psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M22	R:R:P21	6.71	Yes	No	0	7	4
2	R:R:M22	R:R:Y25	4.79	Yes	No	1	7	4
3	R:R:F94	R:R:M22	4.98	Yes	Yes	1	3	7
4	R:R:M22	R:R:P184	5.03	Yes	Yes	1	7	5
5	R:R:L185	R:R:M22	4.24	No	Yes	0	4	7
6	R:R:E181	R:R:Y25	13.47	No	No	0	4	4
7	R:R:P184	R:R:Y25	11.13	Yes	No	1	5	4
8	R:R:F94	R:R:M26	4.98	Yes	No	0	3	6
9	R:R:I27	R:R:K278	13.09	No	No	0	5	2
10	R:R:H95	R:R:L28	5.14	Yes	Yes	0	4	6
11	R:R:F283	R:R:L28	3.65	No	Yes	0	4	6
12	R:R:G30	R:R:S29	3.71	No	No	5	4	7
13	R:R:K33	R:R:S29	6.12	Yes	No	5	5	7
14	R:R:G30	R:R:P31	4.06	No	No	0	4	4
15	R:R:G30	R:R:K33	5.23	No	Yes	5	4	5
16	R:R:Q32	R:R:V36	4.3	No	No	0	5	5
17	R:R:F283	R:R:Q32	14.05	No	No	0	4	5
18	R:R:K33	R:R:V96	4.55	Yes	No	0	5	4
19	R:R:H98	R:R:K33	10.48	No	Yes	0	4	5
20	R:R:A37	R:R:V96	5.09	No	No	0	5	4
21	R:R:L289	R:R:L43	5.54	No	Yes	0	6	6
22	R:R:L43	R:R:M293	4.24	Yes	No	0	6	6
23	R:R:L46	R:R:M293	4.24	No	No	0	4	6
24	R:R:N51	R:R:S47	4.47	No	No	0	9	7
25	R:R:S47	R:R:S84	6.52	No	No	0	7	8
26	R:R:A48	R:R:F81	4.16	No	Yes	0	6	7
27	R:R:E50	R:R:M293	5.41	No	No	0	8	6
28	R:R:E50	R:R:P296	11	No	Yes	0	8	9
29	R:R:D80	R:R:N51	6.73	Yes	No	0	9	9
30	R:R:N51	R:R:P296	4.89	No	Yes	0	9	9
31	R:R:F81	R:R:V52	3.93	Yes	No	0	7	5
32	R:R:S60	R:R:Y56	13.99	No	No	0	5	5
33	R:R:L64	R:R:S61	7.51	Yes	No	0	8	7
34	R:R:H62	R:R:R65	7.9	No	Yes	3	5	3
35	R:R:H62	R:R:R66	9.03	No	No	3	5	7
36	R:R:L64	R:R:Q63	3.99	Yes	No	0	8	6
37	R:R:L64	R:R:Y70	5.86	Yes	Yes	2	8	8
38	R:R:E305	R:R:L64	5.3	Yes	Yes	2	6	8
39	R:R:R65	R:R:R66	9.6	Yes	No	3	3	7
40	R:R:R147	R:R:R65	8.53	No	Yes	3	3	3
41	R:R:R147	R:R:R66	4.26	No	No	3	3	7
42	R:R:K67	R:R:P68	3.35	No	No	0	6	5
43	R:R:K67	R:R:Y70	10.75	No	Yes	0	6	8
44	R:R:L145	R:R:P68	6.57	No	No	0	6	5
45	R:R:D130	R:R:S69	10.31	Yes	No	0	9	8
46	R:R:S303	R:R:Y70	7.63	No	Yes	2	8	8
47	R:R:E305	R:R:Y70	12.35	Yes	Yes	2	6	8
48	R:R:I306	R:R:Y70	4.84	No	Yes	2	8	8
49	R:R:F72	R:R:L71	3.65	Yes	No	6	8	4
50	R:R:A150	R:R:L71	4.73	No	No	6	7	4
51	R:R:L151	R:R:L71	4.15	No	No	0	1	4
52	R:R:F72	R:R:L126	7.31	Yes	No	0	8	6
53	R:R:D130	R:R:F72	3.58	Yes	Yes	0	9	8
54	R:R:A150	R:R:F72	4.16	No	Yes	6	7	8
55	R:R:F72	R:R:L154	3.65	Yes	Yes	0	8	8
56	R:R:S123	R:R:S75	4.89	No	No	0	8	9
57	R:R:L154	R:R:S75	9.01	Yes	No	0	8	9
58	R:R:D80	R:R:L76	8.14	Yes	No	0	9	9
59	R:R:L76	R:R:S123	6.01	No	No	0	9	8
60	R:R:L124	R:R:L76	4.15	No	No	0	8	9
61	R:R:D80	R:R:S292	5.89	Yes	No	0	9	9
62	R:R:D80	R:R:N295	9.42	Yes	No	0	9	9
63	R:R:F81	R:R:V85	5.24	Yes	No	0	7	4
64	R:R:A83	R:R:T116	5.03	No	No	0	8	7
65	R:R:A83	R:R:F117	4.16	No	No	0	8	6
66	R:R:F87	R:R:F91	5.36	Yes	No	1	6	6
67	R:R:F87	R:R:V113	5.24	Yes	No	1	6	5
68	R:R:F117	R:R:F87	7.5	No	Yes	0	6	6
69	R:R:F87	R:R:S285	5.28	Yes	No	1	6	5
70	R:R:F87	R:R:L289	7.31	Yes	No	0	6	6
71	L:L:?1	R:R:F87	10.98	Yes	Yes	1	0	6
72	R:R:K109	R:R:S90	4.59	No	No	0	5	4
