psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M22	3.73	Yes	Yes	1	3	7
2	R:R:D101	R:R:M22	6.93	Yes	Yes	0	2	7
3	R:R:F106	R:R:M22	17.42	No	Yes	1	9	7
4	R:R:M22	R:R:P184	3.35	Yes	No	0	7	5
5	R:R:L185	R:R:M22	4.24	Yes	Yes	1	4	7
6	R:R:H98	R:R:K23	6.55	No	No	0	4	4
7	R:R:F94	R:R:M26	6.22	Yes	No	1	3	6
8	R:R:H95	R:R:M26	9.19	Yes	No	1	4	6
9	R:R:K279	R:R:L28	5.64	No	No	0	2	6
10	R:R:G30	R:R:P31	4.06	No	No	0	4	4
11	R:R:F283	R:R:Q32	5.86	No	No	0	4	5
12	R:R:H95	R:R:V36	5.54	Yes	No	0	4	5
13	R:R:F283	R:R:V36	3.93	No	No	0	4	5
14	R:R:A37	R:R:V96	5.09	No	No	0	5	4
15	R:R:C40	R:R:F91	5.59	No	Yes	1	6	6
16	R:R:C40	R:R:V92	3.42	No	No	0	6	5
17	R:R:C40	R:R:M286	3.24	No	No	1	6	5
18	R:R:I290	R:R:L43	4.28	No	No	0	4	6
19	R:R:L43	R:R:M293	4.24	No	Yes	0	6	6
20	R:R:L46	R:R:M293	5.65	No	Yes	0	4	6
21	R:R:S47	R:R:S84	6.52	No	No	0	7	8
22	R:R:M293	R:R:S47	4.6	Yes	No	0	6	7
23	R:R:E50	R:R:V297	4.28	No	No	0	8	6
24	R:R:D80	R:R:N51	13.46	No	No	0	9	9
25	R:R:N51	R:R:P296	6.52	No	No	0	9	9
26	R:R:F81	R:R:V52	7.87	Yes	No	0	7	5
27	R:R:I58	R:R:V54	3.07	No	Yes	0	8	9
28	R:R:A77	R:R:V54	3.39	No	Yes	0	9	9
29	R:R:P296	R:R:V54	3.53	No	Yes	0	9	9
30	R:R:A300	R:R:V54	3.39	No	Yes	0	8	9
31	R:R:G78	R:R:L55	3.42	No	No	0	7	7
32	R:R:S60	R:R:Y56	8.9	No	No	0	5	5
33	R:R:C313	R:R:Y56	4.03	No	No	0	6	5
34	R:R:W317	R:R:Y56	7.72	No	No	0	3	5
35	R:R:C313	R:R:L57	3.17	No	No	0	6	8
36	R:R:I58	R:R:L64	5.71	No	Yes	0	8	8
37	R:R:Q63	R:R:S61	5.78	No	No	0	6	7
38	R:R:L64	R:R:S61	7.51	Yes	No	0	8	7
39	R:R:S309	R:R:S61	3.26	No	No	0	7	7
40	R:R:L64	R:R:Y70	4.69	Yes	Yes	3	8	8
41	R:R:E305	R:R:L64	7.95	No	Yes	3	6	8
42	R:R:R147	R:R:R65	3.2	Yes	No	0	3	3
43	R:R:R147	R:R:R66	3.2	Yes	No	0	3	7
44	R:R:K67	R:R:P68	3.35	No	No	0	6	5
45	R:R:K67	R:R:Y70	7.17	No	Yes	3	6	8
46	R:R:E305	R:R:K67	8.1	No	No	3	6	6
47	R:R:L145	R:R:P68	3.28	No	No	0	6	5
48	R:R:D130	R:R:S69	4.42	Yes	No	0	9	8
49	R:R:S303	R:R:Y70	7.63	No	Yes	3	8	8
50	R:R:E305	R:R:Y70	4.49	No	Yes	3	6	8
51	R:R:I306	R:R:Y70	6.04	No	Yes	3	8	8
52	R:R:F72	R:R:L126	10.96	No	No	0	8	6
53	R:R:D130	R:R:F72	8.36	Yes	No	0	9	8
54	R:R:A150	R:R:F72	4.16	No	No	0	7	8
55	R:R:S123	R:R:S75	4.89	No	No	0	8	9
56	R:R:L154	R:R:S75	9.01	No	No	0	8	9
57	R:R:L76	R:R:S123	4.5	Yes	No	0	9	8
58	R:R:L124	R:R:L76	5.54	No	Yes	2	8	9
59	R:R:L76	R:R:N295	5.49	Yes	No	2	9	9
60	R:R:L76	R:R:Y299	4.69	Yes	Yes	2	9	9
61	R:R:D80	R:R:S292	8.83	No	No	0	9	9
62	R:R:L82	R:R:T116	4.42	No	No	0	7	7
63	R:R:A83	R:R:T116	3.36	No	No	0	8	7
64	R:R:A83	R:R:F117	4.16	No	Yes	0	8	6
65	R:R:S112	R:R:V86	4.85	No	No	0	4	4
66	R:R:F87	R:R:F91	7.5	Yes	Yes	1	6	6
67	R:R:F87	R:R:V113	3.93	Yes	No	1	6	5
68	R:R:F117	R:R:F87	3.22	Yes	Yes	1	6	6
69	R:R:F87	R:R:L289	7.31	Yes	No	0	6	6
