psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I2	R:R:P3	6.77	No	No	0	6	6
2	R:R:I2	R:R:W257	3.52	No	No	0	6	3
3	R:R:P3	R:R:Q5	7.9	No	No	0	6	6
4	R:R:I4	R:R:T7	3.04	No	No	0	4	4
5	R:R:F10	R:R:L6	6.09	Yes	No	3	5	5
6	R:R:L6	R:R:V260	2.98	No	No	3	5	4
7	R:R:T7	R:R:V8	3.17	No	No	0	4	4
8	R:R:F10	R:R:F9	8.57	Yes	No	0	5	5
9	R:R:F9	R:R:I13	11.3	No	No	0	5	7
10	R:R:F10	R:R:V260	13.11	Yes	No	3	5	4
11	R:R:A263	R:R:F10	2.77	No	Yes	0	5	5
12	R:R:M11	R:R:W259	17.45	No	No	0	4	3
13	R:R:E17	R:R:I13	4.1	No	No	0	8	7
14	R:R:Q60	R:R:Y14	3.38	Yes	Yes	1	7	4
15	R:R:S63	R:R:Y14	2.54	Yes	Yes	1	5	4
16	R:R:N67	R:R:Y14	10.47	Yes	Yes	1	3	4
17	R:R:E262	R:R:Y14	15.71	Yes	Yes	1	3	4
18	R:R:Y14	R:R:Y266	12.91	Yes	Yes	1	4	4
19	R:R:A267	R:R:E17	4.53	No	No	0	6	8
20	R:R:Q60	R:R:S18	4.33	Yes	No	1	7	6
21	R:R:M64	R:R:S18	4.6	No	No	1	3	6
22	R:R:L19	R:R:T20	2.95	No	No	0	6	5
23	R:R:I21	R:R:Q60	6.86	No	Yes	0	8	7
24	R:R:I21	R:R:S273	3.1	No	No	0	8	9
25	R:R:I22	R:R:Q60	5.49	No	Yes	0	7	7
26	R:R:I22	R:R:W61	8.22	No	No	0	7	3
27	R:R:Q24	R:R:T274	2.83	No	No	0	7	4
28	R:R:M277	R:R:Q24	12.23	Yes	No	0	9	7
29	R:R:F57	R:R:S25	2.64	No	No	0	6	9
30	R:R:L27	R:R:M277	2.83	No	Yes	0	8	9
31	R:R:I28	R:R:L32	2.85	No	No	0	9	8
32	R:R:I28	R:R:L49	2.85	No	No	0	9	8
33	R:R:I28	R:R:M277	2.92	No	Yes	0	9	9
34	R:R:L283	R:R:V31	4.47	Yes	No	0	9	8
35	R:R:D46	R:R:L32	6.79	Yes	No	0	9	8
36	R:R:Q38	R:R:R34	3.5	No	No	0	6	4
37	R:R:E35	R:R:V39	4.28	Yes	No	0	7	5
38	R:R:E35	R:R:L42	2.65	Yes	No	0	7	7
39	R:R:E35	R:R:R285	8.14	Yes	No	2	7	6
40	R:R:E35	R:R:I286	4.1	Yes	No	2	7	5
41	R:R:L42	R:R:W36	10.25	No	Yes	0	7	6
42	R:R:M43	R:R:R41	6.2	No	No	0	7	5
43	R:R:D46	R:R:L42	8.14	Yes	No	0	9	7
44	R:R:D46	R:R:M43	8.32	Yes	No	2	9	7
45	R:R:M43	R:R:T282	3.01	No	Yes	2	7	8
46	R:R:F102	R:R:P44	8.67	Yes	No	0	8	6
47	R:R:F126	R:R:P44	13	Yes	No	0	7	6
48	R:R:D46	R:R:V45	2.92	Yes	Yes	2	9	5
49	R:R:F102	R:R:V45	5.24	Yes	Yes	0	8	5
50	R:R:V45	R:R:Y103	3.79	Yes	No	0	5	9
51	R:R:P281	R:R:V45	3.53	Yes	Yes	2	7	5
52	R:R:D46	R:R:P281	3.22	Yes	Yes	2	9	7
53	R:R:D46	R:R:T282	10.12	Yes	Yes	2	9	8
54	R:R:M47	R:R:P127	3.35	No	No	0	5	7
55	R:R:I48	R:R:L98	5.71	Yes	No	4	9	6
56	R:R:I48	R:R:L99	11.42	Yes	No	0	9	9
57	R:R:F102	R:R:I48	2.51	Yes	Yes	0	8	9
58	R:R:F126	R:R:I48	6.28	Yes	Yes	4	7	9
59	R:R:L276	R:R:L49	4.15	No	No	0	9	8
60	R:R:L49	R:R:S280	3	No	No	0	8	9
61	R:R:L95	R:R:S51	6.01	No	No	0	7	7
62	R:R:L130	R:R:S51	3	No	No	0	8	7
63	R:R:L52	R:R:R56	12.15	No	Yes	0	9	9
64	R:R:L52	R:R:T92	2.95	No	No	0	9	8
65	R:R:L91	R:R:S55	4.5	No	No	0	6	8
