psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I30	R:R:Y280	9.67	No	No	0	1	3
2	R:R:K35	R:R:Q31	5.42	No	No	4	4	2
3	R:R:Q31	R:R:Y280	11.27	No	No	0	2	3
4	R:R:H283	R:R:Q31	12.36	No	No	4	4	2
5	R:R:K35	R:R:L95	7.05	No	No	0	4	5
6	R:R:H283	R:R:K35	3.93	No	No	4	4	4
7	R:R:L38	R:R:Y42	5.86	No	Yes	0	6	7
8	R:R:T92	R:R:Y42	12.48	No	Yes	0	7	7
9	R:R:L95	R:R:Y42	3.52	No	Yes	0	5	7
10	R:R:I287	R:R:Y42	4.84	No	Yes	5	5	7
11	R:R:F290	R:R:Y42	9.28	Yes	Yes	5	7	7
12	R:R:F48	R:R:L44	3.65	No	No	0	5	5
13	R:R:C294	R:R:L45	4.76	No	No	0	7	7
14	R:R:F46	R:R:P89	14.45	No	No	0	7	8
15	R:R:N53	R:R:S49	5.96	No	No	0	9	8
16	R:R:C293	R:R:S49	5.16	No	No	0	8	8
17	R:R:C294	R:R:S49	6.89	No	No	0	7	8
18	R:R:D81	R:R:N53	6.73	No	No	6	9	9
19	R:R:N53	R:R:P297	4.89	No	No	6	9	9
20	R:R:F302	R:R:L55	4.87	Yes	No	0	6	6
21	R:R:F302	R:R:V56	3.93	Yes	No	7	6	9
22	R:R:F307	R:R:V56	5.24	Yes	No	7	8	9
23	R:R:I57	R:R:L75	4.28	No	Yes	0	7	6
24	R:R:L58	R:R:V62	7.45	No	No	0	3	5
25	R:R:F307	R:R:V59	9.18	Yes	No	0	8	7
26	R:R:I314	R:R:V59	4.61	No	No	0	4	7
27	R:R:D71	R:R:L60	4.07	No	No	0	8	7
28	R:R:L60	R:R:L75	5.54	No	Yes	0	7	6
29	R:R:L75	R:R:V61	4.47	Yes	No	0	6	4
30	R:R:C63	R:R:I314	6.55	No	No	0	5	4
31	R:R:K64	R:R:R67	11.14	Yes	No	8	5	6
32	R:R:H310	R:R:K64	13.1	No	Yes	8	4	5
33	R:R:E313	R:R:K64	8.1	No	Yes	0	5	5
34	R:R:K317	R:R:K64	5.75	No	Yes	0	4	5
35	R:R:K65	R:R:R67	17.33	No	No	0	6	6
36	R:R:L66	R:R:V72	7.45	No	No	0	6	6
37	R:R:L66	R:R:L75	6.92	No	Yes	0	6	6
38	R:R:H310	R:R:R67	4.51	No	No	8	4	6
39	R:R:S68	R:R:T70	6.4	No	No	0	7	8
40	R:R:D71	R:R:S68	11.78	No	No	0	8	7
41	R:R:L126	R:R:Y73	14.07	No	Yes	9	7	7
42	R:R:M127	R:R:Y73	5.99	No	Yes	0	9	7
43	R:R:D130	R:R:Y73	6.9	No	Yes	0	8	7
44	R:R:G150	R:R:Y73	4.35	No	Yes	0	7	7
45	R:R:L153	R:R:Y73	4.69	No	Yes	9	6	7
46	R:R:A301	R:R:L74	4.73	No	No	0	7	8
47	R:R:L79	R:R:N76	4.12	No	Yes	0	6	9
48	R:R:F123	R:R:N76	7.25	Yes	Yes	10	8	9
49	R:R:C154	R:R:N76	6.3	No	Yes	0	7	9
50	R:R:N76	R:R:W158	5.65	Yes	No	10	9	9
51	R:R:D81	R:R:L77	6.79	No	No	0	9	9
52	R:R:S119	R:R:S80	6.52	No	No	0	7	8
53	R:R:F123	R:R:S80	3.96	Yes	No	0	8	8
54	R:R:D81	R:R:P297	6.44	No	No	6	9	9
55	R:R:F86	R:R:L82	6.09	No	No	0	4	7
56	R:R:F86	R:R:L83	6.09	No	No	0	4	6
57	R:R:I115	R:R:L83	8.56	No	No	0	5	6
58	R:R:F84	R:R:F88	7.5	Yes	Yes	0	6	7
59	R:R:F84	R:R:Y113	16.5	Yes	No	0	6	6
60	R:R:F84	R:R:G116	4.52	Yes	No	0	6	8
