psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P184	R:R:Y25	18.08	No	No	0	5	4
2	R:R:F94	R:R:M26	6.22	Yes	Yes	0	3	6
3	R:R:H98	R:R:M26	5.25	No	Yes	0	4	6
4	R:R:I27	R:R:K278	8.72	No	No	0	5	2
5	R:R:I27	R:R:K279	5.82	No	No	0	5	2
6	R:R:L28	R:R:Q32	3.99	Yes	No	4	6	5
7	R:R:H95	R:R:L28	9	Yes	Yes	0	4	6
8	R:R:K279	R:R:L28	5.64	No	Yes	0	2	6
9	R:R:F283	R:R:L28	10.96	No	Yes	4	4	6
10	R:R:K33	R:R:S29	9.18	No	No	3	5	7
11	R:R:H98	R:R:S29	4.18	No	No	3	4	7
12	R:R:G30	R:R:P31	4.06	No	No	0	4	4
13	R:R:F283	R:R:Q32	11.71	No	No	4	4	5
14	R:R:H95	R:R:K33	3.93	Yes	No	0	4	5
15	R:R:H98	R:R:K33	10.48	No	No	3	4	5
16	R:R:A37	R:R:V96	5.09	No	No	0	5	4
17	R:R:L39	R:R:L43	4.15	No	Yes	0	5	6
18	R:R:L39	R:R:M286	4.24	No	Yes	0	5	5
19	R:R:C40	R:R:M286	6.48	No	Yes	0	6	5
20	R:R:L289	R:R:L43	4.15	Yes	Yes	1	6	6
21	R:R:L43	R:R:M293	8.48	Yes	No	0	6	6
22	R:R:E50	R:R:L46	3.98	No	No	0	8	4
23	R:R:L46	R:R:M293	5.65	No	No	0	4	6
24	R:R:S47	R:R:S84	4.89	No	No	0	7	8
25	R:R:E50	R:R:P296	3.14	No	No	0	8	9
26	R:R:D80	R:R:N51	12.12	No	No	0	9	9
27	R:R:F81	R:R:N51	6.04	Yes	No	0	7	9
28	R:R:N51	R:R:P296	4.89	No	No	0	9	9
29	R:R:F81	R:R:V52	3.93	Yes	No	0	7	5
30	R:R:I58	R:R:V54	3.07	Yes	No	0	8	9
31	R:R:A77	R:R:L55	4.73	No	No	0	9	7
32	R:R:G78	R:R:L55	5.13	No	No	0	7	7
33	R:R:S60	R:R:Y56	15.26	No	No	0	5	5
34	R:R:L57	R:R:S309	6.01	No	No	0	8	7
35	R:R:A310	R:R:L57	3.15	No	No	0	6	8
36	R:R:I58	R:R:L64	5.71	Yes	Yes	0	8	8
37	R:R:L59	R:R:R65	4.86	No	No	0	4	3
38	R:R:L64	R:R:S61	9.01	Yes	No	0	8	7
39	R:R:S309	R:R:S61	4.89	No	No	0	7	7
40	R:R:Q63	R:R:R66	15.19	No	No	0	6	7
41	R:R:L64	R:R:Y70	15.24	Yes	Yes	2	8	8
42	R:R:E305	R:R:L64	3.98	Yes	Yes	2	6	8
43	R:R:K67	R:R:Y70	8.36	No	Yes	2	6	8
44	R:R:E305	R:R:K67	10.8	Yes	No	2	6	6
45	R:R:L145	R:R:P68	6.57	No	No	0	6	5
46	R:R:A150	R:R:P68	3.74	No	No	0	7	5
47	R:R:D130	R:R:S69	4.42	Yes	No	0	9	8
48	R:R:S303	R:R:Y70	8.9	No	Yes	2	8	8
49	R:R:E305	R:R:Y70	14.59	Yes	Yes	2	6	8
50	R:R:I306	R:R:Y70	7.25	Yes	Yes	2	8	8
51	R:R:F72	R:R:L71	3.65	Yes	No	0	8	4
52	R:R:A150	R:R:L71	4.73	No	No	0	7	4
53	R:R:L151	R:R:L71	4.15	No	No	0	1	4
54	R:R:F72	R:R:L126	10.96	Yes	Yes	0	8	6
55	R:R:D130	R:R:F72	3.58	Yes	Yes	0	9	8
56	R:R:F72	R:R:L154	9.74	Yes	Yes	0	8	8
57	R:R:I73	R:R:T127	3.04	No	No	0	8	9
58	R:R:S123	R:R:S75	3.26	No	No	0	8	9
59	R:R:L154	R:R:S75	9.01	Yes	No	5	8	9
60	R:R:S75	R:R:W158	6.18	No	Yes	5	9	9
61	R:R:L76	R:R:S123	7.51	No	No	0	9	8
62	R:R:L124	R:R:L76	5.54	No	No	1	8	9
63	R:R:L76	R:R:Y299	4.69	No	Yes	1	9	9
