psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y42	6.34	Yes	Yes	1	0	7
2	L:L:?1	R:R:Q91	26.74	Yes	Yes	1	0	6
3	L:L:?1	R:R:W99	6.16	Yes	Yes	1	0	9
4	L:L:?1	R:R:Y113	18.12	Yes	Yes	1	0	6
5	L:L:?1	R:R:Y114	8.15	Yes	Yes	1	0	5
6	L:L:?1	R:R:Y172	9.96	Yes	No	1	0	4
7	L:L:?1	R:R:C183	3.68	Yes	No	1	0	9
8	L:L:?1	R:R:T198	4.56	Yes	No	0	0	6
9	L:L:?1	R:R:E286	12.29	Yes	No	0	0	5
10	R:R:L37	R:R:N33	6.87	No	No	0	5	2
11	R:R:G34	R:R:L37	5.13	No	No	0	4	5
12	R:R:K35	R:R:L95	4.23	No	No	0	4	5
13	R:R:K35	R:R:L96	4.23	No	No	0	4	4
14	R:R:L38	R:R:Y42	4.69	No	Yes	0	6	7
15	R:R:L38	R:R:L95	4.15	No	No	0	6	5
16	R:R:H283	R:R:L38	6.43	No	No	0	4	6
17	R:R:F41	R:R:I287	6.28	No	No	0	4	5
18	R:R:F88	R:R:Y42	6.19	Yes	Yes	1	7	7
19	R:R:Q91	R:R:Y42	7.89	Yes	Yes	1	6	7
20	R:R:F290	R:R:Y42	10.32	Yes	Yes	1	7	7
21	R:R:L45	R:R:T291	5.9	No	No	0	7	5
22	R:R:F46	R:R:L50	4.87	Yes	No	0	7	6
23	R:R:F46	R:R:V85	3.93	Yes	Yes	1	7	6
24	R:R:F46	R:R:F88	7.5	Yes	Yes	1	7	7
25	R:R:F46	R:R:P89	7.22	Yes	No	0	7	8
26	R:R:N53	R:R:S49	4.47	No	Yes	0	9	8
27	R:R:S49	R:R:V85	4.85	Yes	Yes	0	8	6
28	R:R:C293	R:R:S49	6.89	No	Yes	0	8	8
29	R:R:C294	R:R:S49	5.16	No	Yes	0	7	8
30	R:R:D81	R:R:N53	6.73	No	No	0	9	9
31	R:R:N53	R:R:P297	8.15	No	No	0	9	9
32	R:R:F302	R:R:L55	7.31	Yes	No	0	6	6
33	R:R:L311	R:R:L55	4.15	No	No	0	6	6
34	R:R:F302	R:R:V56	3.93	Yes	No	6	6	9
35	R:R:F307	R:R:V56	5.24	Yes	No	6	8	9
36	R:R:L58	R:R:V62	4.47	No	No	0	3	5
37	R:R:F307	R:R:V59	10.49	Yes	No	0	8	7
38	R:R:I314	R:R:V59	4.61	No	No	0	4	7
39	R:R:D71	R:R:L60	5.43	No	No	0	8	7
40	R:R:C63	R:R:I314	6.55	No	No	0	5	4
41	R:R:K64	R:R:R67	7.43	Yes	No	7	5	6
42	R:R:H310	R:R:K64	18.34	No	Yes	7	4	5
43	R:R:E313	R:R:K64	8.1	No	Yes	0	5	5
44	R:R:K317	R:R:K64	4.31	No	Yes	0	4	5
45	R:R:K65	R:R:R67	17.33	No	No	0	6	6
46	R:R:D71	R:R:L66	4.07	No	No	0	8	6
47	R:R:L66	R:R:L75	5.54	No	No	0	6	6
48	R:R:H310	R:R:R67	4.51	No	No	7	4	6
49	R:R:I69	R:R:Y73	7.25	Yes	Yes	5	6	7
50	R:R:D130	R:R:I69	4.2	No	Yes	5	8	6
51	R:R:I69	R:R:R145	3.76	Yes	Yes	5	6	7
52	R:R:K306	R:R:T70	4.5	No	No	0	6	8
53	R:R:D71	R:R:K306	5.53	No	No	0	8	6
54	R:R:L126	R:R:Y73	10.55	No	Yes	0	7	7
55	R:R:M127	R:R:Y73	5.99	No	Yes	0	9	7
56	R:R:D130	R:R:Y73	8.05	No	Yes	5	8	7
57	R:R:G150	R:R:Y73	4.35	No	Yes	0	7	7
58	R:R:L75	R:R:L79	5.54	No	No	0	6	6
59	R:R:F123	R:R:N76	13.29	Yes	No	3	8	9
60	R:R:C154	R:R:N76	11.02	No	No	3	7	9
61	R:R:N76	R:R:W158	4.52	No	Yes	3	9	9
62	R:R:D81	R:R:L77	5.43	No	No	0	9	9
63	R:R:S119	R:R:S80	6.52	No	No	3	7	8