61	R:R:F84	R:R:H292	7.92	Yes	No	0	6	9
62	R:R:F88	R:R:V85	3.93	Yes	No	0	7	6
63	R:R:F112	R:R:F86	16.08	No	No	0	5	4
64	R:R:Q91	R:R:S87	5.78	No	No	0	6	7
65	R:R:S87	R:R:Y113	8.9	No	No	0	7	6
66	R:R:F290	R:R:F88	11.79	Yes	Yes	0	7	7
67	R:R:C293	R:R:F88	6.98	No	Yes	0	8	7
68	R:R:F90	R:R:V109	13.11	No	No	0	6	5
69	R:R:D97	R:R:Y93	8.05	No	No	0	4	2
70	R:R:V100	R:R:Y93	8.83	No	No	0	3	2
71	R:R:F101	R:R:Y93	8.25	No	No	0	7	2
72	R:R:W99	R:R:Y94	3.86	Yes	No	0	9	5
73	R:R:Q182	R:R:Y94	9.02	No	No	0	4	5
74	R:R:D97	R:R:Q98	3.92	No	No	0	4	4
75	R:R:L181	R:R:Q98	6.65	No	No	0	4	4
76	R:R:F101	R:R:W99	18.04	No	Yes	0	7	9
77	R:R:C106	R:R:W99	5.22	Yes	Yes	12	9	9
78	R:R:V109	R:R:W99	6.13	No	Yes	0	5	9
79	R:R:C183	R:R:W99	9.14	No	Yes	12	9	9
80	R:R:T103	R:R:V174	6.35	No	No	0	2	5
81	R:R:M105	R:R:V104	6.09	No	No	0	6	4
82	R:R:C106	R:R:Y172	4.03	Yes	Yes	0	9	4
83	R:R:C106	R:R:C183	7.28	Yes	No	12	9	9
84	R:R:F112	R:R:V108	3.93	No	No	0	5	5
85	R:R:G111	R:R:S110	3.71	No	No	0	5	5
86	R:R:S110	R:R:Y172	16.53	No	Yes	0	5	4
87	R:R:Y114	R:R:Y118	5.96	Yes	Yes	1	5	7
88	R:R:T165	R:R:Y114	3.75	Yes	Yes	1	7	5
89	R:R:L168	R:R:Y114	22.27	Yes	Yes	1	4	5
90	R:R:Y114	R:R:Y172	8.94	Yes	Yes	0	5	4
91	R:R:M202	R:R:Y114	3.59	Yes	Yes	1	5	5
92	R:R:I115	R:R:T165	6.08	No	Yes	0	5	7
93	R:R:G116	R:R:S119	3.71	No	No	0	8	7
94	R:R:F117	R:R:Y118	9.28	Yes	Yes	0	8	7
95	R:R:F117	R:R:M121	14.93	Yes	No	0	8	7
96	R:R:F117	R:R:M202	4.98	Yes	Yes	0	8	5
97	R:R:F117	R:R:F254	6.43	Yes	No	0	8	7
98	R:R:A164	R:R:Y118	9.34	No	Yes	0	5	7
99	R:R:T165	R:R:Y118	6.24	Yes	Yes	1	7	7
100	R:R:L168	R:R:Y118	3.52	Yes	Yes	1	4	7
101	R:R:S120	R:R:W251	3.71	No	Yes	11	9	9
102	R:R:H292	R:R:S120	6.97	No	No	11	9	9
103	R:R:M121	R:R:W251	8.14	No	Yes	0	7	9
104	R:R:F122	R:R:V157	5.24	No	No	0	5	6
105	R:R:F122	R:R:T160	5.19	No	No	0	5	4
106	R:R:F123	R:R:V157	7.87	Yes	No	0	8	6
107	R:R:F123	R:R:W158	8.02	Yes	No	10	8	9
108	R:R:F214	R:R:I124	3.77	Yes	No	0	8	8
109	R:R:I124	R:R:W251	3.52	No	Yes	0	8	9
110	R:R:I124	R:R:Y300	7.25	No	Yes	0	8	9
111	R:R:P210	R:R:T125	6.99	No	No	0	9	7
112	R:R:L126	R:R:L153	9.69	No	No	9	7	6
113	R:R:M127	R:R:Y300	9.58	No	Yes	0	9	9
114	R:R:F214	R:R:S128	5.28	Yes	No	2	8	9
115	R:R:C217	R:R:S128	5.16	Yes	No	0	7	9
116	R:R:S128	R:R:Y218	7.63	No	Yes	2	9	9
117	R:R:D130	R:R:R145	16.68	No	No	0	8	7
118	R:R:R131	R:R:Y218	8.23	No	Yes	2	9	9
119	R:R:R131	R:R:Y300	14.4	No	Yes	2	9	9
