psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F87	5.84	Yes	Yes	1	0	6
2	L:L:?1	R:R:F94	7.79	Yes	No	1	0	3
3	L:L:?1	R:R:I110	5.71	Yes	No	0	0	4
4	L:L:?1	R:R:T114	10.61	Yes	No	1	0	4
5	L:L:?1	R:R:F117	2.92	Yes	Yes	1	0	6
6	L:L:?1	R:R:F183	17.53	Yes	Yes	0	0	6
7	L:L:?1	R:R:W194	22.77	Yes	Yes	1	0	5
8	L:L:?1	R:R:M265	4.52	Yes	No	1	0	6
9	L:L:?1	R:R:F281	6.82	Yes	No	0	0	4
10	L:L:?1	R:R:S285	12.01	Yes	No	1	0	5
11	L:L:?1	R:R:C288	2.54	Yes	Yes	1	0	7
12	R:R:D24	R:R:Y25	9.2	No	No	0	4	4
13	R:R:L28	R:R:M26	2.83	Yes	Yes	1	6	6
14	R:R:F94	R:R:M26	3.73	No	Yes	1	3	6
15	R:R:H95	R:R:M26	3.94	Yes	Yes	1	4	6
16	R:R:H98	R:R:M26	2.63	No	Yes	0	4	6
17	R:R:K33	R:R:L28	2.82	No	Yes	0	5	6
18	R:R:H95	R:R:L28	3.86	Yes	Yes	1	4	6
19	R:R:K279	R:R:L28	4.23	No	Yes	0	2	6
20	R:R:G30	R:R:P31	4.06	No	No	4	4	4
21	R:R:G30	R:R:Q32	4.93	No	No	4	4	5
22	R:R:P31	R:R:Q32	4.74	No	No	4	4	5
23	R:R:K279	R:R:Q32	4.07	No	No	0	2	5
24	R:R:F283	R:R:V36	2.62	No	No	0	4	5
25	R:R:M286	R:R:V36	3.04	No	No	0	5	5
26	R:R:A37	R:R:V96	5.09	No	No	0	5	4
27	R:R:L39	R:R:L43	2.77	No	No	0	5	6
28	R:R:L39	R:R:M286	4.24	No	No	0	5	5
29	R:R:C40	R:R:F91	2.79	No	Yes	0	6	6
30	R:R:C40	R:R:M286	3.24	No	No	0	6	5
31	R:R:L43	R:R:M293	7.07	No	No	0	6	6
32	R:R:S47	R:R:S84	3.26	No	No	0	7	8
33	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
34	R:R:E50	R:R:P296	7.86	No	No	0	8	9
35	R:R:D80	R:R:N51	12.12	No	No	0	9	9
36	R:R:N51	R:R:P296	6.52	No	No	0	9	9
37	R:R:F81	R:R:V52	5.24	Yes	No	0	7	5
38	R:R:A77	R:R:V54	3.39	No	No	0	9	9
39	R:R:A300	R:R:V54	3.39	No	No	0	8	9
40	R:R:S60	R:R:Y56	12.72	No	No	0	5	5
41	R:R:L57	R:R:S309	3	No	No	0	8	7
42	R:R:A310	R:R:L57	3.15	No	No	0	6	8
43	R:R:I58	R:R:Y70	4.84	No	Yes	0	8	8
44	R:R:L59	R:R:R65	4.86	No	No	0	4	3
45	R:R:L64	R:R:S61	3	Yes	No	0	8	7
46	R:R:S309	R:R:S61	3.26	No	No	0	7	7
47	R:R:H62	R:R:Q63	6.18	No	No	0	5	6
48	R:R:Q63	R:R:R66	4.67	No	No	0	6	7
49	R:R:K67	R:R:L64	2.82	No	Yes	2	6	8
50	R:R:L64	R:R:Y70	9.38	Yes	Yes	2	8	8
51	R:R:E305	R:R:L64	2.65	Yes	Yes	2	6	8
52	R:R:I306	R:R:L64	4.28	No	Yes	2	8	8
53	R:R:K67	R:R:Y70	7.17	No	Yes	2	6	8
54	R:R:L145	R:R:P68	3.28	No	No	0	6	5
55	R:R:D130	R:R:S69	7.36	Yes	No	5	9	8
56	R:R:S69	R:R:Y141	2.54	No	Yes	5	8	7
57	R:R:S303	R:R:Y70	6.36	Yes	Yes	2	8	8
58	R:R:E305	R:R:Y70	8.98	Yes	Yes	2	6	8
