psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I2	R:R:P3	3.39	Yes	No	3	6	6
2	R:R:I2	R:R:L6	4.28	Yes	No	3	6	5
3	R:R:I2	R:R:T7	3.04	Yes	No	0	6	4
4	R:R:I2	R:R:W257	9.4	Yes	Yes	0	6	3
5	R:R:L6	R:R:P3	6.57	No	No	3	5	6
6	R:R:I4	R:R:T7	4.56	No	No	0	4	4
7	R:R:F10	R:R:L6	7.31	No	No	0	5	5
8	R:R:F9	R:R:I13	12.56	No	No	0	5	7
9	R:R:F10	R:R:V260	7.87	No	No	0	5	4
10	R:R:F68	R:R:M11	6.22	No	Yes	1	3	4
11	R:R:F72	R:R:M11	9.95	Yes	Yes	1	3	4
12	R:R:M11	R:R:W259	22.1	Yes	Yes	1	4	3
13	R:R:E17	R:R:I13	4.1	No	No	0	8	7
14	R:R:S18	R:R:Y14	5.09	No	Yes	1	6	4
15	R:R:Q60	R:R:Y14	4.51	Yes	Yes	1	7	4
16	R:R:S63	R:R:Y14	3.82	Yes	Yes	1	5	4
17	R:R:M64	R:R:Y14	7.18	Yes	Yes	1	3	4
18	R:R:N67	R:R:Y14	5.81	Yes	Yes	1	3	4
19	R:R:E262	R:R:Y14	19.08	Yes	Yes	1	3	4
20	R:R:Y14	R:R:Y266	14.89	Yes	Yes	1	4	4
21	R:R:A267	R:R:E17	4.53	No	No	0	6	8
22	R:R:Q60	R:R:S18	4.33	Yes	No	1	7	6
23	R:R:M64	R:R:S18	6.13	Yes	No	1	3	6
24	R:R:I21	R:R:Q60	6.86	No	Yes	0	8	7
25	R:R:I21	R:R:L270	4.28	No	Yes	0	8	7
26	R:R:I22	R:R:Q60	5.49	No	Yes	0	7	7
27	R:R:I22	R:R:W61	8.22	No	No	0	7	3
28	R:R:L270	R:R:Q24	3.99	Yes	No	0	7	7
29	R:R:Q24	R:R:S273	5.78	No	No	0	7	9
30	R:R:Q24	R:R:T274	4.25	No	No	0	7	4
31	R:R:F57	R:R:S25	3.96	No	No	0	6	9
32	R:R:I28	R:R:L32	4.28	Yes	Yes	2	9	8
33	R:R:I28	R:R:L49	7.14	Yes	Yes	2	9	8
34	R:R:I28	R:R:M277	4.37	Yes	No	0	9	9
35	R:R:I28	R:R:S280	3.1	Yes	No	2	9	9
36	R:R:L32	R:R:L42	4.15	Yes	Yes	2	8	7
37	R:R:D46	R:R:L32	5.43	Yes	Yes	2	9	8
38	R:R:I50	R:R:L32	7.14	No	Yes	0	6	8
39	R:R:G33	R:R:W36	4.22	No	Yes	0	4	6
40	R:R:E35	R:R:Q38	7.65	No	No	0	7	6
41	R:R:E35	R:R:L42	6.63	No	Yes	2	7	7
42	R:R:E35	R:R:T282	4.23	No	No	2	7	8
43	R:R:R40	R:R:W36	13	No	Yes	0	7	6
44	R:R:L42	R:R:W36	6.83	Yes	Yes	0	7	6
45	R:R:I50	R:R:W36	5.87	No	Yes	0	6	6
46	R:R:Q38	R:R:V39	5.73	No	No	0	6	5
47	R:R:D46	R:R:L42	8.14	Yes	Yes	2	9	7
48	R:R:L42	R:R:T282	4.42	Yes	No	2	7	8
49	R:R:M43	R:R:P44	3.35	Yes	Yes	2	7	6
50	R:R:M43	R:R:V45	4.56	Yes	No	2	7	5
51	R:R:M43	R:R:P281	6.71	Yes	No	2	7	7
52	R:R:F102	R:R:P44	10.11	No	Yes	2	8	6
53	R:R:K106	R:R:P44	3.35	No	Yes	2	9	6
54	R:R:F126	R:R:P44	11.56	No	Yes	2	7	6
55	R:R:P281	R:R:V45	3.53	No	No	2	7	5
56	R:R:D46	R:R:L49	4.07	Yes	Yes	2	9	8
57	R:R:D46	R:R:P281	4.83	Yes	No	2	9	7
58	R:R:D46	R:R:T282	8.67	Yes	No	2	9	8
59	R:R:F126	R:R:M47	11.2	No	No	2	7	5
60	R:R:M47	R:R:P127	3.35	No	No	2	5	7
61	R:R:I48	R:R:L95	4.28	No	Yes	0	9	7
62	R:R:I48	R:R:L98	5.71	No	No	0	9	6
63	R:R:I48	R:R:L99	7.14	No	No	0	9	9
64	R:R:L276	R:R:L49	4.15	No	Yes	0	9	8
65	R:R:L49	R:R:S280	4.5	Yes	No	2	8	9
66	R:R:L95	R:R:S51	7.51	Yes	No	0	7	7
67	R:R:L130	R:R:S51	4.5	No	No	0	8	7
68	R:R:L52	R:R:L95	9.69	No	Yes	0	9	7
69	R:R:I54	R:R:S55	3.1	No	No	0	6	8
70	R:R:L91	R:R:S55	9.01	No	No	0	6	8
