psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I2	R:R:P3	5.08	No	No	0	6	6
2	R:R:I2	R:R:T7	3.04	No	No	0	6	4
3	R:R:I2	R:R:W257	7.05	No	No	0	6	3
4	R:R:P3	R:R:Q5	7.9	No	No	0	6	6
5	R:R:L6	R:R:P3	3.28	No	No	0	5	6
6	R:R:F10	R:R:L6	7.31	No	No	0	5	5
7	R:R:T7	R:R:W259	3.64	No	Yes	0	4	3
8	R:R:F9	R:R:I13	7.54	No	No	0	5	7
9	R:R:F10	R:R:V260	14.42	No	No	0	5	4
10	R:R:M11	R:R:V15	3.04	No	No	0	4	4
11	R:R:M11	R:R:W259	10.47	No	Yes	0	4	3
12	R:R:E17	R:R:I13	4.1	Yes	No	0	8	7
13	R:R:E17	R:R:Y14	3.37	Yes	Yes	0	8	4
14	R:R:Q60	R:R:Y14	3.38	Yes	Yes	1	7	4
15	R:R:S63	R:R:Y14	3.82	Yes	Yes	1	5	4
16	R:R:M64	R:R:Y14	3.59	Yes	Yes	1	3	4
17	R:R:N67	R:R:Y14	9.3	No	Yes	1	3	4
18	R:R:E262	R:R:Y14	14.59	Yes	Yes	1	3	4
19	R:R:Y14	R:R:Y266	15.89	Yes	Yes	1	4	4
20	R:R:S18	R:R:V15	3.23	No	No	0	6	4
21	R:R:A263	R:R:E17	4.53	No	Yes	0	5	8
22	R:R:A267	R:R:E17	4.53	No	Yes	0	6	8
23	R:R:M64	R:R:S18	6.13	Yes	No	0	3	6
24	R:R:Q24	R:R:T20	4.25	No	No	0	7	5
25	R:R:L270	R:R:T20	5.9	No	No	0	7	5
26	R:R:I21	R:R:Q60	12.35	No	Yes	0	8	7
27	R:R:I21	R:R:I269	5.89	No	No	0	8	8
28	R:R:I21	R:R:S273	3.1	No	No	0	8	9
29	R:R:Q24	R:R:S273	7.22	No	No	0	7	9
30	R:R:G53	R:R:S25	3.71	No	No	0	8	9
31	R:R:F57	R:R:S25	11.89	No	No	0	6	9
32	R:R:F57	R:R:S26	6.61	No	No	0	6	8
33	R:R:I28	R:R:M277	10.2	No	No	0	9	9
34	R:R:I50	R:R:V29	3.07	No	No	0	6	6
35	R:R:F57	R:R:V29	5.24	No	No	0	6	6
36	R:R:R34	R:R:V31	6.54	No	No	0	4	8
37	R:R:I286	R:R:V31	4.61	Yes	No	0	5	8
38	R:R:I50	R:R:L32	9.99	No	No	0	6	8
39	R:R:Q38	R:R:R34	3.5	No	No	0	6	4
40	R:R:E35	R:R:Q38	11.47	Yes	No	0	7	6
41	R:R:E35	R:R:V39	4.28	Yes	No	0	7	5
42	R:R:E35	R:R:R285	9.3	Yes	No	2	7	6
43	R:R:E35	R:R:I286	6.83	Yes	Yes	2	7	5
44	R:R:R40	R:R:W36	8	No	No	0	7	6
45	R:R:L42	R:R:W36	11.39	No	No	0	7	6
46	R:R:D46	R:R:L42	10.86	Yes	No	0	9	7
47	R:R:L42	R:R:M47	7.07	No	Yes	0	7	5
48	R:R:D46	R:R:M43	11.09	Yes	No	2	9	7
49	R:R:M43	R:R:P281	3.35	No	Yes	2	7	7
50	R:R:F102	R:R:P44	8.67	Yes	No	3	8	6
51	R:R:F126	R:R:P44	11.56	Yes	No	3	7	6
52	R:R:F102	R:R:V45	5.24	Yes	No	0	8	5
53	R:R:P281	R:R:V45	3.53	Yes	No	0	7	5
54	R:R:D46	R:R:P281	6.44	Yes	Yes	2	9	7
55	R:R:D46	R:R:T282	10.12	Yes	Yes	2	9	8
56	R:R:F126	R:R:M47	3.73	Yes	Yes	0	7	5
57	R:R:M47	R:R:P127	10.06	Yes	No	0	5	7
58	R:R:L130	R:R:M47	4.24	No	Yes	0	8	5
59	R:R:I48	R:R:L98	7.14	No	No	3	9	6
60	R:R:F126	R:R:I48	6.28	Yes	No	3	7	9
61	R:R:L49	R:R:S280	3	No	No	0	8	9
62	R:R:L95	R:R:S51	3	No	No	0	7	7
63	R:R:L52	R:R:R56	6.07	No	Yes	1	9	9
64	R:R:L52	R:R:T92	4.42	No	No	1	9	8
65	R:R:L52	R:R:L95	6.92	No	No	0	9	7
66	R:R:G53	R:R:R56	3	No	Yes	0	8	9
67	R:R:L91	R:R:S55	3	No	Yes	0	6	8
68	R:R:S55	R:R:T92	3.2	Yes	No	0	8	8
69	R:R:L95	R:R:S55	4.5	No	Yes	0	7	8
70	R:R:R56	R:R:T92	6.47	Yes	No	1	9	8
71	R:R:I269	R:R:R56	11.27	No	Yes	0	8	9
72	R:R:H272	R:R:R56	12.41	Yes	Yes	1	9	9
73	R:R:C58	R:R:F88	18.15	No	No	0	2	4
74	R:R:L59	R:R:W85	10.25	No	Yes	0	5	5
75	R:R:Q60	R:R:S63	5.78	Yes	Yes	1	7	5