120	R:R:V136	R:R:Y132	13.88	Yes	Yes	3	7	8
121	R:R:H137	R:R:Y132	7.62	No	Yes	3	6	8
122	R:R:F216	R:R:Y132	6.19	No	Yes	3	4	8
123	R:R:C217	R:R:Y132	8.06	Yes	Yes	0	7	8
124	R:R:K220	R:R:Y132	9.55	No	Yes	3	4	8
125	R:R:A134	R:R:R145	5.53	No	No	0	8	7
126	R:R:I221	R:R:V135	7.68	No	No	0	8	8
127	R:R:H137	R:R:V136	11.07	No	Yes	3	6	7
128	R:R:K220	R:R:V136	4.55	No	Yes	3	4	7
129	R:R:Q224	R:R:V136	5.73	No	Yes	0	5	7
130	R:R:K143	R:R:Y140	4.78	No	No	0	5	4
131	R:R:V144	R:R:Y140	8.83	No	No	0	4	4
132	R:R:L153	R:R:M149	4.24	No	No	0	6	3
133	R:R:L169	R:R:T165	4.42	No	Yes	0	4	7
134	R:R:F171	R:R:L168	3.65	No	Yes	0	4	4
135	R:R:L168	R:R:T198	5.9	Yes	No	0	4	6
136	R:R:F171	R:R:Y187	9.28	No	Yes	0	4	5
137	R:R:S185	R:R:Y172	8.9	No	Yes	0	4	4
138	R:R:F186	R:R:Q173	14.05	No	No	0	4	4
139	R:R:A175	R:R:Y184	4	No	No	0	1	2
140	R:R:E177	R:R:Q182	10.19	No	No	0	1	4
141	R:R:E177	R:R:Y184	4.49	No	No	0	1	2
142	R:R:F186	R:R:Y184	7.22	No	No	0	4	2
143	R:R:S185	R:R:Y187	10.17	No	Yes	0	4	5
144	R:R:T191	R:R:Y187	7.49	No	Yes	0	3	5
145	R:R:K195	R:R:Y187	19.11	Yes	Yes	0	5	5
146	R:R:T198	R:R:Y187	3.75	No	Yes	0	6	5
147	R:R:L192	R:R:Q189	3.99	No	No	0	1	4
148	R:R:K193	R:R:W194	12.76	No	No	0	2	2
149	R:R:F197	R:R:W194	5.01	No	No	0	4	2
150	R:R:K195	R:R:N199	5.6	Yes	Yes	0	5	5
151	R:R:K201	R:R:T198	7.51	No	No	0	4	6
152	R:R:M202	R:R:N199	4.21	Yes	Yes	1	5	5
153	R:R:L258	R:R:N199	4.12	No	Yes	1	5	5
154	R:R:N199	R:R:S262	4.47	Yes	No	0	5	5
155	R:R:F200	R:R:N203	3.62	No	Yes	13	5	6
156	R:R:F200	R:R:F259	6.43	No	Yes	13	5	6
157	R:R:F200	R:R:S262	6.61	No	No	0	5	5
158	R:R:L258	R:R:M202	4.24	No	Yes	1	5	5
159	R:R:L208	R:R:N203	6.87	No	Yes	0	4	6
160	R:R:N203	R:R:N255	4.09	Yes	Yes	0	6	8
161	R:R:F259	R:R:N203	3.62	Yes	Yes	13	6	6
162	R:R:F211	R:R:L207	17.05	No	No	0	7	8
163	R:R:L207	R:R:N255	12.36	No	Yes	0	8	8
164	R:R:F211	R:R:W251	9.02	No	Yes	0	7	9
165	R:R:F214	R:R:Y218	16.5	Yes	Yes	2	8	9
166	R:R:F214	R:R:V244	3.93	Yes	No	0	8	8
167	R:R:F214	R:R:S247	7.93	Yes	No	0	8	9
168	R:R:F216	R:R:K220	4.96	No	No	3	4	4
169	R:R:I221	R:R:Y218	3.63	No	Yes	0	8	9
170	R:R:V240	R:R:Y218	3.79	No	Yes	0	7	9
171	R:R:V243	R:R:Y218	3.79	No	Yes	2	8	9
172	R:R:Y218	R:R:Y300	5.96	Yes	Yes	2	9	9
173	R:R:L222	R:R:L241	4.15	No	No	14	5	5
174	R:R:Q224	R:R:R227	4.67	No	No	0	5	5
175	R:R:I237	R:R:L225	5.71	Yes	No	0	7	8
176	R:R:I237	R:R:K226	4.36	Yes	No	0	7	4
