psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P184	R:R:Y25	18.08	No	No	0	5	4
2	R:R:F94	R:R:M26	6.22	Yes	Yes	0	3	6
3	R:R:H98	R:R:M26	5.25	No	Yes	0	4	6
4	R:R:I27	R:R:K278	8.72	No	No	0	5	2
5	R:R:I27	R:R:K279	5.82	No	No	0	5	2
6	R:R:L28	R:R:Q32	3.99	Yes	No	4	6	5
7	R:R:H95	R:R:L28	9	Yes	Yes	0	4	6
8	R:R:K279	R:R:L28	5.64	No	Yes	0	2	6
9	R:R:F283	R:R:L28	10.96	No	Yes	4	4	6
10	R:R:K33	R:R:S29	9.18	No	No	3	5	7
11	R:R:H98	R:R:S29	4.18	No	No	3	4	7
12	R:R:G30	R:R:P31	4.06	No	No	0	4	4
13	R:R:F283	R:R:Q32	11.71	No	No	4	4	5
14	R:R:H95	R:R:K33	3.93	Yes	No	0	4	5
15	R:R:H98	R:R:K33	10.48	No	No	3	4	5
16	R:R:A37	R:R:V96	5.09	No	No	0	5	4
17	R:R:L39	R:R:L43	4.15	No	Yes	0	5	6
18	R:R:L39	R:R:M286	4.24	No	Yes	0	5	5
19	R:R:C40	R:R:M286	6.48	No	Yes	0	6	5
20	R:R:L289	R:R:L43	4.15	Yes	Yes	1	6	6
21	R:R:L43	R:R:M293	8.48	Yes	No	0	6	6
22	R:R:E50	R:R:L46	3.98	No	No	0	8	4
23	R:R:L46	R:R:M293	5.65	No	No	0	4	6
24	R:R:S47	R:R:S84	4.89	No	No	0	7	8
25	R:R:E50	R:R:P296	3.14	No	No	0	8	9
26	R:R:D80	R:R:N51	12.12	No	No	0	9	9
27	R:R:F81	R:R:N51	6.04	Yes	No	0	7	9
28	R:R:N51	R:R:P296	4.89	No	No	0	9	9
29	R:R:F81	R:R:V52	3.93	Yes	No	0	7	5
30	R:R:I58	R:R:V54	3.07	Yes	No	0	8	9
31	R:R:A77	R:R:L55	4.73	No	No	0	9	7
32	R:R:G78	R:R:L55	5.13	No	No	0	7	7
33	R:R:S60	R:R:Y56	15.26	No	No	0	5	5
34	R:R:L57	R:R:S309	6.01	No	No	0	8	7
35	R:R:A310	R:R:L57	3.15	No	No	0	6	8
36	R:R:I58	R:R:L64	5.71	Yes	Yes	0	8	8
37	R:R:L59	R:R:R65	4.86	No	No	0	4	3
38	R:R:L64	R:R:S61	9.01	Yes	No	0	8	7
39	R:R:S309	R:R:S61	4.89	No	No	0	7	7
40	R:R:Q63	R:R:R66	15.19	No	No	0	6	7
41	R:R:L64	R:R:Y70	15.24	Yes	Yes	2	8	8
42	R:R:E305	R:R:L64	3.98	Yes	Yes	2	6	8
43	R:R:K67	R:R:Y70	8.36	No	Yes	2	6	8
44	R:R:E305	R:R:K67	10.8	Yes	No	2	6	6
45	R:R:L145	R:R:P68	6.57	No	No	0	6	5
46	R:R:A150	R:R:P68	3.74	No	No	0	7	5
47	R:R:D130	R:R:S69	4.42	Yes	No	0	9	8
48	R:R:S303	R:R:Y70	8.9	No	Yes	2	8	8
49	R:R:E305	R:R:Y70	14.59	Yes	Yes	2	6	8
50	R:R:I306	R:R:Y70	7.25	Yes	Yes	2	8	8
51	R:R:F72	R:R:L71	3.65	Yes	No	0	8	4
52	R:R:A150	R:R:L71	4.73	No	No	0	7	4
53	R:R:L151	R:R:L71	4.15	No	No	0	1	4
54	R:R:F72	R:R:L126	10.96	Yes	Yes	0	8	6
55	R:R:D130	R:R:F72	3.58	Yes	Yes	0	9	8
56	R:R:F72	R:R:L154	9.74	Yes	Yes	0	8	8
57	R:R:I73	R:R:T127	3.04	No	No	0	8	9
58	R:R:S123	R:R:S75	3.26	No	No	0	8	9
59	R:R:L154	R:R:S75	9.01	Yes	No	5	8	9
60	R:R:S75	R:R:W158	6.18	No	Yes	5	9	9
61	R:R:L76	R:R:S123	7.51	No	No	0	9	8
62	R:R:L124	R:R:L76	5.54	No	No	1	8	9
63	R:R:L76	R:R:Y299	4.69	No	Yes	1	9	9
64	R:R:D80	R:R:S292	8.83	No	No	0	9	9
65	R:R:D80	R:R:N295	9.42	No	No	0	9	9
66	R:R:F81	R:R:V85	7.87	Yes	No	0	7	4
67	R:R:A83	R:R:T116	3.36	No	Yes	0	8	7
68	R:R:V113	R:R:V86	4.81	No	No	0	5	4