76	R:R:M64	R:R:Q60	4.08	Yes	Yes	1	3	7
77	R:R:Q60	R:R:Y266	11.27	Yes	Yes	1	7	4
78	R:R:M64	R:R:W61	3.49	Yes	No	0	3	3
79	R:R:L65	R:R:W61	6.83	No	No	0	4	3
80	R:R:A62	R:R:W85	3.89	No	Yes	0	4	5
81	R:R:M64	R:R:S63	3.07	Yes	Yes	1	3	5
82	R:R:S63	R:R:Y266	11.45	Yes	Yes	1	5	4
83	R:R:L65	R:R:N66	4.12	No	No	0	4	5
84	R:R:L65	R:R:L81	5.54	No	No	0	4	2
85	R:R:N66	R:R:W85	3.39	No	Yes	1	5	5
86	L:L:?1	R:R:N66	8.13	Yes	No	1	0	5
87	R:R:N67	R:R:W259	9.04	No	Yes	0	3	3
88	R:R:E262	R:R:N67	14.46	Yes	No	1	3	3
89	R:R:C69	R:R:C79	7.28	No	No	0	3	3
90	R:R:F72	R:R:Y71	14.44	No	No	0	3	2
91	R:R:W259	R:R:Y71	14.47	Yes	No	0	3	2
92	R:R:F72	R:R:L74	3.65	No	No	0	3	4
93	R:R:N73	R:R:Y76	5.81	No	No	0	3	2
94	R:R:N75	R:R:V77	8.87	No	No	0	2	3
95	R:R:C79	R:R:Y76	5.38	No	No	0	3	2
96	R:R:N80	R:R:Y76	8.14	No	No	0	3	2
97	R:R:L81	R:R:T84	8.84	No	No	0	2	2
98	L:L:?1	R:R:T82	4.85	Yes	No	0	0	1
99	R:R:I83	R:R:N148	9.91	No	No	0	4	3
100	R:R:N89	R:R:W85	11.3	Yes	Yes	1	8	5
101	R:R:W85	R:R:Y239	4.82	Yes	Yes	1	5	7
102	R:R:I243	R:R:W85	5.87	Yes	Yes	1	3	5
103	R:R:W85	R:R:Y266	8.68	Yes	Yes	1	5	4
104	L:L:?1	R:R:W85	40.45	Yes	Yes	1	0	5
105	R:R:E86	R:R:I90	4.1	Yes	No	0	4	6
106	R:R:E86	R:R:H181	14.77	Yes	Yes	0	4	2
107	R:R:E86	R:R:L185	3.98	Yes	No	0	4	5
108	L:L:?1	R:R:E86	4.36	Yes	Yes	0	0	4
109	R:R:F87	R:R:F88	11.79	Yes	No	0	7	4
110	R:R:F87	R:R:T137	6.49	Yes	Yes	0	7	8
111	R:R:C138	R:R:F87	4.19	No	Yes	0	3	7
112	R:R:F87	R:R:I141	7.54	Yes	No	0	7	5
113	R:R:F93	R:R:N89	7.25	Yes	Yes	1	6	8
114	R:R:L185	R:R:N89	5.49	No	Yes	0	5	8
115	R:R:N89	R:R:Y239	6.98	Yes	Yes	1	8	7
116	R:R:I90	R:R:T137	4.56	No	Yes	0	6	8
117	R:R:L91	R:R:T137	11.79	No	Yes	0	6	8
118	R:R:F93	R:R:P188	4.33	Yes	No	1	6	8
119	R:R:F189	R:R:F93	4.29	No	Yes	1	6	6
120	R:R:F236	R:R:F93	17.15	Yes	Yes	1	7	6
121	R:R:F93	R:R:Y239	5.16	Yes	Yes	1	6	7
122	R:R:F240	R:R:F93	6.43	Yes	Yes	1	6	6
123	R:R:I136	R:R:W94	7.05	No	Yes	0	4	9
124	R:R:T137	R:R:W94	3.64	Yes	Yes	0	8	9
125	R:R:I187	R:R:W94	3.52	No	Yes	1	5	9
126	R:R:P188	R:R:W94	22.97	No	Yes	1	8	9
127	R:R:L99	R:R:N96	5.49	No	Yes	0	9	7
128	R:R:F192	R:R:N96	10.87	Yes	Yes	1	8	7
129	R:R:F236	R:R:N96	19.33	Yes	Yes	1	7	7
130	R:R:H272	R:R:N96	8.93	Yes	Yes	1	9	7
131	R:R:L191	R:R:S97	9.01	No	No	0	5	8
132	R:R:F126	R:R:L98	7.31	Yes	No	3	7	6
133	R:R:C133	R:R:L98	3.17	No	No	0	8	6
134	R:R:L99	R:R:Y103	12.89	No	No	0	9	9
135	R:R:F192	R:R:T100	10.38	Yes	No	1	8	8
136	R:R:S195	R:R:T100	6.4	No	No	0	8	8
137	R:R:T100	R:R:T196	3.14	No	Yes	1	8	7
138	R:R:L191	R:R:V101	4.47	No	No	0	5	7
139	R:R:F102	R:R:I105	3.77	Yes	No	0	8	7
140	R:R:F102	R:R:K106	7.44	Yes	No	0	8	9
141	R:R:F102	R:R:F126	8.57	Yes	Yes	3	8	7
142	R:R:L199	R:R:Y103	3.52	No	No	0	9	9
143	R:R:C104	R:R:F198	4.19	No	No	0	8	7
144	R:R:K106	R:R:R119	9.9	No	No	0	9	9
145	R:R:K106	R:R:L123	4.23	No	No	0	9	7
146	R:R:F110	R:R:S108	3.96	No	No	0	8	7
147	R:R:F110	R:R:F115	7.5	No	No	0	8	9
148	R:R:F110	R:R:F198	5.36	No	No	0	8	7