59	R:R:I306	R:R:Y70	2.42	No	Yes	2	8	8
60	R:R:L71	R:R:R147	2.43	No	Yes	0	4	3
61	R:R:F72	R:R:L126	12.18	Yes	No	0	8	6
62	R:R:D130	R:R:F72	7.17	Yes	Yes	0	9	8
63	R:R:A150	R:R:F72	2.77	No	Yes	0	7	8
64	R:R:F72	R:R:L154	2.44	Yes	Yes	0	8	8
65	R:R:S123	R:R:S75	4.89	No	No	0	8	9
66	R:R:L154	R:R:S75	9.01	Yes	No	0	8	9
67	R:R:L76	R:R:S123	4.5	No	No	0	9	8
68	R:R:L124	R:R:L76	5.54	No	No	0	8	9
69	R:R:A79	R:R:W158	2.59	No	No	0	8	9
70	R:R:D80	R:R:S292	8.83	No	No	0	9	9
71	R:R:D80	R:R:N295	2.69	No	No	0	9	9
72	R:R:F81	R:R:L82	2.44	Yes	No	0	7	7
73	R:R:F81	R:R:V85	7.87	Yes	No	0	7	4
74	R:R:A83	R:R:T116	5.03	No	No	0	8	7
75	R:R:A83	R:R:F117	4.16	No	Yes	0	8	6
76	R:R:S84	R:R:V85	3.23	No	No	0	8	4
77	R:R:V113	R:R:V86	3.21	No	No	0	5	4
78	R:R:F87	R:R:S90	2.64	Yes	No	0	6	4
79	R:R:F87	R:R:F91	10.72	Yes	Yes	0	6	6
80	R:R:F87	R:R:S285	5.28	Yes	No	1	6	5
81	R:R:K109	R:R:S90	3.06	No	No	0	5	4
82	R:R:F91	R:R:H95	9.05	Yes	Yes	0	6	4
83	R:R:A282	R:R:F91	2.77	No	Yes	0	4	6
84	R:R:N93	R:R:V92	2.96	No	No	0	3	5
85	R:R:V92	R:R:V96	3.21	No	No	0	5	4
86	R:R:F97	R:R:N93	3.62	No	No	0	3	3
87	R:R:F94	R:R:H95	9.05	No	Yes	1	3	4
88	R:R:F97	R:R:V96	3.93	No	No	0	3	4
89	R:R:D101	R:R:G99	3.35	No	No	0	2	5
90	R:R:D101	R:R:K109	5.53	No	No	0	2	5
91	R:R:S102	R:R:V105	6.46	No	No	0	6	4
92	R:R:K103	R:R:L185	2.82	No	No	0	3	4
93	R:R:F106	R:R:K109	2.48	No	No	0	9	5
94	R:R:F106	R:R:I110	10.05	No	No	0	9	4
95	R:R:F106	R:R:P184	8.67	No	No	0	9	5
96	R:R:L107	R:R:P168	4.93	No	No	0	5	5
97	R:R:G111	R:R:Y166	5.79	No	Yes	0	6	4
98	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
99	R:R:S165	R:R:T114	3.2	No	No	0	7	4
100	R:R:T114	R:R:W194	3.64	No	Yes	1	4	5
101	R:R:A162	R:R:M115	3.22	No	No	0	3	5
102	R:R:M115	R:R:S165	6.13	No	No	0	5	7
103	R:R:F117	R:R:W258	5.01	Yes	Yes	1	6	8
104	R:R:C288	R:R:F117	2.79	Yes	Yes	1	7	6
105	R:R:T118	R:R:W194	2.43	No	Yes	0	6	5
106	R:R:F197	R:R:T118	2.59	No	No	0	5	6
107	R:R:A119	R:R:W158	7.78	No	No	0	7	9
108	R:R:S120	R:R:V121	3.23	No	No	0	9	8
109	R:R:L201	R:R:V121	5.96	No	No	0	7	8
110	R:R:F202	R:R:V121	3.93	No	No	0	7	8
111	R:R:G122	R:R:M157	3.49	No	No	0	5	6
112	R:R:L124	R:R:L254	2.77	No	No	0	8	9
113	R:R:L124	R:R:Y299	3.52	No	Yes	0	8	9
114	R:R:I205	R:R:L125	5.71	No	No	0	8	6
115	R:R:L126	R:R:T153	4.42	No	No	0	6	6
