psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I2	R:R:P3	6.77	No	No	0	6	6
2	R:R:P3	R:R:Q5	9.47	No	No	0	6	6
3	R:R:I4	R:R:Q5	4.12	No	No	0	4	6
4	R:R:F10	R:R:L6	7.31	Yes	No	0	5	5
5	R:R:F10	R:R:F9	10.72	Yes	No	3	5	5
6	R:R:F9	R:R:I13	6.28	No	Yes	3	5	7
7	R:R:F10	R:R:I13	3.77	Yes	Yes	3	5	7
8	R:R:F10	R:R:V260	17.04	Yes	No	0	5	4
9	R:R:M11	R:R:W259	17.45	No	Yes	0	4	3
10	R:R:E17	R:R:I13	4.1	Yes	Yes	0	8	7
11	R:R:S18	R:R:Y14	5.09	Yes	Yes	0	6	4
12	R:R:S63	R:R:Y14	3.82	Yes	Yes	1	5	4
13	R:R:N67	R:R:Y14	4.65	Yes	Yes	1	3	4
14	R:R:E262	R:R:Y14	6.73	Yes	Yes	1	3	4
15	R:R:Y14	R:R:Y266	9.93	Yes	Yes	1	4	4
16	R:R:Q60	R:R:S18	4.33	Yes	Yes	0	7	6
17	R:R:M64	R:R:S18	7.67	No	Yes	0	3	6
18	R:R:Q24	R:R:T20	4.25	No	No	0	7	5
19	R:R:L270	R:R:T20	4.42	Yes	No	0	7	5
20	R:R:I21	R:R:Q60	12.35	No	Yes	0	8	7
21	R:R:I21	R:R:L270	5.71	No	Yes	0	8	7
22	R:R:F57	R:R:I22	3.77	Yes	No	4	6	7
23	R:R:I22	R:R:Q60	5.49	No	Yes	0	7	7
24	R:R:I22	R:R:W61	10.57	No	No	4	7	3
25	R:R:G53	R:R:S25	3.71	No	No	0	8	9
26	R:R:F57	R:R:S25	3.96	Yes	No	0	6	9
27	R:R:I28	R:R:M277	5.83	No	No	0	9	9
28	R:R:L283	R:R:V31	4.47	Yes	No	0	9	8
29	R:R:D46	R:R:L32	6.79	Yes	No	5	9	8
30	R:R:I50	R:R:L32	5.71	No	No	0	6	8
31	R:R:L32	R:R:T282	5.9	No	No	5	8	8
32	R:R:Q38	R:R:R34	4.67	No	No	0	6	4
33	R:R:E35	R:R:V39	4.28	No	No	0	7	5
34	R:R:E35	R:R:T282	4.23	No	No	0	7	8
35	R:R:E35	R:R:R285	5.82	No	No	0	7	6
36	R:R:L42	R:R:W36	13.67	No	No	0	7	6
37	R:R:M47	R:R:W36	5.82	No	No	0	5	6
38	R:R:D46	R:R:L42	12.21	Yes	No	0	9	7
39	R:R:D46	R:R:M43	12.48	Yes	No	0	9	7
40	R:R:F102	R:R:P44	14.45	Yes	No	2	8	6
41	R:R:F126	R:R:P44	14.45	Yes	No	2	7	6
42	R:R:F102	R:R:V45	6.55	Yes	No	0	8	5
43	R:R:P281	R:R:V45	3.53	No	No	0	7	5
44	R:R:D46	R:R:T282	11.56	Yes	No	5	9	8
45	R:R:F126	R:R:M47	3.73	Yes	No	0	7	5
46	R:R:M47	R:R:P127	8.39	No	No	0	5	7
47	R:R:I48	R:R:L98	5.71	Yes	Yes	2	9	6
48	R:R:I48	R:R:L99	7.14	Yes	No	0	9	9
49	R:R:F126	R:R:I48	3.77	Yes	Yes	2	7	9
50	R:R:I48	R:R:L130	4.28	Yes	No	0	9	8
51	R:R:L95	R:R:S51	10.51	No	No	0	7	7
52	R:R:L130	R:R:S51	4.5	No	No	0	8	7
53	R:R:L52	R:R:R56	8.5	No	Yes	1	9	9
54	R:R:L52	R:R:T92	4.42	No	No	1	9	8
55	R:R:L52	R:R:L95	5.54	No	No	0	9	7
56	R:R:L91	R:R:S55	9.01	Yes	No	0	6	8
57	R:R:R56	R:R:T92	6.47	Yes	No	1	9	8
58	R:R:I269	R:R:R56	10.02	No	Yes	0	8	9
59	R:R:H272	R:R:R56	14.67	Yes	Yes	1	9	9
60	R:R:C58	R:R:F57	4.19	No	Yes	0	2	6
61	R:R:F57	R:R:W61	9.02	Yes	No	4	6	3
62	R:R:C58	R:R:F88	8.38	No	No	0	2	4
63	R:R:L59	R:R:W85	12.53	No	Yes	0	5	5
64	R:R:F88	R:R:L59	3.65	No	No	0	4	5
65	R:R:Q60	R:R:Y266	11.27	Yes	Yes	0	7	4
66	R:R:M64	R:R:W61	4.65	No	No	0	3	3
67	R:R:N67	R:R:S63	4.47	Yes	Yes	1	3	5
68	R:R:S63	R:R:W85	4.94	Yes	Yes	1	5	5
69	R:R:S63	R:R:Y266	11.45	Yes	Yes	1	5	4
70	L:L:?1	R:R:S63	5.93	Yes	Yes	1	0	5
