psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M22	R:R:M26	4.33	No	No	0	7	6
2	R:R:M22	R:R:V100	3.04	No	No	0	7	4
3	R:R:P184	R:R:Y25	6.95	No	No	0	5	4
4	R:R:F94	R:R:M26	7.46	Yes	No	0	3	6
5	R:R:H98	R:R:M26	5.25	No	No	0	4	6
6	R:R:I27	R:R:K278	13.09	No	No	0	5	2
7	R:R:I27	R:R:K279	8.72	No	No	0	5	2
8	R:R:L28	R:R:Q32	13.31	No	No	0	6	5
9	R:R:K33	R:R:L28	2.82	No	No	0	5	6
10	R:R:K279	R:R:L28	8.46	No	No	0	2	6
11	R:R:K33	R:R:S29	3.06	No	No	0	5	7
12	R:R:H98	R:R:S29	9.76	No	No	0	4	7
13	R:R:G30	R:R:P31	4.06	No	No	0	4	4
14	R:R:G30	R:R:K33	5.23	No	No	0	4	5
15	R:R:Q32	R:R:V36	2.87	No	No	0	5	5
16	R:R:F283	R:R:Q32	7.03	No	No	0	4	5
17	R:R:A37	R:R:V96	3.39	No	No	0	5	4
18	R:R:L39	R:R:M286	2.83	No	No	0	5	5
19	R:R:C40	R:R:M286	3.24	No	No	0	6	5
20	R:R:L43	R:R:M293	5.65	No	No	0	6	6
21	R:R:E50	R:R:L46	3.98	No	No	0	8	4
22	R:R:L46	R:R:M293	4.24	No	No	0	4	6
23	R:R:S47	R:R:S84	3.26	Yes	No	4	7	8
24	R:R:S292	R:R:S47	3.26	Yes	Yes	4	9	7
25	R:R:M293	R:R:S47	7.67	No	Yes	0	6	7
26	R:R:E50	R:R:P296	7.86	No	No	0	8	9
27	R:R:D80	R:R:N51	10.77	No	No	0	9	9
28	R:R:F81	R:R:N51	4.83	Yes	No	0	7	9
29	R:R:N51	R:R:P296	6.52	No	No	0	9	9
30	R:R:F81	R:R:V52	7.87	Yes	No	0	7	5
31	R:R:A77	R:R:V54	3.39	No	Yes	0	9	9
32	R:R:A300	R:R:V54	3.39	No	Yes	0	8	9
33	R:R:S60	R:R:Y56	13.99	No	No	0	5	5
34	R:R:L57	R:R:S309	3	No	No	0	8	7
35	R:R:A310	R:R:L57	3.15	No	No	0	6	8
36	R:R:C313	R:R:L57	3.17	No	No	0	6	8
37	R:R:I306	R:R:I58	2.94	No	No	0	8	8
38	R:R:L59	R:R:R65	3.64	No	No	0	4	3
39	R:R:L64	R:R:S61	9.01	No	No	0	8	7
40	R:R:L64	R:R:Y70	10.55	No	Yes	0	8	8
41	R:R:I306	R:R:L64	2.85	No	No	0	8	8
42	R:R:K67	R:R:P68	3.35	No	No	0	6	5
43	R:R:K67	R:R:Y70	8.36	No	Yes	0	6	8
44	R:R:L145	R:R:P68	3.28	Yes	No	0	6	5
45	R:R:S69	R:R:Y70	5.09	No	Yes	0	8	8
46	R:R:D130	R:R:S69	5.89	Yes	No	0	9	8
47	R:R:S303	R:R:Y70	7.63	No	Yes	0	8	8
48	R:R:E305	R:R:Y70	6.73	No	Yes	0	6	8
49	R:R:A150	R:R:L71	4.73	No	No	0	7	4
50	R:R:L151	R:R:L71	4.15	No	No	0	1	4
51	R:R:F72	R:R:L126	17.05	No	No	0	8	6
52	R:R:F72	R:R:L154	4.87	No	Yes	0	8	8
53	R:R:I73	R:R:T127	4.56	No	No	0	8	9
54	R:R:I73	R:R:Y299	3.63	No	Yes	0	8	9
55	R:R:S123	R:R:S75	4.89	No	No	0	8	9
56	R:R:L154	R:R:S75	9.01	Yes	No	5	8	9
57	R:R:S75	R:R:W158	6.18	No	Yes	5	9	9
58	R:R:L76	R:R:S120	3	Yes	No	0	9	9
59	R:R:L76	R:R:S123	6.01	Yes	No	0	9	8
60	R:R:L124	R:R:L76	5.54	No	Yes	2	8	9
61	R:R:L76	R:R:Y299	3.52	Yes	Yes	2	9	9
62	R:R:A79	R:R:W158	3.89	No	Yes	0	8	9
63	R:R:D80	R:R:S292	10.31	No	Yes	0	9	9
64	R:R:F81	R:R:V85	3.93	Yes	No	0	7	4
65	R:R:L82	R:R:T116	2.95	No	No	0	7	7
66	R:R:A83	R:R:T116	3.36	No	No	1	8	7
67	R:R:A83	R:R:F117	4.16	No	Yes	1	8	6
68	R:R:S292	R:R:S84	3.26	Yes	No	4	9	8