64	R:R:S80	R:R:W158	3.71	No	Yes	3	8	9
65	R:R:F112	R:R:L83	8.53	No	No	0	5	6
66	R:R:F84	R:R:Y113	7.22	No	Yes	0	6	6
67	R:R:F84	R:R:G116	4.52	No	No	0	6	8
68	R:R:F88	R:R:V85	6.55	Yes	Yes	1	7	6
69	R:R:S87	R:R:Y113	5.09	No	Yes	0	7	6
70	R:R:F290	R:R:F88	11.79	Yes	Yes	1	7	7
71	R:R:F90	R:R:V109	6.55	No	No	0	6	5
72	R:R:Q91	R:R:Y94	4.51	Yes	No	0	6	5
73	R:R:L95	R:R:Q91	5.32	No	Yes	0	5	6
74	R:R:D97	R:R:Y93	8.05	No	No	0	4	2
75	R:R:V100	R:R:Y93	10.09	No	No	8	3	2
76	R:R:F101	R:R:Y93	10.32	No	No	8	7	2
77	R:R:W99	R:R:Y94	8.68	Yes	No	0	9	5
78	R:R:Q182	R:R:Y94	9.02	Yes	No	0	4	5
79	R:R:Q98	R:R:V100	4.3	No	No	0	4	3
80	R:R:L181	R:R:Q98	9.32	No	No	0	4	4
81	R:R:M105	R:R:W99	9.31	Yes	Yes	0	6	9
82	R:R:C106	R:R:W99	3.92	No	Yes	1	9	9
83	R:R:V174	R:R:W99	3.68	No	Yes	0	5	9
84	R:R:C183	R:R:W99	16.98	No	Yes	1	9	9
85	R:R:F101	R:R:V100	7.87	No	No	8	7	3
86	R:R:F101	R:R:M105	3.73	No	Yes	0	7	6
87	R:R:M105	R:R:V109	9.13	Yes	No	0	6	5
88	R:R:C106	R:R:C183	7.28	No	No	1	9	9
89	R:R:F112	R:R:V108	3.93	No	No	0	5	5
90	R:R:G111	R:R:S110	3.71	No	No	0	5	5
91	R:R:S110	R:R:Y172	10.17	No	No	0	5	4
92	R:R:Y113	R:R:Y114	3.97	Yes	Yes	1	6	5
93	R:R:L168	R:R:Y114	9.38	No	Yes	0	4	5
94	R:R:Y114	R:R:Y172	7.94	Yes	No	1	5	4
95	R:R:I115	R:R:T165	10.64	No	No	0	5	7
96	R:R:F117	R:R:M121	7.46	Yes	No	10	8	7
97	R:R:F117	R:R:M202	4.98	Yes	No	0	8	5
98	R:R:F117	R:R:W251	9.02	Yes	Yes	10	8	9
99	R:R:F122	R:R:Y118	4.13	No	Yes	0	5	7
100	R:R:A164	R:R:Y118	4	No	Yes	0	5	7
101	R:R:K201	R:R:Y118	7.17	No	Yes	0	4	7
102	R:R:M202	R:R:Y118	5.99	No	Yes	0	5	7
103	R:R:S119	R:R:W158	6.18	No	Yes	3	7	9
104	R:R:H292	R:R:S120	4.18	Yes	No	0	9	9
105	R:R:M121	R:R:W251	23.27	No	Yes	10	7	9
106	R:R:F122	R:R:V157	3.93	No	No	0	5	6
107	R:R:F122	R:R:T160	5.19	No	No	0	5	4
108	R:R:C154	R:R:F123	6.98	No	Yes	3	7	8
109	R:R:F123	R:R:V157	13.11	Yes	No	0	8	6
110	R:R:F123	R:R:W158	10.02	Yes	Yes	3	8	9
111	R:R:F214	R:R:I124	5.02	Yes	No	2	8	8
112	R:R:I124	R:R:N296	5.66	No	No	2	8	9
113	R:R:I124	R:R:Y300	7.25	No	Yes	2	8	9
114	R:R:P210	R:R:T125	6.99	No	No	0	9	7
115	R:R:L126	R:R:L153	5.54	No	No	0	7	6
116	R:R:M127	R:R:Y300	4.79	No	Yes	0	9	9
117	R:R:F214	R:R:S128	6.61	Yes	No	2	8	9
118	R:R:C217	R:R:S128	5.16	Yes	No	0	7	9
119	R:R:S128	R:R:Y218	6.36	No	Yes	2	9	9
120	R:R:D130	R:R:R145	14.29	No	Yes	5	8	7
121	R:R:R131	R:R:Y218	10.29	No	Yes	2	9	9
122	R:R:R131	R:R:V243	3.92	No	No	2	9	8
123	R:R:R131	R:R:Y300	7.2	No	Yes	2	9	9
124	R:R:V136	R:R:Y132	12.62	No	Yes	4	7	8
