psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F41	R:R:I287	7.54	No	No	0	4	5
2	R:R:C43	R:R:F88	4.19	No	Yes	1	4	7
3	R:R:C43	R:R:T92	3.38	No	No	1	4	7
4	R:R:L44	R:R:V47	4.47	No	No	0	5	6
5	R:R:L45	R:R:T291	7.37	No	No	0	7	5
6	R:R:C294	R:R:L45	4.76	No	No	0	7	7
7	R:R:F46	R:R:V85	5.24	Yes	No	0	7	6
8	R:R:F46	R:R:P89	7.22	Yes	No	0	7	8
9	R:R:C294	R:R:F48	6.98	No	No	0	7	5
10	R:R:N53	R:R:S49	4.47	Yes	No	0	9	8
11	R:R:S49	R:R:V85	8.08	No	No	0	8	6
12	R:R:C294	R:R:S49	6.89	No	No	0	7	8
13	R:R:D81	R:R:N53	8.08	Yes	Yes	0	9	9
14	R:R:L82	R:R:N53	4.12	No	Yes	0	7	9
15	R:R:N53	R:R:P297	9.77	Yes	No	0	9	9
16	R:R:L60	R:R:V56	2.98	No	No	4	7	9
17	R:R:L74	R:R:V56	4.47	No	No	4	8	9
18	R:R:A78	R:R:V56	3.39	No	No	0	9	9
19	R:R:I57	R:R:V61	3.07	Yes	No	5	7	4
20	R:R:I57	R:R:L75	5.71	Yes	No	5	7	6
21	R:R:A78	R:R:I57	3.25	No	Yes	0	9	7
22	R:R:L58	R:R:V62	7.45	No	No	0	3	5
23	R:R:F307	R:R:V59	9.18	Yes	No	0	8	7
24	R:R:D71	R:R:L60	4.07	No	No	0	8	7
25	R:R:L60	R:R:L74	4.15	No	No	4	7	8
26	R:R:L75	R:R:V61	4.47	No	No	5	6	4
27	R:R:C63	R:R:K65	6.47	No	No	0	5	6
28	R:R:H310	R:R:K65	14.41	No	No	0	4	6
29	R:R:L66	R:R:V72	2.98	No	No	0	6	6
30	R:R:L66	R:R:L75	4.15	No	No	0	6	6
31	R:R:I69	R:R:S68	3.1	Yes	No	0	6	7
32	R:R:S68	R:R:T70	3.2	No	No	0	7	8
33	R:R:I69	R:R:Y73	9.67	Yes	Yes	2	6	7
34	R:R:D130	R:R:I69	7	No	Yes	2	8	6
35	R:R:I69	R:R:R145	5.01	Yes	Yes	2	6	7
36	R:R:G150	R:R:I69	3.53	No	Yes	2	7	6
37	R:R:D71	R:R:K306	6.91	No	No	0	8	6
38	R:R:L126	R:R:Y73	7.03	No	Yes	2	7	7
39	R:R:M127	R:R:Y73	4.79	No	Yes	0	9	7
40	R:R:D130	R:R:Y73	6.9	No	Yes	2	8	7
41	R:R:G150	R:R:Y73	4.35	No	Yes	2	7	7
42	R:R:L153	R:R:Y73	3.52	No	Yes	2	6	7
43	R:R:A301	R:R:L74	3.15	No	No	0	7	8
44	R:R:F123	R:R:N76	8.46	Yes	No	3	8	9
45	R:R:C154	R:R:N76	9.45	No	No	3	7	9
46	R:R:N76	R:R:W158	3.39	No	Yes	3	9	9
47	R:R:D81	R:R:L77	4.07	Yes	No	0	9	9
48	R:R:L77	R:R:Y300	3.52	No	Yes	0	9	9
49	R:R:S119	R:R:S80	4.89	No	No	3	7	8
50	R:R:F123	R:R:S80	3.96	Yes	No	3	8	8
51	R:R:S80	R:R:W158	6.18	No	Yes	3	8	9
52	R:R:C293	R:R:D81	7.78	Yes	Yes	1	8	9
53	R:R:D81	R:R:N296	8.08	Yes	Yes	1	9	9
54	R:R:F112	R:R:L83	13.4	No	No	0	5	6
55	R:R:F84	R:R:Y113	9.28	Yes	Yes	1	6	6
56	R:R:F84	R:R:G116	3.01	Yes	No	0	6	8
57	R:R:F290	R:R:F84	6.43	Yes	Yes	1	7	6
58	R:R:C293	R:R:F84	6.98	Yes	Yes	1	8	6
59	R:R:S87	R:R:Y113	5.09	No	Yes	0	7	6
