psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M22	R:R:Y25	8.38	No	No	0	7	4
2	R:R:D24	R:R:Y25	9.2	No	No	0	4	4
3	R:R:P184	R:R:Y25	15.3	No	No	0	5	4
4	R:R:F94	R:R:M26	7.46	No	No	0	3	6
5	R:R:H98	R:R:M26	6.57	No	No	0	4	6
6	R:R:D275	R:R:I27	2.8	No	No	0	3	5
7	R:R:H98	R:R:L28	10.29	No	No	0	4	6
8	R:R:Q32	R:R:S29	4.33	Yes	No	0	5	7
9	R:R:G30	R:R:P31	4.06	No	No	0	4	4
10	R:R:Q32	R:R:V36	5.73	Yes	Yes	1	5	5
11	R:R:K279	R:R:Q32	14.92	No	Yes	1	2	5
12	R:R:F283	R:R:Q32	8.2	No	Yes	1	4	5
13	R:R:F91	R:R:V36	2.62	Yes	Yes	1	6	5
14	R:R:F283	R:R:V36	2.62	No	Yes	1	4	5
15	R:R:M286	R:R:V36	3.04	Yes	Yes	1	5	5
16	R:R:L39	R:R:L43	6.92	No	Yes	0	5	6
17	R:R:C40	R:R:F91	8.38	No	Yes	1	6	6
18	R:R:C40	R:R:M286	6.48	No	Yes	1	6	5
19	R:R:L289	R:R:L43	4.15	No	Yes	1	6	6
20	R:R:I290	R:R:L43	5.71	No	Yes	0	4	6
21	R:R:L45	R:R:L49	2.77	No	No	0	5	4
22	R:R:E50	R:R:L46	5.3	No	No	1	8	4
23	R:R:L46	R:R:M293	2.83	No	No	1	4	6
24	R:R:N51	R:R:S47	4.47	Yes	Yes	1	9	7
25	R:R:D80	R:R:S47	2.94	Yes	Yes	1	9	7
26	R:R:S47	R:R:S84	6.52	Yes	No	1	7	8
27	R:R:M293	R:R:S47	3.07	No	Yes	1	6	7
28	R:R:A48	R:R:F81	2.77	No	No	0	6	7
29	R:R:E50	R:R:M293	5.41	No	No	1	8	6
30	R:R:E50	R:R:V297	4.28	No	No	0	8	6
31	R:R:D80	R:R:N51	12.12	Yes	Yes	1	9	9
32	R:R:F81	R:R:N51	6.04	No	Yes	0	7	9
33	R:R:N51	R:R:P296	6.52	Yes	No	1	9	9
34	R:R:F81	R:R:V52	3.93	No	No	0	7	5
35	R:R:I58	R:R:V54	3.07	No	No	0	8	9
36	R:R:A77	R:R:L55	3.15	No	No	0	9	7
37	R:R:G78	R:R:L55	5.13	No	No	0	7	7
38	R:R:S60	R:R:Y56	6.36	No	No	0	5	5
39	R:R:L57	R:R:S309	4.5	No	No	0	8	7
40	R:R:A310	R:R:L57	3.15	No	No	0	6	8
41	R:R:C313	R:R:L57	3.17	No	No	0	6	8
42	R:R:I58	R:R:I73	2.94	No	No	0	8	8
43	R:R:L64	R:R:S61	7.51	Yes	No	0	8	7
44	R:R:Q63	R:R:R66	3.5	No	No	0	6	7
45	R:R:E305	R:R:Q63	3.82	No	No	0	6	6
46	R:R:L64	R:R:Y70	3.52	Yes	Yes	2	8	8
47	R:R:E305	R:R:L64	6.63	No	Yes	2	6	8
48	R:R:I306	R:R:L64	2.85	No	Yes	2	8	8
49	R:R:L64	R:R:S309	3	Yes	No	0	8	7
50	R:R:R147	R:R:R65	5.33	No	No	0	3	3
51	R:R:R147	R:R:R66	4.26	No	No	0	3	7
52	R:R:K67	R:R:Y70	5.97	No	Yes	0	6	8
53	R:R:L145	R:R:P68	3.28	Yes	No	0	6	5
54	R:R:D130	R:R:S69	7.36	Yes	No	0	9	8
55	R:R:I73	R:R:Y70	2.42	No	Yes	0	8	8
56	R:R:S303	R:R:Y70	8.9	No	Yes	2	8	8
57	R:R:E305	R:R:Y70	11.22	No	Yes	2	6	8
58	R:R:I306	R:R:Y70	6.04	No	Yes	2	8	8
59	R:R:L151	R:R:L71	2.77	No	No	0	1	4
60	R:R:F72	R:R:L126	3.65	Yes	No	0	8	6
61	R:R:D130	R:R:F72	5.97	Yes	Yes	0	9	8
62	R:R:A150	R:R:F72	2.77	No	Yes	0	7	8
63	R:R:F72	R:R:T153	2.59	Yes	No	0	8	6
64	R:R:S123	R:R:S75	3.26	No	No	0	8	9
65	R:R:L154	R:R:S75	9.01	No	No	4	8	9
66	R:R:S75	R:R:W158	6.18	No	Yes	4	9	9
67	R:R:L76	R:R:S123	7.51	No	No	0	9	8
68	R:R:L124	R:R:L76	4.15	No	No	0	8	9
69	R:R:L76	R:R:Y299	4.69	No	No	0	9	9
70	R:R:A79	R:R:W158	2.59	No	Yes	0	8	9
71	R:R:D80	R:R:S292	5.89	Yes	No	0	9	9
72	R:R:D80	R:R:P296	3.22	Yes	No	1	9	9
73	R:R:L82	R:R:V86	2.98	No	No	0	7	4
74	R:R:L82	R:R:T116	4.42	No	No	0	7	7
75	R:R:A83	R:R:T116	3.36	No	No	0	8	7
76	R:R:S112	R:R:V86	6.46	No	No	0	4	4