116	R:R:R131	R:R:T127	2.59	No	No	3	9	9
117	R:R:T127	R:R:Y299	2.5	No	Yes	3	9	9
118	R:R:A128	R:R:T208	3.36	No	No	0	9	6
119	R:R:A128	R:R:Y209	6.67	No	Yes	0	9	9
120	R:R:D130	R:R:Y141	5.75	Yes	Yes	5	9	7
121	R:R:D130	R:R:L145	4.07	Yes	No	0	9	6
122	R:R:R131	R:R:Y209	4.12	No	Yes	3	9	9
123	R:R:R131	R:R:Y299	7.2	No	Yes	3	9	9
124	R:R:R136	R:R:Y132	10.29	No	Yes	0	6	8
125	R:R:T208	R:R:Y132	2.5	No	Yes	0	6	8
126	R:R:V212	R:R:Y132	3.79	No	Yes	0	9	8
127	R:R:C134	R:R:Y141	8.06	No	Yes	0	8	7
128	R:R:R136	R:R:Y137	21.61	No	Yes	0	6	5
129	R:R:S140	R:R:Y137	2.54	No	Yes	0	5	5
130	R:R:P138	R:R:P139	7.79	No	No	0	8	7
131	R:R:L144	R:R:S140	3	No	No	0	4	5
132	R:R:R149	R:R:T146	3.88	No	No	0	6	9
133	R:R:L154	R:R:M157	2.83	Yes	No	0	8	6
134	R:R:M157	R:R:W158	3.49	No	No	0	6	9
135	R:R:F197	R:R:V164	2.62	No	No	0	5	5
136	R:R:S165	R:R:Y166	5.09	No	Yes	0	7	4
137	R:R:L169	R:R:Y166	3.52	No	Yes	0	6	4
138	R:R:L167	R:R:P168	4.93	No	No	1	5	5
139	R:R:L167	R:R:Y190	11.72	No	Yes	1	5	7
140	R:R:P168	R:R:Y190	6.95	No	Yes	1	5	7
141	R:R:C174	R:R:W172	2.61	No	No	0	5	5
142	R:R:P187	R:R:W172	9.46	No	No	0	4	5
143	R:R:C175	R:R:T173	3.38	No	No	0	3	5
144	R:R:C174	R:R:C179	7.28	No	No	6	5	9
145	R:R:C175	R:R:P176	3.77	No	No	0	3	4
146	R:R:L182	R:R:S180	3	No	No	0	4	4
147	R:R:L191	R:R:S180	3	No	No	0	5	4
148	R:R:E181	R:R:T272	2.82	No	No	0	4	1
149	R:R:L182	R:R:S268	7.51	No	No	0	4	3
150	R:R:F183	R:R:P184	4.33	Yes	No	0	6	5
151	R:R:F183	R:R:I186	5.02	Yes	No	0	6	5
152	R:R:F183	R:R:L191	2.44	Yes	No	0	6	5
153	R:R:I186	R:R:P187	5.08	No	No	0	5	4
154	R:R:D189	R:R:P187	3.22	No	No	0	4	4
155	R:R:L269	R:R:N188	4.12	No	No	0	3	4
156	R:R:S193	R:R:Y190	3.82	No	Yes	0	5	7
157	R:R:L191	R:R:L269	5.54	No	No	0	5	3
158	R:R:L192	R:R:L196	2.77	No	No	0	4	3
159	R:R:I198	R:R:W194	10.57	No	Yes	0	7	5
160	R:R:M265	R:R:W194	5.82	No	Yes	1	6	5
161	R:R:L195	R:R:L262	2.77	No	No	0	4	6
162	R:R:F197	R:R:L201	2.44	No	No	0	5	7
163	R:R:F202	R:R:I198	7.54	No	No	0	7	7
164	R:R:F200	R:R:S203	2.64	No	No	0	4	3
165	R:R:F202	R:R:W258	6.01	No	Yes	0	7	8
166	R:R:G204	R:R:S203	3.71	No	No	0	5	3
167	R:R:I205	R:R:Y209	2.42	No	Yes	0	8	9
168	R:R:I206	R:R:L251	2.85	No	No	0	5	7
169	R:R:H211	R:R:Y207	14.16	No	No	0	5	4
170	R:R:L247	R:R:Y209	5.86	No	Yes	0	8	9
171	R:R:L251	R:R:Y209	4.69	No	Yes	0	7	9