71	R:R:R56	R:R:T92	3.88	No	No	0	9	8
72	R:R:I269	R:R:R56	11.27	No	No	0	8	9
73	R:R:H272	R:R:R56	15.8	Yes	No	0	9	9
74	R:R:F57	R:R:W61	5.01	No	No	0	6	3
75	R:R:C58	R:R:F88	15.36	No	No	0	2	4
76	R:R:L59	R:R:W85	21.64	No	Yes	1	5	5
77	R:R:L59	R:R:Y266	5.86	No	Yes	1	5	4
78	R:R:M64	R:R:Q60	4.08	Yes	Yes	1	3	7
79	R:R:Q60	R:R:Y266	10.15	Yes	Yes	1	7	4
80	R:R:M64	R:R:W61	5.82	Yes	No	0	3	3
81	R:R:A62	R:R:W85	3.89	No	Yes	0	4	5
82	R:R:N67	R:R:S63	4.47	Yes	Yes	1	3	5
83	R:R:S63	R:R:W85	3.71	Yes	Yes	1	5	5
84	R:R:S63	R:R:Y266	11.45	Yes	Yes	1	5	4
85	L:L:?1	R:R:S63	3.95	Yes	Yes	1	0	5
86	R:R:L65	R:R:L81	5.54	No	No	0	4	2
87	L:L:?1	R:R:N66	5.42	Yes	No	0	0	5
88	R:R:N67	R:R:W259	3.39	Yes	Yes	1	3	3
89	R:R:E262	R:R:N67	11.83	Yes	Yes	1	3	3
90	R:R:F68	R:R:F72	11.79	No	Yes	1	3	3
91	R:R:F68	R:R:W259	13.03	No	Yes	1	3	3
92	R:R:C69	R:R:S70	3.44	No	No	0	3	3
93	R:R:C69	R:R:C79	7.28	No	No	0	3	3
94	R:R:F72	R:R:Y71	11.35	Yes	No	1	3	2
95	R:R:L258	R:R:Y71	3.52	No	No	1	2	2
96	R:R:W259	R:R:Y71	21.22	Yes	No	1	3	2
97	R:R:F72	R:R:W259	6.01	Yes	Yes	1	3	3
98	R:R:N73	R:R:Y76	6.98	No	No	0	3	2
99	R:R:C79	R:R:Y76	5.38	No	No	0	3	2
100	R:R:N80	R:R:T82	4.39	No	No	0	3	1
101	R:R:L81	R:R:T84	5.9	No	No	0	2	2
102	R:R:I83	R:R:N148	5.66	No	No	0	4	3
103	R:R:F88	R:R:T84	7.78	No	No	0	4	2
104	R:R:N89	R:R:W85	9.04	Yes	Yes	1	8	5
105	R:R:W85	R:R:Y239	3.86	Yes	Yes	1	5	7
106	R:R:I243	R:R:W85	3.52	Yes	Yes	1	3	5
107	R:R:W85	R:R:Y266	7.72	Yes	Yes	1	5	4
108	L:L:?1	R:R:W85	30.71	Yes	Yes	1	0	5
109	R:R:E86	R:R:I90	8.2	Yes	No	0	4	6
110	R:R:E86	R:R:I141	5.47	Yes	No	0	4	5
111	R:R:E86	R:R:H181	4.92	Yes	Yes	1	4	2
112	L:L:?1	R:R:E86	3.49	Yes	Yes	1	0	4
113	R:R:F87	R:R:T137	11.67	No	No	0	7	8
114	R:R:C138	R:R:F87	4.19	No	No	0	3	7
115	R:R:F93	R:R:N89	9.67	Yes	Yes	1	6	8
116	R:R:N89	R:R:Y239	11.63	Yes	Yes	1	8	7
117	R:R:I243	R:R:N89	7.08	Yes	Yes	1	3	8
118	R:R:I90	R:R:T137	6.08	No	No	0	6	8
119	R:R:A184	R:R:I90	3.25	No	No	0	4	6
120	R:R:L134	R:R:L91	4.15	No	No	0	5	6
121	R:R:L91	R:R:T137	8.84	No	No	0	6	8
122	R:R:F93	R:R:L185	4.87	Yes	No	0	6	5
123	R:R:F236	R:R:F93	17.15	Yes	Yes	1	7	6
124	R:R:F93	R:R:Y239	6.19	Yes	Yes	1	6	7
125	R:R:F240	R:R:F93	5.36	Yes	Yes	0	6	6
126	R:R:I136	R:R:W94	8.22	No	No	0	4	9
127	R:R:P188	R:R:W94	32.43	No	No	0	8	9
128	R:R:C133	R:R:L95	3.17	No	Yes	0	8	7
129	R:R:L99	R:R:N96	5.49	No	Yes	0	9	7
130	R:R:F192	R:R:N96	8.46	Yes	Yes	1	8	7
131	R:R:F236	R:R:N96	10.87	Yes	Yes	1	7	7
132	R:R:H272	R:R:N96	10.2	Yes	Yes	1	9	7
133	R:R:L191	R:R:S97	4.5	No	No	0	5	8
134	R:R:F192	R:R:S97	3.96	Yes	No	0	8	8
135	R:R:L99	R:R:Y103	10.55	No	No	0	9	9
136	R:R:F192	R:R:T100	9.08	Yes	No	1	8	8
137	R:R:S195	R:R:T100	4.8	No	No	0	8	8
138	R:R:T100	R:R:T196	6.28	No	Yes	1	8	7
139	R:R:L191	R:R:V101	4.47	No	No	0	5	7
