Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:D20 5.205426
2A:A:V34 5.21254155
3A:A:L37 5.592509
4A:A:K46 8.45409
5A:A:M53 4.2408
6A:A:L194 5.425154
7A:A:F196 8.53754157
8A:A:F199 8.942515
9A:A:Q204 7.5575419
10A:A:S206 6.035418
11A:A:R208 6.568519
12A:A:K210 5.25519
13A:A:W211 7.46667619
14A:A:I212 4.435418
15A:A:H213 7.5225418
16A:A:F215 6.63519
17A:A:I221 4.83408
18A:A:Y230 6.365648
19A:A:L234 7.29408
20A:A:F250 7.985699
21A:A:I253 5.2975418
22A:A:C254 4.918595
23A:A:W258 7.98515
24A:A:F267 4.62754169
25A:A:N269 4.5375409
26A:A:K270 5.355409
27A:A:F274 6.83549
28A:A:K277 6.448549
29A:A:C286 4.628546
30A:A:Y287 6.976547
31A:A:Y290 7.696547
32A:A:Y296 5.465404
33A:A:Y302 9.106546
34A:A:F307 6.805498
35A:A:N311 6.745498
36A:A:Y320 6.2945107
37A:A:H322 8.745169
38A:A:T324 6.85254169
39A:A:N331 10.15254168
40A:A:F336 10.9554158
41A:A:D341 5.944108
42A:A:F354 7.0825105
43B:B:T34 2.98254115
44B:B:I37 3.9385112
45B:B:V40 4.3454113
46B:B:M45 7.2675474
47B:B:L51 7.715429
48B:B:H54 9.284529
49B:B:Y59 11.1975418
50B:B:M61 5.23426
51B:B:W63 5.71627
52B:B:L70 3.646525
53B:B:V71 4.732588
54B:B:D76 6.628529
55B:B:K78 5.715408
56B:B:L79 5.4275487
57B:B:I80 7.024528
58B:B:I81 4.75587
59B:B:W82 9.86429729
60B:B:N88 4.8025407
61B:B:K89 7.82167629
62B:B:I93 6.72487
63B:B:L95 4.898588
64B:B:W99 8.53143719
65B:B:Y105 4.82375886
66B:B:C114 3.8225488
67B:B:L117 4.735419
68B:B:I120 4.2825406
69B:B:I123 6.07754126
70B:B:Y124 5.18586
71B:B:L126 3.912585
72B:B:E130 4.65754123
73B:B:V133 6.11484
74B:B:H142 7.505619
75B:B:Y145 5.09714718
76B:B:F151 5.512509
77B:B:L152 5.298503
78B:B:T159 6.1675419
79B:B:S161 6.655419
80B:B:D163 8.4275419
81B:B:C166 4.235468
82B:B:W169 9.845618
83B:B:F180 7.876567
84B:B:H183 8.806569
85B:B:D186 5.425419
86B:B:V187 4.47569
87B:B:L190 5.0475465
88B:B:F199 5.77669
89B:B:V200 10.575456
90B:B:S201 4.82469
91B:B:D205 7.436569
92B:B:K209 11.8625466
93B:B:L210 5.895455
94B:B:W211 9.674568
95B:B:D212 7.0475409
96B:B:Q220 6.995457
97B:B:F222 10.005458
98B:B:H225 11.7167659
99B:B:D228 6.542519
100B:B:I229 4.9425457
101B:B:I232 5.855458
102B:B:F234 7.4675455
103B:B:F235 6.8465216
104B:B:F241 9.465656
105B:B:D247 9.6325459
106B:B:T249 7.475456
107B:B:R251 11.045658
108B:B:Q259 3.825406
109B:B:Y264 6.5475405
110B:B:I269 3.43254134
111B:B:F278 6.39754217
112B:B:R283 7.1325119
113B:B:Y289 7.014297137
114B:B:D290 9.32406
115B:B:D291 6.39754138
116B:B:N295 8.49254136
117B:B:V296 3.968575
118B:B:W297 4.98254138
119B:B:D298 7.784119
120B:B:K301 3.6985115
121B:B:V307 4.364133
122B:B:H311 9.185679
123B:B:V315 3.955477
124B:B:T321 7.395427
125B:B:T329 5.366578
126B:B:W332 12.29719
127B:B:L336 6.144527
128B:B:K337 9.81476
129B:B:W339 8.256579
130R:R:Y42 7.196537
131R:R:S49 5.31438
132R:R:N53 5.135439
133R:R:V56 3.7865229
134R:R:K64 7.371676185