60	R:R:F88	R:R:P89	5.78	Yes	No	0	7	8
61	R:R:F88	R:R:T92	5.19	Yes	No	1	7	7
62	R:R:F290	R:R:F88	16.08	Yes	Yes	1	7	7
63	R:R:F90	R:R:W99	11.02	No	No	0	6	9
64	R:R:F90	R:R:V109	5.24	No	No	0	6	5
65	R:R:Q91	R:R:Y113	9.02	No	Yes	0	6	6
66	R:R:D97	R:R:Y94	14.94	No	No	0	4	5
67	R:R:D97	R:R:F101	8.36	No	No	0	4	7
68	R:R:Q98	R:R:W99	15.33	No	No	0	4	9
69	R:R:T103	R:R:V100	3.17	No	No	0	2	3
70	R:R:C106	R:R:C183	5.46	No	No	0	9	9
71	R:R:F112	R:R:V108	5.24	No	No	0	5	5
72	R:R:S110	R:R:Y114	3.82	No	No	0	5	5
73	R:R:Y113	R:R:Y114	11.91	Yes	No	0	6	5
74	R:R:E286	R:R:Y113	5.61	No	Yes	1	5	6
75	R:R:F290	R:R:Y113	3.09	Yes	Yes	1	7	6
76	R:R:M202	R:R:Y114	4.79	No	No	0	5	5
77	R:R:I115	R:R:T165	6.08	No	No	0	5	7
78	R:R:F117	R:R:Y118	11.35	No	Yes	0	8	7
79	R:R:F117	R:R:M121	3.73	No	Yes	1	8	7
80	R:R:F117	R:R:W251	5.01	No	Yes	1	8	9
81	R:R:W122	R:R:Y118	3.86	No	Yes	0	5	7
82	R:R:M202	R:R:Y118	7.18	No	Yes	0	5	7
83	R:R:S119	R:R:W158	8.65	No	Yes	3	7	9
84	R:R:C293	R:R:S120	3.44	Yes	No	0	8	9
85	R:R:M121	R:R:P210	3.35	Yes	Yes	0	7	9
86	R:R:F211	R:R:M121	6.22	Yes	Yes	1	7	7
87	R:R:M121	R:R:W251	10.47	Yes	Yes	1	7	9
88	R:R:T125	R:R:W122	4.85	No	No	0	7	5
89	R:R:P210	R:R:W122	8.11	Yes	No	0	9	5
90	R:R:C154	R:R:F123	6.98	No	Yes	3	7	8
91	R:R:F123	R:R:V157	10.49	Yes	No	0	8	6
92	R:R:F123	R:R:W158	10.02	Yes	Yes	3	8	9
93	R:R:F214	R:R:I124	5.02	Yes	No	0	8	8
94	R:R:I124	R:R:Y300	6.04	No	Yes	0	8	9
95	R:R:L126	R:R:L153	4.15	No	No	2	7	6
96	R:R:L126	R:R:V157	2.98	No	No	0	7	6
97	R:R:M127	R:R:Y300	8.38	No	Yes	0	9	9
98	R:R:F214	R:R:S128	3.96	Yes	No	1	8	9
99	R:R:C217	R:R:S128	5.16	Yes	No	0	7	9
100	R:R:S128	R:R:Y218	5.09	No	Yes	1	9	9
101	R:R:D130	R:R:R145	15.48	No	Yes	2	8	7
102	R:R:R131	R:R:Y218	8.23	No	Yes	0	9	9
103	R:R:R131	R:R:Y300	7.2	No	Yes	0	9	9
104	R:R:L133	R:R:Y132	3.52	No	Yes	0	5	8
105	R:R:V136	R:R:Y132	10.09	No	Yes	6	7	8
106	R:R:H137	R:R:Y132	4.36	No	Yes	6	6	8
107	R:R:C217	R:R:Y132	9.41	Yes	Yes	0	7	8
108	R:R:K220	R:R:Y132	3.58	No	Yes	0	4	8
109	R:R:A134	R:R:R145	6.91	No	Yes	0	8	7
110	R:R:L225	R:R:V135	2.98	No	No	0	8	8
111	R:R:H137	R:R:V136	5.54	No	No	6	6	7
112	R:R:Q224	R:R:V136	5.73	No	No	0	5	7
113	R:R:K143	R:R:Y140	4.78	No	No	0	5	4
114	R:R:V144	R:R:Y140	8.83	No	No	0	4	4
115	R:R:L153	R:R:M149	5.65	No	No	0	6	3
116	R:R:I166	R:R:P167	3.39	No	No	0	4	8
117	R:R:N199	R:R:T198	5.85	No	No	0	5	6
