psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y42	4.13	Yes	Yes	0	0	7
2	L:L:?1	R:R:Q91	28.11	Yes	No	0	0	6
3	L:L:?1	R:R:V109	7.86	Yes	No	0	0	5
4	L:L:?1	R:R:Y113	15.13	Yes	Yes	1	0	6
5	L:L:?1	R:R:Y172	8.94	Yes	Yes	0	0	4
6	L:L:?1	R:R:F254	11.43	Yes	No	1	0	7
7	L:L:?1	R:R:V257	4.37	Yes	Yes	0	0	5
8	L:L:?1	R:R:L258	5.68	Yes	No	0	0	5
9	L:L:?1	R:R:T282	6.92	Yes	No	0	0	4
10	L:L:?1	R:R:E286	24.87	Yes	No	1	0	5
11	R:R:F41	R:R:L37	6.09	No	No	0	4	5
12	R:R:L38	R:R:Y42	5.86	No	Yes	0	6	7
13	R:R:H283	R:R:L38	5.14	No	No	0	4	6
14	R:R:L44	R:R:V40	4.47	No	No	0	5	5
15	R:R:F290	R:R:Y42	7.22	Yes	Yes	0	7	7
16	R:R:F46	R:R:P89	7.22	No	No	0	7	8
17	R:R:S49	R:R:V85	9.7	No	No	0	8	6
18	R:R:L50	R:R:S54	4.5	No	No	0	6	4
19	R:R:G52	R:R:P297	4.06	No	No	0	8	9
20	R:R:D81	R:R:N53	6.73	No	No	0	9	9
21	R:R:L82	R:R:N53	4.12	No	No	0	7	9
22	R:R:N53	R:R:P297	4.89	No	No	0	9	9
23	R:R:F302	R:R:L55	9.74	Yes	No	0	6	6
24	R:R:L311	R:R:L55	4.15	No	No	0	6	6
25	R:R:F307	R:R:V56	5.24	Yes	No	0	8	9
26	R:R:I57	R:R:L75	5.71	Yes	No	0	7	6
27	R:R:I57	R:R:L79	4.28	Yes	No	0	7	6
28	R:R:L58	R:R:V62	5.96	No	No	0	3	5
29	R:R:F307	R:R:V59	11.8	Yes	No	0	8	7
30	R:R:H310	R:R:V59	4.15	No	No	0	4	7
31	R:R:I314	R:R:V59	4.61	No	No	0	4	7
32	R:R:L60	R:R:L75	4.15	No	No	0	7	6
33	R:R:C63	R:R:I314	8.18	No	No	0	5	4
34	R:R:K64	R:R:R67	12.38	No	No	0	5	6
35	R:R:E313	R:R:K64	6.75	No	No	0	5	5
36	R:R:L66	R:R:V72	5.96	No	No	0	6	6
37	R:R:L66	R:R:L75	5.54	No	No	0	6	6
38	R:R:H310	R:R:R67	4.51	No	No	0	4	6
39	R:R:S68	R:R:T70	4.8	No	No	2	7	8
40	R:R:D71	R:R:S68	4.42	No	No	2	8	7
41	R:R:I69	R:R:Y73	9.67	Yes	Yes	2	6	7
42	R:R:D130	R:R:I69	7	No	Yes	2	8	6
43	R:R:I69	R:R:R145	8.77	Yes	Yes	2	6	7
44	R:R:D71	R:R:T70	4.34	No	No	2	8	8
45	R:R:D71	R:R:K306	4.15	No	No	0	8	6
46	R:R:L126	R:R:Y73	11.72	No	Yes	0	7	7
47	R:R:M127	R:R:Y73	4.79	No	Yes	0	9	7
48	R:R:D130	R:R:Y73	8.05	No	Yes	2	8	7
49	R:R:A301	R:R:L74	4.73	No	No	0	7	8
50	R:R:F123	R:R:N76	14.5	Yes	No	3	8	9
51	R:R:C154	R:R:N76	11.02	No	No	3	7	9
52	R:R:N76	R:R:W158	5.65	No	No	3	9	9
53	R:R:F123	R:R:L77	4.87	Yes	No	0	8	9
54	R:R:S119	R:R:S80	6.52	No	No	0	7	8
55	R:R:D81	R:R:N296	5.39	No	No	0	9	9
56	R:R:F112	R:R:L83	9.74	No	No	0	5	6
57	R:R:F84	R:R:F88	4.29	Yes	Yes	1	6	7
58	R:R:F84	R:R:Y113	15.47	Yes	Yes	1	6	6
59	R:R:F84	R:R:G116	4.52	Yes	No	0	6	8
60	R:R:F290	R:R:F84	6.43	Yes	Yes	1	7	6
61	R:R:F88	R:R:V85	5.24	Yes	No	0	7	6
62	R:R:F290	R:R:F88	11.79	Yes	Yes	1	7	7
63	R:R:F101	R:R:F90	12.86	Yes	No	0	7	6
64	R:R:F90	R:R:V109	5.24	No	No	0	6	5
65	R:R:Q91	R:R:Y94	7.89	No	No	0	6	5
66	R:R:D97	R:R:Y93	8.05	No	No	0	4	2