135R:R:T70 4.8465208
136R:R:Y73 7.25287
137R:R:L75 5.3025406
138R:R:N76 5.834299
139R:R:D81 5.725439
140R:R:F84 7.932536
141R:R:V85 3.304536
142R:R:F88 7.55437
143R:R:W99 7.533336309
144R:R:C106 4.98754309
145R:R:Y113 7.9675436
146R:R:Y114 8.9025145
147R:R:F117 8.905408
148R:R:Y118 6.168336147
149R:R:F123 6.7754298
150R:R:D130 7.3175408
151R:R:Y132 9.065198
152R:R:V136 8.80754197
153R:R:R145 6.5185257
154R:R:T165 5.12254147
155R:R:L168 8.8354144
156R:R:Y172 8.158504
157R:R:Q182 6.3654314
158R:R:Y184 4.77254312
159R:R:Y187 9.96505
160R:R:K195 7.6475405
161R:R:T198 5.02406
162R:R:N199 4.2645145
163R:R:M202 4.2554145
164R:R:N203 4.554326
165R:R:F214 6.656178
166R:R:C217 4.1425407
167R:R:Y218 7.075717179
168R:R:N230 7.99754104
169R:R:F250 6.054538
170R:R:W251 7.35167639
171R:R:N255 7.0675408
172R:R:F259 6.1654326
173R:R:H264 4.7825332
174R:R:F290 5.68143737
175R:R:H292 6.786539
176R:R:C293 4.6275438
177R:R:Y300 7.8156179
178R:R:F302 5.4365226
179R:R:F307 6.195228
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K89 14.20614.36YesYes289
2B:B:I80 B:B:K78 36.73022.91YesYes088
3B:B:K78 B:B:P94 43.14363.35YesNo085
4B:B:I93 B:B:P94 43.77953.39YesNo075
5B:B:I93 B:B:V133 22.144510.75YesYes874
6B:B:I93 B:B:L79 22.24344.28YesYes877
7B:B:L79 B:B:V71 28.50272.98YesYes878
8B:B:V71 B:B:Y105 29.37616.31YesYes886
9B:B:H62 B:B:Y105 57.04964.36NoYes066
10B:B:H62 B:B:R150 57.344220.31NoNo066
11B:B:C148 B:B:R150 57.64144.18NoNo066
12B:B:C148 B:B:L190 57.93836.35NoYes065
13B:B:L190 B:B:S160 66.32824.5YesNo056
14B:B:S147 B:B:S160 75.09654.89NoNo096
15B:B:M188 B:B:S147 75.38093.07NoNo089
16B:B:M188 B:B:Y145 75.40733.59NoYes188
17A:A:Q204 B:B:Y145 71.35515.64YesYes198
18A:A:Q204 A:A:W211 24.157412.05YesYes199
19A:A:F215 A:A:W211 43.55263.01YesYes199
20A:A:F199 A:A:F215 60.50934.29YesYes159
21A:A:F199 A:A:K35 93.25878.69YesNo059
22A:A:K35 A:A:T219 1003NoNo097
23A:A:T219 A:A:V34 99.85217.93NoYes075
24A:A:L194 A:A:V34 79.00474.47YesYes1545
25A:A:L194 R:R:L142 80.0081.38YesNo044
26R:R:K143 R:R:L142 79.83191.41NoNo054
27R:R:K143 R:R:Y140 79.65634.78NoNo054
28R:R:V144 R:R:Y140 79.48238.83NoNo044
29R:R:L133 R:R:V144 79.31141.49NoNo054
30R:R:A141 R:R:L133 79.14121.58NoNo065
31R:R:A141 R:R:R145 78.97151.38NoYes067
32R:R:D130 R:R:R145 70.464416.68YesYes087
33R:R:D130 R:R:Y73 62.73716.9YesYes087
34B:B:L126 B:B:V133 23.42.98YesYes854
35B:B:L126 B:B:Y105 24.90753.52YesYes856
36A:A:S206 B:B:Y145 24.11685.09YesYes188
37A:A:S206 A:A:W211 29.41347.41YesYes189
38A:A:Q204 B:B:L117 47.50675.32YesYes199
39A:A:F215 B:B:L117 19.42783.65YesYes199
40B:B:L117 B:B:W99 28.16985.69YesYes199
41A:A:F199 B:B:W99 33.37216.04YesYes159
42A:A:F196 A:A:V34 20.54055.24YesYes1575
43A:A:F189 A:A:F196 23.101613.93NoYes097
44A:A:F189 A:A:M53 22.88174.98NoYes098
45A:A:M198 A:A:M53 15.10532.89NoYes078