69	R:R:V113	R:R:V86	3.21	No	No	0	5	4
70	R:R:F87	R:R:F91	8.57	Yes	No	0	6	6
71	R:R:F87	R:R:V113	5.24	Yes	No	0	6	5
72	R:R:F117	R:R:F87	7.5	Yes	Yes	1	6	6
73	R:R:F87	R:R:S285	6.61	Yes	No	1	6	5
74	L:L:?1	R:R:F87	9.91	Yes	Yes	1	0	6
75	R:R:K109	R:R:S90	4.59	No	No	1	5	4
76	L:L:?1	R:R:S90	4.36	Yes	No	1	0	4
77	R:R:F91	R:R:H95	11.31	No	No	0	6	4
78	R:R:A282	R:R:F91	4.16	No	No	0	4	6
79	R:R:N93	R:R:V92	2.96	No	No	0	3	5
80	R:R:F97	R:R:N93	4.83	No	No	0	3	3
81	R:R:F94	R:R:H95	11.31	Yes	No	0	3	4
82	R:R:F106	R:R:F94	4.29	Yes	Yes	1	9	3
83	L:L:?1	R:R:F94	20.52	Yes	Yes	1	0	3
84	R:R:D101	R:R:V105	2.92	No	No	0	2	4
85	R:R:D101	R:R:F106	3.58	No	Yes	0	2	9
86	R:R:D101	R:R:K109	5.53	No	No	0	2	5
87	R:R:S102	R:R:V105	4.85	No	No	0	6	4
88	R:R:F106	R:R:K103	6.2	Yes	No	0	9	3
89	R:R:F106	R:R:P184	7.22	Yes	No	1	9	5
90	L:L:?1	R:R:F106	4.95	Yes	Yes	1	0	9
91	R:R:L107	R:R:L169	9.69	No	No	0	5	6
92	L:L:?1	R:R:K109	5.74	Yes	No	1	0	5
93	R:R:G111	R:R:I110	3.53	No	Yes	0	6	4
94	R:R:I110	R:R:I186	5.89	Yes	Yes	1	4	5
95	L:L:?1	R:R:I110	7.46	Yes	Yes	1	0	4
96	R:R:G111	R:R:Y166	2.9	No	Yes	0	6	4
97	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
98	R:R:S165	R:R:T114	3.2	No	No	0	7	4
99	R:R:T114	R:R:W194	4.85	No	Yes	1	4	5
100	L:L:?1	R:R:T114	10.28	Yes	No	1	0	4
101	R:R:M115	R:R:W158	3.49	No	Yes	0	5	9
102	R:R:M115	R:R:S165	6.13	No	No	0	5	7
103	R:R:M115	R:R:Y166	10.78	No	Yes	0	5	4
104	R:R:F117	R:R:T116	3.89	Yes	No	1	6	7
105	R:R:F117	R:R:W258	10.02	Yes	Yes	1	6	8
106	L:L:?1	R:R:F117	9.91	Yes	Yes	1	0	6
107	R:R:S161	R:R:T118	3.2	No	No	0	8	6
108	R:R:T118	R:R:W194	6.06	No	Yes	1	6	5
109	R:R:I198	R:R:T118	3.04	Yes	No	1	7	6
110	R:R:A119	R:R:W158	6.48	No	Yes	0	7	9
111	R:R:A119	R:R:S161	3.42	No	No	0	7	8
112	R:R:I198	R:R:V121	3.07	Yes	No	1	7	8
113	R:R:L201	R:R:V121	4.47	No	No	0	7	8
114	R:R:F202	R:R:V121	6.55	Yes	No	1	7	8
115	R:R:M157	R:R:S123	3.07	Yes	No	0	6	8
116	R:R:L124	R:R:Y299	5.86	No	Yes	2	8	9
117	R:R:I129	R:R:L125	5.71	No	No	0	6	6
118	R:R:L125	R:R:L201	4.15	No	No	0	6	7
119	R:R:I205	R:R:L125	7.14	No	No	0	8	6
120	R:R:L126	R:R:T153	2.95	No	No	0	6	6
121	R:R:L126	R:R:M157	5.65	No	Yes	0	6	6
122	R:R:A128	R:R:T208	3.36	No	No	0	9	6
123	R:R:A128	R:R:Y209	6.67	No	Yes	0	9	9
124	R:R:I129	R:R:L133	2.85	No	No	0	6	5
125	R:R:C134	R:R:D130	4.67	No	Yes	3	8	9
126	R:R:D130	R:R:Y141	11.49	Yes	No	3	9	7
127	R:R:D130	R:R:L145	4.07	Yes	Yes	3	9	6
128	R:R:R131	R:R:Y209	5.14	No	Yes	0	9	9
129	R:R:R131	R:R:Y299	6.17	No	Yes	0	9	9
130	R:R:R136	R:R:Y132	11.32	No	Yes	0	6	8
131	R:R:T208	R:R:Y132	4.99	No	Yes	0	6	8
132	R:R:H211	R:R:Y132	5.44	No	Yes	0	5	8
133	R:R:V212	R:R:Y132	3.79	No	Yes	0	9	8
134	R:R:C134	R:R:Y141	9.41	No	No	3	8	7