64	R:R:D80	R:R:S292	8.83	No	No	0	9	9
65	R:R:D80	R:R:N295	9.42	No	No	0	9	9
66	R:R:F81	R:R:V85	7.87	Yes	No	0	7	4
67	R:R:A83	R:R:T116	3.36	No	Yes	0	8	7
68	R:R:V113	R:R:V86	4.81	No	No	0	5	4
69	R:R:T116	R:R:V86	3.17	Yes	No	0	7	4
70	R:R:F87	R:R:V113	7.87	Yes	No	1	6	5
71	R:R:F117	R:R:F87	5.36	Yes	Yes	1	6	6
72	R:R:F87	R:R:L289	4.87	Yes	Yes	1	6	6
73	L:L:?1	R:R:F87	15.54	Yes	Yes	1	0	6
74	R:R:K109	R:R:S90	9.18	No	No	0	5	4
75	R:R:F91	R:R:H95	12.44	No	Yes	0	6	4
76	R:R:F91	R:R:M286	3.73	No	Yes	0	6	5
77	R:R:V92	R:R:V96	3.21	No	No	0	5	4
78	R:R:F106	R:R:F94	12.86	Yes	Yes	0	9	3
79	L:L:?1	R:R:F94	3.45	Yes	Yes	0	0	3
80	R:R:D101	R:R:V105	8.76	No	No	0	2	4
81	R:R:D101	R:R:K109	4.15	No	No	0	2	5
82	R:R:S102	R:R:V105	4.85	No	No	0	6	4
83	R:R:F106	R:R:I110	8.79	Yes	No	0	9	4
84	R:R:F106	R:R:P184	7.22	Yes	No	0	9	5
85	R:R:F106	R:R:L185	3.65	Yes	No	0	9	4
86	R:R:L107	R:R:P168	4.93	No	No	0	5	5
87	R:R:L108	R:R:S112	3	No	No	0	4	4
88	R:R:L108	R:R:L169	6.92	No	No	0	4	6
89	L:L:?1	R:R:I110	8.09	Yes	No	0	0	4
90	R:R:S112	R:R:Y166	6.36	No	No	0	4	4
91	L:L:?1	R:R:V113	3.17	Yes	No	1	0	5
92	R:R:S165	R:R:T114	7.99	No	No	0	7	4
93	R:R:T114	R:R:W194	6.06	No	Yes	1	4	5
94	L:L:?1	R:R:T114	10.45	Yes	No	1	0	4
95	R:R:M115	R:R:T116	3.01	Yes	Yes	0	5	7
96	R:R:M115	R:R:S165	4.6	Yes	No	0	5	7
97	R:R:M115	R:R:Y166	10.78	Yes	No	0	5	4
98	R:R:F117	R:R:W258	9.02	Yes	Yes	1	6	8
99	R:R:C288	R:R:F117	8.38	No	Yes	1	7	6
100	L:L:?1	R:R:F117	4.32	Yes	Yes	1	0	6
101	R:R:S161	R:R:T118	3.2	No	No	0	8	6
102	R:R:T118	R:R:W194	7.28	No	Yes	0	6	5
103	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
104	R:R:A119	R:R:S161	3.42	No	No	0	7	8
105	R:R:I198	R:R:V121	3.07	No	No	1	7	8
106	R:R:L201	R:R:V121	5.96	No	No	0	7	8
107	R:R:F202	R:R:V121	7.87	Yes	No	1	7	8
108	R:R:G122	R:R:M157	5.24	No	No	0	5	6
109	R:R:L124	R:R:L254	4.15	No	Yes	1	8	9
110	R:R:L124	R:R:Y299	8.21	No	Yes	1	8	9
111	R:R:L126	R:R:T153	4.42	Yes	No	0	6	6
112	R:R:L126	R:R:M157	4.24	Yes	No	0	6	6
113	R:R:R131	R:R:T127	5.17	No	No	1	9	9
114	R:R:T127	R:R:Y299	4.99	No	Yes	1	9	9
115	R:R:A128	R:R:Y209	6.67	No	Yes	0	9	9
116	R:R:D130	R:R:Y141	9.2	Yes	No	0	9	7
117	R:R:D130	R:R:L145	6.79	Yes	No	0	9	6
118	R:R:R131	R:R:Y209	7.2	No	Yes	0	9	9
119	R:R:R131	R:R:Y299	11.32	No	Yes	1	9	9
120	R:R:R136	R:R:Y132	9.26	No	Yes	6	6	8
121	R:R:T208	R:R:Y132	4.99	No	Yes	0	6	8
122	R:R:H211	R:R:Y132	5.44	No	Yes	0	5	8
123	R:R:K215	R:R:Y132	5.97	Yes	Yes	6	6	8
124	R:R:L133	R:R:L144	5.54	No	No	0	5	4
