psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P22	R:R:Q24	7.9	No	No	0	2	6
2	R:R:Q24	R:R:W23	12.05	No	No	0	6	4
3	R:R:T32	R:R:T83	7.85	Yes	No	0	6	8
4	R:R:T32	R:R:W405	7.28	Yes	Yes	0	6	8
5	R:R:G33	R:R:S36	3.71	No	No	0	5	7
6	R:R:L35	R:R:W405	3.42	No	Yes	0	7	8
7	R:R:N80	R:R:S36	7.45	No	No	0	9	7
8	R:R:N43	R:R:T39	4.39	Yes	No	0	9	8
9	R:R:G75	R:R:T39	5.46	No	No	0	8	8
10	R:R:T39	R:R:T412	6.28	No	No	0	8	8
11	R:R:D71	R:R:N43	6.73	Yes	Yes	0	9	9
12	R:R:N43	R:R:P415	8.15	Yes	No	0	9	9
13	R:R:F429	R:R:L45	7.31	No	No	0	9	8
14	R:R:L432	R:R:L45	4.15	No	No	0	8	8
15	R:R:F425	R:R:S49	6.61	Yes	No	0	9	9
16	R:R:F50	R:R:K57	4.96	No	No	0	8	7
17	R:R:F50	R:R:Y62	5.16	No	No	0	8	7
18	R:R:F50	R:R:L65	9.74	No	No	0	8	7
19	R:R:V52	R:R:W437	8.58	No	Yes	0	7	3
20	R:R:E55	R:R:N53	10.52	No	Yes	0	7	8
21	R:R:L56	R:R:N53	9.61	No	Yes	0	9	8
22	R:R:N53	R:R:T428	5.85	Yes	No	3	8	8
23	R:R:N53	R:R:W437	9.04	Yes	Yes	3	8	3
24	R:R:E55	R:R:T54	4.23	No	No	0	7	7
25	R:R:K439	R:R:T54	7.51	No	No	0	5	7
26	R:R:E55	R:R:W442	4.36	No	No	0	7	4
27	R:R:F425	R:R:L56	6.09	Yes	No	0	9	9
28	R:R:V59	R:R:Y62	3.79	Yes	No	0	7	7
29	R:R:R137	R:R:V59	6.54	Yes	Yes	0	8	7
30	R:R:P139	R:R:V59	3.53	No	Yes	0	5	7
31	R:R:N60	R:R:R137	9.64	No	Yes	0	8	8
32	R:R:L64	R:R:N61	5.49	No	No	0	9	9
33	R:R:F425	R:R:N61	12.08	Yes	No	0	9	9
34	R:R:F63	R:R:L118	6.09	No	No	0	8	7
35	R:R:D122	R:R:F63	13.14	No	No	0	9	8
36	R:R:F63	R:R:I146	6.28	No	No	0	8	9
37	R:R:N115	R:R:S66	4.47	No	No	0	8	9
38	R:R:I146	R:R:S66	7.74	No	No	0	9	9
39	R:R:L116	R:R:L67	5.54	Yes	No	1	8	9
40	R:R:L67	R:R:N414	10.98	No	No	1	9	9
41	R:R:L67	R:R:Y418	3.52	No	Yes	1	9	9
42	R:R:D71	R:R:S411	7.36	Yes	No	0	9	9
43	R:R:D71	R:R:N414	8.08	Yes	No	0	9	9
44	R:R:F77	R:R:I73	3.77	No	No	5	6	8
45	R:R:I73	R:R:L104	4.28	No	No	5	8	6
46	R:R:A108	R:R:I73	4.87	No	No	0	7	8
47	R:R:I74	R:R:S109	4.64	No	No	0	8	8
48	R:R:I74	R:R:S411	9.29	No	No	0	8	9
49	R:R:F77	R:R:T76	3.89	No	No	0	6	5
50	R:R:F77	R:R:L104	3.65	No	No	5	6	6
51	R:R:D105	R:R:S78	10.31	No	No	1	9	8
52	R:R:S78	R:R:Y408	3.82	No	Yes	1	8	8
53	R:R:M79	R:R:W405	8.14	No	Yes	1	8	8
54	R:R:M79	R:R:Y408	11.97	No	Yes	1	8	8
55	R:R:L81	R:R:W101	7.97	No	Yes	0	7	7
56	R:R:L86	R:R:Y82	9.38	No	Yes	0	7	7
57	R:R:W101	R:R:Y82	3.86	Yes	Yes	0	7	7
58	R:R:Y404	R:R:Y82	11.91	Yes	Yes	1	7	7
59	R:R:W405	R:R:Y82	4.82	Yes	Yes	1	8	7
60	R:R:Y408	R:R:Y82	6.95	Yes	Yes	1	8	7
61	R:R:L87	R:R:T83	7.37	No	No	0	6	8
62	R:R:L86	R:R:Y85	3.52	No	Yes	0	7	7
63	R:R:W91	R:R:Y85	8.68	Yes	Yes	2	9	7
64	R:R:C178	R:R:Y85	4.03	No	Yes	2	9	7
65	R:R:E401	R:R:L86	9.28	No	No	0	6	7
66	R:R:L93	R:R:W91	4.56	No	Yes	0	7	9
67	R:R:C98	R:R:W91	6.53	No	Yes	2	9	9
68	R:R:W101	R:R:W91	4.69	Yes	Yes	0	7	9
69	R:R:C178	R:R:W91	11.75	No	Yes	2	9	9
70	R:R:R171	R:R:T95	9.06	Yes	No	0	7	4
71	R:R:C98	R:R:D99	4.67	No	No	2	9	7
72	R:R:C178	R:R:C98	7.28	No	No	2	9	9
73	R:R:D99	R:R:Q165	6.53	No	No	2	7	7
74	R:R:D99	R:R:R171	10.72	No	Yes	2	7	7
75	R:R:L102	R:R:W101	7.97	No	Yes	0	7	7
76	R:R:D105	R:R:Y408	9.2	No	Yes	1	9	8
77	L:L:?1	R:R:D105	9.68	Yes	No	1	0	9
78	R:R:W157	R:R:Y106	16.4	Yes	Yes	1	8	8
79	R:R:I161	R:R:Y106	3.63	Yes	Yes	1	7	8