172	R:R:Y209	R:R:Y299	4.96	Yes	Yes	3	9	9
173	R:R:H211	R:R:K215	2.62	No	No	0	5	6
174	R:R:L247	R:R:V212	2.98	No	No	0	8	9
175	R:R:L213	R:R:L247	5.54	No	No	0	6	8
176	R:R:Q218	R:R:W214	9.86	No	No	0	5	3
177	R:R:D240	R:R:H217	6.3	Yes	No	0	7	5
178	R:R:H219	R:R:L239	2.57	No	No	0	7	5
179	R:R:L239	R:R:V220	2.98	No	No	0	5	5
180	R:R:D240	R:R:V220	10.22	Yes	No	0	7	5
181	R:R:D240	R:R:M237	5.54	Yes	No	0	7	4
182	R:R:R302	R:R:T246	6.47	No	No	0	7	8
183	R:R:I298	R:R:L249	2.85	Yes	No	0	9	6
184	R:R:V250	R:R:Y299	8.83	No	Yes	0	8	9
185	R:R:L254	R:R:W258	3.42	No	Yes	0	9	8
186	R:R:C288	R:R:W258	2.61	Yes	Yes	1	7	8
187	R:R:N291	R:R:W258	3.39	No	Yes	0	9	8
188	R:R:A263	R:R:F259	2.77	No	No	0	5	5
189	R:R:L287	R:R:P260	3.28	No	No	0	8	9
190	R:R:C288	R:R:V261	5.12	Yes	No	0	7	6
191	R:R:F281	R:R:L264	7.31	No	No	0	4	4
192	R:R:H267	R:R:T271	12.32	No	No	0	4	3
193	R:R:L273	R:R:V277	4.47	Yes	No	0	1	3
194	R:R:K278	R:R:L273	7.05	No	Yes	0	2	1
195	R:R:D275	R:R:Q276	2.61	No	No	0	3	3
196	R:R:D275	R:R:V277	5.84	No	No	0	3	3
197	R:R:L289	R:R:S292	3	No	No	0	6	9
198	R:R:N291	R:R:N295	10.9	No	No	0	9	9
199	R:R:I298	R:R:Y299	2.42	Yes	Yes	0	9	9
200	R:R:L301	R:R:R307	2.43	No	No	0	6	8
201	R:R:E305	R:R:S303	10.06	Yes	Yes	2	6	8
202	R:R:I306	R:R:S303	6.19	No	Yes	2	8	8
203	R:R:G304	R:R:R307	4.5	No	No	0	4	8
204	R:R:C313	R:R:W317	2.61	No	No	0	6	3
205	R:R:H316	R:R:K319	6.55	No	No	0	5	2
206	L:L:?1	R:R:V113	2.38	Yes	No	0	0	5
207	R:R:L133	R:R:Y137	2.34	No	Yes	0	5	5
208	R:R:L133	R:R:Y141	2.34	No	Yes	0	5	7
209	R:R:L195	R:R:W194	2.28	No	Yes	0	4	5
210	R:R:L262	R:R:W258	2.28	No	Yes	0	6	8
211	R:R:H62	R:R:R65	2.26	No	No	0	5	3
212	R:R:H211	R:R:Y132	2.18	No	Yes	0	5	8
213	R:R:R238	R:R:R242	2.13	No	No	0	4	8
214	R:R:A77	R:R:G74	1.95	No	No	0	9	7
215	R:R:A77	R:R:G78	1.95	No	No	0	9	7
216	R:R:W317	R:R:Y56	1.93	No	No	0	3	5
217	L:L:?1	R:R:Y190	1.87	Yes	Yes	1	0	7
218	R:R:G30	R:R:S29	1.86	No	No	0	4	7
219	R:R:G44	R:R:S47	1.86	No	No	0	7	7
220	R:R:G304	R:R:S303	1.86	No	Yes	0	4	8
221	R:R:P296	R:R:V54	1.77	No	No	0	9	9
222	R:R:G74	R:R:I58	1.76	No	No	0	7	8
223	R:R:G171	R:R:M170	1.75	No	No	0	4	4
224	R:R:G44	R:R:L43	1.71	No	No	0	7	6
225	R:R:G78	R:R:L55	1.71	No	No	0	7	7
226	R:R:A104	R:R:S102	1.71	No	No	0	1	6
227	R:R:A119	R:R:S161	1.71	No	No	0	7	8
228	R:R:G204	R:R:L125	1.71	No	No	0	5	6