71	R:R:N66	R:R:N80	4.09	Yes	No	0	5	3
72	R:R:N66	R:R:T82	4.39	Yes	No	0	5	1
73	L:L:?1	R:R:N66	7.23	Yes	Yes	0	0	5
74	R:R:L258	R:R:N67	6.87	Yes	Yes	1	2	3
75	R:R:E262	R:R:N67	17.09	Yes	Yes	1	3	3
76	L:L:?1	R:R:N67	7.23	Yes	Yes	1	0	3
77	R:R:F68	R:R:W259	4.01	No	Yes	0	3	3
78	R:R:C69	R:R:C79	7.28	No	No	0	3	3
79	R:R:L258	R:R:Y71	7.03	Yes	Yes	1	2	2
80	R:R:W259	R:R:Y71	24.12	Yes	Yes	1	3	2
81	R:R:L81	R:R:T84	8.84	No	No	0	2	2
82	R:R:I83	R:R:S144	4.64	No	No	0	4	3
83	R:R:N89	R:R:W85	10.17	Yes	Yes	1	8	5
84	R:R:I243	R:R:W85	4.7	No	Yes	1	3	5
85	R:R:W85	R:R:Y266	7.72	Yes	Yes	1	5	4
86	L:L:?1	R:R:W85	37.46	Yes	Yes	1	0	5
87	R:R:E86	R:R:H181	17.23	No	No	0	4	2
88	L:L:?1	R:R:E86	11.33	Yes	No	0	0	4
89	R:R:F87	R:R:F88	8.57	Yes	No	0	7	4
90	R:R:F87	R:R:T137	7.78	Yes	Yes	0	7	8
91	R:R:C138	R:R:F87	4.19	No	Yes	0	3	7
92	R:R:F87	R:R:I141	12.56	Yes	No	0	7	5
93	R:R:F93	R:R:N89	7.25	Yes	Yes	1	6	8
94	R:R:L185	R:R:N89	6.87	No	Yes	1	5	8
95	R:R:N89	R:R:Y239	6.98	Yes	Yes	1	8	7
96	R:R:I90	R:R:T137	6.08	No	Yes	0	6	8
97	R:R:L91	R:R:L95	4.15	Yes	No	0	6	7
98	R:R:L91	R:R:T137	5.9	Yes	Yes	0	6	8
99	R:R:F93	R:R:L185	4.87	Yes	No	1	6	5
100	R:R:F93	R:R:P188	4.33	Yes	Yes	0	6	8
101	R:R:F236	R:R:F93	16.08	Yes	Yes	1	7	6
102	R:R:F93	R:R:Y239	5.16	Yes	Yes	1	6	7
103	R:R:F240	R:R:F93	8.57	Yes	Yes	1	6	6
104	R:R:I136	R:R:W94	10.57	No	No	0	4	9
105	R:R:T137	R:R:W94	6.06	Yes	No	0	8	9
106	R:R:P188	R:R:W94	24.32	Yes	No	0	8	9
107	R:R:F192	R:R:N96	8.46	Yes	No	1	8	7
108	R:R:F236	R:R:N96	19.33	Yes	No	1	7	7
109	R:R:H272	R:R:N96	8.93	Yes	No	1	9	7
110	R:R:P188	R:R:S97	3.56	Yes	No	0	8	8
111	R:R:F126	R:R:L98	7.31	Yes	Yes	2	7	6
112	R:R:I129	R:R:L98	5.71	No	Yes	0	7	6
113	R:R:C133	R:R:L98	4.76	No	Yes	0	8	6
114	R:R:L99	R:R:Y103	12.89	No	No	0	9	9
115	R:R:L276	R:R:L99	4.15	Yes	No	0	9	9
116	R:R:F192	R:R:T100	6.49	Yes	No	1	8	8
117	R:R:T100	R:R:T196	6.28	No	Yes	1	8	7
118	R:R:S195	R:R:V101	4.85	No	No	0	8	7
119	R:R:F102	R:R:Y103	4.13	Yes	No	0	8	9
120	R:R:F102	R:R:K106	9.93	Yes	No	0	8	9
121	R:R:F102	R:R:F126	6.43	Yes	Yes	2	8	7
122	R:R:C104	R:R:F198	4.19	No	No	0	8	7
123	R:R:I105	R:R:I122	4.42	No	No	0	7	8
124	R:R:F110	R:R:F115	4.29	No	No	0	8	9
125	R:R:H112	R:R:H113	15.53	No	No	6	7	5
126	R:R:H112	R:R:I114	6.63	No	No	6	7	4
127	R:R:F115	R:R:H112	11.31	No	No	0	9	7
128	R:R:H113	R:R:I114	7.95	No	No	6	5	4
129	R:R:L116	R:R:W120	10.25	No	No	0	6	4
130	R:R:W117	R:R:W120	5.62	No	No	0	6	4
131	R:R:R121	R:R:W117	14.99	No	No	0	8	6
132	R:R:I122	R:R:L118	4.28	No	No	0	8	8
133	R:R:R121	R:R:R124	5.33	No	No	0	8	5
134	R:R:F126	R:R:I122	3.77	Yes	No	0	7	8
135	R:R:L125	R:R:W128	6.83	No	No	0	6	3
136	R:R:G132	R:R:M135	5.24	No	No	0	5	5
137	R:R:I141	R:R:S144	4.64	No	No	0	5	3