77	R:R:F87	R:R:S285	6.61	Yes	No	1	6	5
78	R:R:F87	R:R:M286	2.49	Yes	Yes	1	6	5
79	R:R:F87	R:R:L289	9.74	Yes	No	1	6	6
80	L:L:?1	R:R:F87	5.94	Yes	Yes	1	0	6
81	R:R:K109	R:R:S90	10.71	No	No	0	5	4
82	R:R:S90	R:R:V113	3.23	No	No	0	4	5
83	L:L:?1	R:R:S90	6.27	Yes	No	0	0	4
84	R:R:F91	R:R:H95	18.1	Yes	No	0	6	4
85	R:R:F91	R:R:M286	7.46	Yes	Yes	1	6	5
86	L:L:?1	R:R:F91	2.54	Yes	Yes	1	0	6
87	R:R:V92	R:R:V96	6.41	No	No	5	5	4
88	R:R:F97	R:R:V92	2.62	No	No	5	3	5
89	R:R:F94	R:R:H95	12.44	No	No	0	3	4
90	L:L:?1	R:R:F94	12.72	Yes	No	0	0	3
91	R:R:F97	R:R:V96	7.87	No	No	5	3	4
92	R:R:D101	R:R:V105	2.92	No	No	0	2	4
93	R:R:S102	R:R:V105	4.85	No	No	0	6	4
94	R:R:K103	R:R:T173	3	No	No	0	3	5
95	R:R:K103	R:R:L185	5.64	No	No	0	3	4
96	R:R:F106	R:R:K109	4.96	No	No	0	9	5
97	R:R:F106	R:R:I110	7.54	No	No	0	9	4
98	R:R:F106	R:R:P184	4.33	No	No	0	9	5
99	R:R:L108	R:R:L169	2.77	No	No	0	4	6
100	L:L:?1	R:R:I110	2.98	Yes	No	0	0	4
101	R:R:G111	R:R:T114	3.64	No	Yes	0	6	4
102	R:R:G111	R:R:Y166	2.9	No	Yes	0	6	4
103	R:R:S112	R:R:Y166	3.82	No	Yes	0	4	4
104	R:R:F117	R:R:V113	2.62	Yes	No	0	6	5
105	R:R:S165	R:R:T114	7.99	No	Yes	0	7	4
106	R:R:T114	R:R:W194	6.06	Yes	Yes	1	4	5
107	L:L:?1	R:R:T114	13.34	Yes	Yes	1	0	4
108	R:R:M115	R:R:S165	6.13	No	No	0	5	7
109	R:R:M115	R:R:Y166	4.79	No	Yes	0	5	4
110	R:R:F117	R:R:T116	3.89	Yes	No	0	6	7
111	R:R:F117	R:R:W258	5.01	Yes	Yes	1	6	8
112	R:R:C288	R:R:F117	4.19	No	Yes	1	7	6
113	R:R:S161	R:R:T118	6.4	No	No	0	8	6
114	R:R:T118	R:R:W194	7.28	No	Yes	0	6	5
115	R:R:A119	R:R:W158	6.48	No	Yes	0	7	9
116	R:R:A119	R:R:S161	3.42	No	No	0	7	8
117	R:R:I198	R:R:V121	4.61	No	Yes	1	7	8
118	R:R:L201	R:R:V121	5.96	No	Yes	0	7	8
119	R:R:F202	R:R:V121	5.24	Yes	Yes	1	7	8
120	R:R:V121	R:R:W258	2.45	Yes	Yes	1	8	8
121	R:R:G122	R:R:M157	5.24	No	No	0	5	6
122	R:R:L124	R:R:L254	4.15	No	Yes	0	8	9
123	R:R:I129	R:R:L125	4.28	No	No	0	6	6
124	R:R:I205	R:R:L125	2.85	Yes	No	0	8	6
125	R:R:L126	R:R:M157	8.48	No	No	0	6	6
126	R:R:R131	R:R:T127	6.47	No	No	0	9	9
127	R:R:A128	R:R:T208	3.36	No	No	0	9	6
128	R:R:A128	R:R:Y209	5.34	No	Yes	0	9	9
129	R:R:D130	R:R:Y141	9.2	Yes	No	3	9	7
130	R:R:D130	R:R:L145	6.79	Yes	Yes	3	9	6
131	R:R:R131	R:R:Y209	3.09	No	Yes	0	9	9
132	R:R:R136	R:R:Y132	12.35	No	Yes	0	6	8
133	R:R:T208	R:R:Y132	2.5	No	Yes	0	6	8
134	R:R:H211	R:R:Y132	3.27	No	Yes	0	5	8
135	R:R:V212	R:R:Y132	2.52	No	Yes	0	9	8
136	R:R:L133	R:R:L145	2.77	No	Yes	0	5	6
137	R:R:C134	R:R:L135	3.17	No	No	0	8	9
138	R:R:C134	R:R:Y141	5.38	No	No	0	8	7
139	R:R:L135	R:R:V212	4.47	No	No	0	9	9
140	R:R:R136	R:R:Y137	10.29	No	No	0	6	5
141	R:R:K215	R:R:R136	2.48	No	No	0	6	6
142	R:R:S140	R:R:Y137	2.54	No	No	0	5	5
143	R:R:P138	R:R:P139	5.84	No	No	0	8	7
144	R:R:L144	R:R:S140	3	No	No	0	4	5
145	R:R:L145	R:R:Y141	5.86	Yes	No	3	6	7
146	R:R:R149	R:R:T146	7.76	No	No	0	6	9
147	R:R:L154	R:R:W158	5.69	No	Yes	4	8	9
148	R:R:L160	R:R:V164	2.98	No	No	0	4	5
149	R:R:L167	R:R:P168	3.28	No	No	1	5	5
150	R:R:L167	R:R:W172	6.83	No	Yes	1	5	5
