psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K24	R:R:E28	6.75	No	No	0	0	2
2	L:L:K24	R:R:Y94	7.17	No	No	0	0	5
3	L:L:S25	R:R:Q91	8.66	No	No	0	0	6
4	L:L:S25	R:R:E286	8.62	No	No	0	0	5
5	L:L:M26	R:R:Y113	4.79	No	No	0	0	6
6	L:L:M26	R:R:C183	4.86	No	No	0	0	9
7	L:L:Q27	R:R:Y114	5.64	No	Yes	1	0	5
8	L:L:Q27	R:R:M202	4.08	No	Yes	1	0	5
9	L:L:Q27	R:R:L258	5.32	No	No	0	0	5
10	L:L:V28	R:R:T282	4.76	No	No	0	0	4
11	L:L:I56	L:L:P29	8.47	Yes	Yes	2	0	0
12	L:L:P29	R:R:Q182	4.74	Yes	Yes	2	0	4
13	L:L:P29	R:R:Y184	16.69	Yes	Yes	2	0	2
14	L:L:F30	L:L:R32	4.28	Yes	Yes	2	0	0
15	L:L:F30	R:R:E28	9.33	Yes	No	0	0	2
16	L:L:F30	R:R:V180	3.93	Yes	No	2	0	3
17	L:L:F30	R:R:Q182	4.68	Yes	Yes	2	0	4
18	L:L:R32	L:L:R51	5.33	Yes	Yes	2	0	0
19	L:L:E71	L:L:R32	10.47	No	Yes	2	0	0
20	L:L:R32	R:R:P24	7.21	Yes	Yes	2	0	5
21	L:L:R32	R:R:D26	13.1	Yes	No	0	0	3
22	L:L:R32	R:R:D178	11.91	Yes	No	2	0	2
23	L:L:C33	L:L:F35	9.78	No	Yes	0	0	0
24	L:L:C33	L:L:C57	7.28	No	No	0	0	0
25	L:L:C34	L:L:C73	7.28	No	No	0	0	0
26	L:L:F35	L:L:N59	6.04	Yes	No	0	0	0
27	L:L:F35	R:R:C25	5.59	Yes	No	9	0	9
28	L:L:F35	R:R:C272	6.98	Yes	No	9	0	8
29	L:L:F35	R:R:S275	5.28	Yes	No	0	0	1
30	L:L:S36	R:R:S22	6.52	No	No	0	0	3
31	L:L:F37	L:L:L75	4.87	No	No	0	0	0
32	L:L:D76	L:L:F37	3.58	No	No	0	0	0
33	L:L:C38	R:R:I20	6.55	No	Yes	0	0	3
34	L:L:C38	R:R:C21	7.28	No	No	0	0	3
35	L:L:Q40	R:R:I20	6.86	No	Yes	0	0	3
36	L:L:E41	L:L:W80	6.54	No	Yes	0	0	0
37	L:L:H84	L:L:L44	6.43	Yes	No	0	0	0
38	L:L:I47	L:L:K67	4.36	No	No	0	0	0
39	L:L:L48	L:L:L88	8.3	No	No	0	0	0
40	L:L:C49	L:L:C91	7.28	No	No	0	0	0
41	L:L:L62	L:L:Y50	9.38	Yes	No	3	0	0
42	L:L:R85	L:L:Y50	8.23	Yes	No	3	0	0
43	L:L:H90	L:L:Y50	8.71	No	No	0	0	0
44	L:L:I63	L:L:R51	3.76	Yes	Yes	2	0	0
45	L:L:R51	R:R:D178	10.72	Yes	No	2	0	2
46	L:L:I56	L:L:S54	4.64	Yes	No	0	0	0
47	L:L:S55	R:R:T191	7.99	No	No	0	0	3
48	L:L:I56	R:R:Y184	6.04	Yes	Yes	2	0	2
49	L:L:I56	R:R:T191	6.08	Yes	No	0	0	3
50	L:L:S58	R:R:L192	7.51	No	No	0	0	1
51	L:L:S58	R:R:H267	4.18	No	No	0	0	1
52	L:L:N59	R:R:D270	4.04	No	No	0	0	1
53	L:L:G61	L:L:T77	3.64	No	No	0	0	0
54	L:L:F64	L:L:L62	3.65	No	Yes	3	0	0
55	L:L:L62	L:L:V81	4.47	Yes	Yes	3	0	0
56	L:L:L62	L:L:R85	4.86	Yes	Yes	3	0	0
57	L:L:E71	L:L:I63	4.1	No	Yes	2	0	0
58	L:L:I63	R:R:P24	6.77	Yes	Yes	2	0	5
59	L:L:F64	L:L:W80	4.01	No	Yes	3	0	0
60	L:L:F64	L:L:V81	5.24	No	Yes	3	0	0
61	L:L:K67	L:L:R68	11.14	No	No	0	0	0
62	L:L:E71	R:R:P24	9.43	No	Yes	2	0	5
63	L:L:A72	R:R:I20	4.87	No	Yes	0	0	3
64	L:L:R85	L:L:T77	5.17	Yes	No	0	0	0
65	L:L:V81	L:L:W80	8.58	Yes	Yes	3	0	0
66	L:L:H84	L:L:W80	8.46	Yes	Yes	0	0	0
67	L:L:Q82	L:L:R85	7.01	No	Yes	0	0	0
68	R:R:C21	R:R:S22	5.16	No	No	0	3	3
69	R:R:P24	R:R:S23	3.56	Yes	No	0	5	5
70	R:R:C25	R:R:C272	7.28	No	No	9	9	8
71	R:R:L29	R:R:Q276	6.65	No	No	0	2	3
72	R:R:I30	R:R:K35	7.27	No	No	0	1	4
73	R:R:N33	R:R:Q31	3.96	No	No	0	2	2
74	R:R:K35	R:R:L95	7.05	No	No	0	4	5
75	R:R:A39	R:R:L96	4.73	No	No	0	5	4
76	R:R:F41	R:R:I287	3.77	No	No	0	4	5
77	R:R:Q91	R:R:Y42	12.4	No	Yes	0	6	7
78	R:R:T92	R:R:Y42	3.75	No	Yes	0	7	7
79	R:R:I287	R:R:Y42	12.09	No	Yes	0	5	7
80	R:R:F290	R:R:Y42	5.16	Yes	Yes	0	7	7
81	R:R:F46	R:R:F88	7.5	No	Yes	0	7	7
82	R:R:F46	R:R:P89	7.22	No	No	0	7	8
83	R:R:N53	R:R:S49	4.47	No	No	0	9	8
84	R:R:S49	R:R:V85	6.46	No	No	0	8	6
85	R:R:D81	R:R:N53	10.77	Yes	No	0	9	9
86	R:R:N53	R:R:P297	6.52	No	No	0	9	9
87	R:R:I57	R:R:L75	4.28	Yes	Yes	0	7	6
88	R:R:I57	R:R:L79	4.28	Yes	No	0	7	6
89	R:R:C63	R:R:V59	5.12	Yes	No	0	5	7
90	R:R:F307	R:R:V59	3.93	Yes	No	6	8	7
91	R:R:L311	R:R:V59	4.47	Yes	No	6	6	7
92	R:R:L60	R:R:L74	4.15	No	No	0	7	8