73	R:R:F91	R:R:H95	10.18	No	Yes	1	6	4
74	L:L:?1	R:R:F91	5.86	Yes	No	1	0	6
75	R:R:V92	R:R:V96	4.81	No	No	0	5	4
76	R:R:F94	R:R:H95	7.92	Yes	Yes	1	3	4
77	R:R:D101	R:R:F94	4.78	No	Yes	0	2	3
78	L:L:?1	R:R:F94	10.98	Yes	Yes	1	0	3
79	L:L:?1	R:R:H95	3.86	Yes	Yes	1	0	4
80	R:R:D101	R:R:F106	8.36	No	Yes	0	2	9
81	R:R:D101	R:R:K109	9.68	No	No	0	2	5
82	R:R:K103	R:R:L107	5.64	No	No	0	3	5
83	R:R:K103	R:R:T173	4.5	No	No	0	3	5
84	R:R:F106	R:R:I110	10.05	Yes	No	1	9	4
85	R:R:F106	R:R:P184	7.22	Yes	Yes	1	9	5
86	R:R:F106	R:R:L185	7.31	Yes	No	0	9	4
87	L:L:?1	R:R:F106	4.39	Yes	Yes	1	0	9
88	R:R:L107	R:R:L185	4.15	No	No	0	5	4
89	L:L:?1	R:R:I110	6	Yes	No	1	0	4
90	R:R:G111	R:R:T114	3.64	No	Yes	0	6	4
91	L:L:?1	R:R:V113	6.27	Yes	No	1	0	5
92	R:R:S165	R:R:T114	4.8	No	Yes	1	7	4
93	R:R:T114	R:R:Y190	3.75	Yes	Yes	1	4	7
94	L:L:?1	R:R:T114	4.43	Yes	Yes	1	0	4
95	R:R:M115	R:R:T116	4.52	Yes	No	0	5	7
96	R:R:M115	R:R:W158	3.49	Yes	Yes	0	5	9
97	R:R:M115	R:R:S165	4.6	Yes	No	1	5	7
98	R:R:M115	R:R:Y166	9.58	Yes	Yes	1	5	4
99	R:R:F117	R:R:W258	8.02	No	Yes	0	6	8
100	R:R:T118	R:R:W194	6.06	No	Yes	1	6	5
101	R:R:I198	R:R:T118	6.08	No	No	1	7	6
102	R:R:A119	R:R:W158	7.78	No	Yes	0	7	9
103	R:R:A119	R:R:S161	3.42	No	No	0	7	8
104	R:R:F202	R:R:V121	6.55	Yes	No	0	7	8
105	R:R:G122	R:R:M157	5.24	No	No	0	5	6
106	R:R:L124	R:R:Y299	8.21	No	Yes	0	8	9
107	R:R:L125	R:R:L201	4.15	No	Yes	0	6	7
108	R:R:I205	R:R:L125	5.71	No	No	0	8	6
109	R:R:L126	R:R:T153	4.42	No	No	0	6	6
110	R:R:L126	R:R:M157	4.24	No	No	0	6	6
111	R:R:T127	R:R:Y299	8.74	No	Yes	0	9	9
112	R:R:A128	R:R:T208	5.03	No	No	0	9	6
113	R:R:A128	R:R:Y209	6.67	No	Yes	0	9	9
114	R:R:D130	R:R:Y141	12.64	Yes	No	0	9	7
115	R:R:D130	R:R:L145	5.43	Yes	No	0	9	6
116	R:R:R131	R:R:Y209	6.17	No	Yes	4	9	9
117	R:R:R131	R:R:Y299	13.38	No	Yes	4	9	9
118	R:R:R136	R:R:Y132	11.32	No	No	0	6	8
119	R:R:H211	R:R:Y132	20.69	No	No	0	5	8
120	R:R:V212	R:R:Y132	3.79	No	No	0	9	8
121	R:R:C134	R:R:Y141	9.41	No	No	0	8	7
122	R:R:K215	R:R:L135	4.23	No	No	0	6	9
123	R:R:R136	R:R:Y137	20.58	No	No	0	6	5
124	R:R:K215	R:R:R136	4.95	No	No	0	6	6
125	R:R:L144	R:R:Y137	5.86	No	No	0	4	5
126	R:R:P138	R:R:P139	7.79	No	No	0	8	7
127	R:R:L144	R:R:S140	6.01	No	No	0	4	5
128	R:R:K142	R:R:Y141	9.55	No	No	0	5	7
129	R:R:L145	R:R:R149	3.64	No	No	0	6	6
130	R:R:R149	R:R:T146	5.17	No	No	0	6	9
131	R:R:I156	R:R:T153	6.08	No	No	0	3	6
132	R:R:L154	R:R:W158	5.69	Yes	Yes	0	8	9
133	R:R:M157	R:R:W158	4.65	No	Yes	0	6	9
134	R:R:F197	R:R:L160	3.65	No	No	0	5	4
135	R:R:F197	R:R:V164	7.87	No	No	0	5	5
136	R:R:S165	R:R:Y166	5.09	No	Yes	1	7	4
137	R:R:L167	R:R:W172	4.56	No	Yes	0	5	5
138	R:R:P168	R:R:W172	4.05	No	Yes	1	5	5
139	R:R:I186	R:R:P168	3.39	Yes	No	1	5	5
140	R:R:P168	R:R:Y190	15.3	No	Yes	1	5	7
141	R:R:P187	R:R:W172	10.81	Yes	Yes	0	4	5
142	R:R:D189	R:R:W172	3.35	No	Yes	0	4	5