69	R:R:T116	R:R:V86	3.17	Yes	No	0	7	4
70	R:R:F87	R:R:V113	7.87	Yes	No	1	6	5
71	R:R:F117	R:R:F87	5.36	Yes	Yes	1	6	6
72	R:R:F87	R:R:L289	4.87	Yes	Yes	1	6	6
73	L:L:?1	R:R:F87	15.54	Yes	Yes	1	0	6
74	R:R:K109	R:R:S90	9.18	No	No	0	5	4
75	R:R:F91	R:R:H95	12.44	No	Yes	0	6	4
76	R:R:F91	R:R:M286	3.73	No	Yes	0	6	5
77	R:R:V92	R:R:V96	3.21	No	No	0	5	4
78	R:R:F106	R:R:F94	12.86	Yes	Yes	0	9	3
79	L:L:?1	R:R:F94	3.45	Yes	Yes	0	0	3
80	R:R:D101	R:R:V105	8.76	No	No	0	2	4
81	R:R:D101	R:R:K109	4.15	No	No	0	2	5
82	R:R:S102	R:R:V105	4.85	No	No	0	6	4
83	R:R:F106	R:R:I110	8.79	Yes	No	0	9	4
84	R:R:F106	R:R:P184	7.22	Yes	No	0	9	5
85	R:R:F106	R:R:L185	3.65	Yes	No	0	9	4
86	R:R:L107	R:R:P168	4.93	No	No	0	5	5
87	R:R:L108	R:R:S112	3	No	No	0	4	4
88	R:R:L108	R:R:L169	6.92	No	No	0	4	6
89	L:L:?1	R:R:I110	8.09	Yes	No	0	0	4
90	R:R:S112	R:R:Y166	6.36	No	No	0	4	4
91	L:L:?1	R:R:V113	3.17	Yes	No	1	0	5
92	R:R:S165	R:R:T114	7.99	No	No	0	7	4
93	R:R:T114	R:R:W194	6.06	No	Yes	1	4	5
94	L:L:?1	R:R:T114	10.45	Yes	No	1	0	4
95	R:R:M115	R:R:T116	3.01	Yes	Yes	0	5	7
96	R:R:M115	R:R:S165	4.6	Yes	No	0	5	7
97	R:R:M115	R:R:Y166	10.78	Yes	No	0	5	4
98	R:R:F117	R:R:W258	9.02	Yes	Yes	1	6	8
99	R:R:C288	R:R:F117	8.38	No	Yes	1	7	6
100	L:L:?1	R:R:F117	4.32	Yes	Yes	1	0	6
101	R:R:S161	R:R:T118	3.2	No	No	0	8	6
102	R:R:T118	R:R:W194	7.28	No	Yes	0	6	5
103	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
104	R:R:A119	R:R:S161	3.42	No	No	0	7	8
105	R:R:I198	R:R:V121	3.07	No	No	1	7	8
106	R:R:L201	R:R:V121	5.96	No	No	0	7	8
107	R:R:F202	R:R:V121	7.87	Yes	No	1	7	8
108	R:R:G122	R:R:M157	5.24	No	No	0	5	6
109	R:R:L124	R:R:L254	4.15	No	Yes	1	8	9
110	R:R:L124	R:R:Y299	8.21	No	Yes	1	8	9
111	R:R:L126	R:R:T153	4.42	Yes	No	0	6	6
112	R:R:L126	R:R:M157	4.24	Yes	No	0	6	6
113	R:R:R131	R:R:T127	5.17	No	No	1	9	9
114	R:R:T127	R:R:Y299	4.99	No	Yes	1	9	9
115	R:R:A128	R:R:Y209	6.67	No	Yes	0	9	9
116	R:R:D130	R:R:Y141	9.2	Yes	No	0	9	7
117	R:R:D130	R:R:L145	6.79	Yes	No	0	9	6
118	R:R:R131	R:R:Y209	7.2	No	Yes	0	9	9
119	R:R:R131	R:R:Y299	11.32	No	Yes	1	9	9
120	R:R:R136	R:R:Y132	9.26	No	Yes	6	6	8
121	R:R:T208	R:R:Y132	4.99	No	Yes	0	6	8
122	R:R:H211	R:R:Y132	5.44	No	Yes	0	5	8
123	R:R:K215	R:R:Y132	5.97	Yes	Yes	6	6	8
124	R:R:L133	R:R:L144	5.54	No	No	0	5	4
125	R:R:C134	R:R:Y141	8.06	No	No	0	8	7
126	R:R:R136	R:R:Y137	26.75	No	Yes	0	6	5
127	R:R:K215	R:R:R136	8.66	Yes	No	6	6	6
128	R:R:S140	R:R:Y137	3.82	No	Yes	0	5	5
129	R:R:L144	R:R:Y137	4.69	No	Yes	0	4	5
130	R:R:P138	R:R:P139	7.79	No	No	0	8	7
131	R:R:K142	R:R:Y141	7.17	No	No	0	5	7
132	R:R:R149	R:R:T146	3.88	No	No	0	6	9
133	R:R:G148	R:R:R147	3	No	No	0	4	3