93	R:R:L60	R:R:L75	5.54	No	Yes	0	7	6
94	R:R:C63	R:R:H310	5.9	Yes	No	0	5	4
95	R:R:D71	R:R:K64	4.15	No	No	0	8	5
96	R:R:H310	R:R:K64	15.72	No	No	0	4	5
97	R:R:K65	R:R:R67	3.71	No	No	0	6	6
98	R:R:L66	R:R:L75	5.54	No	Yes	0	6	6
99	R:R:S68	R:R:T70	6.4	No	No	0	7	8
100	R:R:D71	R:R:S68	4.42	No	No	0	8	7
101	R:R:I69	R:R:Y73	10.88	No	Yes	7	6	7
102	R:R:D130	R:R:I69	4.2	Yes	No	7	8	6
103	R:R:I69	R:R:R145	3.76	No	Yes	7	6	7
104	R:R:D130	R:R:T70	4.34	Yes	No	0	8	8
105	R:R:D71	R:R:K306	5.53	No	No	0	8	6
106	R:R:L126	R:R:Y73	4.69	No	Yes	0	7	7
107	R:R:M127	R:R:Y73	4.79	No	Yes	0	9	7
108	R:R:D130	R:R:Y73	9.2	Yes	Yes	7	8	7
109	R:R:G150	R:R:Y73	4.35	No	Yes	0	7	7
110	R:R:F123	R:R:N76	9.67	Yes	No	5	8	9
111	R:R:C154	R:R:N76	7.87	No	No	5	7	9
112	R:R:D81	R:R:L77	5.43	Yes	No	1	9	9
113	R:R:L77	R:R:N296	5.49	No	No	1	9	9
114	R:R:S119	R:R:S80	6.52	Yes	No	0	7	8
115	R:R:D81	R:R:S120	4.42	Yes	No	1	9	9
116	R:R:D81	R:R:H292	5.04	Yes	Yes	1	9	9
117	R:R:C293	R:R:D81	4.67	No	Yes	1	8	9
118	R:R:D81	R:R:N296	6.73	Yes	No	1	9	9
119	R:R:F112	R:R:L83	6.09	No	No	0	5	6
120	R:R:F84	R:R:F88	4.29	Yes	Yes	1	6	7
121	R:R:F84	R:R:Y113	9.28	Yes	No	0	6	6
122	R:R:F84	R:R:G116	4.52	Yes	No	0	6	8
123	R:R:F290	R:R:F84	7.5	Yes	Yes	1	7	6
124	R:R:F84	R:R:H292	6.79	Yes	Yes	1	6	9
125	R:R:C293	R:R:F84	5.59	No	Yes	1	8	6
126	R:R:F88	R:R:V85	11.8	Yes	No	0	7	6
127	R:R:F290	R:R:F88	20.36	Yes	Yes	1	7	7
128	R:R:F90	R:R:P89	4.33	No	No	0	6	8
129	R:R:F101	R:R:F90	8.57	Yes	No	0	7	6
130	R:R:F90	R:R:V109	11.8	No	No	0	6	5
131	R:R:D97	R:R:Y93	13.79	No	No	0	4	2
132	R:R:V100	R:R:Y93	7.57	No	No	4	3	2
133	R:R:F101	R:R:Y93	6.19	Yes	No	4	7	2
134	R:R:W99	R:R:Y94	10.61	Yes	No	0	9	5
135	R:R:Q182	R:R:Y94	4.51	Yes	No	0	4	5
136	R:R:D97	R:R:Q98	5.22	No	No	0	4	4
137	R:R:L181	R:R:Q98	11.98	No	No	0	4	4
138	R:R:F101	R:R:W99	19.04	Yes	Yes	4	7	9
139	R:R:C106	R:R:W99	3.92	No	Yes	4	9	9
140	R:R:V109	R:R:W99	6.13	No	Yes	0	5	9
141	R:R:V174	R:R:W99	3.68	No	Yes	0	5	9
142	R:R:C183	R:R:W99	15.67	No	Yes	4	9	9
143	R:R:F101	R:R:V100	3.93	Yes	No	4	7	3
144	R:R:T103	R:R:V174	4.76	No	No	0	2	5
145	R:R:C106	R:R:C183	7.28	No	No	4	9	9
146	R:R:F112	R:R:V108	6.55	No	No	0	5	5
147	R:R:S110	R:R:Y172	10.17	No	No	0	5	4
148	R:R:Y113	R:R:Y114	12.91	No	Yes	0	6	5
149	R:R:T165	R:R:Y114	3.75	No	Yes	0	7	5
150	R:R:L168	R:R:Y114	12.89	No	Yes	0	4	5
151	R:R:Y114	R:R:Y172	10.92	Yes	No	0	5	4
152	R:R:M202	R:R:Y114	3.59	Yes	Yes	1	5	5
153	R:R:I115	R:R:I162	4.42	No	No	0	5	3
154	R:R:I115	R:R:T165	10.64	No	No	0	5	7
155	R:R:F117	R:R:Y118	10.32	Yes	Yes	1	8	7
156	R:R:F117	R:R:M121	3.73	Yes	Yes	1	8	7
157	R:R:F117	R:R:M202	8.71	Yes	Yes	1	8	5
158	R:R:F117	R:R:W251	6.01	Yes	Yes	1	8	9
159	R:R:F122	R:R:Y118	6.19	Yes	Yes	1	5	7
160	R:R:A164	R:R:Y118	8.01	No	Yes	0	5	7
161	R:R:K201	R:R:Y118	5.97	No	Yes	0	4	7
162	R:R:M202	R:R:Y118	3.59	Yes	Yes	1	5	7
163	R:R:L205	R:R:Y118	5.86	No	Yes	1	5	7
164	R:R:F123	R:R:S119	3.96	Yes	Yes	5	8	7
165	R:R:S119	R:R:W158	6.18	Yes	No	5	7	9
166	R:R:H292	R:R:S120	5.58	Yes	No	1	9	9
167	R:R:G206	R:R:M121	5.24	No	Yes	0	5	7
168	R:R:F211	R:R:M121	3.73	Yes	Yes	1	7	7
169	R:R:M121	R:R:W251	9.31	Yes	Yes	1	7	9
170	R:R:F122	R:R:V157	6.55	Yes	No	0	5	6
171	R:R:F122	R:R:T160	3.89	Yes	No	0	5	4
172	R:R:F122	R:R:L205	6.09	Yes	No	1	5	5
173	R:R:C154	R:R:F123	4.19	No	Yes	5	7	8
174	R:R:F123	R:R:V157	14.42	Yes	No	0	8	6
175	R:R:F123	R:R:W158	12.03	Yes	No	5	8	9
176	R:R:I124	R:R:Y300	4.84	No	Yes	0	8	9
177	R:R:I213	R:R:T125	6.08	No	No	0	7	7
178	R:R:M127	R:R:Y300	3.59	No	Yes	0	9	9
179	R:R:F214	R:R:S128	6.61	Yes	No	8	8	9