143	R:R:W172	R:R:Y190	13.5	Yes	Yes	1	5	7
144	R:R:C174	R:R:C179	7.28	No	No	0	5	9
145	R:R:C174	R:R:P187	3.77	No	Yes	0	5	4
146	R:R:C175	R:R:R177	5.57	No	No	0	3	3
147	R:R:N188	R:R:S180	4.47	No	No	0	4	4
148	R:R:E181	R:R:L273	5.3	No	No	0	4	1
149	R:R:E181	R:R:K278	5.4	No	No	0	4	2
150	R:R:L182	R:R:S268	9.01	No	No	0	4	3
151	R:R:F281	R:R:L182	9.74	Yes	No	0	4	4
152	R:R:F183	R:R:I186	3.77	Yes	Yes	1	6	5
153	R:R:F183	R:R:M265	4.98	Yes	Yes	0	6	6
154	R:R:F183	R:R:F281	5.36	Yes	Yes	1	6	4
155	L:L:?1	R:R:F183	27.82	Yes	Yes	1	0	6
156	L:L:?1	R:R:P184	7.9	Yes	Yes	1	0	5
157	R:R:I186	R:R:P187	3.39	Yes	Yes	0	5	4
158	R:R:I186	R:R:Y190	9.67	Yes	Yes	1	5	7
159	L:L:?1	R:R:Y190	3.52	Yes	Yes	1	0	7
160	R:R:L191	R:R:L269	4.15	No	No	0	5	3
161	R:R:L192	R:R:L269	5.54	No	No	0	4	3
162	R:R:I198	R:R:W194	16.44	No	Yes	1	7	5
163	R:R:M265	R:R:W194	4.65	Yes	Yes	0	6	5
164	L:L:?1	R:R:W194	19.85	Yes	Yes	1	0	5
165	R:R:L195	R:R:M265	5.65	No	Yes	0	4	6
166	R:R:F197	R:R:L201	6.09	No	Yes	0	5	7
167	R:R:F202	R:R:I198	6.28	Yes	No	0	7	7
168	R:R:F202	R:R:L254	4.87	Yes	No	0	7	9
169	R:R:F202	R:R:W258	8.02	Yes	Yes	0	7	8
170	R:R:L247	R:R:Y209	12.89	No	Yes	0	8	9
171	R:R:V250	R:R:Y209	3.79	No	Yes	4	8	9
172	R:R:L251	R:R:Y209	10.55	No	Yes	0	7	9
173	R:R:Y209	R:R:Y299	4.96	Yes	Yes	4	9	9
174	R:R:L213	R:R:L247	4.15	No	No	0	6	8
175	R:R:Q218	R:R:W214	5.48	No	No	0	5	3
176	R:R:D240	R:R:H217	6.3	Yes	No	0	7	5
177	R:R:D240	R:R:V220	16.07	Yes	No	0	7	5
178	R:R:L223	R:R:Q227	3.99	No	No	0	6	2
179	R:R:D240	R:R:M237	5.54	Yes	No	0	7	4
180	R:R:L239	R:R:L243	4.15	No	No	0	5	7
181	R:R:R302	R:R:T246	11.64	No	No	0	7	8
182	R:R:L249	R:R:R302	4.86	No	No	0	6	7
183	R:R:V250	R:R:Y299	8.83	No	Yes	4	8	9
184	R:R:I298	R:R:V253	4.61	No	No	0	9	7
185	R:R:F259	R:R:L255	3.65	No	No	0	5	6
186	R:R:C257	R:R:N291	7.87	No	Yes	0	8	9
187	R:R:C288	R:R:W258	7.84	No	Yes	0	7	8
188	R:R:N291	R:R:W258	5.65	Yes	Yes	0	9	8
189	R:R:C284	R:R:P260	3.77	No	No	0	4	9
190	R:R:F281	R:R:V261	3.93	Yes	No	0	4	6
191	R:R:F281	R:R:L264	4.87	Yes	No	0	4	4
192	R:R:D275	R:R:V277	13.15	No	No	0	3	3
193	R:R:K279	R:R:Q276	12.2	No	No	0	2	3
194	R:R:F283	R:R:K279	6.2	No	No	0	4	2
195	L:L:?1	R:R:F281	11.71	Yes	Yes	1	0	4
196	R:R:C288	R:R:S285	3.44	No	No	0	7	5
197	L:L:?1	R:R:S285	9.93	Yes	No	1	0	5
198	R:R:N291	R:R:V294	4.43	Yes	No	0	9	6
199	R:R:N291	R:R:N295	9.54	Yes	No	0	9	9
200	R:R:I298	R:R:V294	4.61	No	No	0	9	6
201	R:R:L301	R:R:V297	4.47	No	No	0	6	6
202	R:R:I306	R:R:S303	4.64	No	No	2	8	8
203	R:R:G304	R:R:R307	4.5	No	No	0	4	8
204	R:R:H312	R:R:S308	4.18	No	No	0	5	4
205	R:R:H211	R:R:Y207	3.27	No	No	0	5	4
206	R:R:A300	R:R:I306	3.25	No	No	0	8	8
207	R:R:C40	R:R:M286	3.24	No	No	0	6	5
208	R:R:S112	R:R:V86	3.23	No	No	0	4	4
209	R:R:S120	R:R:V121	3.23	No	No	0	9	8
210	R:R:C313	R:R:L57	3.17	No	No	0	6	8
211	R:R:C284	R:R:L264	3.17	No	No	0	4	4