125	R:R:C134	R:R:Y141	8.06	No	No	0	8	7
126	R:R:R136	R:R:Y137	26.75	No	Yes	0	6	5
127	R:R:K215	R:R:R136	8.66	Yes	No	6	6	6
128	R:R:S140	R:R:Y137	3.82	No	Yes	0	5	5
129	R:R:L144	R:R:Y137	4.69	No	Yes	0	4	5
130	R:R:P138	R:R:P139	7.79	No	No	0	8	7
131	R:R:K142	R:R:Y141	7.17	No	No	0	5	7
132	R:R:R149	R:R:T146	3.88	No	No	0	6	9
133	R:R:G148	R:R:R147	3	No	No	0	4	3
134	R:R:L151	R:R:R147	4.86	No	No	0	1	3
135	R:R:L154	R:R:W158	4.56	Yes	Yes	5	8	9
136	R:R:M157	R:R:S161	3.07	No	No	0	6	8
137	R:R:L160	R:R:L163	4.15	No	No	0	4	3
138	R:R:L163	R:R:V164	4.47	No	No	0	3	5
139	R:R:F197	R:R:V164	10.49	No	No	0	5	5
140	R:R:P168	R:R:Y190	6.95	No	Yes	0	5	7
141	R:R:L169	R:R:M170	4.24	No	No	0	6	4
142	R:R:P176	R:R:W172	9.46	No	No	0	4	5
143	R:R:P187	R:R:W172	8.11	No	No	0	4	5
144	R:R:C175	R:R:T173	5.07	No	No	0	3	5
145	R:R:C174	R:R:C179	7.28	No	No	0	5	9
146	R:R:C174	R:R:P187	7.53	No	No	0	5	4
147	R:R:D189	R:R:R177	7.15	No	No	0	4	3
148	R:R:N188	R:R:P178	3.26	No	No	0	4	4
149	R:R:N188	R:R:S180	5.96	No	No	0	4	4
150	R:R:L191	R:R:S180	3	No	No	0	5	4
151	R:R:E181	R:R:L182	5.3	No	Yes	0	4	4
152	R:R:E181	R:R:K278	6.75	No	No	0	4	2
153	R:R:L182	R:R:S268	4.5	Yes	No	0	4	3
154	R:R:L182	R:R:L273	4.15	Yes	Yes	0	4	1
155	R:R:F281	R:R:L182	6.09	Yes	Yes	0	4	4
156	R:R:F183	R:R:I186	3.77	Yes	Yes	1	6	5
157	R:R:F183	R:R:M265	7.46	Yes	Yes	0	6	6
158	R:R:F183	R:R:F281	6.43	Yes	Yes	1	6	4
159	L:L:?1	R:R:F183	25.9	Yes	Yes	1	0	6
160	L:L:?1	R:R:P184	8.15	Yes	No	0	0	5
161	R:R:I186	R:R:P187	3.39	Yes	No	0	5	4
162	R:R:I186	R:R:Y190	4.84	Yes	Yes	0	5	7
163	L:L:?1	R:R:I186	3.04	Yes	Yes	1	0	5
164	R:R:S193	R:R:Y190	6.36	No	Yes	0	5	7
165	R:R:W194	R:R:Y190	4.82	Yes	Yes	0	5	7
166	R:R:L191	R:R:M265	4.24	No	Yes	0	5	6
167	R:R:L191	R:R:S268	3	No	No	0	5	3
168	R:R:L192	R:R:L269	4.15	No	No	0	4	3
169	R:R:I198	R:R:W194	7.05	No	Yes	1	7	5
170	R:R:M265	R:R:W194	3.49	Yes	Yes	0	6	5
171	L:L:?1	R:R:W194	5.65	Yes	Yes	1	0	5
172	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
173	R:R:F202	R:R:I198	3.77	Yes	No	1	7	7
174	R:R:F202	R:R:L254	3.65	Yes	Yes	1	7	9
175	R:R:F202	R:R:W258	7.02	Yes	Yes	1	7	8
176	R:R:F202	R:R:L262	3.65	Yes	No	1	7	6
177	R:R:I205	R:R:Y209	3.63	No	Yes	0	8	9
178	R:R:I206	R:R:L251	5.71	No	No	0	5	7
179	R:R:H211	R:R:Y207	7.62	No	No	0	5	4
180	R:R:L247	R:R:Y209	14.07	No	Yes	0	8	9
181	R:R:L251	R:R:Y209	8.21	No	Yes	0	7	9
182	R:R:L213	R:R:L247	4.15	No	No	0	6	8
183	R:R:Q218	R:R:W214	6.57	No	No	0	5	3
184	R:R:D240	R:R:H217	7.56	No	No	0	7	5
