Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.6667910
2R:R:Y42 6.32167617
3R:R:F46 5.88417
4R:R:S49 5.3425408
5R:R:K64 8.282575
6R:R:I69 4.5775456
7R:R:Y73 6.45167657
8R:R:V85 4.5775416
9R:R:F88 8.0075417
10R:R:Q91 11.115416
11R:R:W99 8.12167619
12R:R:M105 6.3025406
13R:R:Y113 8.6416
14R:R:Y114 7.36415
15R:R:F117 5.74254108
16R:R:Y118 5.3225407
17R:R:F123 10.85438
18R:R:Y132 8.602548
19R:R:R145 6.9325457
20R:R:W158 6.1075439
21R:R:I166 2.6975404
22R:R:Q182 7.005494
23R:R:Y184 7.1875492
24R:R:W194 7.2925402
25R:R:K195 4.0125405
26R:R:F211 5.0275407
27R:R:F214 6.44667628
28R:R:M215 4.2325404
29R:R:C217 4.48407
30R:R:Y218 7.40167629
31R:R:I237 3.2225407
32R:R:F250 5.36408
33R:R:W251 12.76254109
34R:R:F254 5.8975407
35R:R:I274 4.205403
36R:R:F290 8.0875417
37R:R:H292 6.89409
38R:R:I299 2.675408
39R:R:Y300 6.845429
40R:R:F302 5.496566
41R:R:F307 6.334568
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Q91 14.084226.74YesYes106
2L:L:?1 R:R:Y42 26.32256.34YesYes107
3R:R:F88 R:R:Y42 17.58326.19YesYes177
4L:L:?1 R:R:T198 94.09854.56YesNo006
5R:R:N199 R:R:T198 95.76265.85NoNo056
6R:R:K195 R:R:N199 97.17324.2YesNo055
7R:R:K195 R:R:Y187 98.90355.97YesNo055
8R:R:T191 R:R:Y187 99.22317.49NoNo035
9R:R:T191 R:R:W194 99.49863.64NoYes032
10R:R:F197 R:R:W194 99.7526.01NoYes042
11R:R:F197 R:R:K201 99.84026.2NoNo044
12R:R:K201 R:R:Y118 99.98357.17NoYes047
13R:R:M202 R:R:Y118 1005.99NoYes057
14R:R:F117 R:R:M202 99.92294.98YesNo085
15R:R:F117 R:R:W251 98.93659.02YesYes1089
16R:R:H292 R:R:W251 58.899113.75YesYes099
17R:R:F250 R:R:H292 13.50014.53YesYes089
18R:R:F88 R:R:V85 13.99056.55YesYes176
19R:R:S49 R:R:V85 10.02314.85YesYes086
20R:R:H292 R:R:N296 48.76575.1YesNo099
21R:R:N296 R:R:Y300 46.498.14NoYes299
22R:R:M127 R:R:Y300 67.4514.79NoYes099
23R:R:M127 R:R:Y73 66.55285.99NoYes097
24R:R:I69 R:R:Y73 54.79397.25YesYes567
25R:R:I69 R:R:S68 49.48753.1YesNo067
26R:R:S68 R:R:T70 48.33043.2NoNo078
27R:R:L74 R:R:T70 40.0432.95NoNo088
28R:R:A301 R:R:L74 38.77013.15NoNo078
29R:R:A301 R:R:F307 37.54686.93NoYes078
30R:R:F302 R:R:F307 10.17745.36YesYes668
31R:R:F307 R:R:V59 16.205610.49YesNo087
32R:R:I314 R:R:V59 14.89974.61NoNo047
33R:R:C63 R:R:I314 13.56076.55NoNo054
34R:R:C63 R:R:K64 12.10053.23NoYes055
35R:R:F122 R:R:Y118 14.37624.13NoYes057
36R:R:F122 R:R:V157 11.58813.93NoNo056
37R:R:F123 R:R:V157 10.177413.11YesNo086
38L:L:?1 R:R:W99 33.68426.16YesYes109
39R:R:M105 R:R:W99 19.58899.31YesYes069
40R:R:F101 R:R:M105 11.45583.73NoYes076
41R:R:Q182 R:R:Y94 15.3359.02YesNo045
42L:L:?1 R:R:Y172 15.35719.96YesNo104
43R:R:S110 R:R:Y172 14.387310.17NoNo054
44R:R:G111 R:R:S110 13.13643.71NoNo055
45R:R:G111 R:R:I115 10.29313.53NoNo055
46R:R:F211 R:R:W251 43.48695.01YesYes079