80	R:R:I180	R:R:Y106	7.25	Yes	Yes	1	7	8
81	R:R:Y106	R:R:Y381	7.94	Yes	Yes	1	8	8
82	R:R:Y106	R:R:Y404	6.95	Yes	Yes	1	8	7
83	L:L:?1	R:R:Y106	13.38	Yes	Yes	1	0	8
84	R:R:S153	R:R:V107	4.85	No	No	0	8	8
85	R:R:S109	R:R:W378	3.71	No	Yes	1	8	8
86	L:L:?1	R:R:S109	11.78	Yes	No	1	0	8
87	R:R:M114	R:R:Q110	5.44	No	Yes	0	7	8
88	R:R:Q110	R:R:S153	5.78	Yes	No	0	8	8
89	R:R:Q110	R:R:W157	8.76	Yes	Yes	1	8	8
90	R:R:A196	R:R:Q110	4.55	No	Yes	0	8	8
91	L:L:?1	R:R:Q110	10.44	Yes	Yes	1	0	8
92	R:R:A111	R:R:W150	7.78	No	No	0	8	9
93	R:R:A111	R:R:S153	3.42	No	No	0	8	8
94	R:R:F374	R:R:V113	3.93	Yes	No	1	9	9
95	R:R:V113	R:R:W378	4.9	No	Yes	1	9	8
96	L:L:?1	R:R:V113	5.31	Yes	No	1	0	9
97	R:R:N115	R:R:W150	6.78	No	No	0	8	9
98	R:R:L116	R:R:M204	4.24	Yes	No	1	8	9
99	R:R:F374	R:R:L116	4.87	Yes	Yes	1	9	8
100	R:R:L116	R:R:N414	5.49	Yes	No	1	8	9
101	R:R:L116	R:R:Y418	4.69	Yes	Yes	1	8	9
102	R:R:F121	R:R:L117	3.65	No	No	0	7	7
103	R:R:I119	R:R:R123	5.01	No	No	1	9	9
104	R:R:I119	R:R:Y418	3.63	No	Yes	1	9	9
105	R:R:M204	R:R:S120	4.6	No	No	0	9	9
106	R:R:L207	R:R:S120	4.5	No	No	0	8	9
107	R:R:S120	R:R:Y208	3.82	No	Yes	0	9	9
108	R:R:F121	R:R:L207	8.53	No	No	0	7	8
109	R:R:D122	R:R:Y133	9.2	No	Yes	4	9	9
110	R:R:D122	R:R:R137	9.53	No	Yes	4	9	8
111	R:R:R123	R:R:Y208	6.17	No	Yes	1	9	9
112	R:R:R123	R:R:Y418	9.26	No	Yes	1	9	9
113	R:R:T128	R:R:Y124	16.23	No	No	0	8	8
114	R:R:L207	R:R:Y124	15.24	No	No	0	8	8
115	R:R:R210	R:R:Y124	7.2	No	No	0	7	8
116	R:R:F125	R:R:Y133	11.35	No	Yes	0	7	9
117	R:R:R129	R:R:S132	6.59	No	No	0	7	7
118	R:R:K136	R:R:S132	6.12	No	No	0	6	7
119	R:R:R137	R:R:Y133	19.55	Yes	Yes	4	8	9
120	R:R:P139	R:R:T138	3.5	No	No	0	5	8
121	R:R:R141	R:R:T138	6.47	No	No	0	8	8
122	R:R:L144	R:R:R140	7.29	No	No	0	2	6
123	R:R:A158	R:R:F154	4.16	No	No	0	6	6
124	R:R:I161	R:R:W157	3.52	Yes	Yes	1	7	8
125	R:R:T192	R:R:W157	4.85	No	Yes	0	8	8
126	L:L:?1	R:R:W157	7.31	Yes	Yes	1	0	8
127	R:R:I161	R:R:I180	5.89	Yes	Yes	1	7	7
128	R:R:F163	R:R:L162	3.65	No	No	0	6	6
129	R:R:V168	R:R:W164	6.13	Yes	Yes	0	4	7
130	R:R:Q181	R:R:W164	12.05	No	Yes	0	8	7
131	R:R:F182	R:R:W164	11.02	Yes	Yes	0	6	7
132	R:R:Q185	R:R:W164	8.76	No	Yes	0	7	7
133	R:R:Q165	R:R:Y166	6.76	No	No	0	7	5
134	R:R:Q165	R:R:R171	7.01	No	Yes	2	7	7
135	R:R:E170	R:R:V168	8.56	No	Yes	0	4	4
136	R:R:E170	R:R:T172	11.29	No	No	6	4	4
137	R:R:E170	R:R:Q181	7.65	No	No	6	4	8
138	R:R:R171	R:R:V173	6.54	Yes	No	0	7	4
139	R:R:Q181	R:R:T172	4.25	No	No	6	8	4
140	R:R:V173	R:R:Y179	10.09	No	No	0	4	4
141	R:R:F182	R:R:I180	5.02	Yes	Yes	0	6	7
142	R:R:I180	R:R:L183	7.14	Yes	No	0	7	7
143	R:R:F182	R:R:I188	5.02	Yes	No	0	6	8
144	R:R:T189	R:R:T389	4.71	No	No	0	7	8
145	R:R:F190	R:R:M194	4.98	No	No	0	7	6
146	R:R:F190	R:R:L386	4.87	No	No	0	7	7
147	R:R:G191	R:R:M194	3.49	No	No	0	6	6
148	R:R:M194	R:R:Y198	5.99	No	Yes	0	6	7
149	R:R:F197	R:R:Y198	11.35	Yes	Yes	1	9	7
150	R:R:F197	R:R:V201	7.87	Yes	No	0	9	7
151	R:R:F197	R:R:W378	6.01	Yes	Yes	1	9	8
152	R:R:F197	R:R:T379	3.89	Yes	Yes	0	9	7
153	R:R:F197	R:R:N382	25.37	Yes	No	1	9	8
154	L:L:?1	R:R:F197	5.21	Yes	Yes	1	0	9
155	R:R:N382	R:R:Y198	3.49	No	Yes	1	8	7
156	R:R:L386	R:R:Y198	3.52	No	Yes	0	7	7