46A:A:L38 A:A:M198 14.40135.65NoNo087
47A:A:I222 A:A:L38 12.82614.28NoNo078
48B:B:Q75 B:B:W99 29.16135.48NoYes199
49B:B:Q75 B:B:Y59 28.349210.15NoYes198
50B:B:W332 B:B:Y59 27.682215.43YesYes198
51A:A:I222 A:A:I265 12.38982.94NoNo078
52A:A:F223 A:A:F250 11.962111.79NoYes099
53A:A:F250 A:A:F307 15.361110.72YesYes998
54B:B:R314 B:B:W332 26.393527.99NoYes189
55A:A:A338 A:A:I265 12.39484.87NoNo068
56A:A:A338 A:A:Y320 12.42628.01NoYes067
57A:A:K345 R:R:N230 12.254412.59NoYes1054
58R:R:M127 R:R:Y73 60.42075.99NoYes097
59R:R:M127 R:R:Y300 60.22649.58NoYes099
60R:R:D71 R:R:T70 14.71932.89NoYes2088
61R:R:D71 R:R:L60 14.294.07NoNo087
62R:R:L60 R:R:V56 10.63132.98NoYes079
63B:B:D290 B:B:R314 26.452620.25YesNo068
64B:B:C271 B:B:D290 26.319.34NoYes056
65B:B:C271 B:B:Y289 24.98814.03NoYes1357
66B:B:W297 B:B:Y289 15.9395.79YesYes1387
67B:B:W297 B:B:Y264 15.92186.75YesYes085
68B:B:M262 B:B:Y264 16.28958.38NoYes045
69B:B:L30 B:B:M262 16.05314.24NoNo054
70B:B:L30 B:B:T34 15.9772.95NoYes055
71B:B:R283 B:B:V40 13.15.23YesYes1193
72B:B:L284 B:B:V40 12.63774.47NoYes053
73B:B:L284 B:B:V296 12.11054.47NoYes055
74B:B:L70 B:B:W82 14.22923.42YesYes259
75B:B:G162 B:B:Y145 21.00347.24NoYes198
76B:B:G162 B:B:S161 25.46883.71NoYes199
77B:B:H142 B:B:S161 22.599812.55YesYes199
78B:B:H142 B:B:W169 19.35158.46YesYes198
79B:B:I157 B:B:W169 17.75033.52NoYes078
80R:R:I124 R:R:Y300 52.25597.25NoYes089
81R:R:I124 R:R:W251 51.93193.52NoYes089
82R:R:H292 R:R:W251 13.715212.7YesYes399
83R:R:M121 R:R:W251 35.6378.14NoYes079
84R:R:F117 R:R:M121 35.405914.93YesNo087
85R:R:F117 R:R:Y118 16.53739.28YesYes087
86R:R:Y114 R:R:Y172 16.77428.94YesYes054
87R:R:C106 R:R:Y172 14.86784.03YesYes094
88R:R:C106 R:R:W99 10.26825.22YesYes3099
89R:R:F117 R:R:M202 18.86274.98YesYes085
90B:B:I80 B:B:W82 19.976611.74YesYes289
91B:B:L70 B:B:W63 11.66473.42YesYes257
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8KFZ
Class A
SubFamily Protein
Type Chemokine
SubType CCR8
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.3
Date 2024-02-07
D.O.I. 10.1126/sciadv.adj7500
Net Summary
Imin 2.89
Number of Linked Nodes 807
Number of Links 1007
Number of Hubs 179
Number of Links mediated by Hubs 641
Number of Communities 33
Number of Nodes involved in Communities 270
Number of Links involved in Communities 389
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 1295310
Length Of Smallest Path 3
Average Path Length 31.0741
Length of Longest Path 58
Minimum Path Strength 1.22
Average Path Strength 6.33521
Maximum Path Strength 24.12
Minimum Path Correlation 0.71
Average Path Correlation 0.983792
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 43.5574
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1225
