	No	No	0	7	8
212	R:R:L247	R:R:V212	2.98	No	No	0	8	9
213	R:R:L301	R:R:V297	2.98	No	No	0	6	6
214	R:R:A282	R:R:H95	2.93	No	Yes	0	4	4
215	R:R:P178	R:R:R177	2.88	No	Yes	0	4	3
216	R:R:E50	R:R:V297	2.85	No	No	0	8	6
217	R:R:I58	R:R:L59	2.85	No	No	0	8	4
218	R:R:I205	R:R:L254	2.85	No	Yes	0	8	9
219	R:R:I206	R:R:L251	2.85	No	No	0	5	7
220	R:R:K215	R:R:L135	2.82	No	No	0	6	9
221	R:R:A35	R:R:F283	2.77	No	No	0	5	4
222	R:R:L151	R:R:L71	2.77	No	No	0	1	4
223	R:R:A150	R:R:F72	2.77	No	Yes	0	7	8
224	R:R:L107	R:R:L185	2.77	No	No	0	5	4
225	R:R:L135	R:R:L243	2.77	No	No	5	9	7
226	R:R:L192	R:R:L196	2.77	No	No	0	4	3
227	R:R:L213	R:R:L247	2.77	No	No	0	6	8
228	R:R:L239	R:R:L243	2.77	No	No	0	5	7
229	R:R:A263	R:R:F259	2.77	No	No	0	5	5
230	R:R:L269	R:R:N188	2.75	No	No	0	3	4
231	R:R:H267	R:R:T271	2.74	No	No	0	4	3
232	R:R:K279	R:R:Q32	2.71	No	No	0	2	5
233	R:R:C313	R:R:Y56	2.69	No	No	0	6	5
234	R:R:A79	R:R:W158	2.59	No	Yes	0	8	9
235	R:R:H219	R:R:L239	2.57	No	No	0	7	5
236	R:R:S69	R:R:Y70	2.54	No	Yes	0	8	8
237	R:R:S140	R:R:Y137	2.54	No	Yes	0	5	5
238	R:R:F197	R:R:L160	2.44	No	No	0	5	4
239	R:R:F281	R:R:L182	2.44	Yes	No	0	4	4
240	R:R:L301	R:R:R307	2.43	No	No	0	6	8
241	R:R:M170	R:R:Y166	2.39	No	Yes	0	4	4
242	R:R:Q63	R:R:R66	2.34	No	No	0	6	7
243	R:R:L133	R:R:Y137	2.34	No	Yes	0	5	5
244	R:R:L133	R:R:Y141	2.34	No	No	0	5	7
245	R:R:L144	R:R:Y137	2.34	No	Yes	0	4	5
246	R:R:H62	R:R:R65	2.26	No	No	0	5	3
247	R:R:H311	R:R:R307	2.26	No	No	0	4	8
248	R:R:A88	R:R:G44	1.95	No	No	0	6	7
249	R:R:A77	R:R:G74	1.95	No	No	0	9	7
250	R:R:C175	R:R:P176	1.88	No	No	0	3	4
251	R:R:G44	R:R:S47	1.86	No	Yes	0	7	7
252	R:R:G30	R:R:K33	1.74	No	No	0	4	5
253	R:R:A104	R:R:S102	1.71	No	No	0	1	6
254	R:R:G204	R:R:L125	1.71	No	No	0	5	6
255	R:R:A270	R:R:T271	1.68	No	No	0	4	3
256	R:R:S60	R:R:S61	1.63	No	Yes	0	5	7
257	R:R:S224	R:R:V220	1.62	No	No	0	4	5
258	R:R:A252	R:R:I256	1.62	No	No	0	5	5
259	R:R:S274	R:R:V277	1.62	No	No	0	2	3
260	R:R:V92	R:R:V96	1.6	No	No	0	5	4
261	R:R:C313	R:R:L57	1.59	No	No	0	6	8
262	R:R:C257	R:R:L287	1.59	No	No	0	8	8
263	R:R:A77	R:R:L55	1.58	No	No	0	9	7
264	R:R:A310	R:R:L57	1.58	No	No	0	6	8
265	R:R:A150	R:R:L71	1.58	No	No	0	7	4
266	R:R:A216	R:R:L135	1.58	No	No	5	8	9
267	R:R:A266	R:R:L195	1.58	No	No	0	5	4
268	R:R:A216	R:R:L243	1.58	No	No	5	8	7
269	R:R:I156	R:R:V152	1.54	No	No	0	3	3
270	R:R:L269	R:R:S268	1.5	No	No	0	3	3
271	R:R:L42	R:R:V38	1.49	No	No	0	4	5
272	R:R:L264	R:R:V277	1.49	No	No	0	4	3
273	R:R:L273	R:R:V277	1.49	Yes	No	0	1	3
274	R:R:N93	R:R:V92	1.48	No	No	0	3	5
275	R:R:L45	R:R:T41	1.47	No	No	0	5	5
276	R:R:C313	R:R:H312	1.47	No	No	0	6	5
277	R:R:Q63	R:R:S61	1.44	No	Yes	0	6	7
278	R:R:P68	R:R:R147	1.44	No	No	0	5	3
279	R:R:F259	R:R:P260	1.44	No	No	0	5	9
280	R:R:K33	R:R:L28	1.41	No	No	0	5	6
281	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
