psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M22	3.73	Yes	Yes	1	3	7
2	R:R:D101	R:R:M22	6.93	Yes	Yes	0	2	7
3	R:R:F106	R:R:M22	17.42	No	Yes	1	9	7
4	R:R:M22	R:R:P184	3.35	Yes	No	0	7	5
5	R:R:L185	R:R:M22	4.24	Yes	Yes	1	4	7
6	R:R:H98	R:R:K23	6.55	No	No	0	4	4
7	R:R:F94	R:R:M26	6.22	Yes	No	1	3	6
8	R:R:H95	R:R:M26	9.19	Yes	No	1	4	6
9	R:R:K279	R:R:L28	5.64	No	No	0	2	6
10	R:R:G30	R:R:P31	4.06	No	No	0	4	4
11	R:R:F283	R:R:Q32	5.86	No	No	0	4	5
12	R:R:H95	R:R:V36	5.54	Yes	No	0	4	5
13	R:R:F283	R:R:V36	3.93	No	No	0	4	5
14	R:R:A37	R:R:V96	5.09	No	No	0	5	4
15	R:R:C40	R:R:F91	5.59	No	Yes	1	6	6
16	R:R:C40	R:R:V92	3.42	No	No	0	6	5
17	R:R:C40	R:R:M286	3.24	No	No	1	6	5
18	R:R:I290	R:R:L43	4.28	No	No	0	4	6
19	R:R:L43	R:R:M293	4.24	No	Yes	0	6	6
20	R:R:L46	R:R:M293	5.65	No	Yes	0	4	6
21	R:R:S47	R:R:S84	6.52	No	No	0	7	8
22	R:R:M293	R:R:S47	4.6	Yes	No	0	6	7
23	R:R:E50	R:R:V297	4.28	No	No	0	8	6
24	R:R:D80	R:R:N51	13.46	No	No	0	9	9
25	R:R:N51	R:R:P296	6.52	No	No	0	9	9
26	R:R:F81	R:R:V52	7.87	Yes	No	0	7	5
27	R:R:I58	R:R:V54	3.07	No	Yes	0	8	9
28	R:R:A77	R:R:V54	3.39	No	Yes	0	9	9
29	R:R:P296	R:R:V54	3.53	No	Yes	0	9	9
30	R:R:A300	R:R:V54	3.39	No	Yes	0	8	9
31	R:R:G78	R:R:L55	3.42	No	No	0	7	7
32	R:R:S60	R:R:Y56	8.9	No	No	0	5	5
33	R:R:C313	R:R:Y56	4.03	No	No	0	6	5
34	R:R:W317	R:R:Y56	7.72	No	No	0	3	5
35	R:R:C313	R:R:L57	3.17	No	No	0	6	8
36	R:R:I58	R:R:L64	5.71	No	Yes	0	8	8
37	R:R:Q63	R:R:S61	5.78	No	No	0	6	7
38	R:R:L64	R:R:S61	7.51	Yes	No	0	8	7
39	R:R:S309	R:R:S61	3.26	No	No	0	7	7
40	R:R:L64	R:R:Y70	4.69	Yes	Yes	3	8	8
41	R:R:E305	R:R:L64	7.95	No	Yes	3	6	8
42	R:R:R147	R:R:R65	3.2	Yes	No	0	3	3
43	R:R:R147	R:R:R66	3.2	Yes	No	0	3	7
44	R:R:K67	R:R:P68	3.35	No	No	0	6	5
45	R:R:K67	R:R:Y70	7.17	No	Yes	3	6	8
46	R:R:E305	R:R:K67	8.1	No	No	3	6	6
47	R:R:L145	R:R:P68	3.28	No	No	0	6	5
48	R:R:D130	R:R:S69	4.42	Yes	No	0	9	8
49	R:R:S303	R:R:Y70	7.63	No	Yes	3	8	8
50	R:R:E305	R:R:Y70	4.49	No	Yes	3	6	8
51	R:R:I306	R:R:Y70	6.04	No	Yes	3	8	8
52	R:R:F72	R:R:L126	10.96	No	No	0	8	6
53	R:R:D130	R:R:F72	8.36	Yes	No	0	9	8
54	R:R:A150	R:R:F72	4.16	No	No	0	7	8
55	R:R:S123	R:R:S75	4.89	No	No	0	8	9
56	R:R:L154	R:R:S75	9.01	No	No	0	8	9
57	R:R:L76	R:R:S123	4.5	Yes	No	0	9	8
58	R:R:L124	R:R:L76	5.54	No	Yes	2	8	9
59	R:R:L76	R:R:N295	5.49	Yes	No	2	9	9
60	R:R:L76	R:R:Y299	4.69	Yes	Yes	2	9	9
61	R:R:D80	R:R:S292	8.83	No	No	0	9	9
62	R:R:L82	R:R:T116	4.42	No	No	0	7	7
63	R:R:A83	R:R:T116	3.36	No	No	0	8	7
64	R:R:A83	R:R:F117	4.16	No	Yes	0	8	6