47R:R:F211 R:R:F214 37.05095.36YesYes078
48R:R:F214 R:R:I124 13.29625.02YesNo288
49R:R:F214 R:R:S128 23.20376.61YesNo289
50R:R:C217 R:R:S128 29.50195.16YesNo079
51R:R:F214 R:R:Y218 13.031711.35YesYes289
52R:R:C217 R:R:Y132 19.45129.41YesYes078
53R:R:V240 R:R:Y218 13.4348.83NoYes079
54R:R:L222 R:R:V240 11.98485.96NoNo057
55L:L:?1 R:R:E286 28.890212.29YesNo005
56R:R:E286 R:R:F254 27.74967NoYes057
57R:R:F254 R:R:L258 22.66926.09YesNo075
58R:R:L258 R:R:T261 21.32472.95NoNo054
59R:R:L278 R:R:T261 19.95814.42NoNo054
60R:R:I274 R:R:L278 17.37382.85YesNo035
61R:R:H264 R:R:I274 11.74793.98NoYes023
62R:R:R131 R:R:Y300 12.72877.2NoYes299
63R:R:I124 R:R:Y300 11.33467.25NoYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y42 6.34 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Q91 26.74 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W99 6.16 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y113 18.12 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y114 8.15 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y172 9.96 1 Yes No 0 4 0 1
L:L:?1 R:R:C183 3.68 1 Yes No 0 9 0 1
L:L:?1 R:R:T198 4.56 1 Yes No 0 6 0 1
L:L:?1 R:R:E286 12.29 1 Yes No 0 5 0 1
R:R:L38 R:R:Y42 4.69 0 No Yes 6 7 2 1
R:R:L38 R:R:L95 4.15 0 No No 6 5 2 2
R:R:F88 R:R:Y42 6.19 1 Yes Yes 7 7 2 1
R:R:Q91 R:R:Y42 7.89 1 Yes Yes 6 7 1 1
R:R:F290 R:R:Y42 10.32 1 Yes Yes 7 7 2 1
R:R:F84 R:R:Y113 7.22 0 No Yes 6 6 2 1
R:R:S87 R:R:Y113 5.09 0 No Yes 7 6 2 1
R:R:F290 R:R:F88 11.79 1 Yes Yes 7 7 2 2
R:R:Q91 R:R:Y94 4.51 1 Yes No 6 5 1 2
R:R:L95 R:R:Q91 5.32 0 No Yes 5 6 2 1
R:R:W99 R:R:Y94 8.68 1 Yes No 9 5 1 2
R:R:M105 R:R:W99 9.31 0 Yes Yes 6 9 2 1
R:R:C106 R:R:W99 3.92 1 No Yes 9 9 2 1
R:R:V174 R:R:W99 3.68 0 No Yes 5 9 2 1
R:R:C183 R:R:W99 16.98 1 No Yes 9 9 1 1
R:R:C106 R:R:C183 7.28 1 No No 9 9 2 1
R:R:S110 R:R:Y172 10.17 0 No No 5 4 2 1
R:R:Y113 R:R:Y114 3.97 1 Yes Yes 6 5 1 1
R:R:L168 R:R:Y114 9.38 0 No Yes 4 5 2 1
R:R:Y114 R:R:Y172 7.94 1 Yes No 5 4 1 1
R:R:L168 R:R:T198 4.42 0 No No 4 6 2 1
R:R:N199 R:R:T198 5.85 0 No No 5 6 2 1
R:R:E286 R:R:F254 7 0 No Yes 5 7 1 2
R:R:T92 R:R:Y42 2.5 0 No Yes 7 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8KFY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.64
Number of Linked Nodes 263
Number of Links 289
Number of Hubs 41
Number of Links mediated by Hubs 155
Number of Communities 10
Number of Nodes involved in Communities 51
Number of Links involved in Communities 64
Path Summary
Number Of Nodes in MetaPath 64
Number Of Links MetaPath 63
Number of Shortest Paths 36587
Length Of Smallest Path 3
Average Path Length 16.5418
Length of Longest Path 43
Minimum Path Strength 1.445
Average Path Strength 6.05292
Maximum Path Strength 22.43