151	R:R:L167	R:R:Y190	5.86	No	Yes	1	5	7
152	R:R:P168	R:R:Y190	15.3	No	Yes	1	5	7
153	R:R:G171	R:R:W172	5.63	No	Yes	0	4	5
154	R:R:P187	R:R:W172	5.4	Yes	Yes	1	4	5
155	R:R:W172	R:R:Y190	3.86	Yes	Yes	1	5	7
156	R:R:C174	R:R:R177	2.79	No	No	0	5	3
157	R:R:C174	R:R:C179	7.28	No	No	0	5	9
158	R:R:D189	R:R:R177	5.96	No	No	0	4	3
159	R:R:L191	R:R:S180	3	No	No	0	5	4
160	R:R:S180	R:R:S268	4.89	No	No	0	4	3
161	R:R:E181	R:R:T272	11.29	No	No	0	4	1
162	R:R:E181	R:R:K278	12.15	No	No	0	4	2
163	R:R:F183	R:R:L182	13.4	Yes	Yes	1	6	4
164	R:R:L182	R:R:M265	2.83	Yes	Yes	1	4	6
165	R:R:L182	R:R:S268	9.01	Yes	No	0	4	3
166	R:R:F281	R:R:L182	18.27	Yes	Yes	1	4	4
167	R:R:F183	R:R:I186	2.51	Yes	Yes	1	6	5
168	R:R:F183	R:R:L191	3.65	Yes	No	0	6	5
169	R:R:F183	R:R:M265	4.98	Yes	Yes	1	6	6
170	R:R:F183	R:R:F281	5.36	Yes	Yes	1	6	4
171	L:L:?1	R:R:F183	21.2	Yes	Yes	1	0	6
172	L:L:?1	R:R:P184	4.57	Yes	No	0	0	5
173	R:R:I186	R:R:P187	3.39	Yes	Yes	1	5	4
174	L:L:?1	R:R:I186	3.98	Yes	Yes	1	0	5
175	R:R:P187	R:R:Y190	2.78	Yes	Yes	1	4	7
176	R:R:L269	R:R:N188	2.75	No	No	0	3	4
177	L:L:?1	R:R:Y190	4.9	Yes	Yes	1	0	7
178	R:R:L191	R:R:L269	4.15	No	No	0	5	3
179	R:R:L192	R:R:L196	4.15	No	No	0	4	3
180	R:R:L192	R:R:L269	4.15	No	No	0	4	3
181	R:R:I198	R:R:W194	5.87	No	Yes	1	7	5
182	R:R:M265	R:R:W194	3.49	Yes	Yes	1	6	5
183	L:L:?1	R:R:W194	13.48	Yes	Yes	1	0	5
184	R:R:L195	R:R:L262	4.15	No	No	0	4	6
185	R:R:F197	R:R:L201	8.53	No	No	0	5	7
186	R:R:F202	R:R:I198	3.77	Yes	No	1	7	7
187	R:R:F202	R:R:L254	7.31	Yes	Yes	1	7	9
188	R:R:F202	R:R:W258	15.03	Yes	Yes	1	7	8
189	R:R:F202	R:R:L262	2.44	Yes	No	0	7	6
190	R:R:I205	R:R:Y209	2.42	Yes	Yes	0	8	9
191	R:R:I205	R:R:L254	2.85	Yes	Yes	0	8	9
192	R:R:I206	R:R:L251	4.28	No	No	6	5	7
193	R:R:I206	R:R:L255	5.71	No	No	6	5	6
194	R:R:H211	R:R:Y207	17.42	No	No	0	5	4
195	R:R:L247	R:R:Y209	5.86	No	Yes	0	8	9
196	R:R:L213	R:R:L247	4.15	No	No	0	6	8
197	R:R:K215	R:R:Q218	4.07	No	No	0	6	5
198	R:R:D240	R:R:H217	8.82	No	No	0	7	5
199	R:R:R238	R:R:V220	6.54	No	Yes	7	4	5
200	R:R:L239	R:R:V220	2.98	No	Yes	0	5	5
201	R:R:D240	R:R:V220	5.84	No	Yes	7	7	5
202	R:R:H226	R:R:S222	2.79	No	No	0	4	3
203	R:R:L223	R:R:Q230	3.99	No	No	0	6	2
204	R:R:Q227	R:R:Q230	12.8	No	No	0	2	2
205	R:R:M234	R:R:Q230	6.8	No	No	0	2	2
206	R:R:P232	R:R:V231	3.53	No	No	0	1	3
207	R:R:D240	R:R:R238	10.72	No	No	7	7	4
208	R:R:R238	R:R:V241	7.85	No	No	0	4	5
209	R:R:K245	R:R:V241	3.04	No	No	0	7	5
210	R:R:L243	R:R:L247	5.54	No	No	0	7	8
211	R:R:R302	R:R:T246	15.52	No	No	0	7	8
212	R:R:L249	R:R:R302	4.86	No	No	0	6	7
213	R:R:I298	R:R:V250	4.61	No	No	0	9	8
214	R:R:V250	R:R:Y299	3.79	No	No	0	8	9
215	R:R:L251	R:R:L255	2.77	No	No	6	7	6
216	R:R:N291	R:R:V253	4.43	Yes	No	0	9	7
217	R:R:L254	R:R:W258	4.56	Yes	Yes	1	9	8
218	R:R:C257	R:R:L287	4.76	No	No	0	8	8
219	R:R:C257	R:R:N291	7.87	No	Yes	0	8	9
220	R:R:C288	R:R:W258	7.84	No	Yes	1	7	8
221	R:R:N291	R:R:W258	6.78	Yes	Yes	0	9	8
222	R:R:F259	R:R:P260	4.33	No	No	0	5	9