140	R:R:S195	R:R:V101	6.46	No	No	0	8	7
141	R:R:F102	R:R:K106	11.17	No	No	2	8	9
142	R:R:C104	R:R:F198	9.78	No	No	0	8	7
143	R:R:I105	R:R:R119	5.01	No	No	0	7	9
144	R:R:F110	R:R:S108	6.61	Yes	No	0	8	7
145	R:R:F115	R:R:S108	7.93	Yes	No	0	9	7
146	R:R:Q206	R:R:S109	5.78	No	No	0	5	7
147	R:R:F110	R:R:F198	12.86	Yes	No	0	8	7
148	R:R:F110	R:R:S202	7.93	Yes	No	0	8	9
149	R:R:H112	R:R:H113	13.14	No	No	4	7	5
150	R:R:H112	R:R:I114	7.95	No	No	4	7	4
151	R:R:F115	R:R:H112	3.39	Yes	No	0	9	7
152	R:R:H113	R:R:I114	11.93	No	No	4	5	4
153	R:R:F115	R:R:F198	5.36	Yes	No	0	9	7
154	R:R:R121	R:R:W117	28.99	No	No	0	8	6
155	R:R:I122	R:R:L118	4.28	No	No	0	8	8
156	R:R:R124	R:R:W120	6	No	No	0	5	4
157	R:R:I122	R:R:I129	4.42	No	No	0	8	7
158	R:R:L125	R:R:R124	4.86	No	No	0	6	5
159	R:R:L125	R:R:W128	6.83	No	No	0	6	3
160	R:R:F126	R:R:P127	4.33	No	No	2	7	7
161	R:R:I136	R:R:V139	4.61	No	No	0	4	4
162	R:R:I136	R:R:T140	3.04	No	No	0	4	5
163	R:R:I141	R:R:S144	4.64	No	No	0	5	3
164	R:R:I142	R:R:P143	10.16	No	No	0	5	4
165	R:R:I146	R:R:P143	3.39	No	No	0	3	4
166	R:R:H181	R:R:S144	6.97	Yes	No	0	2	3
167	R:R:G147	R:R:Q177	4.93	No	Yes	0	3	1
168	R:R:Q153	R:R:Y149	15.78	No	No	0	3	3
169	R:R:F173	R:R:I150	8.79	No	Yes	0	4	2
170	R:R:H174	R:R:Q151	17.31	No	No	0	3	3
171	R:R:Q151	R:R:Q177	15.36	No	Yes	0	3	1
172	R:R:E171	R:R:Q175	14.02	No	No	0	3	1
173	R:R:E171	R:R:F178	9.33	No	No	0	3	4
174	R:R:F173	R:R:Y176	10.32	No	No	0	4	3
175	R:R:Q179	R:R:V183	5.73	No	No	0	4	5
176	R:R:H181	R:R:I247	3.98	Yes	No	1	2	4
177	L:L:?1	R:R:H181	3.38	Yes	Yes	1	0	2
178	R:R:T182	R:R:V186	3.17	No	No	0	4	3
179	R:R:I247	R:R:T182	3.04	No	No	0	4	4
180	R:R:I243	R:R:L185	4.28	Yes	No	0	3	5
181	R:R:I190	R:R:V186	3.07	No	No	0	4	3
182	R:R:I187	R:R:P188	3.39	No	No	0	5	8
183	R:R:F189	R:R:F192	4.29	No	Yes	0	6	8
184	R:R:F189	R:R:T237	7.78	No	No	0	6	5
185	R:R:F189	R:R:F240	21.43	No	Yes	0	6	6
186	R:R:F192	R:R:T196	7.78	Yes	Yes	1	8	7
187	R:R:F192	R:R:F236	3.22	Yes	Yes	1	8	7
188	R:R:F233	R:R:T196	7.78	Yes	Yes	0	7	7
189	R:R:L199	R:R:L229	4.15	No	No	0	9	7
190	R:R:L226	R:R:M200	5.65	No	Yes	0	7	8
191	R:R:L229	R:R:M200	5.65	No	Yes	0	7	8
192	R:R:I207	R:R:L203	4.28	Yes	No	0	8	9
193	R:R:L203	R:R:L226	15.22	No	No	0	9	7
194	R:R:I207	R:R:T204	3.04	Yes	No	0	8	6
195	R:R:L226	R:R:T204	4.42	No	No	0	7	6
196	R:R:H209	R:R:K205	11.79	No	No	0	5	5
197	R:R:Q206	R:R:R222	14.02	No	No	0	5	9
198	R:R:F223	R:R:I207	5.02	No	Yes	0	6	8
199	R:R:H210	R:R:R222	10.16	No	No	0	6	9
200	R:R:C215	R:R:S218	6.89	No	No	0	6	8
201	R:R:F223	R:R:M219	7.46	No	No	0	6	7
202	R:R:S228	R:R:V231	3.23	No	No	0	7	7
203	R:R:S275	R:R:V231	3.23	No	No	0	7	7
204	R:R:L232	R:R:S275	4.5	No	No	0	8	7
205	R:R:F233	R:R:T237	7.78	Yes	No	0	7	5