149	R:R:H112	R:R:I114	9.28	No	No	0	7	4
150	R:R:F115	R:R:H112	3.39	No	No	0	9	7
151	R:R:R121	R:R:W117	9	No	No	0	8	6
152	R:R:I122	R:R:L118	5.71	No	No	0	8	8
153	R:R:R124	R:R:W120	4	No	No	0	5	4
154	R:R:R121	R:R:R124	12.79	No	No	0	8	5
155	R:R:L125	R:R:R121	10.93	No	No	0	6	8
156	R:R:L125	R:R:W128	6.83	No	No	0	6	3
157	R:R:L131	R:R:W128	3.42	No	No	0	5	3
158	R:R:I141	R:R:S144	6.19	No	No	0	5	3
159	R:R:I142	R:R:P143	3.39	No	No	0	5	4
160	R:R:N148	R:R:S144	4.47	No	No	5	3	3
161	R:R:H181	R:R:S144	11.16	Yes	No	5	2	3
162	R:R:G147	R:R:Q177	4.93	No	Yes	0	3	1
163	R:R:H181	R:R:N148	5.1	Yes	No	5	2	3
164	R:R:Q153	R:R:Y149	7.89	No	No	0	3	3
165	R:R:F173	R:R:I150	7.54	Yes	No	0	4	2
166	R:R:Q151	R:R:Q177	7.68	No	Yes	0	3	1
167	R:R:I152	R:R:T156	3.04	No	No	0	2	1
168	R:R:Q153	R:R:T156	5.67	No	No	0	3	1
169	R:R:F173	R:R:L154	4.87	Yes	No	0	4	2
170	R:R:E171	R:R:N172	11.83	No	No	0	3	4
171	R:R:E171	R:R:H174	3.69	No	No	0	3	3
172	R:R:F178	R:R:Q179	10.54	Yes	No	0	4	4
173	R:R:F178	R:R:T182	5.19	Yes	No	1	4	4
174	R:R:F178	R:R:I247	6.28	Yes	Yes	1	4	4
175	R:R:F178	R:R:I248	3.77	Yes	Yes	0	4	4
176	R:R:I247	R:R:T182	3.04	Yes	No	1	4	4
177	R:R:I187	R:R:V183	3.07	No	No	0	5	5
178	R:R:I247	R:R:L185	5.71	Yes	No	0	4	5
179	R:R:I190	R:R:V186	3.07	No	No	0	4	3
180	R:R:F240	R:R:V186	7.87	Yes	No	0	6	3
181	R:R:I187	R:R:P188	3.39	No	No	1	5	8
182	R:R:F189	R:R:T237	9.08	No	No	0	6	5
183	R:R:F189	R:R:F240	34.29	No	Yes	1	6	6
184	R:R:L191	R:R:S195	3	No	No	0	5	8
185	R:R:F192	R:R:T196	9.08	Yes	Yes	1	8	7
186	R:R:F192	R:R:L232	4.87	Yes	No	0	8	8
187	R:R:F192	R:R:F233	7.5	Yes	Yes	1	8	7
188	R:R:F192	R:R:F236	6.43	Yes	Yes	1	8	7
189	R:R:I197	R:R:L193	4.28	No	No	0	5	6
190	R:R:M200	R:R:T196	3.01	No	Yes	0	8	7
191	R:R:L229	R:R:T196	4.42	No	Yes	0	7	7
192	R:R:F233	R:R:T196	6.49	Yes	Yes	1	7	7
193	R:R:L199	R:R:S202	3	No	No	0	9	9
194	R:R:L199	R:R:L229	5.54	No	No	0	9	7
195	R:R:L226	R:R:M200	4.24	No	No	0	7	8
196	R:R:L203	R:R:Q206	3.99	No	No	0	9	5
197	R:R:A225	R:R:L203	3.15	No	No	0	9	9
198	R:R:L203	R:R:L226	5.54	No	No	0	9	7
199	R:R:H210	R:R:Q206	6.18	No	No	4	6	5
200	R:R:Q206	R:R:R222	10.51	No	Yes	4	5	9
201	R:R:I207	R:R:M219	5.83	No	No	4	8	7
202	R:R:I207	R:R:R222	6.26	No	Yes	4	8	9
203	R:R:H209	R:R:H210	10.75	No	No	0	5	6
204	R:R:H210	R:R:R222	6.77	No	Yes	4	6	9
205	R:R:G213	R:R:H214	3.18	No	No	0	7	5
206	R:R:C215	R:R:M219	3.24	No	No	0	6	7
207	R:R:N216	R:R:P217	3.26	No	No	0	8	5
208	R:R:R222	R:R:S218	3.95	Yes	No	0	9	8
209	R:R:M219	R:R:R222	6.2	No	Yes	4	7	9
210	R:R:H272	R:R:L232	5.14	Yes	No	0	9	8
211	R:R:F233	R:R:T237	11.67	Yes	No	0	7	5
212	R:R:M271	R:R:V235	7.61	No	No	0	4	7
213	R:R:H272	R:R:V235	4.15	Yes	No	0	9	7
214	R:R:F236	R:R:H272	9.05	Yes	Yes	1	7	9
215	R:R:F268	R:R:S238	7.93	Yes	No	0	5	6
216	R:R:I243	R:R:Y239	12.09	Yes	Yes	1	3	7
217	R:R:F268	R:R:Y239	3.09	Yes	Yes	0	5	7
218	R:R:T242	R:R:W261	6.06	No	Yes	1	6	4
219	R:R:T242	R:R:V265	4.76	No	Yes	1	6	4