177	R:R:C228	R:R:N230	4.72	No	No	0	6	4
178	R:R:K235	R:R:R238	4.95	No	No	0	7	6
179	R:R:K235	R:R:L239	7.05	No	No	0	7	8
180	R:R:L239	R:R:V303	7.45	No	No	0	8	7
181	R:R:V243	R:R:Y300	5.05	No	Yes	2	8	9
182	R:R:A246	R:R:F250	4.16	No	Yes	0	6	8
183	R:R:F250	R:R:W251	7.02	Yes	Yes	0	8	9
184	R:R:F250	R:R:V295	13.11	Yes	No	0	8	6
185	R:R:H292	R:R:W251	12.7	No	Yes	11	9	9
186	R:R:P253	R:R:V252	5.3	No	No	0	9	5
187	R:R:N255	R:R:V252	5.91	Yes	No	0	8	5
188	R:R:I288	R:R:P253	5.08	No	No	0	7	9
189	R:R:F254	R:R:S289	9.25	No	No	0	7	8
190	R:R:N255	R:R:V256	5.91	Yes	No	0	8	6
191	R:R:T285	R:R:V257	12.69	No	No	0	6	5
192	R:R:F259	R:R:L260	4.87	Yes	No	0	6	4
193	R:R:F259	R:R:L263	9.74	Yes	No	0	6	4
194	R:R:L263	R:R:L269	4.15	No	No	0	4	2
195	R:R:D270	R:R:H264	8.82	No	Yes	0	1	2
196	R:R:H264	R:R:I274	3.98	Yes	No	0	2	3
197	R:R:H264	R:R:L278	5.14	Yes	No	0	2	5
198	R:R:I268	R:R:M266	4.37	No	No	0	1	3
199	R:R:D270	R:R:H267	15.13	No	No	0	1	1
200	R:R:G271	R:R:I274	5.29	No	No	0	3	3
201	R:R:E286	R:R:F290	4.66	No	Yes	0	5	7
202	R:R:F290	R:R:I287	3.77	Yes	No	5	7	5
203	R:R:F290	R:R:S289	3.96	Yes	No	0	7	8
204	R:R:N296	R:R:Y300	4.65	No	Yes	0	9	9
205	R:R:F302	R:R:V298	7.87	Yes	No	0	6	6
206	R:R:A301	R:R:F307	4.16	No	Yes	0	7	8
207	R:R:F302	R:R:F307	7.5	Yes	Yes	7	6	8
208	R:R:E305	R:R:K309	6.75	No	No	0	4	5
209	R:R:H310	R:R:K306	3.93	No	No	0	4	6
210	R:R:F307	R:R:L311	4.87	Yes	No	0	8	6
211	R:R:E313	R:R:K309	5.4	No	No	0	5	5
212	R:R:G34	R:R:L37	3.42	No	No	0	4	5
213	R:R:C106	R:R:V174	3.42	Yes	No	0	9	5
214	R:R:A78	R:R:V56	3.39	No	No	0	9	9
215	R:R:I166	R:R:P167	3.39	No	No	0	4	8
216	R:R:I209	R:R:P210	3.39	No	No	0	6	9
217	R:R:A78	R:R:I57	3.25	No	No	0	9	7
218	R:R:C63	R:R:K64	3.23	No	Yes	0	5	5
219	R:R:I196	R:R:S265	3.1	No	No	0	3	3
220	R:R:I299	R:R:V295	3.07	No	No	0	8	6
221	R:R:I299	R:R:V298	3.07	No	No	0	8	6
222	R:R:K195	R:R:S265	3.06	Yes	No	0	5	3
223	R:R:I213	R:R:T125	3.04	No	No	0	7	7
224	R:R:F302	R:R:G52	3.01	Yes	No	0	6	8
225	R:R:M149	R:R:T152	3.01	No	No	0	3	3
226	R:R:L50	R:R:S54	3	No	No	0	6	4
227	R:R:L181	R:R:S176	3	No	No	0	4	3
228	R:R:K233	R:R:T234	3	No	No	0	6	4
229	R:R:L222	R:R:V240	2.98	No	No	0	5	7
230	R:R:L248	R:R:V252	2.98	No	No	0	6	5
231	R:R:L96	R:R:T92	2.95	No	No	0	4	7
232	R:R:I162	R:R:I166	2.94	No	No	0	3	4
233	R:R:N188	R:R:T191	2.92	No	No	0	3	3
234	R:R:I196	R:R:M266	2.92	No	No	0	3	3