212	R:R:C284	R:R:L287	3.17	No	No	0	4	8
213	R:R:A310	R:R:L57	3.15	No	No	0	6	8
214	R:R:I73	R:R:S69	3.1	No	No	0	8	8
215	R:R:I58	R:R:V54	3.07	No	No	0	8	9
216	R:R:K109	R:R:V105	3.04	No	No	0	5	4
217	R:R:I129	R:R:T208	3.04	No	No	0	6	6
218	R:R:M237	R:R:V241	3.04	No	No	0	4	5
219	R:R:L57	R:R:S309	3	No	No	0	8	7
220	R:R:L191	R:R:S180	3	No	No	0	5	4
221	R:R:L191	R:R:S268	3	No	No	0	5	3
222	R:R:L201	R:R:V121	2.98	Yes	No	0	7	8
223	R:R:L247	R:R:V212	2.98	No	No	0	8	9
224	R:R:L82	R:R:T116	2.95	No	No	0	7	7
225	R:R:F259	R:R:P260	2.89	No	No	0	5	9
226	R:R:P178	R:R:R177	2.88	No	No	0	4	3
227	R:R:P187	R:R:R177	2.88	Yes	No	0	4	3
228	R:R:I290	R:R:L43	2.85	No	Yes	0	4	6
229	R:R:I129	R:R:L133	2.85	No	No	0	6	5
230	R:R:I206	R:R:L251	2.85	No	No	0	5	7
231	R:R:L39	R:R:M286	2.83	No	No	0	5	5
232	R:R:L262	R:R:M265	2.83	No	Yes	0	6	6
233	R:R:K33	R:R:L28	2.82	Yes	Yes	0	5	6
234	R:R:L39	R:R:L43	2.77	No	Yes	0	5	6
235	R:R:L135	R:R:L243	2.77	No	No	7	9	7
236	R:R:L192	R:R:L196	2.77	No	No	0	4	3
237	R:R:A162	R:R:Y166	2.67	No	Yes	0	3	4
238	R:R:R65	R:R:S61	2.64	Yes	No	0	3	7
239	R:R:F97	R:R:V92	2.62	No	No	0	3	5
240	R:R:H316	R:R:K319	2.62	No	No	0	5	2
241	R:R:A79	R:R:W158	2.59	No	Yes	0	8	9
242	R:R:H219	R:R:L239	2.57	No	No	0	7	5
243	R:R:F81	R:R:L82	2.44	Yes	No	0	7	7
244	R:R:F200	R:R:L201	2.44	No	Yes	0	4	7
245	R:R:F97	R:R:N93	2.42	No	No	0	3	3
246	R:R:L108	R:R:Y166	2.34	No	Yes	0	4	4
247	R:R:H311	R:R:R307	2.26	No	No	0	4	8
248	R:R:R238	R:R:R242	2.13	No	No	0	4	8
249	R:R:H211	R:R:W214	2.12	No	No	0	5	3
250	R:R:A88	R:R:G44	1.95	No	No	0	6	7
251	R:R:A77	R:R:G74	1.95	No	No	0	9	7
252	R:R:A77	R:R:G78	1.95	No	No	0	9	7
253	R:R:C175	R:R:P176	1.88	No	No	0	3	4
254	R:R:G44	R:R:S84	1.86	No	No	0	7	8
255	R:R:G204	R:R:S203	1.86	No	No	0	5	3
256	R:R:G225	R:R:S224	1.86	No	No	0	4	4
257	R:R:G148	R:R:T146	1.82	No	No	0	4	9
258	R:R:G204	R:R:T208	1.82	No	No	0	5	6
259	R:R:P296	R:R:V54	1.77	Yes	No	0	9	9
260	R:R:P296	R:R:V297	1.77	Yes	No	0	9	6
261	R:R:G74	R:R:I58	1.76	No	No	0	7	8
262	R:R:P31	R:R:T34	1.75	No	No	0	4	4
263	R:R:G171	R:R:M170	1.75	No	No	0	4	4
264	R:R:G74	R:R:L55	1.71	No	No	0	7	7
265	R:R:G155	R:R:L154	1.71	No	Yes	0	4	8
266	R:R:A221	R:R:S224	1.71	No	No	0	5	4
267	R:R:G99	R:R:N93	1.7	No	No	0	5	3
268	R:R:A35	R:R:T34	1.68	No	No	0	5	4
269	R:R:C257	R:R:I256	1.64	No	No	0	8	5
270	R:R:E305	R:R:G304	1.64	Yes	No	0	6	4
271	R:R:S309	R:R:S61	1.63	No	No	0	7	7
272	R:R:S90	R:R:V86	1.62	No	No	0	4	4
273	R:R:S102	R:R:V105	1.62	No	No	0	6	4
274	R:R:S112	R:R:V113	1.62	No	No	0	4	5
275	R:R:S274	R:R:T272	1.6	No	No	0	2	1
276	R:R:T41	R:R:V38	1.59	No	No	0	5	5
277	R:R:T41	R:R:V92	1.59	No	No	0	5	5
278	R:R:A282	R:R:L28	1.58	No	Yes	0	4	6
279	R:R:A216	R:R:L135	1.58	No	No	7	8	9
280	R:R:A244	R:R:L213	1.58	No	No	0	8	6
281	R:R:A216	R:R:L243	1.58	No	No	7	8	7
282	R:R:A216	R:R:D240	1.54	No	Yes	0	8	7