185	R:R:L239	R:R:V220	4.47	Yes	No	0	5	5
186	R:R:D240	R:R:V220	11.69	No	No	0	7	5
187	R:R:M237	R:R:V241	3.04	No	No	0	4	5
188	R:R:R238	R:R:R242	11.73	No	No	0	4	8
189	R:R:K245	R:R:V241	4.55	No	No	0	7	5
190	R:R:R302	R:R:T246	15.52	No	No	0	7	8
191	R:R:I298	R:R:L249	4.28	Yes	No	0	9	6
192	R:R:V250	R:R:Y299	8.83	No	Yes	0	8	9
193	R:R:I298	R:R:V253	4.61	Yes	No	0	9	7
194	R:R:L254	R:R:W258	3.42	Yes	Yes	1	9	8
195	R:R:C257	R:R:L287	3.17	Yes	No	7	8	8
196	R:R:C257	R:R:I290	3.27	Yes	No	7	8	4
197	R:R:C257	R:R:N291	6.3	Yes	No	0	8	9
198	R:R:L262	R:R:W258	4.56	No	Yes	1	6	8
199	R:R:C288	R:R:W258	7.84	No	Yes	1	7	8
200	R:R:N291	R:R:W258	6.78	No	Yes	0	9	8
201	R:R:L287	R:R:P260	3.28	No	No	0	8	9
202	R:R:F281	R:R:V261	5.24	Yes	No	0	4	6
203	R:R:F281	R:R:L264	7.31	Yes	No	0	4	4
204	R:R:H267	R:R:L273	7.71	No	Yes	0	4	1
205	R:R:L273	R:R:T271	4.42	Yes	No	0	1	3
206	R:R:S274	R:R:T272	3.2	No	No	0	2	1
207	R:R:L273	R:R:V277	7.45	Yes	No	0	1	3
208	R:R:K279	R:R:Q276	17.63	No	No	0	2	3
209	R:R:F281	R:R:S285	7.93	Yes	No	1	4	5
210	L:L:?1	R:R:F281	10.36	Yes	Yes	1	0	4
211	L:L:?1	R:R:S285	6.39	Yes	No	1	0	5
212	R:R:L289	R:R:M286	4.24	Yes	Yes	0	6	5
213	R:R:I290	R:R:L287	5.71	No	No	7	4	8
214	R:R:I290	R:R:M293	4.37	No	No	0	4	6
215	R:R:N291	R:R:N295	8.17	No	No	0	9	9
216	R:R:I298	R:R:V294	4.61	Yes	No	0	9	6
217	R:R:L301	R:R:V297	4.47	No	No	0	6	6
218	R:R:A300	R:R:I306	3.25	No	Yes	0	8	8
219	R:R:I306	R:R:S303	6.19	Yes	No	2	8	8
220	R:R:G304	R:R:R307	3	No	No	0	4	8
221	R:R:L108	R:R:V105	2.98	No	No	0	4	4
222	R:R:L135	R:R:V212	2.98	No	No	0	9	9
223	R:R:L247	R:R:V212	2.98	No	No	0	8	9
224	R:R:L82	R:R:T116	2.95	No	Yes	0	7	7
225	R:R:I58	R:R:I73	2.94	Yes	No	0	8	8
226	R:R:A282	R:R:H95	2.93	No	Yes	0	4	4
227	R:R:D275	R:R:V277	2.92	No	No	0	3	3
228	R:R:G111	R:R:Y166	2.9	No	No	0	6	4
229	R:R:Q227	R:R:S224	2.89	No	No	0	2	4
230	R:R:K23	R:R:M26	2.88	No	Yes	0	4	6
231	R:R:P178	R:R:R177	2.88	No	No	0	4	3
232	R:R:I129	R:R:L126	2.85	No	Yes	0	6	6
233	R:R:K215	R:R:L135	2.82	Yes	No	0	6	9
234	R:R:D24	R:R:I27	2.8	No	No	0	4	5
235	R:R:C284	R:R:F281	2.79	No	Yes	0	4	4
236	R:R:L42	R:R:L46	2.77	No	No	0	4	4
237	R:R:A48	R:R:F81	2.77	No	Yes	0	6	7
238	R:R:L125	R:R:L201	2.77	No	No	0	6	7
239	R:R:L239	R:R:L243	2.77	Yes	No	0	5	7
240	R:R:A263	R:R:F259	2.77	No	No	0	5	5
241	R:R:R149	R:R:V152	2.62	No	No	0	6	3
242	R:R:A79	R:R:W158	2.59	No	Yes	0	8	9
243	R:R:F197	R:R:T118	2.59	No	No	0	5	6
244	R:R:H219	R:R:L239	2.57	No	Yes	0	7	5
245	R:R:F94	R:R:M22	2.49	Yes	No	0	3	7