67	R:R:V100	R:R:Y93	10.09	No	No	0	3	2
68	R:R:F101	R:R:Y93	7.22	Yes	No	0	7	2
69	R:R:Q182	R:R:Y94	9.02	No	No	0	4	5
70	R:R:L181	R:R:Q98	5.32	No	No	0	4	4
71	R:R:F101	R:R:W99	22.05	Yes	Yes	0	7	9
72	R:R:C106	R:R:W99	5.22	No	Yes	5	9	9
73	R:R:C183	R:R:W99	13.06	No	Yes	5	9	9
74	R:R:T103	R:R:V174	7.93	No	No	0	2	5
75	R:R:M105	R:R:V108	6.09	No	No	0	6	5
76	R:R:C106	R:R:C183	7.28	No	No	5	9	9
77	R:R:S110	R:R:Y172	13.99	No	Yes	0	5	4
78	R:R:G111	R:R:L169	5.13	No	No	0	5	4
79	R:R:Y113	R:R:Y114	5.96	Yes	Yes	0	6	5
80	R:R:E286	R:R:Y113	5.61	No	Yes	1	5	6
81	R:R:L168	R:R:Y114	17.58	No	Yes	0	4	5
82	R:R:Y114	R:R:Y172	7.94	Yes	Yes	0	5	4
83	R:R:M202	R:R:Y114	5.99	No	Yes	0	5	5
84	R:R:I115	R:R:I162	4.42	No	No	0	5	3
85	R:R:I115	R:R:T165	10.64	No	No	0	5	7
86	R:R:F117	R:R:Y118	15.47	Yes	Yes	6	8	7
87	R:R:F117	R:R:M121	6.22	Yes	No	0	8	7
88	R:R:F117	R:R:M202	6.22	Yes	No	6	8	5
89	R:R:F122	R:R:Y118	4.13	Yes	Yes	0	5	7
90	R:R:A164	R:R:Y118	8.01	No	Yes	0	5	7
91	R:R:K201	R:R:Y118	8.36	No	Yes	0	4	7
92	R:R:M202	R:R:Y118	9.58	No	Yes	6	5	7
93	R:R:S119	R:R:W158	7.41	No	No	0	7	9
94	R:R:H292	R:R:S120	6.97	Yes	No	0	9	9
95	R:R:M121	R:R:W251	19.78	No	Yes	0	7	9
96	R:R:F122	R:R:V157	6.55	Yes	No	0	5	6
97	R:R:C154	R:R:F123	6.98	No	Yes	3	7	8
98	R:R:F123	R:R:V157	13.11	Yes	No	0	8	6
99	R:R:F123	R:R:W158	10.02	Yes	No	3	8	9
100	R:R:I124	R:R:Y300	4.84	No	Yes	0	8	9
101	R:R:P210	R:R:T125	5.25	No	No	0	9	7
102	R:R:I213	R:R:T125	4.56	No	No	0	7	7
103	R:R:L126	R:R:L153	4.15	No	No	0	7	6
104	R:R:M127	R:R:Y300	11.97	No	Yes	0	9	9
105	R:R:C217	R:R:S128	5.16	No	No	0	7	9
106	R:R:S128	R:R:Y218	5.09	No	Yes	0	9	9
107	R:R:D130	R:R:R145	14.29	No	Yes	2	8	7
108	R:R:R131	R:R:Y218	9.26	No	Yes	0	9	9
109	R:R:R131	R:R:Y300	7.2	No	Yes	0	9	9
110	R:R:V136	R:R:Y132	12.62	No	Yes	4	7	8
111	R:R:H137	R:R:Y132	8.71	No	Yes	4	6	8
112	R:R:C217	R:R:Y132	8.06	No	Yes	0	7	8
113	R:R:K220	R:R:Y132	10.75	No	Yes	4	4	8
114	R:R:A134	R:R:R145	5.53	No	Yes	0	8	7
115	R:R:I221	R:R:V135	7.68	No	No	0	8	8
116	R:R:H137	R:R:V136	12.45	No	No	4	6	7
117	R:R:K220	R:R:V136	4.55	No	No	4	4	7
118	R:R:V144	R:R:Y140	5.05	No	No	0	4	4
119	R:R:L168	R:R:T198	8.84	No	No	0	4	6
120	R:R:F171	R:R:V170	7.87	No	No	0	4	3
121	R:R:F171	R:R:Y187	20.63	No	Yes	0	4	5
122	R:R:F171	R:R:W194	4.01	No	No	0	4	2
123	R:R:S185	R:R:Y172	7.63	No	Yes	0	4	4
124	R:R:F186	R:R:Q173	5.86	No	No	0	4	4
125	R:R:E177	R:R:Q182	8.92	No	No	0	1	4
126	R:R:E177	R:R:Y184	12.35	No	No	0	1	2
127	R:R:S185	R:R:Y187	7.63	No	Yes	0	4	5
128	R:R:F186	R:R:N188	7.25	No	No	0	4	3
129	R:R:K195	R:R:Y187	11.94	No	Yes	0	5	5