134	R:R:L151	R:R:R147	4.86	No	No	0	1	3
135	R:R:L154	R:R:W158	4.56	Yes	Yes	5	8	9
136	R:R:M157	R:R:S161	3.07	No	No	0	6	8
137	R:R:L160	R:R:L163	4.15	No	No	0	4	3
138	R:R:L163	R:R:V164	4.47	No	No	0	3	5
139	R:R:F197	R:R:V164	10.49	No	No	0	5	5
140	R:R:P168	R:R:Y190	6.95	No	Yes	0	5	7
141	R:R:L169	R:R:M170	4.24	No	No	0	6	4
142	R:R:P176	R:R:W172	9.46	No	No	0	4	5
143	R:R:P187	R:R:W172	8.11	No	No	0	4	5
144	R:R:C175	R:R:T173	5.07	No	No	0	3	5
145	R:R:C174	R:R:C179	7.28	No	No	0	5	9
146	R:R:C174	R:R:P187	7.53	No	No	0	5	4
147	R:R:D189	R:R:R177	7.15	No	No	0	4	3
148	R:R:N188	R:R:P178	3.26	No	No	0	4	4
149	R:R:N188	R:R:S180	5.96	No	No	0	4	4
150	R:R:L191	R:R:S180	3	No	No	0	5	4
151	R:R:E181	R:R:L182	5.3	No	Yes	0	4	4
152	R:R:E181	R:R:K278	6.75	No	No	0	4	2
153	R:R:L182	R:R:S268	4.5	Yes	No	0	4	3
154	R:R:L182	R:R:L273	4.15	Yes	Yes	0	4	1
155	R:R:F281	R:R:L182	6.09	Yes	Yes	0	4	4
156	R:R:F183	R:R:I186	3.77	Yes	Yes	1	6	5
157	R:R:F183	R:R:M265	7.46	Yes	Yes	0	6	6
158	R:R:F183	R:R:F281	6.43	Yes	Yes	1	6	4
159	L:L:?1	R:R:F183	25.9	Yes	Yes	1	0	6
160	L:L:?1	R:R:P184	8.15	Yes	No	0	0	5
161	R:R:I186	R:R:P187	3.39	Yes	No	0	5	4
162	R:R:I186	R:R:Y190	4.84	Yes	Yes	0	5	7
163	L:L:?1	R:R:I186	3.04	Yes	Yes	1	0	5
164	R:R:S193	R:R:Y190	6.36	No	Yes	0	5	7
165	R:R:W194	R:R:Y190	4.82	Yes	Yes	0	5	7
166	R:R:L191	R:R:M265	4.24	No	Yes	0	5	6
167	R:R:L191	R:R:S268	3	No	No	0	5	3
168	R:R:L192	R:R:L269	4.15	No	No	0	4	3
169	R:R:I198	R:R:W194	7.05	No	Yes	1	7	5
170	R:R:M265	R:R:W194	3.49	Yes	Yes	0	6	5
171	L:L:?1	R:R:W194	5.65	Yes	Yes	1	0	5
172	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
173	R:R:F202	R:R:I198	3.77	Yes	No	1	7	7
174	R:R:F202	R:R:L254	3.65	Yes	Yes	1	7	9
175	R:R:F202	R:R:W258	7.02	Yes	Yes	1	7	8
176	R:R:F202	R:R:L262	3.65	Yes	No	1	7	6
177	R:R:I205	R:R:Y209	3.63	No	Yes	0	8	9
178	R:R:I206	R:R:L251	5.71	No	No	0	5	7
179	R:R:H211	R:R:Y207	7.62	No	No	0	5	4
180	R:R:L247	R:R:Y209	14.07	No	Yes	0	8	9
181	R:R:L251	R:R:Y209	8.21	No	Yes	0	7	9
182	R:R:L213	R:R:L247	4.15	No	No	0	6	8
183	R:R:Q218	R:R:W214	6.57	No	No	0	5	3
184	R:R:D240	R:R:H217	7.56	No	No	0	7	5
185	R:R:L239	R:R:V220	4.47	Yes	No	0	5	5
186	R:R:D240	R:R:V220	11.69	No	No	0	7	5
187	R:R:M237	R:R:V241	3.04	No	No	0	4	5
188	R:R:R238	R:R:R242	11.73	No	No	0	4	8
189	R:R:K245	R:R:V241	4.55	No	No	0	7	5
190	R:R:R302	R:R:T246	15.52	No	No	0	7	8
191	R:R:I298	R:R:L249	4.28	Yes	No	0	9	6
192	R:R:V250	R:R:Y299	8.83	No	Yes	0	8	9
193	R:R:I298	R:R:V253	4.61	Yes	No	0	9	7
194	R:R:L254	R:R:W258	3.42	Yes	Yes	1	9	8
195	R:R:C257	R:R:L287	3.17	Yes	No	7	8	8
196	R:R:C257	R:R:I290	3.27	Yes	No	7	8	4
197	R:R:C257	R:R:N291	6.3	Yes	No	0	8	9