180	R:R:C217	R:R:S128	6.89	No	No	0	7	9
181	R:R:S128	R:R:Y218	5.09	No	Yes	8	9	9
182	R:R:D130	R:R:R145	15.48	Yes	Yes	7	8	7
183	R:R:R131	R:R:Y218	12.35	No	Yes	0	9	9
184	R:R:R131	R:R:Y300	6.17	No	Yes	0	9	9
185	R:R:V136	R:R:Y132	12.62	No	Yes	0	7	8
186	R:R:H137	R:R:Y132	8.71	No	Yes	0	6	8
187	R:R:C217	R:R:Y132	5.38	No	Yes	0	7	8
188	R:R:K220	R:R:Y132	5.97	No	Yes	0	4	8
189	R:R:L133	R:R:V144	4.47	No	No	0	5	4
190	R:R:A134	R:R:R145	6.91	No	Yes	0	8	7
191	R:R:V144	R:R:Y140	6.31	No	No	0	4	4
192	R:R:L168	R:R:T198	7.37	No	No	0	4	6
193	R:R:F171	R:R:V170	3.93	No	No	0	4	3
194	R:R:F171	R:R:W194	27.06	No	Yes	0	4	2
195	R:R:Y172	R:R:Y184	4.96	No	Yes	0	4	2
196	R:R:A175	R:R:E177	4.53	No	No	2	1	1
197	R:R:A175	R:R:F186	9.71	No	Yes	2	1	4
198	R:R:L181	R:R:S176	4.5	No	No	0	4	3
199	R:R:E177	R:R:Q182	5.1	No	Yes	2	1	4
200	R:R:E177	R:R:F186	7	No	Yes	2	1	4
201	R:R:Q182	R:R:V180	5.73	Yes	No	2	4	3
202	R:R:F186	R:R:Q182	7.03	Yes	Yes	2	4	4
203	R:R:S185	R:R:Y184	8.9	No	Yes	0	4	2
204	R:R:F186	R:R:Y184	4.13	Yes	Yes	2	4	2
205	R:R:K195	R:R:Y184	4.78	Yes	Yes	2	5	2
206	R:R:S185	R:R:W194	4.94	No	Yes	0	4	2
207	R:R:F186	R:R:T191	6.49	Yes	No	0	4	3
208	R:R:W194	R:R:Y187	3.86	Yes	No	0	2	5
209	R:R:N188	R:R:Q190	5.28	No	No	0	3	4
210	R:R:Q190	R:R:W194	8.76	No	Yes	0	4	2
211	R:R:K193	R:R:W194	4.64	No	Yes	0	2	2
212	R:R:K195	R:R:N199	8.39	Yes	Yes	2	5	5
213	R:R:K195	R:R:T261	6.01	Yes	No	2	5	4
214	R:R:K195	R:R:S265	9.18	Yes	No	0	5	3
215	R:R:I196	R:R:S262	4.64	No	No	0	3	5
216	R:R:I196	R:R:S265	4.64	No	No	0	3	3
217	R:R:I196	R:R:M266	5.83	No	No	0	3	3
218	R:R:F197	R:R:K201	8.69	No	No	0	4	4
219	R:R:N199	R:R:T198	4.39	Yes	No	0	5	6
220	R:R:N199	R:R:T261	4.39	Yes	No	2	5	4
221	R:R:N199	R:R:S262	5.96	Yes	No	0	5	5
222	R:R:F200	R:R:F259	4.29	No	No	0	5	6
223	R:R:F200	R:R:S262	10.57	No	No	0	5	5
224	R:R:F200	R:R:M266	4.98	No	No	0	5	3
225	R:R:N203	R:R:N255	4.09	No	No	0	6	8
226	R:R:F259	R:R:N203	6.04	No	No	0	6	6
227	R:R:G206	R:R:P210	4.06	No	No	0	5	9
228	R:R:F211	R:R:L207	6.09	Yes	No	0	7	8
229	R:R:L207	R:R:N255	9.61	No	No	0	8	8
230	R:R:F211	R:R:L248	6.09	Yes	No	0	7	6
231	R:R:F211	R:R:W251	7.02	Yes	Yes	1	7	9
232	R:R:F214	R:R:M215	3.73	Yes	No	0	8	4
233	R:R:F214	R:R:Y218	13.41	Yes	Yes	8	8	9
234	R:R:F214	R:R:V244	5.24	Yes	No	8	8	8
235	R:R:F214	R:R:S247	7.93	Yes	No	0	8	9
236	R:R:L248	R:R:M215	4.24	No	No	0	6	4
237	R:R:F216	R:R:K220	8.69	No	No	0	4	4
238	R:R:V240	R:R:Y218	5.05	No	Yes	0	7	9
239	R:R:V244	R:R:Y218	5.05	No	Yes	8	8	9
240	R:R:I237	R:R:L222	4.28	No	No	0	7	5
241	R:R:L222	R:R:V240	4.47	No	No	0	5	7
242	R:R:L222	R:R:L241	4.15	No	No	0	5	5
243	R:R:K233	R:R:L225	4.23	No	No	0	6	8
244	R:R:I237	R:R:L225	5.71	No	No	0	7	8
245	R:R:C228	R:R:K233	6.47	No	No	0	6	6
246	R:R:H231	R:R:K233	5.24	No	No	0	3	6
247	R:R:K235	R:R:L239	7.05	No	No	0	7	8
248	R:R:E305	R:R:K235	6.75	No	No	0	4	7
249	R:R:L239	R:R:V303	4.47	No	No	0	8	7
250	R:R:I299	R:R:V243	7.68	No	No	1	8	8
251	R:R:V243	R:R:Y300	3.79	No	Yes	1	8	9
252	R:R:A246	R:R:F250	4.16	No	Yes	0	6	8
253	R:R:L248	R:R:V252	4.47	No	No	0	6	5
254	R:R:F250	R:R:W251	9.02	Yes	Yes	1	8	9
255	R:R:F250	R:R:T291	3.89	Yes	No	0	8	5
256	R:R:F250	R:R:H292	4.53	Yes	Yes	1	8	9
257	R:R:F250	R:R:V295	3.93	Yes	No	0	8	6
258	R:R:S289	R:R:W251	4.94	No	Yes	0	8	9
259	R:R:H292	R:R:W251	19.04	Yes	Yes	1	9	9
260	R:R:F254	R:R:L258	14.61	No	No	0	7	5
261	R:R:F254	R:R:T285	7.78	No	No	0	7	6
262	R:R:F254	R:R:S289	10.57	No	No	0	7	8
263	R:R:T285	R:R:V257	7.93	No	No	0	6	5
264	R:R:F259	R:R:L263	12.18	No	No	0	6	4
265	R:R:L278	R:R:T261	4.42	No	No	0	5	4
266	R:R:I268	R:R:L263	7.14	No	No	0	1	4