130	R:R:K193	R:R:W194	17.4	No	No	0	2	2
131	R:R:K201	R:R:T198	9.01	No	No	0	4	6
132	R:R:L258	R:R:N199	6.87	No	No	0	5	5
133	R:R:N199	R:R:S262	8.94	No	No	0	5	5
134	R:R:F200	R:R:F259	6.43	No	No	0	5	6
135	R:R:F200	R:R:S262	6.61	No	No	0	5	5
136	R:R:N203	R:R:N255	10.9	No	No	0	6	8
137	R:R:G206	R:R:P210	4.06	No	No	0	5	9
138	R:R:F211	R:R:L207	8.53	Yes	No	0	7	8
139	R:R:L207	R:R:N255	21.97	No	No	0	8	8
140	R:R:I209	R:R:P210	5.08	No	No	0	6	9
141	R:R:F211	R:R:F214	4.29	Yes	Yes	0	7	8
142	R:R:F211	R:R:W251	6.01	Yes	Yes	0	7	9
143	R:R:F214	R:R:Y218	11.35	Yes	Yes	0	8	9
144	R:R:F214	R:R:S247	6.61	Yes	No	0	8	9
145	R:R:F216	R:R:K220	4.96	No	No	0	4	4
146	R:R:V240	R:R:Y218	7.57	No	Yes	0	7	9
147	R:R:I237	R:R:L222	5.71	Yes	No	0	7	5
148	R:R:L222	R:R:V240	5.96	No	No	0	5	7
149	R:R:Q224	R:R:R227	4.67	No	No	0	5	5
150	R:R:I237	R:R:L225	4.28	Yes	No	0	7	8
151	R:R:C228	R:R:N230	4.72	No	No	0	6	4
152	R:R:K235	R:R:R238	8.66	No	No	0	7	6
153	R:R:L239	R:R:V303	4.47	No	No	0	8	7
154	R:R:I242	R:R:I299	4.42	No	No	0	5	8
155	R:R:V243	R:R:Y300	5.05	No	Yes	0	8	9
156	R:R:I245	R:R:L249	4.28	No	No	0	5	6
157	R:R:F250	R:R:T291	7.78	Yes	No	0	8	5
158	R:R:F250	R:R:H292	4.53	Yes	Yes	0	8	9
159	R:R:F250	R:R:V295	7.87	Yes	No	0	8	6
160	R:R:F254	R:R:W251	6.01	No	Yes	1	7	9
161	R:R:S289	R:R:W251	6.18	No	Yes	1	8	9
162	R:R:H292	R:R:W251	11.64	Yes	Yes	0	9	9
163	R:R:F254	R:R:S289	14.53	No	No	1	7	8
164	R:R:T285	R:R:V257	6.35	No	Yes	0	6	5
165	R:R:F259	R:R:L263	7.31	No	No	0	6	4
166	R:R:L263	R:R:L269	4.15	No	No	0	4	2
167	R:R:D270	R:R:H267	8.82	No	No	0	1	1
168	R:R:G271	R:R:I274	5.29	No	No	0	3	3
169	R:R:Q277	R:R:S273	5.78	No	No	0	3	1
170	R:R:E286	R:R:F290	9.33	No	Yes	1	5	7
171	R:R:F290	R:R:I287	6.28	Yes	No	0	7	5
172	R:R:H292	R:R:N296	6.38	Yes	No	0	9	9
173	R:R:N296	R:R:Y300	5.81	No	Yes	0	9	9
174	R:R:F302	R:R:P297	4.33	Yes	No	0	6	9
175	R:R:F302	R:R:V298	5.24	Yes	No	0	6	6
176	R:R:A301	R:R:F307	8.32	No	Yes	0	7	8
177	R:R:F302	R:R:F307	4.29	Yes	Yes	0	6	8
178	R:R:E313	R:R:K309	5.4	No	No	0	5	5
179	R:R:E313	R:R:K317	4.05	No	No	0	5	4
180	R:R:L95	R:R:Q91	3.99	No	No	0	5	6
181	R:R:H223	R:R:I219	3.98	No	No	0	3	4
182	R:R:F46	R:R:V85	3.93	No	No	0	7	6
183	R:R:F214	R:R:V244	3.93	Yes	No	0	8	8
184	R:R:D270	R:R:H264	3.78	No	No	0	1	2
185	R:R:T92	R:R:Y42	3.75	No	Yes	0	7	7
186	R:R:T191	R:R:Y187	3.75	No	Yes	0	3	5
187	R:R:K65	R:R:R67	3.71	No	No	0	6	6
188	R:R:V174	R:R:W99	3.68	No	Yes	0	5	9
189	R:R:F88	R:R:L45	3.65	Yes	No	0	7	7
190	R:R:F46	R:R:L50	3.65	No	No	0	7	6
191	R:R:F122	R:R:L205	3.65	Yes	No	0	5	5
192	R:R:F211	R:R:L248	3.65	Yes	No	0	7	6