66	R:R:S55	R:R:T92	3.2	No	No	0	8	8
67	R:R:L95	R:R:S55	3	No	No	0	7	8
68	R:R:I269	R:R:R56	6.26	No	Yes	0	8	9
69	R:R:H272	R:R:R56	3.39	Yes	Yes	0	9	9
70	R:R:R56	R:R:S273	2.64	Yes	No	0	9	9
71	R:R:F57	R:R:W61	6.01	No	No	0	6	3
72	R:R:C58	R:R:F88	12.57	No	No	0	2	4
73	R:R:L59	R:R:W85	6.83	No	Yes	0	5	5
74	R:R:M64	R:R:Q60	2.72	No	Yes	1	3	7
75	R:R:Q60	R:R:Y266	6.76	Yes	Yes	1	7	4
76	R:R:N67	R:R:S63	5.96	Yes	Yes	1	3	5
77	R:R:S63	R:R:W85	4.94	Yes	Yes	1	5	5
78	R:R:S63	R:R:Y266	8.9	Yes	Yes	1	5	4
79	L:L:?1	R:R:S63	4.94	Yes	Yes	1	0	5
80	R:R:L65	R:R:N66	2.75	No	No	1	4	5
81	R:R:L65	R:R:L81	5.54	No	No	1	4	2
82	R:R:L81	R:R:N66	5.49	No	No	1	2	5
83	L:L:?1	R:R:N66	2.71	Yes	No	1	0	5
84	R:R:E262	R:R:N67	11.83	Yes	Yes	1	3	3
85	L:L:?1	R:R:N67	2.71	Yes	Yes	1	0	3
86	R:R:C69	R:R:C79	7.28	No	No	0	3	3
87	R:R:W259	R:R:Y71	20.26	No	No	0	3	2
88	R:R:F72	R:R:L74	9.74	No	No	0	3	4
89	R:R:N73	R:R:Y76	4.65	No	No	0	3	2
90	R:R:N75	R:R:V77	4.43	No	No	0	2	3
91	R:R:N80	R:R:Y76	8.14	No	No	0	3	2
92	R:R:L78	R:R:V77	2.98	No	No	0	1	3
93	R:R:C79	R:R:V77	5.12	No	No	0	3	3
94	R:R:L81	R:R:T84	4.42	No	No	0	2	2
95	L:L:?1	R:R:T82	2.91	Yes	No	0	0	1
96	R:R:F88	R:R:T84	5.19	No	No	0	4	2
97	R:R:N89	R:R:W85	7.91	Yes	Yes	1	8	5
98	R:R:I243	R:R:W85	5.87	No	Yes	0	3	5
99	L:L:?1	R:R:W85	21.72	Yes	Yes	1	0	5
100	R:R:E86	R:R:I90	2.73	Yes	No	0	4	6
101	R:R:E86	R:R:I141	2.73	Yes	No	0	4	5
102	R:R:E86	R:R:H181	14.77	Yes	No	1	4	2
103	L:L:?1	R:R:E86	5.23	Yes	Yes	1	0	4
104	R:R:F87	R:R:T137	3.89	No	No	0	7	8
105	R:R:F87	R:R:I141	7.54	No	No	0	7	5
106	R:R:N89	R:R:T92	2.92	Yes	No	0	8	8
107	R:R:F93	R:R:N89	6.04	Yes	Yes	1	6	8
108	R:R:L185	R:R:N89	2.75	No	Yes	1	5	8
109	R:R:N89	R:R:Y239	5.81	Yes	No	0	8	7
110	R:R:I90	R:R:T137	6.08	No	No	0	6	8
111	R:R:L134	R:R:L91	2.77	No	No	0	5	6
112	R:R:L91	R:R:T137	5.9	No	No	0	6	8
113	R:R:F93	R:R:L185	7.31	Yes	No	1	6	5
114	R:R:F93	R:R:P188	5.78	Yes	Yes	1	6	8
115	R:R:F236	R:R:F93	9.65	Yes	Yes	1	7	6
116	R:R:F240	R:R:F93	4.29	No	Yes	0	6	6
117	R:R:I187	R:R:W94	3.52	No	No	1	5	9
118	R:R:P188	R:R:W94	14.86	Yes	No	1	8	9
119	R:R:N96	R:R:T100	2.92	No	Yes	1	7	8
120	R:R:F192	R:R:N96	12.08	Yes	No	1	8	7
121	R:R:F236	R:R:N96	12.08	Yes	No	1	7	7
122	R:R:P188	R:R:S97	3.56	Yes	No	0	8	8
123	R:R:L191	R:R:S97	3	No	No	0	5	8
124	R:R:F192	R:R:S97	3.96	Yes	No	0	8	8
125	R:R:F126	R:R:L98	3.65	Yes	No	4	7	6
126	R:R:L99	R:R:Y103	7.03	No	No	0	9	9
127	R:R:F192	R:R:T100	7.78	Yes	Yes	1	8	8
128	R:R:S195	R:R:T100	3.2	No	Yes	0	8	8
129	R:R:T100	R:R:T196	6.28	Yes	Yes	1	8	7