267	R:R:H264	R:R:S275	6.97	No	No	0	2	1
268	R:R:I268	R:R:M266	4.37	No	No	0	1	3
269	R:R:I274	R:R:L269	4.28	No	No	0	3	2
270	R:R:V284	R:R:Y280	5.05	No	No	0	6	3
271	R:R:E286	R:R:F290	12.83	No	Yes	0	5	7
272	R:R:C293	R:R:H292	10.32	No	Yes	1	8	9
273	R:R:N296	R:R:Y300	6.98	No	Yes	1	9	9
274	R:R:I299	R:R:Y300	7.25	No	Yes	1	8	9
275	R:R:A301	R:R:F307	8.32	No	Yes	0	7	8
276	R:R:F302	R:R:F307	5.36	No	Yes	6	6	8
277	R:R:F302	R:R:L311	3.65	No	Yes	6	6	6
278	R:R:E305	R:R:K308	9.45	No	No	0	4	8
279	R:R:F307	R:R:L311	10.96	Yes	Yes	6	8	6
280	L:L:P29	L:L:V28	3.53	Yes	No	0	0	0
281	R:R:P297	R:R:V56	3.53	No	No	0	9	9
282	R:R:P253	R:R:V252	3.53	No	No	0	9	5
283	L:L:E39	L:L:F37	3.5	No	No	0	0	0
284	R:R:P210	R:R:T125	3.5	No	No	0	9	7
285	L:L:C33	L:L:S31	3.44	No	No	0	0	0
286	L:L:C73	R:R:S22	3.44	No	No	0	0	3
287	R:R:C63	R:R:V62	3.42	Yes	No	0	5	5
288	R:R:C217	R:R:V129	3.42	No	No	0	7	6
289	L:L:H90	L:L:R51	3.39	No	Yes	0	0	0
290	L:L:A74	L:L:V81	3.39	No	Yes	0	0	0
291	R:R:A78	R:R:V56	3.39	No	No	0	9	9
292	R:R:I166	R:R:P167	3.39	No	No	0	4	8
293	R:R:I209	R:R:P210	3.39	No	No	0	6	9
294	L:L:C57	L:L:T53	3.38	No	No	0	0	0
295	L:L:C34	L:L:I63	3.27	No	Yes	0	0	0
296	R:R:C63	R:R:I314	3.27	Yes	No	0	5	4
297	L:L:S31	L:L:S54	3.26	No	No	0	0	0
298	L:L:S58	R:R:S265	3.26	No	No	0	0	3
299	R:R:A78	R:R:I57	3.25	No	Yes	0	9	7
300	R:R:V135	R:R:V136	3.21	No	No	10	8	7
301	L:L:V28	R:R:T279	3.17	No	No	0	0	4
302	L:L:C34	L:L:L75	3.17	No	No	0	0	0
303	R:R:C294	R:R:L45	3.17	No	No	0	7	7
304	L:L:A46	L:L:L48	3.15	No	No	0	0	0
305	R:R:A236	R:R:L225	3.15	No	No	0	7	8
306	R:R:I147	R:R:V72	3.07	No	No	0	3	6
307	R:R:I221	R:R:V135	3.07	No	No	0	8	8
308	R:R:M105	R:R:V108	3.04	No	No	0	6	5
309	L:L:F35	R:R:G271	3.01	Yes	No	0	0	3
310	R:R:L50	R:R:S54	3	No	No	0	6	4
311	R:R:L75	R:R:V61	2.98	Yes	No	0	6	4
312	R:R:L66	R:R:V72	2.98	No	No	0	6	6
313	R:R:L36	R:R:T32	2.95	No	No	0	4	2
314	R:R:L45	R:R:T291	2.95	No	No	0	7	5
315	R:R:I162	R:R:I166	2.94	No	No	0	3	4
316	L:L:D76	L:L:V78	2.92	No	No	0	0	0
317	R:R:I219	R:R:M215	2.92	No	No	0	4	4
318	L:L:K70	R:R:I20	2.91	No	Yes	0	0	3
319	R:R:Q224	R:R:V135	2.87	No	No	10	5	8
320	R:R:Q224	R:R:V136	2.87	No	No	10	5	7
321	R:R:I287	R:R:L38	2.85	No	No	0	5	6
322	R:R:I57	R:R:L82	2.85	Yes	No	0	7	7
323	R:R:I115	R:R:L83	2.85	No	No	0	5	6
324	R:R:I204	R:R:L208	2.85	No	No	0	5	4
325	R:R:I245	R:R:L249	2.85	No	No	0	5	6
326	R:R:I274	R:R:L278	2.85	No	No	0	3	5
327	R:R:G102	R:R:W99	2.81	No	Yes	0	8	9
328	L:L:S25	R:R:H283	2.79	No	No	0	0	4
329	R:R:L38	R:R:L95	2.77	No	No	0	6	5
330	R:R:L311	R:R:L55	2.77	Yes	No	0	6	6
331	R:R:L126	R:R:L153	2.77	No	No	0	7	6
332	R:R:A141	R:R:R145	2.77	No	Yes	0	6	7
333	L:L:L62	L:L:N52	2.75	Yes	No	0	0	0
334	R:R:E313	R:R:I314	2.73	No	No	0	5	4
335	R:R:K226	R:R:Q229	2.71	No	No	0	4	5
336	R:R:F88	R:R:S87	2.64	Yes	No	0	7	7
337	R:R:F48	R:R:V47	2.62	No	No	0	5	6
338	R:R:R148	R:R:T152	2.59	No	No	0	4	3
339	L:L:H84	L:L:L88	2.57	Yes	No	0	0	0
340	R:R:I242	R:R:R238	2.51	No	No	0	5	6
341	R:R:K235	R:R:R238	2.48	No	No	0	7	6
342	R:R:F48	R:R:L44	2.44	No	No	0	5	5
343	R:R:F46	R:R:L50	2.44	No	No	0	7	6
344	R:R:L133	R:R:R145	2.43	No	Yes	0	5	7
345	R:R:Q224	R:R:R227	2.34	No	No	0	5	5
346	L:L:C91	L:L:P92	1.88	No	No	0	0	0
347	L:L:S93	R:R:G179	1.86	No	No	0	0	4
348	R:R:G111	R:R:S110	1.86	No	No	0	5	5
349	R:R:G179	R:R:S176	1.86	No	No	0	4	3
350	L:L:G79	L:L:V78	1.84	No	No	0	0	0
351	R:R:G304	R:R:V303	1.84	No	No	0	8	7
352	R:R:G150	R:R:M149	1.75	No	No	0	7	3
353	L:L:S31	R:R:A27	1.71	No	No	0	0	3
354	R:R:G52	R:R:L51	1.71	No	No	0	8	4
355	R:R:G111	R:R:L169	1.71	No	No	0	5	4
356	R:R:A161	R:R:S119	1.71	No	Yes	0	8	7