135	R:R:L135	R:R:V212	4.47	No	No	0	9	9
136	R:R:R136	R:R:Y137	15.43	No	No	0	6	5
137	R:R:K215	R:R:R136	3.71	No	No	0	6	6
138	R:R:P138	R:R:P139	7.79	No	No	0	8	7
139	R:R:R149	R:R:T146	3.88	No	No	0	6	9
140	R:R:G148	R:R:R147	4.5	No	No	0	4	3
141	R:R:L151	R:R:R147	4.86	No	No	0	1	3
142	R:R:L154	R:R:M157	2.83	Yes	Yes	5	8	6
143	R:R:L154	R:R:W158	5.69	Yes	Yes	5	8	9
144	R:R:M157	R:R:W158	10.47	Yes	Yes	5	6	9
145	R:R:F197	R:R:V164	7.87	Yes	No	0	5	5
146	R:R:L167	R:R:W172	7.97	No	No	0	5	5
147	R:R:P168	R:R:Y190	23.64	No	Yes	0	5	7
148	R:R:L169	R:R:M170	8.48	No	No	0	6	4
149	R:R:W172	R:R:Y190	7.72	No	Yes	0	5	7
150	R:R:C175	R:R:T173	3.38	No	No	0	3	5
151	R:R:C174	R:R:C179	7.28	No	No	0	5	9
152	R:R:C174	R:R:P187	5.65	No	No	0	5	4
153	R:R:C175	R:R:P176	7.53	No	No	0	3	4
154	R:R:P176	R:R:R177	2.88	No	No	0	4	3
155	R:R:P178	R:R:R177	5.76	No	No	0	4	3
156	R:R:C179	R:R:L185	3.17	No	No	0	9	4
157	R:R:I186	R:R:S180	4.64	Yes	No	0	5	4
158	R:R:L191	R:R:S180	4.5	No	No	0	5	4
159	R:R:E181	R:R:L273	18.55	No	No	0	4	1
160	R:R:F183	R:R:L182	8.53	Yes	No	1	6	4
161	R:R:L182	R:R:S268	7.51	No	No	0	4	3
162	R:R:F281	R:R:L182	10.96	Yes	No	1	4	4
163	R:R:F183	R:R:I186	6.28	Yes	Yes	1	6	5
164	R:R:F183	R:R:F281	6.43	Yes	Yes	1	6	4
165	L:L:?1	R:R:F183	20.52	Yes	Yes	1	0	6
166	L:L:?1	R:R:P184	3.82	Yes	No	1	0	5
167	R:R:I186	R:R:P187	3.39	Yes	No	0	5	4
168	L:L:?1	R:R:I186	3.32	Yes	Yes	1	0	5
169	R:R:P187	R:R:Y190	4.17	No	Yes	0	4	7
170	R:R:L269	R:R:N188	4.12	No	No	0	3	4
171	R:R:W194	R:R:Y190	8.68	Yes	Yes	1	5	7
172	L:L:?1	R:R:Y190	3.41	Yes	Yes	1	0	7
173	R:R:L191	R:R:M265	2.83	No	Yes	0	5	6
174	R:R:L191	R:R:L269	5.54	No	No	0	5	3
175	R:R:L192	R:R:L269	6.92	No	No	0	4	3
176	R:R:I198	R:R:W194	14.09	Yes	Yes	1	7	5
177	R:R:M265	R:R:W194	4.65	Yes	Yes	1	6	5
178	L:L:?1	R:R:W194	17.87	Yes	Yes	1	0	5
179	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
180	R:R:F197	R:R:F200	3.22	Yes	No	0	5	4
181	R:R:F197	R:R:L201	3.65	Yes	No	0	5	7
182	R:R:F202	R:R:I198	5.02	Yes	Yes	1	7	7
183	R:R:I198	R:R:L262	5.71	Yes	No	1	7	6
184	R:R:F202	R:R:L254	3.65	Yes	No	1	7	9
185	R:R:F202	R:R:W258	6.01	Yes	Yes	1	7	8
186	R:R:F202	R:R:L262	3.65	Yes	No	1	7	6
187	R:R:I205	R:R:L254	2.85	No	No	0	8	9
188	R:R:H211	R:R:Y207	13.07	No	No	0	5	4
189	R:R:L247	R:R:Y209	8.21	Yes	Yes	2	8	9
190	R:R:V250	R:R:Y209	5.05	Yes	Yes	2	8	9
191	R:R:L251	R:R:Y209	9.38	No	Yes	0	7	9
192	R:R:L247	R:R:V212	2.98	Yes	No	0	8	9
193	R:R:A244	R:R:L213	3.15	No	No	0	8	6
194	R:R:K215	R:R:W214	3.48	No	No	7	6	3
195	R:R:Q218	R:R:W214	5.48	No	No	7	5	3
196	R:R:K215	R:R:Q218	8.14	No	No	7	6	5
197	R:R:D240	R:R:H217	7.56	Yes	No	0	7	5
198	R:R:L239	R:R:V220	4.47	Yes	No	0	5	5