283	R:R:L42	R:R:T41	1.47	No	No	0	4	5
284	R:R:E305	R:R:S308	1.44	Yes	No	0	6	4
285	R:R:L169	R:R:M170	1.41	No	No	0	6	4
286	R:R:P138	R:R:Y137	1.39	No	No	0	8	5
287	R:R:D24	R:R:K23	1.38	No	No	0	4	4
288	R:R:L46	R:R:L49	1.38	No	No	0	4	4
289	R:R:L55	R:R:L59	1.38	No	No	0	7	4
290	R:R:L107	R:R:L169	1.38	No	No	0	5	6
291	R:R:L108	R:R:L169	1.38	No	No	0	4	6
292	R:R:L163	R:R:L167	1.38	No	No	0	3	5
293	R:R:H267	R:R:T271	1.37	No	No	0	4	3
294	R:R:R149	R:R:V152	1.31	No	No	0	6	3
295	R:R:R238	R:R:V241	1.31	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M22	5.15	5	1	7
2	R:R:L28	3.2975	4	0	6
3	R:R:K33	5.84	5	5	5
4	R:R:L43	3.85	4	0	6
5	R:R:L64	5.665	4	2	8
6	R:R:R65	7.1675	4	3	3
7	R:R:Y70	8.286	5	2	8
8	R:R:F72	4.47	5	6	8
9	R:R:D80	7.545	4	0	9
10	R:R:F81	3.9425	4	0	7
11	R:R:F87	6.945	6	1	6
12	R:R:F94	6.728	5	1	3
13	R:R:H95	6.775	4	1	4
14	R:R:F106	7.466	5	1	9
15	R:R:T114	4.155	4	1	4
16	R:R:M115	5.5475	4	1	5
17	R:R:D130	7.99	4	0	9
18	R:R:L154	5.015	4	0	8
19	R:R:W158	4.84	5	0	9
20	R:R:Y166	4.92	4	1	4
21	R:R:W172	7.254	5	1	5
22	R:R:F183	10.4825	4	1	6
23	R:R:P184	7.82	4	1	5
24	R:R:I186	5.055	4	1	5
25	R:R:P187	5.2125	4	0	4
26	R:R:Y190	9.148	5	1	7
27	R:R:W194	11.75	4	1	5
28	R:R:L201	3.915	4	0	7
29	R:R:F202	6.43	4	0	7
30	R:R:Y209	7.505	6	4	9
31	R:R:D240	7.3625	4	0	7
32	R:R:W258	7.3825	4	0	8
33	R:R:M265	4.5275	4	0	6
34	R:R:F281	7.122	5	1	4
35	R:R:N291	6.8725	4	0	9
36	R:R:P296	4.8575	4	0	9
37	R:R:Y299	8.824	5	4	9
38	R:R:E305	5.1825	4	2	6
39	L:L:?1	9.53571	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H95	R:R:L28	62.3176	5.14	Yes	Yes	0	4	6
2	R:R:F283	R:R:L28	14.1285	3.65	No	Yes	0	4	6
3	R:R:G30	R:R:K33	11.3015	5.23	No	Yes	5	4	5
4	R:R:K33	R:R:L28	44.0789	2.82	Yes	Yes	0	5	6
5	R:R:K33	R:R:V96	25.2019	4.55	Yes	No	0	5	4
6	R:R:F87	R:R:L289	30.0547	7.31	Yes	No	0	6	6
7	L:L:?1	R:R:F87	61.4317	10.98	Yes	Yes	1	0	6
8	L:L:?1	R:R:F94	15.5615	10.98	Yes	Yes	1	0	3
9	L:L:?1	R:R:P184	15.6527	7.9	Yes	Yes	1	0	5
10	R:R:L289	R:R:L43	28.4132	5.54	No	Yes	0	6	6
11	R:R:L43	R:R:M293	21.6389	4.24	Yes	No	0	6	6
12	R:R:F117	R:R:F87	58.6113	7.5	No	Yes	0	6	6
13	R:R:F117	R:R:W258	57.1261	8.02	No	Yes	0	6	8
14	R:R:N291	R:R:W258	93.851	5.65	Yes	Yes	0	9	8
15	R:R:N291	R:R:N295	86.816	9.54	Yes	No	0	9	9
16	R:R:D80	R:R:N295	85.7478	9.42	Yes	No	0	9	9
17	R:R:D80	R:R:N51	24.9218	6.73	Yes	No	0	9	9
18	L:L:?1	R:R:S285	38.1384	9.93	Yes	No	1	0	5
19	R:R:C288	R:R:S285	37.741	3.44	No	No	0	7	5
20	R:R:C288	R:R:W258	37.4349	7.84	No	Yes	0	7	8
21	R:R:E50	R:R:M293	19.9583	5.41	No	No	0	8	6
22	R:R:E50	R:R:P296	19.6456	11	No	Yes	0	8	9
23	R:R:N51	R:R:P296	17.8218	4.89	No	Yes	0	9	9
24	R:R:N51	R:R:S47	13.464	4.47	No	No	0	9	7
25	R:R:S47	R:R:S84	10.1159	6.52	No	No	0	7	8
26	R:R:L82	R:R:T116	11.9789	2.95	No	No	0	7	7
27	R:R:A83	R:R:T116	14.9427	5.03	No	No	0	8	7