235	R:R:I219	R:R:M215	2.92	No	No	0	4	4
236	R:R:I237	R:R:K233	2.91	Yes	No	0	7	6
237	R:R:F90	R:R:P89	2.89	No	No	0	6	8
238	R:R:Q277	R:R:S273	2.89	No	No	0	3	1
239	R:R:Q182	R:R:V180	2.87	No	No	0	4	3
240	R:R:I166	R:R:L169	2.85	No	No	0	4	4
241	R:R:I204	R:R:L208	2.85	No	No	0	5	4
242	R:R:I237	R:R:L222	2.85	Yes	No	14	7	5
243	R:R:I237	R:R:L241	2.85	Yes	No	14	7	5
244	R:R:K195	R:R:L192	2.82	Yes	No	0	5	1
245	R:R:K201	R:R:L205	2.82	No	No	0	4	5
246	R:R:E286	R:R:T282	2.82	No	No	0	5	4
247	R:R:G102	R:R:W99	2.81	No	Yes	0	8	9
248	R:R:D130	R:R:I69	2.8	No	No	0	8	6
249	R:R:K233	R:R:N230	2.8	No	No	0	6	4
250	R:R:H264	R:R:S275	2.79	Yes	No	0	2	1
251	R:R:L155	R:R:L159	2.77	No	No	0	4	4
252	R:R:H283	R:R:T279	2.74	No	No	0	4	4
253	R:R:A161	R:R:Y118	2.67	No	Yes	0	8	7
254	R:R:F250	R:R:T291	2.59	Yes	No	0	8	5
255	R:R:F101	R:R:M105	2.49	No	No	0	7	6
256	R:R:F214	R:R:M215	2.49	Yes	No	0	8	4
257	R:R:K107	R:R:Y172	2.39	No	Yes	0	7	4
258	R:R:G179	R:R:S176	1.86	No	No	0	4	3
259	R:R:P253	R:R:T285	1.75	No	No	0	9	6
260	R:R:G304	R:R:K306	1.74	No	No	0	8	6
261	R:R:C272	R:R:S275	1.72	No	No	0	8	1
262	R:R:G52	R:R:L51	1.71	No	No	0	8	4
263	R:R:C217	R:R:V129	1.71	Yes	No	0	7	6
264	R:R:G206	R:R:L205	1.71	No	No	0	5	5
265	R:R:G34	R:R:N33	1.7	No	No	0	4	2
266	R:R:C217	R:R:I213	1.64	Yes	No	0	7	7
267	R:R:V61	R:R:V62	1.6	No	No	0	4	5
268	R:R:S265	R:R:T261	1.6	No	No	0	3	4
269	R:R:A39	R:R:L96	1.58	No	No	0	5	4
270	R:R:A141	R:R:L133	1.58	No	No	0	6	5
271	R:R:A236	R:R:L225	1.58	No	No	0	7	8
272	R:R:T151	R:R:T152	1.57	No	No	0	3	3
273	R:R:I274	R:R:S273	1.55	No	No	0	3	1
274	R:R:I147	R:R:V72	1.54	No	No	0	3	6
275	R:R:I245	R:R:V244	1.54	No	No	0	5	8
276	R:R:C272	R:R:Q276	1.53	No	No	0	8	3
277	R:R:M149	R:R:T146	1.51	No	No	0	3	7
278	R:R:L133	R:R:V144	1.49	No	No	0	5	4
279	R:R:I242	R:R:I299	1.47	No	No	0	5	8
280	R:R:L278	R:R:T261	1.47	No	No	0	5	4
281	R:R:I245	R:R:L249	1.43	No	No	0	5	6
282	R:R:K143	R:R:L142	1.41	No	No	0	5	4
283	R:R:L50	R:R:L82	1.38	No	No	0	6	7
284	R:R:A141	R:R:R145	1.38	No	No	0	6	7
285	R:R:N188	R:R:Q190	1.32	No	No	0	3	4
286	R:R:F48	R:R:V47	1.31	No	No	0	5	6
287	R:R:F171	R:R:V170	1.31	No	No	0	4	3
288	R:R:R148	R:R:T146	1.29	No	No	0	4	7
289	R:R:R148	R:R:T151	1.29	No	No	0	4	3
290	R:R:H231	R:R:N232	1.28	No	No	0	3	5
291	R:R:I242	R:R:R238	1.25	No	No	0	5	6
292	R:R:F41	R:R:L37	1.22	No	No	0	4	5
293	R:R:F41	R:R:L38	1.22	No	No	0	4	6