282	R:R:L45	R:R:L49	1.38	No	No	0	5	4
283	R:R:H62	R:R:Q63	1.24	No	No	0	5	6
284	R:R:H226	R:R:Q227	1.24	No	No	0	4	2
285	R:R:F200	R:R:L201	1.22	No	No	0	4	7
286	R:R:D24	R:R:Y25	1.15	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L43	5.245	4	0	6
2	R:R:S47	3.6525	4	0	7
3	R:R:V54	3.77	4	0	9
4	R:R:S61	4.585	4	0	7
5	R:R:K67	6.5825	4	2	6
6	R:R:Y70	6.23333	6	2	8
7	R:R:F72	4.91	5	3	8
8	R:R:F87	6.77833	6	1	6
9	R:R:F91	8.65	5	1	6
10	R:R:F94	6.815	6	1	3
11	R:R:H95	7.666	5	1	4
12	R:R:T114	5.8875	4	1	4
13	R:R:M115	6.4025	4	0	5
14	R:R:F117	5.836	5	1	6
15	R:R:D130	7.5175	4	3	9
16	R:R:Y137	6.66	5	0	5
17	R:R:W158	5.5925	4	0	9
18	R:R:Y166	5.7175	4	0	4
19	R:R:R177	11.6125	4	4	3
20	R:R:F183	9.842	5	1	6
21	R:R:P184	8.786	5	1	5
22	R:R:I186	4.492	5	0	5
23	R:R:P187	6.15	4	4	4
24	R:R:W194	7.92833	6	1	5
25	R:R:F202	4.95	4	1	7
26	R:R:Y209	7.11	6	1	9
27	R:R:L254	4.1275	4	1	9
28	R:R:W258	5.25375	8	1	8
29	R:R:M265	4.702	5	1	6
30	R:R:L273	4.7875	4	0	1
31	R:R:F281	5.2825	4	1	4
32	R:R:I298	4.9975	4	0	9
33	R:R:Y299	7.04714	7	1	9
34	L:L:?1	9.39769	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M22	10.035	4.98	Yes	No	0	3	7
2	R:R:F94	R:R:M26	10.035	3.73	Yes	No	0	3	6
3	R:R:F183	R:R:F281	24.9639	6.43	Yes	Yes	1	6	4
4	R:R:F281	R:R:L182	46.3631	2.44	Yes	No	0	4	4
5	R:R:L182	R:R:L273	21.5949	4.15	No	Yes	0	4	1
6	L:L:?1	R:R:F94	21.8009	11.99	Yes	Yes	1	0	3
7	L:L:?1	R:R:F183	28.7657	27.19	Yes	Yes	1	0	6
8	R:R:H95	R:R:L28	61.1477	7.71	Yes	No	0	4	6
9	R:R:K33	R:R:L28	35.4317	1.41	No	No	0	5	6
10	R:R:F283	R:R:V36	17.8755	5.24	No	No	0	4	5
11	R:R:L28	R:R:V36	22.2955	2.98	No	No	0	6	5
12	R:R:K33	R:R:V96	22.2955	3.04	No	No	0	5	4
13	R:R:F91	R:R:H95	22.1925	13.58	Yes	Yes	1	6	4
14	R:R:F91	R:R:M286	12.3429	6.22	Yes	No	0	6	5
15	L:L:?1	R:R:F87	82.9693	11.2	Yes	Yes	1	0	6
16	R:R:F87	R:R:L289	74.6652	6.09	Yes	No	0	6	6
17	R:R:L289	R:R:L43	72.5118	5.54	No	Yes	0	6	6
18	R:R:L43	R:R:M293	72.8725	4.24	Yes	No	0	6	6
19	R:R:M293	R:R:S47	67.9889	4.6	No	Yes	0	6	7
20	R:R:S292	R:R:S47	55.4193	3.26	No	Yes	0	9	7
21	R:R:E50	R:R:P296	17.484	11	No	No	0	8	9
22	R:R:N51	R:R:P296	42.3346	6.52	No	No	0	9	9
23	R:R:D80	R:R:N51	50.2473	12.12	No	No	0	9	9
24	R:R:D80	R:R:S292	52.8436	10.31	No	No	0	9	9
25	R:R:A77	R:R:V54	11.735	3.39	No	Yes	0	9	9
26	R:R:P296	R:R:V54	23.1506	3.53	No	Yes	0	9	9
27	L:L:?1	R:R:T114	63.2804	10.65	Yes	Yes	1	0	4
28	R:R:S165	R:R:T114	83.845	3.2	No	Yes	0	7	4
29	R:R:M115	R:R:S165	82.6911	4.6	Yes	No	0	5	7
30	R:R:M115	R:R:W158	69.3179	5.82	Yes	Yes	0	5	9
31	R:R:S75	R:R:W158	91.325	6.18	No	Yes	0	9	9
32	R:R:L154	R:R:S75	88.2341	9.01	No	No	0	8	9
33	R:R:F72	R:R:L154	86.7814	3.65	Yes	No	0	8	8
34	R:R:D130	R:R:F72	74.0882	7.17	Yes	Yes	3	9	8
35	R:R:D130	R:R:S69	64.5786	4.42	Yes	No	0	9	8
36	R:R:S69	R:R:Y70	62.2398	2.54	No	Yes	0	8	8
37	R:R:K67	R:R:Y70	50.5564	11.94	Yes	Yes	2	6	8