157	R:R:F374	R:R:V201	3.93	Yes	No	0	9	7
158	R:R:F374	R:R:M204	7.46	Yes	No	1	9	9
159	R:R:C205	R:R:L371	6.35	No	No	0	5	7
160	R:R:L367	R:R:Y208	7.03	No	Yes	0	9	9
161	R:R:I370	R:R:Y208	7.25	Yes	Yes	1	8	9
162	R:R:L371	R:R:Y208	10.55	No	Yes	0	7	9
163	R:R:Y208	R:R:Y418	4.96	Yes	Yes	1	9	9
164	R:R:R213	R:R:W209	7	No	No	0	5	4
165	R:R:E216	R:R:Y212	13.47	No	Yes	0	7	7
166	R:R:A364	R:R:Y212	6.67	No	Yes	0	8	7
167	R:R:L367	R:R:Y212	3.52	No	Yes	0	9	7
168	R:R:E216	R:R:T215	4.23	No	No	0	7	8
169	R:R:E216	R:R:K361	10.8	No	No	0	7	7
170	R:R:L222	R:R:R218	4.86	No	No	0	4	8
171	R:R:I370	R:R:Y418	6.04	Yes	Yes	1	8	9
172	R:R:F374	R:R:W378	8.02	Yes	Yes	1	9	8
173	R:R:I375	R:R:T379	4.56	No	Yes	0	7	7
174	R:R:T377	R:R:W378	3.64	No	Yes	1	8	8
175	R:R:N410	R:R:T377	7.31	No	No	1	9	8
176	R:R:C407	R:R:W378	16.98	No	Yes	1	8	8
177	R:R:N410	R:R:W378	10.17	No	Yes	1	9	8
178	L:L:?1	R:R:W378	16.25	Yes	Yes	1	0	8
179	R:R:P380	R:R:T379	5.25	No	Yes	0	9	7
180	R:R:L406	R:R:P380	4.93	No	No	0	8	9
181	R:R:N382	R:R:Y381	8.14	No	Yes	1	8	8
182	R:R:V385	R:R:Y381	6.31	No	Yes	0	8	8
183	R:R:Y381	R:R:Y404	3.97	Yes	Yes	1	8	7
184	L:L:?1	R:R:Y381	8.36	Yes	Yes	1	0	8
185	R:R:M384	R:R:W400	4.65	No	Yes	0	6	7
186	R:R:F390	R:R:T389	3.89	No	No	0	5	8
187	R:R:C391	R:R:C394	7.28	No	No	0	6	8
188	R:R:P396	R:R:V395	3.53	No	No	0	6	6
189	R:R:E397	R:R:W400	4.36	No	Yes	0	3	7
190	L:L:?1	R:R:Y404	10.03	Yes	Yes	1	0	7
191	R:R:W405	R:R:Y408	18.33	Yes	Yes	1	8	8
192	L:L:?1	R:R:C407	4.53	Yes	No	1	0	8
193	L:L:?1	R:R:Y408	5.85	Yes	Yes	1	0	8
194	R:R:F429	R:R:L420	4.87	No	No	0	9	7
195	R:R:F425	R:R:N422	8.46	Yes	No	0	9	9
196	R:R:T428	R:R:W437	3.64	No	Yes	3	8	3
197	R:R:L431	R:R:W437	5.69	No	Yes	0	6	3
198	R:R:L433	R:R:R436	6.07	No	No	0	8	4
199	R:R:W437	R:R:W442	3.75	Yes	No	0	3	4
200	R:R:D438	R:R:R440	3.57	No	No	0	4	6
201	R:R:R441	R:R:R443	6.4	No	No	0	8	5
202	R:R:A68	R:R:V46	3.39	No	No	0	9	9
203	R:R:Q177	R:R:Y85	3.38	No	Yes	0	4	7
204	R:R:L117	R:R:P200	3.28	No	No	0	7	9
205	R:R:L199	R:R:P200	3.28	No	No	0	7	9
206	R:R:A108	R:R:I74	3.25	No	No	0	7	8
207	R:R:T58	R:R:V59	3.17	No	Yes	0	8	7
208	R:R:T377	R:R:V409	3.17	No	No	0	8	7
209	R:R:A68	R:R:L47	3.15	No	No	0	9	7
210	R:R:A103	R:R:L162	3.15	No	No	0	8	6
211	R:R:A424	R:R:N422	3.13	No	No	0	7	9
212	R:R:M114	R:R:V152	3.04	No	No	0	7	5
213	R:R:M384	R:R:V395	3.04	No	No	0	6	6
214	R:R:L117	R:R:V203	2.98	No	No	0	7	7
215	R:R:L148	R:R:V152	2.98	No	No	0	4	5
216	R:R:L37	R:R:T41	2.95	No	Yes	0	5	5
217	R:R:L45	R:R:T41	2.95	No	Yes	0	8	5
218	R:R:D71	R:R:S112	2.94	Yes	No	0	9	9
219	R:R:A92	R:R:H90	2.93	No	No	0	4	5
220	R:R:N61	R:R:T58	2.92	No	No	0	9	8
221	R:R:Q185	R:R:S184	2.89	No	No	0	7	6
222	R:R:W400	R:R:Y404	2.89	Yes	Yes	0	7	7
223	R:R:E214	R:R:V127	2.85	No	No	0	7	8
224	R:R:I211	R:R:L367	2.85	No	No	0	9	9
225	R:R:L399	R:R:M384	2.83	No	No	0	5	6
226	R:R:L420	R:R:M416	2.83	No	No	0	7	6
227	R:R:E401	R:R:T398	2.82	No	No	0	6	4
228	R:R:L47	R:R:L65	2.77	No	No	0	7	7
229	R:R:L100	R:R:L96	2.77	No	No	0	6	4
230	R:R:A142	R:R:R137	2.77	No	Yes	0	8	8
231	R:R:A160	R:R:F182	2.77	No	Yes	0	7	6
232	R:R:D427	R:R:K423	2.77	No	No	0	6	5
233	R:R:L72	R:R:N43	2.75	No	Yes	0	8	9