294	R:R:T191	R:R:W194	1.21	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y42	7.196	5	5	7
2	R:R:K64	8.264	5	8	5
3	R:R:Y73	7.2	5	9	7
4	R:R:L75	5.3025	4	0	6
5	R:R:N76	5.83	4	10	9
6	R:R:F84	9.11	4	0	6
7	R:R:F88	7.55	4	0	7
8	R:R:W99	7.53333	6	12	9
9	R:R:C106	4.9875	4	12	9
10	R:R:Y114	8.902	5	1	5
11	R:R:F117	8.905	4	0	8
12	R:R:Y118	6.16833	6	1	7
13	R:R:F123	6.775	4	10	8
14	R:R:Y132	9.06	5	3	8
15	R:R:V136	8.8075	4	3	7
16	R:R:T165	5.1225	4	1	7
17	R:R:L168	8.835	4	1	4
18	R:R:Y172	8.158	5	0	4
19	R:R:Y187	9.96	5	0	5
20	R:R:K195	7.6475	4	0	5
21	R:R:N199	4.6	4	1	5
22	R:R:M202	4.255	4	1	5
23	R:R:N203	4.55	4	13	6
24	R:R:F214	6.65	6	2	8
25	R:R:C217	4.1425	4	0	7
26	R:R:Y218	7.07571	7	2	9
27	R:R:I237	3.736	5	14	7
28	R:R:F250	6.72	4	0	8
29	R:R:W251	7.35167	6	11	9
30	R:R:N255	7.0675	4	0	8
31	R:R:F259	6.165	4	13	6
32	R:R:H264	5.1825	4	0	2
33	R:R:F290	6.692	5	5	7
34	R:R:Y300	7.815	6	2	9
35	R:R:F302	5.436	5	7	6
36	R:R:F307	6.19	5	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L95	R:R:Y42	11.0111	3.52	No	Yes	0	5	7
2	R:R:F290	R:R:Y42	24.991	9.28	Yes	Yes	5	7	7
3	R:R:C293	R:R:S49	11.4844	5.16	No	No	0	8	8
4	R:R:C293	R:R:F88	13.0795	6.98	No	Yes	0	8	7
5	R:R:F290	R:R:F88	23.5143	11.79	Yes	Yes	0	7	7
6	R:R:C106	R:R:W99	53.3162	5.22	Yes	Yes	12	9	9
7	R:R:C106	R:R:Y172	61.523	4.03	Yes	Yes	0	9	4
8	R:R:Y114	R:R:Y172	66.4574	8.94	Yes	Yes	0	5	4
9	R:R:Y114	R:R:Y118	31.2169	5.96	Yes	Yes	1	5	7
10	R:R:F117	R:R:Y118	64.106	9.28	Yes	Yes	0	8	7
11	R:R:F117	R:R:F254	24.5073	6.43	Yes	No	0	8	7
12	R:R:F254	R:R:S289	23.3136	9.25	No	No	0	7	8
13	R:R:F290	R:R:S289	22.125	3.96	Yes	No	0	7	8
14	R:R:M202	R:R:Y114	36.9385	3.59	Yes	Yes	1	5	5
15	R:R:F117	R:R:M202	58.1991	4.98	Yes	Yes	0	8	5
16	R:R:F302	R:R:V298	51.5719	7.87	Yes	No	0	6	6
17	R:R:I299	R:R:V298	52.8788	3.07	No	No	0	8	6
18	R:R:I299	R:R:V295	60.4322	3.07	No	No	0	8	6
19	R:R:F250	R:R:V295	61.6671	13.11	Yes	No	0	8	6
20	R:R:F250	R:R:W251	65.31	7.02	Yes	Yes	0	8	9
21	R:R:H292	R:R:W251	43.4062	12.7	No	Yes	11	9	9
22	R:R:F84	R:R:H292	42.4543	7.92	Yes	No	0	6	9
23	R:R:F84	R:R:F88	23.468	7.5	Yes	Yes	0	6	7
24	R:R:F302	R:R:V56	21.0548	3.93	Yes	No	7	6	9
25	R:R:F302	R:R:F307	25.2483	7.5	Yes	Yes	7	6	8
26	R:R:A78	R:R:V56	20.8644	3.39	No	No	0	9	9
27	R:R:A78	R:R:I57	19.3208	3.25	No	No	0	9	7
28	R:R:I57	R:R:L75	17.7669	4.28	No	Yes	0	7	6
