Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.4865222
2A:A:V34 5.07495
3A:A:L37 5.635409
4A:A:K46 6.2554239
5A:A:M53 4.4675498
6A:A:I184 5.285449
7A:A:F196 8.836597
8A:A:M198 4.1475497
9A:A:F199 8.90333645
10A:A:Q204 4.9419
11A:A:K210 5.82714719
12A:A:W211 5.7675409
13A:A:F215 6.4975449
14A:A:F223 6.03509
15A:A:V225 4.4407
16A:A:Y230 5.725658
17A:A:F250 5.9185179
18A:A:C254 4.554175
19A:A:W258 7.698505
20A:A:F259 7.26754159
21A:A:I265 3.6725408
22A:A:F267 5.135169
23A:A:L268 6.405408
24A:A:F274 6.605459
25A:A:L283 5.5765107
26A:A:C286 4.285406
27A:A:Y287 7.4045107
28A:A:Y290 10.884107
29A:A:Y296 5.25554
30A:A:Y302 10.5354106
31A:A:N311 6.79754178
32A:A:T316 4.9725403
33A:A:Y320 8.555407
34A:A:H322 7.634169
35A:A:F323 5.69454
36A:A:T324 7.0785169
37A:A:D328 6.14169
38A:A:N331 9.44254168
39A:A:F336 6.7225198
40A:A:I343 1.855407
41A:A:F354 8.0354265
42B:B:L7 3.4854278
43B:B:L14 3.4945138
44B:B:I18 4.3725417
45B:B:R22 7.7425416
46B:B:I37 4.9175482
47B:B:V40 4.71483
48B:B:R48 5.714537
49B:B:H54 8.70857739
50B:B:Y59 10.07548
51B:B:W63 6.988507
52B:B:V71 3.912508
53B:B:D76 5.846539
54B:B:L79 6.194207
55B:B:W82 9.54571739
56B:B:K89 6.82639
57B:B:I93 7.4625407
58B:B:L95 4.665208
59B:B:W99 7.69556949
60B:B:Y105 4.43606
61B:B:N110 5.48254214
62B:B:Y111 6.9954214
63B:B:C121 4.135418
64B:B:I123 3.36406
65B:B:Y124 5.545406
66B:B:T128 3.2525403
67B:B:H142 6.49619
68B:B:Y145 5.91143718
69B:B:F151 6.038509
70B:B:T159 5.1825419
71B:B:D163 6.33519
72B:B:C166 4.235468
73B:B:W169 7.76429718
74B:B:Q176 7.2275414
75B:B:F180 9.078567
76B:B:H183 8.29667669
77B:B:D186 9.0475419
78B:B:V187 4.426569
79B:B:F199 9.1575469
80B:B:S201 4.6075469
81B:B:C204 7.196517
82B:B:D205 6.018569
83B:B:K209 11.395466
84B:B:W211 8.57668
85B:B:Q220 6.4075417
86B:B:F222 7.475418
87B:B:H225 8.64571719
88B:B:D228 7.6425419
89B:B:I229 5.4975417
90B:B:I232 4.71418
91B:B:F234 5.06405
92B:B:F235 7.2825186
93B:B:P236 6.37754187
94B:B:F241 7.466516
95B:B:T243 6.6025418
96B:B:S245 6.2419
97B:B:D246 7.205419
98B:B:D247 7.59419
99B:B:T249 6.13416
100B:B:R251 10.26518
101B:B:F253 6.54857716
102B:B:D258 9.356517
103B:B:T263 6.5225411
104B:B:Y264 6.32167605
105B:B:F278 6.6485187
106B:B:R283 6.04689
107B:B:L285 5.445406
108B:B:L286 5.11477
109B:B:Y289 7.008336117
110B:B:D290 9.135406
111B:B:N295 7.3754116
112B:B:W297 5.9465118
113B:B:D298 6.69489
114B:B:L300 6.2575486
115B:B:K301 6.5125485
116B:B:H311 8.832579
117B:B:W332 12.3649
118B:B:D333 7.1325479
119B:B:L336 7.0475437
120B:B:K337 8.7325476
121B:B:I338 5.2975435
122B:B:W339 10.06579
123G:G:L19 2.83754139
124G:G:R27 7.766518
125G:G:Y40 9.32754186
126G:G:D48 5.822509
127G:G:N59 6.0275439