28	R:R:A83	R:R:F117	16.0565	4.16	No	No	0	8	6
29	R:R:M115	R:R:T116	16.3887	4.52	Yes	No	0	5	7
30	R:R:M115	R:R:S165	48.7103	4.6	Yes	No	1	5	7
31	R:R:S165	R:R:T114	51.9411	4.8	No	Yes	1	7	4
32	L:L:?1	R:R:T114	37.7866	4.43	Yes	Yes	1	0	4
33	R:R:L64	R:R:Y70	18.3299	5.86	Yes	Yes	2	8	8
34	R:R:K67	R:R:Y70	34.1714	10.75	No	Yes	0	6	8
35	R:R:K67	R:R:P68	35.6826	3.35	No	No	0	6	5
36	R:R:L145	R:R:P68	37.1678	6.57	No	No	0	6	5
37	R:R:D130	R:R:L145	44.4893	5.43	Yes	No	0	9	6
38	R:R:D130	R:R:F72	52.6772	3.58	Yes	Yes	0	9	8
39	R:R:F72	R:R:L154	58.2335	3.65	Yes	Yes	0	8	8
40	R:R:L154	R:R:W158	56.2272	5.69	Yes	Yes	0	8	9
41	R:R:M115	R:R:W158	62.3306	3.49	Yes	Yes	0	5	9
42	R:R:L64	R:R:S61	15.4377	7.51	Yes	No	0	8	7
43	R:R:L154	R:R:S75	36.3275	9.01	Yes	No	0	8	9
44	R:R:S123	R:R:S75	35.7608	4.89	No	No	0	8	9
45	R:R:D80	R:R:L76	86.6141	8.14	Yes	No	0	9	9
46	R:R:L124	R:R:L76	100	4.15	No	No	0	8	9
47	R:R:F91	R:R:H95	14.5909	10.18	No	Yes	1	6	4
48	R:R:D101	R:R:K109	14.1675	9.68	No	No	0	2	5
49	R:R:V92	R:R:V96	19.6912	4.81	No	No	0	5	4
50	L:L:?1	R:R:Y190	30.7322	3.52	Yes	Yes	1	0	7
51	L:L:?1	R:R:W194	14.63	19.85	Yes	Yes	1	0	5
52	R:R:I198	R:R:W194	11.777	16.44	No	Yes	1	7	5
53	R:R:F202	R:R:I198	11.7118	6.28	Yes	No	0	7	7
54	R:R:F202	R:R:V121	16.3887	6.55	Yes	No	0	7	8
55	R:R:L124	R:R:Y299	97.8439	8.21	No	Yes	0	8	9
56	R:R:L201	R:R:V121	12.8322	2.98	Yes	No	0	7	8
57	R:R:A128	R:R:Y209	15.7439	6.67	No	Yes	0	9	9
58	R:R:Y209	R:R:Y299	88.9265	4.96	Yes	Yes	4	9	9
59	R:R:A128	R:R:T208	13.1514	5.03	No	No	0	9	6
60	R:R:L247	R:R:Y209	69.4828	12.89	No	Yes	0	8	9
61	R:R:L247	R:R:V212	62.513	2.98	No	No	0	8	9
62	R:R:V212	R:R:Y132	60.1746	3.79	No	No	0	9	8
63	R:R:R136	R:R:Y132	48.2543	11.32	No	No	0	6	8
64	R:R:H211	R:R:Y132	10.5459	20.69	No	No	0	5	8
65	R:R:K215	R:R:R136	33.5135	4.95	No	No	0	6	6
66	R:R:K215	R:R:L135	30.9927	4.23	No	No	0	6	9
67	R:R:R136	R:R:Y137	13.1514	20.58	No	No	0	6	5
68	R:R:W172	R:R:Y190	24.3486	13.5	Yes	Yes	1	5	7
69	R:R:F183	R:R:I186	13.6139	3.77	Yes	Yes	1	6	5
70	L:L:?1	R:R:F183	16.1998	27.82	Yes	Yes	1	0	6
71	R:R:I186	R:R:Y190	17.2942	9.67	Yes	Yes	1	5	7
72	R:R:I186	R:R:P187	26.6871	3.39	Yes	Yes	0	5	4
73	R:R:P187	R:R:W172	15.327	10.81	Yes	Yes	0	4	5
74	R:R:C174	R:R:P187	12.1222	3.77	No	Yes	0	5	4
75	R:R:C175	R:R:R177	12.1222	5.57	No	No	0	3	3
76	R:R:P187	R:R:R177	23.7428	2.88	Yes	No	0	4	3
77	L:L:?1	R:R:F281	30.7973	11.71	Yes	Yes	1	0	4
78	R:R:F281	R:R:L182	16.5646	9.74	Yes	No	0	4	4
79	R:R:L182	R:R:S268	14.5388	9.01	No	No	0	4	3
80	R:R:L191	R:R:S268	12.5	3	No	No	0	5	3
81	R:R:A216	R:R:D240	18.3233	1.54	No	Yes	0	8	7
82	R:R:A216	R:R:L135	20.7269	1.58	No	No	7	8	9
83	R:R:D240	R:R:M237	10.5459	5.54	Yes	No	0	7	4
84	R:R:C284	R:R:L264	10.4482	3.17	No	No	0	4	4
85	R:R:F281	R:R:L264	12.5	4.87	Yes	No	0	4	4
86	R:R:I58	R:R:V54	11.7965	3.07	No	No	0	8	9