130	R:R:S195	R:R:V101	3.23	No	No	0	8	7
131	R:R:F102	R:R:K106	8.69	Yes	No	0	8	9
132	R:R:C104	R:R:F198	4.19	No	No	0	8	7
133	R:R:F115	R:R:I105	5.02	No	No	0	9	7
134	R:R:I105	R:R:R119	5.01	No	No	0	7	9
135	R:R:K106	R:R:R119	2.48	No	No	0	9	9
136	R:R:F110	R:R:S108	5.28	No	No	0	8	7
137	R:R:F115	R:R:S108	3.96	No	No	0	9	7
138	R:R:H112	R:R:H113	17.91	No	No	5	7	5
139	R:R:H112	R:R:I114	7.95	No	No	5	7	4
140	R:R:F115	R:R:H112	3.39	No	No	0	9	7
141	R:R:H113	R:R:I114	7.95	No	No	5	5	4
142	R:R:I114	R:R:W117	4.7	No	No	0	4	6
143	R:R:R121	R:R:W117	7	No	No	0	8	6
144	R:R:I122	R:R:L118	5.71	No	No	0	8	8
145	R:R:L123	R:R:R119	3.64	No	No	0	7	9
146	R:R:R124	R:R:W120	6	No	No	0	5	4
147	R:R:L125	R:R:R121	4.86	No	No	0	6	8
148	R:R:F126	R:R:I122	2.51	Yes	No	0	7	8
149	R:R:L125	R:R:W128	10.25	No	No	0	6	3
150	R:R:G132	R:R:M135	3.49	No	No	0	5	5
151	R:R:C138	R:R:V139	3.42	No	No	0	3	4
152	R:R:I141	R:R:S144	3.1	No	No	0	5	3
153	R:R:I142	R:R:P143	3.39	No	No	0	5	4
154	R:R:H181	R:R:S144	6.97	No	No	0	2	3
155	R:R:G147	R:R:Q177	4.93	No	No	0	3	1
156	R:R:N148	R:R:Q151	2.64	No	Yes	6	3	3
157	R:R:I152	R:R:N148	4.25	No	No	6	2	3
158	R:R:Q153	R:R:Y149	7.89	No	No	0	3	3
159	R:R:I150	R:R:L154	2.85	No	No	7	2	2
160	R:R:F173	R:R:I150	5.02	No	No	7	4	2
161	R:R:I152	R:R:Q151	8.23	No	Yes	6	2	3
162	R:R:L155	R:R:Q151	2.66	No	Yes	0	3	3
163	R:R:H174	R:R:Q151	3.71	No	Yes	0	3	3
164	R:R:Q151	R:R:Q177	3.84	Yes	No	0	3	1
165	R:R:Q153	R:R:T156	2.83	No	No	0	3	1
166	R:R:F173	R:R:L154	4.87	No	No	7	4	2
167	R:R:E171	R:R:N172	9.2	No	No	0	3	4
168	R:R:E171	R:R:H174	8.62	No	No	0	3	3
169	R:R:F178	R:R:T182	3.89	No	No	0	4	4
170	R:R:F178	R:R:I247	2.51	No	No	0	4	4
171	L:L:?1	R:R:H181	4.23	Yes	No	1	0	2
172	R:R:I187	R:R:P188	5.08	No	Yes	1	5	8
173	R:R:F189	R:R:F236	4.29	No	Yes	0	6	7
174	R:R:F189	R:R:F240	9.65	No	No	0	6	6
175	R:R:L191	R:R:S195	3	No	No	0	5	8
176	R:R:F192	R:R:T196	3.89	Yes	Yes	1	8	7
177	R:R:F192	R:R:F236	7.5	Yes	Yes	1	8	7
178	R:R:F233	R:R:L193	3.65	No	No	0	7	6
179	R:R:F233	R:R:T196	6.49	No	Yes	0	7	7
180	R:R:L199	R:R:L229	5.54	No	No	0	9	7
181	R:R:L226	R:R:M200	4.24	No	Yes	0	7	8
182	R:R:L229	R:R:M200	5.65	No	Yes	0	7	8
183	R:R:L203	R:R:S202	4.5	Yes	No	0	9	9
184	R:R:L203	R:R:R222	7.29	Yes	Yes	0	9	9
185	R:R:L203	R:R:L226	2.77	Yes	No	0	9	7
186	R:R:L226	R:R:T204	2.95	No	No	0	7	6
187	R:R:H209	R:R:K205	13.1	No	No	0	5	5
188	R:R:H210	R:R:Q206	8.65	No	No	8	6	5
189	R:R:Q206	R:R:R222	11.68	No	Yes	8	5	9
190	R:R:I207	R:R:M219	4.37	No	No	0	8	7
191	R:R:I207	R:R:R222	7.52	No	Yes	0	8	9