125	R:R:H137	R:R:Y132	7.62	No	Yes	4	6	8
126	R:R:F216	R:R:Y132	6.19	No	Yes	4	4	8
127	R:R:C217	R:R:Y132	9.41	Yes	Yes	0	7	8
128	R:R:K220	R:R:Y132	7.17	No	Yes	4	4	8
129	R:R:A134	R:R:R145	6.91	No	Yes	0	8	7
130	R:R:Q224	R:R:V135	4.3	No	No	0	5	8
131	R:R:H137	R:R:V136	12.45	No	No	4	6	7
132	R:R:Q224	R:R:V136	4.3	No	No	0	5	7
133	R:R:L168	R:R:T198	4.42	No	No	0	4	6
134	R:R:F171	R:R:W194	16.04	No	Yes	0	4	2
135	R:R:A175	R:R:Y184	4	No	Yes	0	1	2
136	R:R:L181	R:R:S176	6.01	No	No	0	4	3
137	R:R:E177	R:R:Q182	10.19	No	Yes	9	1	4
138	R:R:E177	R:R:Y184	7.86	No	Yes	9	1	2
139	R:R:Q182	R:R:V180	4.3	Yes	No	0	4	3
140	R:R:Q182	R:R:Y184	4.51	Yes	Yes	9	4	2
141	R:R:F186	R:R:Y184	12.38	No	Yes	0	4	2
142	R:R:S185	R:R:Y187	10.17	No	No	0	4	5
143	R:R:T191	R:R:Y187	7.49	No	No	0	3	5
144	R:R:K195	R:R:Y187	5.97	Yes	No	0	5	5
145	R:R:L192	R:R:Q189	3.99	No	No	0	1	4
146	R:R:T191	R:R:W194	3.64	No	Yes	0	3	2
147	R:R:F197	R:R:W194	6.01	No	Yes	0	4	2
148	R:R:K195	R:R:N199	4.2	Yes	No	0	5	5
149	R:R:F197	R:R:K201	6.2	No	No	0	4	4
150	R:R:N199	R:R:T198	5.85	No	No	0	5	6
151	R:R:F200	R:R:S262	6.61	No	No	0	5	5
152	R:R:N203	R:R:N255	5.45	No	No	0	6	8
153	R:R:F211	R:R:L207	6.09	Yes	No	0	7	8
154	R:R:L207	R:R:N255	17.85	No	No	0	8	8
155	R:R:I209	R:R:P210	5.08	No	No	0	6	9
156	R:R:F211	R:R:F214	5.36	Yes	Yes	0	7	8
157	R:R:F211	R:R:L248	3.65	Yes	No	0	7	6
158	R:R:F211	R:R:W251	5.01	Yes	Yes	0	7	9
159	R:R:F214	R:R:M215	3.73	Yes	Yes	0	8	4
160	R:R:F214	R:R:Y218	11.35	Yes	Yes	2	8	9
161	R:R:F214	R:R:S247	6.61	Yes	No	0	8	9
162	R:R:M215	R:R:V244	6.09	Yes	No	0	4	8
163	R:R:L248	R:R:M215	5.65	No	Yes	0	6	4
164	R:R:F216	R:R:K220	3.72	No	No	4	4	4
165	R:R:V240	R:R:Y218	8.83	No	Yes	0	7	9
166	R:R:V243	R:R:Y218	3.79	No	Yes	2	8	9
167	R:R:V244	R:R:Y218	3.79	No	Yes	0	8	9
168	R:R:I237	R:R:L222	4.28	Yes	No	0	7	5
169	R:R:L222	R:R:V240	5.96	No	No	0	5	7
170	R:R:I237	R:R:L225	5.71	Yes	No	0	7	8
171	R:R:K235	R:R:R238	4.95	No	No	0	7	6
172	R:R:L239	R:R:V303	5.96	No	No	0	8	7
173	R:R:F250	R:R:T291	7.78	Yes	No	0	8	5
174	R:R:F250	R:R:H292	4.53	Yes	Yes	0	8	9
175	R:R:F250	R:R:V295	7.87	Yes	No	0	8	6
176	R:R:H292	R:R:W251	13.75	Yes	Yes	0	9	9
177	R:R:F254	R:R:L258	6.09	Yes	No	0	7	5
178	R:R:F254	R:R:T285	3.89	Yes	No	0	7	6
179	R:R:E286	R:R:F254	7	No	Yes	0	5	7
180	R:R:F254	R:R:S289	6.61	Yes	No	0	7	8
181	R:R:T285	R:R:V257	9.52	No	No	0	6	5
182	R:R:F259	R:R:L263	14.61	No	No	0	6	4
183	R:R:L278	R:R:T261	4.42	No	No	0	5	4
184	R:R:D270	R:R:H264	5.04	No	No	0	1	2