87	R:R:P296	R:R:V54	13.7181	1.77	Yes	No	0	9	9
88	L:L:?1	R:R:H95	46.8734	3.86	Yes	Yes	1	0	4
89	R:R:P184	R:R:Y25	10.2527	11.13	Yes	No	1	5	4
90	L:L:?1	R:R:F106	17.6459	4.39	Yes	Yes	1	0	9
91	R:R:F87	R:R:F91	15.0925	5.36	Yes	No	1	6	6
92	R:R:L76	R:R:S123	35.3309	6.01	No	No	0	9	8
93	R:R:F202	R:R:W258	13.2686	8.02	Yes	Yes	0	7	8
94	R:R:T114	R:R:Y190	14.8906	3.75	Yes	Yes	1	4	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M22	R:R:Y25	4.79	1	Yes	No	7	4	2	2
R:R:F94	R:R:M22	4.98	1	Yes	Yes	3	7	1	2
R:R:M22	R:R:P184	5.03	1	Yes	Yes	7	5	2	1
R:R:L185	R:R:M22	4.24	0	No	Yes	4	7	2	2
R:R:P184	R:R:Y25	11.13	1	Yes	No	5	4	1	2
R:R:F94	R:R:M26	4.98	1	Yes	No	3	6	1	2
R:R:H95	R:R:L28	5.14	1	Yes	Yes	4	6	1	2
R:R:F87	R:R:F91	5.36	1	Yes	No	6	6	1	1
R:R:F87	R:R:V113	5.24	1	Yes	No	6	5	1	1
R:R:F117	R:R:F87	7.5	0	No	Yes	6	6	2	1
R:R:F87	R:R:S285	5.28	1	Yes	No	6	5	1	1
R:R:F87	R:R:L289	7.31	1	Yes	No	6	6	1	2
L:L:?1	R:R:F87	10.98	1	Yes	Yes	0	6	0	1
R:R:F91	R:R:H95	10.18	1	No	Yes	6	4	1	1
L:L:?1	R:R:F91	5.86	1	Yes	No	0	6	0	1
R:R:F94	R:R:H95	7.92	1	Yes	Yes	3	4	1	1
R:R:D101	R:R:F94	4.78	0	No	Yes	2	3	2	1
L:L:?1	R:R:F94	10.98	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H95	3.86	1	Yes	Yes	0	4	0	1
R:R:D101	R:R:F106	8.36	0	No	Yes	2	9	2	1
R:R:F106	R:R:I110	10.05	1	Yes	No	9	4	1	1
R:R:F106	R:R:P184	7.22	1	Yes	Yes	9	5	1	1
R:R:F106	R:R:L185	7.31	1	Yes	No	9	4	1	2
L:L:?1	R:R:F106	4.39	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I110	6	1	Yes	No	0	4	0	1
R:R:G111	R:R:T114	3.64	0	No	Yes	6	4	2	1
L:L:?1	R:R:V113	6.27	1	Yes	No	0	5	0	1
R:R:S165	R:R:T114	4.8	1	No	Yes	7	4	2	1
R:R:T114	R:R:Y190	3.75	1	Yes	Yes	4	7	1	1
L:L:?1	R:R:T114	4.43	1	Yes	Yes	0	4	0	1
R:R:T118	R:R:W194	6.06	1	No	Yes	6	5	2	1
R:R:I198	R:R:T118	6.08	1	No	No	7	6	2	2
R:R:P168	R:R:W172	4.05	1	No	Yes	5	5	2	2
R:R:I186	R:R:P168	3.39	1	Yes	No	5	5	2	2
R:R:P168	R:R:Y190	15.3	1	No	Yes	5	7	2	1
R:R:W172	R:R:Y190	13.5	1	Yes	Yes	5	7	2	1
R:R:F281	R:R:L182	9.74	1	Yes	No	4	4	1	2
R:R:F183	R:R:I186	3.77	1	Yes	Yes	6	5	1	2
R:R:F183	R:R:M265	4.98	1	Yes	Yes	6	6	1	2
R:R:F183	R:R:F281	5.36	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:F183	27.82	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:P184	7.9	1	Yes	Yes	0	5	0	1
R:R:I186	R:R:Y190	9.67	1	Yes	Yes	5	7	2	1
L:L:?1	R:R:Y190	3.52	1	Yes	Yes	0	7	0	1
R:R:I198	R:R:W194	16.44	1	No	Yes	7	5	2	1
R:R:M265	R:R:W194	4.65	0	Yes	Yes	6	5	2	1
L:L:?1	R:R:W194	19.85	1	Yes	Yes	0	5	0	1
R:R:F281	R:R:V261	3.93	1	Yes	No	4	6	1	2
R:R:F281	R:R:L264	4.87	1	Yes	No	4	4	1	2
L:L:?1	R:R:F281	11.71	1	Yes	Yes	0	4	0	1
R:R:C288	R:R:S285	3.44	0	No	No	7	5	2	1
L:L:?1	R:R:S285	9.93	1	Yes	No	0	5	0	1
R:R:S112	R:R:V113	1.62	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GUS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	268
Number of Links	295