246	R:R:L239	R:R:R242	2.43	Yes	No	0	5	8
247	R:R:L249	R:R:R302	2.43	No	No	0	6	7
248	R:R:I298	R:R:Y299	2.42	Yes	Yes	0	9	9
249	R:R:R302	R:R:R307	2.13	No	No	0	7	8
250	R:R:A88	R:R:G44	1.95	No	Yes	0	6	7
251	R:R:A77	R:R:G74	1.95	No	No	0	9	7
252	R:R:C175	R:R:P176	1.88	No	No	0	3	4
253	R:R:G30	R:R:S29	1.86	No	No	0	4	7
254	R:R:G44	R:R:S47	1.86	Yes	No	0	7	7
255	R:R:G148	R:R:T146	1.82	No	No	0	4	9
256	R:R:G74	R:R:I58	1.76	No	Yes	0	7	8
257	R:R:G171	R:R:M170	1.75	No	No	0	4	4
258	R:R:C40	R:R:V36	1.71	No	No	0	6	5
259	R:R:C40	R:R:V92	1.71	No	No	0	6	5
260	R:R:G44	R:R:L43	1.71	Yes	Yes	1	7	6
261	R:R:G44	R:R:L289	1.71	Yes	Yes	1	7	6
262	R:R:A48	R:R:S84	1.71	No	No	0	6	8
263	R:R:A79	R:R:S120	1.71	No	No	0	8	9
264	R:R:A104	R:R:S102	1.71	No	No	0	1	6
265	R:R:G204	R:R:L125	1.71	No	No	0	5	6
266	R:R:G155	R:R:L154	1.71	No	Yes	0	4	8
267	R:R:A221	R:R:S224	1.71	No	No	0	5	4
268	R:R:A270	R:R:T271	1.68	No	No	0	4	3
269	R:R:L167	R:R:P168	1.64	No	No	0	5	5
270	R:R:C257	R:R:I256	1.64	Yes	No	0	8	5
271	R:R:A162	R:R:M115	1.61	No	Yes	0	3	5
272	R:R:A216	R:R:L135	1.58	No	No	0	8	9
273	R:R:A266	R:R:L195	1.58	No	No	0	5	4
274	R:R:A244	R:R:L213	1.58	No	No	0	8	6
275	R:R:A216	R:R:L243	1.58	No	No	0	8	7
276	R:R:M26	R:R:V100	1.52	Yes	No	0	6	4
277	R:R:D275	R:R:S274	1.47	No	No	0	3	2
278	R:R:K103	R:R:M22	1.44	No	No	0	3	7
279	R:R:Q63	R:R:S61	1.44	No	No	0	6	7
280	R:R:F259	R:R:P260	1.44	No	No	0	5	9
281	R:R:E305	R:R:S308	1.44	Yes	No	0	6	4
282	R:R:I306	R:R:L301	1.43	Yes	No	0	8	6
283	R:R:P138	R:R:Y137	1.39	No	Yes	0	8	5
284	R:R:L45	R:R:L49	1.38	No	No	0	5	4
285	R:R:L254	R:R:L255	1.38	Yes	No	0	9	6
286	R:R:L223	R:R:Q227	1.33	No	No	0	6	2
287	R:R:F97	R:R:V96	1.31	No	No	0	3	4
288	R:R:H219	R:R:L223	1.29	No	No	0	7	6
289	R:R:M237	R:R:R238	1.24	No	No	0	4	4
290	R:R:H311	R:R:H312	1.19	No	No	0	4	5
291	R:R:K215	R:R:W214	1.16	Yes	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M26	3.9675	4	0	6
2	R:R:L28	7.3975	4	4	6
3	R:R:L43	4.6225	4	1	6
4	R:R:G44	1.8075	4	1	7
5	R:R:I58	3.37	4	0	8
6	R:R:L64	8.485	4	2	8
7	R:R:Y70	10.868	5	2	8
8	R:R:F72	6.9825	4	0	8
9	R:R:F81	5.1525	4	0	7
10	R:R:F87	8.41	4	1	6
11	R:R:F94	6.255	4	0	3
12	R:R:H95	7.075	4	0	4
13	R:R:F106	8.13	4	0	9
14	R:R:M115	5	4	0	5
15	R:R:T116	3.1225	4	0	7
16	R:R:F117	6.77	4	1	6
17	R:R:L126	5.6175	4	0	6
18	R:R:D130	5.9975	4	0	9
19	R:R:Y132	6.415	4	6	8
20	R:R:Y137	9.1625	4	0	5
21	R:R:L154	6.255	4	5	8
22	R:R:W158	5.2775	4	5	9
23	R:R:L182	5.01	4	0	4
24	R:R:F183	10.89	4	1	6