192	R:R:F223	R:R:I207	6.28	No	No	0	6	8
193	R:R:H209	R:R:Q208	9.89	No	No	0	5	6
194	R:R:H210	R:R:R222	3.39	No	Yes	8	6	9
195	R:R:G213	R:R:H214	3.18	No	No	0	7	5
196	R:R:C215	R:R:M219	3.24	No	No	0	6	7
197	R:R:N216	R:R:P217	3.26	No	No	0	8	5
198	R:R:P217	R:R:S218	3.56	No	No	0	5	8
199	R:R:R227	R:R:T224	2.59	No	No	0	7	5
200	R:R:H272	R:R:L232	6.43	Yes	No	0	9	8
201	R:R:F233	R:R:T237	5.19	No	No	0	7	5
202	R:R:H272	R:R:V235	6.92	Yes	No	0	9	7
203	R:R:F236	R:R:H272	7.92	Yes	Yes	0	7	9
204	R:R:F268	R:R:S238	17.18	No	No	0	5	6
205	R:R:I243	R:R:Y239	10.88	No	No	0	3	7
206	R:R:V265	R:R:Y239	2.52	Yes	No	0	4	7
207	R:R:I243	R:R:T242	3.04	No	Yes	0	3	6
208	R:R:F264	R:R:T242	2.59	No	Yes	9	4	6
209	R:R:T242	R:R:V265	7.93	Yes	Yes	0	6	4
210	R:R:F268	R:R:T242	2.59	No	Yes	9	5	6
211	R:R:I248	R:R:L244	2.85	No	No	0	4	4
212	R:R:I245	R:R:W261	5.87	No	Yes	0	5	4
213	R:R:T246	R:R:W261	10.92	No	Yes	1	4	4
214	L:L:?1	R:R:T246	7.76	Yes	No	1	0	4
215	L:L:?1	R:R:I247	5.63	Yes	No	0	0	4
216	R:R:I248	R:R:T250	4.56	No	No	0	4	3
217	R:R:L251	R:R:T250	2.95	No	No	0	1	3
218	R:R:F252	R:R:K254	7.44	No	No	0	2	3
219	R:R:F252	R:R:W261	28.06	No	Yes	0	2	4
220	R:R:C256	R:R:D253	9.34	No	No	0	1	1
221	R:R:K254	R:R:L258	4.23	No	No	0	3	2
222	L:L:?1	R:R:K254	6.49	Yes	No	0	0	3
223	R:R:C256	R:R:W257	3.92	No	No	0	1	3
224	R:R:L258	R:R:W259	10.25	No	No	0	2	3
225	R:R:E262	R:R:L258	2.65	Yes	No	0	3	2
226	R:R:V265	R:R:W261	4.9	Yes	Yes	0	4	4
227	L:L:?1	R:R:W261	3	Yes	Yes	1	0	4
228	R:R:E262	R:R:Y266	3.37	Yes	Yes	1	3	4
229	L:L:?1	R:R:E262	8.72	Yes	Yes	1	0	3
230	R:R:F264	R:R:F268	12.86	No	No	9	4	5
231	R:R:V265	R:R:Y266	5.05	Yes	Yes	0	4	4
232	R:R:I269	R:R:Y266	3.63	No	Yes	0	8	4
233	R:R:H272	R:R:L276	2.57	Yes	No	0	9	9
234	R:R:L278	R:R:T274	2.95	No	No	0	6	4
235	R:R:L283	R:R:M277	2.83	Yes	Yes	0	9	9
236	R:R:P281	R:R:S280	3.56	Yes	No	0	7	9
237	R:R:L283	R:R:S280	3	Yes	No	0	9	9
238	R:R:R285	R:R:T282	5.17	No	Yes	2	6	8
239	R:R:I286	R:R:T282	3.04	No	Yes	2	5	8
240	R:R:L283	R:R:L287	6.92	Yes	No	0	9	6
241	R:R:I286	R:R:R285	7.52	No	No	2	5	6
242	R:R:V260	R:R:W257	2.45	No	No	0	4	3
243	R:R:F240	R:R:L244	2.44	No	No	0	6	4
244	R:R:L125	R:R:R124	2.43	No	No	0	6	5
245	R:R:I150	R:R:Y149	2.42	No	No	0	2	3
246	R:R:D253	R:R:R255	2.38	No	No	0	1	5
247	R:R:I136	R:R:W94	2.35	No	No	0	4	9
248	R:R:E17	R:R:Y266	2.24	No	Yes	0	8	4
249	R:R:F110	R:R:F198	2.14	No	No	0	8	7
250	R:R:F72	R:R:Y71	2.06	No	No	0	3	2
251	R:R:G53	R:R:S25	1.86	No	No	0	8	9
252	R:R:G213	R:R:T212	1.82	No	No	0	7	6
253	R:R:G147	R:R:I146	1.76	No	No	0	3	3