198	R:R:L262	R:R:W258	4.56	No	Yes	1	6	8
199	R:R:C288	R:R:W258	7.84	No	Yes	1	7	8
200	R:R:N291	R:R:W258	6.78	No	Yes	0	9	8
201	R:R:L287	R:R:P260	3.28	No	No	0	8	9
202	R:R:F281	R:R:V261	5.24	Yes	No	0	4	6
203	R:R:F281	R:R:L264	7.31	Yes	No	0	4	4
204	R:R:H267	R:R:L273	7.71	No	Yes	0	4	1
205	R:R:L273	R:R:T271	4.42	Yes	No	0	1	3
206	R:R:S274	R:R:T272	3.2	No	No	0	2	1
207	R:R:L273	R:R:V277	7.45	Yes	No	0	1	3
208	R:R:K279	R:R:Q276	17.63	No	No	0	2	3
209	R:R:F281	R:R:S285	7.93	Yes	No	1	4	5
210	L:L:?1	R:R:F281	10.36	Yes	Yes	1	0	4
211	L:L:?1	R:R:S285	6.39	Yes	No	1	0	5
212	R:R:L289	R:R:M286	4.24	Yes	Yes	0	6	5
213	R:R:I290	R:R:L287	5.71	No	No	7	4	8
214	R:R:I290	R:R:M293	4.37	No	No	0	4	6
215	R:R:N291	R:R:N295	8.17	No	No	0	9	9
216	R:R:I298	R:R:V294	4.61	Yes	No	0	9	6
217	R:R:L301	R:R:V297	4.47	No	No	0	6	6
218	R:R:A300	R:R:I306	3.25	No	Yes	0	8	8
219	R:R:I306	R:R:S303	6.19	Yes	No	2	8	8
220	R:R:G304	R:R:R307	3	No	No	0	4	8
221	R:R:L108	R:R:V105	2.98	No	No	0	4	4
222	R:R:L135	R:R:V212	2.98	No	No	0	9	9
223	R:R:L247	R:R:V212	2.98	No	No	0	8	9
224	R:R:L82	R:R:T116	2.95	No	Yes	0	7	7
225	R:R:I58	R:R:I73	2.94	Yes	No	0	8	8
226	R:R:A282	R:R:H95	2.93	No	Yes	0	4	4
227	R:R:D275	R:R:V277	2.92	No	No	0	3	3
228	R:R:G111	R:R:Y166	2.9	No	No	0	6	4
229	R:R:Q227	R:R:S224	2.89	No	No	0	2	4
230	R:R:K23	R:R:M26	2.88	No	Yes	0	4	6
231	R:R:P178	R:R:R177	2.88	No	No	0	4	3
232	R:R:I129	R:R:L126	2.85	No	Yes	0	6	6
233	R:R:K215	R:R:L135	2.82	Yes	No	0	6	9
234	R:R:D24	R:R:I27	2.8	No	No	0	4	5
235	R:R:C284	R:R:F281	2.79	No	Yes	0	4	4
236	R:R:L42	R:R:L46	2.77	No	No	0	4	4
237	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
238	R:R:L125	R:R:L201	2.77	No	No	0	6	7
239	R:R:L239	R:R:L243	2.77	Yes	No	0	5	7
240	R:R:A263	R:R:F259	2.77	No	No	0	5	5
241	R:R:R149	R:R:V152	2.62	No	No	0	6	3
242	R:R:A79	R:R:W158	2.59	No	Yes	0	8	9
243	R:R:F197	R:R:T118	2.59	No	No	0	5	6
244	R:R:H219	R:R:L239	2.57	No	Yes	0	7	5
245	R:R:F94	R:R:M22	2.49	Yes	No	0	3	7
246	R:R:L239	R:R:R242	2.43	Yes	No	0	5	8
247	R:R:L249	R:R:R302	2.43	No	No	0	6	7
248	R:R:I298	R:R:Y299	2.42	Yes	Yes	0	9	9
249	R:R:R302	R:R:R307	2.13	No	No	0	7	8
250	R:R:A88	R:R:G44	1.95	No	Yes	0	6	7
251	R:R:A77	R:R:G74	1.95	No	No	0	9	7
252	R:R:C175	R:R:P176	1.88	No	No	0	3	4
253	R:R:G30	R:R:S29	1.86	No	No	0	4	7
254	R:R:G44	R:R:S47	1.86	Yes	No	0	7	7
255	R:R:G148	R:R:T146	1.82	No	No	0	4	9
256	R:R:G74	R:R:I58	1.76	No	Yes	0	7	8
257	R:R:G171	R:R:M170	1.75	No	No	0	4	4
258	R:R:C40	R:R:V36	1.71	No	No	0	6	5
259	R:R:C40	R:R:V92	1.71	No	No	0	6	5
260	R:R:G44	R:R:L43	1.71	Yes	Yes	1	7	6
261	R:R:G44	R:R:L289	1.71	Yes	Yes	1	7	6
262	R:R:A48	R:R:S84	1.71	No	No	0	6	8
263	R:R:A79	R:R:S120	1.71	No	No	0	8	9