229	R:R:G155	R:R:L154	1.71	No	Yes	0	4	8
230	R:R:C284	R:R:V261	1.71	No	No	0	4	6
231	R:R:A270	R:R:T271	1.68	No	No	0	4	3
232	R:R:C257	R:R:I256	1.64	No	No	0	8	5
233	R:R:A300	R:R:I73	1.62	No	No	0	8	8
234	R:R:S224	R:R:V220	1.62	No	No	0	4	5
235	R:R:V253	R:R:V294	1.6	No	No	0	7	6
236	R:R:T41	R:R:V38	1.59	No	No	0	5	5
237	R:R:C313	R:R:L57	1.59	No	No	0	6	8
238	R:R:C134	R:R:L135	1.59	No	No	0	8	9
239	R:R:T153	R:R:V152	1.59	No	No	0	6	3
240	R:R:C174	R:R:L185	1.59	No	No	6	5	4
241	R:R:C179	R:R:L185	1.59	No	No	6	9	4
242	R:R:T246	R:R:V250	1.59	No	No	0	8	8
243	R:R:A150	R:R:L71	1.58	No	No	0	7	4
244	R:R:A216	R:R:L135	1.58	No	No	0	8	9
245	R:R:A266	R:R:L195	1.58	No	No	0	5	4
246	R:R:A244	R:R:L213	1.58	No	No	0	8	6
247	R:R:A216	R:R:L243	1.58	No	No	0	8	7
248	R:R:C89	R:R:N93	1.57	No	No	0	7	3
249	R:R:C257	R:R:N291	1.57	No	No	0	8	9
250	R:R:A216	R:R:D240	1.54	No	Yes	0	8	7
251	R:R:I298	R:R:V294	1.54	Yes	No	0	9	6
252	R:R:I298	R:R:V297	1.54	Yes	No	0	9	6
253	R:R:I129	R:R:T208	1.52	No	No	0	6	6
254	R:R:L108	R:R:S112	1.5	No	No	0	4	4
255	R:R:G148	R:R:R147	1.5	No	Yes	0	4	3
256	R:R:L273	R:R:S268	1.5	Yes	No	0	1	3
257	R:R:L163	R:R:V159	1.49	No	No	0	3	3
258	R:R:L160	R:R:V164	1.49	No	No	0	4	5
259	R:R:L45	R:R:T41	1.47	No	No	0	5	5
260	R:R:I290	R:R:M293	1.46	No	No	0	4	6
261	R:R:P178	R:R:R177	1.44	No	No	0	4	3
262	R:R:F259	R:R:P260	1.44	No	No	0	5	9
263	R:R:E305	R:R:S308	1.44	Yes	No	0	6	4
264	R:R:I290	R:R:L287	1.43	No	No	0	4	8
265	R:R:P184	R:R:Y25	1.39	No	No	0	5	4
266	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
267	R:R:H312	R:R:S308	1.39	No	No	0	5	4
268	R:R:L151	R:R:L71	1.38	No	No	0	1	4
269	R:R:L192	R:R:L269	1.38	No	No	0	4	3
270	R:R:E50	R:R:L49	1.33	No	No	0	8	4
271	R:R:E181	R:R:L182	1.33	No	No	0	4	4
272	R:R:E181	R:R:L273	1.33	No	Yes	0	4	1
273	R:R:R147	R:R:T146	1.29	Yes	No	0	3	9
274	R:R:H219	R:R:L223	1.29	No	No	0	7	6
275	R:R:F259	R:R:L255	1.22	No	No	0	5	6
276	R:R:K142	R:R:Y141	1.19	No	Yes	0	5	7
277	R:R:K215	R:R:W214	1.16	No	No	0	6	3
278	R:R:R147	R:R:R65	1.07	Yes	No	0	3	3
279	R:R:R147	R:R:R66	1.07	Yes	No	0	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.94692	13	1	0
2	R:R:M26	3.2825	4	1	6
3	R:R:L28	3.435	4	1	6
4	R:R:L64	4.426	5	2	8
5	R:R:Y70	6.525	6	2	8
6	R:R:F72	6.14	4	0	8
7	R:R:F81	4.58	4	0	7