199	R:R:D240	R:R:V220	5.84	Yes	No	0	7	5
200	R:R:H226	R:R:Q227	11.13	No	No	0	4	2
201	R:R:D240	R:R:V241	2.92	Yes	No	0	7	5
202	R:R:K245	R:R:V241	4.55	No	No	0	7	5
203	R:R:R302	R:R:T246	10.35	No	No	0	7	8
204	R:R:L247	R:R:V250	2.98	Yes	Yes	2	8	8
205	R:R:L249	R:R:R302	4.86	No	No	0	6	7
206	R:R:I298	R:R:V250	3.07	Yes	Yes	2	9	8
207	R:R:V250	R:R:Y299	6.31	Yes	Yes	2	8	9
208	R:R:V253	R:R:V294	4.81	No	Yes	2	7	6
209	R:R:I298	R:R:V253	4.61	Yes	No	2	9	7
210	R:R:L254	R:R:W258	4.56	No	Yes	1	9	8
211	R:R:C257	R:R:N291	7.87	No	Yes	0	8	9
212	R:R:C288	R:R:W258	9.14	No	Yes	0	7	8
213	R:R:N291	R:R:W258	6.78	Yes	Yes	0	9	8
214	L:L:?1	R:R:W258	5.29	Yes	Yes	1	0	8
215	R:R:F259	R:R:P260	4.33	No	No	0	5	9
216	R:R:A263	R:R:F259	4.16	No	No	0	5	5
217	L:L:?1	R:R:M265	4.11	Yes	Yes	1	0	6
218	R:R:H267	R:R:T271	6.85	No	No	0	4	3
219	R:R:K278	R:R:L273	5.64	No	No	0	2	1
220	R:R:K279	R:R:Q276	17.63	No	No	0	2	3
221	R:R:F281	R:R:S285	3.96	Yes	No	1	4	5
222	L:L:?1	R:R:F281	10.62	Yes	Yes	1	0	4
223	L:L:?1	R:R:S285	6.11	Yes	No	1	0	5
224	R:R:L289	R:R:S292	3	No	Yes	0	6	9
225	R:R:N291	R:R:V294	4.43	Yes	Yes	0	9	6
226	R:R:N291	R:R:N295	10.9	Yes	No	0	9	9
227	R:R:I298	R:R:V294	4.61	Yes	Yes	2	9	6
228	R:R:I298	R:R:Y299	6.04	Yes	Yes	2	9	9
229	R:R:I306	R:R:S303	6.19	No	No	0	8	8
230	R:R:G304	R:R:R307	7.51	No	No	0	4	8
231	R:R:K318	R:R:L314	4.23	No	No	0	4	6
232	R:R:H316	R:R:K319	9.17	No	No	0	5	2
233	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
234	R:R:L154	R:R:L71	2.77	Yes	No	0	8	4
235	R:R:L133	R:R:L145	2.77	No	Yes	3	5	6
236	R:R:L135	R:R:L243	2.77	No	No	6	9	7
237	R:R:L213	R:R:L247	2.77	No	Yes	0	6	8
238	R:R:D240	R:R:M237	2.77	Yes	No	0	7	4
239	R:R:L239	R:R:L243	2.77	Yes	No	6	5	7
240	R:R:D80	R:R:N295	2.69	No	No	0	9	9
241	R:R:A162	R:R:Y166	2.67	No	Yes	0	3	4
242	R:R:R238	R:R:V241	2.62	No	No	0	4	5
243	R:R:H219	R:R:L223	2.57	No	No	0	7	6
244	R:R:H219	R:R:L239	2.57	No	Yes	0	7	5
245	R:R:H267	R:R:L264	2.57	No	No	0	4	4
246	R:R:V261	R:R:W258	2.45	No	Yes	0	6	8
247	R:R:F197	R:R:L160	2.44	Yes	No	0	5	4
248	R:R:Q63	R:R:R66	2.34	No	No	0	6	7
249	R:R:A88	R:R:G44	1.95	No	No	0	6	7
250	R:R:A77	R:R:G74	1.95	No	No	0	9	7
251	R:R:A77	R:R:G78	1.95	No	No	0	9	7
252	R:R:G44	R:R:S47	1.86	No	Yes	4	7	7
253	R:R:G44	R:R:S84	1.86	No	No	4	7	8
254	R:R:P296	R:R:V54	1.77	No	Yes	0	9	9
255	R:R:G122	R:R:M157	1.75	No	Yes	0	5	6
256	R:R:C40	R:R:V36	1.71	No	No	0	6	5
257	R:R:G78	R:R:L55	1.71	No	No	0	7	7
258	R:R:A104	R:R:S102	1.71	No	No	0	1	6
259	R:R:G155	R:R:L154	1.71	No	Yes	0	4	8
260	R:R:G171	R:R:L167	1.71	No	No	0	4	5
261	R:R:A35	R:R:T34	1.68	No	No	0	5	4
262	R:R:S309	R:R:S61	1.63	No	No	0	7	7
263	R:R:V92	R:R:V96	1.6	No	No	0	5	4