193	R:R:G150	R:R:I69	3.53	No	Yes	0	7	6
194	R:R:P253	R:R:V252	3.53	No	No	0	9	5
195	R:R:P253	R:R:T285	3.5	No	No	0	9	6
196	R:R:C293	R:R:S49	3.44	No	No	0	8	8
197	R:R:C217	R:R:V129	3.42	No	No	0	7	6
198	R:R:A78	R:R:V56	3.39	No	No	0	9	9
199	R:R:I166	R:R:P167	3.39	No	No	0	4	8
200	R:R:A281	R:R:V257	3.39	No	Yes	0	5	5
201	R:R:A78	R:R:I57	3.25	No	Yes	0	9	7
202	R:R:A236	R:R:L225	3.15	No	No	0	7	8
203	R:R:I69	R:R:S68	3.1	Yes	No	2	6	7
204	R:R:I299	R:R:V243	3.07	No	No	0	8	8
205	R:R:I299	R:R:V295	3.07	No	No	0	8	6
206	R:R:C272	R:R:Q276	3.05	No	No	0	8	3
207	R:R:K143	R:R:V144	3.04	No	No	0	5	4
208	R:R:M215	R:R:V244	3.04	No	No	0	4	8
209	R:R:F117	R:R:G206	3.01	Yes	No	0	8	5
210	R:R:L169	R:R:S110	3	No	No	0	4	5
211	R:R:L181	R:R:S176	3	No	No	0	4	3
212	R:R:K233	R:R:T234	3	No	No	0	6	4
213	R:R:L51	R:R:V47	2.98	No	No	0	4	6
214	R:R:I196	R:R:M266	2.92	No	No	0	3	3
215	R:R:I219	R:R:M215	2.92	No	No	0	4	4
216	R:R:Q276	R:R:S273	2.89	No	No	0	3	1
217	R:R:Q224	R:R:V135	2.87	No	No	0	5	8
218	R:R:I115	R:R:L83	2.85	No	No	0	5	6
219	R:R:I204	R:R:L205	2.85	No	No	0	5	5
220	R:R:I204	R:R:L208	2.85	No	No	0	5	4
221	R:R:I221	R:R:L225	2.85	No	No	0	8	8
222	R:R:I268	R:R:L269	2.85	No	No	0	1	2
223	R:R:I274	R:R:L278	2.85	No	No	0	3	5
224	R:R:K235	R:R:L239	2.82	No	No	0	7	8
225	R:R:G102	R:R:W99	2.81	No	Yes	0	8	9
226	R:R:A141	R:R:R145	2.77	No	Yes	0	6	7
227	R:R:L222	R:R:L241	2.77	No	No	0	5	5
228	R:R:A246	R:R:F250	2.77	No	Yes	0	6	8
229	R:R:E305	R:R:K309	2.7	No	No	0	4	5
230	R:R:F88	R:R:S87	2.64	Yes	No	0	7	7
231	R:R:N188	R:R:Q190	2.64	No	No	0	3	4
232	R:R:F41	R:R:V40	2.62	No	No	0	4	5
233	R:R:F122	R:R:T160	2.59	Yes	No	0	5	4
234	R:R:R148	R:R:T146	2.59	No	No	0	4	7
235	R:R:T165	R:R:Y114	2.5	No	Yes	0	7	5
236	R:R:T165	R:R:Y118	2.5	No	Yes	0	7	7
237	R:R:T279	R:R:Y280	2.5	No	No	0	4	3
238	R:R:F86	R:R:L82	2.44	No	No	0	4	7
239	R:R:F186	R:R:Y184	2.06	No	No	0	4	2
240	R:R:F197	R:R:W194	2	No	No	0	4	2
241	R:R:G179	R:R:S176	1.86	No	No	0	4	3
242	R:R:G179	R:R:V180	1.84	No	No	0	4	3
243	R:R:G150	R:R:M149	1.75	No	No	0	7	3
244	R:R:C294	R:R:S49	1.72	No	No	0	7	8
245	R:R:G34	R:R:L37	1.71	No	No	0	4	5
246	R:R:G52	R:R:L51	1.71	No	No	0	8	4
247	R:R:A161	R:R:S119	1.71	No	No	0	8	7
248	R:R:G34	R:R:N33	1.7	No	No	0	4	2
249	R:R:C43	R:R:T92	1.69	No	No	0	4	7
250	R:R:V61	R:R:V62	1.6	No	No	0	4	5
251	R:R:V104	R:R:V108	1.6	No	No	0	4	5
252	R:R:V252	R:R:V256	1.6	No	No	0	5	6
253	R:R:S265	R:R:T261	1.6	No	No	0	3	4
254	R:R:S275	R:R:T279	1.6	No	No	0	1	4
255	R:R:T151	R:R:V72	1.59	No	No	0	3	6
256	R:R:T261	R:R:V257	1.59	No	Yes	0	4	5
257	R:R:T285	R:R:V284	1.59	No	No	0	6	6