65	R:R:S112	R:R:V86	4.85	No	No	0	4	4
66	R:R:F87	R:R:F91	7.5	Yes	Yes	1	6	6
67	R:R:F87	R:R:V113	3.93	Yes	No	1	6	5
68	R:R:F117	R:R:F87	3.22	Yes	Yes	1	6	6
69	R:R:F87	R:R:L289	7.31	Yes	No	0	6	6
70	L:L:?1	R:R:F87	3.44	Yes	Yes	1	0	6
71	L:L:?1	R:R:S90	3.18	Yes	No	0	0	4
72	R:R:F91	R:R:H95	13.58	Yes	Yes	1	6	4
73	R:R:F91	R:R:M286	3.73	Yes	No	1	6	5
74	R:R:D101	R:R:N93	6.73	Yes	No	0	2	3
75	R:R:F94	R:R:H95	3.39	Yes	Yes	1	3	4
76	L:L:?1	R:R:F94	5.16	Yes	Yes	1	0	3
77	R:R:D101	R:R:G99	3.35	Yes	No	0	2	5
78	R:R:S102	R:R:V105	4.85	No	No	0	6	4
79	R:R:K103	R:R:L185	9.87	No	Yes	0	3	4
80	R:R:F106	R:R:I110	6.28	No	Yes	1	9	4
81	R:R:F106	R:R:L185	3.65	No	Yes	1	9	4
82	R:R:L107	R:R:L169	4.15	No	No	0	5	6
83	R:R:L107	R:R:L185	4.15	No	Yes	0	5	4
84	R:R:F183	R:R:I110	3.77	Yes	Yes	1	6	4
85	R:R:I110	R:R:I186	5.89	Yes	Yes	1	4	5
86	L:L:?1	R:R:I110	12.09	Yes	Yes	1	0	4
87	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
88	L:L:?1	R:R:V113	3.15	Yes	No	1	0	5
89	R:R:S165	R:R:T114	3.2	No	No	0	7	4
90	R:R:T114	R:R:W194	4.85	No	Yes	1	4	5
91	L:L:?1	R:R:T114	16.65	Yes	No	1	0	4
92	R:R:A162	R:R:M115	3.22	No	No	0	3	5
93	R:R:M115	R:R:S165	4.6	No	No	0	5	7
94	R:R:M115	R:R:Y166	8.38	No	Yes	0	5	4
95	R:R:F117	R:R:W258	7.02	Yes	Yes	1	6	8
96	R:R:C288	R:R:F117	8.38	No	Yes	1	7	6
97	L:L:?1	R:R:F117	5.16	Yes	Yes	1	0	6
98	R:R:S161	R:R:T118	3.2	No	No	0	8	6
99	R:R:T118	R:R:W194	3.64	No	Yes	1	6	5
100	R:R:I198	R:R:T118	4.56	No	No	1	7	6
101	R:R:A119	R:R:W158	7.78	No	No	0	7	9
102	R:R:A119	R:R:S161	3.42	No	No	0	7	8
103	R:R:S120	R:R:V121	3.23	No	No	0	9	8
104	R:R:F202	R:R:V121	3.93	Yes	No	1	7	8
105	R:R:V121	R:R:W258	6.13	No	Yes	1	8	8
106	R:R:G122	R:R:M157	3.49	No	No	0	5	6
107	R:R:L124	R:R:N295	4.12	No	No	2	8	9
108	R:R:L124	R:R:Y299	8.21	No	Yes	2	8	9
109	R:R:L126	R:R:T153	4.42	No	No	0	6	6
110	R:R:R131	R:R:T127	3.88	No	No	0	9	9
111	R:R:A128	R:R:T208	3.36	No	No	0	9	6
112	R:R:A128	R:R:Y209	9.34	No	Yes	0	9	9
113	R:R:I129	R:R:T208	4.56	No	No	0	6	6
114	R:R:D130	R:R:Y141	6.9	Yes	Yes	0	9	7
115	R:R:D130	R:R:L145	6.79	Yes	No	0	9	6
116	R:R:R131	R:R:Y209	7.2	No	Yes	2	9	9
117	R:R:R131	R:R:Y299	9.26	No	Yes	2	9	9
118	R:R:R136	R:R:Y132	12.35	No	Yes	0	6	8
119	R:R:H211	R:R:Y132	7.62	No	Yes	0	5	8
120	R:R:C134	R:R:Y141	8.06	No	Yes	0	8	7
121	R:R:L135	R:R:V212	4.47	No	No	0	9	9
122	R:R:R136	R:R:Y137	25.72	No	Yes	0	6	5
123	R:R:K215	R:R:R136	3.71	No	No	0	6	6
124	R:R:L144	R:R:Y137	4.69	No	Yes	0	4	5
125	R:R:P138	R:R:P139	7.79	No	No	0	8	7
126	R:R:K142	R:R:Y141	4.78	No	Yes	0	5	7