128G:G:P60 8.3725439
129G:G:F61 6.12167638
130R:R:F46 4.0525407
131R:R:N53 6.61409
132R:R:I57 3.724297
133R:R:I69 5.6625126
134R:R:Y73 6.043336127
135R:R:D81 7.0025429
136R:R:F84 6.425426
137R:R:F88 7.81427
138R:R:Y113 7.33333626
139R:R:Y118 5.212507
140R:R:M121 5.9425427
141R:R:F123 7.9825148
142R:R:R131 8.2425409
143R:R:Y132 6.1925308
144R:R:R145 7.54254127
145R:R:W158 7.064149
146R:R:L207 6.7975428
147R:R:P210 4.7275409
148R:R:F211 5.062527
149R:R:F214 6.93528
150R:R:C217 4.48407
151R:R:Y218 7.43833629
152R:R:K235 5.564267
153R:R:F250 7.31408
154R:R:W251 8.405629
155R:R:F254 6.946527
156R:R:F290 9.0225427
157R:R:C293 5.3375428
158R:R:N296 9.0425429
159R:R:Y300 6.19509
160R:R:F307 8.54408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 14.53984.56NoYes059
2B:B:L70 B:B:W63 14.8745.69NoYes057
3B:B:M61 B:B:W63 40.15924.65NoYes067
4B:B:C317 B:B:M61 40.77174.86NoNo076
5B:B:C317 B:B:S316 41.38273.44NoNo079
6B:B:S316 B:B:W332 41.68776.18NoYes099
7A:A:H213 B:B:W332 16.07137.41NoYes489
8A:A:H213 A:A:W258 16.34668.46NoYes085
9A:A:N256 A:A:W258 48.323.39NoYes085
10A:A:I212 A:A:N256 48.03555.66NoNo1588
11A:A:I212 A:A:R208 48.54915.01NoNo089
12A:A:L249 A:A:R208 1004.86NoNo099
13A:A:F223 A:A:L249 99.97217.31YesNo099
14A:A:F223 A:A:G40 93.17844.52YesNo099
15A:A:G40 A:A:S44 93.08771.86NoNo099
16A:A:G45 A:A:S44 92.99731.86NoNo099
17A:A:G45 A:A:N269 92.90843.39NoNo099
18A:A:N269 A:A:T324 92.82078.77NoYes099
19A:A:F267 A:A:T324 91.81916.49YesYes1699
20A:A:F267 A:A:I265 92.31033.77YesYes098
21A:A:I222 A:A:I265 90.80294.42NoYes078
22A:A:I222 A:A:L36 88.88774.28NoNo077
23A:A:F196 A:A:L36 88.78736.09YesNo077
24A:A:F196 A:A:V34 88.10629.18YesYes975
25A:A:I343 A:A:V34 90.5021.54YesYes075
26B:B:R314 B:B:W332 21.485815.99NoYes089
27A:A:W258 B:B:R314 31.63974YesNo058
28A:A:F215 B:B:W99 10.20229.02YesYes499
29A:A:L266 A:A:L268 13.05265.54NoYes098
30A:A:F223 A:A:L266 14.06923.65YesNo099
31A:A:F223 A:A:F250 20.39899.65YesYes099
32A:A:F215 A:A:W211 10.80664.01YesYes099
33A:A:Q204 A:A:W211 61.2725.48YesYes099
34A:A:Q204 B:B:Y145 60.71254.51YesYes198
35A:A:K210 B:B:Y145 35.68443.58YesYes198
36A:A:K210 B:B:D228 17.60756.91YesYes199
37A:A:K210 B:B:D246 17.60844.15YesYes199
38A:A:M247 A:A:Y287 12.20958.38NoYes067
39A:A:I343 A:A:N347 89.49842.83YesNo078
40A:A:N347 R:R:A134 89.3854.69NoNo088
41R:R:A134 R:R:R145 89.27136.91NoYes087
42R:R:I69 R:R:R145 51.05135.01YesYes1267
43R:R:I69 R:R:S68 13.47073.1YesNo067
44R:R:I69 R:R:Y73 38.41449.67YesYes1267
45R:R:M127 R:R:Y73 70.74174.79NoYes097
46R:R:M127 R:R:Y300 70.36968.38NoYes099
47R:R:R131 R:R:Y300 14.91657.2YesYes099
48R:R:D130 R:R:R145 37.991315.48NoYes1287