258	R:R:A39	R:R:L95	1.58	No	No	0	5	5
259	R:R:A141	R:R:L133	1.58	No	No	0	6	5
260	R:R:I196	R:R:S265	1.55	No	No	0	3	3
261	R:R:I57	R:R:V61	1.54	Yes	No	0	7	4
262	R:R:I147	R:R:V72	1.54	No	No	0	3	6
263	R:R:I147	R:R:T146	1.52	No	No	0	3	7
264	R:R:L133	R:R:V144	1.49	No	No	0	5	4
265	R:R:L260	R:R:V256	1.49	No	No	0	4	6
266	R:R:L278	R:R:T261	1.47	No	No	0	5	4
267	R:R:I237	R:R:K226	1.45	Yes	No	0	7	4
268	R:R:I237	R:R:K233	1.45	Yes	No	0	7	6
269	R:R:Q98	R:R:V100	1.43	No	No	0	4	3
270	R:R:Q182	R:R:V180	1.43	No	No	0	4	3
271	R:R:I196	R:R:L192	1.43	No	No	0	3	1
272	R:R:K35	R:R:L95	1.41	No	No	0	4	5
273	R:R:L159	R:R:M163	1.41	No	No	0	4	4
274	R:R:C294	R:R:F48	1.4	No	No	0	7	5
275	R:R:H264	R:R:S265	1.39	No	No	0	2	3
276	R:R:H264	R:R:S275	1.39	No	No	0	2	1
277	R:R:L248	R:R:L249	1.38	No	No	0	6	6
278	R:R:A175	R:R:Y184	1.33	No	No	0	1	2
279	R:R:L192	R:R:Q189	1.33	No	No	0	1	4
280	R:R:H231	R:R:N232	1.28	No	No	0	3	5
281	R:R:F101	R:R:M105	1.24	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.744	10	1	0
2	R:R:Y42	5.24	4	0	7
3	R:R:I57	3.695	4	0	7
4	R:R:I69	6.414	5	2	6
5	R:R:Y73	8.5575	4	2	7
6	R:R:F84	7.6775	4	1	6
7	R:R:F88	5.522	5	1	7
8	R:R:W99	9.364	5	5	9
9	R:R:F101	10.8425	4	0	7
10	R:R:Y113	10.5425	4	1	6
11	R:R:Y114	7.994	5	0	5
12	R:R:F117	7.73	4	6	8
13	R:R:Y118	8.00833	6	6	7
14	R:R:F122	4.23	4	0	5
15	R:R:F123	9.896	5	3	8
16	R:R:Y132	10.035	4	4	8
17	R:R:R145	7.84	4	2	7
18	R:R:Y172	9.625	4	0	4
19	R:R:Y187	10.9875	4	0	5
20	R:R:F211	5.62	4	0	7
21	R:R:F214	6.545	4	0	8
22	R:R:Y218	8.3175	4	0	9
23	R:R:I237	3.2225	4	0	7
24	R:R:F250	5.7375	4	0	8
25	R:R:W251	9.924	5	1	9
26	R:R:V257	3.925	4	0	5
27	R:R:F290	8.21	5	1	7
28	R:R:H292	7.38	4	0	9
29	R:R:Y300	6.974	5	0	9
30	R:R:F302	5.9	4	0	6
31	R:R:F307	7.4125	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y42	26.0907	4.13	Yes	Yes	0	0	7
2	L:L:?1	R:R:E286	18.2968	24.87	Yes	No	1	0	5
3	R:R:E286	R:R:F290	17.8834	9.33	No	Yes	1	5	7
4	R:R:F290	R:R:Y42	17.6982	7.22	Yes	Yes	0	7	7
5	R:R:F290	R:R:F88	30.0525	11.79	Yes	Yes	1	7	7
6	R:R:F88	R:R:V85	37.6489	5.24	Yes	No	0	7	6
7	R:R:F46	R:R:V85	16.8528	3.93	No	No	0	7	6
8	L:L:?1	R:R:Y113	41.9994	15.13	Yes	Yes	1	0	6
9	R:R:F84	R:R:Y113	23.5298	15.47	Yes	Yes	1	6	6
10	R:R:F84	R:R:F88	19.7655	4.29	Yes	Yes	1	6	7
11	R:R:S49	R:R:V85	16.8528	9.7	No	No	0	8	6
12	L:L:?1	R:R:F254	100	11.43	Yes	No	1	0	7
13	R:R:F254	R:R:W251	99.1546	6.01	No	Yes	1	7	9
14	R:R:H292	R:R:W251	88.0346	11.64	Yes	Yes	0	9	9
15	R:R:H292	R:R:N296	81.6908	6.38	Yes	No	0	9	9
16	R:R:D81	R:R:N296	62.4067	5.39	No	No	0	9	9
17	R:R:D81	R:R:N53	61.1169	6.73	No	No	0	9	9