264	R:R:A104	R:R:S102	1.71	No	No	0	1	6
265	R:R:G204	R:R:L125	1.71	No	No	0	5	6
266	R:R:G155	R:R:L154	1.71	No	Yes	0	4	8
267	R:R:A221	R:R:S224	1.71	No	No	0	5	4
268	R:R:A270	R:R:T271	1.68	No	No	0	4	3
269	R:R:L167	R:R:P168	1.64	No	No	0	5	5
270	R:R:C257	R:R:I256	1.64	Yes	No	0	8	5
271	R:R:A162	R:R:M115	1.61	No	Yes	0	3	5
272	R:R:A216	R:R:L135	1.58	No	No	0	8	9
273	R:R:A266	R:R:L195	1.58	No	No	0	5	4
274	R:R:A244	R:R:L213	1.58	No	No	0	8	6
275	R:R:A216	R:R:L243	1.58	No	No	0	8	7
276	R:R:M26	R:R:V100	1.52	Yes	No	0	6	4
277	R:R:D275	R:R:S274	1.47	No	No	0	3	2
278	R:R:K103	R:R:M22	1.44	No	No	0	3	7
279	R:R:Q63	R:R:S61	1.44	No	No	0	6	7
280	R:R:F259	R:R:P260	1.44	No	No	0	5	9
281	R:R:E305	R:R:S308	1.44	Yes	No	0	6	4
282	R:R:I306	R:R:L301	1.43	Yes	No	0	8	6
283	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
284	R:R:L45	R:R:L49	1.38	No	No	0	5	4
285	R:R:L254	R:R:L255	1.38	Yes	No	0	9	6
286	R:R:L223	R:R:Q227	1.33	No	No	0	6	2
287	R:R:F97	R:R:V96	1.31	No	No	0	3	4
288	R:R:H219	R:R:L223	1.29	No	No	0	7	6
289	R:R:M237	R:R:R238	1.24	No	No	0	4	4
290	R:R:H311	R:R:H312	1.19	No	No	0	4	5
291	R:R:K215	R:R:W214	1.16	Yes	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M26	3.9675	4	0	6
2	R:R:L28	7.3975	4	4	6
3	R:R:L43	4.6225	4	1	6
4	R:R:G44	1.8075	4	1	7
5	R:R:I58	3.37	4	0	8
6	R:R:L64	8.485	4	2	8
7	R:R:Y70	10.868	5	2	8
8	R:R:F72	6.9825	4	0	8
9	R:R:F81	5.1525	4	0	7
10	R:R:F87	8.41	4	1	6
11	R:R:F94	6.255	4	0	3
12	R:R:H95	7.075	4	0	4
13	R:R:F106	8.13	4	0	9
14	R:R:M115	5	4	0	5
15	R:R:T116	3.1225	4	0	7
16	R:R:F117	6.77	4	1	6
17	R:R:L126	5.6175	4	0	6
18	R:R:D130	5.9975	4	0	9
19	R:R:Y132	6.415	4	6	8
20	R:R:Y137	9.1625	4	0	5
21	R:R:L154	6.255	4	5	8
22	R:R:W158	5.2775	4	5	9
23	R:R:L182	5.01	4	0	4
24	R:R:F183	10.89	4	1	6
25	R:R:I186	3.76	4	1	5
26	R:R:Y190	5.7425	4	0	7
27	R:R:W194	5.725	6	1	5
28	R:R:F202	5.192	5	1	7
29	R:R:Y209	7.956	5	0	9
30	R:R:K215	4.6525	4	6	6
31	R:R:L239	3.06	4	0	5
32	R:R:L254	3.15	4	1	9
33	R:R:C257	3.595	4	7	8
34	R:R:W258	6.44	6	1	8
35	R:R:M265	5.21	4	0	6
36	R:R:L273	5.9325	4	0	1
37	R:R:F281	6.59286	7	1	4
38	R:R:M286	4.6725	4	0	5
39	R:R:L289	3.7425	4	1	6
40	R:R:I298	3.98	4	0	9
41	R:R:Y299	6.74333	6	1	9
42	R:R:E305	7.7025	4	2	6
43	R:R:I306	4.53	4	2	8
44	L:L:?1	8.70917	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M26	16.8519	6.22	Yes	Yes	0	3	6
2	L:L:?1	R:R:F94	24.1141	3.45	Yes	Yes	0	0	3
3	R:R:H98	R:R:M26	11.9242	5.25	No	Yes	0	4	6
4	R:R:E181	R:R:L182	10.7919	5.3	No	Yes	0	4	4
5	R:R:F281	R:R:L182	26.9099	6.09	Yes	Yes	0	4	4
6	L:L:?1	R:R:F281	30.3418	10.36	Yes	Yes	1	0	4
7	R:R:H95	R:R:L28	10.6521	9	Yes	Yes	0	4	6