49R:R:D130 R:R:Y73 37.82896.9NoYes1287
50B:B:D290 B:B:R314 20.95722.63YesNo068
51B:B:D290 B:B:T274 11.99154.34YesNo068
52B:B:S275 B:B:T274 11.83283.2NoNo088
53B:B:L318 B:B:S275 11.67586.01NoNo068
54B:B:F234 B:B:V200 11.31229.18YesNo056
55B:B:D258 B:B:F222 23.40963.58YesYes178
56B:B:D258 B:B:R22 13.156914.29YesYes176
57B:B:I18 G:G:A23 18.23283.25YesNo078
58B:B:Q17 G:G:A23 17.53611.52NoNo048
59B:B:L14 B:B:Q17 16.13755.32YesNo1384
60B:B:M325 G:G:P60 15.396510.06NoYes059
61B:B:M325 G:G:P49 13.77378.39NoNo057
62G:G:D48 G:G:P49 13.0994.83YesNo097
63G:G:D48 G:G:L51 11.4066.79YesNo096
64B:B:R283 G:G:L51 10.72614.86YesNo096
65B:B:C271 B:B:D290 12.50656.22NoYes056
66B:B:C271 B:B:Y289 11.43814.03NoYes1157
67B:B:G162 B:B:Y145 29.04625.79NoYes198
68B:B:G162 B:B:S161 30.17263.71NoNo199
69B:B:H142 B:B:S161 28.460315.34YesNo199
70B:B:H142 B:B:T159 12.8765.48YesYes199
71B:B:C149 B:B:T159 14.29353.38NoYes189
72B:B:C149 B:B:T102 14.18646.76NoNo088
73B:B:C148 B:B:T102 14.02783.38NoNo068
74B:B:S84 B:B:W63 23.78764.94NoYes057
75B:B:S84 G:G:F61 22.14345.28NoYes358
76B:B:H142 B:B:W169 14.60644.23YesYes198
77B:B:I157 B:B:W169 15.53033.52NoYes078
78B:B:D228 B:B:S227 18.87435.89YesNo196
79B:B:S227 B:B:S245 36.03353.26NoYes169
80B:B:D246 B:B:S227 17.51565.89YesNo196
81B:B:H225 B:B:S245 29.951312.55YesYes199
82R:R:D81 R:R:N53 14.45388.08YesYes099
83R:R:N53 R:R:S49 11.04894.47YesNo098
84R:R:N296 R:R:Y300 34.72665.81YesYes099
85R:R:C293 R:R:N296 12.07953.15YesYes289
86R:R:C293 R:R:F84 11.30296.98YesYes286
87R:R:H292 R:R:N296 14.906619.13NoYes099
88R:R:H292 R:R:W251 12.070222.22NoYes099
89R:R:I124 R:R:Y300 14.54596.04NoYes089
90R:R:F214 R:R:I124 14.13595.02YesNo088
91R:R:R131 R:R:Y218 18.12888.23YesYes099
92R:R:C217 R:R:S128 15.56475.16YesNo079
93R:R:C217 R:R:Y132 11.42229.41YesYes078
94G:G:F61 G:G:P60 17.24365.78YesYes389
95A:A:R208 A:A:W211 57.13485NoYes099
96B:B:F253 B:B:H225 25.27994.53YesYes169
97B:B:F222 B:B:F253 21.871910.72YesYes186
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XML
Class A
SubFamily Protein
Type Chemokine
SubType CCR8
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.58
Date 2025-01-01
D.O.I. To be published
Net Summary
Imin 3
Number of Linked Nodes 786
Number of Links 958
Number of Hubs 160
Number of Links mediated by Hubs 580
Number of Communities 30
Number of Nodes involved in Communities 238
Number of Links involved in Communities 343
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 889928
Length Of Smallest Path 3
Average Path Length 29.7612
Length of Longest Path 58
Minimum Path Strength 1.33
Average Path Strength 5.93734
Maximum Path Strength 21.3833
Minimum Path Correlation 0.7