70	L:L:?1	R:R:F87	3.44	Yes	Yes	1	0	6
71	L:L:?1	R:R:S90	3.18	Yes	No	0	0	4
72	R:R:F91	R:R:H95	13.58	Yes	Yes	1	6	4
73	R:R:F91	R:R:M286	3.73	Yes	No	1	6	5
74	R:R:D101	R:R:N93	6.73	Yes	No	0	2	3
75	R:R:F94	R:R:H95	3.39	Yes	Yes	1	3	4
76	L:L:?1	R:R:F94	5.16	Yes	Yes	1	0	3
77	R:R:D101	R:R:G99	3.35	Yes	No	0	2	5
78	R:R:S102	R:R:V105	4.85	No	No	0	6	4
79	R:R:K103	R:R:L185	9.87	No	Yes	0	3	4
80	R:R:F106	R:R:I110	6.28	No	Yes	1	9	4
81	R:R:F106	R:R:L185	3.65	No	Yes	1	9	4
82	R:R:L107	R:R:L169	4.15	No	No	0	5	6
83	R:R:L107	R:R:L185	4.15	No	Yes	0	5	4
84	R:R:F183	R:R:I110	3.77	Yes	Yes	1	6	4
85	R:R:I110	R:R:I186	5.89	Yes	Yes	1	4	5
86	L:L:?1	R:R:I110	12.09	Yes	Yes	1	0	4
87	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
88	L:L:?1	R:R:V113	3.15	Yes	No	1	0	5
89	R:R:S165	R:R:T114	3.2	No	No	0	7	4
90	R:R:T114	R:R:W194	4.85	No	Yes	1	4	5
91	L:L:?1	R:R:T114	16.65	Yes	No	1	0	4
92	R:R:A162	R:R:M115	3.22	No	No	0	3	5
93	R:R:M115	R:R:S165	4.6	No	No	0	5	7
94	R:R:M115	R:R:Y166	8.38	No	Yes	0	5	4
95	R:R:F117	R:R:W258	7.02	Yes	Yes	1	6	8
96	R:R:C288	R:R:F117	8.38	No	Yes	1	7	6
97	L:L:?1	R:R:F117	5.16	Yes	Yes	1	0	6
98	R:R:S161	R:R:T118	3.2	No	No	0	8	6
99	R:R:T118	R:R:W194	3.64	No	Yes	1	6	5
100	R:R:I198	R:R:T118	4.56	No	No	1	7	6
101	R:R:A119	R:R:W158	7.78	No	No	0	7	9
102	R:R:A119	R:R:S161	3.42	No	No	0	7	8
103	R:R:S120	R:R:V121	3.23	No	No	0	9	8
104	R:R:F202	R:R:V121	3.93	Yes	No	1	7	8
105	R:R:V121	R:R:W258	6.13	No	Yes	1	8	8
106	R:R:G122	R:R:M157	3.49	No	No	0	5	6
107	R:R:L124	R:R:N295	4.12	No	No	2	8	9
108	R:R:L124	R:R:Y299	8.21	No	Yes	2	8	9
109	R:R:L126	R:R:T153	4.42	No	No	0	6	6
110	R:R:R131	R:R:T127	3.88	No	No	0	9	9
111	R:R:A128	R:R:T208	3.36	No	No	0	9	6
112	R:R:A128	R:R:Y209	9.34	No	Yes	0	9	9
113	R:R:I129	R:R:T208	4.56	No	No	0	6	6
114	R:R:D130	R:R:Y141	6.9	Yes	Yes	0	9	7
115	R:R:D130	R:R:L145	6.79	Yes	No	0	9	6
116	R:R:R131	R:R:Y209	7.2	No	Yes	2	9	9
117	R:R:R131	R:R:Y299	9.26	No	Yes	2	9	9
118	R:R:R136	R:R:Y132	12.35	No	Yes	0	6	8
119	R:R:H211	R:R:Y132	7.62	No	Yes	0	5	8
120	R:R:C134	R:R:Y141	8.06	No	Yes	0	8	7
121	R:R:L135	R:R:V212	4.47	No	No	0	9	9
122	R:R:R136	R:R:Y137	25.72	No	Yes	0	6	5
123	R:R:K215	R:R:R136	3.71	No	No	0	6	6
124	R:R:L144	R:R:Y137	4.69	No	Yes	0	4	5
125	R:R:P138	R:R:P139	7.79	No	No	0	8	7
126	R:R:K142	R:R:Y141	4.78	No	Yes	0	5	7
127	R:R:L154	R:R:W158	4.56	No	No	0	8	9
128	R:R:M157	R:R:S161	3.07	No	No	0	6	8
129	R:R:F197	R:R:V164	6.55	No	No	0	5	5
130	R:R:L169	R:R:Y166	7.03	No	Yes	0	6	4
131	R:R:L167	R:R:Y190	7.03	No	Yes	0	5	7
132	R:R:I186	R:R:P168	3.39	Yes	No	0	5	5
133	R:R:P187	R:R:W172	14.86	Yes	No	1	4	5
134	R:R:D189	R:R:W172	4.47	No	No	1	4	5
135	R:R:C175	R:R:T173	3.38	No	No	0	3	5