8	R:R:F91	R:R:H95	12.9797	12.44	No	Yes	0	6	4
9	R:R:F91	R:R:M286	14.6292	3.73	No	Yes	0	6	5
10	R:R:L289	R:R:M286	26.6862	4.24	Yes	Yes	0	6	5
11	R:R:F87	R:R:L289	44.5936	4.87	Yes	Yes	1	6	6
12	L:L:?1	R:R:F87	25.6588	15.54	Yes	Yes	1	0	6
13	R:R:C40	R:R:M286	12.4764	6.48	No	Yes	0	6	5
14	R:R:L289	R:R:L43	11.435	4.15	Yes	Yes	1	6	6
15	R:R:L43	R:R:M293	10.4145	8.48	Yes	No	0	6	6
16	R:R:G44	R:R:L289	11.7565	1.71	Yes	Yes	1	7	6
17	L:L:?1	R:R:F117	56.5318	4.32	Yes	Yes	1	0	6
18	R:R:F117	R:R:W258	74.0477	9.02	Yes	Yes	1	6	8
19	R:R:N291	R:R:W258	32.7742	6.78	No	Yes	0	9	8
20	R:R:N291	R:R:N295	16.2578	8.17	No	No	0	9	9
21	R:R:D80	R:R:N295	14.2937	9.42	No	No	0	9	9
22	R:R:D80	R:R:N51	10.4774	12.12	No	No	0	9	9
23	R:R:I58	R:R:I73	41.8746	2.94	Yes	No	0	8	8
24	R:R:I73	R:R:T127	43.5521	3.04	No	No	0	8	9
25	R:R:T127	R:R:Y299	38.0653	4.99	No	Yes	1	9	9
26	R:R:L124	R:R:Y299	92.7238	8.21	No	Yes	1	8	9
27	R:R:L124	R:R:L254	100	4.15	No	Yes	1	8	9
28	R:R:L254	R:R:W258	75.187	3.42	Yes	Yes	1	9	8
29	R:R:L64	R:R:S61	11.7355	9.01	Yes	No	0	8	7
30	R:R:I58	R:R:L64	31.7467	5.71	Yes	Yes	0	8	8
31	R:R:L64	R:R:Y70	13.4829	15.24	Yes	Yes	2	8	8
32	R:R:D130	R:R:F72	12.6162	3.58	Yes	Yes	0	9	8
33	R:R:F72	R:R:L126	20.4795	10.96	Yes	Yes	0	8	6
34	R:R:L126	R:R:M157	22.3247	4.24	Yes	No	0	6	6
35	R:R:M157	R:R:S161	24.7152	3.07	No	No	0	6	8
36	R:R:S161	R:R:T118	32.2779	3.2	No	No	0	8	6
37	R:R:T118	R:R:W194	40.1272	7.28	No	Yes	0	6	5
38	L:L:?1	R:R:W194	35.3114	5.65	Yes	Yes	1	0	5
39	R:R:F72	R:R:L71	16.6003	3.65	Yes	No	0	8	4
40	R:R:L151	R:R:L71	11.1903	4.15	No	No	0	1	4
41	R:R:L76	R:R:S123	23.2404	7.51	No	No	0	9	8
42	R:R:T116	R:R:V86	10.9806	3.17	Yes	No	0	7	4
43	R:R:V113	R:R:V86	13.3291	4.81	No	No	0	5	4
44	R:R:L108	R:R:V105	15.8035	2.98	No	No	0	4	4
45	R:R:L108	R:R:S112	26.0642	3	No	No	0	4	4
46	R:R:S112	R:R:Y166	28.5944	6.36	No	No	0	4	4
47	R:R:M115	R:R:Y166	33.585	10.78	Yes	No	0	5	4
48	R:R:M115	R:R:S165	35.9195	4.6	Yes	No	0	5	7
49	R:R:S165	R:R:T114	38.1002	7.99	No	No	0	7	4
50	L:L:?1	R:R:T114	22.3317	10.45	Yes	No	1	0	4
51	L:L:?1	R:R:I186	17.0336	3.04	Yes	Yes	1	0	5
52	R:R:W194	R:R:Y190	11.9172	4.82	Yes	Yes	0	5	7
53	R:R:I198	R:R:W194	31.7816	7.05	No	Yes	1	7	5
54	R:R:F202	R:R:I198	26.868	3.77	Yes	No	1	7	7
55	R:R:R131	R:R:Y299	62.6686	11.32	No	Yes	1	9	9
56	R:R:R131	R:R:Y209	68.5259	7.2	No	Yes	0	9	9
57	R:R:L247	R:R:Y209	61.3965	14.07	No	Yes	0	8	9
58	R:R:L247	R:R:V212	56.7834	2.98	No	No	0	8	9
59	R:R:L135	R:R:V212	55.2177	2.98	No	No	0	9	9
60	R:R:K215	R:R:L135	26.5814	2.82	Yes	No	0	6	9
61	R:R:K215	R:R:R136	13.441	8.66	Yes	No	6	6	6
62	R:R:R136	R:R:Y137	11.7355	26.75	No	Yes	0	6	5
63	R:R:I186	R:R:P187	15.8454	3.39	Yes	No	0	5	4