29	R:R:F307	R:R:V59	20.4785	9.18	Yes	No	0	8	7
30	R:R:I314	R:R:V59	19.0635	4.61	No	No	0	4	7
31	R:R:C63	R:R:I314	17.6177	6.55	No	No	0	5	4
32	R:R:C63	R:R:K64	16.0587	3.23	No	Yes	0	5	5
33	R:R:I124	R:R:W251	94.7775	3.52	No	Yes	0	8	9
34	R:R:I124	R:R:Y300	49.3491	7.25	No	Yes	0	8	9
35	R:R:M127	R:R:Y300	30.3782	9.58	No	Yes	0	9	9
36	R:R:M127	R:R:Y73	28.9529	5.99	No	Yes	0	9	7
37	R:R:D130	R:R:Y73	15.822	6.9	No	Yes	0	8	7
38	R:R:F84	R:R:G116	17.7669	4.52	Yes	No	0	6	8
39	R:R:G116	R:R:S119	16.2027	3.71	No	No	0	8	7
40	R:R:S119	R:R:S80	14.6282	6.52	No	No	0	7	8
41	R:R:F123	R:R:S80	13.0435	3.96	Yes	No	0	8	8
42	R:R:I115	R:R:L83	11.2683	8.56	No	No	0	5	6
43	R:R:I115	R:R:T165	12.8377	6.08	No	Yes	0	5	7
44	R:R:T165	R:R:Y118	13.7741	6.24	Yes	Yes	1	7	7
45	R:R:D97	R:R:Y93	11.6234	8.05	No	No	0	4	2
46	R:R:F101	R:R:Y93	16.1976	8.25	No	No	0	7	2
47	R:R:F101	R:R:W99	22.9946	18.04	No	Yes	0	7	9
48	R:R:W99	R:R:Y94	18.477	3.86	Yes	No	0	9	5
49	R:R:Q182	R:R:Y94	16.2027	9.02	No	No	0	4	5
50	R:R:L168	R:R:Y118	20.7101	3.52	Yes	Yes	1	4	7
51	R:R:F117	R:R:M121	99.9897	14.93	Yes	No	0	8	7
52	R:R:F214	R:R:I124	46.0664	3.77	Yes	No	0	8	8
53	R:R:F214	R:R:S128	18.6519	5.28	Yes	No	2	8	9
54	R:R:C217	R:R:S128	19.928	5.16	Yes	No	0	7	9
55	R:R:F214	R:R:Y218	19.4134	16.5	Yes	Yes	2	8	9
56	R:R:Y218	R:R:Y300	21.8575	5.96	Yes	Yes	2	9	9
57	R:R:D130	R:R:R145	12.7553	16.68	No	No	0	8	7
58	R:R:C217	R:R:Y132	10.9442	8.06	Yes	Yes	0	7	8
59	R:R:F171	R:R:L168	10.229	3.65	No	Yes	0	4	4
60	R:R:L168	R:R:T198	12.4157	5.9	Yes	No	0	4	6
61	R:R:M202	R:R:N199	32.5444	4.21	Yes	Yes	1	5	5
62	R:R:K195	R:R:N199	28.3561	5.6	Yes	Yes	0	5	5
63	R:R:K195	R:R:Y187	12.8891	19.11	Yes	Yes	0	5	5
64	R:R:E177	R:R:Q182	11.6234	10.19	No	No	0	1	4
65	R:R:T191	R:R:Y187	20.8335	7.49	No	Yes	0	3	5
66	R:R:T191	R:R:W194	10.4605	1.21	No	No	0	3	2
67	R:R:F211	R:R:W251	17.1495	9.02	No	Yes	0	7	9
68	R:R:F211	R:R:L207	15.6676	17.05	No	No	0	7	8
69	R:R:L207	R:R:N255	14.5356	12.36	No	Yes	0	8	8
70	R:R:N203	R:R:N255	10.4605	4.09	Yes	Yes	0	6	8
71	R:R:V240	R:R:Y218	30.9956	3.79	No	Yes	0	7	9
72	R:R:L222	R:R:V240	28.4487	2.98	No	No	0	5	7
73	R:R:I237	R:R:L222	22.7991	2.85	Yes	No	14	7	5
74	R:R:I237	R:R:K233	11.4999	2.91	Yes	No	0	7	6
75	R:R:H264	R:R:L278	14.2321	5.14	Yes	No	0	2	5
76	R:R:L278	R:R:T261	15.4515	1.47	No	No	0	5	4
77	R:R:S265	R:R:T261	16.815	1.6	No	No	0	3	4