357	R:R:G34	R:R:N33	1.7	No	No	0	4	2
358	R:R:A281	R:R:V257	1.7	No	No	0	5	5
359	R:R:C43	R:R:T92	1.69	No	No	0	4	7
360	L:L:E60	L:L:G61	1.64	No	No	0	0	0
361	L:L:A46	L:L:K67	1.61	No	No	0	0	0
362	R:R:V104	R:R:V108	1.6	No	No	0	4	5
363	R:R:V295	R:R:V298	1.6	No	No	0	6	6
364	R:R:T151	R:R:V72	1.59	No	No	0	3	6
365	R:R:T285	R:R:V284	1.59	No	No	0	6	6
366	R:R:I274	R:R:S273	1.55	No	No	0	3	1
367	R:R:C25	R:R:Q276	1.53	No	No	0	9	3
368	R:R:K143	R:R:V144	1.52	No	No	0	5	4
369	R:R:I288	R:R:T291	1.52	No	No	0	7	5
370	R:R:M149	R:R:T146	1.51	No	No	0	3	7
371	R:R:M163	R:R:T160	1.51	No	No	0	4	4
372	R:R:K107	R:R:T103	1.5	No	No	0	7	2
373	R:R:L37	R:R:V40	1.49	No	No	0	5	5
374	R:R:L51	R:R:V47	1.49	No	No	0	4	6
375	R:R:L58	R:R:V62	1.49	No	No	0	3	5
376	R:R:L260	R:R:V256	1.49	Yes	No	0	4	6
377	R:R:L155	R:R:T151	1.47	No	No	0	4	3
378	R:R:I204	R:R:I209	1.47	No	No	0	5	6
379	R:R:L208	R:R:T212	1.47	No	No	0	4	3
380	R:R:I242	R:R:I299	1.47	No	No	0	5	8
381	R:R:N33	R:R:T32	1.46	No	No	0	2	2
382	L:L:I47	L:L:K65	1.45	No	No	0	0	0
383	R:R:Q277	R:R:S273	1.44	No	No	0	3	1
384	R:R:K308	R:R:K309	1.44	No	No	0	8	5
385	L:L:L66	R:R:I20	1.43	No	Yes	0	0	3
386	R:R:Q173	R:R:T103	1.42	No	No	0	4	2
387	L:L:L88	L:L:M87	1.41	No	No	0	0	0
388	R:R:K35	R:R:L96	1.41	No	No	0	4	4
389	R:R:L44	R:R:L45	1.38	No	No	0	5	7
390	R:R:L260	R:R:L263	1.38	Yes	No	0	4	4
391	R:R:L260	R:R:L269	1.38	Yes	No	0	4	2
392	R:R:L260	R:R:L278	1.38	Yes	No	0	4	5
393	L:L:E41	L:L:I42	1.37	No	No	0	0	0
394	R:R:I237	R:R:Q229	1.37	No	No	0	7	5
395	L:L:P43	L:L:W80	1.35	No	Yes	0	0	0
396	R:R:N188	R:R:Q189	1.32	No	No	0	3	4
397	R:R:F41	R:R:V40	1.31	No	No	0	4	5
398	R:R:F86	R:R:V85	1.31	No	No	0	4	6
399	R:R:R148	R:R:T146	1.29	No	No	0	4	7
400	R:R:R238	R:R:T234	1.29	No	No	0	6	4
401	L:L:H84	L:L:R83	1.13	Yes	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P29	8.3575	4	2	0
2	L:L:F30	5.555	4	2	0
3	L:L:R32	8.71667	6	2	0
4	L:L:F35	6.11333	6	9	0
5	L:L:R51	5.8	4	2	0
6	L:L:I56	6.3075	4	2	0
7	L:L:L62	5.022	5	3	0
8	L:L:I63	4.475	4	2	0
9	L:L:W80	5.788	5	3	0
10	L:L:V81	5.42	4	3	0
11	L:L:H84	4.6475	4	0	0
12	L:L:R85	6.3175	4	3	0
13	R:R:I20	4.524	5	0	3
14	R:R:P24	6.7425	4	2	5
15	R:R:Y42	8.35	4	0	7
16	R:R:I57	3.665	4	0	7
17	R:R:C63	4.4275	4	0	5
18	R:R:Y73	6.782	5	7	7
19	R:R:L75	4.585	4	0	6
20	R:R:D81	6.17667	6	1	9
21	R:R:F84	6.32833	6	1	6
22	R:R:F88	9.318	5	1	7
23	R:R:W99	8.83714	7	4	9
24	R:R:F101	9.4325	4	4	7
25	R:R:Y114	8.28333	6	1	5
26	R:R:F117	7.1925	4	1	8
27	R:R:Y118	6.65667	6	1	7
28	R:R:S119	4.5925	4	5	7
29	R:R:M121	5.5025	4	1	7
30	R:R:F122	5.68	4	1	5
31	R:R:F123	8.854	5	5	8
32	R:R:D130	8.305	4	7	8
33	R:R:Y132	8.17	4	0	8
34	R:R:R145	6.27	5	7	7
35	R:R:Q182	5.29833	6	2	4
36	R:R:Y184	7.58333	6	2	2
37	R:R:F186	6.872	5	2	4
38	R:R:W194	9.852	5	0	2
39	R:R:K195	7.09	4	2	5
40	R:R:N199	5.7825	4	2	5
41	R:R:M202	4.9925	4	1	5
42	R:R:F211	5.7325	4	1	7
43	R:R:F214	7.384	5	8	8
44	R:R:Y218	8.19	5	8	9
45	R:R:F250	5.106	5	1	8
46	R:R:W251	9.22333	6	1	9
47	R:R:L260	1.4075	4	0	4
48	R:R:F290	11.4625	4	1	7
49	R:R:H292	8.55	6	1	9
50	R:R:Y300	5.43667	6	1	9
51	R:R:F307	7.1425	4	6	8
52	R:R:L311	5.4625	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W99	R:R:Y94	27.5493	10.61	Yes	No	0	9	5
2	R:R:C183	R:R:W99	26.4127	15.67	No	Yes	4	9	9
3	L:L:M26	R:R:C183	26.8679	4.86	No	No	0	0	9
4	L:L:M26	R:R:Y113	27.1121	4.79	No	No	0	0	6
5	R:R:F84	R:R:Y113	83.3688	9.28	Yes	No	0	6	6
6	R:R:F290	R:R:F84	11.7121	7.5	Yes	Yes	1	7	6
7	R:R:Y113	R:R:Y114	58.7315	12.91	No	Yes	0	6	5
8	R:R:Q182	R:R:Y94	27.0671	4.51	Yes	No	0	4	5
9	L:L:P29	R:R:Q182	40.6493	4.74	Yes	Yes	2	0	4