264	R:R:S274	R:R:T272	1.6	No	No	0	2	1
265	R:R:V294	R:R:V297	1.6	Yes	No	0	6	6
266	R:R:T41	R:R:V92	1.59	No	No	0	5	5
267	R:R:T246	R:R:V250	1.59	No	Yes	0	8	8
268	R:R:C284	R:R:L264	1.59	No	No	0	4	4
269	R:R:C284	R:R:L287	1.59	No	No	0	4	8
270	R:R:A35	R:R:L39	1.58	No	No	0	5	5
271	R:R:A216	R:R:L135	1.58	No	No	6	8	9
272	R:R:A266	R:R:L195	1.58	No	No	0	5	4
273	R:R:A216	R:R:L239	1.58	No	Yes	6	8	5
274	R:R:A216	R:R:L243	1.58	No	No	6	8	7
275	R:R:C89	R:R:N93	1.57	No	No	0	7	3
276	R:R:T271	R:R:T272	1.57	No	No	0	3	1
277	R:R:I156	R:R:V152	1.54	No	No	0	3	3
278	R:R:A280	R:R:Q276	1.52	No	No	0	3	3
279	R:R:L223	R:R:S222	1.5	No	No	0	6	3
280	R:R:L301	R:R:V54	1.49	No	Yes	0	6	9
281	R:R:L273	R:R:V277	1.49	No	No	0	1	3
282	R:R:L301	R:R:V297	1.49	No	No	0	6	6
283	R:R:C313	R:R:H312	1.47	No	No	0	6	5
284	R:R:G204	R:R:Y207	1.45	No	No	0	5	4
285	R:R:Q63	R:R:S61	1.44	No	No	0	6	7
286	R:R:I290	R:R:L43	1.43	No	No	0	4	6
287	R:R:I58	R:R:L59	1.43	No	No	0	8	4
288	R:R:I110	R:R:L107	1.43	Yes	No	0	4	5
289	R:R:I206	R:R:L251	1.43	No	No	0	5	7
290	R:R:I256	R:R:L255	1.43	No	No	0	5	6
291	R:R:I290	R:R:L287	1.43	No	No	0	4	8
292	R:R:P138	R:R:Y137	1.39	No	No	0	8	5
293	R:R:L46	R:R:L49	1.38	No	No	0	4	4
294	R:R:L133	R:R:L144	1.38	No	No	3	5	4
295	R:R:L144	R:R:L145	1.38	No	Yes	3	4	6
296	R:R:L223	R:R:Q227	1.33	No	No	0	6	2
297	R:R:S140	R:R:Y137	1.27	No	No	0	5	5
298	R:R:K142	R:R:Y141	1.19	No	No	0	5	7
299	R:R:D189	R:R:R177	1.19	No	No	0	4	3
300	R:R:H62	R:R:R66	1.13	No	No	0	5	7
301	R:R:H316	R:R:W317	1.06	No	No	0	5	3
302	R:R:W317	R:R:Y56	0.96	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S47	4.0125	4	4	7
2	R:R:V54	2.51	4	0	9
3	R:R:Y70	7.672	5	0	8
4	R:R:L76	4.5175	4	2	9
5	R:R:F81	4.85	4	0	7
6	R:R:F87	7.566	5	1	6
7	R:R:F94	10.895	4	1	3
8	R:R:F106	5.248	5	1	9
9	R:R:I110	4.5775	4	1	4
10	R:R:F117	7.096	5	1	6
11	R:R:D130	6.53	4	3	9
12	R:R:Y132	6.385	4	0	8
13	R:R:L145	2.875	4	3	6
14	R:R:L154	4.48	6	5	8
15	R:R:M157	4.754	5	5	6
16	R:R:W158	6.03333	6	5	9
17	R:R:Y166	5.0425	4	0	4
18	R:R:F183	10.44	4	1	6
19	R:R:I186	4.704	5	1	5
20	R:R:Y190	9.524	5	1	7
21	R:R:W194	9.36667	6	1	5
22	R:R:F197	4.295	4	0	5
23	R:R:I198	6.186	5	1	7
24	R:R:F202	4.976	5	1	7
25	R:R:Y209	6.89	5	2	9
26	R:R:L239	2.8475	4	6	5
27	R:R:D240	4.7725	4	0	7
28	R:R:L247	4.235	4	2	8
29	R:R:V250	3.8	5	2	8
30	R:R:W258	6.32143	7	1	8
31	R:R:M265	4.31	4	1	6
32	R:R:F281	7.9925	4	1	4
33	R:R:N291	7.495	4	0	9
34	R:R:S292	4.9575	4	4	9
35	R:R:V294	3.8625	4	2	6
36	R:R:I298	4.5825	4	2	9
37	R:R:Y299	5.255	6	2	9
38	L:L:?1	8.71765	17	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M26	37.4979	7.46	Yes	No	0	3	6
2	L:L:?1	R:R:F94	38.437	20.52	Yes	Yes	1	0	3