Minimum Path Correlation 0.7
Average Path Correlation 0.923078
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 40.1461
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.1709
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • coreceptor activity   • signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • chemokine binding   • cytokine binding   • chemotaxis   • taxis   • response to external stimulus   • locomotion   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell chemotaxis   • cell migration   • cell motility   • immune response   • immune system process   • cell adhesion   • calcium-mediated signaling   • cell surface   • external side of plasma membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeOXF
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOXF
Name2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol
SynonymsZK-756326
Identifier
FormulaC21 H28 N2 O3
Molecular Weight356.459
SMILES
PubChem11688990
Formal Charge0
Total Atoms54
Total Chiral Atoms0
Total Bonds56
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP51685
Sequence
>8KFY_nogp_Chain_R
IQTNGKLLL AVFYCLLFV FSLLGNSLV ILVLVVCKK LRSITDVYL 
LNLALSDLL FVFSFPFQT YYLLDQWVF GTVMCKVVS GFYYIGFYS 
SMFFITLMS VDRYLAVVH AVYALKVRT IRMGTTLCL AVWLTAIMA 
TIPLLVFYQ VASEDGVLQ CYSFYNQQT LKWKIFTNF KMNILGLLI 
PFTIFMFCY IKILHQLKR CQNHNKTKA IRLVLIVVI ASLLFWVPF 
NVVLFLTSL HSMHILDGC SISQQLTYA THVTEIISF THCCVNPVI 
YAFVGEKFK KHLSEIFQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TLMAProteinChemokineCCR8Homo sapiensAnti-murine CCR8 antibody--3.92023-12-20doi.org/10.1038/s41467-023-43601-8
8U1UAProteinChemokineCCR8Homo sapiensCCL1-Gi1/β1/γ23.12023-12-20doi.org/10.1038/s41467-023-43601-8
8U1U (No Gprot) AProteinChemokineCCR8Homo sapiensCCL1-3.12023-12-20doi.org/10.1038/s41467-023-43601-8
8KFXAProteinChemokineCCR8Homo sapiensLMD-009-Gi1/β1/γ22.962024-02-07doi.org/10.1126/sciadv.adj7500
8KFX (No Gprot) AProteinChemokineCCR8Homo sapiensLMD-009-2.962024-02-07doi.org/10.1126/sciadv.adj7500
8KFYAProteinChemokineCCR8Homo sapiensZK-756326-Gi1/β1/γ23.062024-02-07doi.org/10.1126/sciadv.adj7500
8KFY (No Gprot) AProteinChemokineCCR8Homo sapiensZK-756326-3.062024-02-07doi.org/10.1126/sciadv.adj7500
8KFZAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ23.32024-02-07doi.org/10.1126/sciadv.adj7500
8KFZ (No Gprot) AProteinChemokineCCR8Homo sapiens--3.32024-02-07doi.org/10.1126/sciadv.adj7500
8XMLAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ22.582025-01-01To be published
8XML (No Gprot) AProteinChemokineCCR8Homo sapiens--2.582025-01-01To be published




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Download 8KFY_nogp.zip



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