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • coreceptor activity   • signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine binding   • protein binding   • binding   • chemokine binding   • cytokine binding   • chemotaxis   • response to stimulus   • taxis   • response to chemical   • response to external stimulus   • locomotion   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cell chemotaxis   • cellular response to stimulus   • cellular response to chemical stimulus   • cell migration   • cellular process
Gene OntologyBiological Process• chemotaxis   • response to stimulus   • taxis   • response to chemical   • response to external stimulus   • locomotion   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • cell chemotaxis   • cellular response to stimulus   • cellular response to chemical stimulus   • cell migration   • cellular process   • cell motility   • immune response   • immune system process   • cell adhesion   • regulation of biological process   • regulation of cellular process   • signaling   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8KFZ_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKTG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLAED EEMNRMHES MKLFDSICN NKWFTDTSI 
ILFLNKKDL FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED 
LNKRKDTKE IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8KFZ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP51685
Sequence
>8KFZ_Chain_R
IQTNGKLLL AVFYCLLFV FSLLGNSLV ILVLVVCKK LRSITDVYL 
LNLALSDLL FVFSFPFQT YYLLDQWVF GTVMCKVVS GFYYIGFYS 
SMFFITLMS VDRYLAVVH AVYALKVRT IRMGTTLCL AVWLTAIMA 
TIPLLVFYQ VASEDGVLQ CYSFYNQQT LKWKIFTNF KMNILGLLI 
PFTIFMFCY IKILHQLKR CQNHNKTKA IRLVLIVVI ASLLFWVPF 
NVVLFLTSL HSMHILDGC SISQQLTYA THVTEIISF THCCVNPVI 
YAFVGEKFK KHLSEIFQK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XMLAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ22.582025-01-01To be published
8XML (No Gprot) AProteinChemokineCCR8Homo sapiens--2.582025-01-01To be published
8KFZAProteinChemokineCCR8Homo sapiens--Gi1/β1/γ23.32024-02-0710.1126/sciadv.adj7500
8KFZ (No Gprot) AProteinChemokineCCR8Homo sapiens--3.32024-02-0710.1126/sciadv.adj7500
8KFYAProteinChemokineCCR8Homo sapiensZK-756326-Gi1/β1/γ23.062024-02-0710.1126/sciadv.adj7500
8KFY (No Gprot) AProteinChemokineCCR8Homo sapiensZK-756326-3.062024-02-0710.1126/sciadv.adj7500
8KFXAProteinChemokineCCR8Homo sapiensLMD-009-Gi1/β1/γ22.962024-02-0710.1126/sciadv.adj7500
8KFX (No Gprot) AProteinChemokineCCR8Homo sapiensLMD-009-2.962024-02-0710.1126/sciadv.adj7500
8TLMAProteinChemokineCCR8Homo sapiensAnti-murine CCR8 antibody--3.92023-12-2010.1038/s41467-023-43601-8
8U1UAProteinChemokineCCR8Homo sapiensCCL1-Gi1/β1/γ23.12023-12-2010.1038/s41467-023-43601-8
8U1U (No Gprot) AProteinChemokineCCR8Homo sapiensCCL1-3.12023-12-2010.1038/s41467-023-43601-8




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