185	R:R:H264	R:R:I274	3.98	No	Yes	0	2	3
186	R:R:H264	R:R:S275	5.58	No	No	0	2	1
187	R:R:D270	R:R:H267	15.13	No	No	0	1	1
188	R:R:Q277	R:R:S273	5.78	No	No	0	3	1
189	R:R:I274	R:R:Q277	8.23	Yes	No	0	3	3
190	R:R:Q276	R:R:Y280	4.51	No	No	0	3	3
191	R:R:T279	R:R:Y280	6.24	No	No	0	4	3
192	R:R:F290	R:R:I287	6.28	Yes	No	0	7	5
193	R:R:F290	R:R:S289	3.96	Yes	No	0	7	8
194	R:R:H292	R:R:N296	5.1	Yes	No	0	9	9
195	R:R:N296	R:R:Y300	8.14	No	Yes	2	9	9
196	R:R:F302	R:R:V298	7.87	Yes	No	0	6	6
197	R:R:A301	R:R:F307	6.93	No	Yes	0	7	8
198	R:R:F302	R:R:F307	5.36	Yes	Yes	6	6	8
199	R:R:E305	R:R:K309	5.4	No	No	0	4	5
200	R:R:F307	R:R:L311	3.65	Yes	No	0	8	6
201	R:R:G111	R:R:I115	3.53	No	No	0	5	5
202	R:R:Q224	R:R:R227	3.5	No	No	0	5	5
203	R:R:K193	R:R:W194	3.48	No	Yes	0	2	2
204	R:R:C272	R:R:S275	3.44	No	No	0	8	1
205	R:R:G111	R:R:L169	3.42	No	No	0	5	4
206	R:R:A78	R:R:V56	3.39	No	No	0	9	9
207	R:R:I166	R:R:P167	3.39	Yes	No	0	4	8
208	R:R:C43	R:R:T92	3.38	No	No	0	4	7
209	R:R:A78	R:R:I57	3.25	No	No	0	9	7
210	R:R:C63	R:R:K64	3.23	No	Yes	0	5	5
211	R:R:V61	R:R:V62	3.21	No	No	0	4	5
212	R:R:S68	R:R:T70	3.2	No	No	0	7	8
213	R:R:T103	R:R:V174	3.17	No	No	0	2	5
214	R:R:T282	R:R:V257	3.17	No	No	0	4	5
215	R:R:A301	R:R:L74	3.15	No	No	0	7	8
216	R:R:A236	R:R:L225	3.15	No	No	0	7	8
217	R:R:I69	R:R:S68	3.1	Yes	No	0	6	7
218	R:R:I196	R:R:S265	3.1	No	No	0	3	3
219	R:R:I57	R:R:V61	3.07	No	No	0	7	4
220	R:R:I221	R:R:V135	3.07	No	No	0	8	8
221	R:R:I299	R:R:V243	3.07	Yes	No	0	8	8
222	R:R:I299	R:R:V295	3.07	Yes	No	0	8	6
223	R:R:K195	R:R:S265	3.06	Yes	No	0	5	3
224	R:R:C272	R:R:Q276	3.05	No	No	0	8	3
225	R:R:M105	R:R:V108	3.04	Yes	No	0	6	5
226	R:R:I213	R:R:T125	3.04	No	No	0	7	7
227	R:R:K308	R:R:V303	3.04	No	No	0	8	7
228	R:R:F302	R:R:G52	3.01	Yes	No	0	6	8
229	R:R:M149	R:R:T146	3.01	No	No	0	3	7
230	R:R:K107	R:R:T103	3	No	No	0	7	2
231	R:R:K233	R:R:T234	3	No	No	0	6	4
232	R:R:L263	R:R:S262	3	No	No	0	4	5
233	R:R:L44	R:R:V40	2.98	No	No	0	5	5
234	R:R:L51	R:R:V47	2.98	No	No	0	4	6
235	R:R:L82	R:R:V85	2.98	No	Yes	0	7	6
236	R:R:N199	R:R:S262	2.98	No	No	0	5	5
237	R:R:L248	R:R:V252	2.98	No	No	0	6	5
238	R:R:L74	R:R:T70	2.95	No	No	0	8	8
239	R:R:L258	R:R:T261	2.95	No	No	0	5	4
240	R:R:I115	R:R:I162	2.94	No	No	0	5	3
241	R:R:I162	R:R:I166	2.94	No	Yes	0	3	4
242	R:R:I242	R:R:I299	2.94	No	Yes	0	5	8
243	R:R:I166	R:R:M163	2.92	Yes	No	0	4	4
244	R:R:I196	R:R:M266	2.92	No	No	0	3	3
245	R:R:I204	R:R:L208	2.85	No	No	0	5	4
246	R:R:I242	R:R:L239	2.85	No	No	0	5	8