223	R:R:C284	R:R:P260	5.65	No	No	0	4	9
224	R:R:F281	R:R:V261	2.62	Yes	No	0	4	6
225	R:R:F281	R:R:L264	4.87	Yes	No	0	4	4
226	R:R:C284	R:R:L264	3.17	No	No	0	4	4
227	R:R:F281	R:R:M265	2.49	Yes	Yes	1	4	6
228	R:R:H267	R:R:T271	2.74	No	No	0	4	3
229	R:R:H267	R:R:L273	6.43	No	No	0	4	1
230	R:R:L273	R:R:V277	4.47	No	No	0	1	3
231	R:R:Q276	R:R:S274	2.89	No	No	0	3	2
232	R:R:D275	R:R:K278	4.15	No	No	0	3	2
233	R:R:K279	R:R:Q276	10.85	No	No	0	2	3
234	R:R:F283	R:R:K279	3.72	No	No	1	4	2
235	L:L:?1	R:R:F281	3.39	Yes	Yes	1	0	4
236	L:L:?1	R:R:S285	7.32	Yes	No	1	0	5
237	R:R:I290	R:R:L287	2.85	No	No	0	4	8
238	R:R:N291	R:R:N295	10.9	Yes	No	0	9	9
239	R:R:I298	R:R:V294	3.07	No	No	0	9	6
240	R:R:L301	R:R:R307	2.43	No	No	0	6	8
241	R:R:I306	R:R:S303	4.64	No	No	2	8	8
242	R:R:G304	R:R:R307	9.01	No	No	0	4	8
243	R:R:L108	R:R:Y166	2.34	No	Yes	0	4	4
244	R:R:H311	R:R:R307	2.26	No	No	0	4	8
245	R:R:Q218	R:R:W214	2.19	No	No	0	5	3
246	R:R:A77	R:R:G74	1.95	No	No	0	9	7
247	R:R:C174	R:R:P187	1.88	No	Yes	0	5	4
248	R:R:C175	R:R:P176	1.88	No	No	0	3	4
249	R:R:G44	R:R:S47	1.86	Yes	Yes	1	7	7
250	R:R:G44	R:R:S84	1.86	Yes	No	1	7	8
251	R:R:G204	R:R:T208	1.82	No	No	0	5	6
252	R:R:P296	R:R:V54	1.77	No	No	0	9	9
253	R:R:G74	R:R:I58	1.76	No	No	0	7	8
254	R:R:G171	R:R:M170	1.75	No	No	0	4	4
255	R:R:G30	R:R:K33	1.74	No	No	0	4	5
256	R:R:G44	R:R:L43	1.71	Yes	Yes	1	7	6
257	R:R:G44	R:R:L289	1.71	Yes	No	1	7	6
258	R:R:C89	R:R:V85	1.71	No	No	0	7	4
259	R:R:A104	R:R:S102	1.71	No	No	0	1	6
260	R:R:G148	R:R:L151	1.71	No	No	0	4	1
261	R:R:A37	R:R:V96	1.7	No	No	0	5	4
262	R:R:A300	R:R:V54	1.7	No	No	0	8	9
263	R:R:S224	R:R:V220	1.62	No	Yes	0	4	5
264	R:R:S224	R:R:V231	1.62	No	No	0	4	3
265	R:R:S274	R:R:V277	1.62	No	No	0	2	3
266	R:R:A162	R:R:M115	1.61	No	No	0	3	5
267	R:R:V85	R:R:V86	1.6	No	No	0	4	4
268	R:R:T41	R:R:V92	1.59	No	No	0	5	5
269	R:R:A216	R:R:L135	1.58	No	No	0	8	9
270	R:R:A266	R:R:L195	1.58	No	No	0	5	4
271	R:R:A244	R:R:L213	1.58	No	No	0	8	6
272	R:R:A216	R:R:L243	1.58	No	No	0	8	7
273	R:R:C89	R:R:N93	1.57	No	No	0	7	3
274	R:R:I27	R:R:S29	1.55	No	No	0	5	7
275	R:R:I156	R:R:V152	1.54	No	No	0	3	3
276	R:R:L124	R:R:S120	1.5	No	No	0	8	9
277	R:R:G148	R:R:R147	1.5	No	No	0	4	3
278	R:R:L301	R:R:V297	1.49	No	No	0	6	6
279	R:R:L107	R:R:T173	1.47	No	No	0	5	5
280	R:R:K142	R:R:K67	1.44	No	No	0	5	6
281	R:R:P178	R:R:R177	1.44	No	No	0	4	3
282	R:R:P232	R:R:R229	1.44	No	No	0	1	4
283	R:R:I186	R:R:L107	1.43	Yes	No	0	5	5
284	R:R:I205	R:R:L251	1.43	Yes	No	0	8	7
285	R:R:I298	R:R:L249	1.43	No	No	0	9	6
286	R:R:P138	R:R:Y137	1.39	No	No	0	8	5
287	R:R:D101	R:R:K109	1.38	No	No	0	2	5
288	R:R:F197	R:R:V164	1.31	No	No	0	5	5
289	R:R:R242	R:R:T246	1.29	No	No	0	8	8
290	R:R:L144	R:R:R149	1.21	No	No	0	4	6
291	R:R:D228	R:R:R229	1.19	No	No	0	3	4
292	R:R:H62	R:R:R66	1.13	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q32	8.295	4	1	5
2	R:R:V36	3.5025	4	1	5
3	R:R:L43	4.6225	4	1	6
4	R:R:G44	1.785	4	1	7
5	R:R:S47	3.772	5	1	7