38	R:R:K67	R:R:L64	40.748	5.64	Yes	No	0	6	8
39	R:R:L64	R:R:S61	38.1311	12.01	No	Yes	0	8	7
40	R:R:S60	R:R:S61	21.9967	1.63	No	Yes	0	5	7
41	R:R:S60	R:R:Y56	19.2355	8.9	No	No	0	5	5
42	R:R:F72	R:R:L126	11.529	7.31	Yes	No	0	8	6
43	R:R:F117	R:R:F87	78.3639	4.29	Yes	Yes	1	6	6
44	R:R:F117	R:R:W258	69.4519	7.02	Yes	Yes	1	6	8
45	R:R:L254	R:R:W258	63.4041	3.42	Yes	Yes	1	9	8
46	R:R:L124	R:R:L254	100	4.15	No	Yes	1	8	9
47	L:L:?1	R:R:W194	33.8038	8.97	Yes	Yes	1	0	5
48	R:R:I198	R:R:W194	51.3909	15.27	No	Yes	1	7	5
49	R:R:F202	R:R:I198	63.4144	3.77	Yes	No	1	7	7
50	R:R:F202	R:R:L254	49.0006	6.09	Yes	Yes	1	7	9
51	R:R:N291	R:R:W258	19.2252	4.52	No	Yes	0	9	8
52	R:R:L124	R:R:Y299	95.2813	11.72	No	Yes	1	8	9
53	R:R:M115	R:R:Y166	23.913	11.97	Yes	Yes	0	5	4
54	R:R:V92	R:R:V96	13.435	1.6	No	No	0	5	4
55	R:R:L169	R:R:Y166	13.4865	4.69	No	Yes	0	6	4
56	R:R:L108	R:R:L169	10.8284	4.15	No	No	0	4	6
57	L:L:?1	R:R:I186	33.2475	4.69	Yes	Yes	0	0	5
58	R:R:I186	R:R:Y190	11.0756	3.63	Yes	No	0	5	7
59	R:R:P168	R:R:Y190	19.0707	9.74	No	No	0	5	7
60	R:R:L107	R:R:P168	11.3641	4.93	No	No	0	5	5
61	R:R:W194	R:R:Y190	23.6658	7.72	Yes	No	0	5	7
62	R:R:T118	R:R:W194	16.2477	6.06	No	Yes	1	6	5
63	R:R:S161	R:R:T118	28.0651	3.2	No	No	0	8	6
64	R:R:A119	R:R:S161	26.9421	3.42	No	No	0	7	8
65	R:R:V121	R:R:W258	11.3435	4.9	No	Yes	1	8	8
66	R:R:F202	R:R:V121	11.7762	3.93	Yes	No	1	7	8
67	R:R:I205	R:R:L254	13.8368	2.85	No	Yes	0	8	9
68	R:R:I205	R:R:L125	10.4059	5.71	No	No	0	8	6
69	R:R:Y209	R:R:Y299	79.0954	4.96	Yes	Yes	1	9	9
70	R:R:D130	R:R:Y141	33.1548	10.34	Yes	No	0	9	7
71	R:R:L247	R:R:Y209	71.1107	10.55	No	Yes	0	8	9
72	R:R:L247	R:R:V212	64.558	2.98	No	No	0	8	9
73	R:R:V212	R:R:Y132	62.5283	3.79	No	No	0	9	8
74	R:R:R136	R:R:Y132	56.7175	14.4	No	No	0	6	8
75	R:R:L133	R:R:Y141	29.8372	2.34	No	No	0	5	7
76	R:R:L133	R:R:Y137	28.5494	2.34	No	Yes	0	5	5
77	R:R:K215	R:R:R136	43.808	8.66	No	No	0	6	6
78	R:R:F197	R:R:L201	11.5702	8.53	No	No	0	5	7
79	R:R:L201	R:R:V121	19.2973	2.98	No	No	0	7	8
80	R:R:I186	R:R:P187	27.1791	5.08	Yes	Yes	0	5	4
81	R:R:P187	R:R:R177	11.3332	5.76	Yes	Yes	4	4	3
82	R:R:L182	R:R:S268	21.6258	7.51	No	No	0	4	3
83	R:R:M265	R:R:W194	36.4826	3.49	Yes	Yes	1	6	5
84	R:R:L269	R:R:S268	17.3398	1.5	No	No	0	3	3
85	R:R:L195	R:R:M265	23.13	7.07	No	Yes	0	4	6
86	R:R:L195	R:R:L262	17.5252	5.54	No	No	0	4	6
87	R:R:L262	R:R:W258	16.9586	3.42	No	Yes	0	6	8
88	R:R:K215	R:R:L135	40.5728	2.82	No	No	0	6	9
89	R:R:L135	R:R:L243	33.876	2.77	No	No	5	9	7
90	R:R:L239	R:R:L243	30.7233	2.77	No	No	0	5	7
91	R:R:L239	R:R:V220	24.0264	4.47	No	No	0	5	5
92	R:R:M237	R:R:V220	17.3501	3.04	No	No	0	4	5
93	R:R:D240	R:R:M237	13.9192	5.54	No	No	0	7	4
94	R:R:D240	R:R:H217	10.4678	8.82	No	No	0	7	5
95	R:R:I298	R:R:Y299	20.4204	3.63	Yes	Yes	0	9	9
96	R:R:I298	R:R:L249	10.3029	7.14	Yes	No	0	9	6