247	R:R:I274	R:R:L278	2.85	Yes	No	0	3	5
248	R:R:K195	R:R:L192	2.82	Yes	No	0	5	1
249	R:R:K201	R:R:L205	2.82	No	No	0	4	5
250	R:R:A141	R:R:R145	2.77	No	Yes	0	6	7
251	R:R:L207	R:R:L208	2.77	No	No	0	8	4
252	R:R:L222	R:R:L241	2.77	No	No	0	5	5
253	R:R:L260	R:R:L278	2.77	No	No	0	4	5
254	R:R:E313	R:R:K309	2.7	No	No	0	5	5
255	R:R:H223	R:R:I219	2.65	No	No	0	3	4
256	R:R:F48	R:R:V47	2.62	No	No	0	5	6
257	R:R:R148	R:R:T146	2.59	No	No	0	4	7
258	R:R:H231	R:R:N230	2.55	No	No	0	3	4
259	R:R:V72	R:R:Y73	2.52	No	Yes	0	6	7
260	R:R:V144	R:R:Y140	2.52	No	No	0	4	4
261	R:R:T92	R:R:Y42	2.5	No	Yes	0	7	7
262	R:R:F86	R:R:L82	2.44	No	No	0	4	7
263	R:R:G179	R:R:S176	1.86	No	No	0	4	3
264	R:R:P253	R:R:V252	1.77	No	No	0	9	5
265	R:R:G271	R:R:I274	1.76	No	Yes	0	3	3
266	R:R:G52	R:R:L51	1.71	No	No	0	8	4
267	R:R:A161	R:R:S119	1.71	No	No	0	8	7
268	R:R:C217	R:R:V129	1.71	Yes	No	0	7	6
269	R:R:A281	R:R:V257	1.7	No	No	0	5	5
270	R:R:C217	R:R:I213	1.64	Yes	No	0	7	7
271	R:R:A246	R:R:I299	1.62	No	Yes	0	6	8
272	R:R:V252	R:R:V256	1.6	No	No	0	5	6
273	R:R:A141	R:R:L133	1.58	No	No	0	6	5
274	R:R:C228	R:R:N230	1.57	No	No	0	6	4
275	R:R:I166	R:R:V170	1.54	Yes	No	0	4	3
276	R:R:F117	R:R:G206	1.51	Yes	No	0	8	5
277	R:R:K35	R:R:T32	1.5	No	No	0	4	2
278	R:R:L155	R:R:T151	1.47	No	No	0	4	3
279	R:R:N188	R:R:T191	1.46	No	No	0	3	3
280	R:R:I219	R:R:M215	1.46	No	Yes	0	4	4
281	R:R:I268	R:R:M266	1.46	No	No	0	1	3
282	R:R:I237	R:R:K226	1.45	Yes	No	0	7	4
283	R:R:I237	R:R:K233	1.45	Yes	No	0	7	6
284	R:R:I268	R:R:L269	1.43	No	No	0	1	2
285	R:R:K235	R:R:L239	1.41	No	No	0	7	8
286	R:R:K107	R:R:Q173	1.36	No	No	0	7	4
287	R:R:H231	R:R:N232	1.28	No	No	0	3	5
288	R:R:F250	R:R:I288	1.26	Yes	No	0	8	7
289	R:R:H137	R:R:Y140	1.09	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.6667	9	1	0
2	R:R:Y42	6.32167	6	1	7
3	R:R:F46	5.88	4	1	7
4	R:R:S49	5.3425	4	0	8
5	R:R:K64	8.282	5	7	5
6	R:R:I69	4.5775	4	5	6
7	R:R:Y73	6.45167	6	5	7
8	R:R:V85	4.5775	4	1	6
9	R:R:F88	8.0075	4	1	7
10	R:R:Q91	11.115	4	1	6
11	R:R:W99	8.12167	6	1	9
12	R:R:M105	6.3025	4	0	6
13	R:R:Y113	8.6	4	1	6
14	R:R:Y114	7.36	4	1	5
15	R:R:F117	5.7425	4	10	8
16	R:R:Y118	5.3225	4	0	7
17	R:R:F123	10.85	4	3	8
18	R:R:Y132	8.602	5	4	8
19	R:R:R145	6.9325	4	5	7
20	R:R:W158	6.1075	4	3	9
21	R:R:I166	2.6975	4	0	4
22	R:R:Q182	7.005	4	9	4
23	R:R:Y184	7.1875	4	9	2
24	R:R:W194	7.2925	4	0	2
25	R:R:K195	4.0125	4	0	5
26	R:R:F211	5.0275	4	0	7
27	R:R:F214	6.44667	6	2	8
28	R:R:M215	4.2325	4	0	4