136	R:R:C174	R:R:C179	7.28	No	No	0	5	9
137	R:R:P176	R:R:R177	4.32	No	No	0	4	3
138	R:R:P178	R:R:R177	5.76	No	No	0	4	3
139	R:R:I186	R:R:S180	3.1	Yes	No	0	5	4
140	R:R:N188	R:R:S180	5.96	No	No	0	4	4
141	R:R:E181	R:R:T272	8.47	No	No	0	4	1
142	R:R:L182	R:R:S268	7.51	No	No	0	4	3
143	R:R:F281	R:R:L182	7.31	Yes	No	0	4	4
144	R:R:F183	R:R:I186	3.77	Yes	Yes	1	6	5
145	R:R:F183	R:R:L191	7.31	Yes	No	1	6	5
146	R:R:F183	R:R:M265	3.73	Yes	Yes	1	6	6
147	R:R:F183	R:R:F281	5.36	Yes	Yes	0	6	4
148	L:L:?1	R:R:F183	38.69	Yes	Yes	1	0	6
149	R:R:I186	R:R:P187	5.08	Yes	Yes	1	5	4
150	L:L:?1	R:R:I186	5.04	Yes	Yes	1	0	5
151	R:R:D189	R:R:P187	4.83	No	Yes	1	4	4
152	R:R:P187	R:R:Y190	5.56	Yes	Yes	1	4	7
153	R:R:L269	R:R:N188	10.98	No	No	0	3	4
154	R:R:W194	R:R:Y190	6.75	Yes	Yes	1	5	7
155	L:L:?1	R:R:Y190	3.31	Yes	Yes	1	0	7
156	R:R:L191	R:R:M265	5.65	No	Yes	1	5	6
157	L:L:?1	R:R:L191	3.91	Yes	No	1	0	5
158	R:R:L192	R:R:L269	5.54	No	No	0	4	3
159	R:R:I198	R:R:W194	11.74	No	Yes	1	7	5
160	R:R:M265	R:R:W194	3.49	Yes	Yes	1	6	5
161	L:L:?1	R:R:W194	15.28	Yes	Yes	1	0	5
162	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
163	R:R:F197	R:R:L201	4.87	No	No	0	5	7
164	R:R:F202	R:R:I198	5.02	Yes	No	1	7	7
165	R:R:F202	R:R:W258	6.01	Yes	Yes	1	7	8
166	R:R:F202	R:R:L262	3.65	Yes	No	0	7	6
167	R:R:L247	R:R:Y209	8.21	No	Yes	0	8	9
168	R:R:V250	R:R:Y209	5.05	No	Yes	2	8	9
169	R:R:L251	R:R:Y209	8.21	No	Yes	0	7	9
170	R:R:Y209	R:R:Y299	4.96	Yes	Yes	2	9	9
171	R:R:H211	R:R:K215	10.48	No	No	0	5	6
172	R:R:L247	R:R:V212	4.47	No	No	0	8	9
173	R:R:L213	R:R:L247	4.15	No	No	0	6	8
174	R:R:Q218	R:R:W214	12.05	No	No	0	5	3
175	R:R:K215	R:R:Q218	6.78	No	No	0	6	5
176	R:R:D240	R:R:H217	6.3	No	No	0	7	5
177	R:R:L239	R:R:V220	4.47	No	No	0	5	5
178	R:R:D240	R:R:V220	10.22	No	No	0	7	5
179	R:R:K245	R:R:V241	4.55	No	No	0	7	5
180	R:R:R302	R:R:T246	18.11	No	No	0	7	8
181	R:R:I298	R:R:L249	4.28	Yes	No	0	9	6
182	R:R:L249	R:R:R302	6.07	No	No	0	6	7
183	R:R:V250	R:R:Y299	8.83	No	Yes	2	8	9
184	R:R:V253	R:R:V294	4.81	No	No	2	7	6
185	R:R:I298	R:R:V253	4.61	Yes	No	2	9	7
186	R:R:L254	R:R:L255	4.15	No	No	0	9	6
187	R:R:L254	R:R:W258	3.42	No	Yes	0	9	8
188	R:R:C257	R:R:L287	4.76	No	No	0	8	8
189	R:R:C257	R:R:N291	7.87	No	No	0	8	9
190	R:R:C288	R:R:W258	3.92	No	Yes	1	7	8
191	R:R:N291	R:R:W258	7.91	No	Yes	0	9	8
192	R:R:F259	R:R:P260	4.33	No	No	0	5	9
193	R:R:A263	R:R:F259	6.93	No	No	0	5	5
194	R:R:L287	R:R:P260	3.28	No	No	0	8	9
195	R:R:F281	R:R:V261	3.93	Yes	No	0	4	6
196	R:R:F281	R:R:L264	6.09	Yes	No	0	4	4
197	R:R:H267	R:R:T271	4.11	No	No	0	4	3
198	R:R:L273	R:R:V277	7.45	Yes	No	0	1	3
199	R:R:K279	R:R:Q276	6.78	No	No	0	2	3
200	R:R:F283	R:R:K279	4.96	No	No	0	4	2
201	L:L:?1	R:R:S285	6.36	Yes	No	0	0	5