Number of Hubs	39
Number of Links mediated by Hubs	145
Number of Communities	7
Number of Nodes involved in Communities	47
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	45789
Length Of Smallest Path	3
Average Path Length	13.244
Length of Longest Path	31
Minimum Path Strength	1.38
Average Path Strength	6.28002
Maximum Path Strength	21.37
Minimum Path Correlation	0.7
Average Path Correlation	0.92925
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	52.346
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.5203
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KO3
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KO3
Name	Onternabez
Synonyms	Onternabez [(1S,2S,5S)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl]methanol
Identifier
Formula	C27 H42 O3
Molecular Weight	414.621
SMILES
PubChem	11553430
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	3
Total Bonds	74
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34972
Sequence	>8GUS_nogp_Chain_R P M K D Y M I L S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S H Q L R R K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V F H G V D S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y P P S Y K A L L T R G R A L V T L G I M W V L S A L V S Y L P L M G W T C C P R P C S E L F P L I P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G H Q M R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T T L S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E I R S S A H H C L A H W K K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6PT0	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-	Gi1/β1/γ2	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	6PT0 (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	WIN 55212-2	-		3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.007
	8GUQ	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-	Gi1/β1/γ2	3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUQ (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	Olorinab	-		3.08	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-	Gi1/β1/γ2	2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUR (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	CP55940	-		2.84	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-	Gi1/β1/γ2	2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUS (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	HU-308	-		2.97	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8X3L	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-	Gi1/β1/γ2	3.13	2024-11-20	doi.org/10.1073/pnas.2401091121
	8X3L (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	XWD	-		3.13	2024-11-20	doi.org/10.1073/pnas.2401091121

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