3	R:R:H98	R:R:M26	33.3485	5.25	No	No	0	4	6
4	R:R:K279	R:R:L28	12.8351	8.46	No	No	0	2	6
5	R:R:K33	R:R:L28	26.2052	2.82	No	No	0	5	6
6	R:R:K33	R:R:S29	30.5254	3.06	No	No	0	5	7
7	R:R:H98	R:R:S29	31.9426	9.76	No	No	0	4	7
8	R:R:L28	R:R:Q32	12.6302	13.31	No	No	0	6	5
9	R:R:L43	R:R:M293	15.4135	5.65	No	No	0	6	6
10	R:R:M293	R:R:S47	18.3562	7.67	No	Yes	0	6	7
11	R:R:S292	R:R:S47	22.8414	3.26	Yes	Yes	4	9	7
12	R:R:D80	R:R:S292	30.81	10.31	No	Yes	0	9	9
13	R:R:D80	R:R:N295	43.11	2.69	No	No	0	9	9
14	R:R:N291	R:R:N295	44.4533	10.9	Yes	No	0	9	9
15	R:R:N291	R:R:W258	100	6.78	Yes	Yes	0	9	8
16	L:L:?1	R:R:W258	84.2507	5.29	Yes	Yes	1	0	8
17	R:R:D80	R:R:N51	12.727	10.77	No	No	0	9	9
18	R:R:L301	R:R:V54	11.5032	1.49	No	Yes	0	6	9
19	R:R:L301	R:R:V297	12.818	1.49	No	No	0	6	6
20	R:R:V294	R:R:V297	14.241	1.6	Yes	No	0	6	6
21	R:R:N291	R:R:V294	79.7996	4.43	Yes	Yes	0	9	6
22	R:R:L57	R:R:S309	12.1293	3	No	No	0	8	7
23	R:R:S309	R:R:S61	14.8785	1.63	No	No	0	7	7
24	R:R:L64	R:R:S61	27.1558	9.01	No	No	0	8	7
25	R:R:L64	R:R:Y70	41.7952	10.55	No	Yes	0	8	8
26	R:R:K67	R:R:Y70	30.9693	8.36	No	Yes	0	6	8
27	R:R:K67	R:R:P68	32.3524	3.35	No	No	0	6	5
28	R:R:L145	R:R:P68	33.5762	3.28	Yes	No	0	6	5
29	R:R:L133	R:R:L145	72.5653	2.77	No	Yes	3	5	6
30	R:R:I129	R:R:L133	75.2519	2.85	No	No	0	6	5
31	R:R:I129	R:R:L125	76.4358	5.71	No	No	0	6	6
32	R:R:I205	R:R:L125	62.5875	7.14	No	No	0	8	6
33	R:R:I205	R:R:L254	63.6405	2.85	No	No	0	8	9
34	R:R:L254	R:R:W258	63.8113	4.56	No	Yes	1	9	8
35	R:R:S69	R:R:Y70	31.3279	5.09	No	Yes	0	8	8
36	R:R:D130	R:R:S69	32.5517	5.89	Yes	No	0	9	8
37	R:R:D130	R:R:L145	38.1126	4.07	Yes	Yes	3	9	6
38	R:R:I306	R:R:L64	12.1464	2.85	No	No	0	8	8
39	R:R:I306	R:R:S303	12.2944	6.19	No	No	0	8	8
40	R:R:S303	R:R:Y70	14.9695	7.63	No	Yes	0	8	8
41	R:R:I306	R:R:I58	18.527	2.94	No	No	0	8	8
42	R:R:I58	R:R:L59	12.3684	1.43	No	No	0	8	4
43	R:R:L154	R:R:L71	12.9546	2.77	Yes	No	0	8	4
44	R:R:L154	R:R:W158	10.4559	5.69	Yes	Yes	5	8	9
45	R:R:M115	R:R:W158	17.0926	3.49	No	Yes	0	5	9
46	R:R:M115	R:R:S165	14.0361	6.13	No	No	0	5	7
47	R:R:S165	R:R:T114	14.998	3.2	No	No	0	7	4
48	L:L:?1	R:R:T114	13.3075	10.28	Yes	No	1	0	4
49	R:R:I298	R:R:Y299	14.3434	6.04	Yes	Yes	2	9	9
50	R:R:I298	R:R:V294	76.3049	4.61	Yes	Yes	2	9	6
51	R:R:S123	R:R:S75	10.5584	4.89	No	No	0	8	9
52	R:R:M157	R:R:S123	13.04	3.07	Yes	No	0	6	8
53	R:R:L76	R:R:Y299	24.179	3.52	Yes	Yes	2	9	9
54	L:L:?1	R:R:I110	10.2738	7.46	Yes	Yes	1	0	4
55	R:R:S161	R:R:T118	10.8828	3.2	No	No	0	8	6
56	R:R:I198	R:R:W194	10.2282	14.09	Yes	Yes	1	7	5
57	R:R:A119	R:R:S161	10.3876	3.42	No	No	0	7	8
58	R:R:I198	R:R:V121	16.5803	3.07	Yes	No	1	7	8