18	R:R:N53	R:R:P297	57.1737	4.89	No	No	0	9	9
19	R:R:F302	R:R:P297	51.7433	4.33	Yes	No	0	6	9
20	R:R:F302	R:R:F307	46.2512	4.29	Yes	Yes	0	6	8
21	R:R:F307	R:R:V56	25.4366	5.24	Yes	No	0	8	9
22	R:R:A78	R:R:V56	23.8383	3.39	No	No	0	9	9
23	R:R:A78	R:R:I57	22.2092	3.25	No	Yes	0	9	7
24	R:R:I57	R:R:L75	13.9155	5.71	Yes	No	0	7	6
25	R:R:F307	R:R:V59	18.4573	11.8	Yes	No	0	8	7
26	R:R:H310	R:R:V59	13.755	4.15	No	No	0	4	7
27	R:R:H310	R:R:R67	12.0642	4.51	No	No	0	4	6
28	R:R:L66	R:R:L75	10.5091	5.54	No	No	0	6	6
29	R:R:N296	R:R:Y300	48.7689	5.81	No	Yes	0	9	9
30	R:R:M127	R:R:Y300	41.7772	11.97	No	Yes	0	9	9
31	R:R:M127	R:R:Y73	40.4196	4.79	No	Yes	0	9	7
32	R:R:I69	R:R:Y73	22.7707	9.67	Yes	Yes	2	6	7
33	R:R:D130	R:R:Y73	13.2613	8.05	No	Yes	2	8	7
34	R:R:D130	R:R:R145	11.6569	14.29	No	Yes	2	8	7
35	R:R:Y113	R:R:Y114	30.9102	5.96	Yes	Yes	0	6	5
36	R:R:M202	R:R:Y114	28.0963	5.99	No	Yes	0	5	5
37	R:R:M202	R:R:Y118	18.9077	9.58	No	Yes	6	5	7
38	R:R:F122	R:R:Y118	42.7584	4.13	Yes	Yes	0	5	7
39	R:R:F122	R:R:V157	27.763	6.55	Yes	No	0	5	6
40	R:R:F123	R:R:V157	24.7269	13.11	Yes	No	0	8	6
41	L:L:?1	R:R:Y172	42.0796	8.94	Yes	Yes	0	0	4
42	R:R:Y114	R:R:Y172	28.7874	7.94	Yes	Yes	0	5	4
43	R:R:T165	R:R:Y114	24.3135	2.5	No	Yes	0	7	5
44	R:R:T165	R:R:Y118	23.0484	2.5	No	Yes	0	7	7
45	R:R:F123	R:R:W158	12.4344	10.02	Yes	No	3	8	9
46	L:L:?1	R:R:V109	34.7177	7.86	Yes	No	0	0	5
47	R:R:F90	R:R:V109	32.9651	5.24	No	No	0	6	5
48	R:R:F101	R:R:F90	30.9904	12.86	Yes	No	0	7	6
49	L:L:?1	R:R:Q91	34.7177	28.11	Yes	No	0	0	6
50	R:R:Q91	R:R:Y94	26.967	7.89	No	No	0	6	5
51	R:R:F101	R:R:Y93	10.6881	7.22	Yes	No	0	7	2
52	R:R:Q182	R:R:Y94	24.9553	9.02	No	No	0	4	5
53	R:R:F101	R:R:W99	12.9158	22.05	Yes	Yes	0	7	9
54	R:R:M121	R:R:W251	27.4668	19.78	No	Yes	0	7	9
55	R:R:F117	R:R:M121	26.3067	6.22	Yes	No	0	8	7
56	R:R:F117	R:R:G206	12.2123	3.01	Yes	No	0	8	5
57	R:R:F211	R:R:W251	43.3015	6.01	Yes	Yes	0	7	9
58	R:R:F211	R:R:F214	35.0941	4.29	Yes	Yes	0	7	8
59	R:R:F214	R:R:Y218	30.3548	11.35	Yes	Yes	0	8	9
60	R:R:S128	R:R:Y218	13.8661	5.09	No	Yes	0	9	9
61	R:R:C217	R:R:S128	12.1753	5.16	No	No	0	7	9
62	R:R:V240	R:R:Y218	22.1351	7.57	No	Yes	0	7	9
63	R:R:L222	R:R:V240	20.506	5.96	No	No	0	5	7
64	R:R:I237	R:R:L222	17.2107	5.71	Yes	No	0	7	5
65	R:R:I237	R:R:L225	10.4721	4.28	Yes	No	0	7	8
66	R:R:I69	R:R:R145	11.5828	8.77	Yes	Yes	2	6	7
67	R:R:A141	R:R:R145	16.9022	2.77	No	Yes	0	6	7
68	R:R:A141	R:R:L133	13.5452	1.58	No	No	0	6	5
69	R:R:L133	R:R:V144	10.1759	1.49	No	No	0	5	4
70	R:R:S185	R:R:Y172	16.9886	7.63	No	Yes	0	4	4
71	R:R:S185	R:R:Y187	15.1496	7.63	No	Yes	0	4	5