138	R:R:P143	R:R:Y176	4.17	No	No	0	4	3
139	R:R:H181	R:R:S144	8.37	No	No	0	2	3
140	R:R:G147	R:R:I146	3.53	No	No	0	3	3
141	R:R:I146	R:R:Y176	4.84	No	No	0	3	3
142	R:R:N148	R:R:Q151	5.28	No	No	0	3	3
143	R:R:Q153	R:R:Y149	16.91	No	No	0	3	3
144	R:R:F173	R:R:I150	5.02	No	Yes	0	4	2
145	R:R:I152	R:R:L155	4.28	No	No	0	2	3
146	R:R:E171	R:R:F173	5.83	No	No	0	3	4
147	R:R:H174	R:R:Q177	8.65	No	No	0	3	1
148	R:R:H174	R:R:T250	4.11	No	No	0	3	3
149	R:R:H181	R:R:Q177	3.71	No	No	0	2	1
150	R:R:F178	R:R:Q179	7.03	No	No	0	4	4
151	R:R:F178	R:R:I248	5.02	No	No	0	4	4
152	R:R:Q179	R:R:T182	4.25	No	No	0	4	4
153	R:R:I187	R:R:V183	4.61	No	No	0	5	5
154	R:R:F240	R:R:L185	4.87	Yes	No	1	6	5
155	R:R:F240	R:R:V186	6.55	Yes	No	0	6	3
156	R:R:F189	R:R:F236	4.29	No	Yes	0	6	7
157	R:R:F189	R:R:T237	6.49	No	No	0	6	5
158	R:R:F189	R:R:F240	27.86	No	Yes	0	6	6
159	R:R:F192	R:R:T196	7.78	Yes	Yes	1	8	7
160	R:R:F192	R:R:F236	16.08	Yes	Yes	1	8	7
161	R:R:F233	R:R:L193	6.09	No	No	0	7	6
162	R:R:F233	R:R:T196	6.49	No	Yes	0	7	7
163	R:R:L199	R:R:L229	6.92	No	No	0	9	7
164	R:R:L226	R:R:M200	4.24	No	No	0	7	8
165	R:R:K205	R:R:S202	6.12	No	No	0	5	9
166	R:R:L203	R:R:R222	7.29	Yes	Yes	0	9	9
167	R:R:K205	R:R:Q206	4.07	No	No	0	5	5
168	R:R:Q206	R:R:R222	11.68	No	Yes	0	5	9
169	R:R:I207	R:R:M219	4.37	No	Yes	7	8	7
170	R:R:I207	R:R:R222	8.77	No	Yes	7	8	9
171	R:R:F223	R:R:I207	15.07	No	No	0	6	8
172	R:R:H210	R:R:H214	5.97	No	No	0	6	5
173	R:R:H210	R:R:M219	3.94	No	Yes	0	6	7
174	R:R:H214	R:R:N216	6.38	No	No	0	5	8
175	R:R:M219	R:R:R222	4.96	Yes	Yes	7	7	9
176	R:R:K220	R:R:T224	4.5	No	No	0	6	5
177	R:R:R227	R:R:T224	5.17	No	No	0	7	5
178	R:R:H272	R:R:L232	9	Yes	No	1	9	8
179	R:R:L232	R:R:S275	4.5	No	No	0	8	7
180	R:R:L232	R:R:L276	4.15	No	Yes	1	8	9
181	R:R:M271	R:R:V235	6.09	No	No	0	4	7
182	R:R:H272	R:R:V235	4.15	Yes	No	0	9	7
183	R:R:F236	R:R:H272	9.05	Yes	Yes	1	7	9
184	R:R:F268	R:R:S238	17.18	No	No	0	5	6
185	R:R:I243	R:R:Y239	12.09	No	Yes	1	3	7
186	R:R:V265	R:R:Y239	3.79	Yes	Yes	1	4	7
187	R:R:I269	R:R:Y239	8.46	No	Yes	0	8	7
188	R:R:T242	R:R:W261	8.49	No	Yes	0	6	4
189	R:R:T242	R:R:V265	9.52	No	Yes	0	6	4
190	R:R:I243	R:R:V265	4.61	No	Yes	1	3	4
191	R:R:F252	R:R:I245	5.02	No	No	0	2	5
192	R:R:I245	R:R:W261	5.87	No	Yes	0	5	4
193	R:R:T246	R:R:W261	6.06	No	Yes	0	4	4
194	L:L:?1	R:R:T246	6.79	Yes	No	0	0	4
195	L:L:?1	R:R:I247	5.63	Yes	No	0	0	4
196	R:R:F252	R:R:I248	17.58	No	No	0	2	4
197	R:R:L251	R:R:T250	4.42	No	No	0	1	3
198	R:R:D253	R:R:W257	4.47	No	No	0	1	3
199	R:R:L258	R:R:W259	7.97	Yes	Yes	1	2	3
200	R:R:E262	R:R:Y266	5.61	Yes	Yes	1	3	4
201	L:L:?1	R:R:E262	15.69	Yes	Yes	1	0	3
202	R:R:F264	R:R:F268	9.65	No	No	0	4	5
203	R:R:V265	R:R:Y266	6.31	Yes	Yes	1	4	4
204	R:R:I269	R:R:Y266	6.04	No	Yes	0	8	4