220	R:R:F268	R:R:T242	3.89	Yes	No	0	5	6
221	R:R:I243	R:R:T246	4.56	Yes	Yes	0	3	4
222	R:R:I243	R:R:V265	3.07	Yes	Yes	1	3	4
223	R:R:I245	R:R:W261	7.05	No	Yes	0	5	4
224	R:R:K254	R:R:T246	3	No	Yes	0	3	4
225	R:R:T246	R:R:W261	4.85	Yes	Yes	0	4	4
226	L:L:?1	R:R:T246	4.85	Yes	Yes	0	0	4
227	L:L:?1	R:R:I247	3.76	Yes	Yes	1	0	4
228	R:R:I248	R:R:L251	5.71	Yes	No	0	4	1
229	R:R:F252	R:R:W257	8.02	No	No	0	2	3
230	R:R:F252	R:R:W261	20.04	No	Yes	0	2	4
231	R:R:D253	R:R:R255	3.57	No	No	0	1	5
232	R:R:C256	R:R:D253	6.22	No	No	0	1	1
233	R:R:C256	R:R:W257	9.14	No	No	0	1	3
234	R:R:L258	R:R:W259	7.97	No	Yes	0	2	3
235	R:R:V265	R:R:W261	4.9	Yes	Yes	1	4	4
236	R:R:E262	R:R:Y266	7.86	Yes	Yes	1	3	4
237	L:L:?1	R:R:E262	15.69	Yes	Yes	1	0	3
238	R:R:F264	R:R:F268	10.72	No	Yes	0	4	5
239	R:R:V265	R:R:Y266	8.83	Yes	Yes	1	4	4
240	L:L:?1	R:R:V265	3.92	Yes	Yes	1	0	4
241	R:R:I269	R:R:Y266	6.04	No	Yes	0	8	4
242	L:L:?1	R:R:Y266	7.71	Yes	Yes	1	0	4
243	R:R:F268	R:R:M271	3.73	Yes	No	0	5	4
244	R:R:H272	R:R:L276	5.14	Yes	No	0	9	9
245	R:R:M277	R:R:S280	3.07	No	No	0	9	9
246	R:R:L283	R:R:S280	6.01	No	No	0	9	9
247	R:R:R285	R:R:T282	3.88	No	Yes	2	6	8
248	R:R:I286	R:R:T282	3.04	Yes	Yes	2	5	8
249	R:R:L283	R:R:L287	6.92	No	No	0	9	6
250	R:R:I286	R:R:R285	5.01	Yes	No	2	5	6
251	R:R:L32	R:R:T282	2.95	No	Yes	0	8	8
252	R:R:L278	R:R:T274	2.95	No	No	0	6	4
253	R:R:I105	R:R:I122	2.94	No	No	0	7	8
254	R:R:I12	R:R:M11	2.92	No	No	0	5	4
255	R:R:Q24	R:R:T274	2.83	No	No	0	7	4
256	R:R:C69	R:R:F68	2.79	No	No	0	3	3
257	R:R:L276	R:R:L49	2.77	No	No	0	9	8
258	R:R:L134	R:R:L91	2.77	No	No	0	5	6
259	R:R:I152	R:R:Q151	2.74	No	No	0	2	3
260	R:R:F115	R:R:I105	2.51	No	No	0	9	7
261	R:R:H174	R:R:Q177	2.47	No	Yes	0	3	1
262	R:R:H181	R:R:Q177	2.47	Yes	Yes	0	2	1
263	R:R:H209	R:R:Q208	2.47	No	No	0	5	6
264	R:R:F233	R:R:L193	2.44	Yes	No	0	7	6
265	R:R:F240	R:R:L241	2.44	Yes	No	0	6	4
266	R:R:F240	R:R:L244	2.44	Yes	No	0	6	4
267	R:R:H112	R:R:H113	2.39	No	No	0	7	5
268	R:R:F68	R:R:F72	2.14	No	No	0	3	3
269	R:R:A180	R:R:P143	1.87	No	No	0	3	4
270	R:R:G213	R:R:T212	1.82	No	No	0	7	6
271	R:R:P217	R:R:S218	1.78	No	No	0	5	8
272	R:R:G147	R:R:I146	1.76	No	No	0	3	3
273	R:R:G249	R:R:I248	1.76	No	Yes	0	5	4
274	R:R:G132	R:R:M135	1.75	No	No	0	5	5
275	R:R:A184	R:R:T140	1.68	No	No	0	4	5
276	R:R:K284	R:R:P281	1.67	No	Yes	0	7	7
277	R:R:C133	R:R:I129	1.64	No	No	0	8	7
278	R:R:A184	R:R:I90	1.62	No	No	0	4	6
279	R:R:A230	R:R:M200	1.61	No	No	0	5	8
280	R:R:V231	R:R:V235	1.6	No	No	0	7	7
281	R:R:I22	R:R:S26	1.55	No	No	0	7	8
282	R:R:I54	R:R:S55	1.55	No	Yes	0	6	8
283	R:R:I234	R:R:S238	1.55	No	No	0	5	6
284	R:R:I12	R:R:V8	1.54	No	No	0	5	4
285	R:R:K205	R:R:S202	1.53	No	No	0	5	9
286	R:R:I248	R:R:T250	1.52	Yes	No	0	4	3
287	R:R:L19	R:R:S18	1.5	No	No	0	6	6
288	R:R:L258	R:R:S70	1.5	No	No	0	2	3
289	R:R:L276	R:R:S275	1.5	No	No	0	9	7
290	R:R:L78	R:R:V77	1.49	No	No	0	1	3
291	R:R:L226	R:R:T204	1.47	No	No	0	7	6