127	R:R:L154	R:R:W158	4.56	No	No	0	8	9
128	R:R:M157	R:R:S161	3.07	No	No	0	6	8
129	R:R:F197	R:R:V164	6.55	No	No	0	5	5
130	R:R:L169	R:R:Y166	7.03	No	Yes	0	6	4
131	R:R:L167	R:R:Y190	7.03	No	Yes	0	5	7
132	R:R:I186	R:R:P168	3.39	Yes	No	0	5	5
133	R:R:P187	R:R:W172	14.86	Yes	No	1	4	5
134	R:R:D189	R:R:W172	4.47	No	No	1	4	5
135	R:R:C175	R:R:T173	3.38	No	No	0	3	5
136	R:R:C174	R:R:C179	7.28	No	No	0	5	9
137	R:R:P176	R:R:R177	4.32	No	No	0	4	3
138	R:R:P178	R:R:R177	5.76	No	No	0	4	3
139	R:R:I186	R:R:S180	3.1	Yes	No	0	5	4
140	R:R:N188	R:R:S180	5.96	No	No	0	4	4
141	R:R:E181	R:R:T272	8.47	No	No	0	4	1
142	R:R:L182	R:R:S268	7.51	No	No	0	4	3
143	R:R:F281	R:R:L182	7.31	Yes	No	0	4	4
144	R:R:F183	R:R:I186	3.77	Yes	Yes	1	6	5
145	R:R:F183	R:R:L191	7.31	Yes	No	1	6	5
146	R:R:F183	R:R:M265	3.73	Yes	Yes	1	6	6
147	R:R:F183	R:R:F281	5.36	Yes	Yes	0	6	4
148	L:L:?1	R:R:F183	38.69	Yes	Yes	1	0	6
149	R:R:I186	R:R:P187	5.08	Yes	Yes	1	5	4
150	L:L:?1	R:R:I186	5.04	Yes	Yes	1	0	5
151	R:R:D189	R:R:P187	4.83	No	Yes	1	4	4
152	R:R:P187	R:R:Y190	5.56	Yes	Yes	1	4	7
153	R:R:L269	R:R:N188	10.98	No	No	0	3	4
154	R:R:W194	R:R:Y190	6.75	Yes	Yes	1	5	7
155	L:L:?1	R:R:Y190	3.31	Yes	Yes	1	0	7
156	R:R:L191	R:R:M265	5.65	No	Yes	1	5	6
157	L:L:?1	R:R:L191	3.91	Yes	No	1	0	5
158	R:R:L192	R:R:L269	5.54	No	No	0	4	3
159	R:R:I198	R:R:W194	11.74	No	Yes	1	7	5
160	R:R:M265	R:R:W194	3.49	Yes	Yes	1	6	5
161	L:L:?1	R:R:W194	15.28	Yes	Yes	1	0	5
162	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
163	R:R:F197	R:R:L201	4.87	No	No	0	5	7
164	R:R:F202	R:R:I198	5.02	Yes	No	1	7	7
165	R:R:F202	R:R:W258	6.01	Yes	Yes	1	7	8
166	R:R:F202	R:R:L262	3.65	Yes	No	0	7	6
167	R:R:L247	R:R:Y209	8.21	No	Yes	0	8	9
168	R:R:V250	R:R:Y209	5.05	No	Yes	2	8	9
169	R:R:L251	R:R:Y209	8.21	No	Yes	0	7	9
170	R:R:Y209	R:R:Y299	4.96	Yes	Yes	2	9	9
171	R:R:H211	R:R:K215	10.48	No	No	0	5	6
172	R:R:L247	R:R:V212	4.47	No	No	0	8	9
173	R:R:L213	R:R:L247	4.15	No	No	0	6	8
174	R:R:Q218	R:R:W214	12.05	No	No	0	5	3
175	R:R:K215	R:R:Q218	6.78	No	No	0	6	5
176	R:R:D240	R:R:H217	6.3	No	No	0	7	5
177	R:R:L239	R:R:V220	4.47	No	No	0	5	5
178	R:R:D240	R:R:V220	10.22	No	No	0	7	5
179	R:R:K245	R:R:V241	4.55	No	No	0	7	5
180	R:R:R302	R:R:T246	18.11	No	No	0	7	8
181	R:R:I298	R:R:L249	4.28	Yes	No	0	9	6
182	R:R:L249	R:R:R302	6.07	No	No	0	6	7
183	R:R:V250	R:R:Y299	8.83	No	Yes	2	8	9
184	R:R:V253	R:R:V294	4.81	No	No	2	7	6
185	R:R:I298	R:R:V253	4.61	Yes	No	2	9	7
186	R:R:L254	R:R:L255	4.15	No	No	0	9	6