234	R:R:A363	R:R:Y212	2.67	No	Yes	0	9	7
235	R:R:L156	R:R:Q110	2.66	No	Yes	0	8	8
236	R:R:L174	R:R:Q177	2.66	No	No	0	3	4
237	R:R:E214	R:R:N217	2.63	No	No	0	7	5
238	R:R:F429	R:R:V46	2.62	No	No	0	9	9
239	R:R:F154	R:R:V107	2.62	No	No	0	6	8
240	R:R:A70	R:R:W150	2.59	No	No	0	9	9
241	R:R:A97	R:R:W91	2.59	No	Yes	0	6	9
242	R:R:F182	R:R:T189	2.59	Yes	No	0	6	7
243	R:R:R210	R:R:T206	2.59	No	No	0	7	5
244	R:R:S126	R:R:Y133	2.54	No	Yes	0	9	9
245	R:R:S388	R:R:W400	2.47	No	Yes	0	5	7
246	R:R:A97	R:R:G94	1.95	No	No	0	6	7
247	R:R:A175	R:R:G176	1.95	No	No	0	3	2
248	R:R:A158	R:R:P159	1.87	No	No	0	6	8
249	R:R:G169	R:R:V168	1.84	No	Yes	0	4	4
250	R:R:G29	R:R:T32	1.82	No	Yes	0	5	6
251	R:R:G33	R:R:T32	1.82	No	Yes	0	5	6
252	R:R:G42	R:R:T41	1.82	No	Yes	0	9	5
253	R:R:G29	R:R:I28	1.76	No	No	0	5	7
254	R:R:P186	R:R:T389	1.75	No	No	0	5	8
255	R:R:A419	R:R:V46	1.7	No	No	0	8	9
256	R:R:C421	R:R:T366	1.69	No	No	0	8	8
257	R:R:I445	R:R:P446	1.69	No	No	0	7	8
258	R:R:A38	R:R:T412	1.68	No	No	0	5	8
259	R:R:C417	R:R:I370	1.64	No	Yes	0	8	8
260	R:R:C417	R:R:I413	1.64	No	No	0	8	6
261	R:R:A103	R:R:I161	1.62	No	Yes	0	8	7
262	R:R:S126	R:R:V127	1.62	No	No	0	9	8
263	R:R:A373	R:R:I413	1.62	No	No	0	7	6
264	R:R:A149	R:R:M114	1.61	No	No	0	8	7
265	R:R:T41	R:R:V40	1.59	Yes	No	0	5	7
266	R:R:C69	R:R:L47	1.59	No	No	0	6	7
267	R:R:G176	R:R:H90	1.59	No	No	0	2	5
268	R:R:T202	R:R:T206	1.57	No	No	0	5	5
269	R:R:I48	R:R:V52	1.54	No	No	0	6	7
270	R:R:I370	R:R:T366	1.52	Yes	No	0	8	8
271	R:R:I383	R:R:T379	1.52	No	Yes	0	7	7
272	R:R:L44	R:R:V40	1.49	No	No	0	5	7
273	R:R:L167	R:R:V168	1.49	No	Yes	0	4	4
274	R:R:L81	R:R:T84	1.47	No	No	0	7	7
275	R:R:L402	R:R:T398	1.47	No	No	0	5	4
276	R:R:P130	R:R:R129	1.44	No	No	0	8	7
277	R:R:Q24	R:R:V25	1.43	No	No	0	6	4
278	R:R:I30	R:R:L34	1.43	No	No	0	4	5
279	R:R:L118	R:R:M145	1.41	No	No	0	7	7
280	R:R:L100	R:R:L162	1.38	No	No	0	6	6
281	R:R:A143	R:R:R140	1.38	No	No	0	5	6
282	R:R:D393	R:R:K392	1.38	No	No	0	4	4
283	R:R:A193	R:R:Y198	1.33	No	Yes	0	7	7
284	R:R:F154	R:R:V155	1.31	No	No	0	6	5
285	R:R:E221	R:R:N217	1.31	No	No	0	5	5
286	R:R:R140	R:R:T138	1.29	No	No	0	6	8
287	R:R:K423	R:R:R426	1.24	No	No	0	5	9
288	R:R:D438	R:R:R441	1.19	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T32	4.6925	4	0	6
2	R:R:T41	2.3275	4	0	5
3	R:R:N43	5.505	4	0	9
4	R:R:N53	8.755	4	3	8
5	R:R:V59	4.2575	4	0	7
6	R:R:D71	6.2775	4	0	9
7	R:R:Y82	7.384	5	1	7
8	R:R:Y85	4.9025	4	2	7
9	R:R:W91	6.46667	6	2	9
10	R:R:W101	6.1225	4	0	7
11	R:R:Y106	9.25833	6	1	8
12	R:R:Q110	6.27167	6	1	8
13	R:R:L116	4.966	5	1	8
14	R:R:Y133	10.66	4	4	9
15	R:R:R137	9.606	5	4	8
16	R:R:W157	8.168	5	1	8
17	R:R:I161	3.665	4	1	7
18	R:R:W164	9.49	4	0	7
19	R:R:V168	4.505	4	0	4
20	R:R:R171	8.3325	4	2	7
21	R:R:I180	6.325	4	1	7
22	R:R:F182	5.284	5	0	6
23	R:R:F197	9.95	6	1	9
24	R:R:Y198	5.136	5	1	7
25	R:R:Y208	6.63	6	1	9
26	R:R:Y212	6.5825	4	0	7
27	R:R:I370	4.1125	4	1	8
28	R:R:F374	5.642	5	1	9
29	R:R:W378	8.71	8	1	8
30	R:R:T379	3.805	4	0	7
31	R:R:Y381	6.944	5	1	8
32	R:R:W400	3.5925	4	0	7
33	R:R:Y404	7.15	5	1	7
34	R:R:W405	8.398	5	1	8
35	R:R:Y408	9.35333	6	1	8
36	R:R:Y418	5.35	6	1	9