292	R:R:A180	R:R:H181	1.46	No	Yes	0	3	2
293	R:R:I12	R:R:L16	1.43	No	No	0	5	5
294	R:R:G33	R:R:W36	1.41	No	No	0	4	6
295	R:R:L27	R:R:L283	1.38	No	No	0	8	9
296	R:R:I4	R:R:Q5	1.37	No	No	0	4	6
297	R:R:R41	R:R:V39	1.31	No	No	0	5	5
298	R:R:R227	R:R:V231	1.31	No	No	0	7	7
299	R:R:F223	R:R:T224	1.3	No	No	0	6	5
300	R:R:R227	R:R:T224	1.29	No	No	0	7	5
301	R:R:S279	R:R:Y103	1.27	No	No	0	7	9
302	R:R:E171	R:R:Q175	1.27	No	No	0	3	1
303	R:R:L116	R:R:R119	1.21	No	No	0	6	9
304	R:R:F173	R:R:N172	1.21	Yes	No	0	4	4
305	R:R:L118	R:R:W117	1.14	No	No	0	8	6
306	R:R:F173	R:R:Y176	1.03	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y14	7.70571	7	1	4
2	R:R:E17	4.1325	4	0	8
3	R:R:E35	7.97	4	2	7
4	R:R:D46	9.6275	4	2	9
5	R:R:M47	6.275	4	0	5
6	R:R:S55	3.0625	4	0	8
7	R:R:R56	7.844	5	1	9
8	R:R:Q60	7.372	5	1	7
9	R:R:S63	6.03	4	1	5
10	R:R:M64	4.072	5	1	3
11	R:R:W85	11.0813	8	1	5
12	R:R:E86	6.8025	4	0	4
13	R:R:F87	7.5025	4	0	7
14	R:R:N89	7.755	4	1	8
15	R:R:F93	7.435	6	1	6
16	R:R:W94	9.295	4	1	9
17	R:R:N96	11.155	4	1	7
18	R:R:F102	6.738	5	3	8
19	R:R:F126	7.49	5	3	7
20	R:R:T137	6.62	4	0	8
21	R:R:F173	3.6625	4	0	4
22	R:R:Q177	4.3875	4	0	1
23	R:R:F178	6.445	4	1	4
24	R:R:H181	6.992	5	5	2
25	R:R:F192	8.18833	6	1	8
26	R:R:T196	5.228	5	1	7
27	R:R:R222	6.738	5	4	9
28	R:R:F233	7.025	4	1	7
29	R:R:F236	12.99	4	1	7
30	R:R:Y239	6.428	5	1	7
31	R:R:F240	10.694	5	1	6
32	R:R:I243	6.3975	4	1	3
33	R:R:T246	4.315	4	0	4
34	R:R:I247	4.6975	4	1	4
35	R:R:I248	3.19	4	0	4
36	R:R:W259	9.118	5	0	3
37	R:R:W261	8.58	5	1	4
38	R:R:E262	13.15	4	1	3
39	R:R:V265	5.096	5	1	4
40	R:R:Y266	9.71625	8	1	4
41	R:R:F268	5.872	5	0	5
42	R:R:H272	7.47	6	1	9
43	R:R:P281	3.7475	4	2	7
44	R:R:T282	4.9975	4	2	8
45	R:R:I286	4.8725	4	2	5
46	L:L:?1	10.4133	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I2	R:R:P3	21.2466	5.08	No	No	0	6	6
2	R:R:L6	R:R:P3	10.6653	3.28	No	No	0	5	6
3	R:R:I2	R:R:T7	10.8632	3.04	No	No	0	6	4
4	R:R:T7	R:R:W259	14.0045	3.64	No	Yes	0	4	3
5	R:R:E17	R:R:Y14	11.1749	3.37	Yes	Yes	0	8	4
6	R:R:N67	R:R:Y14	30.9968	9.3	No	Yes	1	3	4
7	R:R:N67	R:R:W259	73.1338	9.04	No	Yes	0	3	3
8	R:R:M11	R:R:W259	16.092	10.47	No	Yes	0	4	3
9	R:R:E262	R:R:N67	45.3673	14.46	Yes	No	1	3	3
10	R:R:Y14	R:R:Y266	46.0994	15.89	Yes	Yes	1	4	4
11	R:R:E262	R:R:Y266	29.859	7.86	Yes	Yes	1	3	4
12	R:R:I2	R:R:W257	15.5132	7.05	No	No	0	6	3
13	R:R:F252	R:R:W257	23.8288	8.02	No	No	0	2	3
14	R:R:F252	R:R:W261	25.7977	20.04	No	Yes	0	2	4
15	R:R:V265	R:R:W261	16.1266	4.9	Yes	Yes	1	4	4
16	R:R:V265	R:R:Y266	11.7339	8.83	Yes	Yes	1	4	4
17	R:R:I21	R:R:Q60	10.1311	12.35	No	Yes	0	8	7
18	R:R:I21	R:R:S273	13.6483	3.1	No	No	0	8	9
19	R:R:Q24	R:R:S273	11.3975	7.22	No	No	0	7	9
20	R:R:I269	R:R:Y266	91.5558	6.04	No	Yes	0	8	4
21	R:R:G53	R:R:R56	96.4284	3	No	Yes	0	8	9
22	R:R:I269	R:R:R56	100	11.27	No	Yes	0	8	9
23	R:R:G53	R:R:S25	95.1818	3.71	No	No	0	8	9
24	R:R:F57	R:R:S25	93.9253	11.89	No	No	0	6	9