206	R:R:M271	R:R:V235	16.74	No	No	0	4	7
207	R:R:F236	R:R:Y239	4.13	Yes	Yes	1	7	7
208	R:R:F236	R:R:H272	10.18	Yes	Yes	1	7	9
209	R:R:F268	R:R:S238	11.89	No	No	0	5	6
210	R:R:T242	R:R:Y239	4.99	No	Yes	1	6	7
211	R:R:I243	R:R:Y239	13.3	Yes	Yes	1	3	7
212	R:R:V265	R:R:Y239	3.79	No	Yes	1	4	7
213	R:R:I269	R:R:Y239	10.88	No	Yes	0	8	7
214	R:R:F240	R:R:L241	7.31	Yes	No	0	6	4
215	R:R:F240	R:R:L244	18.27	Yes	No	0	6	4
216	R:R:I243	R:R:T242	4.56	Yes	No	1	3	6
217	R:R:T242	R:R:V265	7.93	No	No	1	6	4
218	R:R:I245	R:R:W261	4.7	No	Yes	0	5	4
219	L:L:?1	R:R:T246	6.79	Yes	No	0	0	4
220	L:L:?1	R:R:I247	3.76	Yes	No	1	0	4
221	R:R:G249	R:R:I248	3.53	No	No	0	5	4
222	R:R:L251	R:R:T250	5.9	No	No	0	1	3
223	R:R:F252	R:R:K254	3.72	No	Yes	1	2	3
224	R:R:F252	R:R:W257	25.05	No	Yes	0	2	3
225	R:R:F252	R:R:W261	37.08	No	Yes	1	2	4
226	R:R:D253	R:R:R255	3.57	No	No	0	1	5
227	R:R:C256	R:R:D253	12.45	No	No	0	1	1
228	R:R:K254	R:R:L258	4.23	Yes	No	1	3	2
229	R:R:K254	R:R:W261	9.28	Yes	Yes	1	3	4
230	R:R:E262	R:R:K254	5.4	Yes	Yes	1	3	3
231	L:L:?1	R:R:K254	7.42	Yes	Yes	1	0	3
232	R:R:V260	R:R:W257	14.71	No	Yes	0	4	3
233	R:R:L258	R:R:W259	18.22	No	Yes	1	2	3
234	R:R:F264	R:R:W261	9.02	No	Yes	0	4	4
235	R:R:E262	R:R:Y266	4.49	Yes	Yes	1	3	4
236	L:L:?1	R:R:E262	6.97	Yes	Yes	1	0	3
237	R:R:F264	R:R:F268	9.65	No	No	0	4	5
238	R:R:V265	R:R:Y266	5.05	No	Yes	1	4	4
239	R:R:I269	R:R:Y266	3.63	No	Yes	0	8	4
240	R:R:H272	R:R:L276	6.43	Yes	No	0	9	9
241	R:R:L283	R:R:S280	6.01	No	No	0	9	9
242	R:R:M200	R:R:T196	3.01	Yes	Yes	0	8	7
243	R:R:L19	R:R:V15	2.98	No	No	0	6	4
244	R:R:L283	R:R:V31	2.98	No	No	0	9	8
245	R:R:L270	R:R:T20	2.95	Yes	No	0	7	5
246	L:L:?1	R:R:T82	2.91	Yes	No	0	0	1
247	R:R:F93	R:R:P188	2.89	Yes	No	0	6	8
248	R:R:I12	R:R:L16	2.85	No	No	0	5	5
249	R:R:I129	R:R:L98	2.85	No	No	0	7	6
250	R:R:I150	R:R:L154	2.85	Yes	No	0	2	2
251	R:R:I197	R:R:L193	2.85	No	No	0	5	6
252	R:R:L27	R:R:M277	2.83	No	No	0	8	9
253	R:R:L278	R:R:M277	2.83	No	No	0	6	9
254	R:R:K106	R:R:L123	2.82	No	No	0	9	7
255	R:R:L131	R:R:L134	2.77	No	No	0	5	5
256	R:R:L229	R:R:L232	2.77	No	No	0	7	8
257	R:R:I150	R:R:Q151	2.74	Yes	No	0	2	3
258	R:R:I152	R:R:Q153	2.74	No	No	0	2	3
259	R:R:P127	R:R:W128	2.7	No	No	0	7	3
260	R:R:E17	R:R:L270	2.65	No	Yes	0	8	7
261	R:R:F110	R:R:S109	2.64	Yes	No	0	8	7
262	R:R:R227	R:R:S228	2.64	No	No	0	7	7
263	R:R:R41	R:R:V39	2.62	No	No	0	5	5
264	R:R:C256	R:R:W257	2.61	No	Yes	0	1	3
265	R:R:F115	R:R:I105	2.51	Yes	No	0	9	7
266	R:R:F233	R:R:I197	2.51	Yes	No	0	7	5
267	R:R:I207	R:R:R222	2.51	Yes	No	0	8	9
268	R:R:F233	R:R:I234	2.51	Yes	No	0	7	5
269	R:R:F268	R:R:M271	2.49	No	No	0	5	4
270	R:R:H181	R:R:Q177	2.47	Yes	Yes	0	2	1
271	R:R:L116	R:R:R119	2.43	No	No	0	6	9
272	R:R:F178	R:R:H174	2.26	No	No	0	4	3