97	R:R:L287	R:R:P260	11.1168	3.28	No	No	0	8	9
98	R:R:C257	R:R:L287	13.8471	1.59	No	No	0	8	8
99	R:R:C257	R:R:N291	16.5568	9.45	No	No	0	8	9
100	R:R:F281	R:R:L264	12.755	8.53	Yes	No	0	4	4
101	R:R:E50	R:R:V297	14.6198	2.85	No	No	0	8	6
102	R:R:L301	R:R:V297	11.735	2.98	No	No	0	6	6
103	R:R:Q63	R:R:S61	11.4877	1.44	No	Yes	0	6	7
104	R:R:C313	R:R:Y56	11.1374	2.69	No	No	0	6	5
105	L:L:?1	R:R:H95	45.137	5.06	Yes	Yes	1	0	4
106	L:L:?1	R:R:P184	10.0247	8.63	Yes	Yes	1	0	5
107	R:R:F281	R:R:M265	37.6571	3.73	Yes	Yes	1	4	6
108	R:R:T114	R:R:W194	22.9652	6.06	Yes	Yes	1	4	5
109	R:R:A119	R:R:W158	25.8912	7.78	No	Yes	0	7	9
110	R:R:R136	R:R:Y137	27.6736	24.69	No	Yes	0	6	5
111	R:R:F87	R:R:F91	19.7507	8.57	Yes	Yes	1	6	6
112	R:R:I198	R:R:T118	13.1259	6.08	No	No	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F94	R:R:M22	4.98	1	Yes	No	3	7	1	2
R:R:P184	R:R:Y25	20.86	1	Yes	No	5	4	1	2
R:R:F94	R:R:M26	3.73	1	Yes	No	3	6	1	2
R:R:H95	R:R:L28	7.71	1	Yes	No	4	6	1	2
R:R:F87	R:R:F91	8.57	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:V113	5.24	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	4.29	1	Yes	Yes	6	6	2	1
R:R:F87	R:R:S285	5.28	1	Yes	No	6	5	1	1
R:R:F87	R:R:L289	6.09	1	Yes	No	6	6	1	2
L:L:?1	R:R:F87	11.2	1	Yes	Yes	0	6	0	1
R:R:K109	R:R:S90	6.12	0	No	No	5	4	2	1
L:L:?1	R:R:S90	3.94	1	Yes	No	0	4	0	1
R:R:F91	R:R:H95	13.58	1	Yes	Yes	6	4	1	1
R:R:F91	R:R:S285	5.28	1	Yes	No	6	5	1	1
R:R:F91	R:R:M286	6.22	1	Yes	No	6	5	1	2
L:L:?1	R:R:F91	9.6	1	Yes	Yes	0	6	0	1
R:R:F94	R:R:H95	9.05	1	Yes	Yes	3	4	1	1
R:R:F106	R:R:F94	5.36	1	No	Yes	9	3	2	1
R:R:F94	R:R:P184	5.78	1	Yes	Yes	3	5	1	1
L:L:?1	R:R:F94	11.99	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H95	5.06	1	Yes	Yes	0	4	0	1
R:R:F106	R:R:I110	5.02	1	No	No	9	4	2	2
R:R:F106	R:R:P184	4.33	1	No	Yes	9	5	2	1
R:R:F183	R:R:I110	6.28	1	Yes	No	6	4	1	2
R:R:I110	R:R:I186	4.42	0	No	Yes	4	5	2	1
R:R:G111	R:R:T114	3.64	0	No	Yes	6	4	2	1
L:L:?1	R:R:V113	7.82	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	3.2	0	No	Yes	7	4	2	1
R:R:T114	R:R:W194	6.06	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:T114	10.65	1	Yes	Yes	0	4	0	1
R:R:T118	R:R:W194	6.06	1	No	Yes	6	5	2	1
R:R:I198	R:R:T118	6.08	1	No	No	7	6	2	2
R:R:I186	R:R:S180	4.64	0	Yes	No	5	4	1	2
R:R:F183	R:R:P184	4.33	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:M265	4.98	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	6.43	1	Yes	Yes	6	4	1	2
L:L:?1	R:R:F183	27.19	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	8.63	1	Yes	Yes	0	5	0	1
R:R:I186	R:R:P187	5.08	0	Yes	Yes	5	4	1	2
R:R:I186	R:R:Y190	3.63	0	Yes	No	5	7	1	2
L:L:?1	R:R:I186	4.69	1	Yes	Yes	0	5	0	1
R:R:W194	R:R:Y190	7.72	1	Yes	No	5	7	1	2
R:R:L191	R:R:M265	4.24	0	No	Yes	5	6	1	2
L:L:?1	R:R:L191	4.54	1	Yes	No	0	5	0	1