205	L:L:?1	R:R:Y266	6.17	Yes	Yes	1	0	4
206	R:R:H272	R:R:L276	5.14	Yes	Yes	1	9	9
207	R:R:L276	R:R:S279	4.5	Yes	No	0	9	7
208	R:R:L283	R:R:M277	5.65	Yes	No	0	9	9
209	R:R:P281	R:R:S280	3.56	No	No	0	7	9
210	R:R:L283	R:R:S280	4.5	Yes	No	0	9	9
211	R:R:L283	R:R:L287	4.15	Yes	No	0	9	6
212	R:R:L74	R:R:Y76	3.52	No	No	0	4	2
213	R:R:E262	R:R:R255	3.49	Yes	No	0	3	5
214	R:R:C215	R:R:S218	3.44	No	No	0	6	8
215	R:R:I142	R:R:P143	3.39	No	No	0	5	4
216	R:R:I187	R:R:P188	3.39	No	Yes	0	5	8
217	R:R:N216	R:R:P217	3.26	No	No	0	8	5
218	R:R:A263	R:R:I13	3.25	No	Yes	0	5	7
219	R:R:A145	R:R:I83	3.25	No	No	0	4	4
220	R:R:A184	R:R:I90	3.25	No	No	0	4	6
221	R:R:C215	R:R:M219	3.24	No	Yes	0	6	7
222	R:R:S18	R:R:V15	3.23	Yes	No	0	6	4
223	R:R:S26	R:R:V23	3.23	No	No	0	8	5
224	R:R:S275	R:R:V231	3.23	No	No	0	7	7
225	R:R:S195	R:R:T100	3.2	No	No	0	8	8
226	R:R:I21	R:R:S273	3.1	No	No	0	8	9
227	R:R:F72	R:R:Y71	3.09	No	Yes	0	3	2
228	R:R:I50	R:R:V29	3.07	No	No	0	6	6
229	R:R:A267	R:R:E17	3.02	No	Yes	0	6	8
230	R:R:M200	R:R:T196	3.01	No	Yes	0	8	7
231	R:R:L49	R:R:S280	3	No	No	0	8	9
232	R:R:L258	R:R:S70	3	Yes	No	0	2	3
233	R:R:L78	R:R:V77	2.98	No	No	0	1	3
234	R:R:L199	R:R:V107	2.98	No	No	0	9	9
235	R:R:L226	R:R:T204	2.95	No	No	0	7	6
236	R:R:I12	R:R:M11	2.92	No	No	0	5	4
237	R:R:I105	R:R:L123	2.85	No	No	0	7	7
238	R:R:I197	R:R:L193	2.85	No	No	0	5	6
239	R:R:I248	R:R:L244	2.85	No	No	0	4	4
240	R:R:I286	R:R:L287	2.85	No	No	0	5	6
241	R:R:L65	R:R:L81	2.77	No	No	0	4	2
242	R:R:L134	R:R:L91	2.77	No	Yes	0	5	6
243	R:R:L203	R:R:L226	2.77	Yes	No	0	9	7
244	R:R:L81	R:R:N66	2.75	No	Yes	0	2	5
245	R:R:C79	R:R:Y76	2.69	No	No	0	3	2
246	R:R:E17	R:R:L16	2.65	Yes	No	0	8	5
247	R:R:E17	R:R:L270	2.65	Yes	Yes	0	8	7
248	R:R:F198	R:R:S202	2.64	No	No	0	7	9
249	R:R:C256	R:R:W257	2.61	No	No	0	1	3
250	R:R:T7	R:R:Y71	2.5	No	Yes	0	4	2
251	R:R:F268	R:R:M271	2.49	No	No	0	5	4
252	R:R:L37	R:R:R40	2.43	No	No	0	5	7
253	R:R:L123	R:R:R119	2.43	No	No	0	7	9
254	R:R:L131	R:R:W128	2.28	No	No	0	5	3
255	R:R:D253	R:R:W261	2.23	No	Yes	0	1	4
256	R:R:A180	R:R:P143	1.87	No	No	0	3	4
257	R:R:G147	R:R:I150	1.76	No	Yes	0	3	2
258	R:R:A62	R:R:T84	1.68	No	No	0	4	2
259	R:R:A184	R:R:T140	1.68	No	No	0	4	5
260	R:R:L6	R:R:P3	1.64	No	No	0	5	6
261	R:R:S228	R:R:S275	1.63	No	No	0	7	7
262	R:R:A230	R:R:M200	1.61	No	No	0	5	8
263	R:R:S211	R:R:T212	1.6	No	No	0	5	6
264	R:R:T7	R:R:V8	1.59	No	No	0	4	4
265	R:R:A225	R:R:L203	1.58	No	Yes	0	9	9
266	R:R:C79	R:R:N80	1.57	No	No	0	3	3
267	R:R:I54	R:R:S55	1.55	No	No	0	6	8
268	R:R:I190	R:R:V186	1.54	No	No	0	4	3
269	R:R:F252	R:R:G249	1.51	No	No	0	2	5
270	R:R:L191	R:R:S97	1.5	No	No	0	5	8
271	R:R:L191	R:R:S195	1.5	No	No	0	5	8
272	R:R:L19	R:R:V15	1.49	No	No	0	6	4