8	R:R:F87	6.12	4	1	6
9	R:R:F91	6.3325	4	0	6
10	R:R:H95	6.475	4	1	4
11	R:R:F117	3.72	4	1	6
12	R:R:D130	6.0875	4	5	9
13	R:R:Y132	4.69	4	0	8
14	R:R:Y137	6.97	4	0	5
15	R:R:Y141	3.976	5	5	7
16	R:R:R147	1.472	5	0	3
17	R:R:L154	3.9975	4	0	8
18	R:R:Y166	4.555	4	0	4
19	R:R:F183	7.33	4	0	6
20	R:R:Y190	6.09	4	1	7
21	R:R:W194	7.91833	6	1	5
22	R:R:Y209	4.78667	6	3	9
23	R:R:D240	5.9	4	0	7
24	R:R:W258	3.78667	6	1	8
25	R:R:L273	3.5875	4	0	1
26	R:R:C288	3.265	4	1	7
27	R:R:I298	2.0875	4	0	9
28	R:R:Y299	4.905	6	3	9
29	R:R:S303	6.1175	4	2	8
30	R:R:E305	5.7825	4	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F183	43.4781	17.53	Yes	Yes	0	0	6
2	L:L:?1	R:R:F94	23.9884	7.79	Yes	No	1	0	3
3	R:R:F94	R:R:M26	12.1055	3.73	No	Yes	1	3	6
4	R:R:F94	R:R:H95	10.7926	9.05	No	Yes	1	3	4
5	R:R:H95	R:R:L28	10.1472	3.86	Yes	Yes	1	4	6
6	R:R:K279	R:R:L28	14.0155	4.23	No	Yes	0	2	6
7	R:R:K279	R:R:Q32	11.2265	4.07	No	No	0	2	5
8	L:L:?1	R:R:F87	36.6984	5.84	Yes	Yes	1	0	6
9	R:R:F87	R:R:F91	31.3022	10.72	Yes	Yes	0	6	6
10	R:R:C40	R:R:F91	29.5145	2.79	No	Yes	0	6	6
11	R:R:C40	R:R:M286	28.1831	3.24	No	No	0	6	5
12	R:R:L39	R:R:M286	24.1442	4.24	No	No	0	5	5
13	R:R:L39	R:R:L43	22.7831	2.77	No	No	0	5	6
14	R:R:L43	R:R:M293	10.1992	7.07	No	No	0	6	6
15	R:R:G44	R:R:L43	11.627	1.71	No	No	0	7	6
16	R:R:G44	R:R:S47	10.1992	1.86	No	No	0	7	7
17	L:L:?1	R:R:F117	56.7481	2.92	Yes	Yes	1	0	6
18	R:R:F117	R:R:W258	57.1969	5.01	Yes	Yes	1	6	8
19	R:R:N291	R:R:W258	46.8457	3.39	No	Yes	0	9	8
20	R:R:N291	R:R:N295	43.5189	10.9	No	No	0	9	9
21	R:R:D80	R:R:N295	42.3951	2.69	No	No	0	9	9
22	R:R:D80	R:R:N51	38.9793	12.12	No	No	0	9	9
23	R:R:N51	R:R:P296	37.8259	6.52	No	No	0	9	9
24	L:L:?1	R:R:C288	56.7852	2.54	Yes	Yes	1	0	7
25	R:R:C288	R:R:W258	57.1746	2.61	Yes	Yes	1	7	8
26	R:R:P296	R:R:V54	34.3211	1.77	No	No	0	9	9
27	R:R:A77	R:R:V54	30.7495	3.39	No	No	0	9	9
28	R:R:A77	R:R:G74	27.1112	1.95	No	No	0	9	7
29	R:R:G74	R:R:I58	25.8836	1.76	No	No	0	7	8
30	R:R:I58	R:R:Y70	24.6486	4.84	No	Yes	0	8	8
31	R:R:L64	R:R:Y70	11.946	9.38	Yes	Yes	2	8	8
32	R:R:L64	R:R:S61	11.0336	3	Yes	No	0	8	7
33	R:R:L254	R:R:W258	100	3.42	No	Yes	0	9	8
34	R:R:L124	R:R:L254	99.3584	2.77	No	No	0	8	9
35	R:R:L124	R:R:L76	49.5605	5.54	No	No	0	8	9
36	R:R:L76	R:R:S123	48.5443	4.5	No	No	0	9	8