187	R:R:L254	R:R:W258	3.42	No	Yes	0	9	8
188	R:R:C257	R:R:L287	4.76	No	No	0	8	8
189	R:R:C257	R:R:N291	7.87	No	No	0	8	9
190	R:R:C288	R:R:W258	3.92	No	Yes	1	7	8
191	R:R:N291	R:R:W258	7.91	No	Yes	0	9	8
192	R:R:F259	R:R:P260	4.33	No	No	0	5	9
193	R:R:A263	R:R:F259	6.93	No	No	0	5	5
194	R:R:L287	R:R:P260	3.28	No	No	0	8	9
195	R:R:F281	R:R:V261	3.93	Yes	No	0	4	6
196	R:R:F281	R:R:L264	6.09	Yes	No	0	4	4
197	R:R:H267	R:R:T271	4.11	No	No	0	4	3
198	R:R:L273	R:R:V277	7.45	Yes	No	0	1	3
199	R:R:K279	R:R:Q276	6.78	No	No	0	2	3
200	R:R:F283	R:R:K279	4.96	No	No	0	4	2
201	L:L:?1	R:R:S285	6.36	Yes	No	0	0	5
202	R:R:L289	R:R:M286	5.65	No	No	0	6	5
203	R:R:L289	R:R:S292	6.01	No	No	0	6	9
204	R:R:N291	R:R:N295	5.45	No	No	0	9	9
205	R:R:I298	R:R:V294	3.07	Yes	No	2	9	6
206	R:R:I306	R:R:S303	6.19	No	No	3	8	8
207	R:R:K318	R:R:L314	8.46	No	No	0	4	6
208	R:R:H316	R:R:W317	12.7	No	No	0	5	3
209	R:R:K109	R:R:V105	3.04	No	No	0	5	4
210	R:R:I156	R:R:T153	3.04	No	No	0	3	6
211	R:R:M237	R:R:V241	3.04	No	No	0	4	5
212	R:R:L108	R:R:S112	3	No	No	0	4	4
213	R:R:L144	R:R:S140	3	No	No	0	4	5
214	R:R:G304	R:R:R307	3	No	No	0	4	8
215	R:R:L42	R:R:V38	2.98	No	No	0	4	5
216	R:R:D275	R:R:S274	2.94	No	No	0	3	2
217	R:R:A282	R:R:H95	2.93	No	Yes	0	4	4
218	R:R:I27	R:R:K278	2.91	No	No	0	5	2
219	R:R:G111	R:R:Y166	2.9	No	Yes	0	6	4
220	R:R:I58	R:R:L59	2.85	No	No	0	8	4
221	R:R:I129	R:R:L125	2.85	No	Yes	0	6	6
222	R:R:I205	R:R:L125	2.85	No	Yes	0	8	6
223	R:R:I205	R:R:L254	2.85	No	No	0	8	9
224	R:R:I206	R:R:L251	2.85	No	No	0	5	7
225	R:R:P184	R:R:Y25	2.78	No	No	0	5	4
226	R:R:L42	R:R:L43	2.77	No	No	0	4	6
227	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
228	R:R:L151	R:R:L71	2.77	No	No	0	1	4
229	R:R:D101	R:R:K109	2.77	Yes	No	0	2	5
230	R:R:L125	R:R:L201	2.77	Yes	No	0	6	7
231	R:R:E50	R:R:M293	2.71	No	Yes	0	8	6
232	R:R:F81	R:R:S84	2.64	Yes	No	0	7	8
233	R:R:F81	R:R:V85	2.62	Yes	No	0	7	4
234	R:R:F97	R:R:V92	2.62	No	No	0	3	5
235	R:R:C174	R:R:W172	2.61	No	No	0	5	5
236	R:R:A79	R:R:W158	2.59	No	No	0	8	9
237	R:R:R149	R:R:T146	2.59	No	No	0	6	9
238	R:R:H219	R:R:L239	2.57	No	No	0	7	5
239	R:R:H267	R:R:L273	2.57	No	Yes	0	4	1
240	R:R:H311	R:R:L314	2.57	No	No	0	4	6
241	R:R:T208	R:R:Y132	2.5	No	Yes	0	6	8
242	R:R:F81	R:R:L82	2.44	Yes	No	0	7	7
243	R:R:I73	R:R:Y70	2.42	No	Yes	0	8	8
244	R:R:I298	R:R:Y299	2.42	Yes	Yes	2	9	9
245	R:R:L133	R:R:Y132	2.34	No	Yes	0	5	8
246	R:R:L133	R:R:Y137	2.34	No	Yes	0	5	5
247	R:R:L133	R:R:Y141	2.34	No	Yes	0	5	7
248	R:R:A77	R:R:G74	1.95	No	No	0	9	7