37	R:R:F425	8.31	4	0	9
38	R:R:W437	6.14	5	3	3
39	L:L:?1	9.01083	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T32	R:R:W405	12.5221	7.28	Yes	Yes	0	6	8
2	R:R:D71	R:R:N43	11.2576	6.73	Yes	Yes	0	9	9
3	R:R:D71	R:R:S411	11.8727	7.36	Yes	No	0	9	9
4	R:R:I74	R:R:S411	12.714	9.29	No	No	0	8	9
5	R:R:I74	R:R:S109	19.3269	4.64	No	No	0	8	8
6	L:L:?1	R:R:S109	17.3047	11.78	Yes	No	1	0	8
7	L:L:?1	R:R:Y408	43.2887	5.85	Yes	Yes	1	0	8
8	R:R:W405	R:R:Y408	12.4434	18.33	Yes	Yes	1	8	8
9	R:R:F429	R:R:V46	17.1177	2.62	No	No	0	9	9
10	R:R:A68	R:R:V46	20.4241	3.39	No	No	0	9	9
11	R:R:A68	R:R:L47	22.0626	3.15	No	No	0	9	7
12	R:R:L47	R:R:L65	25.31	2.77	No	No	0	7	7
13	R:R:F50	R:R:L65	26.9189	9.74	No	No	0	8	7
14	R:R:F50	R:R:Y62	30.1073	5.16	No	No	0	8	7
15	R:R:V59	R:R:Y62	31.6867	3.79	Yes	No	0	7	7
16	R:R:R137	R:R:V59	69.0907	6.54	Yes	Yes	0	8	7
17	R:R:D122	R:R:R137	71.3639	9.53	No	Yes	4	9	8
18	R:R:D122	R:R:F63	82.9512	13.14	No	No	0	9	8
19	R:R:F63	R:R:I146	86.5381	6.28	No	No	0	8	9
20	R:R:I146	R:R:S66	87.714	7.74	No	No	0	9	9
21	R:R:N115	R:R:S66	88.8801	4.47	No	No	0	8	9
22	R:R:N115	R:R:W150	90.0364	6.78	No	No	0	8	9
23	R:R:A111	R:R:W150	92.3194	7.78	No	No	0	8	9
24	R:R:A111	R:R:S153	93.4462	3.42	No	No	0	8	8
25	R:R:Q110	R:R:S153	100	5.78	Yes	No	0	8	8
26	L:L:?1	R:R:Q110	89.2196	10.44	Yes	Yes	1	0	8
27	R:R:F429	R:R:L45	12.0842	7.31	No	No	0	9	8
28	R:R:F425	R:R:N61	26.7123	12.08	Yes	No	0	9	9
29	R:R:N61	R:R:T58	29.9006	2.92	No	No	0	9	8
30	R:R:T58	R:R:V59	31.48	3.17	No	Yes	0	8	7
31	R:R:F425	R:R:L56	20.2175	6.09	Yes	No	0	9	9
32	R:R:L56	R:R:N53	18.5692	9.61	No	Yes	0	9	8
33	R:R:P139	R:R:V59	10.3867	3.53	No	Yes	0	5	7
34	R:R:F374	R:R:L116	49.4096	4.87	Yes	Yes	1	9	8
35	R:R:F374	R:R:V113	45.1535	3.93	Yes	No	1	9	9
36	L:L:?1	R:R:V113	45.9211	5.31	Yes	No	1	0	9
37	R:R:F374	R:R:W378	51.8599	8.02	Yes	Yes	1	9	8
38	L:L:?1	R:R:W378	48.6076	16.25	Yes	Yes	1	0	8
39	R:R:L116	R:R:Y418	43.4363	4.69	Yes	Yes	1	8	9
40	R:R:W101	R:R:Y82	40.9467	3.86	Yes	Yes	0	7	7
41	R:R:L86	R:R:Y82	19.3072	9.38	No	Yes	0	7	7
42	R:R:Y404	R:R:Y82	35.0915	11.91	Yes	Yes	1	7	7
43	R:R:L86	R:R:Y85	10.1112	3.52	No	Yes	0	7	7
44	R:R:W101	R:R:W91	31.6522	4.69	Yes	Yes	0	7	9
45	R:R:C98	R:R:W91	19.8731	6.53	No	Yes	2	9	9
46	R:R:D99	R:R:R171	10.1309	10.72	No	Yes	2	7	7
47	R:R:C98	R:R:D99	17.6983	4.67	No	No	2	9	7
48	L:L:?1	R:R:Y106	26.6532	13.38	Yes	Yes	1	0	8
49	R:R:I161	R:R:W157	14.2049	3.52	Yes	Yes	1	7	8
50	R:R:I180	R:R:Y106	33.7483	7.25	Yes	Yes	1	7	8
51	R:R:F374	R:R:M204	49.9459	7.46	Yes	No	1	9	9
52	R:R:F121	R:R:L207	11.4594	8.53	No	No	0	7	8
53	R:R:L207	R:R:S120	24.8918	4.5	No	No	0	8	9
54	R:R:M204	R:R:S120	48.7798	4.6	No	No	0	9	9
55	R:R:Y208	R:R:Y418	25.123	4.96	Yes	Yes	1	9	9
56	R:R:S120	R:R:Y208	24.2767	3.82	No	Yes	0	9	9
57	R:R:D122	R:R:Y133	10.3671	9.2	No	Yes	4	9	9
58	R:R:L207	R:R:Y124	11.4594	15.24	No	No	0	8	8
59	R:R:A103	R:R:I161	11.1395	1.62	No	Yes	0	8	7
60	R:R:F182	R:R:I180	37.6353	5.02	Yes	Yes	0	6	7
61	R:R:F182	R:R:W164	22.4808	11.02	Yes	Yes	0	6	7
62	R:R:F197	R:R:Y198	11.9957	11.35	Yes	Yes	1	9	7
63	L:L:?1	R:R:F197	14.756	5.21	Yes	Yes	1	0	9