Average Path Correlation 0.976965
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 44.0199
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.4547
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • chemokine binding   • cytokine binding   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • chemotaxis   • taxis   • response to external stimulus   • locomotion   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell chemotaxis   • cell migration   • cell motility   • immune response   • immune system process   • cell adhesion   • calcium-mediated signaling   • periplasmic space   • cell surface   • external side of plasma membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8XML_Chain_A
CTLKAAVER SKMIDRNLR EDGEKAARE VKLLLLGAG ESGKTIVKQ 
MKTGIVETH FTFKDLHFK MFDVQRSER KKWIHCFEG VTAIIFCVA 
LSDYDLMNR MHSMKLFDS ICNNKWFTD TSIILFLNK KDLFEEKIK 
KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD TKEIYTHFT 
CTDTKNVQF VFDAVTDVI IKNNLKDCG LFSAEDCTA AS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XML_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XML_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51685
Sequence
>8XML_Chain_R
VFYCLLFVF SLLGNSLVI LVLVVCKKL RSITDVYLL NLALSDLLF 
VFSFPFQTY YLLDQWVFG TVMCKVVSG FYYIGFYSS MFITLMSVD 
RYLAVVHAV YALKVRTIR MGTTLCLAV WLTAIMATI PLCYTNFKM 
NILGLLIPF TIFMFCYIK ILHQLKRCQ NHNKTKAIR LVLIVVIAS 
LLFWVPFNV VLFLTSTEI ISFTHCCVN PVIYAFVGE KFKKHLW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TLMAProteinChemokineCCR8Homo sapiensAnti-murine CCR8 antibody--3.92023-12-20doi.org/10.1038/s41467-023-43601-8
8U1UAProteinChemokineCCR8Homo sapiensCCL1-Gi1/β1/γ23.12023-12-20doi.org/10.1038/s41467-023-43601-8
8U1U (No Gprot) AProteinChemokineCCR8Homo sapiensCCL1-3.12023-12-20doi.org/10.1038/s41467-023-43601-8
8KFXAProteinChemokineCCR8Homo sapiensLMD-009-Gi1/β1/γ22.962024-02-07doi.org/10.1126/sciadv.adj7500
8KFX (No Gprot) AProteinChemokineCCR8Homo sapiensLMD-009-2.962024-02-07doi.org/10.1126/sciadv.adj7500
8KFYAProteinChemokineCCR8Homo sapiensZK-756326-Gi1/β1/γ23.062024-02-07doi.org/10.1126/sciadv.adj7500
8KFY (No Gprot) AProteinChemokineCCR8Homo sapiensZK-756326-3.062024-02-07doi.org/10.1126/sciadv.adj7500
8KFZAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ23.32024-02-07doi.org/10.1126/sciadv.adj7500
8KFZ (No Gprot) AProteinChemokineCCR8Homo sapiens--3.32024-02-07doi.org/10.1126/sciadv.adj7500
8XMLAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ22.582025-01-01To be published
8XML (No Gprot) AProteinChemokineCCR8Homo sapiens--2.582025-01-01To be published




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