254	R:R:G249	R:R:I248	1.76	No	No	0	5	4
255	R:R:A62	R:R:T84	1.68	No	No	0	4	2
256	R:R:A184	R:R:T140	1.68	No	No	0	4	5
257	R:R:K284	R:R:P281	1.67	No	Yes	0	7	7
258	R:R:S26	R:R:V23	1.62	No	No	0	8	5
259	R:R:A184	R:R:I90	1.62	No	No	0	4	6
260	R:R:C215	R:R:K220	1.62	No	No	0	6	6
261	R:R:A230	R:R:M200	1.61	No	Yes	0	5	8
262	R:R:A267	R:R:M271	1.61	No	No	0	6	4
263	R:R:V231	R:R:V235	1.6	No	No	0	7	7
264	R:R:C79	R:R:L65	1.59	No	No	0	3	4
265	R:R:A225	R:R:L203	1.58	No	Yes	0	9	9
266	R:R:C215	R:R:N216	1.57	No	No	0	6	8
267	R:R:I50	R:R:S51	1.55	No	No	0	6	7
268	R:R:I83	R:R:S144	1.55	No	No	0	4	3
269	R:R:I2	R:R:T7	1.52	No	No	0	6	4
270	R:R:I152	R:R:T156	1.52	No	No	0	2	1
271	R:R:M200	R:R:T196	1.51	Yes	Yes	0	8	7
272	R:R:L19	R:R:V15	1.49	No	No	0	6	4
273	R:R:L270	R:R:T20	1.47	No	No	0	7	5
274	R:R:I50	R:R:I54	1.47	No	No	0	6	6
275	R:R:I142	R:R:I146	1.47	No	No	0	5	3
276	R:R:L270	R:R:T274	1.47	No	No	0	7	4
277	R:R:F126	R:R:P127	1.44	Yes	No	0	7	7
278	R:R:Q38	R:R:V39	1.43	No	No	0	6	5
279	R:R:I129	R:R:L98	1.43	No	No	0	7	6
280	R:R:Q179	R:R:V183	1.43	No	No	0	4	5
281	R:R:I197	R:R:L193	1.43	No	No	0	5	6
282	R:R:I83	R:R:N148	1.42	No	No	0	4	3
283	R:R:G33	R:R:W36	1.41	No	Yes	0	4	6
284	R:R:L131	R:R:M135	1.41	No	No	0	5	5
285	R:R:C138	R:R:F87	1.4	No	No	0	3	7
286	R:R:L16	R:R:L19	1.38	No	No	0	5	6
287	R:R:N172	R:R:Q175	1.32	No	No	0	4	1
288	R:R:S279	R:R:Y103	1.27	No	No	0	7	9
289	R:R:F9	R:R:I12	1.26	No	No	0	5	5
290	R:R:H209	R:R:H210	1.19	No	No	0	5	6
291	R:R:F178	R:R:Q179	1.17	No	No	0	4	4
292	R:R:L37	R:R:W36	1.14	No	Yes	0	5	6
293	R:R:F68	R:R:F72	1.07	No	No	0	3	3
294	R:R:F173	R:R:Y176	1.03	No	No	0	4	3
295	R:R:R40	R:R:W36	1	No	Yes	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F10	7.635	4	3	5
2	R:R:Y14	9.002	5	1	4
3	R:R:E35	4.7925	4	2	7
4	R:R:W36	3.45	4	0	6
5	R:R:V45	3.87	4	2	5
6	R:R:D46	6.585	6	2	9
7	R:R:I48	6.48	4	4	9
8	R:R:R56	6.11	4	0	9
9	R:R:Q60	4.92333	6	1	7
10	R:R:S63	5.456	5	1	5
11	R:R:N67	7.7425	4	1	3
12	R:R:W85	9.454	5	1	5
13	R:R:E86	6.365	4	1	4
14	R:R:N89	5.086	5	1	8
15	R:R:F93	6.614	5	1	6
16	R:R:T100	5.045	4	1	8
17	R:R:F102	6.2775	4	0	8
18	R:R:F126	5.376	5	4	7
19	R:R:Q151	4.216	5	6	3
20	R:R:P188	7.32	4	1	8
21	R:R:F192	7.042	5	1	8
22	R:R:T196	4.5425	4	1	7
23	R:R:M200	3.2525	4	0	8
24	R:R:L203	4.035	4	0	9
25	R:R:R222	7.47	4	8	9
26	R:R:F236	8.288	5	1	7
27	R:R:T242	4.0375	4	9	6
28	R:R:W261	10.55	5	1	4
29	R:R:E262	8.456	5	1	3
30	R:R:V265	5.1	4	0	4
31	R:R:Y266	6.12286	7	1	4
32	R:R:H272	5.446	5	0	9
33	R:R:M277	5.2025	4	0	9
34	R:R:P281	2.995	4	2	7