64	R:R:L367	R:R:Y208	35.7361	7.03	No	Yes	0	9	9
65	R:R:I370	R:R:Y418	13.6636	6.04	Yes	Yes	1	8	9
66	R:R:E216	R:R:Y212	13.4718	13.47	No	Yes	0	7	7
67	R:R:L367	R:R:Y212	26.8599	3.52	No	Yes	0	9	7
68	R:R:W400	R:R:Y404	10.2588	2.89	Yes	Yes	0	7	7
69	L:L:?1	R:R:Y404	35.8738	10.03	Yes	Yes	1	0	7
70	R:R:Y408	R:R:Y82	27.8636	6.95	Yes	Yes	1	8	7
71	R:R:Q110	R:R:W157	17.964	8.76	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I74	R:R:S109	4.64	0	No	No	8	8	2	1
R:R:D105	R:R:S78	10.31	1	No	No	9	8	1	2
R:R:S78	R:R:Y408	3.82	1	No	Yes	8	8	2	1
R:R:M79	R:R:W405	8.14	1	No	Yes	8	8	2	2
R:R:M79	R:R:Y408	11.97	1	No	Yes	8	8	2	1
R:R:Y404	R:R:Y82	11.91	1	Yes	Yes	7	7	1	2
R:R:W405	R:R:Y82	4.82	1	Yes	Yes	8	7	2	2
R:R:Y408	R:R:Y82	6.95	1	Yes	Yes	8	7	1	2
R:R:D105	R:R:Y408	9.2	1	No	Yes	9	8	1	1
L:L:?1	R:R:D105	9.68	1	Yes	No	0	9	0	1
R:R:W157	R:R:Y106	16.4	1	Yes	Yes	8	8	1	1
R:R:I161	R:R:Y106	3.63	1	Yes	Yes	7	8	2	1
R:R:I180	R:R:Y106	7.25	1	Yes	Yes	7	8	2	1
R:R:Y106	R:R:Y381	7.94	1	Yes	Yes	8	8	1	1
R:R:Y106	R:R:Y404	6.95	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y106	13.38	1	Yes	Yes	0	8	0	1
R:R:S109	R:R:W378	3.71	1	No	Yes	8	8	1	1
L:L:?1	R:R:S109	11.78	1	Yes	No	0	8	0	1
R:R:M114	R:R:Q110	5.44	0	No	Yes	7	8	2	1
R:R:Q110	R:R:S153	5.78	1	Yes	No	8	8	1	2
R:R:Q110	R:R:W157	8.76	1	Yes	Yes	8	8	1	1
R:R:A196	R:R:Q110	4.55	0	No	Yes	8	8	2	1
L:L:?1	R:R:Q110	10.44	1	Yes	Yes	0	8	0	1
R:R:F374	R:R:V113	3.93	1	Yes	No	9	9	2	1
R:R:V113	R:R:W378	4.9	1	No	Yes	9	8	1	1
L:L:?1	R:R:V113	5.31	1	Yes	No	0	9	0	1
R:R:I161	R:R:W157	3.52	1	Yes	Yes	7	8	2	1
R:R:T192	R:R:W157	4.85	0	No	Yes	8	8	2	1
L:L:?1	R:R:W157	7.31	1	Yes	Yes	0	8	0	1
R:R:I161	R:R:I180	5.89	1	Yes	Yes	7	7	2	2
R:R:F197	R:R:Y198	11.35	1	Yes	Yes	9	7	1	2
R:R:F197	R:R:V201	7.87	1	Yes	No	9	7	1	2
R:R:F197	R:R:W378	6.01	1	Yes	Yes	9	8	1	1
R:R:F197	R:R:T379	3.89	1	Yes	Yes	9	7	1	2
R:R:F197	R:R:N382	25.37	1	Yes	No	9	8	1	2
L:L:?1	R:R:F197	5.21	1	Yes	Yes	0	9	0	1
R:R:N382	R:R:Y198	3.49	1	No	Yes	8	7	2	2
R:R:F374	R:R:V201	3.93	1	Yes	No	9	7	2	2
R:R:F374	R:R:W378	8.02	1	Yes	Yes	9	8	2	1
R:R:T377	R:R:W378	3.64	1	No	Yes	8	8	2	1
R:R:N410	R:R:T377	7.31	1	No	No	9	8	2	2
R:R:C407	R:R:W378	16.98	1	No	Yes	8	8	1	1
R:R:N410	R:R:W378	10.17	1	No	Yes	9	8	2	1
L:L:?1	R:R:W378	16.25	1	Yes	Yes	0	8	0	1
R:R:N382	R:R:Y381	8.14	1	No	Yes	8	8	2	1
R:R:V385	R:R:Y381	6.31	0	No	Yes	8	8	2	1
R:R:Y381	R:R:Y404	3.97	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:Y381	8.36	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y404	10.03	1	Yes	Yes	0	7	0	1
R:R:W405	R:R:Y408	18.33	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:C407	4.53	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y408	5.85	1	Yes	Yes	0	8	0	1
R:R:W400	R:R:Y404	2.89	0	Yes	Yes	7	7	2	1
R:R:L156	R:R:Q110	2.66	0	No	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OIJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	261
Number of Links	288
Number of Hubs	39
Number of Links mediated by Hubs	151
Number of Communities	6
Number of Nodes involved in Communities	52
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	48574
Length Of Smallest Path	3
Average Path Length	13.8655