29	R:R:C217	4.48	4	0	7
30	R:R:Y218	7.40167	6	2	9
31	R:R:I237	3.2225	4	0	7
32	R:R:F250	5.36	4	0	8
33	R:R:W251	12.7625	4	10	9
34	R:R:F254	5.8975	4	0	7
35	R:R:I274	4.205	4	0	3
36	R:R:F290	8.0875	4	1	7
37	R:R:H292	6.89	4	0	9
38	R:R:I299	2.675	4	0	8
39	R:R:Y300	6.845	4	2	9
40	R:R:F302	5.496	5	6	6
41	R:R:F307	6.334	5	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q91	14.0842	26.74	Yes	Yes	1	0	6
2	L:L:?1	R:R:Y42	26.3225	6.34	Yes	Yes	1	0	7
3	R:R:F88	R:R:Y42	17.5832	6.19	Yes	Yes	1	7	7
4	L:L:?1	R:R:T198	94.0985	4.56	Yes	No	0	0	6
5	R:R:N199	R:R:T198	95.7626	5.85	No	No	0	5	6
6	R:R:K195	R:R:N199	97.1732	4.2	Yes	No	0	5	5
7	R:R:K195	R:R:Y187	98.9035	5.97	Yes	No	0	5	5
8	R:R:T191	R:R:Y187	99.2231	7.49	No	No	0	3	5
9	R:R:T191	R:R:W194	99.4986	3.64	No	Yes	0	3	2
10	R:R:F197	R:R:W194	99.752	6.01	No	Yes	0	4	2
11	R:R:F197	R:R:K201	99.8402	6.2	No	No	0	4	4
12	R:R:K201	R:R:Y118	99.9835	7.17	No	Yes	0	4	7
13	R:R:M202	R:R:Y118	100	5.99	No	Yes	0	5	7
14	R:R:F117	R:R:M202	99.9229	4.98	Yes	No	0	8	5
15	R:R:F117	R:R:W251	98.9365	9.02	Yes	Yes	10	8	9
16	R:R:H292	R:R:W251	58.8991	13.75	Yes	Yes	0	9	9
17	R:R:F250	R:R:H292	13.5001	4.53	Yes	Yes	0	8	9
18	R:R:F88	R:R:V85	13.9905	6.55	Yes	Yes	1	7	6
19	R:R:S49	R:R:V85	10.0231	4.85	Yes	Yes	0	8	6
20	R:R:H292	R:R:N296	48.7657	5.1	Yes	No	0	9	9
21	R:R:N296	R:R:Y300	46.49	8.14	No	Yes	2	9	9
22	R:R:M127	R:R:Y300	67.451	4.79	No	Yes	0	9	9
23	R:R:M127	R:R:Y73	66.5528	5.99	No	Yes	0	9	7
24	R:R:I69	R:R:Y73	54.7939	7.25	Yes	Yes	5	6	7
25	R:R:I69	R:R:S68	49.4875	3.1	Yes	No	0	6	7
26	R:R:S68	R:R:T70	48.3304	3.2	No	No	0	7	8
27	R:R:L74	R:R:T70	40.043	2.95	No	No	0	8	8
28	R:R:A301	R:R:L74	38.7701	3.15	No	No	0	7	8
29	R:R:A301	R:R:F307	37.5468	6.93	No	Yes	0	7	8
30	R:R:F302	R:R:F307	10.1774	5.36	Yes	Yes	6	6	8
31	R:R:F307	R:R:V59	16.2056	10.49	Yes	No	0	8	7
32	R:R:I314	R:R:V59	14.8997	4.61	No	No	0	4	7
33	R:R:C63	R:R:I314	13.5607	6.55	No	No	0	5	4
34	R:R:C63	R:R:K64	12.1005	3.23	No	Yes	0	5	5
35	R:R:F122	R:R:Y118	14.3762	4.13	No	Yes	0	5	7
36	R:R:F122	R:R:V157	11.5881	3.93	No	No	0	5	6
37	R:R:F123	R:R:V157	10.1774	13.11	Yes	No	0	8	6
38	L:L:?1	R:R:W99	33.6842	6.16	Yes	Yes	1	0	9
39	R:R:M105	R:R:W99	19.5889	9.31	Yes	Yes	0	6	9
40	R:R:F101	R:R:M105	11.4558	3.73	No	Yes	0	7	6
41	R:R:Q182	R:R:Y94	15.335	9.02	Yes	No	0	4	5
42	L:L:?1	R:R:Y172	15.3571	9.96	Yes	No	1	0	4
43	R:R:S110	R:R:Y172	14.3873	10.17	No	No	0	5	4
44	R:R:G111	R:R:S110	13.1364	3.71	No	No	0	5	5