249	R:R:C175	R:R:P176	1.88	No	No	0	3	4
250	R:R:G30	R:R:S29	1.86	No	No	0	4	7
251	R:R:G44	R:R:S47	1.86	No	No	0	7	7
252	R:R:G304	R:R:S303	1.86	No	No	0	4	8
253	R:R:G148	R:R:T146	1.82	No	No	0	4	9
254	R:R:G171	R:R:M170	1.75	No	No	0	4	4
255	R:R:C89	R:R:V85	1.71	No	No	0	7	4
256	R:R:G204	R:R:L125	1.71	No	Yes	0	5	6
257	R:R:A37	R:R:V92	1.7	No	No	0	5	5
258	R:R:A270	R:R:T271	1.68	No	No	0	4	3
259	R:R:S308	R:R:S309	1.63	No	No	0	4	7
260	R:R:T41	R:R:V38	1.59	No	No	0	5	5
261	R:R:A48	R:R:L45	1.58	No	No	0	6	5
262	R:R:A77	R:R:L55	1.58	No	No	0	9	7
263	R:R:A310	R:R:L57	1.58	No	No	0	6	8
264	R:R:A150	R:R:L71	1.58	No	No	0	7	4
265	R:R:A216	R:R:L135	1.58	No	No	0	8	9
266	R:R:A266	R:R:L195	1.58	No	No	0	5	4
267	R:R:A244	R:R:L213	1.58	No	No	0	8	6
268	R:R:A216	R:R:L243	1.58	No	No	0	8	7
269	R:R:A216	R:R:D240	1.54	No	No	0	8	7
270	R:R:K33	R:R:V96	1.52	No	No	0	5	4
271	R:R:L273	R:R:S268	1.5	Yes	No	0	1	3
272	R:R:L39	R:R:V38	1.49	No	No	0	5	5
273	R:R:P68	R:R:R147	1.44	No	Yes	0	5	3
274	R:R:I306	R:R:L57	1.43	No	No	0	8	8
275	R:R:L167	R:R:M170	1.41	No	No	0	5	4
276	R:R:L169	R:R:M170	1.41	No	No	0	6	4
277	R:R:K278	R:R:L182	1.41	No	No	0	2	4
278	R:R:K278	R:R:L273	1.41	No	Yes	0	2	1
279	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
280	R:R:H219	R:R:S222	1.39	No	No	0	7	3
281	R:R:L45	R:R:L49	1.38	No	No	0	5	4
282	R:R:L192	R:R:L196	1.38	No	No	0	4	3
283	R:R:R147	R:R:T146	1.29	Yes	No	0	3	9
284	R:R:H219	R:R:L223	1.29	No	No	0	7	6
285	R:R:H226	R:R:L223	1.29	No	No	0	4	6
286	R:R:H62	R:R:Q63	1.24	No	No	0	5	6
287	R:R:H226	R:R:Q227	1.24	No	No	0	4	2
288	R:R:F197	R:R:L160	1.22	No	No	0	5	4
289	R:R:F200	R:R:L201	1.22	No	No	0	4	7
290	R:R:L301	R:R:R307	1.21	No	No	0	6	8
291	R:R:D24	R:R:Y25	1.15	No	No	0	4	4
292	R:R:E181	R:R:Y25	1.12	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M22	7.134	5	1	7
2	R:R:V54	3.345	4	0	9
3	R:R:L64	6.465	4	3	8
4	R:R:Y70	5.40667	6	3	8
5	R:R:L76	5.055	4	2	9
6	R:R:F81	3.668	5	0	7
7	R:R:F87	5.08	5	1	6
8	R:R:F91	7.6	4	1	6
9	R:R:F94	4.625	4	1	3
10	R:R:H95	6.926	5	1	4
11	R:R:D101	4.945	4	0	2
12	R:R:I110	7.0075	4	1	4
13	R:R:F117	5.588	5	1	6
14	R:R:L125	2.545	4	0	6
15	R:R:D130	6.6175	4	0	9
16	R:R:Y132	6.2025	4	0	8
17	R:R:Y137	8.535	4	0	5
18	R:R:Y141	5.52	4	0	7
19	R:R:R147	2.2825	4	0	3
20	R:R:Y166	5.5325	4	0	4
21	R:R:F183	10.4383	6	1	6
22	R:R:L185	5.4775	4	1	4
23	R:R:I186	4.37833	6	1	5
24	R:R:P187	7.5825	4	1	4
25	R:R:Y190	5.6625	4	1	7
26	R:R:W194	7.625	6	1	5
27	R:R:F202	4.6525	4	1	7
28	R:R:Y209	7.16167	6	2	9