25	R:R:H272	R:R:R56	92.0702	12.41	Yes	Yes	1	9	9
26	R:R:H272	R:R:L276	19.3173	5.14	Yes	No	0	9	9
27	R:R:L276	R:R:L49	15.0928	2.77	No	No	0	9	8
28	R:R:L49	R:R:S280	12.9656	3	No	No	0	8	9
29	R:R:F268	R:R:T242	10.4576	3.89	Yes	No	0	5	6
30	R:R:H272	R:R:V235	12.8321	4.15	Yes	No	0	9	7
31	R:R:F57	R:R:V29	90.0519	5.24	No	No	0	6	6
32	R:R:I50	R:R:V29	88.7559	3.07	No	No	0	6	6
33	R:R:I50	R:R:L32	87.4499	9.99	No	No	0	6	8
34	R:R:L32	R:R:T282	86.1341	2.95	No	Yes	0	8	8
35	R:R:I286	R:R:T282	12.6342	3.04	Yes	Yes	2	5	8
36	R:R:D46	R:R:T282	68.1276	10.12	Yes	Yes	2	9	8
37	R:R:D46	R:R:L42	21.2318	10.86	Yes	No	0	9	7
38	R:R:L42	R:R:M47	15.1373	7.07	No	Yes	0	7	5
39	R:R:D46	R:R:P281	44.0119	6.44	Yes	Yes	2	9	7
40	R:R:F102	R:R:V45	39.4806	5.24	Yes	No	0	8	5
41	R:R:P281	R:R:V45	41.0636	3.53	Yes	No	0	7	5
42	R:R:F126	R:R:M47	10.7841	3.73	Yes	Yes	0	7	5
43	R:R:R56	R:R:T92	11.4321	6.47	Yes	No	1	9	8
44	L:L:?1	R:R:E262	19.9951	15.69	Yes	Yes	1	0	3
45	L:L:?1	R:R:E86	36.9725	4.36	Yes	Yes	0	0	4
46	R:R:E86	R:R:I90	12.8321	4.1	Yes	No	0	4	6
47	R:R:I90	R:R:T137	10.2795	4.56	No	Yes	0	6	8
48	R:R:S55	R:R:T92	10.0223	3.2	Yes	No	0	8	8
49	R:R:W85	R:R:Y266	35.632	8.68	Yes	Yes	1	5	4
50	L:L:?1	R:R:W85	13.5098	40.45	Yes	Yes	1	0	5
51	R:R:C69	R:R:F68	19.5845	2.79	No	No	0	3	3
52	R:R:F68	R:R:F72	23.4727	2.14	No	No	0	3	3
53	R:R:F72	R:R:Y71	31.2194	14.44	No	No	0	3	2
54	R:R:W259	R:R:Y71	35.0779	14.47	Yes	No	0	3	2
55	R:R:C69	R:R:C79	15.6864	7.28	No	No	0	3	3
56	R:R:C79	R:R:Y76	11.7784	5.38	No	No	0	3	2
57	R:R:E86	R:R:H181	37.9471	14.77	Yes	Yes	0	4	2
58	R:R:N89	R:R:W85	22.3745	11.3	Yes	Yes	1	8	5
59	R:R:F268	R:R:Y239	11.9713	3.09	Yes	Yes	0	5	7
60	R:R:E86	R:R:L185	13.2921	3.98	Yes	No	0	4	5
61	L:L:?1	R:R:I247	10.8978	3.76	Yes	Yes	1	0	4
62	R:R:F93	R:R:Y239	35.4192	5.16	Yes	Yes	1	6	7
63	R:R:F93	R:R:P188	12.7974	4.33	Yes	No	1	6	8
64	R:R:F236	R:R:F93	58.5951	17.15	Yes	Yes	1	7	6
65	R:R:F240	R:R:F93	10.977	6.43	Yes	Yes	1	6	6
66	R:R:H272	R:R:N96	29.6661	8.93	Yes	Yes	1	9	7
67	R:R:L99	R:R:N96	10.4873	5.49	No	Yes	0	9	7
68	R:R:F192	R:R:F236	63.5765	6.43	Yes	Yes	1	8	7
69	R:R:F192	R:R:T100	19.164	10.38	Yes	No	1	8	8
70	R:R:S195	R:R:T100	15.9238	6.4	No	No	0	8	8
71	R:R:L191	R:R:S195	11.9565	3	No	No	0	5	8
72	R:R:F192	R:R:T196	72.837	9.08	Yes	Yes	1	8	7
73	R:R:F102	R:R:I105	31.2985	3.77	Yes	No	0	8	7
74	R:R:F115	R:R:I105	14.1825	2.51	No	No	0	9	7
75	R:R:I105	R:R:I122	16.1167	2.94	No	No	0	7	8
76	R:R:I122	R:R:L118	14.5585	5.71	No	No	0	8	8
77	R:R:L118	R:R:W117	12.7727	1.14	No	No	0	8	6
78	R:R:R121	R:R:W117	10.977	9	No	No	0	8	6
79	R:R:H181	R:R:Q177	26.9255	2.47	Yes	Yes	0	2	1
80	R:R:E171	R:R:H174	11.9664	3.69	No	No	0	3	3
81	R:R:H174	R:R:Q177	13.6879	2.47	No	Yes	0	3	1
82	R:R:F178	R:R:I247	11.3727	6.28	Yes	Yes	1	4	4
83	R:R:H272	R:R:L232	24.0069	5.14	Yes	No	0	9	8
84	R:R:F192	R:R:F233	12.8815	7.5	Yes	Yes	1	8	7
85	R:R:F233	R:R:L193	10.7395	2.44	Yes	No	0	7	6