273	R:R:L203	R:R:V107	1.49	Yes	No	0	9	9
274	R:R:L270	R:R:T274	1.47	Yes	No	0	7	4
275	R:R:N148	R:R:T82	1.46	No	No	0	3	1
276	R:R:Q206	R:R:S109	1.44	No	No	0	5	7
277	R:R:Q208	R:R:T204	1.42	No	No	0	6	6
278	R:R:G33	R:R:W36	1.41	No	No	0	4	6
279	R:R:I150	R:R:Q151	1.37	Yes	No	0	2	3
280	R:R:I152	R:R:Q153	1.37	No	No	0	2	3
281	R:R:F110	R:R:S108	1.32	No	No	0	8	7
282	R:R:R41	R:R:V39	1.31	No	No	0	5	5
283	R:R:E171	R:R:N172	1.31	No	No	0	3	4
284	R:R:Q175	R:R:Q179	1.28	No	No	0	1	4
285	R:R:V77	R:R:Y76	1.26	No	No	0	3	2
286	R:R:F233	R:R:I234	1.26	No	No	0	7	5
287	R:R:L116	R:R:R119	1.21	No	No	0	6	9
288	R:R:L125	R:R:R124	1.21	No	No	0	6	5
289	R:R:I150	R:R:Y149	1.21	Yes	No	0	2	3
290	R:R:I114	R:R:W117	1.17	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F10	9.71	4	3	5
2	R:R:I13	4.35	4	3	7
3	R:R:Y14	6.044	5	1	4
4	R:R:E17	3.105	4	0	8
5	R:R:S18	5.08	4	0	6
6	R:R:D46	10.76	4	5	9
7	R:R:I48	5.225	4	2	9
8	R:R:R56	9.915	4	1	9
9	R:R:F57	5.235	4	4	6
10	R:R:Q60	8.36	4	0	7
11	R:R:S63	6.122	5	1	5
12	R:R:N66	4.615	4	0	5
13	R:R:N67	8.062	5	1	3
14	R:R:Y71	9.185	4	1	2
15	R:R:W85	12.92	6	1	5
16	R:R:F87	8.275	4	0	7
17	R:R:N89	7.8175	4	1	8
18	R:R:L91	5.4575	4	0	6
19	R:R:F93	7.71	6	1	6
20	R:R:L98	5.8725	4	2	6
21	R:R:F102	8.298	5	2	8
22	R:R:F126	6.57667	6	2	7
23	R:R:T137	6.455	4	0	8
24	R:R:I150	2.34	4	0	2
25	R:R:P188	8.9	4	0	8
26	R:R:F192	9.7025	4	1	8
27	R:R:T196	5.89	4	1	7
28	R:R:L203	3.2825	4	0	9
29	R:R:M219	4.1275	4	7	7
30	R:R:R222	8.175	4	7	9
31	R:R:F236	12.966	5	1	7
32	R:R:Y239	7.296	5	1	7
33	R:R:F240	11.9625	4	1	6
34	R:R:L258	6.2175	4	1	2
35	R:R:W259	13.3875	4	1	3
36	R:R:W261	5.6625	4	0	4
37	R:R:E262	9.722	5	1	3
38	R:R:V265	6.0575	4	1	4
39	R:R:Y266	8.0625	8	1	4
40	R:R:L270	3.5625	4	0	7
41	R:R:H272	8.49	6	1	9
42	R:R:L276	4.485	4	1	9
43	R:R:L283	4.6925	4	0	9
44	L:L:?1	11.4956	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:L6	15.0589	7.31	Yes	No	0	5	5
2	R:R:L6	R:R:P3	12.0702	1.64	No	No	0	5	6
3	R:R:F10	R:R:I13	20.9574	3.77	Yes	Yes	3	5	7
4	R:R:E17	R:R:I13	29.8202	4.1	Yes	Yes	0	8	7
5	R:R:E17	R:R:L270	38.5312	2.65	Yes	Yes	0	8	7
6	R:R:I21	R:R:L270	49.9757	5.71	No	Yes	0	8	7
7	R:R:I21	R:R:Q60	55.6251	12.35	No	Yes	0	8	7
8	R:R:Q60	R:R:S18	12.1492	4.33	Yes	Yes	0	7	6
9	R:R:S18	R:R:Y14	17.7621	5.09	Yes	Yes	0	6	4
10	R:R:N67	R:R:Y14	10.9586	4.65	Yes	Yes	1	3	4
11	R:R:L258	R:R:N67	41.1068	6.87	Yes	Yes	1	2	3
12	R:R:L258	R:R:W259	16.5897	7.97	Yes	Yes	1	2	3
13	R:R:Q60	R:R:Y266	76.7343	11.27	Yes	Yes	0	7	4
14	R:R:Y14	R:R:Y266	19.1471	9.93	Yes	Yes	1	4	4
15	R:R:N67	R:R:S63	12.4347	4.47	Yes	Yes	1	3	5
16	R:R:E262	R:R:Y266	11.3777	5.61	Yes	Yes	1	3	4
17	L:L:?1	R:R:Y266	43.8768	6.17	Yes	Yes	1	0	4
18	L:L:?1	R:R:N67	17.507	7.23	Yes	Yes	1	0	3
19	R:R:I22	R:R:Q60	14.5001	5.49	No	Yes	0	7	7