29	R:R:W258	5.735	6	1	8
30	R:R:M265	4.63	4	1	6
31	R:R:L273	3.2325	4	0	1
32	R:R:F281	5.6725	4	0	4
33	R:R:M293	4.3	4	0	6
34	R:R:I298	3.595	4	2	9
35	R:R:Y299	6.395	6	2	9
36	L:L:?1	9.34	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D101	R:R:M22	11.1952	6.93	Yes	Yes	0	2	7
2	R:R:F94	R:R:M22	23.2078	3.73	Yes	Yes	1	3	7
3	R:R:F94	R:R:H95	11.5266	3.39	Yes	Yes	1	3	4
4	R:R:H95	R:R:V36	16.895	5.54	Yes	No	0	4	5
5	R:R:F283	R:R:V36	14.1058	3.93	No	No	0	4	5
6	R:R:F91	R:R:H95	12.8134	13.58	Yes	Yes	1	6	4
7	L:L:?1	R:R:F94	33.8396	5.16	Yes	Yes	1	0	3
8	L:L:?1	R:R:F117	76.019	5.16	Yes	Yes	1	0	6
9	R:R:A83	R:R:F117	38.7385	4.16	No	Yes	0	8	6
10	R:R:A83	R:R:T116	37.1755	3.36	No	No	0	8	7
11	R:R:L82	R:R:T116	35.6015	4.42	No	No	0	7	7
12	R:R:F81	R:R:L82	34.0163	2.44	Yes	No	0	7	7
13	R:R:F81	R:R:S84	22.6113	2.64	Yes	No	0	7	8
14	R:R:S47	R:R:S84	20.9378	6.52	No	No	0	7	8
15	R:R:M293	R:R:S47	17.5577	4.6	Yes	No	0	6	7
16	R:R:L43	R:R:M293	10.665	4.24	No	Yes	0	6	6
17	R:R:D80	R:R:S292	46.4376	8.83	No	No	0	9	9
18	R:R:L289	R:R:S292	47.4705	6.01	No	No	0	6	9
19	R:R:F87	R:R:L289	44.8746	7.31	Yes	No	0	6	6
20	L:L:?1	R:R:F87	29.4378	3.44	Yes	Yes	1	0	6
21	R:R:D80	R:R:N51	45.4766	13.46	No	No	0	9	9
22	R:R:N51	R:R:P296	44.7089	6.52	No	No	0	9	9
23	R:R:P296	R:R:V54	44.002	3.53	No	Yes	0	9	9
24	R:R:I58	R:R:V54	40.9864	3.07	No	Yes	0	8	9
25	R:R:I58	R:R:L64	40.7655	5.71	No	Yes	0	8	8
26	R:R:L64	R:R:Y70	26.8088	4.69	Yes	Yes	3	8	8
27	R:R:I306	R:R:Y70	11.8414	6.04	No	Yes	3	8	8
28	R:R:I306	R:R:L57	10.5766	1.43	No	No	0	8	8
29	R:R:L64	R:R:S61	10.0464	7.51	Yes	No	0	8	7
30	R:R:E305	R:R:L64	14.0506	7.95	No	Yes	3	6	8
31	R:R:K67	R:R:Y70	19.8277	7.17	No	Yes	3	6	8
32	R:R:K67	R:R:P68	31.9507	3.35	No	No	0	6	5
33	R:R:P68	R:R:R147	15.7683	1.44	No	Yes	0	5	3
34	R:R:E305	R:R:K67	13.5093	8.1	No	No	3	6	6
35	R:R:F117	R:R:W258	100	7.02	Yes	Yes	1	6	8
36	R:R:L254	R:R:W258	44.2947	3.42	No	Yes	0	9	8
37	R:R:I205	R:R:L254	42.3837	2.85	No	No	0	8	9
38	R:R:I205	R:R:L125	41.8591	2.85	No	Yes	0	8	6
39	R:R:I129	R:R:L125	38.9484	2.85	No	Yes	0	6	6
40	R:R:I129	R:R:T208	38.6336	4.56	No	No	0	6	6
41	R:R:T208	R:R:Y132	54.3301	2.5	No	Yes	0	6	8
42	R:R:L133	R:R:Y132	40.4341	2.34	No	Yes	0	5	8
43	R:R:L133	R:R:Y141	36.6564	2.34	No	Yes	0	5	7
44	R:R:D130	R:R:Y141	33.7733	6.9	Yes	Yes	0	9	7
45	R:R:D130	R:R:L145	24.9089	6.79	Yes	No	0	9	6
46	R:R:D130	R:R:F72	11.985	8.36	Yes	No	0	9	8
47	R:R:N291	R:R:W258	66.1107	7.91	No	Yes	0	9	8
48	R:R:N291	R:R:N295	63.1282	5.45	No	No	0	9	9