202	R:R:L289	R:R:M286	5.65	No	No	0	6	5
203	R:R:L289	R:R:S292	6.01	No	No	0	6	9
204	R:R:N291	R:R:N295	5.45	No	No	0	9	9
205	R:R:I298	R:R:V294	3.07	Yes	No	2	9	6
206	R:R:I306	R:R:S303	6.19	No	No	3	8	8
207	R:R:K318	R:R:L314	8.46	No	No	0	4	6
208	R:R:H316	R:R:W317	12.7	No	No	0	5	3
209	R:R:K109	R:R:V105	3.04	No	No	0	5	4
210	R:R:I156	R:R:T153	3.04	No	No	0	3	6
211	R:R:M237	R:R:V241	3.04	No	No	0	4	5
212	R:R:L108	R:R:S112	3	No	No	0	4	4
213	R:R:L144	R:R:S140	3	No	No	0	4	5
214	R:R:G304	R:R:R307	3	No	No	0	4	8
215	R:R:L42	R:R:V38	2.98	No	No	0	4	5
216	R:R:D275	R:R:S274	2.94	No	No	0	3	2
217	R:R:A282	R:R:H95	2.93	No	Yes	0	4	4
218	R:R:I27	R:R:K278	2.91	No	No	0	5	2
219	R:R:G111	R:R:Y166	2.9	No	Yes	0	6	4
220	R:R:I58	R:R:L59	2.85	No	No	0	8	4
221	R:R:I129	R:R:L125	2.85	No	Yes	0	6	6
222	R:R:I205	R:R:L125	2.85	No	Yes	0	8	6
223	R:R:I205	R:R:L254	2.85	No	No	0	8	9
224	R:R:I206	R:R:L251	2.85	No	No	0	5	7
225	R:R:P184	R:R:Y25	2.78	No	No	0	5	4
226	R:R:L42	R:R:L43	2.77	No	No	0	4	6
227	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
228	R:R:L151	R:R:L71	2.77	No	No	0	1	4
229	R:R:D101	R:R:K109	2.77	Yes	No	0	2	5
230	R:R:L125	R:R:L201	2.77	Yes	No	0	6	7
231	R:R:E50	R:R:M293	2.71	No	Yes	0	8	6
232	R:R:F81	R:R:S84	2.64	Yes	No	0	7	8
233	R:R:F81	R:R:V85	2.62	Yes	No	0	7	4
234	R:R:F97	R:R:V92	2.62	No	No	0	3	5
235	R:R:C174	R:R:W172	2.61	No	No	0	5	5
236	R:R:A79	R:R:W158	2.59	No	No	0	8	9
237	R:R:R149	R:R:T146	2.59	No	No	0	6	9
238	R:R:H219	R:R:L239	2.57	No	No	0	7	5
239	R:R:H267	R:R:L273	2.57	No	Yes	0	4	1
240	R:R:H311	R:R:L314	2.57	No	No	0	4	6
241	R:R:T208	R:R:Y132	2.5	No	Yes	0	6	8
242	R:R:F81	R:R:L82	2.44	Yes	No	0	7	7
243	R:R:I73	R:R:Y70	2.42	No	Yes	0	8	8
244	R:R:I298	R:R:Y299	2.42	Yes	Yes	2	9	9
245	R:R:L133	R:R:Y132	2.34	No	Yes	0	5	8
246	R:R:L133	R:R:Y137	2.34	No	Yes	0	5	5
247	R:R:L133	R:R:Y141	2.34	No	Yes	0	5	7
248	R:R:A77	R:R:G74	1.95	No	No	0	9	7
249	R:R:C175	R:R:P176	1.88	No	No	0	3	4
250	R:R:G30	R:R:S29	1.86	No	No	0	4	7
251	R:R:G44	R:R:S47	1.86	No	No	0	7	7
252	R:R:G304	R:R:S303	1.86	No	No	0	4	8
253	R:R:G148	R:R:T146	1.82	No	No	0	4	9
254	R:R:G171	R:R:M170	1.75	No	No	0	4	4
255	R:R:C89	R:R:V85	1.71	No	No	0	7	4
256	R:R:G204	R:R:L125	1.71	No	Yes	0	5	6
257	R:R:A37	R:R:V92	1.7	No	No	0	5	5
258	R:R:A270	R:R:T271	1.68	No	No	0	4	3
259	R:R:S308	R:R:S309	1.63	No	No	0	4	7
260	R:R:T41	R:R:V38	1.59	No	No	0	5	5
261	R:R:A48	R:R:L45	1.58	No	No	0	6	5
262	R:R:A77	R:R:L55	1.58	No	No	0	9	7
263	R:R:A310	R:R:L57	1.58	No	No	0	6	8
264	R:R:A150	R:R:L71	1.58	No	No	0	7	4
265	R:R:A216	R:R:L135	1.58	No	No	0	8	9
266	R:R:A266	R:R:L195	1.58	No	No	0	5	4
267	R:R:A244	R:R:L213	1.58	No	No	0	8	6
268	R:R:A216	R:R:L243	1.58	No	No	0	8	7