118	R:R:N199	R:R:S262	7.45	No	No	0	5	5
119	R:R:F200	R:R:F259	3.22	No	No	0	5	6
120	R:R:F200	R:R:S262	6.61	No	No	0	5	5
121	R:R:L207	R:R:N203	4.12	Yes	No	1	8	6
122	R:R:N203	R:R:N255	4.09	No	No	1	6	8
123	R:R:F259	R:R:N203	4.83	No	No	0	6	6
124	R:R:G206	R:R:P210	4.06	No	Yes	0	5	9
125	R:R:L207	R:R:L208	4.15	Yes	No	0	8	4
126	R:R:L207	R:R:N255	16.48	Yes	No	1	8	8
127	R:R:I209	R:R:P210	3.39	No	Yes	0	6	9
128	R:R:F211	R:R:F214	5.36	Yes	Yes	1	7	8
129	R:R:F211	R:R:S247	5.28	Yes	No	1	7	9
130	R:R:F211	R:R:W251	6.01	Yes	Yes	1	7	9
131	R:R:F214	R:R:Y218	12.38	Yes	Yes	1	8	9
132	R:R:F214	R:R:S247	7.93	Yes	No	1	8	9
133	R:R:M215	R:R:V244	3.04	No	No	1	4	8
134	R:R:L248	R:R:M215	5.65	No	No	1	6	4
135	R:R:F216	R:R:K220	7.44	No	No	0	4	4
136	R:R:V240	R:R:Y218	8.83	No	Yes	0	7	9
137	R:R:V243	R:R:Y218	5.05	No	Yes	0	8	9
138	R:R:V244	R:R:Y218	5.05	No	Yes	1	8	9
139	R:R:H223	R:R:I219	3.98	No	No	0	3	4
140	R:R:I221	R:R:V240	3.07	No	No	0	8	7
141	R:R:I237	R:R:L222	4.28	No	No	0	7	5
142	R:R:L222	R:R:V240	5.96	No	No	0	5	7
143	R:R:Q224	R:R:R227	5.84	No	No	0	5	5
144	R:R:A236	R:R:L225	3.15	No	No	0	7	8
145	R:R:C228	R:R:K233	3.23	No	No	0	6	6
146	R:R:N232	R:R:Q229	6.6	No	No	0	5	5
147	R:R:K233	R:R:N230	5.6	No	No	0	6	4
148	R:R:R238	R:R:T234	3.88	No	No	0	6	4
149	R:R:K235	R:R:R238	3.71	No	No	0	7	6
150	R:R:K235	R:R:L239	4.23	No	No	0	7	8
151	R:R:E305	R:R:K235	8.1	No	No	0	4	7
152	R:R:L239	R:R:V303	4.47	No	No	0	8	7
153	R:R:L248	R:R:V244	2.98	No	No	1	6	8
154	R:R:L248	R:R:V252	2.98	No	No	0	6	5
155	R:R:F250	R:R:I288	5.02	Yes	No	0	8	7
156	R:R:F250	R:R:H292	13.58	Yes	No	0	8	9
157	R:R:F250	R:R:V295	7.87	Yes	No	0	8	6
158	R:R:F254	R:R:W251	3.01	Yes	Yes	1	7	9
159	R:R:S289	R:R:W251	3.71	No	Yes	1	8	9
160	R:R:H292	R:R:W251	22.22	No	Yes	0	9	9
161	R:R:P253	R:R:V252	3.53	No	No	0	9	5
162	R:R:P253	R:R:T285	3.5	No	No	0	9	6
163	R:R:F254	R:R:L258	3.65	Yes	No	0	7	5
164	R:R:F254	R:R:T285	3.89	Yes	No	0	7	6
165	R:R:E286	R:R:F254	7	No	Yes	1	5	7
166	R:R:F254	R:R:S289	17.18	Yes	No	1	7	8
167	R:R:T285	R:R:V257	7.93	No	No	0	6	5
168	R:R:L258	R:R:T261	2.95	No	No	0	5	4
169	R:R:E286	R:R:F290	10.49	No	Yes	1	5	7
170	R:R:H292	R:R:N296	19.13	No	Yes	0	9	9
171	R:R:C293	R:R:N296	3.15	Yes	Yes	1	8	9
172	R:R:I299	R:R:V295	3.07	No	No	0	8	6
173	R:R:N296	R:R:Y300	5.81	Yes	Yes	0	9	9