86	R:R:M200	R:R:T196	65.1348	3.01	No	Yes	0	8	7
87	R:R:L226	R:R:M200	57.4573	4.24	No	No	0	7	8
88	R:R:L203	R:R:L226	50.1558	5.54	No	No	0	9	7
89	R:R:L203	R:R:Q206	42.8345	3.99	No	No	0	9	5
90	R:R:H210	R:R:Q206	11.8081	6.18	No	No	4	6	5
91	R:R:Q206	R:R:R222	27.1333	10.51	No	Yes	4	5	9
92	R:R:R222	R:R:S218	11.9119	3.95	Yes	No	0	9	8
93	R:R:I12	R:R:M11	11.8674	2.92	No	No	0	5	4
94	R:R:V231	R:R:V235	10.0074	1.6	No	No	0	7	7
95	R:R:W85	R:R:Y239	25.8224	4.82	Yes	Yes	1	5	7
96	R:R:F93	R:R:N89	33.7373	7.25	Yes	Yes	1	6	8
97	R:R:F236	R:R:H272	34.6129	9.05	Yes	Yes	1	7	9
98	R:R:F192	R:R:N96	22.6713	10.87	Yes	Yes	1	8	7
99	R:R:F192	R:R:L232	22.8345	4.87	Yes	No	0	8	8
100	R:R:Q60	R:R:Y266	12.7183	11.27	Yes	Yes	1	7	4
101	R:R:M64	R:R:Q60	11.8922	4.08	Yes	Yes	1	3	7
102	R:R:I21	R:R:I269	15.6369	5.89	No	No	0	8	8
103	R:R:M64	R:R:S18	19.4361	6.13	Yes	No	0	3	6
104	L:L:?1	R:R:Y266	26.5545	7.71	Yes	Yes	1	0	4
105	R:R:L185	R:R:N89	15.2758	5.49	No	Yes	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q60	R:R:Y14	3.38	1	Yes	Yes	7	4	2	2
R:R:S63	R:R:Y14	3.82	1	Yes	Yes	5	4	2	2
R:R:N67	R:R:Y14	9.3	1	No	Yes	3	4	2	2
R:R:E262	R:R:Y14	14.59	1	Yes	Yes	3	4	1	2
R:R:Y14	R:R:Y266	15.89	1	Yes	Yes	4	4	2	1
R:R:L59	R:R:W85	10.25	0	No	Yes	5	5	2	1
R:R:Q60	R:R:S63	5.78	1	Yes	Yes	7	5	2	2
R:R:Q60	R:R:Y266	11.27	1	Yes	Yes	7	4	2	1
R:R:A62	R:R:W85	3.89	0	No	Yes	4	5	2	1
R:R:S63	R:R:Y266	11.45	1	Yes	Yes	5	4	2	1
R:R:L65	R:R:N66	4.12	0	No	No	4	5	2	1
R:R:N66	R:R:W85	3.39	1	No	Yes	5	5	1	1
L:L:?1	R:R:N66	8.13	1	Yes	No	0	5	0	1
R:R:E262	R:R:N67	14.46	1	Yes	No	3	3	1	2
L:L:?1	R:R:T82	4.85	1	Yes	No	0	1	0	1
R:R:N89	R:R:W85	11.3	1	Yes	Yes	8	5	2	1
R:R:W85	R:R:Y239	4.82	1	Yes	Yes	5	7	1	2
R:R:I243	R:R:W85	5.87	1	Yes	Yes	3	5	2	1
R:R:W85	R:R:Y266	8.68	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:W85	40.45	1	Yes	Yes	0	5	0	1
R:R:E86	R:R:I90	4.1	0	Yes	No	4	6	1	2
R:R:E86	R:R:H181	14.77	0	Yes	Yes	4	2	1	2
R:R:E86	R:R:L185	3.98	0	Yes	No	4	5	1	2
L:L:?1	R:R:E86	4.36	1	Yes	Yes	0	4	0	1
R:R:L185	R:R:N89	5.49	0	No	Yes	5	8	2	2
R:R:N89	R:R:Y239	6.98	1	Yes	Yes	8	7	2	2
R:R:F178	R:R:T182	5.19	1	Yes	No	4	4	2	2
R:R:F178	R:R:I247	6.28	1	Yes	Yes	4	4	2	1
R:R:I247	R:R:T182	3.04	1	Yes	No	4	4	1	2
R:R:I247	R:R:L185	5.71	1	Yes	No	4	5	1	2
R:R:I243	R:R:Y239	12.09	1	Yes	Yes	3	7	2	2
R:R:T242	R:R:W261	6.06	1	No	Yes	6	4	2	2
R:R:T242	R:R:V265	4.76	1	No	Yes	6	4	2	1
R:R:I243	R:R:T246	4.56	1	Yes	Yes	3	4	2	1
R:R:I243	R:R:V265	3.07	1	Yes	Yes	3	4	2	1
R:R:K254	R:R:T246	3	0	No	Yes	3	4	2	1
R:R:T246	R:R:W261	4.85	0	Yes	Yes	4	4	1	2
L:L:?1	R:R:T246	4.85	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I247	3.76	1	Yes	Yes	0	4	0	1
R:R:V265	R:R:W261	4.9	1	Yes	Yes	4	4	1	2
R:R:E262	R:R:Y266	7.86	1	Yes	Yes	3	4	1	1
L:L:?1	R:R:E262	15.69	1	Yes	Yes	0	3	0	1
R:R:V265	R:R:Y266	8.83	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:V265	3.92	1	Yes	Yes	0	4	0	1