6	R:R:N51	7.2875	4	1	9
7	R:R:L64	4.702	5	2	8
8	R:R:Y70	6.345	6	2	8
9	R:R:F72	3.745	4	0	8
10	R:R:D80	6.0425	4	1	9
11	R:R:F87	6.195	4	1	6
12	R:R:F91	7.82	5	1	6
13	R:R:T114	7.7575	4	1	4
14	R:R:F117	3.9275	4	1	6
15	R:R:V121	4.565	4	1	8
16	R:R:D130	7.33	4	3	9
17	R:R:Y132	5.16	4	0	8
18	R:R:L145	4.675	4	3	6
19	R:R:W158	5.235	4	4	9
20	R:R:Y166	3.4625	4	0	4
21	R:R:W172	5.43	4	1	5
22	R:R:L182	10.8775	4	1	4
23	R:R:F183	8.51667	6	1	6
24	R:R:I186	2.8275	4	1	5
25	R:R:P187	3.3625	4	1	4
26	R:R:Y190	6.54	5	1	7
27	R:R:W194	7.236	5	1	5
28	R:R:F202	6.758	5	1	7
29	R:R:I205	2.3875	4	0	8
30	R:R:Y209	4.1775	4	0	9
31	R:R:V220	4.245	4	7	5
32	R:R:L254	4.7175	4	1	9
33	R:R:W258	6.945	6	1	8
34	R:R:M265	3.4475	4	1	6
35	R:R:F281	6.16667	6	1	4
36	R:R:M286	4.8675	4	1	5
37	R:R:N291	7.495	4	0	9
38	L:L:?1	7.89462	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q32	R:R:V36	19.5152	5.73	Yes	Yes	1	5	5
2	R:R:F91	R:R:V36	21.6172	2.62	Yes	Yes	1	6	5
3	L:L:?1	R:R:F91	25.0026	2.54	Yes	Yes	1	0	6
4	R:R:K279	R:R:Q32	10.0137	14.92	No	Yes	1	2	5
5	R:R:F283	R:R:V36	11.1493	2.62	No	Yes	1	4	5
6	L:L:?1	R:R:F87	67.8039	5.94	Yes	Yes	1	0	6
7	R:R:F87	R:R:M286	12.6017	2.49	Yes	Yes	1	6	5
8	R:R:F87	R:R:L289	78.6733	9.74	Yes	No	1	6	6
9	R:R:I290	R:R:L43	28.9268	5.71	No	Yes	0	4	6
10	R:R:E50	R:R:M293	10.3887	5.41	No	No	1	8	6
11	R:R:M293	R:R:S47	13.8111	3.07	No	Yes	1	6	7
12	R:R:G44	R:R:S47	100	1.86	Yes	Yes	1	7	7
13	R:R:G44	R:R:L289	75.103	1.71	Yes	No	1	7	6
14	R:R:N51	R:R:S47	46.9156	4.47	Yes	Yes	1	9	7
15	R:R:D80	R:R:S47	44.053	2.94	Yes	Yes	1	9	7
16	R:R:N51	R:R:P296	41.8031	6.52	Yes	No	1	9	9
17	R:R:D80	R:R:P296	41.4968	3.22	Yes	No	1	9	9
18	R:R:I58	R:R:V54	75.0343	3.07	No	No	0	8	9
19	R:R:P296	R:R:V54	80.5588	1.77	No	No	0	9	9
20	R:R:G74	R:R:I58	12.0999	1.76	No	No	0	7	8
21	R:R:L64	R:R:S309	11.8939	3	Yes	No	0	8	7
22	R:R:L64	R:R:Y70	17.5452	3.52	Yes	Yes	2	8	8
23	R:R:I73	R:R:Y70	58.2075	2.42	No	Yes	0	8	8
24	R:R:I58	R:R:I73	61.0383	2.94	No	No	0	8	8
25	R:R:E305	R:R:Y70	26.4762	11.22	No	Yes	2	6	8
26	R:R:E305	R:R:Q63	24.0731	3.82	No	No	0	6	6
27	R:R:Q63	R:R:R66	21.1049	3.5	No	No	0	6	7
28	R:R:R147	R:R:R66	15.1262	4.26	No	No	0	3	7
29	R:R:C134	R:R:Y141	22.0978	5.38	No	No	0	8	7
30	R:R:C134	R:R:L135	23.8935	3.17	No	No	0	8	9
31	R:R:A216	R:R:L135	24.3689	1.58	No	No	0	8	9
32	R:R:A216	R:R:L243	25.9744	1.58	No	No	0	8	7
33	R:R:L243	R:R:L247	27.58	5.54	No	No	0	7	8
34	R:R:L247	R:R:Y209	32.777	5.86	No	Yes	0	8	9
35	R:R:I205	R:R:Y209	68.0839	2.42	Yes	Yes	0	8	9
36	R:R:I205	R:R:L254	76.9251	2.85	Yes	Yes	0	8	9
37	R:R:F202	R:R:L254	60.0137	7.31	Yes	Yes	1	7	9
38	R:R:F202	R:R:I198	64.1967	3.77	Yes	No	1	7	7
39	R:R:I198	R:R:W194	72.758	5.87	No	Yes	1	7	5
40	L:L:?1	R:R:W194	68.6015	13.48	Yes	Yes	1	0	5
41	R:R:D130	R:R:Y141	14.7935	9.2	Yes	No	3	9	7
42	R:R:D130	R:R:F72	11.2126	5.97	Yes	Yes	0	9	8
43	R:R:L124	R:R:L254	23.6611	4.15	No	Yes	0	8	9
44	R:R:L124	R:R:L76	20.1648	4.15	No	No	0	8	9
45	R:R:L76	R:R:Y299	15.0787	4.69	No	No	0	9	9