64	R:R:N188	R:R:S180	10.2258	5.96	No	No	0	4	4
65	R:R:L191	R:R:S180	12.749	3	No	No	0	5	4
66	R:R:L191	R:R:M265	15.6567	4.24	No	Yes	0	5	6
67	R:R:M265	R:R:W194	16.5374	3.49	Yes	Yes	0	6	5
68	R:R:L182	R:R:L273	15.426	4.15	Yes	Yes	0	4	1
69	R:R:L239	R:R:L243	26.5954	2.77	Yes	No	0	5	7
70	R:R:A216	R:R:L243	28.3777	1.58	No	No	0	8	7
71	R:R:A216	R:R:L135	30.1601	1.58	No	No	0	8	9
72	R:R:I298	R:R:Y299	15.4749	2.42	Yes	Yes	0	9	9
73	R:R:C257	R:R:N291	15.7196	6.3	Yes	No	0	8	9
74	R:R:F117	R:R:F87	18.9977	5.36	Yes	Yes	1	6	6
75	R:R:S123	R:R:S75	21.9962	3.26	No	No	0	8	9
76	R:R:L154	R:R:S75	16.5513	9.01	Yes	No	5	8	9
77	R:R:F72	R:R:L154	15.8035	9.74	Yes	Yes	0	8	8
78	R:R:L76	R:R:Y299	17.9632	4.69	No	Yes	1	9	9
79	R:R:F202	R:R:L254	25.8405	3.65	Yes	Yes	1	7	9
80	R:R:T114	R:R:W194	17.7535	6.06	No	Yes	1	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P184	R:R:Y25	18.08	0	No	No	5	4	1	2
R:R:F94	R:R:M26	6.22	0	Yes	Yes	3	6	1	2
R:R:V113	R:R:V86	4.81	1	No	No	5	4	1	2
R:R:F87	R:R:V113	7.87	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	5.36	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:L289	4.87	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:F87	15.54	1	Yes	Yes	0	6	0	1
R:R:F106	R:R:F94	12.86	0	Yes	Yes	9	3	2	1
L:L:?1	R:R:F94	3.45	1	Yes	Yes	0	3	0	1
R:R:F106	R:R:I110	8.79	0	Yes	No	9	4	2	1
R:R:F106	R:R:P184	7.22	0	Yes	No	9	5	2	1
L:L:?1	R:R:I110	8.09	1	Yes	No	0	4	0	1
L:L:?1	R:R:V113	3.17	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	7.99	0	No	No	7	4	2	1
R:R:T114	R:R:W194	6.06	1	No	Yes	4	5	1	1
L:L:?1	R:R:T114	10.45	1	Yes	No	0	4	0	1
R:R:F117	R:R:W258	9.02	1	Yes	Yes	6	8	1	2
R:R:C288	R:R:F117	8.38	1	No	Yes	7	6	2	1
L:L:?1	R:R:F117	4.32	1	Yes	Yes	0	6	0	1
R:R:T118	R:R:W194	7.28	0	No	Yes	6	5	2	1
R:R:F281	R:R:L182	6.09	1	Yes	Yes	4	4	1	2
R:R:F183	R:R:I186	3.77	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:M265	7.46	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	6.43	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F183	25.9	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	8.15	1	Yes	No	0	5	0	1
R:R:I186	R:R:P187	3.39	1	Yes	No	5	4	1	2
R:R:I186	R:R:Y190	4.84	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:I186	3.04	1	Yes	Yes	0	5	0	1
R:R:W194	R:R:Y190	4.82	1	Yes	Yes	5	7	1	2
R:R:I198	R:R:W194	7.05	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	0	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	5.65	1	Yes	Yes	0	5	0	1
R:R:C288	R:R:W258	7.84	1	No	Yes	7	8	2	2
R:R:F281	R:R:V261	5.24	1	Yes	No	4	6	1	2
R:R:F281	R:R:L264	7.31	1	Yes	No	4	4	1	2
R:R:F281	R:R:S285	7.93	1	Yes	No	4	5	1	1