269	R:R:A216	R:R:D240	1.54	No	No	0	8	7
270	R:R:K33	R:R:V96	1.52	No	No	0	5	4
271	R:R:L273	R:R:S268	1.5	Yes	No	0	1	3
272	R:R:L39	R:R:V38	1.49	No	No	0	5	5
273	R:R:P68	R:R:R147	1.44	No	Yes	0	5	3
274	R:R:I306	R:R:L57	1.43	No	No	0	8	8
275	R:R:L167	R:R:M170	1.41	No	No	0	5	4
276	R:R:L169	R:R:M170	1.41	No	No	0	6	4
277	R:R:K278	R:R:L182	1.41	No	No	0	2	4
278	R:R:K278	R:R:L273	1.41	No	Yes	0	2	1
279	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
280	R:R:H219	R:R:S222	1.39	No	No	0	7	3
281	R:R:L45	R:R:L49	1.38	No	No	0	5	4
282	R:R:L192	R:R:L196	1.38	No	No	0	4	3
283	R:R:R147	R:R:T146	1.29	Yes	No	0	3	9
284	R:R:H219	R:R:L223	1.29	No	No	0	7	6
285	R:R:H226	R:R:L223	1.29	No	No	0	4	6
286	R:R:H62	R:R:Q63	1.24	No	No	0	5	6
287	R:R:H226	R:R:Q227	1.24	No	No	0	4	2
288	R:R:F197	R:R:L160	1.22	No	No	0	5	4
289	R:R:F200	R:R:L201	1.22	No	No	0	4	7
290	R:R:L301	R:R:R307	1.21	No	No	0	6	8
291	R:R:D24	R:R:Y25	1.15	No	No	0	4	4
292	R:R:E181	R:R:Y25	1.12	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M22	7.134	5	1	7
2	R:R:V54	3.345	4	0	9
3	R:R:L64	6.465	4	3	8
4	R:R:Y70	5.40667	6	3	8
5	R:R:L76	5.055	4	2	9
6	R:R:F81	3.668	5	0	7
7	R:R:F87	5.08	5	1	6
8	R:R:F91	7.6	4	1	6
9	R:R:F94	4.625	4	1	3
10	R:R:H95	6.926	5	1	4
11	R:R:D101	4.945	4	0	2
12	R:R:I110	7.0075	4	1	4
13	R:R:F117	5.588	5	1	6
14	R:R:L125	2.545	4	0	6
15	R:R:D130	6.6175	4	0	9
16	R:R:Y132	6.2025	4	0	8
17	R:R:Y137	8.535	4	0	5
18	R:R:Y141	5.52	4	0	7
19	R:R:R147	2.2825	4	0	3
20	R:R:Y166	5.5325	4	0	4
21	R:R:F183	10.4383	6	1	6
22	R:R:L185	5.4775	4	1	4
23	R:R:I186	4.37833	6	1	5
24	R:R:P187	7.5825	4	1	4
25	R:R:Y190	5.6625	4	1	7
26	R:R:W194	7.625	6	1	5
27	R:R:F202	4.6525	4	1	7
28	R:R:Y209	7.16167	6	2	9
29	R:R:W258	5.735	6	1	8
30	R:R:M265	4.63	4	1	6
31	R:R:L273	3.2325	4	0	1
32	R:R:F281	5.6725	4	0	4
33	R:R:M293	4.3	4	0	6
34	R:R:I298	3.595	4	2	9
35	R:R:Y299	6.395	6	2	9
36	L:L:?1	9.34	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D101	R:R:M22	11.1952	6.93	Yes	Yes	0	2	7
2	R:R:F94	R:R:M22	23.2078	3.73	Yes	Yes	1	3	7
3	R:R:F94	R:R:H95	11.5266	3.39	Yes	Yes	1	3	4
4	R:R:H95	R:R:V36	16.895	5.54	Yes	No	0	4	5
5	R:R:F283	R:R:V36	14.1058	3.93	No	No	0	4	5
6	R:R:F91	R:R:H95	12.8134	13.58	Yes	Yes	1	6	4
7	L:L:?1	R:R:F94	33.8396	5.16	Yes	Yes	1	0	3
8	L:L:?1	R:R:F117	76.019	5.16	Yes	Yes	1	0	6
9	R:R:A83	R:R:F117	38.7385	4.16	No	Yes	0	8	6
10	R:R:A83	R:R:T116	37.1755	3.36	No	No	0	8	7
11	R:R:L82	R:R:T116	35.6015	4.42	No	No	0	7	7
12	R:R:F81	R:R:L82	34.0163	2.44	Yes	No	0	7	7
13	R:R:F81	R:R:S84	22.6113	2.64	Yes	No	0	7	8
14	R:R:S47	R:R:S84	20.9378	6.52	No	No	0	7	8
15	R:R:M293	R:R:S47	17.5577	4.6	Yes	No	0	6	7
16	R:R:L43	R:R:M293	10.665	4.24	No	Yes	0	6	6