25	R:R:I186	3.76	4	1	5
26	R:R:Y190	5.7425	4	0	7
27	R:R:W194	5.725	6	1	5
28	R:R:F202	5.192	5	1	7
29	R:R:Y209	7.956	5	0	9
30	R:R:K215	4.6525	4	6	6
31	R:R:L239	3.06	4	0	5
32	R:R:L254	3.15	4	1	9
33	R:R:C257	3.595	4	7	8
34	R:R:W258	6.44	6	1	8
35	R:R:M265	5.21	4	0	6
36	R:R:L273	5.9325	4	0	1
37	R:R:F281	6.59286	7	1	4
38	R:R:M286	4.6725	4	0	5
39	R:R:L289	3.7425	4	1	6
40	R:R:I298	3.98	4	0	9
41	R:R:Y299	6.74333	6	1	9
42	R:R:E305	7.7025	4	2	6
43	R:R:I306	4.53	4	2	8
44	L:L:?1	8.70917	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F94	R:R:M26	16.8519	6.22	Yes	Yes	0	3	6
2	L:L:?1	R:R:F94	24.1141	3.45	Yes	Yes	0	0	3
3	R:R:H98	R:R:M26	11.9242	5.25	No	Yes	0	4	6
4	R:R:E181	R:R:L182	10.7919	5.3	No	Yes	0	4	4
5	R:R:F281	R:R:L182	26.9099	6.09	Yes	Yes	0	4	4
6	L:L:?1	R:R:F281	30.3418	10.36	Yes	Yes	1	0	4
7	R:R:H95	R:R:L28	10.6521	9	Yes	Yes	0	4	6
8	R:R:F91	R:R:H95	12.9797	12.44	No	Yes	0	6	4
9	R:R:F91	R:R:M286	14.6292	3.73	No	Yes	0	6	5
10	R:R:L289	R:R:M286	26.6862	4.24	Yes	Yes	0	6	5
11	R:R:F87	R:R:L289	44.5936	4.87	Yes	Yes	1	6	6
12	L:L:?1	R:R:F87	25.6588	15.54	Yes	Yes	1	0	6
13	R:R:C40	R:R:M286	12.4764	6.48	No	Yes	0	6	5
14	R:R:L289	R:R:L43	11.435	4.15	Yes	Yes	1	6	6
15	R:R:L43	R:R:M293	10.4145	8.48	Yes	No	0	6	6
16	R:R:G44	R:R:L289	11.7565	1.71	Yes	Yes	1	7	6
17	L:L:?1	R:R:F117	56.5318	4.32	Yes	Yes	1	0	6
18	R:R:F117	R:R:W258	74.0477	9.02	Yes	Yes	1	6	8
19	R:R:N291	R:R:W258	32.7742	6.78	No	Yes	0	9	8
20	R:R:N291	R:R:N295	16.2578	8.17	No	No	0	9	9
21	R:R:D80	R:R:N295	14.2937	9.42	No	No	0	9	9
22	R:R:D80	R:R:N51	10.4774	12.12	No	No	0	9	9
23	R:R:I58	R:R:I73	41.8746	2.94	Yes	No	0	8	8
24	R:R:I73	R:R:T127	43.5521	3.04	No	No	0	8	9
25	R:R:T127	R:R:Y299	38.0653	4.99	No	Yes	1	9	9
26	R:R:L124	R:R:Y299	92.7238	8.21	No	Yes	1	8	9
27	R:R:L124	R:R:L254	100	4.15	No	Yes	1	8	9
28	R:R:L254	R:R:W258	75.187	3.42	Yes	Yes	1	9	8
29	R:R:L64	R:R:S61	11.7355	9.01	Yes	No	0	8	7
30	R:R:I58	R:R:L64	31.7467	5.71	Yes	Yes	0	8	8
31	R:R:L64	R:R:Y70	13.4829	15.24	Yes	Yes	2	8	8
32	R:R:D130	R:R:F72	12.6162	3.58	Yes	Yes	0	9	8
33	R:R:F72	R:R:L126	20.4795	10.96	Yes	Yes	0	8	6
34	R:R:L126	R:R:M157	22.3247	4.24	Yes	No	0	6	6
35	R:R:M157	R:R:S161	24.7152	3.07	No	No	0	6	8
36	R:R:S161	R:R:T118	32.2779	3.2	No	No	0	8	6
37	R:R:T118	R:R:W194	40.1272	7.28	No	Yes	0	6	5
38	L:L:?1	R:R:W194	35.3114	5.65	Yes	Yes	1	0	5
39	R:R:F72	R:R:L71	16.6003	3.65	Yes	No	0	8	4
40	R:R:L151	R:R:L71	11.1903	4.15	No	No	0	1	4
41	R:R:L76	R:R:S123	23.2404	7.51	No	No	0	9	8