37	R:R:S123	R:R:S75	47.5615	4.89	No	No	0	8	9
38	R:R:L154	R:R:S75	46.6009	9.01	Yes	No	0	8	9
39	R:R:F72	R:R:L154	39.0943	2.44	Yes	Yes	0	8	8
40	R:R:A150	R:R:F72	15.5732	2.77	No	Yes	0	7	8
41	R:R:A150	R:R:L71	14.3159	1.58	No	No	0	7	4
42	R:R:L71	R:R:R147	11.7791	2.43	No	Yes	0	4	3
43	R:R:D130	R:R:F72	23.0279	7.17	Yes	Yes	0	9	8
44	R:R:D130	R:R:Y141	18.9704	5.75	Yes	Yes	5	9	7
45	R:R:F183	R:R:I186	11.679	5.02	Yes	No	0	6	5
46	R:R:I186	R:R:P187	10.2288	5.08	No	No	0	5	4
47	L:L:?1	R:R:T114	12.5654	10.61	Yes	No	1	0	4
48	R:R:S165	R:R:T114	11.6864	3.2	No	No	0	7	4
49	R:R:L124	R:R:Y299	55.8766	3.52	No	Yes	0	8	9
50	R:R:Y209	R:R:Y299	45.6366	4.96	Yes	Yes	3	9	9
51	R:R:A128	R:R:Y209	18.874	6.67	No	Yes	0	9	9
52	R:R:A128	R:R:T208	17.8541	3.36	No	No	0	9	6
53	R:R:T208	R:R:Y132	15.9997	2.5	No	Yes	0	6	8
54	R:R:R136	R:R:Y132	19.8235	10.29	No	Yes	0	6	8
55	R:R:L247	R:R:Y209	20.1498	5.86	No	Yes	0	8	9
56	R:R:L247	R:R:V212	17.0753	2.98	No	No	0	8	9
57	R:R:V212	R:R:Y132	16.1481	3.79	No	Yes	0	9	8
58	R:R:C134	R:R:Y141	16.3409	8.06	No	Yes	0	8	7
59	R:R:R136	R:R:Y137	17.7651	21.61	No	Yes	0	6	5
60	R:R:F183	R:R:L191	28.4983	2.44	Yes	No	0	6	5
61	R:R:L191	R:R:S180	21.7446	3	No	No	0	5	4
62	R:R:L182	R:R:S180	20.3501	3	No	No	0	4	4
63	R:R:E181	R:R:L182	10.2066	1.33	No	No	0	4	4
64	R:R:H211	R:R:Y132	12.0869	2.18	No	Yes	0	5	8
65	R:R:C134	R:R:L135	14.9835	1.59	No	No	0	8	9
66	R:R:A216	R:R:L135	13.6112	1.58	No	No	0	8	9
67	R:R:A216	R:R:D240	11.1375	1.54	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F87	5.84	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F94	7.79	1	Yes	No	0	3	0	1
L:L:?1	R:R:I110	5.71	1	Yes	No	0	4	0	1
L:L:?1	R:R:T114	10.61	1	Yes	No	0	4	0	1
L:L:?1	R:R:F117	2.92	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F183	17.53	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W194	22.77	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M265	4.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:F281	6.82	1	Yes	No	0	4	0	1
L:L:?1	R:R:S285	12.01	1	Yes	No	0	5	0	1
L:L:?1	R:R:C288	2.54	1	Yes	Yes	0	7	0	1
R:R:F94	R:R:M26	3.73	1	No	Yes	3	6	1	2
R:R:H95	R:R:M26	3.94	1	Yes	Yes	4	6	2	2
R:R:A83	R:R:F117	4.16	0	No	Yes	8	6	2	1
R:R:V113	R:R:V86	3.21	0	No	No	5	4	1	2
R:R:F87	R:R:S90	2.64	1	Yes	No	6	4	1	2