35	R:R:T282	5.335	4	2	8
36	R:R:L283	4.305	4	0	9
37	L:L:?1	6.3375	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F10	R:R:V260	15.0735	13.11	Yes	No	3	5	4
2	R:R:V260	R:R:W257	13.7622	2.45	No	No	0	4	3
3	R:R:F10	R:R:F9	19.1221	8.57	Yes	No	0	5	5
4	R:R:F9	R:R:I13	21.7526	11.3	No	No	0	5	7
5	R:R:E17	R:R:I13	23.0559	4.1	No	No	0	8	7
6	R:R:E17	R:R:Y266	26.9184	2.24	No	Yes	0	8	4
7	R:R:E262	R:R:Y266	30.7135	3.37	Yes	Yes	1	3	4
8	R:R:L258	R:R:W259	10.3831	10.25	No	No	0	2	3
9	R:R:Q60	R:R:Y266	12.1856	6.76	Yes	Yes	1	7	4
10	R:R:S63	R:R:Y266	28.4792	8.9	Yes	Yes	1	5	4
11	R:R:I269	R:R:Y266	61.6607	3.63	No	Yes	0	8	4
12	R:R:I269	R:R:R56	61.6448	6.26	No	Yes	0	8	9
13	R:R:H272	R:R:R56	71.3703	3.39	Yes	Yes	0	9	9
14	R:R:H272	R:R:L276	100	2.57	Yes	No	0	9	9
15	R:R:L276	R:R:L49	99.1681	4.15	No	No	0	9	8
16	R:R:I28	R:R:L49	31.8861	2.85	No	No	0	9	8
17	R:R:I28	R:R:M277	13.9643	2.92	No	Yes	0	9	9
18	R:R:M277	R:R:Q24	12.5777	12.23	Yes	No	0	9	7
19	R:R:Q24	R:R:T274	11.0328	2.83	No	No	0	7	4
20	R:R:I22	R:R:Q60	13.8217	5.49	No	Yes	0	7	7
21	R:R:I22	R:R:W61	11.0724	8.22	No	No	0	7	3
22	R:R:I28	R:R:L32	21.2178	2.85	No	No	0	9	8
23	R:R:L49	R:R:S280	66.4699	3	No	No	0	8	9
24	R:R:D46	R:R:L32	20.1957	6.79	Yes	No	0	9	8
25	R:R:D46	R:R:P281	18.0803	3.22	Yes	Yes	2	9	7
26	R:R:P281	R:R:S280	64.1445	3.56	Yes	No	0	7	9
27	R:R:D46	R:R:L42	23.3332	8.14	Yes	No	0	9	7
28	R:R:E35	R:R:L42	10.4782	2.65	Yes	No	0	7	7
29	R:R:L42	R:R:W36	10.4861	10.25	No	Yes	0	7	6
30	R:R:P281	R:R:V45	44.0082	3.53	Yes	Yes	2	7	5
31	R:R:F102	R:R:V45	42.9981	5.24	Yes	Yes	0	8	5
32	R:R:F102	R:R:I48	10.8941	2.51	Yes	Yes	0	8	9
33	R:R:N89	R:R:W85	41.8809	7.91	Yes	Yes	1	8	5
34	R:R:S55	R:R:T92	13.3899	3.2	No	No	0	8	8
35	L:L:?1	R:R:S63	26.8629	4.94	Yes	Yes	1	0	5
36	L:L:?1	R:R:E86	13.5127	5.23	Yes	Yes	1	0	4
37	L:L:?1	R:R:E262	30.5233	8.72	Yes	Yes	1	0	3
38	R:R:L81	R:R:N66	10.0899	5.49	No	No	1	2	5
39	L:L:?1	R:R:N66	24.2206	2.71	Yes	No	1	0	5
40	R:R:L65	R:R:N66	12.3084	2.75	No	No	1	4	5
41	R:R:C79	R:R:L65	10.3752	1.59	No	No	0	3	4
42	R:R:F93	R:R:N89	46.088	6.04	Yes	Yes	1	6	8
43	R:R:F236	R:R:H272	48.4412	7.92	Yes	Yes	0	7	9
44	R:R:F192	R:R:F236	34.6948	7.5	Yes	Yes	1	8	7
45	R:R:F192	R:R:T196	30.2658	3.89	Yes	Yes	1	8	7
46	R:R:F102	R:R:K106	24.8306	8.69	Yes	No	0	8	9
47	R:R:F115	R:R:I105	19.756	5.02	No	No	0	9	7
48	R:R:I105	R:R:R119	21.1385	5.01	No	No	0	7	9
49	R:R:K106	R:R:R119	23.4639	2.48	No	No	0	9	9
50	R:R:F115	R:R:H112	12.9264	3.39	No	No	0	9	7
51	R:R:H112	R:R:I114	10.0305	7.95	No	No	5	7	4