59	R:R:F202	R:R:W258	10.012	6.01	Yes	Yes	1	7	8
60	R:R:L201	R:R:V121	21.9591	4.47	No	No	0	7	8
61	R:R:I298	R:R:V250	61.8647	3.07	Yes	Yes	2	9	8
62	R:R:L247	R:R:V250	64.4715	2.98	Yes	Yes	2	8	8
63	R:R:L247	R:R:V212	62.1322	2.98	Yes	No	0	8	9
64	R:R:V212	R:R:Y132	20.3654	3.79	No	Yes	0	9	8
65	R:R:R136	R:R:Y132	13.7913	11.32	No	Yes	0	6	8
66	R:R:L135	R:R:V212	45.3014	4.47	No	No	0	9	9
67	L:L:?1	R:R:Y190	12.6416	3.41	Yes	Yes	1	0	7
68	R:R:C174	R:R:P187	10.769	5.65	No	No	0	5	4
69	R:R:D240	R:R:V220	19.4206	5.84	Yes	No	0	7	5
70	R:R:L239	R:R:V220	22.4031	4.47	Yes	No	0	5	5
71	R:R:L239	R:R:L243	20.3768	2.77	Yes	No	6	5	7
72	R:R:L135	R:R:L243	21.8851	2.77	No	No	6	9	7
73	R:R:A216	R:R:L239	20.5703	1.58	No	Yes	6	8	5
74	R:R:A216	R:R:L135	22.0957	1.58	No	No	6	8	9
75	R:R:H219	R:R:L223	12.9945	2.57	No	No	0	7	6
76	R:R:H219	R:R:L239	15.9998	2.57	No	Yes	0	7	5
77	R:R:C284	R:R:L287	10.3762	1.59	No	No	0	4	8
78	R:R:I290	R:R:L287	12.0667	1.43	No	No	0	4	8
79	R:R:I290	R:R:L43	13.7458	1.43	No	No	0	4	6
80	R:R:L76	R:R:S123	22.147	6.01	Yes	No	0	9	8
81	R:R:A119	R:R:W158	10.0575	6.48	No	Yes	0	7	9
82	R:R:L125	R:R:L201	15.1403	4.15	No	No	0	6	7
83	R:R:V250	R:R:Y299	14.4117	6.31	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P184	R:R:Y25	6.95	1	No	No	5	4	1	2
R:R:F94	R:R:M26	7.46	1	Yes	No	3	6	1	2
R:R:A83	R:R:T116	3.36	1	No	No	8	7	2	2
R:R:A83	R:R:F117	4.16	1	No	Yes	8	6	2	1
R:R:F87	R:R:F91	8.57	1	Yes	No	6	6	1	2
R:R:F87	R:R:V113	5.24	1	Yes	No	6	5	1	2
R:R:F117	R:R:F87	7.5	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:S285	6.61	1	Yes	No	6	5	1	1
L:L:?1	R:R:F87	9.91	1	Yes	Yes	0	6	0	1
R:R:K109	R:R:S90	4.59	1	No	No	5	4	1	1
L:L:?1	R:R:S90	4.36	1	Yes	No	0	4	0	1
R:R:F91	R:R:H95	11.31	0	No	No	6	4	2	2
R:R:F94	R:R:H95	11.31	1	Yes	No	3	4	1	2
R:R:F106	R:R:F94	4.29	1	Yes	Yes	9	3	1	1
L:L:?1	R:R:F94	20.52	1	Yes	Yes	0	3	0	1
R:R:D101	R:R:F106	3.58	0	No	Yes	2	9	2	1
R:R:D101	R:R:K109	5.53	0	No	No	2	5	2	1
R:R:F106	R:R:K103	6.2	1	Yes	No	9	3	1	2
R:R:F106	R:R:P184	7.22	1	Yes	No	9	5	1	1
L:L:?1	R:R:F106	4.95	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:K109	5.74	1	Yes	No	0	5	0	1
R:R:G111	R:R:I110	3.53	0	No	Yes	6	4	2	1
R:R:I110	R:R:I186	5.89	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:I110	7.46	1	Yes	Yes	0	4	0	1
R:R:S165	R:R:T114	3.2	0	No	No	7	4	2	1
R:R:T114	R:R:W194	4.85	1	No	Yes	4	5	1	1
L:L:?1	R:R:T114	10.28	1	Yes	No	0	4	0	1
R:R:F117	R:R:T116	3.89	1	Yes	No	6	7	1	2
R:R:F117	R:R:W258	10.02	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:F117	9.91	1	Yes	Yes	0	6	0	1
R:R:T118	R:R:W194	6.06	1	No	Yes	6	5	2	1
R:R:I198	R:R:T118	3.04	1	Yes	No	7	6	2	2
R:R:P168	R:R:Y190	23.64	0	No	Yes	5	7	2	1