42	R:R:T116	R:R:V86	10.9806	3.17	Yes	No	0	7	4
43	R:R:V113	R:R:V86	13.3291	4.81	No	No	0	5	4
44	R:R:L108	R:R:V105	15.8035	2.98	No	No	0	4	4
45	R:R:L108	R:R:S112	26.0642	3	No	No	0	4	4
46	R:R:S112	R:R:Y166	28.5944	6.36	No	No	0	4	4
47	R:R:M115	R:R:Y166	33.585	10.78	Yes	No	0	5	4
48	R:R:M115	R:R:S165	35.9195	4.6	Yes	No	0	5	7
49	R:R:S165	R:R:T114	38.1002	7.99	No	No	0	7	4
50	L:L:?1	R:R:T114	22.3317	10.45	Yes	No	1	0	4
51	L:L:?1	R:R:I186	17.0336	3.04	Yes	Yes	1	0	5
52	R:R:W194	R:R:Y190	11.9172	4.82	Yes	Yes	0	5	7
53	R:R:I198	R:R:W194	31.7816	7.05	No	Yes	1	7	5
54	R:R:F202	R:R:I198	26.868	3.77	Yes	No	1	7	7
55	R:R:R131	R:R:Y299	62.6686	11.32	No	Yes	1	9	9
56	R:R:R131	R:R:Y209	68.5259	7.2	No	Yes	0	9	9
57	R:R:L247	R:R:Y209	61.3965	14.07	No	Yes	0	8	9
58	R:R:L247	R:R:V212	56.7834	2.98	No	No	0	8	9
59	R:R:L135	R:R:V212	55.2177	2.98	No	No	0	9	9
60	R:R:K215	R:R:L135	26.5814	2.82	Yes	No	0	6	9
61	R:R:K215	R:R:R136	13.441	8.66	Yes	No	6	6	6
62	R:R:R136	R:R:Y137	11.7355	26.75	No	Yes	0	6	5
63	R:R:I186	R:R:P187	15.8454	3.39	Yes	No	0	5	4
64	R:R:N188	R:R:S180	10.2258	5.96	No	No	0	4	4
65	R:R:L191	R:R:S180	12.749	3	No	No	0	5	4
66	R:R:L191	R:R:M265	15.6567	4.24	No	Yes	0	5	6
67	R:R:M265	R:R:W194	16.5374	3.49	Yes	Yes	0	6	5
68	R:R:L182	R:R:L273	15.426	4.15	Yes	Yes	0	4	1
69	R:R:L239	R:R:L243	26.5954	2.77	Yes	No	0	5	7
70	R:R:A216	R:R:L243	28.3777	1.58	No	No	0	8	7
71	R:R:A216	R:R:L135	30.1601	1.58	No	No	0	8	9
72	R:R:I298	R:R:Y299	15.4749	2.42	Yes	Yes	0	9	9
73	R:R:C257	R:R:N291	15.7196	6.3	Yes	No	0	8	9
74	R:R:F117	R:R:F87	18.9977	5.36	Yes	Yes	1	6	6
75	R:R:S123	R:R:S75	21.9962	3.26	No	No	0	8	9
76	R:R:L154	R:R:S75	16.5513	9.01	Yes	No	5	8	9
77	R:R:F72	R:R:L154	15.8035	9.74	Yes	Yes	0	8	8
78	R:R:L76	R:R:Y299	17.9632	4.69	No	Yes	1	9	9
79	R:R:F202	R:R:L254	25.8405	3.65	Yes	Yes	1	7	9
80	R:R:T114	R:R:W194	17.7535	6.06	No	Yes	1	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P184	R:R:Y25	18.08	0	No	No	5	4	1	2
R:R:F94	R:R:M26	6.22	0	Yes	Yes	3	6	1	2
R:R:V113	R:R:V86	4.81	1	No	No	5	4	1	2
R:R:F87	R:R:V113	7.87	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	5.36	1	Yes	Yes	6	6	1	1
R:R:F87	R:R:L289	4.87	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:F87	15.54	1	Yes	Yes	0	6	0	1
R:R:F106	R:R:F94	12.86	0	Yes	Yes	9	3	2	1
L:L:?1	R:R:F94	3.45	1	Yes	Yes	0	3	0	1
R:R:F106	R:R:I110	8.79	0	Yes	No	9	4	2	1
R:R:F106	R:R:P184	7.22	0	Yes	No	9	5	2	1
L:L:?1	R:R:I110	8.09	1	Yes	No	0	4	0	1