52	R:R:Q151	R:R:Q177	10.4346	3.84	Yes	No	0	3	1
53	R:R:N148	R:R:Q151	22.1527	2.64	No	Yes	6	3	3
54	R:R:I83	R:R:N148	39.9437	1.42	No	No	0	4	3
55	R:R:I83	R:R:S144	41.7304	1.55	No	No	0	4	3
56	R:R:H181	R:R:S144	41.9879	6.97	No	No	0	2	3
57	L:L:?1	R:R:H181	43.2952	4.23	Yes	No	1	0	2
58	R:R:I152	R:R:N148	16.0559	4.25	No	No	6	2	3
59	R:R:I152	R:R:T156	14.3446	1.52	No	No	0	2	1
60	R:R:Q153	R:R:T156	12.2846	2.83	No	No	0	3	1
61	R:R:Q153	R:R:Y149	10.2167	7.89	No	No	0	3	3
62	R:R:M200	R:R:T196	25.7101	1.51	Yes	Yes	0	8	7
63	R:R:L226	R:R:M200	21.4594	4.24	No	Yes	0	7	8
64	R:R:L203	R:R:L226	19.4113	2.77	Yes	No	0	9	7
65	R:R:L203	R:R:R222	16.2184	7.29	Yes	Yes	0	9	9
66	L:L:?1	R:R:W85	36.3903	21.72	Yes	Yes	1	0	5
67	R:R:F236	R:R:F93	41.4095	9.65	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S63	R:R:Y14	2.54	1	Yes	Yes	5	4	1	2
R:R:N67	R:R:Y14	10.47	1	Yes	Yes	3	4	1	2
R:R:E262	R:R:Y14	15.71	1	Yes	Yes	3	4	1	2
R:R:Y14	R:R:Y266	12.91	1	Yes	Yes	4	4	2	2
R:R:L59	R:R:W85	6.83	0	No	Yes	5	5	2	1
R:R:N67	R:R:S63	5.96	1	Yes	Yes	3	5	1	1
R:R:S63	R:R:W85	4.94	1	Yes	Yes	5	5	1	1
R:R:S63	R:R:Y266	8.9	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:S63	4.94	1	Yes	Yes	0	5	0	1
R:R:L65	R:R:N66	2.75	1	No	No	4	5	2	1
R:R:L65	R:R:L81	5.54	1	No	No	4	2	2	2
R:R:L81	R:R:N66	5.49	1	No	No	2	5	2	1
L:L:?1	R:R:N66	2.71	1	Yes	No	0	5	0	1
R:R:E262	R:R:N67	11.83	1	Yes	Yes	3	3	1	1
L:L:?1	R:R:N67	2.71	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:T82	2.91	1	Yes	No	0	1	0	1
R:R:N89	R:R:W85	7.91	1	Yes	Yes	8	5	2	1
R:R:I243	R:R:W85	5.87	0	No	Yes	3	5	2	1
L:L:?1	R:R:W85	21.72	1	Yes	Yes	0	5	0	1
R:R:E86	R:R:I90	2.73	1	Yes	No	4	6	1	2
R:R:E86	R:R:I141	2.73	1	Yes	No	4	5	1	2
R:R:E86	R:R:H181	14.77	1	Yes	No	4	2	1	1
L:L:?1	R:R:E86	5.23	1	Yes	Yes	0	4	0	1
R:R:I141	R:R:S144	3.1	0	No	No	5	3	2	2
R:R:H181	R:R:S144	6.97	1	No	No	2	3	1	2
R:R:F178	R:R:I247	2.51	0	No	No	4	4	2	1
L:L:?1	R:R:H181	4.23	1	Yes	No	0	2	0	1
R:R:I245	R:R:W261	5.87	0	No	Yes	5	4	2	1
R:R:T246	R:R:W261	10.92	1	No	Yes	4	4	1	1
L:L:?1	R:R:T246	7.76	1	Yes	No	0	4	0	1
L:L:?1	R:R:I247	5.63	1	Yes	No	0	4	0	1
R:R:F252	R:R:K254	7.44	0	No	No	2	3	2	1
R:R:F252	R:R:W261	28.06	0	No	Yes	2	4	2	1
R:R:K254	R:R:L258	4.23	0	No	No	3	2	1	2
L:L:?1	R:R:K254	6.49	1	Yes	No	0	3	0	1
R:R:E262	R:R:L258	2.65	1	Yes	No	3	2	1	2
R:R:V265	R:R:W261	4.9	0	Yes	Yes	4	4	2	1
L:L:?1	R:R:W261	3	1	Yes	Yes	0	4	0	1
R:R:E262	R:R:Y266	3.37	1	Yes	Yes	3	4	1	2
L:L:?1	R:R:E262	8.72	1	Yes	Yes	0	3	0	1