273	R:R:G53	R:R:S25	1.86	No	No	0	8	9
274	R:R:G249	R:R:T250	1.82	No	No	0	5	3
275	R:R:G147	R:R:I146	1.76	No	No	0	3	3
276	R:R:G132	R:R:M135	1.75	No	No	0	5	5
277	R:R:G132	R:R:L131	1.71	No	No	0	5	5
278	R:R:A62	R:R:T84	1.68	No	No	0	4	2
279	R:R:N216	R:R:P217	1.63	No	No	0	8	5
280	R:R:A145	R:R:I83	1.62	No	No	0	4	4
281	R:R:A230	R:R:M200	1.61	No	Yes	0	5	8
282	R:R:V183	R:R:V186	1.6	No	No	0	5	3
283	R:R:G213	R:R:H214	1.59	No	No	0	7	5
284	R:R:A225	R:R:L203	1.58	No	No	0	9	9
285	R:R:I22	R:R:S26	1.55	No	No	0	7	8
286	R:R:I54	R:R:V29	1.54	No	No	0	6	6
287	R:R:M11	R:R:V8	1.52	Yes	No	0	4	4
288	R:R:M11	R:R:V15	1.52	Yes	No	0	4	4
289	R:R:A180	R:R:Q179	1.52	No	No	0	3	4
290	R:R:L155	R:R:T156	1.47	No	No	0	3	1
291	R:R:C215	R:R:H210	1.47	No	No	0	6	6
292	R:R:I245	R:R:L251	1.43	No	No	0	5	1
293	R:R:Q153	R:R:T156	1.42	No	No	0	3	1
294	R:R:M219	R:R:N216	1.4	No	No	0	7	8
295	R:R:A263	R:R:F10	1.39	No	No	0	5	5
296	R:R:I207	R:R:Q208	1.37	Yes	No	0	8	6
297	R:R:N148	R:R:Q177	1.32	No	Yes	0	3	1
298	R:R:S279	R:R:Y103	1.27	No	No	0	7	9
299	R:R:M43	R:R:R285	1.24	Yes	No	0	7	6
300	R:R:I150	R:R:Y149	1.21	Yes	No	0	2	3
301	R:R:H209	R:R:H210	1.19	No	No	0	5	6
302	R:R:L118	R:R:W117	1.14	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I2	5.0275	4	3	6
2	R:R:M11	8.262	5	1	4
3	R:R:Y14	8.62571	7	1	4
4	R:R:I28	4.7225	4	2	9
5	R:R:L32	5.25	4	2	8
6	R:R:W36	7.48	4	0	6
7	R:R:L42	6.034	5	2	7
8	R:R:M43	3.965	4	2	7
9	R:R:P44	7.0925	4	2	6
10	R:R:D46	6.228	5	2	9
11	R:R:L49	4.965	4	2	8
12	R:R:Q60	5.90333	6	1	7
13	R:R:S63	5.48	5	1	5
14	R:R:M64	5.8025	4	1	3
15	R:R:N67	6.375	4	1	3
16	R:R:F72	9.775	4	1	3
17	R:R:W85	10.5112	8	1	5
18	R:R:E86	5.52	4	1	4
19	R:R:N89	9.355	4	1	8
20	R:R:F93	7.68833	6	1	6
21	R:R:L95	6.1625	4	0	7
22	R:R:N96	8.755	4	1	7
23	R:R:F110	7.51	4	0	8
24	R:R:F115	4.7975	4	0	9
25	R:R:I150	3.8975	4	0	2
26	R:R:Q177	6.02	4	0	1
27	R:R:H181	4.344	5	1	2
28	R:R:F192	6.13167	6	1	8
29	R:R:T196	6.2125	4	1	7
30	R:R:M200	3.98	4	0	8
31	R:R:I207	3.244	5	0	8
32	R:R:F233	5.145	4	0	7
33	R:R:F236	9.11	5	1	7
34	R:R:Y239	7.34625	8	1	7
35	R:R:F240	13.0925	4	0	6
36	R:R:I243	6.548	5	1	3
37	R:R:K254	6.01	5	1	3
38	R:R:W257	12.9425	4	0	3
39	R:R:W259	13.995	6	1	3
40	R:R:W261	15.02	4	1	4
41	R:R:E262	9.554	5	1	3
42	R:R:Y266	7.905	8	1	4
43	R:R:L270	3.4675	4	0	7
44	R:R:H272	10.6525	4	1	9
45	L:L:?1	7.48	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E17	R:R:L270	11.6235	2.65	No	Yes	0	8	7
2	R:R:I21	R:R:L270	25.9935	4.28	No	Yes	0	8	7
3	R:R:I21	R:R:Q60	28.8457	6.86	No	Yes	0	8	7
4	R:R:F252	R:R:K254	15.9145	3.72	No	Yes	1	2	3
5	R:R:F252	R:R:W257	15.2005	25.05	No	Yes	0	2	3
6	R:R:Q60	R:R:Y266	46.749	10.15	Yes	Yes	1	7	4
7	R:R:E262	R:R:Y266	12.6325	4.49	Yes	Yes	1	3	4
8	R:R:I22	R:R:Q60	12.5851	5.49	No	Yes	0	7	7