72	R:R:E177	R:R:Q182	15.0694	8.92	No	No	0	1	4
73	R:R:E177	R:R:Y184	12.9528	12.35	No	No	0	1	2
74	L:L:?1	R:R:L258	17.0071	5.68	Yes	No	0	0	5
75	R:R:L258	R:R:N199	15.0262	6.87	No	No	0	5	5
76	R:R:N199	R:R:S262	12.9158	8.94	No	No	0	5	5
77	R:R:F200	R:R:S262	10.793	6.61	No	No	0	5	5
78	L:L:?1	R:R:V257	46.2326	4.37	Yes	Yes	0	0	5
79	R:R:T285	R:R:V257	12.9158	6.35	No	Yes	0	6	5
80	R:R:T261	R:R:V257	30.8732	1.59	No	Yes	0	4	5
81	R:R:S265	R:R:T261	22.9374	1.6	No	No	0	3	4
82	R:R:H264	R:R:S265	12.706	1.39	No	No	0	2	3
83	R:R:R131	R:R:Y218	15.7606	9.26	No	Yes	0	9	9
84	R:R:R131	R:R:Y300	15.9642	7.2	No	Yes	0	9	9
85	R:R:F117	R:R:Y118	17.76	15.47	Yes	Yes	6	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y42	4.13	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q91	28.11	1	Yes	No	0	6	0	1
L:L:?1	R:R:V109	7.86	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y113	15.13	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y172	8.94	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F254	11.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:V257	4.37	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L258	5.68	1	Yes	No	0	5	0	1
L:L:?1	R:R:T282	6.92	1	Yes	No	0	4	0	1
L:L:?1	R:R:E286	24.87	1	Yes	No	0	5	0	1
R:R:L38	R:R:Y42	5.86	0	No	Yes	6	7	2	1
R:R:F290	R:R:Y42	7.22	1	Yes	Yes	7	7	2	1
R:R:F84	R:R:Y113	15.47	1	Yes	Yes	6	6	2	1
R:R:F290	R:R:F84	6.43	1	Yes	Yes	7	6	2	2
R:R:F90	R:R:V109	5.24	0	No	No	6	5	2	1
R:R:Q91	R:R:Y94	7.89	0	No	No	6	5	1	2
R:R:S110	R:R:Y172	13.99	0	No	Yes	5	4	2	1
R:R:Y113	R:R:Y114	5.96	1	Yes	Yes	6	5	1	2
R:R:E286	R:R:Y113	5.61	1	No	Yes	5	6	1	1
R:R:Y114	R:R:Y172	7.94	0	Yes	Yes	5	4	2	1
R:R:S185	R:R:Y172	7.63	0	No	Yes	4	4	2	1
R:R:L258	R:R:N199	6.87	0	No	No	5	5	1	2
R:R:F254	R:R:W251	6.01	1	No	Yes	7	9	1	2
R:R:S289	R:R:W251	6.18	1	No	Yes	8	9	2	2
R:R:F254	R:R:S289	14.53	1	No	No	7	8	1	2
R:R:T285	R:R:V257	6.35	0	No	Yes	6	5	2	1
R:R:E286	R:R:F290	9.33	1	No	Yes	5	7	1	2
R:R:L95	R:R:Q91	3.99	0	No	No	5	6	2	1
R:R:T92	R:R:Y42	3.75	0	No	Yes	7	7	2	1
R:R:A281	R:R:V257	3.39	0	No	Yes	5	5	2	1
R:R:T261	R:R:V257	1.59	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8KFX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4
Number of Linked Nodes	268
Number of Links	281
Number of Hubs	31
Number of Links mediated by Hubs	118
Number of Communities	6
Number of Nodes involved in Communities	30
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	43908
Length Of Smallest Path	3
Average Path Length	12.1071
Length of Longest Path	27
Minimum Path Strength	1.38