20	R:R:I269	R:R:Y266	100	6.04	No	Yes	0	8	4
21	R:R:I269	R:R:R56	95.8693	10.02	No	Yes	0	8	9
22	R:R:H272	R:R:R56	92.0119	14.67	Yes	Yes	1	9	9
23	R:R:H272	R:R:L276	99.2225	5.14	Yes	Yes	1	9	9
24	R:R:L276	R:R:L99	97.473	4.15	Yes	No	0	9	9
25	R:R:L99	R:R:Y103	25.2521	12.89	No	No	0	9	9
26	R:R:F102	R:R:Y103	23.5816	4.13	Yes	No	0	8	9
27	R:R:F102	R:R:V45	21.826	6.55	Yes	No	0	8	5
28	R:R:P281	R:R:V45	19.7303	3.53	No	No	0	7	5
29	R:R:P281	R:R:S280	17.586	3.56	No	No	0	7	9
30	R:R:L283	R:R:S280	13.2608	4.5	Yes	No	0	9	9
31	R:R:D46	R:R:L42	22.2877	12.21	Yes	No	0	9	7
32	R:R:L42	R:R:W36	24.4502	13.67	No	No	0	7	6
33	R:R:M47	R:R:W36	28.7389	5.82	No	No	0	5	6
34	R:R:F126	R:R:M47	32.9243	3.73	Yes	No	0	7	5
35	R:R:F126	R:R:I48	71.9779	3.77	Yes	Yes	2	7	9
36	R:R:I48	R:R:L99	71.1031	7.14	Yes	No	0	9	9
37	R:R:D46	R:R:T282	11.2016	11.56	Yes	No	5	9	8
38	R:R:L52	R:R:R56	12.2525	8.5	No	Yes	1	9	9
39	R:R:L52	R:R:L95	11.2987	5.54	No	No	0	9	7
40	R:R:L95	R:R:S51	11.967	10.51	No	No	0	7	7
41	R:R:L130	R:R:S51	10.503	4.5	No	No	0	8	7
42	R:R:L91	R:R:L95	15.308	4.15	Yes	No	0	6	7
43	R:R:L59	R:R:W85	10.9829	12.53	No	Yes	0	5	5
44	R:R:W85	R:R:Y266	16.4196	7.72	Yes	Yes	1	5	4
45	L:L:?1	R:R:N66	43.8039	7.23	Yes	Yes	0	0	5
46	R:R:N66	R:R:N80	11.645	4.09	Yes	No	0	5	3
47	R:R:N66	R:R:T82	26.8133	4.39	Yes	No	0	5	1
48	R:R:C79	R:R:N80	10.017	1.57	No	No	0	3	3
49	R:R:L258	R:R:Y71	16.3346	7.03	Yes	Yes	1	2	2
50	L:L:?1	R:R:E86	12.6655	11.33	Yes	No	0	0	4
51	R:R:E86	R:R:H181	11.3413	17.23	No	No	0	4	2
52	R:R:N89	R:R:W85	42.4918	10.17	Yes	Yes	1	8	5
53	R:R:V265	R:R:Y266	24.0129	6.31	Yes	Yes	1	4	4
54	R:R:F87	R:R:F88	10.1021	8.57	Yes	No	0	7	4
55	R:R:F87	R:R:T137	14.2206	7.78	Yes	Yes	0	7	8
56	R:R:F93	R:R:N89	37.7536	7.25	Yes	Yes	1	6	8
57	R:R:F93	R:R:Y239	37.1522	5.16	Yes	Yes	1	6	7
58	R:R:V265	R:R:Y239	31.4543	3.79	Yes	Yes	1	4	7
59	R:R:I269	R:R:Y239	21.0363	8.46	No	Yes	0	8	7
60	R:R:F93	R:R:P188	19.4812	4.33	Yes	Yes	0	6	8
61	R:R:F236	R:R:F93	66.45	16.08	Yes	Yes	1	7	6
62	R:R:F236	R:R:H272	41.5077	9.05	Yes	Yes	1	7	9
63	R:R:F192	R:R:N96	24.839	8.46	Yes	No	1	8	7
64	R:R:H272	R:R:N96	25.8413	8.93	Yes	No	1	9	7
65	R:R:F192	R:R:F236	74.0433	16.08	Yes	Yes	1	8	7
66	R:R:F192	R:R:T196	87.4074	7.78	Yes	Yes	1	8	7
67	R:R:K205	R:R:Q206	12.1917	4.07	No	No	0	5	5
68	R:R:Q206	R:R:R222	17.9869	11.68	No	Yes	0	5	9
69	R:R:L203	R:R:R222	46.987	7.29	Yes	Yes	0	9	9
70	R:R:L203	R:R:L226	60.8735	2.77	Yes	No	0	9	7
71	R:R:L226	R:R:M200	69.1228	4.24	No	No	0	7	8
72	R:R:M200	R:R:T196	74.7115	3.01	No	Yes	0	8	7
73	R:R:I105	R:R:I122	36.8849	4.42	No	No	0	7	8
74	R:R:F126	R:R:I122	40.7484	3.77	Yes	No	0	7	8
75	R:R:I114	R:R:W117	13.516	1.17	No	No	0	4	6
76	R:R:W117	R:R:W120	26.6007	5.62	No	No	0	6	4