10	L:L:P29	R:R:Y184	39.5425	16.69	Yes	Yes	2	0	2
11	R:R:Y172	R:R:Y184	83.9636	4.96	No	Yes	0	4	2
12	R:R:Y114	R:R:Y172	84.198	10.92	Yes	No	0	5	4
13	R:R:F186	R:R:Q182	38.6196	7.03	Yes	Yes	2	4	4
14	R:R:F186	R:R:Y184	39.94	4.13	Yes	Yes	2	4	2
15	R:R:M202	R:R:Y114	29.1986	3.59	Yes	Yes	1	5	5
16	L:L:F30	L:L:R32	99.1438	4.28	Yes	Yes	2	0	0
17	L:L:R32	L:L:R51	59.0163	5.33	Yes	Yes	2	0	0
18	L:L:E71	L:L:R32	18.3247	10.47	No	Yes	2	0	0
19	L:L:R32	R:R:P24	19.299	7.21	Yes	Yes	2	0	5
20	L:L:C34	L:L:I63	49.817	3.27	No	Yes	0	0	0
21	L:L:I63	L:L:R51	18.1399	3.76	Yes	Yes	2	0	0
22	L:L:E71	L:L:I63	17.4045	4.1	No	Yes	2	0	0
23	L:L:I63	R:R:P24	17.4279	6.77	Yes	Yes	2	0	5
24	L:L:C34	L:L:C73	29.359	7.28	No	No	0	0	0
25	L:L:C73	R:R:S22	26.5191	3.44	No	No	0	0	3
26	L:L:F37	L:L:L75	14.789	4.87	No	No	0	0	0
27	L:L:C34	L:L:L75	17.6361	3.17	No	No	0	0	0
28	L:L:C38	R:R:C21	17.6722	7.28	No	No	0	0	3
29	R:R:C21	R:R:S22	20.623	5.16	No	No	0	3	3
30	L:L:C38	R:R:I20	14.7196	6.55	No	Yes	0	0	3
31	L:L:F64	L:L:W80	14.9639	4.01	No	Yes	3	0	0
32	L:L:F64	L:L:L62	15.9499	3.65	No	Yes	3	0	0
33	L:L:L62	L:L:Y50	34.7072	9.38	Yes	No	3	0	0
34	L:L:H90	L:L:Y50	40.6313	8.71	No	No	0	0	0
35	L:L:H90	L:L:R51	41.5857	3.39	No	Yes	0	0	0
36	L:L:V81	L:L:W80	15.0098	8.58	Yes	Yes	3	0	0
37	L:L:L62	L:L:V81	16.9818	4.47	Yes	Yes	3	0	0
38	L:L:H84	L:L:W80	22.0578	8.46	Yes	Yes	0	0	0
39	L:L:A46	L:L:L48	10.0528	3.15	No	No	0	0	0
40	L:L:L48	L:L:L88	12.0582	8.3	No	No	0	0	0
41	L:L:H84	L:L:L88	16.0634	2.57	Yes	No	0	0	0
42	R:R:K195	R:R:Y184	10.2159	4.78	Yes	Yes	2	5	2
43	R:R:F84	R:R:H292	45.0664	6.79	Yes	Yes	1	6	9
44	R:R:D81	R:R:H292	40.9972	5.04	Yes	Yes	1	9	9
45	R:R:D81	R:R:N53	14.8656	10.77	Yes	No	0	9	9
46	R:R:C293	R:R:F84	36.7513	5.59	No	Yes	1	8	6
47	R:R:C293	R:R:D81	36.4241	4.67	No	Yes	1	8	9
48	R:R:N53	R:R:P297	14.1807	6.52	No	No	0	9	9
49	R:R:P297	R:R:V56	13.2478	3.53	No	No	0	9	9
50	R:R:A78	R:R:V56	12.3132	3.39	No	No	0	9	9
51	R:R:A78	R:R:I57	11.3768	3.25	No	Yes	0	9	7
52	R:R:D81	R:R:N296	63.949	6.73	Yes	No	1	9	9
53	R:R:N296	R:R:Y300	63.21	6.98	No	Yes	1	9	9
54	R:R:M127	R:R:Y300	40.168	3.59	No	Yes	0	9	9
55	R:R:M127	R:R:Y73	39.3352	4.79	No	Yes	0	9	7
56	R:R:D130	R:R:Y73	24.5102	9.2	Yes	Yes	7	8	7
57	R:R:D130	R:R:T70	17.0909	4.34	Yes	No	0	8	8
58	R:R:S68	R:R:T70	16.1544	6.4	No	No	0	7	8
59	R:R:D71	R:R:S68	15.2144	4.42	No	No	0	8	7
60	R:R:D71	R:R:K64	13.3992	4.15	No	No	0	8	5
61	R:R:H310	R:R:K64	12.4538	15.72	No	No	0	4	5
62	R:R:C63	R:R:H310	11.5066	5.9	Yes	No	0	5	4
63	R:R:F117	R:R:M202	24.0081	8.71	Yes	Yes	1	8	5
64	R:R:F117	R:R:M121	11.8608	3.73	Yes	Yes	1	8	7
65	R:R:F211	R:R:W251	12.5286	7.02	Yes	Yes	1	7	9
66	R:R:F211	R:R:L248	20.1164	6.09	Yes	No	0	7	6
67	R:R:L248	R:R:M215	18.3427	4.24	No	No	0	6	4
68	R:R:F214	R:R:M215	17.1603	3.73	Yes	No	0	8	4
69	R:R:R131	R:R:Y300	14.1257	6.17	No	Yes	0	9	9
70	R:R:R131	R:R:Y218	13.3109	12.35	No	Yes	0	9	9
71	R:R:V240	R:R:Y218	16.3671	5.05	No	Yes	0	7	9
72	R:R:L222	R:R:V240	14.8882	4.47	No	No	0	5	7
73	R:R:I237	R:R:L222	11.9248	4.28	No	No	0	7	5
74	R:R:I299	R:R:Y300	10.5476	7.25	No	Yes	1	8	9
75	L:L:F30	R:R:Q182	100	4.68	Yes	Yes	2	0	4
76	R:R:F117	R:R:W251	15.1991	6.01	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K24	R:R:E28	6.75	0	No	No	0	2	0	1
L:L:K24	R:R:Y94	7.17	0	No	No	0	5	0	1
L:L:S25	R:R:Q91	8.66	0	No	No	0	6	0	1
L:L:S25	R:R:E286	8.62	0	No	No	0	5	0	1
L:L:M26	R:R:Y113	4.79	0	No	No	0	6	0	1
L:L:M26	R:R:C183	4.86	0	No	No	0	9	0	1
L:L:Q27	R:R:Y114	5.64	1	No	Yes	0	5	0	1
L:L:Q27	R:R:M202	4.08	1	No	Yes	0	5	0	1
L:L:Q27	R:R:L258	5.32	1	No	No	0	5	0	1