78	R:R:K195	R:R:S265	21.9964	3.06	Yes	No	0	5	3
79	R:R:M121	R:R:W251	100	8.14	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8KFZ_nogp

PDB Summary
PDB	8KFZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	270
Number of Links	294
Number of Hubs	36
Number of Links mediated by Hubs	142
Number of Communities	14
Number of Nodes involved in Communities	51
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	46204
Length Of Smallest Path	3
Average Path Length	13.3358
Length of Longest Path	28
Minimum Path Strength	1.22
Average Path Strength	6.67753
Maximum Path Strength	15.9133
Minimum Path Correlation	0.7
Average Path Correlation	0.926988
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	49.9358
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8688
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51685
Sequence	>8KFZ_nogp_Chain_R I Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C K K L R S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D Q W V F G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H A V Y A L K V R T I R M G T T L C L A V W L T A I M A T I P L L V F Y Q V A S E D G V L Q C Y S F Y N Q Q T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C Q N H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I L D G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K F K K H L S E I F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TLM	A	Protein	Chemokine	CCR8	Homo sapiens	Anti-murine CCR8 antibody	-	-	3.9	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-	Gi1/β1/γ2	3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-		3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8KFX	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-	Gi1/β1/γ2	2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFX (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-		2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-	Gi1/β1/γ2	3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-		3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8XML	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	2.58	2025-01-01	To be published
	8XML (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		2.58	2025-01-01	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KFZ_nogp.zip

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