17	R:R:D80	R:R:S292	46.4376	8.83	No	No	0	9	9
18	R:R:L289	R:R:S292	47.4705	6.01	No	No	0	6	9
19	R:R:F87	R:R:L289	44.8746	7.31	Yes	No	0	6	6
20	L:L:?1	R:R:F87	29.4378	3.44	Yes	Yes	1	0	6
21	R:R:D80	R:R:N51	45.4766	13.46	No	No	0	9	9
22	R:R:N51	R:R:P296	44.7089	6.52	No	No	0	9	9
23	R:R:P296	R:R:V54	44.002	3.53	No	Yes	0	9	9
24	R:R:I58	R:R:V54	40.9864	3.07	No	Yes	0	8	9
25	R:R:I58	R:R:L64	40.7655	5.71	No	Yes	0	8	8
26	R:R:L64	R:R:Y70	26.8088	4.69	Yes	Yes	3	8	8
27	R:R:I306	R:R:Y70	11.8414	6.04	No	Yes	3	8	8
28	R:R:I306	R:R:L57	10.5766	1.43	No	No	0	8	8
29	R:R:L64	R:R:S61	10.0464	7.51	Yes	No	0	8	7
30	R:R:E305	R:R:L64	14.0506	7.95	No	Yes	3	6	8
31	R:R:K67	R:R:Y70	19.8277	7.17	No	Yes	3	6	8
32	R:R:K67	R:R:P68	31.9507	3.35	No	No	0	6	5
33	R:R:P68	R:R:R147	15.7683	1.44	No	Yes	0	5	3
34	R:R:E305	R:R:K67	13.5093	8.1	No	No	3	6	6
35	R:R:F117	R:R:W258	100	7.02	Yes	Yes	1	6	8
36	R:R:L254	R:R:W258	44.2947	3.42	No	Yes	0	9	8
37	R:R:I205	R:R:L254	42.3837	2.85	No	No	0	8	9
38	R:R:I205	R:R:L125	41.8591	2.85	No	Yes	0	8	6
39	R:R:I129	R:R:L125	38.9484	2.85	No	Yes	0	6	6
40	R:R:I129	R:R:T208	38.6336	4.56	No	No	0	6	6
41	R:R:T208	R:R:Y132	54.3301	2.5	No	Yes	0	6	8
42	R:R:L133	R:R:Y132	40.4341	2.34	No	Yes	0	5	8
43	R:R:L133	R:R:Y141	36.6564	2.34	No	Yes	0	5	7
44	R:R:D130	R:R:Y141	33.7733	6.9	Yes	Yes	0	9	7
45	R:R:D130	R:R:L145	24.9089	6.79	Yes	No	0	9	6
46	R:R:D130	R:R:F72	11.985	8.36	Yes	No	0	9	8
47	R:R:N291	R:R:W258	66.1107	7.91	No	Yes	0	9	8
48	R:R:N291	R:R:N295	63.1282	5.45	No	No	0	9	9
49	R:R:L76	R:R:N295	32.4809	5.49	Yes	No	2	9	9
50	L:L:?1	R:R:W194	12.587	15.28	Yes	Yes	1	0	5
51	R:R:L124	R:R:N295	30.5368	4.12	No	No	2	8	9
52	R:R:L76	R:R:Y299	33.3039	4.69	Yes	Yes	2	9	9
53	R:R:L124	R:R:Y299	30.0729	8.21	No	Yes	2	8	9
54	L:L:?1	R:R:T114	12.7803	16.65	Yes	No	1	0	4
55	R:R:S165	R:R:T114	12.2004	3.2	No	No	0	7	4
56	R:R:M115	R:R:S165	10.6153	4.6	No	No	0	5	7
57	R:R:A128	R:R:T208	22.0424	3.36	No	No	0	9	6
58	R:R:A128	R:R:Y209	22.65	9.34	No	Yes	0	9	9
59	R:R:Y209	R:R:Y299	48.0007	4.96	Yes	Yes	2	9	9
60	R:R:R136	R:R:Y132	12.6643	12.35	No	Yes	0	6	8
61	R:R:L247	R:R:Y209	40.1193	8.21	No	Yes	0	8	9
62	R:R:L247	R:R:V212	32.7074	4.47	No	No	0	8	9
63	L:L:?1	R:R:Y190	13.2608	3.31	Yes	Yes	1	0	7
64	L:L:?1	R:R:I186	16.4476	5.04	Yes	Yes	1	0	5
65	L:L:?1	R:R:F183	29.2721	38.69	Yes	Yes	1	0	6
66	R:R:F183	R:R:F281	28.7639	5.36	Yes	Yes	0	6	4
67	R:R:F281	R:R:L182	24.0362	7.31	Yes	No	0	4	4
68	R:R:L182	R:R:S268	10.3446	7.51	No	No	0	4	3
69	R:R:L135	R:R:V212	30.222	4.47	No	No	0	9	9
70	R:R:A216	R:R:L135	27.9189	1.58	No	No	0	8	9
71	R:R:A216	R:R:D240	22.893	1.54	No	No	0	8	7
72	R:R:D240	R:R:V220	18.0714	10.22	No	No	0	7	5
73	R:R:L239	R:R:V220	15.5252	4.47	No	No	0	5	5