9	R:R:M64	R:R:Y14	13.3574	7.18	Yes	Yes	1	3	4
10	R:R:M64	R:R:W61	17.6775	5.82	Yes	No	0	3	3
11	R:R:F57	R:R:W61	18.3987	5.01	No	No	0	6	3
12	R:R:F57	R:R:S25	12.2719	3.96	No	No	0	6	9
13	R:R:I269	R:R:Y266	32.4591	3.63	No	Yes	0	8	4
14	R:R:I269	R:R:R56	18.06	11.27	No	No	0	8	9
15	R:R:H272	R:R:R56	17.5646	15.8	Yes	No	0	9	9
16	R:R:H272	R:R:L276	61.8767	6.43	Yes	No	0	9	9
17	R:R:L276	R:R:L49	60.5398	4.15	No	Yes	0	9	8
18	L:L:?1	R:R:K254	25.0792	7.42	Yes	Yes	1	0	3
19	L:L:?1	R:R:W85	58.1357	30.71	Yes	Yes	1	0	5
20	R:R:W85	R:R:Y239	76.407	3.86	Yes	Yes	1	5	7
21	R:R:F236	R:R:Y239	97.5267	4.13	Yes	Yes	1	7	7
22	R:R:F236	R:R:H272	32.8817	10.18	Yes	Yes	1	7	9
23	R:R:D46	R:R:L49	46.3192	4.07	Yes	Yes	2	9	8
24	R:R:D46	R:R:L42	12.4977	8.14	Yes	Yes	2	9	7
25	R:R:D46	R:R:P281	23.4401	4.83	Yes	No	2	9	7
26	R:R:M43	R:R:P281	20.3038	6.71	Yes	No	2	7	7
27	R:R:M43	R:R:P44	17.2185	3.35	Yes	Yes	2	7	6
28	R:R:F126	R:R:P44	11.2046	11.56	No	Yes	2	7	6
29	R:R:F236	R:R:N96	12.5924	10.87	Yes	Yes	1	7	7
30	R:R:L99	R:R:N96	21.2545	5.49	No	Yes	0	9	7
31	R:R:I48	R:R:L99	17.091	7.14	No	No	0	9	9
32	L:L:?1	R:R:E86	19.2766	3.49	Yes	Yes	1	0	4
33	R:R:E86	R:R:I90	18.3696	8.2	Yes	No	0	4	6
34	R:R:I90	R:R:T137	15.6231	6.08	No	No	0	6	8
35	R:R:L91	R:R:T137	11.4487	8.84	No	No	0	6	8
36	R:R:F93	R:R:P188	11.1427	2.89	Yes	No	0	6	8
37	R:R:F192	R:R:F236	87.8556	3.22	Yes	Yes	1	8	7
38	R:R:F192	R:R:T196	100	7.78	Yes	Yes	1	8	7
39	R:R:F110	R:R:F198	23.4218	12.86	Yes	No	0	8	7
40	R:R:F110	R:R:S109	49.3243	2.64	Yes	No	0	8	7
41	R:R:Q206	R:R:S109	51.6046	5.78	No	No	0	5	7
42	R:R:Q206	R:R:R222	54.1216	14.02	No	No	0	5	9
43	R:R:I207	R:R:R222	68.8158	2.51	Yes	No	0	8	9
44	R:R:I207	R:R:L203	41.8133	4.28	Yes	No	0	8	9
45	R:R:L203	R:R:L226	44.1045	15.22	No	No	0	9	7
46	R:R:L226	R:R:M200	87.8556	5.65	No	Yes	0	7	8
47	R:R:M200	R:R:T196	96.6561	3.01	Yes	Yes	0	8	7
48	R:R:I207	R:R:T204	41.7004	3.04	Yes	No	0	8	6
49	R:R:L226	R:R:T204	42.8405	4.42	No	No	0	7	6
50	R:R:F115	R:R:I105	15.6886	2.51	Yes	No	0	9	7
51	R:R:F115	R:R:S108	18.253	7.93	Yes	No	0	9	7
52	R:R:F110	R:R:S108	20.8393	6.61	Yes	No	0	8	7
53	R:R:F115	R:R:F198	18.2749	5.36	Yes	No	0	9	7
54	R:R:I105	R:R:R119	10.4688	5.01	No	No	0	7	9
55	R:R:F115	R:R:H112	15.6996	3.39	Yes	No	0	9	7
56	R:R:H181	R:R:Q177	29.3702	2.47	Yes	Yes	0	2	1
57	L:L:?1	R:R:H181	29.6907	3.38	Yes	Yes	1	0	2
58	R:R:Q151	R:R:Q177	19.2365	15.36	No	Yes	0	3	1
59	R:R:I150	R:R:Q151	12.6106	2.74	Yes	No	0	2	3
60	R:R:L229	R:R:M200	10.4397	5.65	No	Yes	0	7	8
61	R:R:H210	R:R:R222	13.2299	10.16	No	No	0	6	9
62	R:R:F223	R:R:I207	10.589	5.02	No	Yes	0	6	8
63	R:R:V265	R:R:Y266	15.5174	5.05	No	Yes	1	4	4
64	R:R:N67	R:R:W259	13.2845	3.39	Yes	Yes	1	3	3
65	R:R:W85	R:R:Y266	20.2054	7.72	Yes	Yes	1	5	4