R:R:V265	R:R:Y266	5.05	0	Yes	Yes	4	4	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KPF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.48
Number of Linked Nodes	253
Number of Links	295
Number of Hubs	37
Number of Links mediated by Hubs	135
Number of Communities	9
Number of Nodes involved in Communities	57
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	52367
Length Of Smallest Path	3
Average Path Length	13.6498
Length of Longest Path	34
Minimum Path Strength	1.07
Average Path Strength	5.19886
Maximum Path Strength	18.855
Minimum Path Correlation	0.7
Average Path Correlation	0.931226
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	46.0792
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3175
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SA0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SA0
Name	Salicin
Synonyms	D-salicin
Identifier
Formula	C13 H18 O7
Molecular Weight	286.278
SMILES
PubChem	439503
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	5
Total Bonds	39
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV7
Sequence	>9KPF_nogp_Chain_R I P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R R L M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N L N Y V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S S F T H H I F L W L R W R I L R L F P W I L L G L M I T C V T I I P S A I G N Y I Q I Q L L T E N F H Q Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H C N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F D K R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K R I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K6L	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi2/β1/γ2	2.77	2025-04-02	To be published
	9K6L (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.77	2025-04-02	To be published
	9KPD	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	chim(Gs-CtGt3)/β1/γ2	2.84	2025-04-02	To be published
	9KPD (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		2.84	2025-04-02	To be published
	9KPE	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.35	2025-04-02	To be published
	9KPE (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.35	2025-04-02	To be published
	9KPF	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-	Gi1/β1/γ2	3.15	2025-04-02	To be published
	9KPF (No Gprot)	T2	Sensory	Taste2	TAS2R16	Homo sapiens	SA0	-		3.15	2025-04-02	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KPF_nogp.zip

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