R:R:F87	R:R:F91	10.72	1	Yes	Yes	6	6	1	2
R:R:F87	R:R:S285	5.28	1	Yes	No	6	5	1	1
R:R:F91	R:R:H95	9.05	0	Yes	Yes	6	4	2	2
R:R:F94	R:R:H95	9.05	1	No	Yes	3	4	1	2
R:R:F106	R:R:I110	10.05	0	No	No	9	4	2	1
R:R:F106	R:R:P184	8.67	0	No	No	9	5	2	2
R:R:S165	R:R:T114	3.2	0	No	No	7	4	2	1
R:R:T114	R:R:W194	3.64	1	No	Yes	4	5	1	1
R:R:F117	R:R:W258	5.01	1	Yes	Yes	6	8	1	2
R:R:C288	R:R:F117	2.79	1	Yes	Yes	7	6	1	1
R:R:T118	R:R:W194	2.43	0	No	Yes	6	5	2	1
R:R:L167	R:R:P168	4.93	1	No	No	5	5	2	2
R:R:L167	R:R:Y190	11.72	1	No	Yes	5	7	2	1
R:R:P168	R:R:Y190	6.95	1	No	Yes	5	7	2	1
R:R:F183	R:R:P184	4.33	0	Yes	No	6	5	1	2
R:R:F183	R:R:I186	5.02	0	Yes	No	6	5	1	2
R:R:F183	R:R:L191	2.44	0	Yes	No	6	5	1	2
R:R:S193	R:R:Y190	3.82	0	No	Yes	5	7	2	1
R:R:I198	R:R:W194	10.57	0	No	Yes	7	5	2	1
R:R:M265	R:R:W194	5.82	1	No	Yes	6	5	1	1
R:R:C288	R:R:W258	2.61	1	Yes	Yes	7	8	1	2
R:R:C288	R:R:V261	5.12	1	Yes	No	7	6	1	2
R:R:F281	R:R:L264	7.31	0	No	No	4	4	1	2
L:L:?1	R:R:V113	2.38	1	Yes	No	0	5	0	1
R:R:L195	R:R:W194	2.28	0	No	Yes	4	5	2	1
L:L:?1	R:R:Y190	1.87	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X3L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	261
Number of Links	279
Number of Hubs	30
Number of Links mediated by Hubs	118
Number of Communities	6
Number of Nodes involved in Communities	35
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	48735
Length Of Smallest Path	3
Average Path Length	14.58
Length of Longest Path	36
Minimum Path Strength	1.18
Average Path Strength	4.8653
Maximum Path Strength	17.39
Minimum Path Correlation	0.7
Average Path Correlation	0.926452
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.9347
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.3417
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XWD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XWD
Name	4-[3-(4-fluoranyl-2~{H}-indazol-7-yl)-1,2,4-oxadiazol-5-yl]-1-(4-fluorophenyl)azepan-2-one
Synonyms
Identifier
Formula	n/a
Molecular Weight	409.389
SMILES
PubChem	172458163
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	51
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8X3L_nogp_Chain_R D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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