R:R:W172	R:R:Y190	7.72	0	No	Yes	5	7	2	1
R:R:I186	R:R:S180	4.64	1	Yes	No	5	4	1	2
R:R:L191	R:R:S180	4.5	0	No	No	5	4	2	2
R:R:F183	R:R:L182	8.53	1	Yes	No	6	4	1	2
R:R:F281	R:R:L182	10.96	1	Yes	No	4	4	1	2
R:R:F183	R:R:I186	6.28	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:F281	6.43	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F183	20.52	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	3.82	1	Yes	No	0	5	0	1
R:R:I186	R:R:P187	3.39	1	Yes	No	5	4	1	2
L:L:?1	R:R:I186	3.32	1	Yes	Yes	0	5	0	1
R:R:P187	R:R:Y190	4.17	0	No	Yes	4	7	2	1
R:R:W194	R:R:Y190	8.68	1	Yes	Yes	5	7	1	1
L:L:?1	R:R:Y190	3.41	1	Yes	Yes	0	7	0	1
R:R:L191	R:R:M265	2.83	0	No	Yes	5	6	2	1
R:R:I198	R:R:W194	14.09	1	Yes	Yes	7	5	2	1
R:R:M265	R:R:W194	4.65	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:W194	17.87	1	Yes	Yes	0	5	0	1
R:R:L195	R:R:M265	5.65	0	No	Yes	4	6	2	1
R:R:F202	R:R:I198	5.02	1	Yes	Yes	7	7	2	2
R:R:F202	R:R:L254	3.65	1	Yes	No	7	9	2	2
R:R:F202	R:R:W258	6.01	1	Yes	Yes	7	8	2	1
R:R:L254	R:R:W258	4.56	1	No	Yes	9	8	2	1
R:R:C288	R:R:W258	9.14	0	No	Yes	7	8	2	1
R:R:N291	R:R:W258	6.78	0	Yes	Yes	9	8	2	1
L:L:?1	R:R:W258	5.29	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M265	4.11	1	Yes	Yes	0	6	0	1
R:R:F281	R:R:S285	3.96	1	Yes	No	4	5	1	1
L:L:?1	R:R:F281	10.62	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S285	6.11	1	Yes	No	0	5	0	1
R:R:V261	R:R:W258	2.45	0	No	Yes	6	8	2	1
R:R:I110	R:R:L107	1.43	1	Yes	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	263
Number of Links	302
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	7
Number of Nodes involved in Communities	57
Number of Links involved in Communities	83

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	43630
Length Of Smallest Path	3
Average Path Length	13.2897
Length of Longest Path	31
Minimum Path Strength	1.01
Average Path Strength	5.36695
Maximum Path Strength	17.4933
Minimum Path Correlation	0.7
Average Path Correlation	0.927191
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.6825
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3134
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KO8
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KO8
Name	1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
Synonyms
Identifier
Formula	C25 H31 F N4 O3
Molecular Weight	454.537
SMILES
PubChem	46219896
Formal Charge	0
Total Atoms	64
Total Chiral Atoms	0
Total Bonds	67
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUT_nogp_Chain_R P M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8GUT_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.