45	R:R:G111	R:R:I115	10.2931	3.53	No	No	0	5	5
46	R:R:F211	R:R:W251	43.4869	5.01	Yes	Yes	0	7	9
47	R:R:F211	R:R:F214	37.0509	5.36	Yes	Yes	0	7	8
48	R:R:F214	R:R:I124	13.2962	5.02	Yes	No	2	8	8
49	R:R:F214	R:R:S128	23.2037	6.61	Yes	No	2	8	9
50	R:R:C217	R:R:S128	29.5019	5.16	Yes	No	0	7	9
51	R:R:F214	R:R:Y218	13.0317	11.35	Yes	Yes	2	8	9
52	R:R:C217	R:R:Y132	19.4512	9.41	Yes	Yes	0	7	8
53	R:R:V240	R:R:Y218	13.434	8.83	No	Yes	0	7	9
54	R:R:L222	R:R:V240	11.9848	5.96	No	No	0	5	7
55	L:L:?1	R:R:E286	28.8902	12.29	Yes	No	0	0	5
56	R:R:E286	R:R:F254	27.7496	7	No	Yes	0	5	7
57	R:R:F254	R:R:L258	22.6692	6.09	Yes	No	0	7	5
58	R:R:L258	R:R:T261	21.3247	2.95	No	No	0	5	4
59	R:R:L278	R:R:T261	19.9581	4.42	No	No	0	5	4
60	R:R:I274	R:R:L278	17.3738	2.85	Yes	No	0	3	5
61	R:R:H264	R:R:I274	11.7479	3.98	No	Yes	0	2	3
62	R:R:R131	R:R:Y300	12.7287	7.2	No	Yes	2	9	9
63	R:R:I124	R:R:Y300	11.3346	7.25	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y42	6.34	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q91	26.74	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W99	6.16	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y113	18.12	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y114	8.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y172	9.96	1	Yes	No	0	4	0	1
L:L:?1	R:R:C183	3.68	1	Yes	No	0	9	0	1
L:L:?1	R:R:T198	4.56	1	Yes	No	0	6	0	1
L:L:?1	R:R:E286	12.29	1	Yes	No	0	5	0	1
R:R:L38	R:R:Y42	4.69	0	No	Yes	6	7	2	1
R:R:L38	R:R:L95	4.15	0	No	No	6	5	2	2
R:R:F88	R:R:Y42	6.19	1	Yes	Yes	7	7	2	1
R:R:Q91	R:R:Y42	7.89	1	Yes	Yes	6	7	1	1
R:R:F290	R:R:Y42	10.32	1	Yes	Yes	7	7	2	1
R:R:F84	R:R:Y113	7.22	0	No	Yes	6	6	2	1
R:R:S87	R:R:Y113	5.09	0	No	Yes	7	6	2	1
R:R:F290	R:R:F88	11.79	1	Yes	Yes	7	7	2	2
R:R:Q91	R:R:Y94	4.51	1	Yes	No	6	5	1	2
R:R:L95	R:R:Q91	5.32	0	No	Yes	5	6	2	1
R:R:W99	R:R:Y94	8.68	1	Yes	No	9	5	1	2
R:R:M105	R:R:W99	9.31	0	Yes	Yes	6	9	2	1
R:R:C106	R:R:W99	3.92	1	No	Yes	9	9	2	1
R:R:V174	R:R:W99	3.68	0	No	Yes	5	9	2	1
R:R:C183	R:R:W99	16.98	1	No	Yes	9	9	1	1
R:R:C106	R:R:C183	7.28	1	No	No	9	9	2	1
R:R:S110	R:R:Y172	10.17	0	No	No	5	4	2	1
R:R:Y113	R:R:Y114	3.97	1	Yes	Yes	6	5	1	1
R:R:L168	R:R:Y114	9.38	0	No	Yes	4	5	2	1
R:R:Y114	R:R:Y172	7.94	1	Yes	No	5	4	1	1
R:R:L168	R:R:T198	4.42	0	No	No	4	6	2	1
R:R:N199	R:R:T198	5.85	0	No	No	5	6	2	1
R:R:E286	R:R:F254	7	0	No	Yes	5	7	1	2
R:R:T92	R:R:Y42	2.5	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8KFY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	263