L:L:V28	R:R:T282	4.76	0	No	No	0	4	0	1
L:L:P29	R:R:Q182	4.74	2	Yes	Yes	0	4	0	1
L:L:P29	R:R:Y184	16.69	2	Yes	Yes	0	2	0	1
L:L:F30	R:R:E28	9.33	2	Yes	No	0	2	0	1
L:L:F30	R:R:V180	3.93	2	Yes	No	0	3	0	1
L:L:F30	R:R:Q182	4.68	2	Yes	Yes	0	4	0	1
L:L:R32	R:R:P24	7.21	2	Yes	Yes	0	5	0	1
L:L:R32	R:R:D26	13.1	2	Yes	No	0	3	0	1
L:L:R32	R:R:D178	11.91	2	Yes	No	0	2	0	1
L:L:F35	R:R:C25	5.59	9	Yes	No	0	9	0	1
L:L:F35	R:R:C272	6.98	9	Yes	No	0	8	0	1
L:L:F35	R:R:S275	5.28	9	Yes	No	0	1	0	1
L:L:S36	R:R:S22	6.52	0	No	No	0	3	0	1
L:L:C38	R:R:I20	6.55	0	No	Yes	0	3	0	1
L:L:C38	R:R:C21	7.28	0	No	No	0	3	0	1
L:L:Q40	R:R:I20	6.86	0	No	Yes	0	3	0	1
L:L:R51	R:R:D178	10.72	2	Yes	No	0	2	0	1
L:L:S55	R:R:T191	7.99	0	No	No	0	3	0	1
L:L:I56	R:R:Y184	6.04	2	Yes	Yes	0	2	0	1
L:L:I56	R:R:T191	6.08	2	Yes	No	0	3	0	1
L:L:S58	R:R:L192	7.51	0	No	No	0	1	0	1
L:L:S58	R:R:H267	4.18	0	No	No	0	1	0	1
L:L:N59	R:R:D270	4.04	0	No	No	0	1	0	1
L:L:I63	R:R:P24	6.77	2	Yes	Yes	0	5	0	1
L:L:E71	R:R:P24	9.43	2	No	Yes	0	5	0	1
L:L:A72	R:R:I20	4.87	0	No	Yes	0	3	0	1
R:R:C21	R:R:S22	5.16	0	No	No	3	3	1	1
R:R:P24	R:R:S23	3.56	2	Yes	No	5	5	1	2
R:R:C25	R:R:C272	7.28	9	No	No	9	8	1	1
R:R:Q91	R:R:Y42	12.4	0	No	Yes	6	7	1	2
R:R:F290	R:R:Y42	5.16	1	Yes	Yes	7	7	2	2
R:R:F84	R:R:Y113	9.28	1	Yes	No	6	6	2	1
R:R:F290	R:R:F84	7.5	1	Yes	Yes	7	6	2	2
R:R:W99	R:R:Y94	10.61	4	Yes	No	9	5	2	1
R:R:Q182	R:R:Y94	4.51	2	Yes	No	4	5	1	1
R:R:C106	R:R:W99	3.92	4	No	Yes	9	9	2	2
R:R:C183	R:R:W99	15.67	4	No	Yes	9	9	1	2
R:R:C106	R:R:C183	7.28	4	No	No	9	9	2	1
R:R:Y113	R:R:Y114	12.91	0	No	Yes	6	5	1	1
R:R:T165	R:R:Y114	3.75	0	No	Yes	7	5	2	1
R:R:L168	R:R:Y114	12.89	0	No	Yes	4	5	2	1
R:R:Y114	R:R:Y172	10.92	1	Yes	No	5	4	1	2
R:R:M202	R:R:Y114	3.59	1	Yes	Yes	5	5	1	1
R:R:F117	R:R:Y118	10.32	1	Yes	Yes	8	7	2	2
R:R:F117	R:R:M202	8.71	1	Yes	Yes	8	5	2	1
R:R:M202	R:R:Y118	3.59	1	Yes	Yes	5	7	1	2
R:R:Y172	R:R:Y184	4.96	0	No	Yes	4	2	2	1
R:R:E177	R:R:Q182	5.1	2	No	Yes	1	4	2	1
R:R:E177	R:R:F186	7	2	No	Yes	1	4	2	2
R:R:Q182	R:R:V180	5.73	2	Yes	No	4	3	1	1
R:R:F186	R:R:Q182	7.03	2	Yes	Yes	4	4	2	1
R:R:S185	R:R:Y184	8.9	0	No	Yes	4	2	2	1
R:R:F186	R:R:Y184	4.13	2	Yes	Yes	4	2	2	1
R:R:K195	R:R:Y184	4.78	2	Yes	Yes	5	2	2	1
R:R:F186	R:R:T191	6.49	2	Yes	No	4	3	2	1
R:R:K195	R:R:S265	9.18	2	Yes	No	5	3	2	1
R:R:I196	R:R:S265	4.64	0	No	No	3	3	2	1
R:R:F254	R:R:L258	14.61	0	No	No	7	5	2	1
R:R:H264	R:R:S275	6.97	0	No	No	2	1	2	1
R:R:E286	R:R:F290	12.83	0	No	Yes	5	7	1	2
L:L:C73	R:R:S22	3.44	0	No	No	0	3	0	1
L:L:S58	R:R:S265	3.26	0	No	No	0	3	0	1
L:L:V28	R:R:T279	3.17	0	No	No	0	4	0	1
L:L:F35	R:R:G271	3.01	9	Yes	No	0	3	0	1
L:L:K70	R:R:I20	2.91	0	No	Yes	0	3	0	1
L:L:S25	R:R:H283	2.79	0	No	No	0	4	0	1
L:L:S93	R:R:G179	1.86	0	No	No	0	4	0	1
R:R:G179	R:R:S176	1.86	0	No	No	4	3	1	2
L:L:S31	R:R:A27	1.71	0	No	No	0	3	0	1
R:R:C25	R:R:Q276	1.53	9	No	No	9	3	1	2
L:L:L66	R:R:I20	1.43	0	No	Yes	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U1U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.56
Number of Linked Nodes	352
Number of Links	401
Number of Hubs	52
Number of Links mediated by Hubs	201
Number of Communities	10
Number of Nodes involved in Communities	76
Number of Links involved in Communities	103

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	182721
Length Of Smallest Path	3
Average Path Length	18.4609
Length of Longest Path	38
Minimum Path Strength	1.38
Average Path Strength	6.35613
Maximum Path Strength	17.91
Minimum Path Correlation	0.7
Average Path Correlation	0.937727
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	44.1161