74	R:R:I298	R:R:Y299	15.1221	2.42	Yes	Yes	2	9	9
75	R:R:C257	R:R:N291	10.9025	7.87	No	No	0	8	9
76	R:R:H267	R:R:L273	10.4164	2.57	No	Yes	0	4	1
77	R:R:K278	R:R:L182	12.0678	1.41	No	No	0	2	4
78	R:R:H219	R:R:L239	12.9681	2.57	No	No	0	7	5
79	R:R:F87	R:R:F91	19.176	7.5	Yes	Yes	1	6	6
80	R:R:F117	R:R:F87	30.1778	3.22	Yes	Yes	1	6	6
81	R:R:L145	R:R:P68	24.1356	3.28	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F94	R:R:M22	3.73	1	Yes	Yes	3	7	1	2
R:R:F106	R:R:M22	17.42	1	No	Yes	9	7	2	2
R:R:F94	R:R:M26	6.22	1	Yes	No	3	6	1	2
R:R:H95	R:R:M26	9.19	1	Yes	No	4	6	2	2
R:R:A83	R:R:F117	4.16	0	No	Yes	8	6	2	1
R:R:F87	R:R:F91	7.5	1	Yes	Yes	6	6	1	2
R:R:F87	R:R:V113	3.93	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	3.22	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:L289	7.31	1	Yes	No	6	6	1	2
L:L:?1	R:R:F87	3.44	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S90	3.18	1	Yes	No	0	4	0	1
R:R:F91	R:R:H95	13.58	1	Yes	Yes	6	4	2	2
R:R:F94	R:R:H95	3.39	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:F94	5.16	1	Yes	Yes	0	3	0	1
R:R:F106	R:R:I110	6.28	1	No	Yes	9	4	2	1
R:R:F183	R:R:I110	3.77	1	Yes	Yes	6	4	1	1
R:R:I110	R:R:I186	5.89	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:I110	12.09	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V113	3.15	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	3.2	0	No	No	7	4	2	1
R:R:T114	R:R:W194	4.85	1	No	Yes	4	5	1	1
L:L:?1	R:R:T114	16.65	1	Yes	No	0	4	0	1
R:R:F117	R:R:W258	7.02	1	Yes	Yes	6	8	1	2
R:R:C288	R:R:F117	8.38	1	No	Yes	7	6	2	1
L:L:?1	R:R:F117	5.16	1	Yes	Yes	0	6	0	1
R:R:T118	R:R:W194	3.64	1	No	Yes	6	5	2	1
R:R:I198	R:R:T118	4.56	1	No	No	7	6	2	2
R:R:L167	R:R:Y190	7.03	0	No	Yes	5	7	2	1
R:R:I186	R:R:P168	3.39	1	Yes	No	5	5	1	2
R:R:I186	R:R:S180	3.1	1	Yes	No	5	4	1	2
R:R:F183	R:R:I186	3.77	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:L191	7.31	1	Yes	No	6	5	1	1
R:R:F183	R:R:M265	3.73	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	5.36	1	Yes	Yes	6	4	1	2
L:L:?1	R:R:F183	38.69	1	Yes	Yes	0	6	0	1
R:R:I186	R:R:P187	5.08	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:I186	5.04	1	Yes	Yes	0	5	0	1
R:R:P187	R:R:Y190	5.56	1	Yes	Yes	4	7	2	1
R:R:W194	R:R:Y190	6.75	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:Y190	3.31	1	Yes	Yes	0	7	0	1
R:R:L191	R:R:M265	5.65	1	No	Yes	5	6	1	2
L:L:?1	R:R:L191	3.91	1	Yes	No	0	5	0	1
R:R:I198	R:R:W194	11.74	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	15.28	1	Yes	Yes	0	5	0	1
R:R:C288	R:R:W258	3.92	1	No	Yes	7	8	2	2
L:L:?1	R:R:S285	6.36	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	261
Number of Links	292
Number of Hubs	36