L:L:?1	R:R:V113	3.17	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	7.99	0	No	No	7	4	2	1
R:R:T114	R:R:W194	6.06	1	No	Yes	4	5	1	1
L:L:?1	R:R:T114	10.45	1	Yes	No	0	4	0	1
R:R:F117	R:R:W258	9.02	1	Yes	Yes	6	8	1	2
R:R:C288	R:R:F117	8.38	1	No	Yes	7	6	2	1
L:L:?1	R:R:F117	4.32	1	Yes	Yes	0	6	0	1
R:R:T118	R:R:W194	7.28	0	No	Yes	6	5	2	1
R:R:F281	R:R:L182	6.09	1	Yes	Yes	4	4	1	2
R:R:F183	R:R:I186	3.77	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:M265	7.46	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	6.43	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F183	25.9	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	8.15	1	Yes	No	0	5	0	1
R:R:I186	R:R:P187	3.39	1	Yes	No	5	4	1	2
R:R:I186	R:R:Y190	4.84	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:I186	3.04	1	Yes	Yes	0	5	0	1
R:R:W194	R:R:Y190	4.82	1	Yes	Yes	5	7	1	2
R:R:I198	R:R:W194	7.05	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	0	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	5.65	1	Yes	Yes	0	5	0	1
R:R:C288	R:R:W258	7.84	1	No	Yes	7	8	2	2
R:R:F281	R:R:V261	5.24	1	Yes	No	4	6	1	2
R:R:F281	R:R:L264	7.31	1	Yes	No	4	4	1	2
R:R:F281	R:R:S285	7.93	1	Yes	No	4	5	1	1
L:L:?1	R:R:F281	10.36	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S285	6.39	1	Yes	No	0	5	0	1
R:R:C284	R:R:F281	2.79	0	No	Yes	4	4	2	1
R:R:F94	R:R:M22	2.49	0	Yes	No	3	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	260
Number of Links	291
Number of Hubs	44
Number of Links mediated by Hubs	156
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	39145
Length Of Smallest Path	3
Average Path Length	12.0204
Length of Longest Path	29
Minimum Path Strength	1.31
Average Path Strength	5.8533
Maximum Path Strength	18.005
Minimum Path Correlation	0.7
Average Path Correlation	0.923415
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	51.4723
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.2593
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9GF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	9GF
Name	2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol
Synonyms
Identifier
Formula	C24 H40 O3
Molecular Weight	376.573
SMILES
PubChem	104895
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	3
Total Bonds	68
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUR_nogp_Chain_R M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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