L:L:?1	R:R:F281	10.36	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S285	6.39	1	Yes	No	0	5	0	1
R:R:C284	R:R:F281	2.79	0	No	Yes	4	4	2	1
R:R:F94	R:R:M22	2.49	0	Yes	No	3	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	260
Number of Links	291
Number of Hubs	44
Number of Links mediated by Hubs	156
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	39145
Length Of Smallest Path	3
Average Path Length	12.0204
Length of Longest Path	29
Minimum Path Strength	1.31
Average Path Strength	5.8533
Maximum Path Strength	18.005
Minimum Path Correlation	0.7
Average Path Correlation	0.923415
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	51.4723
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2593
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • cannabinoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • regulation of action potential • negative regulation of action potential • negative regulation of biological process • action potential • regulation of biological quality • regulation of membrane potential • immune response • immune system process • response to amine • response to chemical • response to nitrogen compound • response to amphetamine • defense response • response to stress • inflammatory response • multicellular organismal process • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • negative regulation of cellular process • mast cell activation • regulation of mast cell activation • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • cell chemotaxis • chemotaxis • response to external stimulus • leukocyte migration • cellular response to chemical stimulus • taxis • cell migration • cell motility • leukocyte chemotaxis • locomotion • trans-synaptic signaling • regulation of signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • regulation of cell communication • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • negative regulation of synaptic transmission, GABAergic • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dendrite • dendritic tree • endoplasmic reticulum • endomembrane system • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9GF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9GF
Name	2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
Synonyms
Identifier
Formula	C24 H40 O3
Molecular Weight	376.573
SMILES
PubChem	104895
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	3
Total Bonds	68
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUR_nogp_Chain_R M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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