Number of Links mediated by Hubs	141
Number of Communities	3
Number of Nodes involved in Communities	46
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	46330
Length Of Smallest Path	3
Average Path Length	12.9587
Length of Longest Path	29
Minimum Path Strength	1.135
Average Path Strength	5.60038
Maximum Path Strength	27.67
Minimum Path Correlation	0.7
Average Path Correlation	0.923971
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	51.8342
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.039
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cannabinoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • metabolic process • regulation of metabolic process • regulation of action potential • negative regulation of action potential • negative regulation of biological process • action potential • regulation of biological quality • regulation of membrane potential • immune response • immune system process • response to amine • response to amphetamine • defense response • response to stress • inflammatory response • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • negative regulation of cellular process • mast cell activation • regulation of mast cell activation • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • cell chemotaxis • chemotaxis • response to external stimulus • leukocyte migration • taxis • cell migration • cell motility • leukocyte chemotaxis • locomotion • trans-synaptic signaling • regulation of signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • chemical synaptic transmission • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • regulation of cell communication • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • negative regulation of synaptic transmission, GABAergic • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • biological process involved in interspecies interaction between organisms • response to other organism • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dendrite • dendritic tree • endoplasmic reticulum
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KNF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KNF
Name	Olorinab
Synonyms	(2~{S},4~{S})-~{N}-[(2~{S})-3,3-dimethyl-1-oxidanyl-butan-2-yl]-9-(4-oxidanylpyrazin-2-yl)-8,9-diazatricyclo[4.3.0.0^{2,4}]nona-1(6),7-diene-7-carboxamide
Identifier
Formula	C18 H23 N5 O3
Molecular Weight	357.407
SMILES
PubChem	60164925
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	3
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUQ_nogp_Chain_R P M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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