46	R:R:S90	R:R:V113	10.1141	3.23	No	No	0	4	5
47	L:L:?1	R:R:S90	12.9133	6.27	Yes	No	0	0	4
48	L:L:?1	R:R:T114	11.4133	13.34	Yes	Yes	1	0	4
49	R:R:G111	R:R:T114	10.2461	3.64	No	Yes	0	6	4
50	L:L:?1	R:R:I186	14.1967	3.98	Yes	Yes	1	0	5
51	R:R:A128	R:R:Y209	31.3193	5.34	No	Yes	0	9	9
52	R:R:A128	R:R:T208	29.7243	3.36	No	No	0	9	6
53	R:R:T208	R:R:Y132	26.5237	2.5	No	Yes	0	6	8
54	R:R:R136	R:R:Y132	20.4077	12.35	No	Yes	0	6	8
55	R:R:R136	R:R:Y137	13.0717	10.29	No	No	0	6	5
56	L:L:?1	R:R:Y190	16.098	4.9	Yes	Yes	1	0	7
57	R:R:C174	R:R:P187	13.8587	1.88	No	Yes	0	5	4
58	R:R:F183	R:R:L191	11.2443	3.65	Yes	No	0	6	5
59	L:L:?1	R:R:F183	11.2232	21.2	Yes	Yes	1	0	6
60	L:L:?1	R:R:F281	10.5102	3.39	Yes	Yes	1	0	4
61	R:R:V250	R:R:Y299	13.2302	3.79	No	No	0	8	9
62	R:R:I298	R:R:V250	11.3711	4.61	No	No	0	9	8
63	R:R:N291	R:R:W258	33.5376	6.78	Yes	Yes	0	9	8
64	R:R:C257	R:R:L287	27.9814	4.76	No	No	0	8	8
65	R:R:I290	R:R:L287	28.3934	2.85	No	No	0	4	8
66	R:R:C257	R:R:N291	28.7525	7.87	No	Yes	0	8	9
67	R:R:S274	R:R:V277	11.3816	1.62	No	No	0	2	3
68	R:R:Q276	R:R:S274	14.202	2.89	No	No	0	3	2
69	R:R:K279	R:R:Q276	17.0117	10.85	No	No	0	2	3
70	R:R:M286	R:R:V36	10.3201	3.04	Yes	Yes	1	5	5
71	R:R:G44	R:R:L43	27.2526	1.71	Yes	Yes	1	7	6
72	R:R:L254	R:R:W258	33.5692	4.56	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P184	R:R:Y25	15.3	0	No	No	5	4	1	2
R:R:F94	R:R:M26	7.46	0	No	No	3	6	1	2
R:R:F91	R:R:V36	2.62	1	Yes	Yes	6	5	1	2
R:R:M286	R:R:V36	3.04	1	Yes	Yes	5	5	2	2
R:R:C40	R:R:F91	8.38	1	No	Yes	6	6	2	1
R:R:C40	R:R:M286	6.48	1	No	Yes	6	5	2	2
R:R:F87	R:R:S285	6.61	1	Yes	No	6	5	1	1
R:R:F87	R:R:M286	2.49	1	Yes	Yes	6	5	1	2
R:R:F87	R:R:L289	9.74	1	Yes	No	6	6	1	2
L:L:?1	R:R:F87	5.94	1	Yes	Yes	0	6	0	1
R:R:K109	R:R:S90	10.71	0	No	No	5	4	2	1
R:R:S90	R:R:V113	3.23	0	No	No	4	5	1	2
L:L:?1	R:R:S90	6.27	1	Yes	No	0	4	0	1
R:R:F91	R:R:H95	18.1	1	Yes	No	6	4	1	2
R:R:F91	R:R:M286	7.46	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:F91	2.54	1	Yes	Yes	0	6	0	1
R:R:F94	R:R:H95	12.44	0	No	No	3	4	1	2
L:L:?1	R:R:F94	12.72	1	Yes	No	0	3	0	1
R:R:F106	R:R:K109	4.96	0	No	No	9	5	2	2
R:R:F106	R:R:I110	7.54	0	No	No	9	4	2	1
R:R:F106	R:R:P184	4.33	0	No	No	9	5	2	1
L:L:?1	R:R:I110	2.98	1	Yes	No	0	4	0	1
R:R:G111	R:R:T114	3.64	0	No	Yes	6	4	2	1
R:R:S165	R:R:T114	7.99	0	No	Yes	7	4	2	1
R:R:T114	R:R:W194	6.06	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:T114	13.34	1	Yes	Yes	0	4	0	1
R:R:T118	R:R:W194	7.28	0	No	Yes	6	5	2	1
R:R:L167	R:R:P168	3.28	1	No	No	5	5	2	2
R:R:L167	R:R:W172	6.83	1	No	Yes	5	5	2	2
R:R:L167	R:R:Y190	5.86	1	No	Yes	5	7	2	1
R:R:P168	R:R:Y190	15.3	1	No	Yes	5	7	2	1
R:R:P187	R:R:W172	5.4	1	Yes	Yes	4	5	2	2
R:R:W172	R:R:Y190	3.86	1	Yes	Yes	5	7	2	1
R:R:F183	R:R:L182	13.4	1	Yes	Yes	6	4	1	2
R:R:L182	R:R:M265	2.83	1	Yes	Yes	4	6	2	2
R:R:F281	R:R:L182	18.27	1	Yes	Yes	4	4	1	2
R:R:F183	R:R:I186	2.51	1	Yes	Yes	6	5	1	1
R:R:F183	R:R:L191	3.65	1	Yes	No	6	5	1	2