174	R:R:A301	R:R:F307	8.32	No	Yes	0	7	8
175	R:R:F302	R:R:F307	11.79	No	Yes	0	6	8
176	R:R:H310	R:R:K306	5.24	No	No	0	4	6
177	R:R:F307	R:R:L311	4.87	Yes	No	0	8	6
178	R:R:D71	R:R:S68	2.94	No	No	0	8	7
179	R:R:I204	R:R:I209	2.94	No	No	0	5	6
180	R:R:I242	R:R:I299	2.94	No	No	0	5	8
181	R:R:Q224	R:R:V135	2.87	No	No	0	5	8
182	R:R:I57	R:R:L79	2.85	Yes	No	0	7	6
183	R:R:I115	R:R:L83	2.85	No	No	0	5	6
184	R:R:I237	R:R:L241	2.85	No	No	0	7	5
185	R:R:I245	R:R:L249	2.85	No	No	0	5	6
186	R:R:L51	R:R:L55	2.77	No	No	0	4	6
187	R:R:A141	R:R:R145	2.77	No	Yes	0	6	7
188	R:R:A246	R:R:F250	2.77	No	Yes	0	6	8
189	R:R:F112	R:R:S87	2.64	No	No	0	5	7
190	R:R:F46	R:R:L50	2.44	Yes	No	0	7	6
191	R:R:F86	R:R:L50	2.44	No	No	0	4	6
192	R:R:F302	R:R:L55	2.44	No	No	0	6	6
193	R:R:F211	R:R:L207	2.44	Yes	Yes	1	7	8
194	R:R:L205	R:R:Y118	2.34	No	Yes	0	5	7
195	R:R:G52	R:R:P297	2.03	No	No	0	8	9
196	R:R:G102	R:R:T103	1.82	No	No	0	8	2
197	R:R:A161	R:R:S119	1.71	No	No	0	8	7
198	R:R:C217	R:R:V129	1.71	Yes	No	0	7	6
199	R:R:K201	R:R:P167	1.67	No	No	0	4	8
200	R:R:C217	R:R:I213	1.64	Yes	No	0	7	7
201	R:R:S87	R:R:V109	1.62	No	No	0	7	5
202	R:R:V104	R:R:V108	1.6	No	No	0	4	5
203	R:R:V252	R:R:V256	1.6	No	No	0	5	6
204	R:R:T151	R:R:V72	1.59	No	No	0	3	6
205	R:R:C228	R:R:L225	1.59	No	No	0	6	8
206	R:R:T151	R:R:T152	1.57	No	No	0	3	3
207	R:R:I147	R:R:V72	1.54	No	No	0	3	6
208	R:R:C228	R:R:Q229	1.53	No	No	0	6	5
209	R:R:M105	R:R:V100	1.52	No	No	0	6	3
210	R:R:I213	R:R:T212	1.52	No	No	0	7	3
211	R:R:I287	R:R:T291	1.52	No	No	0	5	5
212	R:R:M149	R:R:T146	1.51	No	No	0	3	7
213	R:R:L133	R:R:V144	1.49	No	No	0	5	4
214	R:R:L260	R:R:V256	1.49	No	No	0	4	6
215	R:R:I115	R:R:I162	1.47	No	No	0	5	3
216	R:R:I237	R:R:K226	1.45	No	No	0	7	4
217	R:R:I242	R:R:L239	1.43	No	No	0	5	8
218	R:R:K201	R:R:L205	1.41	No	No	0	4	5
219	R:R:E305	R:R:K308	1.35	No	No	0	4	8
220	R:R:L96	R:R:Q98	1.33	No	No	0	4	4
221	R:R:A164	R:R:Y118	1.33	No	Yes	0	5	7
222	R:R:F46	R:R:V47	1.31	Yes	No	0	7	6
223	R:R:H223	R:R:K226	1.31	No	No	0	3	4
224	R:R:F302	R:R:V298	1.31	No	No	0	6	6
225	R:R:R148	R:R:T151	1.29	No	No	0	4	3
226	R:R:H231	R:R:N232	1.28	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F46	4.0525	4	0	7
2	R:R:N53	6.61	4	0	9
3	R:R:I57	3.72	4	5	7
4	R:R:I69	5.662	5	2	6
5	R:R:Y73	6.04333	6	2	7
6	R:R:D81	7.0025	4	1	9
7	R:R:F84	6.425	4	1	6