Length of Longest Path	32
Minimum Path Strength	1.335
Average Path Strength	6.61939
Maximum Path Strength	16.755
Minimum Path Correlation	0.7
Average Path Correlation	0.945051
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	62.0739
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.6811
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • phosphoric ester hydrolase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • phospholipase C activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • phospholipase activity • lipase activity • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • regulation of body fluid levels • secretion by tissue • digestive system process • secretion • body fluid secretion • digestion • saliva secretion • regulation of biological quality • cognition • regulation of postsynaptic membrane potential • regulation of membrane potential • trans-synaptic signaling • chemical synaptic transmission • anterograde trans-synaptic signaling • neuromuscular synaptic transmission • regulation of signaling • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • regulation of cell communication • nervous system development • cellular developmental process • neurogenesis • regulation of glial cell proliferation • gliogenesis • cell differentiation • regulation of cell population proliferation • glial cell proliferation • establishment of protein localization • cellular localization • nitrogen compound transport • regulation of protein localization • positive regulation of establishment of protein localization • positive regulation of protein transport • establishment of localization in cell • positive regulation of intracellular transport • intracellular protein localization • positive regulation of cellular process • regulation of intracellular transport • regulation of establishment of protein localization • intracellular transport • regulation of protein transport • protein transport • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • intracellular protein transport • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • cholinergic synapse • glutamatergic synapse • Schaffer collateral - CA1 synapse • axon • axon terminus • distal axon • neuron projection terminus • enzyme regulator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • heart development • circulatory system development • circulatory system process • regulation of blood pressure • blood circulation • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • skeletal system development • cranial skeletal system development • action potential • pigment cell differentiation • regulation of developmental process • developmental pigmentation • regulation of pigment cell differentiation • regulation of cell differentiation • pigmentation • melanocyte differentiation • regulation of melanocyte differentiation • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to abiotic stimulus • cellular response to environmental stimulus • endothelin receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • positive