R:R:F183	R:R:M265	4.98	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	5.36	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F183	21.2	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	4.57	1	Yes	No	0	5	0	1
R:R:I186	R:R:P187	3.39	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:I186	3.98	1	Yes	Yes	0	5	0	1
R:R:P187	R:R:Y190	2.78	1	Yes	Yes	4	7	2	1
L:L:?1	R:R:Y190	4.9	1	Yes	Yes	0	7	0	1
R:R:I198	R:R:W194	5.87	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	3.49	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	13.48	1	Yes	Yes	0	5	0	1
R:R:F281	R:R:V261	2.62	1	Yes	No	4	6	1	2
R:R:F281	R:R:L264	4.87	1	Yes	No	4	4	1	2
R:R:F281	R:R:M265	2.49	1	Yes	Yes	4	6	1	2
L:L:?1	R:R:F281	3.39	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S285	7.32	1	Yes	No	0	5	0	1
R:R:I186	R:R:L107	1.43	1	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6PT0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	258
Number of Links	292
Number of Hubs	38
Number of Links mediated by Hubs	132
Number of Communities	7
Number of Nodes involved in Communities	60
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	41993
Length Of Smallest Path	3
Average Path Length	13.9709
Length of Longest Path	35
Minimum Path Strength	1.315
Average Path Strength	4.90135
Maximum Path Strength	17.3
Minimum Path Correlation	0.7
Average Path Correlation	0.933376
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.914
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9459
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • regulation of action potential • negative regulation of action potential • negative regulation of biological process • action potential • regulation of biological quality • regulation of membrane potential • immune response • immune system process • response to amine • response to chemical • response to nitrogen compound • response to amphetamine • defense response • response to stress • inflammatory response • multicellular organismal process • regulation of leukocyte activation • cell activation • regulation of cell activation • myeloid leukocyte activation • leukocyte activation • negative regulation of cell activation • negative regulation of mast cell activation • negative regulation of immune system process • negative regulation of cellular process • mast cell activation • regulation of mast cell activation • regulation of immune system process • regulation of multicellular organismal process • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • cell chemotaxis • chemotaxis • response to external stimulus • leukocyte migration • cellular response to chemical stimulus • taxis • cell migration • cell motility • leukocyte chemotaxis • locomotion • trans-synaptic signaling • regulation of signaling • trans-synaptic signaling, modulating synaptic transmission • modulation of chemical synaptic transmission • trans-synaptic signaling by endocannabinoid • cell-cell signaling • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • trans-synaptic signaling by lipid, modulating synaptic transmission • anterograde trans-synaptic signaling • trans-synaptic signaling by lipid • regulation of cell communication • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • negative regulation of synaptic transmission, GABAergic • negative regulation of signaling • negative regulation of synaptic transmission • negative regulation of cell communication • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell body • perikaryon • neuronal cell body
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell body • perikaryon • neuronal cell body • extrinsic component of plasma membrane • cytoplasmic side of plasma membrane • cytoplasmic side of membrane • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • side of membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • intracellular organelle • organelle • endoplasmic reticulum • intracellular membrane-bounded organelle • endomembrane system • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • catalytic complex • plasma membrane protein complex • membrane protein complex • heterotrimeric G-protein complex • GTPase complex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Galpha insert domain-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Galpha insert domain-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WI5
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WI5
Name	WIN 55212-2
Synonyms	WIN 55212-2 (2,3-Dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl)methanone monomethanesulfonate WIN 55212-2 mesylate
Identifier
Formula	C27 H26 N2 O3
Molecular Weight	426.507
SMILES
PubChem	5311501
Formal Charge	0
Total Atoms	58
Total Chiral Atoms	1
Total Bonds	63
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>6PT0_nogp_Chain_R M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q D R Q V P G M A R M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	To be published
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	To be published
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-	Gi1/β1/γ2	2.84	2023-05-10	10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55,940	-		2.84	2023-05-10	10.1038/s41467-023-37112-9
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	10.1038/s41467-023-37112-9
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	-	3.2	2020-02-12	10.1016/j.cell.2020.01.008
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	10.1016/j.cell.2020.01.007
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-	Gi1/β1/γ2	2.9	2020-02-12	10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	PubChem 145915889	-		2.9	2020-02-12	10.1016/j.cell.2020.01.008
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	10.1016/j.cell.2018.12.011

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