8	R:R:F88	7.81	4	1	7
9	R:R:Y113	7.33333	6	1	6
10	R:R:Y118	5.212	5	0	7
11	R:R:M121	5.9425	4	1	7
12	R:R:F123	7.982	5	3	8
13	R:R:Y132	6.192	5	6	8
14	R:R:R145	7.5425	4	2	7
15	R:R:W158	7.06	4	3	9
16	R:R:L207	6.7975	4	1	8
17	R:R:P210	4.7275	4	0	9
18	R:R:F211	5.062	5	1	7
19	R:R:F214	6.93	5	1	8
20	R:R:C217	4.48	4	0	7
21	R:R:Y218	7.43833	6	1	9
22	R:R:F250	7.31	4	0	8
23	R:R:W251	8.405	6	1	9
24	R:R:F254	6.946	5	1	7
25	R:R:F290	9.0225	4	1	7
26	R:R:C293	5.3375	4	1	8
27	R:R:N296	9.0425	4	1	9
28	R:R:Y300	6.19	5	0	9
29	R:R:F307	8.54	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F46	R:R:V85	14.0069	5.24	Yes	No	0	7	6
2	R:R:S49	R:R:V85	16.468	8.08	No	No	0	8	6
3	R:R:C294	R:R:S49	19.5155	6.89	No	No	0	7	8
4	R:R:C294	R:R:L45	12.9206	4.76	No	No	0	7	7
5	R:R:N53	R:R:S49	37.6658	4.47	Yes	No	0	9	8
6	R:R:D81	R:R:N53	49.8173	8.08	Yes	Yes	0	9	9
7	R:R:D81	R:R:L77	21.9958	4.07	Yes	No	0	9	9
8	R:R:L77	R:R:Y300	22.8129	3.52	No	Yes	0	9	9
9	R:R:M127	R:R:Y300	100	8.38	No	Yes	0	9	9
10	R:R:M127	R:R:Y73	98.8464	4.79	No	Yes	0	9	7
11	R:R:I69	R:R:Y73	66.5353	9.67	Yes	Yes	2	6	7
12	R:R:I69	R:R:S68	60.4788	3.1	Yes	No	0	6	7
13	R:R:D71	R:R:S68	56.8064	2.94	No	No	0	8	7
14	R:R:D71	R:R:L60	47.5774	4.07	No	No	0	8	7
15	R:R:D81	R:R:N296	28.7541	8.08	Yes	Yes	1	9	9
16	R:R:N296	R:R:Y300	65.2855	5.81	Yes	Yes	0	9	9
17	R:R:L60	R:R:V56	26.0623	2.98	No	No	4	7	9
18	R:R:L60	R:R:L74	19.5347	4.15	No	No	4	7	8
19	R:R:A78	R:R:V56	24.9471	3.39	No	No	0	9	9
20	R:R:A78	R:R:I57	22.7745	3.25	No	Yes	0	9	7
21	R:R:I57	R:R:L75	16.0738	5.71	Yes	No	5	7	6
22	R:R:A301	R:R:F307	16.1315	8.32	No	Yes	0	7	8
23	R:R:A301	R:R:L74	18.3619	3.15	No	No	0	7	8
24	R:R:L66	R:R:L75	13.8916	4.15	No	No	0	6	6
25	R:R:L66	R:R:V72	11.6228	2.98	No	No	0	6	6
26	R:R:L126	R:R:Y73	24.9471	7.03	No	Yes	2	7	7
27	R:R:F123	R:R:V157	20.8421	10.49	Yes	No	0	8	6
28	R:R:L126	R:R:V157	23.0533	2.98	No	No	0	7	6
29	R:R:F112	R:R:S87	14.3338	2.64	No	No	0	5	7
30	R:R:S87	R:R:Y113	25.2644	5.09	No	Yes	0	7	6
31	R:R:F84	R:R:Y113	17.7947	9.28	Yes	Yes	1	6	6
32	R:R:C293	R:R:F84	25.1298	6.98	Yes	Yes	1	8	6
33	R:R:F290	R:R:F88	12.0842	16.08	Yes	Yes	1	7	7
34	R:R:E286	R:R:Y113	14.2184	5.61	No	Yes	1	5	6
35	R:R:F117	R:R:W251	14.2569	5.01	No	Yes	1	8	9
36	R:R:H292	R:R:W251	33.8396	22.22	No	Yes	0	9	9
37	R:R:H292	R:R:N296	35.5605	19.13	No	Yes	0	9	9