R:R:I269	R:R:Y266	6.04	0	No	Yes	8	4	2	1
L:L:?1	R:R:Y266	7.71	1	Yes	Yes	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KPE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	258
Number of Links	306
Number of Hubs	46
Number of Links mediated by Hubs	164
Number of Communities	5
Number of Nodes involved in Communities	55
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	64335
Length Of Smallest Path	3
Average Path Length	13.2299
Length of Longest Path	32
Minimum Path Strength	1.12
Average Path Strength	7.24329
Maximum Path Strength	25.875
Minimum Path Correlation	0.7
Average Path Correlation	0.929146
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	48.2183
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2217
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • taste receptor activity • molecular transducer activity • bitter taste receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled receptor activity • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cell surface • external side of plasma membrane • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network • endoplasmic reticulum
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SA0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SA0
Name	Salicin
Synonyms	D-salicin
Identifier
Formula	C13 H18 O7
Molecular Weight	286.278
SMILES
PubChem	439503
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	5
Total Bonds	39
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV7
Sequence	>9KPE_nogp_Chain_R I P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R R L M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N L N Y V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S S F T H H I F L W L R W R I L R L F P W I L L G L M I T C V T I I P S A I G N Y I Q I Q L L T E N F H Q Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H C N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F D K R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K R I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K6L	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi2/β1/γ2	2.77	2025-04-02	To be published
	9K6L (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.77	2025-04-02	To be published
	9KPD	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	chim(Gs-CtGt3)/β1/γ2	2.84	2025-04-02	To be published
	9KPD (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.84	2025-04-02	To be published
	9KPE	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.35	2025-04-02	To be published
	9KPE (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.35	2025-04-02	To be published
	9KPF	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.15	2025-04-02	To be published
	9KPF (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.15	2025-04-02	To be published

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