77	R:R:L116	R:R:W120	28.7389	10.25	No	No	0	6	4
78	R:R:L116	R:R:R119	30.865	1.21	No	No	0	6	9
79	R:R:L123	R:R:R119	32.9729	2.43	No	No	0	7	9
80	R:R:I105	R:R:L123	35.0686	2.85	No	No	0	7	7
81	R:R:R121	R:R:W117	11.2927	14.99	No	No	0	8	6
82	R:R:N148	R:R:T82	25.2946	1.46	No	No	0	3	1
83	R:R:N148	R:R:Q151	23.9278	5.28	No	No	0	3	3
84	R:R:I150	R:R:Q151	22.397	1.37	Yes	No	0	2	3
85	R:R:F178	R:R:I248	12.8052	5.02	No	No	0	4	4
86	R:R:F252	R:R:I248	19.2443	17.58	No	No	0	2	4
87	R:R:F252	R:R:I245	25.6348	5.02	No	No	0	2	5
88	R:R:I245	R:R:W261	28.7936	5.87	No	Yes	0	5	4
89	R:R:T242	R:R:W261	25.9385	8.49	No	Yes	0	6	4
90	R:R:T242	R:R:V265	28.1618	9.52	No	Yes	0	6	4
91	R:R:T246	R:R:W261	15.8851	6.06	No	Yes	0	4	4
92	L:L:?1	R:R:T246	17.2519	6.79	Yes	No	0	0	4
93	R:R:F233	R:R:T196	12.1917	6.49	No	Yes	0	7	7
94	R:R:M219	R:R:R222	20.9331	4.96	Yes	Yes	7	7	9
95	R:R:H210	R:R:M219	11.9913	3.94	No	Yes	0	6	7
96	R:R:H272	R:R:V235	11.323	4.15	Yes	No	0	9	7
97	R:R:S18	R:R:V15	13.4188	3.23	Yes	No	0	6	4
98	R:R:L91	R:R:T137	12.1735	5.9	Yes	Yes	0	6	8
99	L:L:?1	R:R:W85	25.2521	37.46	Yes	Yes	1	0	5
100	R:R:I48	R:R:L130	10.2053	4.28	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S63	R:R:Y14	3.82	1	Yes	Yes	5	4	1	2
R:R:N67	R:R:Y14	4.65	1	Yes	Yes	3	4	1	2
R:R:E262	R:R:Y14	6.73	1	Yes	Yes	3	4	1	2
R:R:Y14	R:R:Y266	9.93	1	Yes	Yes	4	4	2	1
R:R:L59	R:R:W85	12.53	0	No	Yes	5	5	2	1
R:R:Q60	R:R:Y266	11.27	0	Yes	Yes	7	4	2	1
R:R:N67	R:R:S63	4.47	1	Yes	Yes	3	5	1	1
R:R:S63	R:R:W85	4.94	1	Yes	Yes	5	5	1	1
R:R:S63	R:R:Y266	11.45	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:S63	5.93	1	Yes	Yes	0	5	0	1
R:R:N66	R:R:N80	4.09	0	Yes	No	5	3	1	2
R:R:N66	R:R:T82	4.39	0	Yes	No	5	1	1	2
L:L:?1	R:R:N66	7.23	1	Yes	Yes	0	5	0	1
R:R:L258	R:R:N67	6.87	1	Yes	Yes	2	3	2	1
R:R:E262	R:R:N67	17.09	1	Yes	Yes	3	3	1	1
L:L:?1	R:R:N67	7.23	1	Yes	Yes	0	3	0	1
R:R:N89	R:R:W85	10.17	1	Yes	Yes	8	5	2	1
R:R:I243	R:R:W85	4.7	1	No	Yes	3	5	2	1
R:R:W85	R:R:Y266	7.72	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:W85	37.46	1	Yes	Yes	0	5	0	1
R:R:E86	R:R:H181	17.23	0	No	No	4	2	1	2
L:L:?1	R:R:E86	11.33	1	Yes	No	0	4	0	1
R:R:I243	R:R:V265	4.61	1	No	Yes	3	4	2	2
R:R:T246	R:R:W261	6.06	0	No	Yes	4	4	1	2
L:L:?1	R:R:T246	6.79	1	Yes	No	0	4	0	1
L:L:?1	R:R:I247	5.63	1	Yes	No	0	4	0	1
R:R:E262	R:R:Y266	5.61	1	Yes	Yes	3	4	1	1
L:L:?1	R:R:E262	15.69	1	Yes	Yes	0	3	0	1
R:R:V265	R:R:Y266	6.31	1	Yes	Yes	4	4	2	1
R:R:I269	R:R:Y266	6.04	0	No	Yes	8	4	2	1
L:L:?1	R:R:Y266	6.17	1	Yes	Yes	0	4	0	1
R:R:E262	R:R:R255	3.49	1	Yes	No	3	5	1	2
R:R:L81	R:R:N66	2.75	0	No	Yes	2	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K6L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	256
Number of Links	290