66	R:R:V265	R:R:Y239	15.124	3.79	No	Yes	1	4	7
67	R:R:I269	R:R:Y239	15.4846	10.88	No	Yes	0	8	7
68	R:R:H272	R:R:N96	19.6736	10.2	Yes	Yes	1	9	7
69	R:R:K254	R:R:W261	13.4849	9.28	Yes	Yes	1	3	4
70	R:R:Y14	R:R:Y266	13.1534	14.89	Yes	Yes	1	4	4
71	R:R:S63	R:R:W85	10.6181	3.71	Yes	Yes	1	5	5
72	R:R:F192	R:R:N96	20.7154	8.46	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S63	R:R:Y14	3.82	1	Yes	Yes	5	4	1	2
R:R:N67	R:R:Y14	5.81	1	Yes	Yes	3	4	2	2
R:R:E262	R:R:Y14	19.08	1	Yes	Yes	3	4	1	2
R:R:Y14	R:R:Y266	14.89	1	Yes	Yes	4	4	2	2
R:R:L59	R:R:W85	21.64	1	No	Yes	5	5	2	1
R:R:L59	R:R:Y266	5.86	1	No	Yes	5	4	2	2
R:R:A62	R:R:W85	3.89	0	No	Yes	4	5	2	1
R:R:N67	R:R:S63	4.47	1	Yes	Yes	3	5	2	1
R:R:S63	R:R:W85	3.71	1	Yes	Yes	5	5	1	1
R:R:S63	R:R:Y266	11.45	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:S63	3.95	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N66	5.42	1	Yes	No	0	5	0	1
R:R:E262	R:R:N67	11.83	1	Yes	Yes	3	3	1	2
R:R:N80	R:R:T82	4.39	0	No	No	3	1	2	1
R:R:N89	R:R:W85	9.04	1	Yes	Yes	8	5	2	1
R:R:W85	R:R:Y239	3.86	1	Yes	Yes	5	7	1	2
R:R:I243	R:R:W85	3.52	1	Yes	Yes	3	5	2	1
R:R:W85	R:R:Y266	7.72	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:W85	30.71	1	Yes	Yes	0	5	0	1
R:R:E86	R:R:I90	8.2	1	Yes	No	4	6	1	2
R:R:E86	R:R:I141	5.47	1	Yes	No	4	5	1	2
R:R:E86	R:R:H181	4.92	1	Yes	Yes	4	2	1	1
L:L:?1	R:R:E86	3.49	1	Yes	Yes	0	4	0	1
R:R:N89	R:R:Y239	11.63	1	Yes	Yes	8	7	2	2
R:R:I243	R:R:N89	7.08	1	Yes	Yes	3	8	2	2
R:R:I141	R:R:S144	4.64	0	No	No	5	3	2	2
R:R:H181	R:R:S144	6.97	1	Yes	No	2	3	1	2
R:R:H181	R:R:I247	3.98	1	Yes	No	2	4	1	1
L:L:?1	R:R:H181	3.38	1	Yes	Yes	0	2	0	1
R:R:I247	R:R:T182	3.04	1	No	No	4	4	1	2
R:R:I243	R:R:Y239	13.3	1	Yes	Yes	3	7	2	2
L:L:?1	R:R:T246	6.79	1	Yes	No	0	4	0	1
L:L:?1	R:R:I247	3.76	1	Yes	No	0	4	0	1
R:R:F252	R:R:K254	3.72	1	No	Yes	2	3	2	1
R:R:F252	R:R:W261	37.08	1	No	Yes	2	4	2	2
R:R:K254	R:R:L258	4.23	1	Yes	No	3	2	1	2
R:R:K254	R:R:W261	9.28	1	Yes	Yes	3	4	1	2
R:R:E262	R:R:K254	5.4	1	Yes	Yes	3	3	1	1
L:L:?1	R:R:K254	7.42	1	Yes	Yes	0	3	0	1
R:R:E262	R:R:Y266	4.49	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:E262	6.97	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:T82	2.91	1	Yes	No	0	1	0	1
R:R:H181	R:R:Q177	2.47	1	Yes	Yes	2	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KPD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	251
Number of Links	302
Number of Hubs	45
Number of Links mediated by Hubs	163
Number of Communities	4
Number of Nodes involved in Communities	58
Number of Links involved in Communities	97

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	64487
Length Of Smallest Path	3
Average Path Length	13.2515
Length of Longest Path	29