Average Path Strength	7.34587
Maximum Path Strength	21.62
Minimum Path Correlation	0.7
Average Path Correlation	0.92751
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	54.2486
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2843
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • coreceptor activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • chemokine binding • cytokine binding • chemotaxis • taxis • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell chemotaxis • cell migration • cell motility • immune response • immune system process • cell adhesion • calcium-mediated signaling • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OS9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OS9
Name	8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one
Synonyms	LMD-009
Identifier
Formula	C29 H33 N3 O3
Molecular Weight	471.591
SMILES
PubChem	91032188
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	0
Total Bonds	72
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51685
Sequence	>8KFX_nogp_Chain_R I Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C K K L R S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D Q W V F G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H A V Y A L K V R T I R M G T T L C L A V W L T A I M A T I P L L V F Y Q V A S E D G V L Q C Y S F Y N Q Q T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C Q N H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I L D G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K F K K H L S E I F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TLM	A	Protein	Chemokine	CCR8	Homo sapiens	Anti-murine CCR8 antibody	-	-	3.9	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-	Gi1/β1/γ2	3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-		3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8KFX	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-	Gi1/β1/γ2	2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFX (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-		2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-	Gi1/β1/γ2	3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-		3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8XML	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	2.58	2025-01-01	To be published
	8XML (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		2.58	2025-01-01	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KFX_nogp.zip

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