Number of Links	289
Number of Hubs	41
Number of Links mediated by Hubs	155
Number of Communities	10
Number of Nodes involved in Communities	51
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	36587
Length Of Smallest Path	3
Average Path Length	16.5418
Length of Longest Path	43
Minimum Path Strength	1.445
Average Path Strength	6.05292
Maximum Path Strength	22.43
Minimum Path Correlation	0.7
Average Path Correlation	0.923078
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	40.1461
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1709
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	OXF
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OXF
Name	2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol
Synonyms	ZK-756326
Identifier
Formula	C21 H28 N2 O3
Molecular Weight	356.459
SMILES
PubChem	11688990
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51685
Sequence	>8KFY_nogp_Chain_R I Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C K K L R S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D Q W V F G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H A V Y A L K V R T I R M G T T L C L A V W L T A I M A T I P L L V F Y Q V A S E D G V L Q C Y S F Y N Q Q T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C Q N H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I L D G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K F K K H L S E I F Q K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TLM	A	Protein	Chemokine	CCR8	Homo sapiens	Anti-murine CCR8 antibody	-	-	3.9	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-	Gi1/β1/γ2	3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-		3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8KFX	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-	Gi1/β1/γ2	2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFX (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-		2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-	Gi1/β1/γ2	3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-		3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8XML	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	2.58	2025-01-01	To be published
	8XML (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		2.58	2025-01-01	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KFY_nogp.zip

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