38	R:R:F117	R:R:Y118	17.0929	11.35	No	Yes	0	8	7
39	R:R:M121	R:R:P210	13.2186	3.35	Yes	Yes	0	7	9
40	R:R:F214	R:R:I124	34.8779	5.02	Yes	No	0	8	8
41	R:R:I124	R:R:Y300	35.3105	6.04	No	Yes	0	8	9
42	R:R:F214	R:R:S128	43.8954	3.96	Yes	No	1	8	9
43	R:R:R131	R:R:Y300	42.7322	7.2	No	Yes	0	9	9
44	R:R:R131	R:R:Y218	42.213	8.23	No	Yes	0	9	9
45	R:R:S128	R:R:Y218	27.3601	5.09	No	Yes	1	9	9
46	R:R:C217	R:R:S128	68.6022	5.16	Yes	No	0	7	9
47	R:R:C217	R:R:Y132	57.7581	9.41	Yes	Yes	0	7	8
48	R:R:L133	R:R:Y132	11.9785	3.52	No	Yes	0	5	8
49	R:R:V136	R:R:Y132	35.8104	10.09	No	Yes	6	7	8
50	R:R:Q224	R:R:V136	33.0033	5.73	No	No	0	5	7
51	R:R:Q224	R:R:V135	27.1102	2.87	No	No	0	5	8
52	R:R:L225	R:R:V135	24.1396	2.98	No	No	0	8	8
53	R:R:F211	R:R:W251	29.004	6.01	Yes	Yes	1	7	9
54	R:R:F211	R:R:L207	17.6408	2.44	Yes	Yes	1	7	8
55	R:R:L207	R:R:N203	11.8727	4.12	Yes	No	1	8	6
56	R:R:V244	R:R:Y218	10.6133	5.05	No	Yes	1	8	9
57	R:R:V240	R:R:Y218	19.0829	8.83	No	Yes	0	7	9
58	R:R:L222	R:R:V240	14.7279	5.96	No	No	0	5	7
59	R:R:I237	R:R:L222	12.3149	4.28	No	No	0	7	5
60	R:R:C228	R:R:L225	18.4484	1.59	No	No	0	6	8
61	R:R:F250	R:R:H292	27.014	13.58	Yes	No	0	8	9
62	R:R:F250	R:R:V295	20.8998	7.87	Yes	No	0	8	6
63	R:R:I299	R:R:V295	18.8233	3.07	No	No	0	8	6
64	R:R:I242	R:R:I299	16.7083	2.94	No	No	0	5	8
65	R:R:I242	R:R:L239	14.9875	1.43	No	No	0	5	8
66	R:R:K235	R:R:L239	10.6999	4.23	No	No	0	7	8
67	R:R:F254	R:R:W251	28.235	3.01	Yes	Yes	1	7	9
68	R:R:C293	R:R:N296	24.4088	3.15	Yes	Yes	1	8	9
69	R:R:E286	R:R:F254	22.14	7	No	Yes	1	5	7
70	R:R:F211	R:R:F214	39.9635	5.36	Yes	Yes	1	7	8
71	R:R:F211	R:R:M121	11.9208	6.22	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XML_nogp

PDB Summary
PDB	8XML_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	202
Number of Links	226
Number of Hubs	29
Number of Links mediated by Hubs	110
Number of Communities	6
Number of Nodes involved in Communities	48
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	24869
Length Of Smallest Path	3
Average Path Length	12.0331
Length of Longest Path	28
Minimum Path Strength	1.38
Average Path Strength	6.22218
Maximum Path Strength	20.675
Minimum Path Correlation	0.7
Average Path Correlation	0.915423
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.2541
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1867