regulation of cell communication • positive regulation of insulin secretion • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • amide transport • signal release • positive regulation of peptide secretion • regulation of peptide transport • export from cell • positive regulation of protein secretion • peptide transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • positive regulation of signaling • ligand-gated ion channel signaling pathway • phospholipase C-activating dopamine receptor signaling pathway
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IXO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IXO
Name	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Synonyms	Iperoxo
Identifier
Formula	C10 H17 N2 O2
Molecular Weight	197.254
SMILES
PubChem	10104167
Formal Charge	1
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P11229
Sequence	>6OIJ_nogp_Chain_R P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T E L K T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G H W A L G T L A C D L W L A L D Y V A S Q A S V M N L L L I S F D R Y F S V T R P L S Y R A K R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G E R T V L A G Q C Y I Q F L S Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L Q G E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C K D C V P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R D T F R L L L L C R W D K R R W R K I P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WJC	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	Muscarinic toxin 7	-	2.55	2020-07-08	doi.org/10.1126/science.aax2517
	6ZFZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	77-LH-28-1	-	-	2.17	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG4	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	HTL0009936	-	-	2.33	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG9	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	GSK1034702	-	-	2.5	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	5CXV	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Tiotropium	-	-	2.7	2016-03-09	doi.org/10.1038/nature17188
	6OIJ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	chim(NtGi1L-G11)/β1/γ2	3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIJ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-		3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	9JEA	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-	-	3.4	2025-07-09	To be published
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	4ZUD	A	Peptide	Angiotensin	AT₁	Homo sapiens	Olmesartan	-	-	2.8	2015-10-07	doi.org/10.1074/jbc.M115.689000
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	9M1H	A	Lipid	Prostanoid	EP₁	Homo sapiens	Prostaglandin E2	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-04-09	To be published
	9M1H (No Gprot)	A	Lipid	Prostanoid	EP₁	Homo sapiens	Prostaglandin E2	-		2.55	2025-04-09	To be published
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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