Number of Hubs	44
Number of Links mediated by Hubs	152
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	52451
Length Of Smallest Path	3
Average Path Length	13.0123
Length of Longest Path	31
Minimum Path Strength	1.29
Average Path Strength	7.17937
Maximum Path Strength	24.995
Minimum Path Correlation	0.7
Average Path Correlation	0.931133
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	52.3156
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.0417
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • taste receptor activity • molecular transducer activity • bitter taste receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled receptor activity • multicellular organismal process • system process • nervous system process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cell surface • external side of plasma membrane • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network • endoplasmic reticulum • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SA0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SA0
Name	Salicin
Synonyms	D-salicin
Identifier
Formula	C13 H18 O7
Molecular Weight	286.278
SMILES
PubChem	439503
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	5
Total Bonds	39
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV7
Sequence	>9K6L_nogp_Chain_R I P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R R L M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N L N Y V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S S F T H H I F L W L R W R I L R L F P W I L L G L M I T C V T I I P S A I G N Y I Q I Q L L E N F H Q Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H C N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F D K R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K R I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K6L	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi2/β1/γ2	2.77	2025-04-02	To be published
	9K6L (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.77	2025-04-02	To be published
	9KPD	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	chim(Gs-CtGt3)/β1/γ2	2.84	2025-04-02	To be published
	9KPD (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.84	2025-04-02	To be published
	9KPE	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.35	2025-04-02	To be published
	9KPE (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.35	2025-04-02	To be published
	9KPF	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.15	2025-04-02	To be published
	9KPF (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.15	2025-04-02	To be published

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