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • coreceptor activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • protein binding • chemokine binding • cytokine binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • cellular response to chemical stimulus • cell migration • cell motility • immune response • immune system process • cell adhesion • regulation of biological process • regulation of cellular process • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cellular anatomical structure • periplasmic space • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51685
Sequence	>8XML_nogp_Chain_R V F Y C L L F V F S L L G N S L V I L V L V V C K K L R S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D Q W V F G T V M C K V V S G F Y Y I G F Y S S M F I T L M S V D R Y L A V V H A V Y A L K V R T I R M G T T L C L A V W L T A I M A T I P L C Y T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C Q N H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S T E I I S F T H C C V N P V I Y A F V G E K F K K H L W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TLM	A	Protein	Chemokine	CCR8	Homo sapiens	Anti-murine CCR8 antibody	-	-	3.9	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-	Gi1/β1/γ2	3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8U1U (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-		3.1	2023-12-20	doi.org/10.1038/s41467-023-43601-8
	8KFX	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-	Gi1/β1/γ2	2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFX (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-		2.96	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-	Gi1/β1/γ2	3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFY (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-		3.06	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8KFZ (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		3.3	2024-02-07	doi.org/10.1126/sciadv.adj7500
	8XML	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	2.58	2025-01-01	To be published
	8XML (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		2.58	2025-01-01	To be published

there is no ligand in network 8XML_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.