49	R:R:L76	R:R:N295	32.4809	5.49	Yes	No	2	9	9
50	L:L:?1	R:R:W194	12.587	15.28	Yes	Yes	1	0	5
51	R:R:L124	R:R:N295	30.5368	4.12	No	No	2	8	9
52	R:R:L76	R:R:Y299	33.3039	4.69	Yes	Yes	2	9	9
53	R:R:L124	R:R:Y299	30.0729	8.21	No	Yes	2	8	9
54	L:L:?1	R:R:T114	12.7803	16.65	Yes	No	1	0	4
55	R:R:S165	R:R:T114	12.2004	3.2	No	No	0	7	4
56	R:R:M115	R:R:S165	10.6153	4.6	No	No	0	5	7
57	R:R:A128	R:R:T208	22.0424	3.36	No	No	0	9	6
58	R:R:A128	R:R:Y209	22.65	9.34	No	Yes	0	9	9
59	R:R:Y209	R:R:Y299	48.0007	4.96	Yes	Yes	2	9	9
60	R:R:R136	R:R:Y132	12.6643	12.35	No	Yes	0	6	8
61	R:R:L247	R:R:Y209	40.1193	8.21	No	Yes	0	8	9
62	R:R:L247	R:R:V212	32.7074	4.47	No	No	0	8	9
63	L:L:?1	R:R:Y190	13.2608	3.31	Yes	Yes	1	0	7
64	L:L:?1	R:R:I186	16.4476	5.04	Yes	Yes	1	0	5
65	L:L:?1	R:R:F183	29.2721	38.69	Yes	Yes	1	0	6
66	R:R:F183	R:R:F281	28.7639	5.36	Yes	Yes	0	6	4
67	R:R:F281	R:R:L182	24.0362	7.31	Yes	No	0	4	4
68	R:R:L182	R:R:S268	10.3446	7.51	No	No	0	4	3
69	R:R:L135	R:R:V212	30.222	4.47	No	No	0	9	9
70	R:R:A216	R:R:L135	27.9189	1.58	No	No	0	8	9
71	R:R:A216	R:R:D240	22.893	1.54	No	No	0	8	7
72	R:R:D240	R:R:V220	18.0714	10.22	No	No	0	7	5
73	R:R:L239	R:R:V220	15.5252	4.47	No	No	0	5	5
74	R:R:I298	R:R:Y299	15.1221	2.42	Yes	Yes	2	9	9
75	R:R:C257	R:R:N291	10.9025	7.87	No	No	0	8	9
76	R:R:H267	R:R:L273	10.4164	2.57	No	Yes	0	4	1
77	R:R:K278	R:R:L182	12.0678	1.41	No	No	0	2	4
78	R:R:H219	R:R:L239	12.9681	2.57	No	No	0	7	5
79	R:R:F87	R:R:F91	19.176	7.5	Yes	Yes	1	6	6
80	R:R:F117	R:R:F87	30.1778	3.22	Yes	Yes	1	6	6
81	R:R:L145	R:R:P68	24.1356	3.28	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F94	R:R:M22	3.73	1	Yes	Yes	3	7	1	2
R:R:F106	R:R:M22	17.42	1	No	Yes	9	7	2	2
R:R:F94	R:R:M26	6.22	1	Yes	No	3	6	1	2
R:R:H95	R:R:M26	9.19	1	Yes	No	4	6	2	2
R:R:A83	R:R:F117	4.16	0	No	Yes	8	6	2	1
R:R:F87	R:R:F91	7.5	1	Yes	Yes	6	6	1	2
R:R:F87	R:R:V113	3.93	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	3.22	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:L289	7.31	1	Yes	No	6	6	1	2
L:L:?1	R:R:F87	3.44	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S90	3.18	1	Yes	No	0	4	0	1
R:R:F91	R:R:H95	13.58	1	Yes	Yes	6	4	2	2
R:R:F94	R:R:H95	3.39	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:F94	5.16	1	Yes	Yes	0	3	0	1
R:R:F106	R:R:I110	6.28	1	No	Yes	9	4	2	1
R:R:F183	R:R:I110	3.77	1	Yes	Yes	6	4	1	1
R:R:I110	R:R:I186	5.89	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:I110	12.09	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V113	3.15	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	3.2	0	No	No	7	4	2	1