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.9138
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • protein binding • binding • chemokine binding • cytokine binding • molecular function activator activity • signaling receptor binding • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CCR chemokine receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • cellular response to chemical stimulus • cell migration • cellular process
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • cellular response to chemical stimulus • cell migration • cellular process • cell motility • immune response • immune system process • cell adhesion • regulation of biological process • regulation of cellular process • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • positive regulation of cellular process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to external biotic stimulus • viral process • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • interleukin-17 production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • regulation of interleukin-17 production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • metabolic process • regulation of macromolecule biosynthetic process • positive regulation of interleukin-17 production • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • eosinophil chemotaxis • granulocyte migration • eosinophil migration • granulocyte chemotaxis • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular region • extracellular space • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Interleukin 8-like chemokines • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51685
Sequence	>8U1U_nogp_Chain_R D I C S S P C D A E L I Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C K K L R S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D Q W V F G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H A V Y A L K V R T I R M G T T L C L A V W L T A I M A T I P L L V F Y Q V A S E D G V L Q C Y S F Y N Q Q T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C Q N H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I L D G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K F K K H L S E I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XML	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	2.58	2025-01-01	To be published
	8XML (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		2.58	2025-01-01	To be published
	8KFZ	A	Protein	Chemokine	CCR8	Homo sapiens	-	-	Gi1/β1/γ2	3.3	2024-02-07	10.1126/sciadv.adj7500
	8KFZ (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	-	-		3.3	2024-02-07	10.1126/sciadv.adj7500
	8KFY	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-	Gi1/β1/γ2	3.06	2024-02-07	10.1126/sciadv.adj7500
	8KFY (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	ZK-756326	-		3.06	2024-02-07	10.1126/sciadv.adj7500
	8KFX	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-	Gi1/β1/γ2	2.96	2024-02-07	10.1126/sciadv.adj7500
	8KFX (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	LMD-009	-		2.96	2024-02-07	10.1126/sciadv.adj7500
	8TLM	A	Protein	Chemokine	CCR8	Homo sapiens	Anti-murine CCR8 antibody	-	-	3.9	2023-12-20	10.1038/s41467-023-43601-8
	8U1U	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-	Gi1/β1/γ2	3.1	2023-12-20	10.1038/s41467-023-43601-8
	8U1U (No Gprot)	A	Protein	Chemokine	CCR8	Homo sapiens	CCL1	-		3.1	2023-12-20	10.1038/s41467-023-43601-8

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