Minimum Path Strength	1.33
Average Path Strength	6.86789
Maximum Path Strength	31.065
Minimum Path Correlation	0.7
Average Path Correlation	0.93082
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	46.1071
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.5561
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • taste receptor activity • molecular transducer activity • bitter taste receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • system process • nervous system process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • response to chemical • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cell surface • external side of plasma membrane • endoplasmic reticulum • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SA0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SA0
Name	Salicin
Synonyms	D-(-)-salicin
Identifier
Formula	C13 H18 O7
Molecular Weight	286.278
SMILES
PubChem	439503
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	5
Total Bonds	39
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV7
Sequence	>9KPD_nogp_Chain_R I P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R R L M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N L N Y V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S S F T H H I F L W L R W R I L R L F P W I L L G L M I T C V T I I P S A I G N Y I Q I Q L L T E N F H Q Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H C N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F D K R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K R C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K6L	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-	Gi2/β1/γ2	2.77	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9K6L (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-		2.77	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPD	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-	chim(Gs-CtGt3)/β1/γ2	2.84	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPD (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-		2.84	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPE	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-	Gi1/β1/γ2	3.35	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPE (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-		3.35	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPF	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-	Gi1/β1/γ2	3.15	2025-04-02	doi.org/10.1016/j.celrep.2025.115604
	9KPF (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	Salicin	-		3.15	2025-04-02	doi.org/10.1016/j.celrep.2025.115604

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