R:R:T114	R:R:W194	4.85	1	No	Yes	4	5	1	1
L:L:?1	R:R:T114	16.65	1	Yes	No	0	4	0	1
R:R:F117	R:R:W258	7.02	1	Yes	Yes	6	8	1	2
R:R:C288	R:R:F117	8.38	1	No	Yes	7	6	2	1
L:L:?1	R:R:F117	5.16	1	Yes	Yes	0	6	0	1
R:R:T118	R:R:W194	3.64	1	No	Yes	6	5	2	1
R:R:I198	R:R:T118	4.56	1	No	No	7	6	2	2
R:R:L167	R:R:Y190	7.03	0	No	Yes	5	7	2	1
R:R:I186	R:R:P168	3.39	1	Yes	No	5	5	1	2
R:R:I186	R:R:S180	3.1	1	Yes	No	5	4	1	2
R:R:F183	R:R:I186	3.77	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:L191	7.31	1	Yes	No	6	5	1	1
R:R:F183	R:R:M265	3.73	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	5.36	1	Yes	Yes	6	4	1	2
L:L:?1	R:R:F183	38.69	1	Yes	Yes	0	6	0	1
R:R:I186	R:R:P187	5.08	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:I186	5.04	1	Yes	Yes	0	5	0	1
R:R:P187	R:R:Y190	5.56	1	Yes	Yes	4	7	2	1
R:R:W194	R:R:Y190	6.75	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:Y190	3.31	1	Yes	Yes	0	7	0	1
R:R:L191	R:R:M265	5.65	1	No	Yes	5	6	1	2
L:L:?1	R:R:L191	3.91	1	Yes	No	0	5	0	1
R:R:I198	R:R:W194	11.74	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	15.28	1	Yes	Yes	0	5	0	1
R:R:C288	R:R:W258	3.92	1	No	Yes	7	8	2	2
L:L:?1	R:R:S285	6.36	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	261
Number of Links	292
Number of Hubs	36
Number of Links mediated by Hubs	141
Number of Communities	3
Number of Nodes involved in Communities	46
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	46330
Length Of Smallest Path	3
Average Path Length	12.9587
Length of Longest Path	29
Minimum Path Strength	1.135
Average Path Strength	5.60038
Maximum Path Strength	27.67
Minimum Path Correlation	0.7
Average Path Correlation	0.923971
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	51.8342
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.039
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KNF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KNF
Name	Olorinab
Synonyms	(2~{S},4~{S})-~{N}-[(2~{S})-3,3-dimethyl-1-oxidanyl-butan-2-yl]-9-(4-oxidanylpyrazin-2-yl)-8,9-diazatricyclo[4.3.0.0^{2,4}]nona-1(6),7-diene-7-carboxamide
Identifier
Formula	C18 H23 N5 O3
Molecular Weight	357.407
SMILES
PubChem	60164925
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	3
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUQ_nogp_Chain_R P M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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