R:R:I198	R:R:W194	15.27	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	8.97	1	Yes	Yes	0	5	0	1
R:R:F281	R:R:M265	3.73	1	Yes	Yes	4	6	2	2
L:L:?1	R:R:S285	7.89	1	Yes	No	0	5	0	1
R:R:A282	R:R:H95	2.93	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6KPF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.2
Number of Linked Nodes	258
Number of Links	286
Number of Hubs	34
Number of Links mediated by Hubs	139
Number of Communities	5
Number of Nodes involved in Communities	44
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	38571
Length Of Smallest Path	3
Average Path Length	12.7593
Length of Longest Path	34
Minimum Path Strength	1.34
Average Path Strength	6.22161
Maximum Path Strength	19.545
Minimum Path Correlation	0.7
Average Path Correlation	0.927288
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	53.4788
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.7298
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cannabinoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • metabolic process • regulation of metabolic process • regulation of action potential • negative regulation of action potential • negative regulation of biological process • action potential • regulation of biological quality • regulation of membrane potential • immune response • immune system process • response to amine • response to amphetamine • defense response • response to stress • inflammatory response • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • negative regulation of cellular process • mast cell activation • regulation of mast cell activation • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • cell chemotaxis • chemotaxis • response to external stimulus • leukocyte migration • taxis • cell migration • cell motility • leukocyte chemotaxis • locomotion • trans-synaptic signaling • regulation of signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • chemical synaptic transmission • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • regulation of cell communication • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • negative regulation of synaptic transmission, GABAergic • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dendrite • dendritic tree • endoplasmic reticulum
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8D0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8D0
Name	(6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol
Synonyms
Identifier
Formula	C26 H39 N O3 S
Molecular Weight	445.658
SMILES
PubChem	102336704
Formal Charge	0
Total Atoms	70
Total Chiral Atoms	3
Total Bonds	72
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>6KPF_nogp_Chain_R P M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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